Emulsion composition with preservative stability or synergistic effect about preservation

Abstract

The present invention relates to an emulsion composition comprising 1,2-heptanediol and an emulsifier. When 1,2-heptanediol, which is a preservative component, and a specific emulsifier are combined in appropriate amounts, preservative stability is achieved or a synergistic preservative effect against specific strains is exhibited, thereby enabling optimal effects to be achieved with a small amount of preservative. Furthermore, the emulsion composition according to the present invention can be safely used on the human body.

Description

Technology Field

[0001] The present invention relates to an emulsion composition having preservative stability or a synergistic effect, specifically an emulsion composition in which preservative power is maintained or a synergistic effect is achieved by combining 1,2-heptanediol and an emulsifier. Background Technology

[0002] Cosmetics are primarily composed of oil or water and contain, in particular, glycerin or sorbitol, which serve as carbon sources for microorganisms, as well as amino acid derivatives and proteins, which serve as nitrogen sources. Therefore, just like food, cosmetics are susceptible to penetration by microorganisms such as mold and bacteria. Furthermore, because cosmetics have a relatively longer shelf life than food and are highly susceptible to contamination by microorganisms introduced from sources such as fingers, the use of preservatives is essential to prevent the proliferation of microorganisms and to ensure the shelf life and stability of the product.

[0003] However, preservatives pose problems such as allergic reactions, the potential for endocrine disruptors, and the induction of resistance, leading to increasing consumer anxiety regarding their excessive use. In response to these concerns, the cosmetics industry is using 1,2-alkanediol as a substitute for preservatives, such as parabens, which are subject to controversy regarding their harmfulness. 1,2-alkanediol possesses excellent antibacterial effects and has the advantage of superior skin safety compared to other preservatives. However, since 1,2-alkanediol is an amphiphilic substance containing both hydrophobic and hydrophilic properties, when added to cosmetic compositions that typically contain emulsifiers, a problem may arise where its efficacy as a preservative is reduced due to interactions with the emulsifiers.

[0004] Accordingly, the inventors of the present invention made efforts to develop a preservation system that can have preservation stability and synergistic preservation effects without reducing the preservative efficacy in emulsion formulations most commonly used in cosmetics, and completed the present invention by confirming that using a combination of 1,2-heptanediol and a specific emulsifier exhibits preservation stability and synergistic preservation effects. Prior art literature

[0005] (Patent Document 0001) KR 10-2023-0004975 A The problem to be solved

[0006] The present invention aims to provide an emulsion composition having preservative stability or a synergistic effect.

[0007] The technical problems of the present invention are not limited to those mentioned above, and other unmentioned technical problems will be clearly understood by those skilled in the art from the description below. means of solving the problem

[0008] According to an embodiment of the present invention, an emulsion composition comprising 1,2-heptanediol and an emulsifier is provided.

[0009] In addition, the emulsifier may include at least one of polyglyceryl-3 distearate* glyceryl stearate citrate and glyceryl stearate / PEG-100 stearate.

[0010] In addition, the above emulsion composition may have antibacterial activity against at least one of bacteria and fungi.

[0011] In addition, the above emulsion composition may have a synergistic preservative effect against fungi.

[0012] According to another embodiment of the present invention, a cosmetic composition comprising the emulsion composition is provided. Effects of the invention

[0013] The emulsion composition according to the present invention exhibits excellent preservative activity against bacteria and fungi, and in particular, exhibits a synergistic preservative effect against fungi, thereby providing an excellent preservative effect even with a small amount. Due to the above characteristics, the concentration of preservatives used can be reduced.

[0014] This invention establishes a novel preservation system in emulsion formulations by combining a preservation ingredient with a specific emulsifier capable of enhancing preservation power and exhibiting synergistic preservative effects. Consequently, the phenomenon of preservation power inhibition caused by emulsifiers is improved, and excellent preservation effects and emulsion stability can be secured with a minimal amount of preservative. Furthermore, since the enhancement of preservation power is achieved by utilizing an emulsifier, which is an essential ingredient in the manufacture of emulsion formulations, the system can be universally applied to cosmetic compositions. Specific details for implementing the invention

[0015] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by a skilled expert in the art to which the present invention pertains. In general, the nomenclature used herein is well known and commonly used in the art. Furthermore, in describing embodiments of the present invention, detailed descriptions of related known components or functions are omitted if it is determined that such detailed descriptions would hinder understanding of the embodiments of the present invention. Additionally, while embodiments of the present invention will be described below, the technical concept of the present invention is not limited or restricted thereto and can be modified and implemented in various ways by those skilled in the art.

[0016] In this specification, when a part is described as including a certain component, it means that, unless specifically stated otherwise, it does not exclude other components but may include additional components. In this specification, the term "and / or" includes a combination of a plurality of related items or any one of a plurality of related items.

[0018] The present invention establishes a novel preservation system for emulsion formulations by utilizing an emulsifier having emulsion stability to realize preservation effects and preservative synergy effects.

[0019] According to an embodiment of the present invention, an emulsion composition comprising 1,2-heptanediol and an emulsifier is included. The emulsion composition contains a small amount of 1,2-heptanediol as a preservative, and through combination with a specific emulsifier, not only can the preservative efficacy be maintained, but a synergistic preservative effect against fungi can also be achieved. Furthermore, since the preservative component is used in a small amount, it can be safely used on the human body and may cause minimal skin irritation.

[0020] In this specification, the term “synergy effect” refers to an effect achieved when the total cumulative effect resulting from the interaction of two different chemical substances or biological structures is greater than the sum of any individual effects among them. In the present invention, the synergy effect relates to a synergistic antimicrobial effect.

[0021] In the present invention, 1,2-heptanediol, which is a preservative component, is a type of 1,2-alkanediol that is gaining attention as a substitute for preservative components and has a chain of 7 carbon atoms, so it can have excellent preservative power like 1,2-hexanediol.

[0022] In the examples, 1,2-heptanediol may be included in an amount of 0.1 to 1.5 weight% based on the total weight of the emulsion composition, specifically 0.3 to 1.1 weight%, and more specifically 0.5 to 0.7 weight%. When the 1,2-heptanediol is included in an amount of 0.1 to 1.5 weight%, the preservative power is superior and there may be little or no skin irritation.

[0023] In the present invention, the emulsifier can stabilize the preservative component to maintain its preservative efficacy, and in particular, can exhibit high preservative efficacy by providing a synergistic preservative effect against fungi. Furthermore, the emulsifier according to the present invention can exhibit excellent preservation power and a synergistic preservative effect when combined with 1,2-heptanediol, and can improve the phenomenon of reduced preservation power caused by the emulsifier and ensure preservation power and emulsion stability.

[0024] In the examples, the emulsifier may include at least one of glyceryl stearate / PEG-100 stearate and polyglyceryl-3 distearate*glyceryl stearate citrate. Glyceryl stearate / PEG-100 stearate refers to a mixture of glyceryl stearate and PEG-100 stearate, and polyglyceryl-3 distearate*glyceryl stearate citrate refers to a complex based on polyglyceryl-3 distearate and glyceryl stearate citrate.

[0025] In the examples, the emulsifier may be included in an amount of 1.0 to 5.0 weight% based on the total weight of the emulsion composition, specifically 2.0 to 4.5 weight%, and more specifically 3.0 to 4.0 weight%. When the emulsifier is included in an amount of 1.0 to 5.0 weight%, the preservative stability or preservative synergistic effect may be particularly excellent.

[0026] In the examples, 1,2-heptanediol may exhibit better preservation stability or synergistic effects depending on the type and content of the emulsifier.

[0027] In the example, when the emulsifier is glyceryl stearate / PEG-100 stearate, the 1,2-heptanediol may be included in an amount of 0.1 to 1.5 weight% based on the total weight of the emulsion composition, specifically 0.3 to 1.2 weight%, and more specifically 0.4 to 0.9 weight%. Additionally, the glyceryl stearate / PEG-100 stearate may be included in an amount of 1.0 to 3.9 weight% based on the total weight of the emulsion composition, specifically 2.5 to 3.5 weight%, and more specifically 2.75 to 3.25 weight%. When the 1,2-heptanediol and glyceryl stearate / PEG-100 stearate fall within the above ranges, storage stability or synergistic effects may be even better.

[0028] In the example, when the emulsifier is polyglyceryl-3 distearate*glyceryl stearate citrate, the 1,2-heptanediol may be included in an amount of 0.6 to 1.5 weight% based on the total weight of the emulsion composition, specifically 0.65 to 1.2 weight%, and more specifically 0.7 to 0.9 weight%. Additionally, the polyglyceryl-3 distearate*glyceryl stearate citrate may be included in an amount of 1.0 to 5.0 weight% based on the total weight of the emulsion composition, specifically 2.5 to 4.5 weight%, and more specifically 2.75 to 4.25 weight%. When the 1,2-heptanediol and polyglyceryl-3 distearate*glyceryl stearate citrate fall within the above ranges, storage stability or synergistic effects may be even better.

[0029] The emulsion composition of the present invention may have antimicrobial activity against at least one microorganism selected from the group consisting of bacteria and fungi.

[0030] In the examples, the bacteria refer to a representative taxonomic group of prokaryotes, for example, Escherichia coli ( Escherichia coli ), Pseudomonas aeruginosa ( Pseudomonas aeruginosa ), Staphylococcus aureus ( Staphylococcus aureus ), Staphylococcus epidermidis ( Staphylococcus epidermidis ), Klebsiella pneumoniae ( Klebsiella pneumoniae ), Enterobacter cloaca( Enterobacter cloacae ), Enterobacter gergoviae( Enterobacter gergoviae ), Burkholderia Cepacia( Burkholderia cepacia ), Pseudomonas mendocina( Pseudomonas mendocina ), Pseudomonas sturcheri( Pseudomonas stutzeri ) Pseudomonas fluorescens( Pseudomonas fluorescens ), Pseudomonas putida( Pseudomonas putida ), Alkaligenes faecalis( Faecal alkalis ), Oakrobactrum Tritish( Ochrobactrum triticum ), Cochlea rhizophila( Kocuria rhizophila ), Rhizobium radiobacter( Rhizobium radiobacter ), Komomonas aquatic( Comomonas aquatic ), Sphingobium yanoikuyae( Spingobium yanoikuyae ) and Taurella mechenikensis ( Thauera mechernichensis It can be selected from a group consisting of ), but is not limited thereto.

[0031] In the present invention, the term "fungus" is used interchangeably with "mold" and includes both yeast and mold, for example, Candida albicans ( Candida albicans ), Candida tropicalis( Candida tropicalis ), Candida Stellatoidea( Candida stellate ), Candida glabrata( Candida glabrata ), Candida Crusae ( Candida krusei ), Candida güliemondi( Candida guilliermondii ), Candida Viswanati( Candida viswanathii ), Candida lusitaniée ( Candida lusitania ), Yarowia Lipolitika( Yarrowia lipolytica ), Cryptococcus neoformans( Cryptococcus neoformans ), Cryptococcus gati( Cryptococcus gattii ), Rhodotorula Musilaginosa( Rhodotorula mucilaginosa ) and Saccharomices cerevisiae( Saccharomyces cerevisiae Yeast consisting of ); Aspergillus brasiliensis( Aspergillus brasiliensis ), Aspergillus flavus( Aspergillus flavus ), Penicillium Camembertii ( Penicillium camemberti ), Penicillium villiae ( Penicillium bilaiae ), Penicillium chrysogenium ( Penicillium chrysogenum ), Penicillium claviforme( Penicillium claviforme ), Penicillium crustosium ( Penicillium crustose ), Penicillium roqueforti( Penicillium roquefortii ), Penicillium expansum( Penicillium expansum ), Penicillium fuverulum ( Penicillium puberulum ), Penicillium burcositism ( Penicillium verrucosum ) and Penicillium digitatum ( Penicillium digitatum Molds composed of ); may be one or more selected from the group composed of, but are not limited thereto.

[0032] The emulsion composition of the present invention may have an enhanced preservation effect against microorganisms. The microorganisms may include microorganisms belonging to the fungi.

[0034] According to another embodiment of the present invention, a cosmetic composition comprising an emulsion composition is provided.

[0035] In the present invention, the cosmetic composition may be in an emulsion form. For example, it may be formulated into a water-dispersible formulation dispersed in an aqueous phase, an oil-in-water (O / W), water-in-oil (W / O), water-in-oil-in-water (W / O / W), and oil-in-water-in-oil (O / W / O) type emulsion formulation. However, it is not limited thereto, and the cosmetic composition may be prepared in any formulation conventionally manufactured in the technical field to which the present invention belongs.

[0036] The composition may also be provided in various formulations such as solution, suspension, emulsion, solid, gel, oil, powder, paste or foam aerosol, mist, etc.

[0037] The above emulsion composition may be included in an amount of 0.0001 to 50 weight% relative to the total weight of the cosmetic composition.

[0038] According to the embodiments, the cosmetic composition according to the present invention may additionally include ingredients found in general cosmetic compositions in addition to the above ingredients, such as thickeners, dispersants, functional ingredients, ion chelating agents, pH adjusters, antioxidants, alcohols, plant extracts, fragrances, cooling agents, additives, etc. The amount of the above ingredients is not particularly limited and can be easily selected by a person skilled in the art within a range that does not impair the purpose and effect of the present invention.

[0039] The emulsion composition according to the embodiment of the present invention can be applied not only to cosmetic compositions but also to food, pharmaceuticals, etc., and can be applied to various products requiring preservative power against bacteria and fungi.

[0041] In the following, embodiments for further explaining the present invention in more detail are presented, but the present invention is not limited thereto.

[0043] [제조예]

[0044] Preparation of examples 1 to 6

[0045] In order to compare the preservative stability and / or preservative synergy effects according to the type and content of 1,2-heptanediol and emulsifier, examples were prepared with different types and contents of emulsifiers.

[0046] Specifically, Examples 1 to 6 of emulsion formulations were prepared by including one of glyceryl stearate / PEG-100 stearate and polyglyceryl-3 distearate*glyceryl stearate citrate as an emulsifier together with 1,2-heptanediol as shown in Table 1.

[0047]

[0049] The specific manufacturing method is as follows.

[0050] After dispersing a thickening agent in the aqueous phase, the mixture was heated to 78°C. Then, the heated aqueous phase was slowly added while stirring at 3000 rpm to prepare a mixture. The mixture was emulsified by stirring at 6000 rpm for 10 minutes at 78°C using a HOMO MIXER. Afterward, the mixture was cooled to 45°C, 1,2-heptanediol was added, and the mixture was emulsified again by stirring at 45°C and 6000 rpm for 3 minutes. Finally, the emulsified mixture was cooled to 35°C and degassed to complete the example.

[0052] 1 to 12 in comparison

[0053] As shown in Table 2 below, Comparative Examples 1 to 12 of emulsion formulations were prepared by including 1,2-Heptanediol alone or using an emulsifier of a different type than that of the Examples. The units in Table 2 are weight%, and the preparation method is the same as that of the Examples.

[0054]

[0056] [실호예]

[0057] 1. Preservation test (ISO 11930 standard)

[0058] ISO 11930 standards were used to test the preservation efficacy of Examples 1 to 6 and Comparative Examples 1 to 12 above. In this experiment, as a strain E.coli(E. coli; ATCC 8739), S.aureus (Staphylococcus aureus; ATCC 6538), P.aeruginosa (Pseudomonas aeruginosa; ATCC 9027), C. albicans (Candida; ATCC 10231) and A.brasiliensis (Mold; ATCC 16404) was used. The specific experimental method is as follows.

[0059] For 20g of the composition in the examples and comparative examples, 1 * 10 of the inoculated bacterial solution of the strain after removing microorganisms was used per sample. 5 ~1*10 7 The mixture was added and combined to achieve a CFU / g concentration. Samples inoculated with the bacterial suspension were cultured at 22.5°C (±2.5°C) for 4 weeks, and 1g of the composition was obtained at intervals of 7, 14, and 28 days. The obtained samples were neutralized, dispensed into the corresponding media for each bacterial strain, and cultured to verify the results. The culture conditions were as follows: bacteria ( E.coli (C .albicans In the case of ), 2 to 3 days at 32.5℃(±2.5℃), mold ( A.brasiliensis In the case of ), it was set to 3 to 5 days at 22.5℃ (±2.5℃).

[0060] The criteria for evaluating preservation strength tests based on the above standard are as follows.

[0061]

[0063] The colony-forming units (CFU / g) of the examples and comparative examples measured by the above method are shown in Tables 4 to 13 below.

[0064]

[0065]

[0066]

[0067]

[0068]

[0069]

[0070]

[0071]

[0072]

[0073]

[0075] As shown in Tables 4 to 13 above, Examples 1 to 6, prepared by combining 1,2-heptanediol with a specific emulsifier, were confirmed to have excellent storage stability and a synergistic effect on preservation against mold. Specifically, Examples 1 to 6 are E.coli , S.aureus , P.aeruginosa and C. albicans It was confirmed that the excellent preservation power of 1,2-heptanediol was maintained when compared to Comparative Examples 2 and 3, in which no emulsifier was added. A.brasiliensis It was confirmed that the preservation power increased compared to Comparative Examples 2 and 3, in which no emulsifier was added. On the other hand, although emulsifiers were used in Comparative Examples 4 to 12, all A.brasiliensis It did not show a synergistic effect on preservation power, so the preservation power was poor.

[0076] especially, A.brasiliensis In this case, while Comparative Examples 1 to 12 showed test results indicating unsuitable preservation ability according to the ISO 11930 standard, Examples 1 to 6 showed test results indicating suitable preservation ability, thereby proving the synergistic effect. Furthermore, in the case of Comparative Examples 5, 8 to 12 S.aureus It was confirmed that the preservation effect for was inhibited.

[0077] In conclusion, it was confirmed that when 1,2-heptanediol is combined with one of glyceryl stearate / PEG-100 stearate and polyglyceryl-3 dicetate*glyceryl stearate citrate in appropriate amounts, it has excellent preservation stability and / or synergistic preservative effects.

[0079] Accordingly, it was confirmed that the components of 1,2-heptanediol and a specific emulsifier in the emulsion composition of the present invention, and their blending content, are important for maintaining preservation stability and producing a synergistic effect on the preservation power against fungi, thereby exhibiting a sufficient preservation effect with a small amount.

[0081] Foregoing, specific parts of the content of the present invention have been described in detail. It will be apparent to those skilled in the art that such specific descriptions are merely preferred embodiments and do not limit the scope of the present invention. Accordingly, the actual scope of the present invention is defined by the appended claims and their equivalents.

Claims

Claim 1 An emulsion composition having preservative stability or synergistic effects, comprising 1,2-heptanediol and an emulsifier, wherein the emulsifier comprises at least one of polyglyceryl-3 distearate*glyceryl stearate citrate and glyceryl stearate / PEG-100 stearate. Claim 2 delete Claim 3 An emulsion composition according to claim 1, wherein the 1,2-heptanediol is included in an amount of 0.1 to 1.5 weight% based on the total weight of the emulsion composition. Claim 4 An emulsion composition according to claim 1, wherein the emulsifier is included in an amount of 1.0 to 5.0 weight% based on the total weight of the emulsion composition. Claim 5 An emulsion composition according to claim 1, wherein the emulsifier is glyceryl stearate / PEG-100 stearate and is included in an amount of 1.0 to 3.9 weight% based on the total weight of the emulsion composition; and the 1,2-heptanediol is included in an amount of 0.1 to 1.5 weight% based on the total weight of the emulsion composition. Claim 6 An emulsion composition according to claim 1, wherein the emulsifier is polyglyceryl-3 distearate* glyceryl stearate citrate and is included in an amount of 1.0 to 5.0 weight% based on the total weight of the emulsion composition; and the 1,2-heptanediol is included in an amount of 0.6 to 1.5 weight% based on the total weight of the emulsion composition. Claim 7 In claim 1, the emulsion composition is an emulsion composition having antibacterial activity against at least one of bacteria and fungi. Claim 8 In claim 7, the bacteria are Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter gergoviae, Burkholderia cepacia, Pseudomonas mendocina, Pseudomonas stutzeri, Pseudomonas fluorescens, Pseudomonas putida, Alcaligenes faecalis, and Oxrobacterum One or more selected from the group consisting of Ochrobactrum tritici, Kocuria rhizophila, Rhizobium radiobacter, Comomonas aquatic, Spingobium yanoikuyae, and Thaurera mechernichensis, and said fungus is one or more selected from Candida albicans, Candida tropicalis, Candida stellatoidea, Candida glabrata, Candida krusei, Candida guilliermondii, Candida viswanathii, Candida lucitaniae lusitaniae), Yarrowia lipolytica,Cryptococcus neoformans, Cryptococcus gattii, Rhodotorula mucilaginosa, Saccharomyces cerevisiae, Aspergillus brasiliensis, Aspergillus flavus, Penicillium camemberti, Penicillium bilaiae, Penicillium chrysogenum, Penicillium claviforme, Penicillium crustosum, Penicillium roqueforti, Penicillium expansum, An emulsion composition comprising one or more selected from the group consisting of Penicillium puberulum, Penicillium verrucosum, and Penicillium digitatum. Claim 9 In claim 1, the emulsion composition is an emulsion composition having a synergistic preservative effect against fungi. Claim 10 A cosmetic composition comprising an emulsion composition according to any one of claims 1, 3 to 9.

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