Compound with improved transdermal absorption rate and high temperature stability

Abstract

The present invention relates to a cosmetic composition comprising resiliencesomes with improved transdermal absorption rate and high-temperature stability, characterized by including a carrier component; liposomes captured by an amphiphilic surfactant and niosomes captured by a nonionic surfactant, and further including an anionic surfactant, polyhydric alcohol, fatty acid, and phytosterol to improve transdermal absorption rate and high-temperature stability.

Description

Technology Field

[0001] The present invention relates to a cosmetic composition comprising a composite having improved transdermal absorption rate and high temperature stability, and more specifically, to a cosmetic composition comprising a composite having improved transdermal absorption rate and high temperature stability, wherein the mixture comprising a carrier component and purified water simultaneously comprises a liposome captured by an amphiphilic surfactant and a niosome captured by a nonionic surfactant, and wherein the mixture further comprises an anionic surfactant, a polyhydric alcohol, a fatty acid, and a phytosterol to improve transdermal absorption rate and high temperature stability. Background Technology

[0002] Various functional substances are being developed as cosmetic compositions to increase effective skin absorption rates, but there are cases where their use is restricted due to the stability of raw materials. One of these is beta-sitosterol, a type of plant sterol found in plants such as margarine, rice bran, legumes, pumpkin seeds, and corn. Although it is known to have effects such as skin cell repair, it has been difficult to use it as a cosmetic composition due to its characteristic of not dissolving well in water-soluble and fat-soluble solvents.

[0003] In order to utilize the aforementioned poorly soluble substances in cosmetic compositions, conventional methods were attempted to manufacture them in the structure of liposomes or niosomes, but there was a problem with insufficient long-term stability.

[0004] In order to solve the problems of the conventional technology, the inventors of the present invention, after continuing strenuous efforts, succeeded in developing a Flexosome that possesses the characteristics of both liposomes and niosomes while having excellent skin absorption rate.

[0005] Accordingly, the applicant disclosed "a flex micelle structure composition with excellent transdermal absorption rate and a method for manufacturing the same" in Korean Registered Patent Publication No. 10-2632205 (published on February 5, 2024), which relates to a cosmetic composition comprising a micelle structure including lecithin, glycerin, sodium surpectin, polyglyceryl-10 laurate, cholesterol, and beta-sitosterol.

[0006] However, the composition according to the above-mentioned conventional "flex micelle structure composition with excellent transdermal absorption rate and method for manufacturing the same" lacks transdermal absorption rate and high-temperature stability. Accordingly, a cosmetic composition having improved transdermal absorption rate and high-temperature stability was manufactured. Prior art literature

[0007] Korean Registered Patent Publication No. 10-2632205 (Published Feb. 5, 2024), "Flex micelle structure composition with excellent transdermal absorption rate and method for manufacturing the same" The problem to be solved

[0008] To achieve the above objectives, the present invention aims to provide a cosmetic composition comprising a composite with improved transdermal absorption rate and high-temperature stability, characterized by including a carrier component; a liposome captured by an amphiphilic surfactant and a niosome captured by a nonionic surfactant, and further including an anionic surfactant, a polyalcohol, a fatty acid, and a phytosterol to improve transdermal absorption rate and high-temperature stability. means of solving the problem

[0009] To achieve the above objectives, the present invention provides a cosmetic composition comprising a composite with improved transdermal absorption rate and high-temperature stability, characterized in that the mixture comprising a carrier component and purified water simultaneously comprises a liposome captured by an amphiphilic surfactant and a niosome captured by a nonionic surfactant, wherein the mixture further comprises an anionic surfactant, a polyhydric alcohol, a fatty acid, and a phytosterol to improve transdermal absorption rate and high-temperature stability.

[0010] delete

[0011] delete

[0012] At this time, the polyalcohol is characterized by being one or more selected from the group consisting of lauryl alcohol, myristyl alcohol, cetyl alcohol, cetearyl alcohol, behenyl alcohol, and arachidyl alcohol.

[0013] At this time, the fatty acid is characterized by being one or more selected from the group consisting of caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, and lignoceric acid.

[0014] delete

[0015] At this time, the phytosterol is characterized by being one or more selected from the group consisting of rapeseed sterol, sitosterol, ergosterol, campesterol, stigmasterol, and fucosterol. Effects of the invention

[0016] A cosmetic composition according to the present invention, comprising a composite having improved transdermal absorption rate and high-temperature stability, comprises a mixture comprising a carrier component and purified water, a liposome captured by an amphiphilic surfactant, and a niosome captured by a nonionic surfactant; wherein the mixture further comprises an anionic surfactant, a polyalcohol, a fatty acid, and a phytosterol, thereby having a transdermal absorption rate and high-temperature stability. Brief explanation of the drawing

[0017] FIG. 1 is a flowchart briefly illustrating a process for preparing a cosmetic composition containing resiliencesomes with improved transdermal absorption rate and high-temperature stability according to the present invention. Specific details for implementing the invention

[0018] The following detailed descriptions relating to the present invention are embodiments in which the present invention can be practiced, and reference is made to the accompanying drawings illustrated as examples of such embodiments. These embodiments are described in detail to sufficiently enable those skilled in the art to practice the present invention.

[0019] It should be understood that various embodiments of the present invention are different but need not be mutually exclusive.

[0020] For example, specific shapes, structures, and characteristics described herein may be implemented in other embodiments without departing from the spirit and scope of the invention in relation to one embodiment.

[0021] In addition, it should be understood that the location or arrangement of individual components within each described embodiment may be changed without departing from the spirit and scope of the invention.

[0022] Therefore, the following detailed description is not intended to be taken in a limiting sense, and the scope of the invention is limited only by the appended claims, including all equivalents to those claimed therein, provided they are properly described.

[0023] In drawings, similar reference numerals refer to the same or similar functions across multiple aspects.

[0024] The terms used in this invention have been selected based on currently widely used general terms, taking into account their functions within the invention; however, these terms may vary depending on the intent of those skilled in the art, case law, the emergence of new technologies, etc. Additionally, in specific cases, terms have been arbitrarily selected by the applicant, and in such cases, their meanings will be described in detail in the relevant description of the invention. Therefore, the terms used in this invention should be defined not merely by their names, but based on their meanings and the overall content of the invention.

[0025] In the present invention, when a part is described as “comprising” a certain component, this means that, unless specifically stated otherwise, it does not exclude other components but may include additional components.

[0027] Hereinafter, a cosmetic composition containing resilience somes with improved transdermal absorption rate and high-temperature stability according to the present invention will be described in detail.

[0028] "Resiliencesome" is a term arbitrarily selected by the applicant and refers to a nanoemulsion or complex comprising both liposomes and niosomes.

[0030] A cosmetic composition according to the present invention comprising resiliencesomes with improved transdermal absorption rate and high-temperature stability comprises a mixture comprising a carrier component and purified water, and simultaneously comprises a liposome captured by an amphiphilic surfactant and a niosome captured by a nonionic surfactant, wherein the mixture further comprises an anionic surfactant, a polyalcohol, a fatty acid, and a phytosterol to improve transdermal absorption rate and high-temperature stability.

[0032] The above carrier component may include various components such as known polyols, oils, thickeners, preservatives, neutralizing agents, solid oils, coloring agents, purified water, etc. As an example, polyols include propanediol, butanediol, pentanediol, hexanediol, pentylene glycol, methylpropanediol, sorbitol, diglycerin, erythritol, pentaerythritol, polybutylene glycol-10, polyglycerin-3, polyglycerin-4, polyglycerin-6, polyglycerin-10, polyglycerin-20, polyglycerin-40, sorbes-5, sorbes-6, sorbes-20, sorbes-30, sorbes-40, inositol, maltitol, maltose, mannan, mannitol, mannose, lactitol, lactose, dihydroxypropyl PG-glucoside, dithioctenidiol, fructose, glucamine, methylglucamine, glucose, 1,6-hexanediol, methylgluceth-10, Methylgluceth-20, ozonized glycerin, phytantriol, thioglycerin, threitol, trimethylolpropane, xylitol, dipropylene glycol, butylene glycol, glycerin, 1,2-hexanediol, caprylyl glycol, etc. may be used.For example, oil components include camellia seed oil, canola oil, argan kernel oil, avocado oil, castor seed oil, grape seed oil, sunflower seed oil, macadamia seed oil, rosemary leaf oil, lavender oil, evening primrose oil, apricot kernel oil, lemon-scented tea tree oil, baobab seed oil, babassu seed oil, drumstick seed oil, acai palm fruit oil, eucalyptus leaf oil, jojoba seed oil, orange blossom oil, orange oil, Philippine orange peel oil, cedrat peel oil, and olive oil, caprylic / capric triglyceride, dimethicone, bis-diglyceryl polyacyladipate-2, diisostearyl malate, dipentaerythrityl hexahydroxystearate / hexastearate / hexarosinate, Phenyl trimethicone, cetyl ethylhexanoate, octyldodecyl stearoyl stearate, hydrogenated polydecene, neopentyl glycol diheptanoate, propylene glycol dibenzoate, isodecyl neopentanoate, phytosteryl / isostearyl / cetyl / stearyl / behenyl dimer dilinoleate, isononyl isononanoate, hexyl laurate, etc. may be used. As an example, as a thickening agent, xanthan gum, carob gum, carrageenan, cellulose gum, diutan gum, tara gum, gellan gum, dehydroxanthan gum, natto gum, carbomer, ammonium acryloyl dimethyl taurate / VP copolymer, etc. may be used. Examples of preservatives include ethylparaben, butylparaben, chlorphenesin, phenoxyethanol, hydroxyacetphenone, etc. Examples of neutralizing agents include potassium hydroxide, sodium hydroxide, methylglucarmine, triethanolamine, tromethamine, etc. Examples of solid fats include mango butter, parquet butter, cupuaçu butter, murumuru butter, cocoa butter, orange wax, shea butter, etc.As an example, coloring agents may include titanium dioxide (CI 77891), yellow iron oxide, red iron oxide, black iron oxide, Red 202, Red 201, Yellow 5, Yellow 4, ultramarine, manganese violet, blue 1, red 104 (1), chromium oxide green, etc.

[0034] Meanwhile, the cosmetic composition according to the present invention may comprise the carrier component in an amount of 0.1 to 99.3% by weight relative to the total weight of the composition, the amphiphilic surfactant in an amount of 0.1 to 99.3% by weight relative to the total weight of the composition, the nonionic surfactant in an amount of 0.1 to 99.3% by weight relative to the total weight of the composition, the anionic surfactant in an amount of 0.1 to 99.3% by weight relative to the total weight of the composition, the polyalcohol in an amount of 0.1 to 99.3% by weight relative to the total weight of the composition, the fatty acid in an amount of 0.1 to 99.3% by weight relative to the total weight of the composition, the phytosterol in an amount of 0.1 to 99.3% by weight relative to the total weight of the composition, and the purified water in an amount of remainder.

[0035] More specifically, the cosmetic composition according to the present invention may comprise 40.0 to 45.0 weight% of the carrier component relative to the total weight of the composition, 2.0 to 4.0 weight% of the amphiphilic surfactant relative to the total weight of the composition, 1.0 to 2.0 weight% of the nonionic surfactant relative to the total weight of the composition, 0.1 to 1.0 weight% of the anionic surfactant relative to the total weight of the composition, 2.0 to 4.0 weight% of the polyalcohol relative to the total weight of the composition, 0.1 to 2.0 weight% of the fatty acid relative to the total weight of the composition, 0.1 to 2.0 weight% of the phytosterol relative to the total weight of the composition, and the remaining amount of purified water.

[0036] As a most specific example, the cosmetic composition according to the present invention may comprise 42.5% by weight of the carrier component relative to the total weight of the composition, 3.0% by weight of the amphiphilic surfactant relative to the total weight of the composition, 2.0% by weight of the nonionic surfactant relative to the total weight of the composition, 0.5% by weight of the anionic surfactant relative to the total weight of the composition, 3.0% by weight of the polyalcohol relative to the total weight of the composition, 1.0% by weight of the fatty acid relative to the total weight of the composition, 1.0% by weight of the phytosterol relative to the total weight of the composition, and the remaining amount of purified water.

[0037] A cosmetic composition according to the present invention comprising resiliencesomes with improved transdermal absorption rate and high-temperature stability comprises 40.0 to 45.0 weight% of a carrier component and the remainder being purified water based on the total weight of the composition; liposomes captured by 2.0 to 4.0 weight% of an amphiphilic surfactant based on the total weight of the composition and niosomes captured by 1.0 to 2.0 weight% of a nonionic surfactant based on the total weight of the composition, wherein the mixture further comprises 0.1 to 1.0 weight% of an anionic surfactant based on the total weight of the composition, 2.0 to 4.0 weight% of a polyalcohol based on the total weight of the composition, 0.1 to 2.0 weight% of a fatty acid based on the total weight of the composition, and 0.1 to 2.0 weight% of a phytosterol based on the total weight of the composition, thereby improving the transdermal absorption rate and high-temperature stability.

[0038] In other words, a cosmetic composition comprising resiliencesomes with improved transdermal absorption rate and high-temperature stability according to the present invention comprises: a mixture comprising 40.0 to 45.0 weight% of a carrier component, 0.1 to 1.0 weight% of an anionic surfactant, 2.0 to 4.0 weight% of a polyhydric alcohol, 0.1 to 2.0 weight% of a fatty acid, 0.1 to 2.0 weight% of a phytosterol, and the remainder being purified water, to which 2.0 to 4.0 weight% of an amphiphilic surfactant and 1.0 to 2.0 weight% of a nonionic surfactant are added based on the total weight of the composition, and a high-pressure homogenizer (Microfluidizer) is used to obtain a mixture comprising liposomes captured by the amphiphilic surfactant and liposomes captured by the nonionic surfactant It can be manufactured to include niosomes.

[0040] The above-mentioned amphiphilic surfactant is used to form liposomes.

[0041] It is preferable to use one or more of the above-mentioned amphiphilic surfactants selected from the group consisting of a mixture of phosphatidylcholine (PC) and phosphadidylserine; a mixture of phosphatidylcholine (PC) and phosphadidylethanolamine; lecithin; and hydrogenated lecithin.

[0043] The above-mentioned nonionic surfactant is used to form niosomes.

[0044] It is preferable to use one or more of the above-mentioned nonionic surfactants selected from the group consisting of polyglyceryl-2 laurate, polyglyceryl-2 stearate, polyglyceryl-2 oleate, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 methylglucose distearate, polyglyceryl-4 laurate, polyglyceryl-4 isostearate, polyglyceryl-10 stearate, polyglyceryl-10 myristate, polyglyceryl-10 oleate, and polyglyceryl-10 laurate.

[0046] The above anionic surfactant may be included in the above mixture. The above anionic surfactant may be involved in the formation of both liposomes and niosomes. By being involved in the formation of liposomes and niosomes, the above anionic surfactant may help improve transdermal absorption rate and high-temperature stability. It is preferable to use one or more selected from the group consisting of glyceryl oleate citrate, glyceryl stearate citrate, sodium stearoyl lactylate, sodium stearoyl glutamate, and potassium cetyl phosphate as the above anionic surfactant.

[0048] The above polyalcohol may be included in the above mixture. The above polyalcohol may be involved in the formation of both liposomes and niosomes, but is more involved in the formation of niosomes. By being involved in the formation of liposomes and niosomes, the above polyalcohol can help improve transdermal absorption rate and high-temperature stability. It is preferable to use one or more selected from the group consisting of lauryl alcohol, myristyl alcohol, cetyl alcohol, cetearyl alcohol, behenyl alcohol, and arachidyl alcohol as the above polyalcohol.

[0050] The above fatty acid may be included in the above mixture. The above fatty acid may be involved in the formation of both liposomes and niosomes. By being involved in the formation of liposomes and niosomes, the above fatty acid may help improve transdermal absorption rate and high-temperature stability. It is preferable to use one or more selected from the group consisting of caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, and lignoceric acid.

[0052] The above phytosterol may be included in the above mixture. The above phytosterol may be involved in the formation of both liposomes and niosomes, but is more involved in the formation of liposomes. By being involved in the formation of liposomes and niosomes, the above phytosterol may help improve transdermal absorption rate and high-temperature stability. It is preferable to use one or more selected from the group consisting of cauliflower sterol, sitosterol, ergosterol, campesterol, stigmasterol, and fucosterol.

[0054] Meanwhile, a method for preparing a cosmetic composition containing resiliencesomes with improved transdermal absorption rate and high-temperature stability according to the present invention comprises: a mixture preparation step (S10) of preparing a mixture comprising a carrier component in an amount of 0.1 to 99.3% by weight relative to the total weight of the final composition, an anionic surfactant in an amount of 0.1 to 99.3% by weight relative to the total weight of the final composition, a polyalcohol in an amount of 0.1 to 99.3% by weight relative to the total weight of the final composition, a fatty acid in an amount of 0.1 to 99.3% by weight relative to the total weight of the final composition, a phytosterol in an amount of 0.1 to 99.3% by weight relative to the total weight of the final composition, and the remainder being purified water; The method may include: a step of adding an amphiphilic surfactant and a nonionic surfactant (S20), wherein 0.1 to 99.3 weight% of an amphiphilic surfactant and 0.1 to 99.3 weight% of a nonionic surfactant are added to the mixture of the above mixture preparation step (S10) based on the total weight of the final composition; and a step of preparing a cosmetic composition (S30), wherein the cosmetic composition is prepared using a high-pressure homogenizer (Microfluidizer) to include liposomes captured by the amphiphilic surfactant and niosomes captured by the nonionic surfactant.

[0056] In the above mixture preparation step (S10), a mixture is prepared to include 0.1 to 99.3 weight% of a carrier component relative to the total weight of the final composition, 0.1 to 99.3 weight% of an anionic surfactant relative to the total weight of the final composition, 0.1 to 99.3 weight% of a polyalcohol relative to the total weight of the final composition, 0.1 to 99.3 weight% of a fatty acid relative to the total weight of the final composition, 0.1 to 99.3 weight% of a phytosterol relative to the total weight of the final composition, and the remainder being purified water. More specifically, in the mixture preparation step (S10), the mixture may be prepared to include 40.0 to 45.0 weight% of a carrier component relative to the total weight of the final composition, 0.1 to 1.0 weight% of an anionic surfactant relative to the total weight of the final composition, 2.0 to 4.0 weight% of a polyalcohol relative to the total weight of the final composition, 0.1 to 2.0 weight% of a fatty acid relative to the total weight of the final composition, 0.1 to 2.0 weight% of a phytosterol relative to the total weight of the final composition, and the remainder being purified water.

[0057] In the step of adding amphiphilic surfactants and nonionic surfactants (S20), the process of adding 0.1 to 99.3 weight% of an amphiphilic surfactant and 0.1 to 99.3 weight% of a nonionic surfactant to the total weight of the final composition to the mixture of the mixture preparation step (S10) is performed. More specifically, in the step of adding amphiphilic surfactants and nonionic surfactants (S20), the process of adding 2.0 to 4.0 weight% of an amphiphilic surfactant and 1.0 to 2.0 weight% of a nonionic surfactant to the total weight of the final composition to the mixture of the mixture preparation step (S10) is performed.

[0058] In the above cosmetic composition preparation step (S30), a high-pressure homogenizer (Microfluidizer) is used to prepare a cosmetic composition containing liposomes captured by the amphiphilic surfactant and niosomes captured by the nonionic surfactant.

[0060] Hereinafter, the effects of the cosmetic composition according to the present invention will be examined in detail through the following comparative examples and experimental examples.

[0062] Examples 1. Transdermal absorption rate and improved high-temperature stability resilience including fury Preparation of a fermented food composition

[0063] A cosmetic composition was prepared by selecting representative components from among carrier components, anionic surfactants, polyhydric alcohols, fatty acids, phytosterols, purified water, amphiphilic surfactants, and nonionic surfactants.

[0064] According to Table 1 below, a carrier component, an anionic surfactant, a polyalcohol, a fatty acid, a phytosterol, and purified water were mixed, an amphiphilic surfactant and a nonionic surfactant were added, and a high-pressure homogenizer (Microfluidizer) was used to prepare a cosmetic composition containing liposomes captured by the amphiphilic surfactant and niosomes captured by the nonionic surfactant.

[0065] division ingredient Content Carrier component glycerin 10.0 wt% 1,2-hexanediol 1.0 wt% Caprylyl glycol 0.5 wt% Caprylic / Pharyl Triglyceride 30.0 wt% Ammonium Acryloyl Dimethyl Taurate / VP Copolymer 1.0 wt% Anionic surfactants Sodium stearoyl glutamate 0.5 wt% Polyalcohol Cetyl alcohol 1.0 wt% cetearyl alcohol 2.0 wt% fatty acid palmitic acid 0.55 wt% Stearic acid 0.45 wt% Phytosterols Rapeseed sterol 1.0 wt% Amphiphilic surfactants Hydrogenated lecithin 3.0 wt% Nonionic surfactants Polyglyceryl-10 laurate 2.0 wt% purified water Remaining amount

[0067] Comparative Example 2. Preparation of a cosmetic composition excluding anionic surfactants

[0068] A cosmetic composition was prepared by selecting representative components from among carrier components, polyalcohols, fatty acids, phytosterols, purified water, amphiphilic surfactants, and nonionic surfactants.

[0069] According to Table 2 below, a carrier component, polyalcohol, fatty acid, phytosterol, and purified water were mixed, an amphiphilic surfactant and a nonionic surfactant were added, and a high-pressure homogenizer (Microfluidizer) was used to prepare a cosmetic composition containing liposomes captured by the amphiphilic surfactant and niosomes captured by the nonionic surfactant.

[0070] division ingredient Content Carrier component glycerin 10.0 wt% 1,2-hexanediol 1.0 wt% Caprylyl glycol 0.5 wt% Caprylic / Pharyl Triglyceride 30.0 wt% Ammonium Acryloyl Dimethyl Taurate / VP Copolymer 1.0 wt% Polyalcohol Cetyl alcohol 1.0 wt% cetearyl alcohol 2.0 wt% fatty acid palmitic acid 0.55 wt% Stearic acid 0.45 wt% Phytosterols Rapeseed sterol 1.0 wt% Amphiphilic surfactants Hydrogenated lecithin 3.0 wt% Nonionic surfactants Polyglyceryl-10 laurate 2.0 wt% purified water Remaining amount

[0072] Comparative Example 3. Preparation of a cosmetic composition excluding polyalcohols

[0073] A cosmetic composition was prepared by selecting representative components from among carrier components, anionic surfactants, fatty acids, phytosterols, purified water, amphiphilic surfactants, and nonionic surfactants.

[0074] According to Table 3 below, a carrier component, an anionic surfactant, a fatty acid, a phytosterol, and purified water were mixed, an amphiphilic surfactant and a nonionic surfactant were added, and a high-pressure homogenizer (Microfluidizer) was used to prepare a cosmetic composition containing liposomes captured by the amphiphilic surfactant and niosomes captured by the nonionic surfactant.

[0075] division ingredient Content Carrier component glycerin 10.0 wt% 1,2-hexanediol 1.0 wt% Caprylyl glycol 0.5 wt% Caprylic / Pharyl Triglyceride 30.0 wt% Ammonium Acryloyl Dimethyl Taurate / VP Copolymer 1.0 wt% Anionic surfactants Sodium stearoyl glutamate 0.5 wt% fatty acid palmitic acid 0.55 wt% Stearic acid 0.45 wt% Phytosterols Rapeseed sterol 1.0 wt% Amphiphilic surfactants Hydrogenated lecithin 3.0 wt% Nonionic surfactants Polyglyceryl-10 laurate 2.0 wt% purified water Remaining amount

[0077] Comparative Example 4. Preparation of a cosmetic composition excluding fatty acids

[0078] A cosmetic composition was prepared by selecting representative components from among carrier components, anionic surfactants, polyhydric alcohols, phytosterols, purified water, amphiphilic surfactants, and nonionic surfactants.

[0079] According to Table 4 below, a carrier component, an anionic surfactant, a polyalcohol, a phytosterol, and purified water were mixed, an amphiphilic surfactant and a nonionic surfactant were added, and a high-pressure homogenizer (Microfluidizer) was used to prepare a cosmetic composition containing liposomes captured by the amphiphilic surfactant and niosomes captured by the nonionic surfactant.

[0080] division ingredient Content Carrier component glycerin 10.0 wt% 1,2-hexanediol 1.0 wt% Caprylyl glycol 0.5 wt% Caprylic / Pharyl Triglyceride 30.0 wt% Ammonium Acryloyl Dimethyl Taurate / VP Copolymer 1.0 wt% Anionic surfactants Sodium stearoyl glutamate 0.5 wt% Polyalcohol Cetyl alcohol 1.0 wt% cetearyl alcohol 2.0 wt% Phytosterols Rapeseed sterol 1.0 wt% Amphiphilic surfactants Hydrogenated lecithin 3.0 wt% Nonionic surfactants Polyglyceryl-10 laurate 2.0 wt% purified water Remaining amount

[0082] Comparative Example 5. Preparation of a cosmetic composition excluding phytosterols

[0083] A cosmetic composition was prepared by selecting representative components from among carrier components, anionic surfactants, polyhydric alcohols, fatty acids, purified water, amphiphilic surfactants, and nonionic surfactants.

[0084] According to Table 5 below, a carrier component, an anionic surfactant, a polyalcohol, a fatty acid, and purified water were mixed, an amphiphilic surfactant and a nonionic surfactant were added, and a high-pressure homogenizer (Microfluidizer) was used to prepare a cosmetic composition containing liposomes captured by the amphiphilic surfactant and niosomes captured by the nonionic surfactant.

[0085] division ingredient Content Carrier component glycerin 10.0 wt% 1,2-hexanediol 1.0 wt% Caprylyl glycol 0.5 wt% Caprylic / Pharyl Triglyceride 30.0 wt% Ammonium Acryloyl Dimethyl Taurate / VP Copolymer 1.0 wt% Anionic surfactants Sodium stearoyl glutamate 0.5 wt% Polyalcohol Cetyl alcohol 1.0 wt% cetearyl alcohol 2.0 wt% fatty acid palmitic acid 0.55 wt% Stearic acid 0.45 wt% Amphiphilic surfactants Hydrogenated lecithin 3.0 wt% Nonionic surfactants Polyglyceryl-10 laurate 2.0 wt% purified water Remaining amount

[0087] Comparative Example 6. Preparation of a cosmetic composition excluding amphiphilic surfactants

[0088] A cosmetic composition was prepared by selecting representative components from among a carrier component, anionic surfactant, polyhydric alcohol, fatty acid, phytosterol, purified water, and nonionic surfactant.

[0089] According to Table 6 below, a carrier component, an anionic surfactant, a polyalcohol, a fatty acid, a phytosterol, and purified water were mixed, a nonionic surfactant was added, and a cosmetic composition containing only niosomes captured by the nonionic surfactant was prepared using a high-pressure homogenizer (Microfluidizer).

[0090] division ingredient Content Carrier component glycerin 10.0 wt% 1,2-hexanediol 1.0 wt% Caprylyl glycol 0.5 wt% Caprylic / Pharyl Triglyceride 30.0 wt% Ammonium Acryloyl Dimethyl Taurate / VP Copolymer 1.0 wt% Anionic surfactants Sodium stearoyl glutamate 0.5 wt% Polyalcohol Cetyl alcohol 1.0 wt% cetearyl alcohol 2.0 wt% fatty acid palmitic acid 0.55 wt% Stearic acid 0.45 wt% Phytosterols Rapeseed sterol 1.0 wt% Nonionic surfactants Polyglyceryl-10 laurate 2.0 wt% purified water Remaining amount

[0092] Comparative Example 7. Preparation of a cosmetic composition excluding nonionic surfactants

[0093] A cosmetic composition was prepared by selecting a representative component from among a carrier component, an anionic surfactant, polyhydric alcohol, fatty acid, phytosterol, purified water, and an amphiphilic surfactant.

[0094] According to Table 7 below, a carrier component, an anionic surfactant, a polyalcohol, a fatty acid, a phytosterol, and purified water were mixed, an amphiphilic surfactant was added, and a cosmetic composition containing only liposomes captured by the amphiphilic surfactant was prepared using a high-pressure homogenizer (Microfluidizer).

[0095] division ingredient Content Carrier component glycerin 10.0 wt% 1,2-hexanediol 1.0 wt% Caprylyl glycol 0.5 wt% Caprylic / Pharyl Triglyceride 30.0 wt% Ammonium Acryloyl Dimethyl Taurate / VP Copolymer 1.0 wt% Anionic surfactants Sodium stearoyl glutamate 0.5 wt% Polyalcohol Cetyl alcohol 1.0 wt% cetearyl alcohol 2.0 wt% fatty acid palmitic acid 0.55 wt% Stearic acid 0.45 wt% Phytosterols Rapeseed sterol 1.0 wt% Amphiphilic surfactants Hydrogenated lecithin 3.0 wt% purified water Remaining amount

[0097] Experimental Example 1. Transdermal absorption rate Verification experiment

[0098] Skin penetration tests were conducted on the compositions of Example 1 and Comparative Examples 1 to 7 prepared above under sink conditions using a Franz diffusion cell (effective area: 0.64 cm², volume of the receiving chamber: 5 ml). To increase the solubility of oleanolic acid, the aqueous phase was prepared by mixing 10% ethanol and 10% PEG-60 hydrogenated castor oil in phosphate buffered saline (PBS) at pH 7.4. A prepared epidermal layer of human skin (1.5 cm x 1.5 cm) was placed on the receptor chamber with the stratum corneum facing upward, the donor chamber was covered and secured with a clamp, the aqueous phase was filled into the Franz diffusion cell, and the temperature was maintained at 32 ± 1 ℃. Permeation tests were conducted by applying 100 µl of each of the compositions of Example 1 and Comparative Examples 1 to 7 prepared above to the donor site. After 24 hours had passed since the permeation test, 5 ml of the aqueous phase was collected and analyzed, and the sample was replaced with a new aqueous phase. The skin samples were purchased from Hans Biomed and stored at -20°C after purchase. Before use, the samples were washed and hydrated in phosphate-buffered saline for 30 minutes. HPLC was used for analysis. For the analysis conditions of the indicator component ammonium acryloyldimethyltaurate / VP copolymer of Example 1 and Comparative Examples 1 to 7, an 82:18 mixture of methanol and 0.1% phosphoric acid was used as the mobile phase, the column was a Waters SunFire™ C18 reverse-phase column (Waters, 4.6 x 250 mm, 5 μm), the injection volume was 20 μl, the flow rate was 1.0 ml / min, and the detection wavelength was 210 nm; the results are shown in Table 8 below.

[0099] Cumulative transdermal absorption rate (%) relative to drop amount after 24 hours Example 1 7.229 Comparative Example 1 5.503 Comparative Example 2 6.437 Comparative Example 3 6.729 Comparative Example 4 5.461 Comparative Example 5 5.581 Comparative Example 6 4.338 Comparative Example 7 4.125

[0100] As a result, it was confirmed that the cumulative transdermal absorption rate of Example 1, which includes all components according to the present invention, was excellent. Meanwhile, in the case of Comparative Examples 1 to 7, in which some components were excluded, the cumulative transdermal absorption rate was relatively low, and in particular, Comparative Examples 6 and 7, in which only liposomes or only niosomes were formed, showed significantly low cumulative transdermal absorption rates.

[0102] Experimental Example 2. High-temperature stability verification experiment

[0103] The uniformity at high temperatures was evaluated by comparing the emulsion particles of the cosmetic compositions prepared in Example 1 and Comparative Examples 1 to 7 using an optical microscope, and the emulsion stability was tested by evaluating the separation state after leaving the compositions for 3 months under constant temperature conditions of 4°C and 40°C and under circulating conditions where the temperature was changed twice a day from -4°C to 40°C, and the results are shown in Tables 9 and 10.

[0104] Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 45℃ for 1 week, particle size (nm) 53.42 54.23 53.47 53.04 54.36 54.19 54.54 53.38 45℃ for 3 months, particle size (nm) 55.25 74.34 72.52 71.25 75.12 76.73 84.52 88.28

[0105] Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 4℃ 1 month ○ ○ ○ ○ ○ ○ △ △ 2 months ○ △ △ △ △ △ △ △ 3 months ○ △ △ △ △ △ △ △ 40℃ 1 month ○ △ △ △ △ △ △ × 2 months ○ △ △ △ △ △ × × 3 months ○ × × × × × × × -4℃~40℃ circulation 1 month ○ △ ○ ○ △ △ △ △ 2 months ○ △ △ △ △ △ × × 3 months △ × × × × × × × ○ : Good, △ : Average, × : Separable, Unmeasurable

[0106] As a result, as can be seen in Tables 8 and 9 above, it was confirmed that the high-temperature stability of Example 1 was excellent and the formed particle size was maintained uniformly. In addition, as can be seen in Comparative Examples 1 to 7, it was confirmed that when some components were missing, the stability at high temperatures decreased significantly and the particle size also changed significantly. In particular, it was confirmed that Comparative Examples 6 and 7, in which only liposomes or only niosomes were formed, exhibited significantly lower high-temperature stability.

[0108] conclusion,

[0109] Through Experimental Examples 1 and 2, which were performed using the cosmetic compositions prepared in Example 1 and Comparative Examples 1 to 9 above, the effects of the cosmetic composition according to the present invention were examined.

[0110] Through Experimental Example 1, it was confirmed that the cumulative transdermal absorption rate of Example 1, which includes all components according to the present invention, was excellent. Meanwhile, in the case of Comparative Examples 1 to 7, which excluded some components, the cumulative transdermal absorption rate was relatively low, and in particular, Comparative Examples 6 and 7, in which only liposomes or only niosomes were formed, were confirmed to show significantly low cumulative transdermal absorption rates.

[0111] Through Experimental Example 2, it was confirmed that the high-temperature stability of Example 1 was excellent and that the formed particles were maintained uniformly. In addition, as can be seen in Comparative Examples 1 to 7, it was confirmed that stability at high temperatures decreased significantly when some components were excluded. In particular, Comparative Examples 6 and 7, in which only liposomes or only niosomes were formed, were confirmed to exhibit significantly lower high-temperature stability.

[0113] Accordingly, the present invention specifies that a cosmetic composition comprising resiliencesomes with improved transdermal absorption rate and high-temperature stability has been developed, characterized by including a carrier component comprising liposomes captured by an amphiphilic surfactant and niosomes captured by a nonionic surfactant, and further including an anionic surfactant, polyhydric alcohol, fatty acid, and phytosterol to improve transdermal absorption rate and high-temperature stability.

[0115] Although the present invention has been described together with the accompanying drawings, this is merely one example among various embodiments containing the gist of the invention, and its purpose is to enable those skilled in the art to easily implement it; it is clear that the present invention is not limited to the embodiments described above. Accordingly, the scope of protection of the present invention should be interpreted by the claims below, and all technical ideas within an equivalent scope by modification, substitution, replacement, etc., without departing from the gist of the invention shall be included within the rights of the present invention. Furthermore, it is clarified that some components in the drawings are provided in an exaggerated or reduced size compared to the actual form to more clearly explain the configuration. Explanation of the symbols

[0116] (S10): Mixture preparation step (S20): Step of adding amphiphilic surfactants and nonionic surfactants (S30): Step for manufacturing a cosmetic composition

Claims

Claim 1 A mixture comprising a carrier component and purified water, and simultaneously comprising a liposome captured by an amphiphilic surfactant of hydrogenated lecithin and a niosome captured by a nonionic surfactant of polyglyceryl-10 laurate; wherein the mixture further comprises an anionic surfactant of sodium stearoyl glutamate, a polyalcohol, a fatty acid, and a phytosterol to improve transdermal absorption rate and high-temperature stability, comprising: a mixture preparation step (S10) of preparing a mixture comprising a carrier component, an anionic surfactant of sodium stearoyl glutamate, a polyalcohol, a fatty acid, a phytosterol, and purified water; and an amphiphilic surfactant and nonionic surfactant addition step (S20) of adding an amphiphilic surfactant of hydrogenated lecithin and a nonionic surfactant of polyglyceryl-10 laurate to the mixture. A cosmetic composition comprising a composite with improved transdermal absorption rate and high-temperature stability, prepared through a cosmetic composition preparation step (S30) of preparing a cosmetic composition containing liposomes captured by the amphiphilic surfactant and niosomes captured by the nonionic surfactant using a high-pressure homogenizer. Claim 2 delete Claim 3 delete Claim 4 delete Claim 5 A cosmetic composition comprising a complex having improved transdermal absorption rate and high-temperature stability, characterized in that, in claim 1, the polyalcohol is one or more selected from the group consisting of lauryl alcohol, myristyl alcohol, cetyl alcohol, cetearyl alcohol, behenyl alcohol, and arachidyl alcohol. Claim 6 A cosmetic composition comprising a complex having improved transdermal absorption rate and high-temperature stability, characterized in that, in claim 1, the fatty acid is one or more selected from the group consisting of caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, and lignoceric acid. Claim 7 A cosmetic composition comprising a complex having improved transdermal absorption rate and high-temperature stability, characterized in that, in claim 1, the phytosterol is one or more selected from the group consisting of rapeseed sterol, sitosterol, ergosterol, campesterol, stigmasterol, and fucosterol.

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