Mobile diagnostic structure

Abstract

A mobile diagnostic structure according to one embodiment comprises: a housing containing a space inside; a partition module that partitions the space to include a preparation room and an analysis room; an inlet module that provides an inlet path for a raw sample from the outside to the preparation room; a transfer module that provides a transfer path from the preparation room to the analysis room for a pre-processed sample, which is a result of the raw sample being pre-processed in the preparation room; an intake unit positioned above a detection device positioned in the analysis room; and a rack installed at the position of the detection device, wherein the detection device is positioned and the rack is positioned vertically below the intake unit.

Description

Technology Field

[0001] The present invention relates to a mobile diagnostic structure. Background Technology

[0002] The 21st-century healthcare paradigm is evolving from the era of public health and disease treatment to an era of extending healthy life expectancy through disease prevention and management. In line with this global trend shifting from a focus on therapeutic medicine to preventive medicine, the demand for In Vitro Diagnostics (IVD) is increasing significantly. Global population aging and the emergence of novel viruses are also contributing factors to the growth of the IVD market. Furthermore, as treatment methods shift toward personalized care, the scope of conducting in vitro diagnostics prior to determining treatment or prescriptions is expanding.

[0003] There are various types of these in vitro diagnostics. For example, there are immune-based diagnostics based on proteins, such as antigen-antibody pairs, and nucleic acid-based diagnostics based on nucleic acids, such as DNA or RNA.

[0004] Among these, nucleic acid-based diagnostics is the fastest-growing field within in vitro diagnostics and plays a key role in the continuity of patient care. Compared to other diagnostic platforms with overlapping disease portfolios, nucleic acid-based diagnostics offers advantages such as superior test precision, the ability to miniaturize equipment, and rapid processing times.

[0005] This nucleic acid-based diagnosis is performed according to the following steps. First, nucleic acids are extracted from a sample. Next, the extracted nucleic acids are mixed with a reaction solution for nucleic acid detection. Next, whether or not a target nucleic acid is present in the mixed product is determined or detected.

[0006] Each of these steps is performed by at least one device. For example, each of the aforementioned steps may be performed by a dispensing device referred to as a liquid handling device, a nucleic acid extraction device, a setup device, or a nucleic acid detection device.

[0007] In each of the aforementioned steps, the amount of the sample handled by each device and the reagent administered to the sample may be, for example, in units of several to several hundred ml or, in some cases, in units of several to several hundred µl. Accordingly, each device is designed to perform highly sophisticated and precise movements.

[0008] Furthermore, a high level of expertise is required during the installation and operation of each device. For instance, during operation, equipment is required to prevent pathogens potentially present in specific samples from leaking out. In addition, to prevent sample contamination from external factors, the environment in which these devices are installed must also satisfy specific, strict requirements. The problem to be solved

[0009] The problem to be solved according to one embodiment includes enabling devices for performing each step of nucleic acid-based diagnosis to be easily deployed and operated anywhere in the world.

[0010] However, this project is not limited to this. means of solving the problem

[0011] A mobile diagnostic structure according to one embodiment comprises a housing having an internal space, a partitioning module that partitions the space to include a preparation room and an analysis room, an inlet module that provides an inlet path for a raw sample from the outside to the preparation room, and a transfer module that provides a transfer path from the preparation room to the analysis room for a pre-processed sample, which is a result of the raw sample being pre-processed in the preparation room.

[0012] Additionally, the compartment module may include a partition that blocks at least some of the raw sample and the preprocessed sample from being transferred between the preprocessing space and the analysis space.

[0013] In addition, the above-mentioned partition module is positioned between the above-mentioned preprocessing space and the above-mentioned analysis space and may include an optically transparent transparent portion.

[0014] In addition, the above-mentioned transfer module may include a door portion for opening and closing an opening for the transfer module formed in the above-mentioned compartment module.

[0015] Additionally, the transfer module may further include an ultraviolet irradiation unit that irradiates ultraviolet rays toward the opening for the transfer module when the opening for the transfer module is opened by the door unit, and / or an air curtain that blocks airflow through the opening for the transfer module between the pretreatment space and the analysis space.

[0016] Additionally, the delivery module may include an intermediate chamber providing a predetermined space for the preprocessing sample to be placed, a door unit on the preprocessing space side that opens and closes a connecting passage between the intermediate chamber and the preprocessing space, and a door unit on the analysis space side that opens and closes a connecting passage between the intermediate chamber and the analysis space.

[0017] In addition, the above-mentioned delivery module may further include an ultraviolet irradiation unit that irradiates ultraviolet rays toward the interior of the intermediate chamber.

[0018] In addition, the mobile diagnostic structure may further include a pressure control unit that adjusts the internal pressure of the intermediate chamber relative to the internal pressure of the pretreatment space or the internal pressure of the analysis space.

[0019] In addition, the pressure control unit adjusts the internal pressure of the intermediate chamber to be equal to the internal pressure of the pretreatment space while the connection passage of the analysis space side is blocked by the analysis space side door and the connection passage of the pretreatment space side is open by the pretreatment space side door, and can adjust the internal pressure of the intermediate chamber to be equal to the internal pressure of the analysis space while the connection passage of the pretreatment space side is blocked by the pretreatment space side door and the connection passage of the analysis space side is open by the analysis space side door.

[0020] In addition, the pressure control unit can adjust the internal pressure of the intermediate chamber to be lower than the internal pressure of the pretreatment space and the analysis space, respectively, while the connecting passage of the pretreatment space side and the connecting passage of the analysis space side are opened by the door unit of the pretreatment space side and the door unit of the analysis space side.

[0021] In addition, the mobile diagnostic structure may further include a door opening / closing control unit that controls at least one of the pre-processing space side door unit and the analysis space side door unit so that when either the pre-processing space side connecting passage and the analysis space side connecting passage is open, the other one is not opened.

[0022] In addition, the inlet module may include a door portion that opens and closes an opening for the inlet module formed in the housing.

[0023] Additionally, the inlet module may further include an ultraviolet irradiation unit that irradiates ultraviolet rays toward the opening for the inlet module when the opening for the inlet module is opened by the door unit, and / or an air curtain that blocks the airflow through the opening for the inlet module between the outside and the pre-processing space.

[0024] Additionally, the inlet module may include an intermediate chamber providing a predetermined space for the raw sample to be placed, an external door section for opening and closing a connecting passage between the outside and the intermediate chamber, and a pre-processing space side door section for opening and closing a connecting passage between the intermediate chamber and the pre-processing space.

[0025] In addition, the inlet module may further include a UV irradiation unit that irradiates ultraviolet rays toward the interior of the intermediate chamber.

[0026] In addition, the mobile diagnostic structure may further include a pressure control unit that adjusts the internal pressure of the intermediate chamber relative to the external pressure or the internal pressure of the pretreatment space.

[0027] In addition, the pressure control unit adjusts the internal pressure of the intermediate chamber to be equal to the internal pressure of the pretreatment space while the external connection passage is blocked by the external door and the pretreatment space side connection passage is open by the pretreatment space side door, and can adjust the internal pressure of the intermediate chamber to be equal to the external pressure while the external connection passage is open by the external door and the pretreatment space side connection passage is blocked by the pretreatment space side door.

[0028] Additionally, the mobile diagnostic structure may further include a first access module that provides a first access path used by a processor processing the raw sample when moving between the outside and the preprocessing space.

[0029] In addition, the first access module may include a door portion that opens and closes an opening for the first access module formed in the housing.

[0030] Additionally, the first access module may further include an ultraviolet irradiation unit that irradiates ultraviolet rays toward the opening for the first access module when the opening for the first access module is opened by the door unit, and / or an air curtain that blocks the airflow through the opening for the first access module between the outside and the pretreatment.

[0031] Additionally, the first access module may include an intermediate chamber providing a space for the processor, an external door section for opening and closing a connecting passage between the outside and the intermediate chamber, and a pre-processing space side door section for opening and closing a connecting passage between the intermediate chamber and the pre-processing space.

[0032] In addition, the first entry / exit module may further include an ultraviolet irradiation unit that irradiates ultraviolet rays toward the interior of the intermediate chamber.

[0033] In addition, the mobile diagnostic structure may further include a pressure control unit that adjusts the internal pressure of the intermediate chamber relative to the external pressure or the internal pressure of the pretreatment space.

[0034] In addition, the pressure control unit adjusts the internal pressure of the intermediate chamber to be equal to the internal pressure of the pretreatment space while the external connection passage is blocked by the external door and the pretreatment space side connection passage is open by the pretreatment space side door, and can adjust the internal pressure of the intermediate chamber to be equal to the external pressure while the external connection passage is open by the external door and the pretreatment space side connection passage is blocked by the pretreatment space side door.

[0035] In addition, the pressure control unit can adjust the internal pressure of the intermediate chamber to be lower than the external pressure and higher than the internal pressure of the pretreatment space while the external connecting passage and the pretreatment space connecting passage are opened by the external door unit and the pretreatment space door unit.

[0036] In addition, the above-mentioned inlet path and the above-mentioned first entry path may be positioned so as not to overlap each other when viewed from the top of the above-mentioned mobile diagnostic structure.

[0037] Additionally, the mobile diagnostic structure may further include a second access module that provides a second access path used by a processor to process the preprocessed sample when moving between the outside and the analysis space.

[0038] Additionally, the second access module may include an opening for the second access module formed in the housing and a door portion for opening and closing the opening for the second access module.

[0039] Additionally, the second access module may further include an ultraviolet irradiation unit that irradiates ultraviolet rays toward the opening for the second access module when the opening for the second access module is opened by the door unit, and / or an air curtain that blocks the airflow between the outside and the pretreatment through the opening for the second access module.

[0040] Additionally, the second access module may include an intermediate chamber providing a space for the processor, an external door section for opening and closing a connecting passage between the outside and the intermediate chamber, and an analysis space side door section for opening and closing a connecting passage between the intermediate chamber and the analysis space.

[0041] In addition, the second entry / exit module may further include an ultraviolet irradiation unit that irradiates ultraviolet rays toward the interior of the intermediate chamber.

[0042] In addition, the mobile diagnostic structure may further include a pressure control unit that adjusts the internal pressure of the intermediate chamber relative to the external pressure or the internal pressure of the analysis space.

[0043] In addition, the pressure control unit adjusts the internal pressure of the intermediate chamber to be equal to the internal pressure of the analysis space while the external connection passage is blocked by the external door and the analysis space side connection passage is open by the analysis space side door, and can adjust the internal pressure of the intermediate chamber to be equal to the external pressure while the analysis space side connection passage is blocked by the analysis space side door and the external connection passage is open by the external door.

[0044] In addition, the pressure control unit can adjust the internal pressure of the intermediate chamber to be higher than the external pressure and lower than the internal pressure of the analysis space while the external connecting passage and the analysis space connecting passage are opened by the external door unit and the analysis space door unit.

[0045] In addition, the above-mentioned inlet path and the above-mentioned second entry / exit path may be positioned so as not to overlap each other when viewed from the top of the above-mentioned mobile diagnostic structure.

[0046] In addition, the first access module and the second access module may be placed in the preprocessing space and the analysis space, respectively, and may be positioned so as to be in contact with each other with the partition module in between.

[0047] Additionally, a raw sample unpacking unit, a first dispensing device, and a nucleic acid extraction device are disposed in the preprocessing space, and a second dispensing device, an additional work device, and an analysis device are disposed in the analysis space, and the mobile diagnostic structure may further include a calibration notification unit that indicates that calibration is required for at least one of the raw sample unpacking unit, the first dispensing device, the nucleic acid extraction device, the second dispensing device, the additional work device, and the analysis device when a predetermined condition is satisfied.

[0048] In addition, the mobile diagnostic structure further includes a vibration detection module that detects vibration transmitted to at least one of the preprocessing space and the analysis space, and the calibration notification unit can determine whether the condition is satisfied based on at least one of the magnitude of the detected vibration and the length of time during which the vibration is detected or not detected.

[0049] Additionally, a sample collection space is further provided in the above space, wherein a sample collector stays in the sample collection space and performs a sample collection act targeting a sample provider located outside the housing, and the raw sample introduced into the preprocessing space through the inlet module may include the product of the sample collection act.

[0050] In addition, the sample collection space is provided within the pre-processing space, so that the sample collector can move between the sample collection space and the pre-processing space.

[0051] In addition, the above partition module can partition the sample collection space, the preprocessing space, and the analysis space.

[0052] Additionally, the mobile diagnostic structure further includes a glove wall positioned between the space where the sample provider stays and the sample collection space when the sample collection act is performed, wherein the glove wall may include a glove wearable on the arm of the sample collector.

[0053] Additionally, the mobile diagnostic structure further includes a sample temporary storage unit for temporarily storing at least one raw sample, including a raw sample collected from the sample provider, wherein the sample temporary storage unit may be placed in a space where the sample provider stays.

[0054] Additionally, the sample temporary storage unit may include at least one of a door for opening and closing the interior, an ultraviolet irradiation unit for irradiating ultraviolet rays toward a tube containing each of the at least one raw sample while the interior is closed by the door, and / or a disinfectant spray unit for spraying a disinfectant toward each of the tubes.

[0055] In addition, the mobile diagnostic structure may include an intake section positioned above a detection device placed in the analysis space, through which air is drawn in from the detection device.

[0056] In addition, the intake portion may be positioned vertically above the detection device.

[0057] Additionally, the air inhaled by the intake unit may include air used for cooling the detection device while the internal space of the detection device where the detection operation is performed is closed to the detection space, and may include air flowing out from the internal space while the internal space of the detection device is open to the detection space.

[0058] In addition, the intake section can inhale a relatively large amount of air while the internal space of the detection device where the detection operation is performed is open compared to the period during which it is closed to the detection space.

[0059] In addition, the mobile diagnostic structure may further include an air conditioning unit for controlling the temperature and / or humidity of the air in the detection space.

[0060] Additionally, the mobile diagnostic structure further comprises a rack installed at the placement location on which the detection device is placed, wherein the rack may include a first mounting plate on which the detection device is mounted; and a side wall surrounding at least a portion of the side surface of the detection device so as to guide the flow of air discharged or flowing out from the detection device toward the intake portion.

[0061] Additionally, the rack may further include a front wall surrounding at least a portion of the front of the detection device so that the flow of air discharged or flowing out from the detection device is guided toward the intake portion.

[0062] Additionally, the rack further includes a second mounting plate positioned vertically above the first mounting plate on which an additional detection device is mounted, and the sidewall may surround at least a portion of the side surface of the additional detection device to guide the flow of air that may flow out from the additional detection device.

[0063] Additionally, the second mounting plate includes a support portion that supports the additional detection device and a predetermined opening, and the air of the detection device mounted on the first mounting plate can be sucked into the intake portion by passing through the opening.

[0064] Meanwhile, a diagnostic vehicle according to one embodiment includes the aforementioned mobile diagnostic structure and a vehicle connected to the mobile diagnostic structure.

[0065] In addition, the above vehicle may be a vibration-free vehicle. Effects of the invention

[0066] According to one embodiment, nucleic acid-based diagnosis can be performed using a mobile diagnostic structure even in areas where equipment or environments for nucleic acid-based diagnosis are not provided. Therefore, detection of specific diseases or conditions can be performed anywhere in the world or across the country without any missed areas. This not only facilitates overall monitoring of specific diseases or conditions but also enables the meticulous establishment of disease control measures in preparation for the outbreak of infectious diseases.

[0067] In addition, the entry path through which raw samples acquired from a sample provider are introduced into the mobile diagnostic structure and the movement path to the processor handling these raw samples do not overlap when viewed from the top of the mobile diagnostic structure. By preventing the entry path and the movement path from overlapping, the possibility of cross-infection between the raw samples and the processor can be reduced.

[0068] In addition, between the pretreatment space where pretreatment of raw samples is performed and the analysis space where analysis of the pretreated samples is performed, samples are transferred by a transfer module rather than by a person. As a result, airborne or pathogen transfer between the spaces is minimized, thereby minimizing the risk of contamination or infection.

[0069] In addition, calibration alarms are generated for the devices installed inside the mobile diagnostic structure on a periodic basis or whenever an event occurs. This ensures that the condition of the nucleic acid-based diagnostic devices, which are designed to perform highly sophisticated and precise movements, is maintained at an optimal level, thereby enabling the generation of accurate nucleic acid-based diagnostic results.

[0070] In addition, the air of the detection device placed within the analysis space may contain pathogens, and these pathogens may be inhaled through the intake port placed above the detection device. Therefore, the spreading of pathogens into the analysis space can be prevented or reduced. Brief explanation of the drawing

[0071] Fig. 1 conceptually illustrates a situation in which regional hub institutions performing nucleic acid-based diagnostics are deployed in only some of the multiple regions, while no regional hub institutions are deployed in the remaining regions, and diagnostic results derived from the regional hub institutions deployed in these regions are transmitted to a central control agency. Fig. 2 conceptually illustrates a situation in which a mobile diagnostic structure according to the first embodiment is deployed in the remaining areas as illustrated in Fig. 1. Fig. 3 illustrates a perspective view of the exterior of the mobile diagnostic structure according to the first embodiment. Figs. 4 and 5 illustrate a left side view of the exterior of the mobile diagnostic structure according to the first embodiment. Figs. 6 and 7 illustrate a right side view of the exterior of the mobile diagnostic structure according to the first embodiment. Figs. 8 to 11 illustrate drawings of the internal structure of the mobile diagnostic structure. Fig. 12 illustrates a drawing of the negative pressure arrangement in the internal space of the mobile diagnostic structure. Fig. 13 illustrates an opening for an inlet module formed in the housing of the mobile diagnostic structure according to the first embodiment and A perspective view of an inlet module disposed in an opening for such an inlet module is shown as an example. Fig. 14 shows another perspective view of an inlet module disposed in an opening for such an inlet module among a movable diagnostic structure according to the first embodiment. Fig. 15 shows a conceptual diagram of the configuration of a door opening / closing control unit that controls the opening and closing of the door of the inlet module. Fig. 16 shows a perspective view of an opening for a transfer module provided in a bulkhead of a partition module among a movable diagnostic structure according to the first embodiment, and a transfer module disposed in such an opening for such a transfer module. Fig. 17 shows another perspective view of an opening for a transfer module provided in a bulkhead of a partition module among a movable diagnostic structure according to the first embodiment, and a transfer module disposed in such an opening for such a transfer module.Figure 18 shows an example of the internal pressure in the intermediate chamber of the transfer module controlled by the pressure control unit as a table. Figure 19 shows a conceptual diagram of the configuration of the door opening / closing control unit that controls the opening and closing of the door of the transfer module. FIG. 20 illustrates a conceptual diagram of additional components included in a mobile diagnostic structure according to a first embodiment. FIG. 21 conceptually illustrates a path where a sample is processed in a mobile diagnostic structure according to a first embodiment. FIG. 22 to 27 are drawings that virtually capture snapshots of possible situations occurring in a mobile diagnostic structure. FIG. 28 is a drawing illustrating the flow shown in FIG. 21 in the form of a flowchart. FIG. 29 to 31 are perspective views illustrating the internal structure of a mobile diagnostic structure according to a second embodiment. FIG. 32 is a cross-sectional view illustrating the internal structure of a mobile diagnostic structure according to a second embodiment. FIG. 33 is a perspective view of the exterior of a mobile diagnostic structure according to a third embodiment. FIG. 34 and 35 are left and right side views of the exterior of a mobile diagnostic structure according to a third embodiment. FIG. 36 is a plan view showing the internal structure of a mobile diagnostic structure. FIG. 37 conceptually illustrates a path where a sample is processed in a mobile diagnostic structure according to a third embodiment. FIG. 38 is a conceptual drawing illustrating the structure of an air conditioning system provided therein in a mobile diagnostic structure according to the fourth embodiment. FIG. 39 is a conceptual drawing illustrating the structure of an air conditioning system implemented in a manner different from that shown in FIG. 38. FIG. 40 is a conceptual drawing illustrating that the amount of air sucked in from the intake section of the air conditioning system according to the fourth embodiment varies depending on whether the opening / closing section of the analysis device is open or closed. FIG. 41 is a drawing exemplarily illustrating the external appearance of a rack and an analysis device mounted thereon in a mobile diagnostic structure according to the fourth embodiment. FIG. 42 is a perspective view of a rack according to one example in a mobile diagnostic structure according to the fourth embodiment.FIG. 43 is a perspective view of a rack according to another example in a movable diagnostic structure according to a fourth embodiment. FIG. 44 is a perspective view of a rack according to yet another example in a movable diagnostic structure according to a fourth embodiment. FIG. 45 is a perspective view of a rack according to an additional other example in a movable diagnostic structure according to a fourth embodiment. FIG. 46 is a diagram conceptually illustrating a path through which a sample is processed in a movable diagnostic structure according to a fifth embodiment. Specific details for implementing the invention

[0072] The advantages and features of the present invention and the methods for achieving them will become clear by referring to the embodiments described below in detail together with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below but can be implemented in various different forms. These embodiments are provided merely to ensure that the disclosure of the present invention is complete and to fully inform those skilled in the art of the scope of the invention, and the present invention is defined only by the scope of the claims.

[0073] In describing the embodiments of the present invention, specific descriptions of known functions or configurations will be omitted if it is determined that such detailed descriptions could unnecessarily obscure the essence of the invention. Furthermore, the terms described below are defined in consideration of their functions in the embodiments of the present invention, and these definitions may vary depending on the intentions or practices of the user or operator. Therefore, such definitions should be based on the content throughout this specification.

[0074] First, the analyte is an antigen, antibody, enzyme, or nucleic acid.

[0075] Next, a sample refers to a substance that contains or is presumed to contain the analyte discussed earlier. The subject of analysis or detection is whether the analyte is contained in such a sample.

[0076] Meanwhile, the aforementioned samples include biological samples or non-biological samples.

[0077] Among these, biological samples include at least one of viruses, bacteria, tissues, cells, blood (including whole blood, plasma and serum), lymph, bone marrow fluid, sputum, swab, aspiration, bronchial lavage fluid, bronchoalveolar lavage fluid, nasal lavage fluid, milk, urine, feces, ocular fluid, saliva, semen, brain extracts, cerebrospinal fluid (SCF), joint fluid, appendix, spleen and tonsil tissue extracts, amniotic fluid and ascites, but are not limited thereto.

[0078] In contrast, non-biological samples may include, for example, at least one of food, water, and soil.

[0079] Meanwhile, for the sample, at least one of the pretreatment, nucleic acid extraction, setup, and analysis operations may be performed sequentially.

[0080] Among these, preprocessing operations may include unpacking and deactivation operations. Unpacking refers to the process of unpacking a container when a sample is packed inside it. Additionally, deactivation refers to the process of lowering or removing the activity of an active sample.

[0081] Next, nucleic acid extraction refers to the process of extracting nucleic acids from a sample. This nucleic acid extraction process can be performed in various ways. For example, it can be carried out by any one of the following methods, or a combination of two or more: using a cell lysis solution, using heating without a cell lysis solution, using a separate enzyme (PKase), or using a separate chemical.

[0082] Next, the setup work refers to the work of preparing reagents, etc. so that nucleic acids can be detected. For example, it may include, but is not limited to, work of mixing reagents, etc. necessary for the detection of nucleic acids with a sample, or work for ICs or PCs.

[0083] Next, analysis involves detecting signals that occur dependently on the amount of nucleic acids present in a sample. Such analysis may include genetic analysis processes such as PCR, real-time PCR, or microarrays.

[0084] Here, the aforementioned signal may include an optical signal. Furthermore, various detection methods or detection operations for detecting such optical signals are known. Representative examples include TaqMan TM Probe method (U.S. Patent No. 5,210,015), molecular beacon method (Tyagi et al., Nature Biotechnology v.14 MARCH 1996), Scorpion method (Whitcombe et al., Nature Biotechnology 17:804-807 (1999)), Sunrise (or Amplifluor) method (Nazarenko et al., 2516-2521 Nucleic Acids Research, 25(12):2516-2521 (1997), and U.S. Patent No. 6,117,635), Lux method (U.S. Patent No. 7,537,886), CPT (Duck P, et al., Biotechniques, 9:142-148 (1990)), LNA method (U.S. Patent No. 6,977,295), Plexor method (Sherrill CB, et al., Journal of the American Chemical Society, 126:4550-4556 (2004)), Hybeacons TM(DJ French, et al., Molecular and Cellular Probes (2001) 13, 363-374 and U.S. Patent No. 7,348,141), dual-labeled, self-quenched probe (Dual-labeled, self-quenched probe; U.S. Patent No. 5,876,930), hybridization probe (Bernard PS, et al., Clin Chem 2000, 46, 147-148), PTOCE (PTO cleavage and extension) method (WO 2012 / 096523), PCE-SH (PTO Cleavage and Extension-Dependent Signaling Oligonucleotide Hybridization) method (WO 2013 / 115442), PCE-NH (PTO Cleavage and Extension-Dependent Non-Hybridization) method (PCT / KR2013 / 012312) and The CER method (WO 2011 / 037306) and others may be included.

[0085] Next, prior to the aforementioned detection operation, nucleic acid amplification reactions according to various methods may be performed according to the embodiments. For example, the polymerase chain reaction (PCR), the ligase chain reaction (LCR) (U.S. Patents No. 4,683,195 and 4,683,202; PCR Protocols: A Guide to Methods and Applications (Innis et al., eds, 1990)), strand displacement amplification (SDA) (Walker, et al. Nucleic Acids Res. 20(7):1691-6 (1992); Walker PCR Methods Appl 3(1):1-6 (1993)), and transcription-mediated amplification (Phyffer, et al., J. Clin. Microbiol. 34:834-841 (1996); Vuorinen, et al., J. Clin. Microbiol. 33:1856-1859 Nucleic acid sequence-based amplification (NASBA) (Compton, Nature 350(6313):91-2 (1991)), rolling circle amplification (RCA) (Lisby, Mol. Biotechnol. 12(1):75-99 (1999); Hatch et al., Genet. Anal. 15(2):35-40 (1999)), and Q-beta replicase (Lizardi et al., BiolTechnology 6:1197 (1988)) are known as such amplification methods.

[0086] In particular, nucleic acid amplification reactions involving temperature changes can be performed. In such nucleic acid amplification methods, a cycle including a denaturing step, an annealing step, and an extension (or amplification) step can be repeated dozens of times.

[0087] Meanwhile, a raw sample refers to a sample obtained from a sample provider up until just before the aforementioned pretreatment operation is performed. Such raw samples may be packed in a container such as a tube; in this case, depending on the embodiment, the tube may contain a preservative for preserving the raw sample or an inactivator for inactivating the raw sample.

[0088] Next, the preprocessed sample may refer to the sample from after the aforementioned preprocessing operation is performed until just before the aforementioned setup operation is performed, that is, the sample from the preprocessing operation and the nucleic acid extraction operation. In this case, the analysis sample may refer to the sample from after the aforementioned setup operation is performed until the aforementioned analysis operation is completed, that is, the sample from the setup operation and the analysis operation.

[0089] Next, the term "space" refers to a space where various operations on a sample, such as preparation or analysis, are performed. This space may include a sample collection space and a sample processing space, and among these, the sample processing space may include a preprocessing space, an analysis space, a first auxiliary space, and a second auxiliary space.

[0090] Among these, in the sample collection space, the act of collecting samples targeting the sample provider is performed by the sample collector.

[0091] The sample collection space is isolated by the glove wall and housing described below to prevent air from entering from the outside, specifically from the area where the sample provider stays. As a result, the likelihood of the sample collector being infected by viruses or bacteria that may be present on the sample provider is very low. Therefore, the sample collector can safely perform the sample collection activity wearing only a mask and a simple gown, without the need to wear a full-body protective suit.

[0092] Meanwhile, the sample collected from the sample provider is packed by the sample collector before being transferred to the preprocessing space. Furthermore, the packed sample is not introduced into the sample collection space; instead, as will be described later, it is temporarily stored or placed in a temporary sample storage area before being transferred to the preprocessing space via an inlet module.

[0093] Next, the aforementioned preprocessing and nucleic acid extraction operations are performed in the preprocessing space, and the setup and analysis operations are performed in the analysis space. Additionally, depending on the case, some setup operations may be performed in the preprocessing space, and the remaining setup operations (e.g., IC or PC mixing) may be performed in the analysis space.

[0094] At this time, the pretreatment space is sealed off from the outside and other spaces. Additionally, the internal pressure of the pretreatment space can be adjusted relative to the external pressure or the internal pressure of the analysis space described later. For example, the internal pressure of the pretreatment space may be negative pressure relative to the external pressure and the internal pressure of the analysis space described later while the aforementioned pretreatment operation is being performed, and may be equal to the external pressure at other times, but is not limited thereto.

[0095] In addition, the internal pressure of the analysis space can be adjusted relative to the external pressure or the internal pressure of the preprocessing space. For example, the internal pressure of the analysis space may be positive relative to the internal pressure of the preprocessing space, but is not limited to this.

[0096] Additionally, the first auxiliary space and the second auxiliary space each refer to a space other than the preprocessing space and analysis space described above. Devices that provide constant temperature and humidity functions to the preprocessing space and analysis space may be placed in these first and second auxiliary spaces, or devices that provide power or negative pressure to the devices placed in these preprocessing space or analysis space may be placed. Of course, various devices or configurations not mentioned may also be placed in these first and second auxiliary spaces.

[0097] Meanwhile, unlike what was previously described, the preprocessing sample may refer to the sample from the time the aforementioned preprocessing operation is performed until immediately before the aforementioned analysis operation is performed, that is, the sample from the preprocessing operation, nucleic acid extraction operation, and setup operation. In this case, the analysis sample may refer to the sample from the time the aforementioned analysis operation is performed until the analysis operation is completed. In this case, the aforementioned preprocessing operation, nucleic acid extraction operation, and setup operation are performed in the preprocessing space, and the analysis operation is performed in the analysis space. Additionally, depending on the case, some setup operations may be performed in the preprocessing space, and the remaining setup operations (e.g., IC or PC mixing) may be performed in the analysis space.

[0098] In contrast, the preprocessed sample may refer to a sample from the time the aforementioned preprocessing operation is performed until the completion of the said preprocessing operation, that is, a sample from the preprocessing operation. In this case, the analysis sample may refer to a sample from the time the aforementioned nucleic acid extraction operation is performed until the completion of the setup operation and the analysis operation. In this case, the aforementioned preprocessing operation is performed in the preprocessing space, and the nucleic acid extraction operation, setup operation, and analysis operation are performed in the analysis space.

[0099] Hereinafter, embodiments of the present invention will be examined with reference to the drawings. The following description is applicable not only to nucleic acid-based diagnostics but also to immune-based diagnostics and other in vitro diagnostics.

[0100] Fig. 1 conceptually illustrates a situation in which a regional hub institution (60) performing nucleic acid-based diagnosis is deployed only in some regions (1 to 5) among a plurality of regions (1 to 7), and no regional hub institution (60) is deployed in the remaining regions (6, 7), and a situation in which detection results detected by the regional hub institution (60) deployed in these regions (1 to 5) are transmitted or sent to a central control institution (40).

[0101] Here, each region (1 to 7) may be a designated area (e.g., an administrative district) belonging to the same or different countries. Additionally, a regional base institution (60) refers to a hospital or clinic equipped with equipment and an environment for nucleic acid-based diagnosis. Furthermore, a central control institution (40) refers to a hospital or national agency that collects and manages the detection results performed at each regional base institution (60).

[0102] Referring to FIG. 1, the aforementioned regional base institutions (60) are deployed only in some of the multiple partitioned regions (1 to 7), specifically in regions (1 to 5). Specifically, people or animals (hereinafter referred to as "organisms") residing in each region (1 to 5) can receive nucleic acid-based diagnostics at the regional base institutions (60) deployed in the respective regions. The results obtained by performing nucleic acid-based diagnostics at the regional base institutions (60) are transmitted to the central control agency (40) shown in FIG. 1. The transmission method may be any of the following: network, mail, personal delivery, or vehicle delivery.

[0103] In contrast, among the multiple partitioned regions (1 to 7), the remaining regions (6, 7) do not have a regional base institution (60) stationed therein. Organisms residing in these remaining regions (6, 7) cannot be provided with nucleic acid-based diagnostics in those regions. Of course, if organisms residing in these remaining regions (6, 7) move to the regions (1 to 5) where the regional base institution (60) is stationed, they can be provided with nucleic acid-based diagnostics.

[0104] However, such 'movement between regions' can lead to the spread of infection between regions. Furthermore, if the distance between regions is long, the movement itself can be a burden on the organism in terms of time and cost.

[0105] Therefore, a method is needed to enable organisms residing in the aforementioned remaining regions (6,7) to receive nucleic acid-based diagnostics in the region where they reside without moving to other regions.

[0106] FIG. 2 conceptually illustrates a situation in which a movable diagnostic structure (10) according to the first embodiment is placed in the remaining areas (6, 7) as illustrated in FIG. 1.

[0107] When comparing FIG. 2 with FIG. 1, it is the same as FIG. 1 in that local medical institutions (60) are placed in some of the multiple regions (1 to 7), specifically in regions (1 to 5). However, in FIG. 2, unlike FIG. 1, mobile diagnostic structures (10) are placed in the remaining regions (6, 7).

[0108] Here, the mobile diagnostic structure (10) refers to a structure equipped with equipment and an environment for nucleic acid-based diagnosis. This mobile diagnostic structure (10) can be connected to a vehicle, in which case it can be moved. When the mobile diagnostic structure (10) is moved and deployed to a region (6, 7) where a regional base institution (60) is not located, the organism residing in that region (6, 7) can receive nucleic acid-based diagnosis in the region where it resides without having to move to another region.

[0109] That is, according to the first embodiment, nucleic acid-based diagnosis can be performed on a mobile diagnostic structure (10) even in areas where equipment or an environment for nucleic acid-based diagnosis is not provided. Therefore, detection of a specific disease or condition can be performed anywhere in the world or across the country without any missed areas. This not only facilitates overall monitoring of a specific disease or condition, but also enables the meticulous establishment of quarantine measures in preparation for the outbreak of an infectious disease.

[0110] Below, we will first examine the appearance of this mobile diagnostic structure (10).

[0111] FIG. 3 shows a perspective view of the exterior of a movable diagnostic structure (10) according to a first embodiment, FIG. 4 and 5 show a left side view of the exterior of a movable diagnostic structure (10) according to a first embodiment, and FIG. 6 and 7 show a right side view of the exterior of a movable diagnostic structure (10) according to a first embodiment.

[0112] Referring first to FIG. 3, the mobile diagnostic structure (10) can be connected to a vehicle (20). To this end, the mobile diagnostic structure (10) and the vehicle (20) may each be provided with a configuration such as a connecting part that can be connected to each other. At this time, the vehicle (20) may be a vibration-free vehicle.

[0113] Additionally, referring to FIGS. 4 through 7 together with FIG. 3, the mobile diagnostic structure (10) includes a housing (100) having a space provided inside. This housing (100) includes a steel structural part (110). The steel structural part (110) may include not only materials such as steel but also materials with antibacterial or antiviral components. Due to these materials, pathogens that may be present inside the housing (100) cannot pass through the housing (100) to move to the outside, and vice versa.

[0114] Additionally, a solar collector panel (not shown) may be placed on the upper part of the housing (100), and in this case, a solar power generation unit (not shown) may be placed inside the housing (100). Through these solar collector panels and solar power generation units, power generated through sunlight may be provided to devices placed inside the mobile diagnostic structure (10).

[0115] Additionally, a plurality of openings are formed in the housing (100). Various configurations for a specific purpose are arranged in each of these openings.

[0116] For example, an inlet module (300) may be disposed in any one of the plurality of openings provided in the housing (100). The inlet module (300) is configured to provide an inlet path for a raw sample from outside the mobile diagnostic structure (10) to the preprocessing space. Various embodiments of such an inlet module (300) and the structure of each of these embodiments will be described in more detail later.

[0117] Additionally, a first access module (500), a second access module (600), at least one window section (151), an outdoor unit door section (161), a first auxiliary space door section (171), a second auxiliary space door section (181), and a waste extraction door section (191) may be arranged in any one of the multiple openings.

[0118] Among these, the first access module (500) is a configuration used by a processor to process raw samples when moving between the outside and the preprocessing space. The movement path through which the processor moves via this first access module (500) will be referred to as the first access path. Meanwhile, a specific embodiment of this first access module (500) will be described in more detail later.

[0119] The second access module (600) is a configuration used by a processor to move between the outside and the analysis space to process preprocessed samples. The movement path through which the processor moves via this second access module (600) will be referred to as the second access path. Meanwhile, a specific embodiment of this second access module (500) will be described in more detail later.

[0120] The window section (151) refers to a window made of optically transparent glass, and at least one may be provided as illustrated. Through this window section (151), processors within the housing (100) can check the external conditions. Additionally, this window section (151) enables light to enter the housing (100). At least one of these window sections (151) may be provided on the side of the aforementioned pre-processing space and at least one on the side of the aforementioned analysis space. At this time, the size and shape of each window section (151) may differ from one another as illustrated, but the size and shape are not limited to those illustrated in the drawing.

[0121] The door portion (161) for the outdoor unit is a door for the outdoor unit to be placed in the second auxiliary space. The door portion (161) for the outdoor unit opens when the outdoor unit is in operation. Through this opened opening, heat or moisture inside the pretreatment space (700) and analysis space (800) absorbed by the outdoor unit (920) can be released to the outside.

[0122] The door section (171) for the first unit space is configured to be used for the entry and exit of a person or a specific object between the first unit space and the outside, and the door section (181) for the second unit space is configured to be used for the entry and exit of a person or a specific object between the second unit space and the outside. Each of these door sections (171) for the first unit space and the door section (181) for the second unit space may be a hinged or sliding door, but is not limited thereto.

[0123] The waste extraction door (191) is a configuration used to extract waste generated in the pretreatment space to the outside. Through this waste extraction door (191), various types of waste, such as waste generated by unpacking raw samples, pipette tips, or swabs, can be extracted from the pretreatment space to the outside.

[0124] Let us examine the configuration of the waste extraction door section (191) in more detail. The waste extraction door section (191) includes an intermediate chamber, an outer door section, and a pre-processing space side door section. Among these, the pre-processing space side door section is arranged to open and close an opening formed in the housing (100). The intermediate chamber is formed by a partition wall that forms a side surface on the outside of the housing (100), and, for example, may be formed on the lower or side of the outer surface of the housing (100). The outer door section is arranged to open and close a connecting passage between the intermediate chamber and the outside. In addition, when the outer door section is opened, the waste contained in the intermediate chamber falls into a separate waste treatment container placed on the floor outside the mobile diagnostic structure (100) and is collected.

[0125] Here, due to these intermediate chambers and doors on both sides, even at the moment waste is withdrawn to the outside through the waste withdrawal door section (191), the magnitude of the negative pressure formed within the pretreatment space (700) may not fluctuate significantly.

[0126] Meanwhile, the configurations described above as being capable of being placed in each of the multiple openings are merely exemplary. Accordingly, at least some of the configurations described above may, in some cases, be placed in a location different from the previously described location, or in some cases, be placed in a location other than an opening, or an undescribed configuration may be placed in an opening.

[0127] Next, with reference to FIGS. 8 to 11, we will examine the interior of the movable diagnostic structure (10).

[0128] The mobile diagnostic structure (10) includes a housing (100), a partition module (200), an inlet module (300), a transfer module (400), a first entry / exit module (500), and a second entry / exit module (600). Of course, the mobile diagnostic structure (10) may include additional configurations not mentioned herein, and such additional configurations will be described later.

[0129] First, let us examine the housing (100). FIGS. 8 to 11 illustrate the steel structure (110) described above as constituting the housing (100). In addition, FIGS. 8 to 11 illustrate the window section (151), the door section for the outdoor unit (161), the door section for the first auxiliary space (171), the door section for the second auxiliary space (181), and the door section for waste extraction (191) arranged in the housing (100). For each of these housings (100) and the components (151, 161, 171, 181, 191) included therein, we will refer to the previously described details.

[0130] Next, let us look at the partition module (200). The partition module (200) is configured to partition the space inside the housing (100) into a plurality of sub-spaces. Referring to FIG. 8, the space inside the housing (100) can be partitioned by this partition module (200) into a pre-processing space (700), an analysis space (800), a first sub-space (900), and a second sub-space (1000).

[0131] These partition modules (200) include a partition section (210), a transparent section (220), and a curtain section (230), but are not limited thereto.

[0132] Among these, the partition section (210) refers to a wall. Here, the wall includes a material that prevents air or pathogens from penetrating. Therefore, between the detailed spaces partitioned by the partition section (210), air or pathogens cannot move through the partition section (210). For example, the partition section (210) is placed between the pre-processing space (700) and the first auxiliary space (900), and between the pre-processing space (700) and the analysis space (800), and between these spaces, air or pathogens cannot move through the partition section (210).

[0133] Meanwhile, at least one opening may be provided in the bulkhead (210).

[0134] A transparent section (220) may be provided in some of these openings. The transparent section (220) refers to an optically transparent configuration and may include, for example, a window made of glass. Through this transparent section (220), a person in the pre-processing space and a person in the analysis space can identify a person in the other space or the processing status in the other space.

[0135] Additionally, a transmission module (400) may be placed in some of these openings. Such a transmission module (400) will be described later.

[0136] The curtain section (230) may refer to a curtain as one of the means for partitioning the space. The analysis space (800) and the second auxiliary space (1000) are partitioned by the curtain section (230). A person in the second auxiliary space (1000) can block the gaze of a person in the analysis space (800) toward themselves by closing this curtain section (230) during a gang break.

[0137] Next, let us look at the input module (300). The input module (300) is configured to provide an input path for raw samples from the outside to the preprocessing space (700). That is, samples obtained from a sample provider from the outside can be packed and input into the preprocessing space (700) through the input module (300).

[0138] Here, the raw sample is introduced from the outside into the preprocessing space (700) through the inlet module (300), while the processor for the introduced raw sample moves between the outside and the preprocessing space (700) through the first entry / exit module (500). That is, the inlet path for the raw sample and the first movement path for the processor processing the introduced sample do not overlap when viewed from the top of the mobile diagnostic structure (10). By ensuring that the inlet path and the first movement path do not overlap, the possibility of mutual infection between the raw sample and the processor can be reduced.

[0139] Meanwhile, the inlet module (300) can be connected to the raw sample unpacking unit (710) (the raw sample unpacking unit (710) will be described later) in a sealed state with each other, which is located in the preprocessing space (700). To facilitate this sealed connection, the placement location of the inlet module (300) can be determined by considering the location where the raw sample unpacking unit (710) is placed in the preprocessing space (700). For example, the inlet module (300) can be placed so as to face each other with the raw sample unpacking unit (710) and the steel structure (110) of the housing (100) in between, but is not limited thereto.

[0140] However, the concept of the present invention is not limited to the inlet module (300) and the raw sample unpacking unit (710) being connected in a sealed state. For example, although not shown in the drawings, according to an embodiment, the inlet module (300) and the raw sample unpacking unit (710) may be placed within the preprocessing space (700) in a spaced-apart state without being connected to each other.

[0141] Meanwhile, various embodiments of the inlet module (300) and the structure of each of the various embodiments will be explained in more detail later.

[0142] The transfer module (400) may be placed in an opening formed in the partition (210) as previously described. This transfer module (400) is configured to provide a transfer path for a pre-processed sample from the pre-processing space (700) to the analysis space (800). That is, a pre-processed sample pre-processed in the pre-processing space (700) can be transferred to the analysis space (800) through the transfer module (400).

[0143] Here, the preprocessed sample is not transferred while the processor moves from the preprocessing space (700) to the analysis space (800). The preprocessed sample is transferred via the transfer module (400) without the processor moving from the preprocessing space (700) to the analysis space (800). Therefore, during the transfer process of the preprocessed sample, the possibility of contamination due to movement that could be caused by the processor's movement between spaces can be reduced.

[0144] Meanwhile, various embodiments of the delivery module (400) and the structure of each of the various embodiments will be explained in more detail later.

[0145] Next, we will examine the configurations arranged in the first unit space (900), the second unit space (1000), the preprocessing space (700), and the analysis space (800) as each detailed space.

[0146] First, a pressure control unit (910), an outdoor unit (920), and a temperature control unit (930) are arranged in the first unit space (900), but are not limited thereto.

[0147] Among these, the pressure control unit (910) is configured to generate gas pressure of various sizes, i.e., air pressure. At this time, the generated air pressure may have at least one size. For example, the pressure control unit (910) can generate air pressure of various sizes (i.e., positive pressure or negative pressure) that differs from the external air pressure by n times (where n is an integer) of 2.5 Pa. To this end, the pressure control unit (910) may include an air pressure sensing member for sensing the external air pressure or the air pressure in the space where the air pressure is provided, an air pressure generating member for generating air pressure of various sizes, and a piping member such as a duct for transmitting or providing air pressure of various sizes to different spaces. Below, we will examine the specific space where air pressure is provided by the pressure control unit (910) and the circulation of air according to the provided air pressure with reference to FIG. 12.

[0148] Referring to FIG. 12, the negative or positive pressure generated by the pressure generating member of the pressure control unit (910) is supplied to the internal space or pre-processing space (700) of the raw sample unpacking unit (710) through the piping member. Additionally, according to the embodiment, this negative or positive pressure may also be supplied to the intermediate chamber (310) of the inlet module (300) and the intermediate chamber (410) of the transfer module (400), or to the analysis space (800). If negative pressure is supplied, the air in each space is drawn toward the pressure control unit (910). Thus, the risk of air in these spaces or pathogens potentially contained therein moving to other spaces can be reduced. In this case, the piping member may extend to each space independently of one another. Thus, the possibility of cross-contamination that may occur by using the piping member jointly can be eliminated or reduced.

[0149] Meanwhile, in addition to the pressure control unit (910), air from each space can also be drawn in by an outdoor unit (920) or a constant temperature unit (930) to be described later. Likewise, the risk of air from these spaces or pathogens potentially contained therein moving to other spaces can be reduced.

[0150] Let us refer again to FIGS. 8 through 11. The pressure control unit (910) may include an antibacterial filter, for example, a HEPA filter, but is not limited thereto. For example, air sucked into the pressure control unit (910) from each space due to the provision of negative pressure passes through the antibacterial filter and is then released to the outside. Through this antibacterial filter, pathogens that may be contained in the air sucked from each space are filtered out, and thus air free of pathogens can be released to the outside. Here, if we look at the cross-section of this antibacterial filter, it may be composed of a honeycomb structure in which a plurality of hexagons are in contact. By having such a structure, the surface area where the air comes into contact with the antibacterial filter can be maximized, and thereby the antibacterial ability of the antibacterial filter can be maximized.

[0151] Additionally, the pressure control unit (910) may include an alarm member that sounds an alarm when the pressure magnitude sensed by the pressure sensing member deviates from a reference value. When the alarm is sounded by the alarm member, the pressure generating member can control the pressure generating member so that the pressure provided to each space meets the reference value.

[0152] The outdoor unit (920) is configured to control the temperature or humidity of the pretreatment space (700) and the analysis space (800). The outdoor unit (920) can perform functions similar to those included in an air conditioner / dehumidifier system. This outdoor unit (920) may be positioned adjacent to the outdoor unit door (161). When the outdoor unit (920) is in operation, the outdoor unit door (161) is opened, and heat or moisture inside the pretreatment space (700) and the analysis space (800) absorbed by the outdoor unit (920) is released to the outside through this opened opening. At this time, the outdoor unit (920) may include an antibacterial filter included in the pressure control unit (910). Through this antibacterial filter, pathogens that may be contained in the air sucked in from the pretreatment space (700) or the analysis space (800) are filtered out, and thus, air free of pathogens can be released to the outside.

[0153] The thermostat (930) is configured to control the temperature of the pretreatment space (700) and the analysis space (800).

[0154] Next, a power generation unit (1010), an emergency power supply unit (1011), and a reagent refrigerator (1012) are placed in the second unit space (1000), but are not limited thereto.

[0155] The power generation unit (1010) is a component that generates electricity. This power generation unit (1010) is provided with fuel, such as diesel fuel. By burning the provided fuel, the motor included in the power generation unit (1010) rotates, and electricity is generated by that force.

[0156] Meanwhile, the power generation unit (1010) may be positioned adjacent to the door unit (181) for the second auxiliary space. When the door unit (181) for the second auxiliary space is opened, the power generation unit (1010) can be withdrawn from the second auxiliary space (1000) to the outside through the opened opening and operated from the outside. When the power generation unit (1010) is operated from the outside rather than from the second auxiliary space (1000), the processor or various devices of the mobile diagnostic structure (10) may be less affected by noise or vibration caused by power generation. Of course, an embodiment in which the power generation unit (1010) is operated from the second auxiliary space (1000) rather than the outside is not excluded from the present invention.

[0157] Here, the door portion (181) for the second auxiliary space can be opened or closed based on a hinge as shown in FIG. 7, and unlike FIG. 7, it can be opened or closed in a sliding manner.

[0158] The emergency power supply unit (1011) is a configuration also referred to as a UPS (Uninterruptible Power Supply). This emergency power supply unit (1011) can supply power until the power generation unit (1010) operates in the event that power is not supplied due to a problem with the regular external power supply.

[0159] The reagent refrigerator (1012) is a refrigerator for storing reagents. The reagent refrigerator (1012) is connected to a power generation unit (1010), an emergency power supply unit (1011), and a constant power source from an external source (not shown in the drawing). If a problem occurs with the constant power source from the external source, the reagent refrigerator (1012) can immediately receive power from the emergency power supply unit (1011) and operate, and after the power generation unit (1010) starts operating stably, the reagent refrigerator (1012) can receive power from the power generation unit (1010) and operate. This reagent refrigerator (1012) can be operated at a temperature of approximately minus 20 degrees.

[0160] Next, a raw sample unpacking unit (710), a dispensing device (730), a nucleic acid extraction device (720), and a sample refrigerator (740) are arranged in the preprocessing space (700), but are not limited thereto.

[0161] The raw sample unpacking unit (710) is configured to perform a preprocessing operation on a raw sample that is introduced from the outside through the inflow module (300) in a packed state.

[0162] Meanwhile, during the aforementioned pretreatment process, there is a risk that pathogens that may be contained in the raw sample may be dispersed into the air. Accordingly, the raw sample unpacking unit (710) is provided with an air pressure that is lower than the external air pressure and lower than the air pressure provided to the pretreatment space (700), among the air pressures generated by the aforementioned pressure control unit (910). Through this, all air in the internal space of the raw sample unpacking unit (710) is sucked into the pressure control unit (910) and cannot be discharged into the pretreatment space (700). Therefore, the risk of pathogens that may be contained in the raw sample being dispersed from the internal space of the raw sample unpacking unit (710) to the pretreatment space (700) is reduced.

[0163] The dispensing device (730) is also referred to as a liquid handling device. This dispensing device (730) may be an automated liquid handling device operated by a computer program or a liquid handling device operated manually by a handler, and since the configuration of each of these devices is already known, a description thereof will be omitted. In addition, the nucleic acid extraction device (720) is configured to receive a sample mixed from the dispensing device (730) and extract nucleic acid from the sample.

[0164] These dispensing devices (730) and nucleic acid extraction devices (720) are placed in a pretreatment space (700). The aforementioned nucleic acid extraction operation is performed in these devices (730) and (720). Specifically, in the dispensing device (730), a mixing operation between the sample and the nucleic acid extraction drug is performed, and in the nucleic acid extraction device (720), a nucleic acid extraction operation is performed from the sample.

[0165] The sample refrigerator (740) is a refrigerator that stores the raw samples remaining after being provided to the dispensing device (730) from the raw samples unpacked and deactivated in the raw sample unpacking section (710). This sample refrigerator (740) can be operated to maintain a temperature of about minus 70 degrees.

[0166] In addition, this sample refrigerator (740) is connected to a power generation unit (1010), an emergency power supply unit (1011), and a constant power source from an external source (not shown in the drawing). If a problem occurs with the constant power source from the external source, the reagent refrigerator (1012) immediately receives power from the emergency power supply unit (1011) and operates, and after the power generation unit (1010) starts operating stably, the reagent refrigerator (1012) receives power from the power generation unit (1010) and operates.

[0167] Next, a dispensing device (810), an additional work device (820), an analysis device (830), and a computer (890) are placed in the analysis space (800), but are not limited thereto.

[0168] Among these, the dispensing device (810) has the same name as the one placed in the preprocessing space (700), but the work performed is different from that of the one placed in the preprocessing space (700).

[0169] In these dispensing devices (810) and additional work devices (820), the aforementioned setup work is performed. Specifically, in the dispensing device (810), work such as mixing between the sample received from the delivery module (400) and the reagent is performed. In addition, in the additional work device (820), work related to the IC or PC is performed.

[0170] In the analysis device (830), the aforementioned nucleic acid detection operation is performed.

[0171] The computer (890) reads the results of the work performed by the analysis device (830) from the analysis device (830). For example, the computer (890) can detect whether pathogens are present in the sample, etc., from the results of the work performed by the analysis device (830). The detected results are stored in the form of data and can be transmitted to the central control agency (40) via a network, etc., or transmitted to the central control agency (40) via a nearby regional base agency (60).

[0172] Next, let us examine each of the various embodiments of the inlet module (300).

[0173] FIG. 13 illustrates, as an example, a perspective view of an opening (120) for an inlet module formed in a housing (100) of a movable diagnostic structure according to a first embodiment and an inlet module (300) disposed in the opening (120) for the inlet module. However, FIG. 13 is merely illustrative, so the concept of the present invention is not to be interpreted as being limited to the drawing shown in FIG. 13.

[0174] Specifically, FIG. 13(a) shows a bulkhead portion (110) of a housing (100) and an opening (120) for an inlet module formed in the bulkhead portion (110). An inlet module (300) is not shown in FIG. 13(a).

[0175] Figure 13(b) illustrates a situation in which the opening (120) for the inlet module is closed by the door (302) of the inlet module (300). In this situation, the movement of air or pathogens between the outside and the pre-processing space (700) is blocked.

[0176] Figure 13 (c) illustrates a situation in which only a portion of the opening (120) for the inlet module is blocked by the door portion (302) and the rest is open. That is, the door portion (302) slides upward compared to Figure 13 (b), thereby opening a portion of the opening (120) for the inlet module.

[0177] In this situation, there is a risk that air or pathogens that may be contained therein may enter the pretreatment space (700) from the outside through the open space. To reduce this risk, the inlet module (300) in the corresponding embodiment may include an ultraviolet irradiation unit and / or an air curtain, although not shown in the drawing. The ultraviolet irradiation unit and the air curtain irradiate ultraviolet light or blow air toward the opening (120) for the inlet module, respectively, as shown by the arrow in Fig. 13 (c), when at least a part of the opening (120) for the inlet module is open to the door (302). By irradiating ultraviolet light, a sterilization effect on the air from the outside can be exerted, and the airflow between the outside and the pretreatment space (700) can be blocked by the blown air. As a result, the risk of pathogens that may be contained in the air entering the pretreatment space (700) from the outside can be reduced.

[0178] Meanwhile, FIG. 13 (d) also illustrates a situation where only a portion of the opening (120) for the inlet module is blocked by the door portion (302) and the rest is open. That is, the door portion (302) can rotate about the upper horizontal axis compared to FIG. 13 (b), thereby opening a portion of the opening (120) for the inlet module. The door portion (302) shown in FIG. 13 (d) differs from FIG. 13 (c), which slides, in that it rotates around a hinge. However, the ultraviolet irradiation portion and air curtain, etc., are the same.

[0179] FIG. 14 illustrates, as an example, another perspective view of an inlet module (300) disposed in the opening (120) for the inlet module described above among the movable diagnostic structures according to the first embodiment. However, FIG. 14 is merely illustrative, so the concept of the present invention is not to be interpreted as being limited to the drawing shown in FIG. 14.

[0180] Let us examine this in detail. Referring to FIG. 14 (a), the inlet module (300) includes an intermediate chamber (310), an outer door section (311), and a pre-processing space side door section (312), but is not limited thereto.

[0181] The intermediate chamber (310) refers to a designated space where a raw sample is placed. This intermediate chamber (310) can be implemented by a partition wall forming the side surface of the space, an external door section (311), and a pre-processing space side door section (312).

[0182] Here, the outer door section (311) is configured to open and close the connecting passage between the outside and the intermediate chamber (310), and the pre-processing space side door section (312) is configured to open and close the connecting passage between the intermediate chamber (310) and the pre-processing space (700). Each of these outer door section (311) and pre-processing space side door section (312) may include an optically transparent material. Accordingly, a processor, etc., can visually check whether a raw sample is placed inside the intermediate chamber (310).

[0183] Meanwhile, the inlet module (300) may further include an ultraviolet irradiation unit (not shown in the drawing) that irradiates ultraviolet rays toward the interior of the intermediate chamber (310). By irradiating ultraviolet rays, a sterilization effect on the air from the outside can be achieved. Through this, the risk of pathogens, etc., potentially contained in the air introduced from the outside entering the interior of the mobile diagnostic structure (10) through the inlet module (300) can be reduced.

[0184] Meanwhile, the intermediate chamber (310) of the inlet module (300) can be connected to a pressure control unit (910). The pressure control unit (910) controls the internal pressure of the intermediate chamber (310) in relation to the external pressure and the internal pressure of the pretreatment space (700). For example, the pressure control unit (910) can control the internal pressure of the intermediate chamber (310) so that it is lower than the external pressure and higher than the internal pressure of the pretreatment space (700). By doing so, the risk of pathogens, etc., that may exist in the internal space of the pretreatment space (700) leaking out through the intermediate chamber (310) can be reduced.

[0185] Meanwhile, the inlet module (300) may further include a door opening / closing control unit (340) as illustrated in FIG. 15. The door opening / closing control unit (340) is implemented to control the opening and closing of each door unit (311, 312) so that the outer door unit (311) and the pre-processing space side door unit (312) do not open simultaneously. This door opening / closing control unit (340) can be implemented electronically or mechanically. Whether the door opening / closing control unit (340) is implemented electronically or mechanically, the door opening / closing control unit (340) includes a door opening / closing detection unit (342) that detects whether each door unit (311, 312) is open or closed, and a locking unit (343) that locks the remaining door so that it does not open if one of the doors is open. When implemented electronically, the door opening / closing detection unit (342) may be a sensor that detects whether the door is open or closed, and the locking unit (343) may be a lock that receives a signal from this sensor and controls whether the door is locked. Alternatively, when implemented mechanically, the door opening / closing detection unit (342) and the locking unit (343) may be implemented as a single device. Here, since the configuration of the door opening / closing control unit (340) implemented mechanically is a known technology, a detailed description thereof will be omitted.

[0186] Next, let us examine each of the various embodiments of the delivery module (400).

[0187] FIG. 16 illustrates, as an example, a perspective view of a transfer module opening (212) provided in a partition section (210) of a partition module (200) of a movable diagnostic structure according to a first embodiment, and a transfer module (400) disposed in the transfer module opening (212). However, FIG. 16 is merely illustrative, so the concept of the present invention is not to be interpreted as being limited to the drawings shown in FIG. 16.

[0188] Specifically, FIG. 16(a) shows a partition section (210) of a partition module (200) and an opening (212) for a transfer module formed in the partition section (210). FIG. 16(a) does not show a door section (402) of a transfer module (400) to be described later.

[0189] Figure 16(b) illustrates a situation in which the opening (212) for the transfer module is closed by the door (402) of the transfer module (400). In this situation, the movement of air or pathogens between the pre-processing space (700) and the analysis space (800) is blocked.

[0190] Figure 16 (c) illustrates a situation in which only a portion of the opening (212) for the transmission module is blocked by the door portion (402) and the rest is open. That is, the door portion (402) slides upward compared to Figure 16 (b), thereby opening a portion of the opening (212) for the transmission module.

[0191] In this situation, there is a risk that air or pathogens potentially contained therein may be transferred between the pretreatment space (700) and the analysis space (800) through this open space. In particular, if the air pressure in the pretreatment space (700) is negative compared to the air pressure in the analysis space (800), there is a risk that air in the analysis space (800) or pathogens potentially contained therein may be transferred to the pretreatment space (700).

[0192] To mitigate this risk, in the corresponding embodiment, the transfer module (400) may include an ultraviolet irradiation unit and / or an air curtain, although not shown in the drawing. The ultraviolet irradiation unit and the air curtain irradiate ultraviolet light or blow air toward the opening (212) for the transfer module, as shown by the arrow in (c) of FIG. 16, respectively, when at least a portion of the opening (212) for the transfer module is open to the door (402). By irradiating ultraviolet light, a sterilization effect on the air from the outside can be exerted, and the airflow between the pretreatment space (700) and the analysis space (800) can be blocked by the blown air. Thus, the possibility of contamination due to air movement between the pretreatment space (700) and the analysis space (800) through the open space can be reduced.

[0193] Meanwhile, in FIG. 16 (d), a situation is illustrated in which only a portion of the opening (212) for the transmission module is blocked by the door portion (402) and the rest is open. That is, the door portion (402) rotates around the hinge, thereby opening a portion of the opening (212) for the transmission module. FIG. 16 (d) is different from FIG. 16 (c) in the way the door portion (402) opens, but the ultraviolet irradiation portion and air curtain, etc. are the same.

[0194] FIG. 17 illustrates, as an example, another perspective view of a transfer module opening (212) provided in a partition section (210) of a partition module (200) of a movable diagnostic structure according to the first embodiment, and a transfer module (400) disposed in the transfer module opening (212). However, FIG. 17 is merely illustrative, so the concept of the present invention is not to be interpreted as being limited to the drawing shown in FIG. 17.

[0195] Let us examine this in detail. Referring to FIG. 17 (a), the delivery module (400) includes an intermediate chamber (410), a door section (411) on the pre-processing space side, and a door section (412) on the analysis space side, but is not limited thereto.

[0196] The intermediate chamber (410) refers to a predetermined space where a pre-processed sample is placed. This intermediate chamber (410) can be implemented by a partition wall forming the side surface of the space, and a door section (411) on the pre-processed space side and a door section (412) on the analysis space side, which will be described later.

[0197] Meanwhile, although not shown in the drawing, a conveyor belt may be provided in the intermediate chamber (410). The conveyor belt may be driven by a predetermined power supply device (such as a motor). When a pre-treated sample is placed on the conveyor belt of the intermediate chamber (410), the pre-treated sample may move along the conveyor belt. The direction of movement at this time may be from the pre-treatment space (700) to the analysis space (800), but is not limited thereto.

[0198] The door section (411) on the pre-processing space side is configured to open and close the connecting passage between the pre-processing space (700) and the intermediate chamber (410), and the door section (412) on the analysis space side is configured to open and close the connecting passage between the intermediate chamber (410) and the analysis space (800). Each of these door sections on the pre-processing space side (411) and the door section on the analysis space side (412) may include an optically transparent material. Through this, the processor can visually check whether a raw sample is placed inside the intermediate chamber (410). Additionally, these door sections (411, 412) may be opened and closed automatically, although not shown in the drawing.

[0199] The delivery module (400) may further include an ultraviolet irradiation unit (not shown in the drawing) that irradiates ultraviolet rays toward the interior of the intermediate chamber (410). By irradiating ultraviolet rays, a sterilization effect on the air from the outside can be achieved, thereby reducing the risk of pathogens, etc., that may be contained in the air flowing from the pretreatment space (700) to the analysis space (800).

[0200] Meanwhile, the intermediate chamber (410) of the delivery module (400) can be connected to the pressure control unit (910). The pressure control unit (910) controls the internal pressure of the intermediate chamber (410) in relation to the internal pressure of the preprocessing space (700) and the internal pressure of the analysis space (800). FIG. 18 shows an example of the internal pressure of the intermediate chamber (410) controlled by the pressure control unit (910) as a table. Let us look at FIG. 18. First, let the internal pressure of the preprocessing space (700) be A, the internal pressure of the analysis space (800) be B, and the internal pressure of the intermediate chamber (410) be x. Additionally, let the internal pressure A of the preprocessing space (700) be negative pressure compared to the internal pressure B of the analysis space (800).

[0201] The pressure control unit (910) can set the internal pressure x of the intermediate chamber (410) lower than each of these pressures A and B when both the pretreatment space side door unit (411) and the analysis space side door unit (412) are closed (close, close). This may be a situation where a pretreatment sample is placed inside the intermediate chamber (410).

[0202] In contrast, the pressure control unit (910) can adjust the internal pressure x of the intermediate chamber (410) to be equal to the internal pressure B of the analysis space side door unit (412) when the pre-processing space side door unit (411) is closed and the analysis space side door unit (412) is open (close, open). In contrast, the pressure control unit (910) can adjust the internal pressure x of the intermediate chamber (410) to be equal to the internal pressure A of the pre-processing space side door unit (411) when the pre-processing space side door unit (411) is open and the analysis space side door unit (412) is closed (open, close).

[0203] Meanwhile, as will be explained below, the door unit (411) on the pre-processing space side and the door unit (412) on the analysis space side cannot be opened simultaneously by the door opening / closing control unit (440). Let us examine this door opening / closing control unit (440).

[0204] The transmission module (400) may further include a door opening / closing control unit (440) illustrated in FIG. 19. The door opening / closing control unit (400) is implemented to control the opening and closing of each door unit (411, 412) so that the outer door unit (411) and the pre-processing space side door unit (412) do not open simultaneously. This door opening / closing control unit (440) can be implemented electronically or mechanically. Whether the door opening / closing control unit (440) is implemented electronically or mechanically, the door opening / closing control unit (440) includes a door opening / closing detection unit (442) that detects whether each door unit (411, 412) is open or closed, and a locking unit (443) that locks the remaining door so that it does not open if one of the doors is open. When implemented electronically, the door opening / closing detection unit (442) may be a sensor that detects whether the door is open or closed, and the locking unit (443) may be a lock that receives a signal from this sensor and controls whether the door is locked. Alternatively, when implemented mechanically, the door opening / closing detection unit (442) and the locking unit (443) may be implemented as a single device. Here, since the configuration of the door opening / closing control unit (440) implemented mechanically is a known technology, a detailed description thereof will be omitted.

[0205] Meanwhile, the mobile diagnostic structure (10) may include additional components not previously mentioned. For example, the mobile diagnostic structure (10) includes a vibration detection module (1100), a calibration alarm module (1101), a vibration damping module (1102), a balance detection module (1103), and a balance control module (1104), as shown in FIG. 20, but is not limited thereto.

[0206] Among these, the vibration detection module (1100) refers to a sensor that detects vibrations by being attached to each device placed inside the mobile diagnostic structure (10) or the same. This vibration detection module (1100) can be implemented as a piezoelectric sensor. In addition, this vibration detection module (1100) may include a memory that records or stores the magnitude of the detected vibration and the duration of the detected vibration, and can calculate a numerical value based on the magnitude of the detected vibration and the duration.

[0207] The calibration alarm module (1101) is an alarm indicating that calibration is required for each device placed inside the mobile diagnostic structure (10). This calibration alarm module (1101) may be a means of emitting an alarm using sound or an image.

[0208] Specifically, the calibration alarm module (1101) can periodically generate the aforementioned alarm. The period can vary, for example, one week, one month, six months, one year, etc., and can be set or changed.

[0209] In contrast, the calibration alarm module (1101) can generate an alarm when the value calculated by the vibration detection module (1100) exceeds a predetermined threshold. For example, when the mobile diagnostic structure (10) moves from one area to another or when an earthquake occurs in the area where the mobile diagnostic structure (10) is installed, the vibration detection module (1100) can calculate a value exceeding the reference value, and the calibration alarm module (1101) can generate an alarm indicating that calibration is required based on the calculated value.

[0210] Meanwhile, the first entry module (500) and the second entry module (600) described above can each be implemented in various forms similar to the inlet module (300). For example, each entry module (500, 600) can be implemented by a door section that closes an opening provided in the housing (100), and in this case, an ultraviolet irradiation section or an air curtain, etc., may be placed at the location of such a door section. Looking at another embodiment, in the case of each entry module (500, 600), an intermediate chamber may be placed in the middle, and a door section may be placed at each of the two ends of this intermediate chamber. If a processor needs to enter the pre-processing space (700) from the outside, they can open the outer door section to enter the intermediate chamber, close the outer door section, and then open the pre-processing space side door section to enter. When exiting, the reverse order applies. In this case, the range of variation in air pressure, such as the negative pressure formed in the pre-processing space (700), due to the entry and exit of a processor through the entry / exit module (500) can be reduced compared to the case where there is no intermediate chamber. The same applies to the entry / exit module (600).

[0211] Next, let us examine the flow of a situation in which a raw sample is introduced into this mobile diagnostic structure (10), preprocessed and analyzed, and the result is derived and transmitted to a central control agency (40) via a network through a regional base institution (60) or transmitted to a central control agency (40) via a network.

[0212] FIG. 21 is a drawing illustrating the aforementioned situation together with a plan view of a mobile diagnostic structure (10), a sample collection booth (30), and a regional base institution (60), and FIG. 22 to 28 are drawings that virtually capture snapshots of situations that may actually occur in the mobile diagnostic structure (10).

[0213] Below, let us first look at Fig. 21.

[0214] ① In the sample collection booth (30), a raw sample is obtained from the sample provider (31).

[0215] ② The raw sample obtained in ① is delivered to a mobile diagnostic structure (10) in a packed state.

[0216] ③ The packed raw sample is transferred to the raw sample unpacking unit (710) via the inlet module (300). In the raw sample unpacking unit (710), unpacking and deactivation operations are performed on the sample.

[0217] ④ Some of the samples from which the work in ③ is completed are stored in a sample refrigerator (740), and the remaining samples are transferred to a dispensing device (730). In the dispensing device (730), a dispensing operation is performed on the transferred samples.

[0218] ⑤ In the nucleic acid extraction device (720), a nucleic acid extraction operation is performed from the sample from which the operation in ④ is completed. As a result, a pre-processed sample containing the extracted nucleic acid is obtained.

[0219] ⑥ The preprocessed sample obtained in ⑤ is transferred to the transfer module (400).

[0220] ⑦ The preprocessed sample is delivered to the dispensing device (810) through the delivery module (400).

[0221] ⑧ In the dispensing device (810), mixing is performed between the pretreatment sample received from the delivery module (400) and the reagent.

[0222] ⑨ In the additional work device (820), work regarding additional reagents is performed.

[0223] The sample on which the operation in ⑩ ⑨ has been performed is transferred to an analysis device (830). In the analysis device (830), an analysis operation is performed on the received sample. This analysis operation may include a nucleic acid detection operation.

[0224] 11 to 13: The result of the analysis work completed in ⑨ is transmitted to the computer (890). The computer (890) derives a nucleic acid-based diagnostic result for the raw sample. The derived nucleic acid-based diagnostic result can be transmitted to the central control agency (40) via the network (50) through the regional base institution (60) or directly to the central control agency (40) via the network (50).

[0225] Next, let's look at Figures 22 to 28.

[0226] First, FIG. 22 is a snapshot of a situation in which a processor opens the second access module (600) and enters the analysis space (800). Also, FIG. 23 is a drawing illustrating a situation in which the processor who has entered in this way is changing clothes while closing the curtain section (230) in the second auxiliary space (1000).

[0227] Here, although not illustrated in FIG. 22 and 23, there also exist situations where a processor or another processor opens the first entry module (500) and enters to enter the pre-processing space (700), and where they are changing clothes in a separate gang space.

[0228] FIG. 24 is a diagram illustrating a situation in which a raw sample obtained from a sample collection booth (30) is transferred to an inlet module (300) in a packed state.

[0229] FIG. 25 is a diagram illustrating a situation in which a raw sample delivered to the raw sample unpacking unit (710) through the inlet module (300) is unpacked and deactivated in the raw sample unpacking unit (710). This unpacking and deactivation operation can be performed when negative pressure is applied to the raw sample unpacking unit (710).

[0230] FIG. 26 is a diagram illustrating a situation in which a preprocessed sample is transferred from a preprocessing space (700) to an analysis space (800) through a transfer module (400).

[0231] FIG. 27 is a drawing illustrating the process of performing additional work on a preprocessed sample in an additional work device (820) of an analysis space (800) and the scene of performing analysis on the preprocessed sample on which additional work has been performed in an analysis device (830).

[0232] Next, FIG. 28 is a diagram illustrating the flow shown in FIG. 21 above in the form of a flowchart. However, the flowchart shown in FIG. 28 is merely illustrative, and the concept of the present invention is not to be interpreted as being limited to that shown in FIG. 28.

[0233] Referring to FIG. 28, a raw sample is obtained from a sample provider (31) in a sample collection booth (30) (S100).

[0234] The raw sample obtained in S100 is transferred in a packed state to the raw sample unpacking unit (710) of the preprocessing space (700) through the inlet module (300) of the mobile diagnostic structure (10) (S110).

[0235] In the raw sample unpacking unit (710), unpacking and deactivation operations for the raw sample are performed (S120).

[0236] Some of the raw samples from which work is completed in S120 are stored in a sample refrigerator (740), and the remaining raw samples are transferred to a dispensing device (730). In the dispensing device (730), a dispensing operation is performed on the received raw samples (S130). Here, the dispensing operation may include a mixing operation between the raw samples and a nucleic acid extraction drug.

[0237] In the nucleic acid extraction device (720), a nucleic acid extraction operation is performed from the sample from which the mixing operation in S130 is completed (S140). As a result, a pre-processed sample containing the extracted nucleic acid is obtained.

[0238] The preprocessed sample obtained in S140 is transferred to the analysis space (800) through the transfer module (400) (S150).

[0239] In the dispensing device (810), a mixing operation is performed between the sample received from the delivery module (400) and the reagent (S200).

[0240] In the additional work device (820), work regarding additional reagents (IC or PC) is performed (S210).

[0241] The sample on which the operation in S120 has been performed is transferred to an analysis device (830). In the analysis device (830), an analysis operation is performed on the received analysis sample (S220). This analysis operation may include a nucleic acid detection operation.

[0242] The result of the analysis work completed in S220 is transmitted to the computer (890). The computer (890) derives a nucleic acid-based diagnostic result for the raw sample (S230).

[0243] The derived nucleic acid-based diagnostic results can be transmitted to a central control agency (40) through a regional base institution (60) via a network (50) or directly to a central control agency (40) via a network (50) (S240).

[0244] As described above, according to the first embodiment, nucleic acid-based diagnosis can be performed using a mobile diagnostic structure even in areas where equipment or environments for nucleic acid-based diagnosis are not provided. Therefore, detection of specific diseases or conditions can be performed anywhere in the world or across the country without any missed areas. This not only facilitates overall monitoring of specific diseases or conditions but also enables the meticulous establishment of disease control measures in preparation for the outbreak of infectious diseases.

[0245] In addition, the entry path through which raw samples acquired from a sample provider are introduced into the mobile diagnostic structure and the movement path to the processor handling these raw samples do not overlap when viewed from the top of the mobile diagnostic structure. By preventing the entry path and the movement path from overlapping, the possibility of cross-infection between the raw samples and the processor can be reduced.

[0246] In addition, between the pretreatment space where pretreatment of raw samples is performed and the analysis space where analysis of the pretreated samples is performed, the raw samples are transferred by a transfer module rather than by a person. As a result, the risk of contamination or infection can be minimized by minimizing airborne or pathogen transfer between the spaces.

[0247] In addition, calibration alarms are generated for the devices installed inside the mobile diagnostic structure on a periodic basis or whenever an event occurs. This ensures that the condition of the nucleic acid-based diagnostic devices, which are designed to perform highly sophisticated and precise movements, is maintained at an optimal level, thereby enabling the generation of accurate nucleic acid-based diagnostic results.

[0248] Meanwhile, in the drawing examined above, the nucleic acid extraction device (720) is placed in the pre-processing space (720) and the dispensing device (810) and additional work device (820) are placed in the analysis space (800), but this is merely illustrative and the concept of the present invention is not limited thereto.

[0249] For example, the nucleic acid extraction device (720), the dispensing device (810), and the additional work device (820) may all be placed in the pretreatment space (700), or alternatively, these devices (720, 810, 820) may all be placed in the analysis space (800). In the former case, the pretreatment sample refers to a sample that is subject to the pretreatment operation, the nucleic acid extraction operation, and the setup operation, and the analysis sample refers to a sample that is subject to the analysis operation. On the other hand, in the latter case, the pretreatment sample refers to a sample that is subject to the pretreatment operation, and the analysis sample refers to a sample that is subject to the nucleic acid extraction operation, the setup operation, and the analysis operation.

[0250] Next, FIGS. 29 to 31 are perspective views of a movable diagnostic structure (10) according to a second embodiment of the present invention. However, FIGS. 29 to 31 are merely exemplary, and the concept of the present invention is not to be interpreted as being limited to what is shown in FIGS. 29 to 31.

[0251] Referring to FIGS. 29 to 31, a movable diagnostic structure (10) according to the second embodiment includes a housing (100), a partition module (200), an inlet module (300), a transfer module (400), a first entry / exit module (500), and a second entry / exit module (600), but is not limited thereto.

[0252] In the case of the housing (100), it is the same as in the first embodiment, so the description thereof is to be based on the part of the first embodiment.

[0253] In the case of the partition module (200), the configuration arranged between the pre-processing space (700) and the analysis space (800) in the second embodiment differs from that of the first embodiment, so let us examine this part. Specifically, a partition section (210) with an opening (212) for a transfer module is arranged between the pre-processing space (700) and the analysis space (800). However, unlike the first embodiment, an opening (211) for a transparent section is not arranged between the pre-processing space (700) and the analysis space (800). Instead, a first access module (500) and a second access module (600) are arranged at the end where the partition section (210) extends and ends.

[0254] These first entry / exit module (500) and second entry / exit module (600) are configured to be used by processors entering and exiting the preprocessing space (700) and the analysis space (800), respectively, and their purpose or use is the same as in the first embodiment. However, the placement locations of the first entry / exit module (500) and the second entry / exit module (600) differ from those in the first embodiment. In the first embodiment, the first entry / exit module (500) and the second entry / exit module (600) are placed at positions spaced apart from each other, whereas in the second embodiment, the first entry / exit module (500) and the second entry / exit module (600) are placed at positions in contact with each other.

[0255] Here, the first entry module (500) and the second entry module (600) are configured separately and are separated from each other by a partition. Therefore, even if the doors of the first entry module (500) and the second entry module (600) are opened simultaneously, there is little possibility that air or pathogens within the pre-processing space (700) will be transferred to the analysis space (800) or vice versa.

[0256] Meanwhile, in the case of the mobile diagnostic structure (10) according to this second embodiment, the remaining components are identical to those of the mobile diagnostic structure (10) according to the first embodiment, except for the aforementioned details, so the description of the first embodiment is to be used.

[0257] Meanwhile, FIG. 33 shows a perspective view of the exterior of a movable diagnostic structure (10) according to a third embodiment, and FIG. 34 and FIG. 35 show a left side view and a right side view of the exterior of a movable diagnostic structure (10) according to a third embodiment, respectively.

[0258] Referring first to FIG. 33, the mobile diagnostic structure (10) can be connected to a vehicle (20). To this end, the mobile diagnostic structure (10) and the vehicle (20) may each be provided with a configuration such as a connecting part that can be connected to each other. At this time, the vehicle (20) may be a vibration-free vehicle.

[0259] Additionally, referring to FIGS. 34 and 35 together with FIG. 33, the mobile diagnostic structure (10) includes a housing (100) having a space provided inside. This housing (100) includes a steel structure (110). The steel structure (110) may include not only materials such as steel but also materials with antibacterial or antiviral components. Due to these materials, pathogens that may be present inside the housing (100) cannot pass through the housing (100) to move to the outside, and vice versa.

[0260] Additionally, a solar collector panel (not shown) may be placed on the upper part of the housing (100), and in this case, a solar power generation unit (not shown) may be placed inside the housing (100). Through these solar collector panels and solar power generation units, power generated through sunlight may be provided to devices placed inside the mobile diagnostic structure (10).

[0261] Additionally, the housing (100) is provided with a plurality of openings. Various configurations for a specific purpose are arranged in each of these openings.

[0262] For example, a first delivery module (300) may be disposed in any one of the plurality of openings provided in the housing (100). The first delivery module (300) is configured to provide an inflow path (which may be referred to as the 'first delivery path') through which a raw sample is introduced from outside the mobile diagnostic structure (10) into the preparation space. Various embodiments of such first delivery module (300) and the structure having each of the various embodiments will be made by reference to the inflow module (300) according to the first embodiment.

[0263] Additionally, a first access module (111), at least one window section (151), an outdoor unit door section (161), a first auxiliary space door section (171), a second auxiliary space door section (181), and a waste extraction door section (191) may be provided in any one of the multiple openings.

[0264] Among these, the first access module (111) is configured to be used when a setup agent to process raw samples moves between the outside and the preparation space, or when an analysis agent moves between the outside and the analysis space. Hereinafter, the movement path of the setup agent moving between the outside and the preparation space through this first access module (111) will be referred to as the first access path, and the movement path of the analysis agent moving between the outside and the analysis space will be referred to as the second access path. Meanwhile, a specific embodiment of this first access module (111) will be described in more detail later.

[0265] The window section (151) refers to a window made of optically transparent glass, and at least one may be provided as illustrated. Through this window section (151), the processors inside the housing (100) can check the external conditions. In addition, this window section (151) enables light to enter the housing (100).

[0266] The door portion (161) for the outdoor unit is a door for the outdoor unit to be placed in the second auxiliary space. The door portion (161) for the outdoor unit opens when the outdoor unit is in operation. Through this opened opening, heat or moisture inside the preparation space (700) and analysis space (800) absorbed by the outdoor unit (920) can be released to the outside.

[0267] The door section (171) for the first unit space is a configuration used for the entry and exit of people or specific objects between the first unit space and the outside. This door section (171) for the first unit space may be a hinged or sliding door, but is not limited thereto.

[0268] The waste extraction door (191) is a configuration used to extract waste generated in the preparation space to the outside. Through this waste extraction door (191), various types of waste, such as waste generated by unpacking raw samples, pipette tips, or swabs, can be extracted from the preparation space to the outside.

[0269] Below, let us examine the configuration of the waste extraction door section (191) in more detail. The waste extraction door section (191) includes an intermediate chamber, an outer door section, and a preparation space side door section. The intermediate chamber is a space formed across the housing (100). One side of the intermediate chamber can be opened and closed by the preparation space side door section, and the other side can be opened and closed by the outer door section. When waste is generated in the preparation space, such waste is fed into the intermediate chamber when the preparation space side door section is opened, and then, when the outer door section is opened, it falls into a separate waste disposal container placed on the floor outside the mobile diagnostic structure (100) and is collected.

[0270] Here, due to these intermediate chambers and doors on both sides, the magnitude of the negative pressure formed within the preparation space may not fluctuate significantly even at the moment when waste is withdrawn to the outside through the waste withdrawal door section (191).

[0271] Meanwhile, the configurations described above as being capable of being placed in each of the multiple openings are merely exemplary. Accordingly, at least some of the configurations described above may, in some cases, be placed in a location different from the previously described location, or in some cases, be placed in a location other than an opening, or an undescribed configuration may be placed in an opening.

[0272] Next, with reference to FIG. 36, we will examine the interior of the movable diagnostic structure (10).

[0273] The mobile diagnostic structure (10) includes a housing (100), a partition module (200), a first transfer module (300), a second transfer module (400), and a first access module (111). Of course, the mobile diagnostic structure (10) may include additional configurations not mentioned herein, and such additional configurations will be described later.

[0274] First, let us examine the housing (100). FIG. 36 illustrates the steel structure (110) described earlier as constituting the housing (100). In addition, FIG. 36 illustrates the window section (151), the door section (161) for the outdoor unit, the door section (171) for the first auxiliary space, and the door section (191) for waste extraction that are arranged in the housing (100). For each of these housings (100) and the components (151, 161, 171, 191) included therein, we will refer to the descriptions previously made in the first embodiment.

[0275] Next, let us look at the partition module (200). The partition module (200) is configured to partition the space inside the housing (100) into a plurality of sub-spaces. Referring to FIG. 36, the space inside the housing (100) can be partitioned by this partition module (200) into a preparation space (700), an analysis space (800), a first sub-space (900), and a second sub-space (1000).

[0276] These partition modules (200) include a partition section (210), a transparent section (220), and a curtain section (230), but are not limited thereto.

[0277] Among these, the partition section (210) refers to a wall. Here, the wall includes a material that cannot penetrate air or pathogens. Therefore, between the detailed spaces partitioned by the partition section (210), air or pathogens cannot move through the partition section (210). For example, the partition section (210) is placed between the preparation space (700) and the first auxiliary space (900), and between the preparation space (700) and the analysis space (800), and between these spaces, air or pathogens cannot move through the partition section (210).

[0278] Meanwhile, at least one opening may be provided in the bulkhead (210).

[0279] A transparent section (220) may be provided in some of these openings. The transparent section (220) refers to an optically transparent configuration and may include, for example, a window made of glass. Through this transparent section (220), a person in the preparation space (700) and a person in the analysis space (800) can identify a person in the other space or the processing status in the other space.

[0280] Additionally, a first transmission module (300) and a second transmission module (400) may be disposed in some of these openings. For these configurations, the description of the inlet module (300) and the transmission module (400) described in the first embodiment will be used by reference.

[0281] The curtain section (230) may refer to a curtain as one of the means for partitioning the space. The analysis space (800) and the second auxiliary space (1000) are partitioned by the curtain section (230). A person in the second auxiliary space (1000) can block the gaze of a person in the analysis space (800) toward themselves by closing this curtain section (230) during a gang break.

[0282] Next, let us look at the first delivery module (300). The first delivery module (300) is configured to provide an inflow path (first delivery path) for raw samples from the outside to the preparation space (700). That is, samples obtained from a sample provider from the outside can be packed (stored in a sample temporary storage unit to be described later) and then introduced into the preparation space (700) through the first delivery module (300).

[0283] Here, the raw sample is introduced from the outside into the preparation space (700) through the first delivery module (300), while the setup personnel processing the sample introduced in this way move between the outside and the preparation space (700) through the first entry / exit module (111). That is, the first delivery path for the raw sample and the first movement path for the setup personnel processing the sample introduced in this way do not overlap when viewed from the top of the mobile diagnostic structure (10). By ensuring that the first delivery path and the first movement path do not overlap, the possibility of cross-infection between the raw sample and the processor can be reduced.

[0284] Meanwhile, the first delivery module (300) can be connected to the raw sample unpacking unit (710) (the raw sample unpacking unit (710) will be described later) in a sealed state with each other, which is located in the preparation space (700). To facilitate this sealed connection, the placement position of the first delivery module (300) can be determined by considering the position where the raw sample unpacking unit (710) is placed in the preparation space (700). For example, the first delivery module (300) can be placed so as to face each other with the raw sample unpacking unit (710) and the steel structure (110) of the housing (100) in between, but is not limited thereto.

[0285] However, the concept of the present invention is not limited to the first delivery module (300) and the raw sample unpacking unit (710) being connected in a sealed state. For example, according to an embodiment, the first delivery module (300) and the raw sample unpacking unit (710) may be placed in the preparation space (700) in a spaced-apart state without being connected to each other.

[0286] The second transfer module (400) may be placed in an opening provided in the partition (210) as previously described. This second transfer module (400) is configured to provide a second transfer path for a pre-processed sample from the preparation space (700) to the analysis space (800). That is, a pre-processed sample processed in the preparation space (700) can be transferred to the analysis space (800) through the second transfer module (400).

[0287] Here, the pre-processed sample is not transferred by a person moving from the preparation space (700) to the analysis space (800). The pre-processed sample is transferred through the second transfer module (400). Therefore, during the transfer process of the pre-processed sample, the possibility of contamination due to movement that could be caused by a person moving between spaces can be reduced.

[0288] Meanwhile, regarding the various embodiments of the second transmission module (400) and the structure of each of the various embodiments, the one described in the first embodiment for the transmission module (400) is to be adopted.

[0289] Next, let us examine the configurations arranged in each detailed space, namely the first sub-space (900), the second sub-space (1000), the sample collection space (501), the preparation space (700), and the analysis space (800). However, except for the sample collection space (501), they are identical to those described in the first embodiment, so we will refer to the descriptions for these and examine only the configurations arranged in the sample collection space (600).

[0290] A glove wall (510) is positioned between the sample collector and the sample provider staying in the sample collection space (501). The glove wall (510) may include a transparent section (511), an opening (512), and a glove section (513). The transparent section (511) is a partition made of a transparent material. By this transparent section (511) and the housing (100), the sample collection space (501) is isolated from the outside, particularly from the space where the sample provider stays. The opening (512) refers to an opening formed in the transparent section (511). Through this opening (512), both arms of the sample collector can reach toward the sample provider and reach the space where the sample provider stays. The glove section (513) refers to a glove connected thereto that blocks the opening (512). The sample collector can collect a sample by wearing the glove portion (513) on both arms and extending both arms toward the sample provider through the opening (512).

[0291] FIG. 37 conceptually illustrates a path through which a sample is processed in a mobile diagnostic structure according to a third embodiment. However, FIG. 37 is merely illustrative, and therefore the concept of the present invention is not to be interpreted as being limited to that depicted in FIG. 37.

[0292] Referring to Fig. 37,

[0293] ① In the sample collection space (501), a raw sample is collected or obtained from a sample provider.

[0294] ② The raw sample obtained in ① is placed in a sample temporary storage unit (520) in a packed state.

[0295] ③ When a certain number of raw samples are collected in the sample temporary storage unit (520), these raw samples are transferred to the raw sample unpacking unit (710) through the first transfer module (300). In the raw sample unpacking unit (710), unpacking and deactivation operations are performed on the samples.

[0296] ④ Some of the samples from which the work in ③ is completed are stored in a sample refrigerator (740), and the remaining samples are transferred to a dispensing device (730). In the dispensing device (730), a dispensing operation is performed on the transferred samples.

[0297] ⑤ In the nucleic acid extraction device (720), a nucleic acid extraction operation is performed from the sample from which the operation in ④ is completed. As a result, a pre-processed sample containing the extracted nucleic acid is obtained.

[0298] ⑥ The preprocessed sample obtained in ⑤ is transferred to the second transfer module (400).

[0299] ⑦ The pre-processed sample is delivered to the dispensing device (810) through the second delivery module (400).

[0300] ⑧ In the dispensing device (810), a mixing operation is performed between the pretreatment sample received from the second delivery module (400) and the reagent.

[0301] ⑨ In the additional work device (820), work regarding additional reagents is performed.

[0302] The sample from which the work in ⑩ ⑨ has been performed is transferred to an analysis device (830). In the analysis device (830), an analysis of the received sample is performed.

[0303] 11 to 12: The results of the analysis work completed in ⑨ are transmitted to the computer (890). The computer (890) derives a nucleic acid-based diagnostic result for the raw sample. The derived nucleic acid-based diagnostic result can be transmitted to the central control agency (40) via the network (50) through the regional base institution (60) or directly to the central control agency (40) via the network (50).

[0304] Meanwhile, the third embodiment described in FIGS. 33 to 36 described above can be implemented as follows. For example, a mobile diagnostic structure according to this third embodiment may include a housing having a space provided inside, and the housing may be implemented to include a sample collection space and a sample processing space included within the space. In this case, a sample collector stays in the sample collection space and performs a sample collection activity targeting a sample provider located outside the housing, and in the sample processing space, a preprocessing operation on a raw sample which is the product of the sample collection activity and an analysis operation on a preprocessed sample which is the product of the preprocessing operation are performed.

[0305] Meanwhile, the mobile diagnostic structure according to the various embodiments described above is equipped with an air conditioning system, and we will examine several embodiments of such air conditioning systems below. Here, it is assumed that each of these air conditioning systems is applicable not only to the fourth embodiment but also to each of the various embodiments examined above.

[0306] First, FIG. 38 is a conceptual plan view illustrating the structure of an air conditioning system provided therein in a movable diagnostic structure according to a fourth embodiment. However, FIG. 38 is merely illustrative, so the concept of the present invention is not to be interpreted as being limited to that depicted in FIG. 38.

[0307] Referring to the plan view illustrated in FIG. 38, the aforementioned pressure control unit (910) positioned in the first auxiliary space (900) provides negative pressure generated by the aforementioned pressure generating member to the pre-processing space (700) through a piping member. At this time, a negative pressure providing hood (911) may be positioned at the end of the piping member opposite to the end connected to the pressure control unit (910), that is, the end connected to the pre-processing space (700). Additionally, this negative pressure providing hood (911) may be positioned on the ceiling of the pre-processing space (700).

[0308] Next, the aforementioned outdoor unit (920) or thermostat (930) placed in the first auxiliary space (900) performs an air conditioning function for the air in the pretreatment space (700) or analysis space (800) through a piping member.

[0309] Specifically, two piping members are provided that are connected to the outdoor unit (920) and the constant temperature unit (930), respectively. Each piping member is connected to the pretreatment space (700) and the analysis space (800). Furthermore, these piping members are provided independently of each other. Accordingly, air passing through one piping member does not mix with air passing through another piping member, at least through the piping member.

[0310] And one of these piping members is connected to a hood (921) placed in the pretreatment space (700) and a hood (922) placed in the analysis space (800). And another piping member is connected to a hood (924) placed in the pretreatment space (700) and a hood (925) placed in the analysis space (800). At this time, according to the embodiment, each hood (921, 922, 924, 925) may be placed on the ceiling of each space (700, 800), but is not limited thereto. For example, according to the embodiment, each hood (921, 922, 924, 925) may be placed on the side or floor of each space (700, 800).

[0311] At this time, air from the pretreatment space (700) and the analysis space (800) is sucked in through one of the two aforementioned pipe members. In FIG. 38, the pipe member connected to the hood (921, 922) corresponds to this. In this respect, the hood (921, 922) may each be referred to as an 'intake part'.

[0312] In contrast, air is supplied to the pretreatment space (700) and the analysis space (800) through the other of the two aforementioned pipe members. In FIG. 38, this corresponds to the pipe member connected to the hood (924, 925). In this respect, the hood (924, 925) may each be referred to as an 'air supply unit'.

[0313] Here, among the aforementioned intake parts (921, 922), the intake part (922) located in the analysis space (800) may be placed on the ceiling above the analysis device (830). Additionally, according to an embodiment, this intake part (922) may be placed on the vertical upper part of the analysis device (830).

[0314] If the intake section (922) is positioned at the top of the analysis device (830), air from the analysis device (830) can be drawn into the intake section (922) more smoothly.

[0315] More specifically, the intake section (922) may receive air used for cooling the analysis device (830) discharged from the analysis device (830) or air flowing out from the internal space of the analysis device (830).

[0316] Here, the air used for cooling the analysis device (830) refers to the fact that heat is generated while the analysis device (830) performs an analysis operation, and a fan is provided in the analysis device (830) to cool this heat. By operating this fan, the air used for cooling can be discharged from the analysis device (830).

[0317] Next, let us look at the air flowing out of the internal space of the analysis device (830). In the internal space of the analysis device (830), a detection operation for the target analyte is performed. In this case, the internal space may contain pathogens or bacteria. When this detection operation is completed, the internal space of the analysis device (830) is opened by an opening / closing part that opens and closes the internal space of the analysis device (830) to the analysis space (800), and at this time, pathogens or bacteria that may be contained in the internal space may be mixed with the air and flow out into the analysis space (800).

[0318] Here, according to the embodiment, the amount of air sucked into the intake section (922) can be adjusted depending on the situation. For example, the amount of air sucked in may be relatively greater when the opening / closing section of the analysis device (830) described above is open than when it is closed, as conceptually illustrated in FIG. 39. Through this, the possibility of the aforementioned pathogens or bacteria spreading into the air of the analysis space (800) can be reduced. Meanwhile, for this purpose, the aforementioned outdoor unit (920) or thermostat (930) may be equipped with a means (a sensor or a processor that knows the timing in advance) for detecting whether the opening / closing section of the analysis device (830) is open or closed.

[0319] FIG. 40 is a conceptual plan view illustrating the structure of an air conditioning system implemented in a manner different from that shown in FIG. 38. However, FIG. 40 is merely illustrative, and the concept of the present invention is not to be interpreted as being limited to that shown in FIG. 40.

[0320] Referring to FIG. 40, the analysis space (800) is identical to FIG. 38 except that an additional intake section (923) is disposed therein. For example, the intake section (921) is a means for inhaling air from the pretreatment space (700), and the intake section (922) is a means for inhaling air from the analysis space (800). Additionally, the intake section (922) may be disposed above the analysis device (8300) of the analysis space (800), preferably vertically above it. Accordingly, the description of the same parts will be based on the previously described parts, and only the additional intake section (923) will be described.

[0321] In the case of the added intake port (923), it is placed in the analysis space (800) and used for air conditioning of the air in the analysis space (800). Specifically, air around the analysis device (830) placed below it is mainly drawn into the intake port (922), whereas air within the analysis space (800), including air around the analysis device (830), is drawn into the added intake port (923). That is, in the embodiment illustrated in FIG. 40, an intake port (923) for air conditioning of the air inside the analysis space (800) and an intake port (922) for air around the analysis device (830) are placed in the analysis space (800).

[0322] Meanwhile, as previously described, the intake port (922) is a means for the surrounding air of the analysis device (830) to be drawn in. The main effect or purpose of this intake port (822) is to allow air flowing out or being discharged from the analysis device (830) to be drawn in. The reason for the intake is to reduce or prevent air containing the heat of the analysis device (830) or pathogens from the analysis device (830) from spreading into the analysis space (800), as previously described.

[0323] Accordingly, in one embodiment, in addition to the aforementioned intake port (922), a configuration is provided to reduce or prevent air containing the aforementioned heat or air containing pathogens from spreading into the analysis space (800). Let us look at FIGS. 41 to 45 regarding this configuration.

[0324] FIG. 41 is a modified drawing of FIG. 27, wherein a rack on which an analysis device (830) of reference number 830 is placed is assigned reference number 831. At least one analysis device (830) may be placed on this rack (831). Additionally, this rack (831) is placed in an analysis space (800). According to an embodiment, although not shown in the drawing, this rack (831) may be placed below the intake port (922), preferably vertically below the intake port (922).

[0325] Below, let us examine the structure of this rack (831) in more detail.

[0326] FIG. 42 is a perspective view of a rack (831) according to one example in a movable diagnostic structure according to a fourth embodiment. However, FIG. 42 is merely illustrative, so the concept of the present invention is not to be interpreted as being limited to that shown in FIG. 42.

[0327] Referring to FIG. 42, the rack (831) includes a first mounting plate (8311) and side walls (8312, 8313), but is not limited thereto. For example, the rack (831) may include two horizontal bars connecting the two side walls (8312, 8313), as shown in FIG. 42. Additionally, the top of the rack (831) is open, as shown in FIG. 42.

[0328] An analysis device (830) is mounted on the first mounting plate (8311). In FIG. 42, the mounting positions are shown by dotted lines (83111, 83112). As shown in FIG. 42, two analysis devices (830) may be mounted on the first mounting plate (8311). Of course, depending on the embodiment, one or three or more analysis devices (830) may be mounted.

[0329] The side walls (8312, 8313) are configured to surround at least a portion of the side surface of the analysis device (830), provided that the analysis device (830) is mounted on the first mounting plate (8311). Referring to FIG. 42, the side surfaces of the analysis device (830), excluding the front and rear, are surrounded by these side walls (8312, 8313). Through these side walls (8312, 8313), the air of the analysis device (830) cannot pass through at least the side walls (8312, 8313) and can be guided toward the intake port (922) by these side walls (8312, 8313). Therefore, even if the air contains pathogens, etc., or if the air retains heat due to the operation of the analysis device (830), contamination, infection, or burns caused therefrom can be reduced or prevented.

[0330] FIG. 43 is a perspective view of a rack (831) according to another example in a movable diagnostic structure according to a first embodiment. Unlike FIG. 42, a front wall (8314, 8315) is positioned on the front of this rack (831). This front wall (8314, 8315) is connected to a side wall (8312, 8313) via a hinge so that it can be opened or closed. When opened, the user can use the analysis device (830). And when closed, the air of the analysis device (830) can be guided toward the intake port (922) by the side wall (8312, 8313) and this front wall (8314, 8315). Thus, even if the air contains pathogens, etc., or if the air retains heat due to the operation of the analysis device (830), contamination, infection, or burns caused therefrom can be reduced or prevented.

[0331] FIG. 44 is a perspective view of a rack (831) according to another example in a movable diagnostic structure according to a first embodiment. This rack (831) differs in that it includes a second mounting plate (8316) in the rack (830) shown in FIG. 42. At least one detection device (830) is mounted on this second mounting plate (8316) just as on the first mounting plate (8311), and the mounting positions are indicated by reference numbers 83161 and 83162.

[0332] In addition, the sidewalls (8312, 8313) are connected to the second mounting plate (8316) so that both side surfaces, excluding the front and rear of the other analysis device (830) mounted on the second mounting plate (8316), can be surrounded. Likewise, through these sidewalls (8312, 8313), the air of the other analysis device (830) cannot pass through at least the sidewalls (8312, 8313) and can be guided toward the intake port (922) by these sidewalls (8312, 8313). Therefore, even if the air contains pathogens, etc., or if the air retains heat due to the operation of the other analysis device (830), contamination, infection, or burns caused therefrom can be reduced or prevented.

[0333] Meanwhile, FIG. 45 is a perspective view of a rack (831) according to an additional example in a movable diagnostic structure according to a first embodiment. The rack (831) shown in FIG. 45 differs from the rack (831) shown in FIG. 44 in that an opening (83163, 83164) is provided in the second mounting plate (8316). Two such openings (83163, 83164) may be provided, and depending on the embodiment, one or three or more may be provided.

[0334] These openings (83163, 83164) provide a path for air to pass through which air is discharged or flows out from a detection device (830) mounted on a first mounting plate (8311). Specifically, air discharged or flows out from a detection device (830) mounted on a first mounting plate (8311) is guided upward through the openings (83163, 83164) and can finally be sucked into an intake section (922).

[0335] FIG. 46 is a conceptual diagram illustrating the path along which a sample is processed in a mobile diagnostic structure according to a fifth embodiment. Referring to FIG. 46, a first transfer module (300) may be positioned to provide transfer of a raw sample from a sample collection space (501) to a preparation space (700). More specifically,

[0336] ① A raw sample is collected or obtained from a sample provider outside the housing by a sample collector staying in the sample collection space (501).

[0337] ② The raw sample obtained in ① is transferred to the sample collection space (501) through an opening (not shown in FIG. 47).

[0338] ③ When a certain number of raw samples are collected in the sample collection space (501), these raw samples are transferred to the raw sample unpacking unit (710) in the preparation space (700) via the first transfer module (300). That is, the first transfer module (300) provides an inflow path from the sample collection space (501) to the preparation space (700). In the raw sample unpacking unit (710), unpacking and deactivation operations for the samples are performed.

[0339] ④ From step ④ onwards, it is the same as described in FIG. 37. Therefore, the aforementioned description of the steps described in FIG. 37 can be applied to steps ④ through ⑫ described in FIG. 46.

[0340] As described above, according to various embodiments, air leaking or discharged from a detection device placed within an analysis space (detection space) may contain pathogens, etc., and such pathogens, etc. can be inhaled through an intake port placed above the detection device. Therefore, the spreading of pathogens, etc. into the analysis space can be prevented or reduced.

[0341] The present application claims priority to Korean Patent Applications No. 10-2020-0184169, No. 10-2021-0022267, and No. 10-2021-0138198, filed with the Korean Intellectual Property Office on December 28, 2020, February 19, 2021, and October 18, 2021, respectively. The disclosures thereof are incorporated herein by reference in their entirety.

Claims

Claim 1 A housing containing a space inside; a partition module that partitions the space to include a preprocessing space and an analysis space; an inlet module that provides an inlet path for a raw sample from the outside to the preprocessing space; a transfer module that provides a transfer path from the preprocessing space to the analysis space for a preprocessed sample, which is the result of the raw sample being preprocessed in the preprocessing space; an intake unit positioned above a detection device positioned in the analysis space; and a rack installed at the position of the detection device and positioned vertically below the intake unit, wherein air discharged from the detection device is sucked into the intake unit, and the rack comprises a first mounting plate on which the detection device is mounted. and includes a sidewall surrounding at least a portion of the side surface of the detection device so that the flow of air exiting from the detection device is guided toward the intake portion, and the transfer module includes an intermediate chamber providing a predetermined space for the pretreatment sample to be placed, a pretreatment space side door portion for opening and closing a connecting passage between the intermediate chamber and the pretreatment space, an analysis space side door portion for opening and closing a connecting passage between the intermediate chamber and the analysis space, a pressure control portion for controlling the internal pressure of the intermediate chamber, and a pressure control portion for controlling the pressure control portion, wherein the pressure control portion adjusts the internal pressure of the intermediate chamber to be equal to the internal pressure of the pretreatment space while the connecting passage of the analysis space side is blocked by the analysis space side door portion and the connecting passage of the pretreatment space side is open by the pretreatment space side door portion, and while the connecting passage of the pretreatment space side is blocked by the pretreatment space side door portion and the connecting passage of the analysis space side is open by the analysis space side door portion, the internal pressure of the intermediate chamber is the A mobile diagnostic structure that adjusts to be equal to the internal pressure of the analysis space. Claim 2 A movable diagnostic structure according to claim 1, wherein the compartment module includes a partition that blocks the transfer of the pretreatment sample between the pretreatment space and the analysis space, except that the pretreatment sample passes through the transfer module, and the pretreatment sample is transferred from the pretreatment space to the analysis space through the transfer section. Claim 3 In claim 1, the partition module is disposed between the preprocessing space and the analysis space and is a movable diagnostic structure comprising an optically transparent transparent part. Claim 4 A movable diagnostic structure according to claim 1, wherein the transfer module includes a door portion for opening and closing an opening for a transfer module formed in the partition module. Claim 5 A movable diagnostic structure according to claim 4, wherein the transfer module further comprises an ultraviolet irradiation unit that irradiates ultraviolet rays toward the opening for the transfer module when the opening for the transfer module is opened by the door unit, and / or an air curtain that blocks airflow through the opening for the transfer module between the preprocessing space and the analysis space. Claim 6 delete Claim 7 A movable diagnostic structure according to claim 1, wherein the delivery module further comprises an ultraviolet irradiation unit that irradiates ultraviolet rays toward the interior of the intermediate chamber. Claim 8 delete Claim 9 delete Claim 10 A movable diagnostic structure according to claim 1, wherein the pressure control unit controls the internal pressure of the intermediate chamber to be lower than the internal pressure of the pretreatment space and the analysis space, respectively, while both the connecting passage of the pretreatment space side and the connecting passage of the analysis space side are closed by the pretreatment space side door unit and the analysis space side door unit. Claim 11 A movable diagnostic structure according to claim 1, further comprising a door opening / closing control unit that controls at least one of the pre-processing space side door unit and the analysis space side door unit so that either the pre-processing space side connecting passage or the analysis space side connecting passage is opened and the other one remains closed. Claim 12 In claim 1, the inlet module includes a door portion for opening and closing an opening for the inlet module, and the opening opens an inlet module formed in the housing, a movable diagnostic structure. Claim 13 A movable diagnostic structure according to claim 12, wherein the inlet module further comprises an ultraviolet irradiation unit that irradiates ultraviolet rays toward the inlet module opening when the inlet module opening is opened by the door unit, and / or an air curtain that blocks airflow through the inlet module opening between the outside and the pre-processing space. Claim 14 A movable diagnostic structure according to claim 1, wherein the inlet module comprises an intermediate chamber providing a predetermined space for the raw sample to be placed, an external door portion for opening and closing a connecting passage between the outside and the intermediate chamber, and a preprocessing space side door portion for opening and closing a connecting passage between the intermediate chamber and the preprocessing space. Claim 15 In claim 14, the inlet module further comprises a UV irradiation unit that irradiates ultraviolet rays toward the interior of the intermediate chamber, a movable diagnostic structure. Claim 16 A mobile diagnostic structure according to claim 14, wherein the inlet module further comprises a pressure control unit that adjusts the internal pressure of the intermediate chamber relative to the external pressure or the internal pressure of the pre-processing space. Claim 17 A movable diagnostic structure according to claim 16, wherein the pressure control unit controls the internal pressure of the intermediate chamber to be equal to the internal pressure of the pretreatment space while the external connection passage is blocked by the external door unit and the pretreatment space side connection passage is open by the pretreatment space side door unit, and controls the internal pressure of the intermediate chamber to be equal to the external pressure while the external connection passage is open by the external door unit and the pretreatment space side connection passage is blocked by the pretreatment space side door unit. Claim 18 A movable diagnostic structure according to claim 1, further comprising a first access module that provides a first access path used by the processor when moving between the outside and the preprocessing space. Claim 19 In claim 18, the first access module comprises a door portion for opening and closing an opening for the first access module, and the opening opens the first access module formed in the housing, a movable diagnostic structure. Claim 20 A movable diagnostic structure according to claim 19, wherein the first access module further comprises an ultraviolet irradiation unit that irradiates ultraviolet rays toward the opening for the first access module when the opening for the first access module is opened by the door unit, and / or an air curtain that blocks airflow through the opening for the first access module between the outside and the pretreatment. Claim 21 In claim 18, the first access module comprises an intermediate chamber providing a space for the processor, an external door portion for opening and closing a connecting passage between the outside and the intermediate chamber, and a pre-processing space side door portion for opening and closing a connecting passage between the intermediate chamber and the pre-processing space, forming a movable diagnostic structure. Claim 22 In claim 21, the first entry / exit module further comprises a UV irradiation unit that irradiates ultraviolet rays toward the interior of the intermediate chamber, a movable diagnostic structure. Claim 23 A mobile diagnostic structure according to claim 21, wherein the first entry / exit module further comprises a pressure control unit that adjusts the internal pressure of the intermediate chamber relative to the external pressure or the internal pressure of the pre-processing space. Claim 24 A movable diagnostic structure according to claim 23, wherein the pressure control unit controls the internal pressure of the intermediate chamber to be equal to the internal pressure of the pretreatment space while the external connection passage is blocked by the external door unit and the pretreatment space side connection passage is open by the pretreatment space side door unit, and controls the internal pressure of the intermediate chamber to be equal to the external pressure while the external connection passage is open by the external door unit and the pretreatment space side connection passage is blocked by the pretreatment space side door unit. Claim 25 In claim 23, the pressure control unit is a movable diagnostic structure that controls the internal pressure of the intermediate chamber to be lower than the external pressure and higher than the internal pressure of the pretreatment space while both the external connecting passage and the pretreatment space connecting passage are opened by the external door unit and the pretreatment space door unit. Claim 26 In claim 18, a movable diagnostic structure in which the inlet path and the first entry / exit path are positioned so as not to overlap each other. Claim 27 A mobile diagnostic structure according to claim 18, further comprising a second access module that provides a second access path used by the processor when moving between the outside and the analysis space. Claim 28 In claim 27, the second access module comprises: an opening for the second access module formed in the housing; and a door portion for opening and closing the opening for the second access module, forming a movable diagnostic structure. Claim 29 A movable diagnostic structure according to claim 28, wherein the second access module further comprises an ultraviolet irradiation unit that irradiates ultraviolet rays toward the opening for the second access module when the opening for the second access module is opened by the door unit, and / or an air curtain that blocks the airflow between the outside and the pretreatment through the opening for the second access module. Claim 30 In claim 27, the second access module comprises an intermediate chamber providing a space for the processor, an external door portion opening and closing a connecting passage between the outside and the intermediate chamber, and an analysis space side door portion opening and closing a connecting passage between the intermediate chamber and the analysis space, forming a movable diagnostic structure. Claim 31 In claim 30, the mobile diagnostic structure further comprises a second entry / exit module that irradiates ultraviolet rays toward the interior of the intermediate chamber. Claim 32 A mobile diagnostic structure according to claim 30, wherein the second entry / exit module further comprises a pressure control unit that adjusts the internal pressure of the intermediate chamber relative to the external pressure or the internal pressure of the analysis space. Claim 33 A movable diagnostic structure according to claim 32, wherein the pressure control unit controls the internal pressure of the intermediate chamber to be equal to the internal pressure of the analysis space while the external connection passage is blocked by the external door unit and the analysis space connection passage is open by the analysis space door unit, and controls the internal pressure of the intermediate chamber to be equal to the external pressure while the external connection passage is open by the external door unit. Claim 34 In claim 32, the pressure control unit is a movable diagnostic structure that controls the internal pressure of the intermediate chamber to be higher than the external pressure and lower than the internal pressure of the analysis space while the external connecting passage and the analysis space connecting passage are opened by the external door unit and the analysis space door unit. Claim 35 In claim 27, the above-mentioned inlet path and the above-mentioned second entry / exit path are positioned so as not to overlap each other when viewed from the top of the above-mentioned mobile diagnostic structure. Claim 36 A movable diagnostic structure according to claim 27, wherein the first access module is provided in the preprocessing space and the second access module is provided in the analysis space, and the first access module and the second access module are arranged to come into contact with each other with the partition module in between. Claim 37 In claim 1, a raw sample unpacking unit, a first dispensing device, and a nucleic acid extraction device are disposed in the preprocessing space, and a second dispensing device, an additional work device, and an analysis device are disposed in the analysis space, and the mobile diagnostic structure further comprises a calibration notification unit that indicates that calibration is required for at least one of the raw sample unpacking unit, the first dispensing device, the nucleic acid extraction device, the second dispensing device, the additional work device, and the analysis device when a predetermined condition is satisfied. Claim 38 In claim 37, the mobile diagnostic structure further comprises a vibration detection module that detects vibration transmitted to at least one of the preprocessing space and the analysis space, and the calibration notification unit determines whether the condition is satisfied based on at least one of the magnitude of the detected vibration and the length of time during which the vibration is detected or not detected. Claim 39 delete Claim 40 In claim 1, the intake portion is a movable diagnostic structure positioned vertically above the detection device. Claim 41 A movable diagnostic structure according to claim 1, wherein the air sucked into the intake portion comprises air used for cooling the detection device while the internal space of the detection device is closed to the analysis space, and air flowing out from the internal space while the internal space of the detection device is open to the analysis space. Claim 42 A movable diagnostic structure according to claim 1, wherein the amount of air sucked into the intake portion is relatively large while the internal space of the detection device is open to the analysis space compared to while the internal space of the detection device is closed to the analysis space. Claim 43 delete Claim 44 A movable diagnostic structure according to claim 1, wherein the rack further comprises a front wall surrounding at least a portion of the front of the detection device so as to guide the flow of air exiting from the detection device toward the intake portion. Claim 45 A movable diagnostic structure according to claim 1, wherein the rack further comprises a second mounting plate disposed vertically above the first mounting plate on which an additional detection device is mounted, and the side wall surrounds at least a portion of the side surface of the additional detection device to guide the flow of air that may flow out from the additional detection device. Claim 46 A movable diagnostic structure according to claim 45, wherein the second mounting plate comprises a support portion supporting the additional detection device and a predetermined opening, and air from the detection device mounted on the first mounting plate passes through the opening and is sucked into the intake portion. Claim 47 In claim 1, the sample collection space is further provided in the space, and the sample collection activity is performed on a sample provider located outside the housing while a sample collector stays in the sample collection space, the inlet module is a mobile diagnostic structure. Claim 48 In claim 47, the sample collection space is provided within the pre-processing space, so that the sample collector can move between the sample collection space and the pre-processing space, a movable diagnostic structure. Claim 49 In claim 47, the mobile diagnostic structure wherein the space is partitioned by the partition module into the sample collection space, the preprocessing space, and the analysis space. Claim 50 In claim 47, the mobile diagnostic structure further comprises a glove wall disposed between the space where the sample provider stays when the sample collection act is performed and the sample collection space, wherein the glove wall comprises a glove wearable on the arm of the sample collector. Claim 51 In claim 50, the mobile diagnostic structure further comprises a sample temporary storage unit for temporarily storing at least one raw sample, including a raw sample taken from the sample provider, wherein the sample temporary storage unit is placed in a space where the sample provider stays. Claim 52 A movable diagnostic structure according to claim 51, wherein the sample temporary storage unit comprises at least one of a door for opening and closing the interior, a UV irradiation unit for irradiating ultraviolet light toward a tube containing each of at least one raw sample while the interior is closed by the door, and / or a disinfectant spray unit for spraying disinfectant toward each of the tubes. Claim 53 A mobile diagnostic structure according to claim 1, wherein the partition module partitions the space to include a sample collection space, a preprocessing space, and an analysis space, and the transfer module comprises a first transfer module providing a first transfer path from the sample collection space to the preprocessing space for a raw sample sampled in the sample collection space, and a second transfer module providing a second transfer path from the preprocessing space to the analysis space for a preprocessed sample which is a result of the raw sample being preprocessed in the preprocessing space. Claim 54 A diagnostic vehicle comprising: a mobile diagnostic structure according to any one of claims 1 to 5, 7, 10 to 42, and 44 to 53; and a vehicle connected to the mobile diagnostic structure. Claim 55 In Clause 54, the vehicle is a diagnostic vehicle that is a vibration-free vehicle.

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