Shoes that help ease foot coldness and manage diabetic blood sugar

Abstract

The present invention relates to a shoe that helps manage cold feet and diabetes, and more specifically, to a shoe that regulates the temperature of the foot to alleviate cold feet and simultaneously supports blood sugar management for diabetic patients. The shoe according to the present invention comprises a graphite sheet having a plurality of through holes, a water-dispersible polyurethane resin liquid is coated thereon, a covering is adhered to the upper surface of the sheet, and a polyurethane resin is foamed to adhere the covering to the sheet by wrapping the lower surface of the sheet, and the shoe is characterized in that the inner fabric is Gore-Tex to contact the insole. According to the present invention, an insole is used that is coated with a water-dispersible polyurethane resin liquid containing an aluminum additive on a graphite sheet, and the inner fabric of the shoe that contacts the insole is made of Gore-Tex. In this case, by using a graphite sheet, the temperature of the foot is maintained uniformly to improve blood flow, thereby managing cold feet and diabetic blood sugar, and durability can be increased by being coated with a water-dispersible polyurethane resin liquid. In addition, since the part that contacts the insole is formed of Gore-Tex, moisture wicking and ventilation are improved, thereby maintaining foot health.

Description

Technology Field

[0001] The present invention relates to a shoe that helps manage cold feet and diabetes, and more specifically, to a shoe that regulates the temperature of the foot to alleviate cold feet and simultaneously supports blood sugar management for diabetic patients. Background Technology

[0002] Many people suffer from symptoms of cold feet regardless of age or gender. Symptoms of cold feet are generally a sign of reduced blood flow. Reduced blood flow can be indicated by vascular disease or impaired blood flow regulation. The former occurs more frequently in the elderly, while the latter occurs more frequently in young people. Additionally, the ratio of men to women with cold feet symptoms is 2:3, with Korean women at 25%, Japanese women at 54.3%, and Chinese women at 20%.

[0003] Cold feet can be caused by various factors and are frequently observed, particularly in diabetic patients. Diabetic patients are prone to cold feet due to peripheral neuropathy and blood circulation problems. These symptoms not only cause discomfort in the patient's daily life but, in severe cases, can lead to more serious complications such as ulcers and infections.

[0004] Currently, various products designed to alleviate cold feet exist on the market. For example, heated insoles and heated socks are available; however, these products have drawbacks, such as difficulty in maintaining a consistent temperature and limited customization options. Furthermore, while periodic monitoring is essential for diabetic patients to manage blood sugar levels, a product that addresses both needs simultaneously has not yet been developed. Prior art literature

[0005] Published Utility Model No. 20-2021-0000851 (Publication Date: April 21, 2021) Published Patent No. 10-2021-0103141 (Publication Date: August 23, 2021) Registered Patent No. 10-2016981 (Registration Date: August 27, 2019) Published Patent Re-10-2009-0110805 (Publication Date: October 22, 2009) The problem to be solved

[0006] Previously, there was a problem in that there were no shoes that could alleviate cold feet by inducing a rise in foot temperature and improving blood flow to the feet, as well as help manage blood sugar levels in diabetes.

[0007] The present invention aims to solve the above-mentioned problems. The present invention aims to provide a shoe that not only alleviates cold feet by equalizing the temperature of the wearer's feet and inducing a rise in foot temperature, but also helps in managing blood sugar levels in diabetes. means of solving the problem

[0008] The shoe according to the present invention comprises a graphite sheet having a plurality of through holes, a water-dispersible polyurethane resin liquid is coated thereon, a covering is adhered to the upper surface of the sheet, and a polyurethane resin is foamed to adhere the covering to the sheet by wrapping the lower surface of the sheet, and the shoe is characterized in that the inner fabric is Gore-Tex to contact the insole.

[0009] In addition, regarding the above-mentioned footwear, the water-dispersible polyurethane resin liquid comprises: a stirring step of preparing a first solution by mixing 0.04 moles of polytetramethylene ether glycol (PTMG), 0.08 moles of dimethylolpropionic acid (DMPA), and dibutyltin dilaurate (DBTBL) and stirring at 70 to 90°C; a polymer synthesis step of synthesizing a polymer by adding 0.2112 moles of isophorone diisocyanate (IPDI) and acetone to the first solution and stirring; a polymer neutralization step of neutralizing the polymer by cooling the polymer synthesized in the polymer synthesis step to 30 to 45°C, adding 0.08 moles of triethylamine (TEA), and stirring; and to the polymer neutralized in the polymer neutralization step It is preferable that the product be manufactured by comprising a polyurethane synthesis step of synthesizing a water-dispersible polyurethane (PUD) by adding 0.00425 moles of ethylenediamine (EDA) and 0.05175 moles of metaphenylenediamine (MPD), and a mixing step of mixing 65 to 75 weight% of the water-dispersible polyurethane and 35 to 25 weight% of an aluminum-based additive.

[0010] In addition, in the above-described shoe, it is preferable that the insole is formed by coating the water-dispersible polyurethane resin liquid onto the sheet through an immersion step of immersing the sheet in the water-dispersible polyurethane resin liquid, an air injection step of injecting air onto the sheet after the immersion step so that the through hole is not closed by the water-dispersible polyurethane resin liquid, and a drying step of drying the water-dispersible polyurethane resin liquid after the air injection step.

[0011] In addition, regarding the above-mentioned shoes, it is preferable to add distilled water to the water-dispersible polyurethane synthesized in the polyurethane synthesis step and stir to obtain a solid content of about 40 to 60%, and then mix the water-dispersible polyurethane with the aluminum-based additive in the mixing step. Effects of the invention

[0012] According to the present invention, an insole is used that is coated with a water-dispersible polyurethane resin liquid containing an aluminum additive on a graphite sheet, and the inner fabric of the shoe that contacts the insole is made of Gore-Tex. In this case, by using a graphite sheet, the temperature of the foot is maintained uniformly to improve blood flow, thereby managing cold feet and diabetic blood sugar, and durability can be increased by being coated with a water-dispersible polyurethane resin liquid. In addition, since the part that contacts the insole is formed of Gore-Tex, moisture wicking and ventilation are improved, thereby maintaining foot health. Brief explanation of the drawing

[0013] FIG. 1 is a conceptual diagram of one embodiment of a shoe according to the present invention, FIG. 2 is a conceptual diagram of the coating step of an insole applied to the embodiment of FIG. 1, FIG. 3 is a conceptual diagram for making a moisture-removing polyurethane resin liquid applied to the embodiment of FIG. 1. FIG. 4 is a conceptual diagram of the manufacturing process of an insole applied to the embodiment of FIG. 1, Figure 5 is a sample photograph for testing a water-dispersible polyurethane resin liquid, Figure 6 is a photograph of the results of testing bending durability using the sample of Figure 5. Figure 7 is a surface photograph of the OR sample in Figure 6, Figure 8 is a surface photograph of the HT-1 sample in Figure 6, Fig. 9 is a surface photograph of the HT-2 sample in Fig. 6, Fig. 10 is a surface photograph of HT-3 in Fig. 6, Fig. 11 is a tensile analysis graph of the sample of Fig. 5, Figure 12 is a photograph of the location for performing a thermal conductivity test using the sample of Figure 5, Figure 13 is a thermal conductivity test graph of the OR sample, Figure 14 is a graph of the thermal conductivity test of the HT-1 sample, Figure 15 is a graph of the thermal conductivity test of the HT-2 sample, Figure 16 is a thermal conductivity test graph of the HT-3 sample, FIG. 17 shows the results of foot temperature change when wearing the insole of the present embodiment and a standard insole, FIG. 18 shows a comparison of foot temperatures when wearing the insole of the present embodiment and a standard insole. FIG. 19 shows the results of changes in lower limb blood flow velocity when wearing the insole of the present embodiment and a standard insole (right: graphite insole, left: standard insole), Figure 20 shows a comparison of lower limb blood flow velocities according to foot conditions. Fig. 21 is a photograph of the foot sensory perception assessment measurement, Figure 22 shows the results of the foot sensory perception evaluation. Specific details for implementing the invention

[0014] An embodiment of a shoe according to the present invention will be described with reference to FIGS. 1 to 22.

[0015] The shoe (1) according to the present invention includes an insole (5), and an inner fabric (3) is formed of Gore-Tex to come into contact with the insole (5).

[0016] Here, the insole is formed by coating a water-dispersible polyurethane resin liquid onto a graphite sheet having multiple through holes, then adhering a coating to the upper surface of the sheet, and then foaming the polyurethane resin to wrap around the lower surface of the sheet so that the coating adheres to the sheet.

[0017] To describe the process of making the insole (5) in more detail, first, a first sheet (10) made of graphite is formed. The graphite sheet is formed into the shape of an insole, and a plurality of through holes (11) are perforated in the graphite sheet to create the first sheet (10). If blood does not circulate smoothly in the hands or feet, cold air is generated at the extremities of the hands or feet. Also, the temperature distribution of the feet is not uniform, and the temperature decreases as it goes toward the extremities. Graphite has a high heat transfer rate. Therefore, when a graphite sheet is used in an insole, heat is transferred through the insole when the foot comes into contact with the insole, so the temperature of the foot can be made uniform throughout.

[0018] Then, the first sheet (10) is coated with a water-dispersible polyurethane (PUD) resin solution. To explain the coating process in detail, the coating process includes an immersion step (S21), an air dispersion step (S23), and a drying step (S25).

[0019] The immersion step (S21) immerses the first sheet (10) in a water-dispersible polyurethane resin solution. When the first sheet (10) is immersed in the water-dispersible polyurethane resin solution, the through hole (11) of the first sheet (10) may be blocked by the water-dispersible polyurethane resin solution.

[0020] The air injection step (S23) injects air into the first sheet (10) after the immersion step (S21) so that the through hole (11) is not blocked by the water-dispersible polyurethane resin liquid. Air is injected into the through hole (11) to prevent it from becoming blocked.

[0021] The drying step (S25) dries the water-dispersible polyurethane resin liquid after the air spraying step (S23). It is dried at a temperature of 180°C for approximately 10 minutes.

[0022] After the water-dispersible polyurethane resin liquid is coated on the first sheet (10), a coating (30) is adhered to the upper surface of the first sheet (10). To do this, an adhesive is applied to the upper surface of the first sheet (10), and then the coating (30) is adhered to the first sheet (10).

[0023] Then, a polyurethane resin (40) is foamed to wrap around the lower surface of the first sheet (10) and bond it to the covering (30) so as to protect the first sheet (10) and absorb shock during walking. Then, the polyurethane resin (40) is not only adhered to the covering (30) through the through hole (11) but also wraps around the first sheet (10) and adheres to the covering (30).

[0024] In this embodiment, the water-dispersible polyurethane resin liquid used to coat the first sheet (10) serves to reduce the bonding of graphite and also increase the durability of the first sheet (10). To this end, the water-dispersible polyurethane resin liquid used for coating is prepared through a stirring step (S51), a polymer synthesis step (S53), a polymer polymerization step (S55), a polyurethane synthesis step (S57), and a mixing step (S59).

[0025] In the stirring step (S51), 0.04 moles of polytetramethylene ether glycol (PTMG), 0.08 moles of dimethylolpropionic acid (DMPA), and dibutyltin dilaurate (DBTBL) are mixed in a 3-neck flask equipped with a stirrer, a reflux condenser, and a nitrogen inlet, and stirred at 70 to 90°C to prepare a first solution. Preferably, the mixture is stirred at 150 rpm for 1 hour at 80°C. In this example, 3 to 4 drops of DBTBL were added.

[0026] In the polymer synthesis step (S53), 0.2112 moles of isophorone diisocyanate (IPDI) and acetone are added to the first solution, and then stirred to synthesize the polymer. Acetone is added to control viscosity. Thus, viscosity is controlled according to the amount of acetone injected, and in this embodiment, 10 to 20 ml of acetone was injected. It is also preferable to stir for about 1 hour. Then, the NCO groups of IPDI and the OH groups of PTMG react uniformly, and through this, a prepolymer containing -NCO ends is synthesized.

[0027] The polymer neutralization step (S55) involves cooling the polymer (Prepolymer) synthesized in the polymer synthesis step (S53) to 30 to 45°C, adding 0.08 moles of triethylamine (TEA), and stirring to neutralize the polymer (Prepolymer). In this embodiment, the reactor was cooled to 40°C, and then TEA with the same molar amount as DMPA was added and stirred at 150 rpm for 1 hour to neutralize the Prepolymer.

[0028] In the polyurethane synthesis step (S57), 0.00425 moles of ethylenediamine (EDA) and 0.05175 moles of metaphenylenediamine (MPD) are added to the polymer neutralized in the polymer neutralization step (S55) to synthesize a water-dispersible polyurethane (PUD). Then, distilled water is added and stirred to achieve a solid content of approximately 40 to 60%. In the case of this example, distilled water was added to achieve a solid content of approximately 50%, and the mixture was stirred at 400 rpm for 1 hour.

[0029] The mixing step (S59) involves mixing 65 to 75 weight% of water-dispersible polyurethane and 35 to 25 weight% of aluminum-based additives. In this embodiment, the mixture was mixed to have 70 weight% water-dispersible polyurethane and 30 weight% aluminum-based additives and stirred for 30 minutes.

[0030] Since the first sheet (10) is formed of graphite, if it is used for a long time, powder is generated, and a bonding phenomenon occurs in which the powder seeps out onto the surface of the coating (30). The water-dispersible polyurethane resin liquid increases the bending durability and friction fastness of the graphite. Therefore, in the case of this embodiment, the water-dispersible polyurethane resin liquid can wrap around the first sheet (10) to prevent the bonding phenomenon. At this time, if a through hole (11) is formed in the first sheet (10) after coating the first sheet (10) with the water-dispersible polyurethane resin liquid, the inner surface of the through hole (11) is not coated with the water-dispersible polyurethane resin liquid, so powder is generated on the inner surface of the through hole (11), and a bonding phenomenon may occur. However, in the case of this embodiment, since the coating step (S20) is performed after forming the through hole (11) in the first sheet (10), the water-dispersible polyurethane resin liquid is coated on the inner surface of the through hole (11). Therefore, the occurrence of joint phenomena can be prevented.

[0031] Meanwhile, in the case of this embodiment, an aluminum-based additive was added to the water-dispersible polyurethane resin liquid. To determine the effect of adding the aluminum additive, flexural durability, tensile strength and elongation analysis, and thermal conductivity analysis tests were performed for four cases as shown in Table 1 below.

[0033] classification Impregnation resin (WT%) OR HT-1 HT-2 HT-3 Mixing ratio water-dispersible polyurethane 100 70 50 30 aluminum-based additives 0 30 50 70

[0034] Flexural durability, tensile strength, and elongation analysis tests were performed using a sample as shown in Fig. 5. The flexural durability test is designed to analyze flexibility and durability. The sample was prepared by cutting it into a uniform size and fixing it to a bending tester. The analysis was then conducted by setting the number of cycles, temperature, and speed according to the conditions to be analyzed. The measurement conditions were 10,000 cycles. Measurements were taken at room temperature at a bending angle of 90°.

[0035] The results of the flexural durability are shown in Figures 6 to 10. Looking at Figures 9 and 10, surface cracking was observed in samples HT-2 and HT-3 after 10,000 flexural tests, which confirms that the flexibility of HT-2 and HT-3 was significantly reduced compared to the OR samples.

[0036] The results of the analysis of tensile strength and elongation are shown in [Table 2] and Figure 11. It can be seen that as the proportion of aluminum-based additives increases, tensile strength increases but elongation decreases. However, in the sample with 30 WT% aluminum-based additives, elongation actually improves slightly.

[0038] classification Tensile strength (MPa) Elongation at break(%) OR 1.45. 461.6 HT-1 1.47 505.1 HT-2 1.49 430.0 HT-3 1.79 4.5

[0039] As shown in Fig. 12, a temperature sensor was attached according to the location of the sample, and the sample was placed on a hot plate at 50°C to analyze the thermal conductivity by observing the temperature change over time. The measurement conditions were 50°C for 10 minutes, and the measurement results are as shown in Figs. 13 to 16 and [Table 3] below.

[0040] It can be seen that the sample with the shortest time to reach the maximum temperature is HT-2. In the case of sample HT-3, which has the highest proportion of aluminum-based additives, the time to reach the maximum temperature was delayed, but the maximum temperature was the highest.

[0041] Through the above tests, it can be seen that the flexibility and thermal conductivity of the water-dispersible polyurethane resin film vary depending on the ratio of aluminum-based additives. In this case, as the ratio of aluminum-based additives increases, the flexibility of the film decreases and surface cracking occurs, but flexibility does not become an issue up to a maximum of 30 WT%.

[0042] And in the tensile strength analysis, it can be seen that the 30 WT% sample exhibits the highest elongation (505%).

[0044] classification Minimum temperature (°C) Maximum temperature (°C) Time to reach maximum temperature (s) OR T1 25.6 40.7 300 T2 27.2 45.3 210 T3 28.5 40.5 285.6 average 27.1 42.2 265.2 HT-1 T1 27.0 43.4 231.6 T2 27.9 46.9 94.2 T3 28.4 44.0 285.6 average 27.8 44.8 203.8 HT-2 T1 27.2 44.8 205.62 T2 26.9 47.2 76.2 T3 28.1 42.9 246 average 27.4 45.0 175.9 HT-3 T1 27.8 43.6 336 T2 27.9 47.1 246 T3 28.0 45.6 349.02 average 27.9 45.4 310

[0045] In the case of thermal conductivity, it increased as the proportion of aluminum-based additives increased, but it was found to decrease at 70 WT%. Also, it was found that the thermal conductivity was relatively higher in the 30 WT% sample.

[0046] Therefore, it can be seen that the thermal conductivity increases as the proportion of aluminum-based additives increases, but for insole durability, the sample with a ratio of 30 WT% is the most suitable ratio as it does not cause cracking and has a higher thermal conductivity than the existing water-dispersible polyurethane resin liquid.

[0047] Therefore, it can be seen that when a graphite sheet is coated using a water-dispersible polyurethane resin liquid mixed with an aluminum additive as in this embodiment, not only can the joint phenomenon be prevented, but the durability of the insole (5) can also be increased.

[0048] In addition, a test was conducted to examine changes in foot temperature and lower limb blood flow velocity according to the insole (5) of this embodiment. To this end, after performing cold stress considering symptoms of cold feet, changes in foot temperature after wearing a general insole and the insole of this embodiment were analyzed through thermal imaging, and changes in lower limb blood flow velocity were analyzed by measuring the blood flow velocity during contraction of the tibial artery of the lower limb using ultrasonic Doppler.

[0049] FIGS. 17, FIGS. 18 and Table 4 are the foot temperature results when wearing the insole (5) of this embodiment and a standard insole.

[0050] Mean ± SD Standard insoles (unit ℃) Graphite Insoles (Unit: ℃) Hallux 26.7±4.9 27.9±4.4 Toes 26.1±4.7 27.9±4.3 Metatarsals 27.0±3.8 28.3±3.7 Medial(Arch) 28.4±3.1 29.5±3.3 Lateral 27.6±3.2 28.9±3.3 Heel 26.8±3.3 28.3±3.2 Foot average 27.4±3.5 28.7±3.5

[0052] Test results show that when wearing a graphite insole (the insole of this embodiment), the average foot temperature is 1.3℃ higher compared to wearing a standard insole.

[0053] In this experiment, to analyze changes in foot temperature when wearing graphite insoles and standard insoles, FLIR Research software was used to divide the foot into seven anatomical zones (①hallux; ②toes; ③metatarsal; ④medial(arch); ⑤lateral; ⑥heel; ⑦foot average). In the analysis of foot temperature changes under cold-stress conditions and according to insole type, a significant increase in temperature was observed in all anatomical zones of the foot after wearing graphite insoles. Furthermore, the toes zone, the distal part of the foot, showed a temperature 1.8°C higher when wearing graphite insoles. Conversely, the medial(arch) zone showed the lowest temperature change with a 1.1°C increase when wearing graphite insoles. Additionally, the distal part of the foot, which is relatively more affected by body temperature, showed a greater increase in temperature. It is believed that the body heat transferred from the lower extremities to the proximal part of the foot was rapidly transferred to the distal part due to the high thermal conductivity of graphite, resulting in an effective isothermal effect to the distal part of the foot.

[0054] And FIGS. 19, FIGS. 20 and Table 5 are the results of the change in lower limb blood flow velocity when wearing the insole (5) of this embodiment and a standard insole. The unit of Table 5 is mm / s.

[0055] n = 20 General insoles Graphite insole Posterior tibial artery (lower limb) 512.5±149.1 562.4±162.3 Brachial artery (Upper limb) 515.3±183.4 548.6±154.1

[0057] When wearing graphite insoles, the blood flow velocity in the upper and lower extremities increased by 49.9 mm / s in the posterior tibial artery and 33.3 mm / s in the brachial artery.

[0058] To analyze changes in lower extremity blood flow velocity when subjects wore graphite insoles and general insoles, the blood flow velocity during contraction of the tibial artery of the lower extremity was measured using an ultrasound Doppler (SonoAce6000, Samsung Medison Ltd., Korea), and after calculating the mean ± standard deviation, a paired t-test was performed.

[0059] In the results of changes in lower extremity blood flow velocity, wearing graphite insoles (562.4±162.3mm / s) showed a blood flow velocity approximately 10% (49.9mm / s) faster than wearing regular insoles (512.5±149.1mm / s).

[0060] In the case of upper extremity blood flow velocity, wearing graphite insoles (548.6±154.1) showed a blood flow velocity approximately 7% (33.3 mm / s) faster than wearing regular insoles (515.3±183.4).

[0061] Considering that wearing graphite insoles results in a higher foot temperature than wearing regular insoles, it is determined that the increase in foot temperature induces an increase in blood flow velocity.

[0062] Figures 21, 22, and Table 6 show the degree of improvement in foot sensation perception evaluation.

[0064] n = 20 General insoles Graphite insole Hallux 7.1±1.1 6.4±0.9 2 nd -3 rd metatarsal 7.4±0.7 6.4±0.9 Mid-foot 6.9±1.2 6.5±1.4 Heel 6.8±1.0 6.4±0.9

[0066] It was found that the foot sensation perception score decreased when wearing graphite insoles compared to regular insoles, which is believed to be due to improved foot sensation as foot temperature and blood flow velocity increased.

[0067] In this embodiment, the results of the sensory perception evaluation of the subject's right foot according to foot conditions were analyzed using a two-point discriminator. After performing foot cold stress and wearing standard insoles, the foot sensory perception scores showed generally high scores, with an overall zone average of 7 points or higher. In contrast, after wearing graphite insoles, the average score was lower at 6.4 points compared to cold stress and standard insoles. 2 nd -3 rd In the metatarsal zone, the foot sensory perception assessment score is statistically significantly lower when wearing graphite insoles (6.4±0.9) compared to standard insoles (7.4±0.7). Hallux, 2 corresponding to the distal part of the foot. nd -3 rd The foot sensory perception assessment score decreased significantly in the metatarsal zone. In the mid-foot zone, where foot temperature changes were relatively small, there was no significant difference in the sensory perception assessment scores. Additionally, it is believed that the heel zone did not show a difference because the degree of sensation was not sensitive due to skin keratinization.

[0068] Meanwhile, the effects of using the shoes of this embodiment on blood glucose, pancreatic function, and insulin resistance in patients with type 2 diabetes were confirmed. The difference before and after wearing the insoles was compared by measuring fasting blood glucose and collecting blood samples from subjects visiting the hospital. In Table 7 below, the first test is the result before the subject wore the shoes, the second test is the result 3 months after the first test and wearing the shoes, and the third test is the result 3 months after the second test when the insoles were continuously worn.

[0070] Inspection cycle Fasting blood sugar (mg / dl) Glycated hemoglobin (HbA1c,%) Blood insulin ((μU / ml) blood C-peptide (ng / ml) HOMA%β HOMA-IR 1st examination 145.56 7.12 8.88 2.04 56.68 1.71 2nd examination 136.64 6.89 8.55 1.90 59.73 1.63 3rd examination 134.92 6.82 8.43 1.98 65.31 1.66

[0072] The test results showed that fasting blood glucose levels tended to decrease from an average of 144 at the start of the study to 137 at the third month, and glycated hemoglobin (HbA1c), which represents the average blood glucose level over three months, showed a significant decrease from an average of 7.1% at the start of the study to 6.6% at the third month. Additionally, blood insulin levels showed a slight decrease from an average of 8.7 at the start of the study to 8.55 at the third month. Furthermore, blood C-peptides, which are breakdown products of insulin and have almost the same meaning, showed a decrease from 2.01 at the start of the study to 1.9 at the third month. Based on the observed decrease in blood glucose levels, the aforementioned decreases in insulin and C-peptides may indicate a reduction in insulin resistance, a significant pathophysiological characteristic of diabetes.

[0073] HOMA-beta, which indicates the pancreas's ability to secrete insulin, showed a slight increase from an average of 56.9 at the start of the study to 59.7 at the third month, suggesting the possibility that pancreatic beta-cell function has improved. HOMA-IR, which indicates the body's insulin resistance, showed a decreasing trend from an average of 1.68 at the start of the study to an average of 1.63 at the third month, suggesting the possibility that insulin resistance, an important pathophysiology of diabetes, has been alleviated.

[0074] Therefore, it can be seen that wearing the insoles for three months likely reduced blood glucose levels, improved pancreatic beta-cell function, and alleviated insulin resistance in diabetic patients. Although not all of these indicators met the significance level in the statistical analysis, the fact that all indicators showed a consistent tendency to move in one direction suggests that the shoes of this embodiment this It can be seen as strongly suggesting the possibility of having an effect that alleviates diabetes.

[0075] For reference, HbA1c is a blood test that indicates the average level of blood sugar control over the past 2 to 3 months. Since meal status has no effect on the results, it is widely used in clinical practice as the most common test to assess the degree of diabetes control. In Korea, the target for diabetes treatment is 6.5% or less, while the American Diabetes Association sets a treatment target of 7.0% or less. For normal individuals without diabetes, the target is 5.7% or less.

[0076] Blood insulin is a very important hormone secreted by the beta cells of the pancreas that is involved in controlling not only the body's glucose metabolism but also the entire energy metabolic process. If insulin secretion decreases abnormally, diabetes may develop. As time passes after the onset of diabetes, the body's ability to secrete insulin gradually declines; in such cases, it becomes more common to use insulin injections rather than oral medication.

[0077] Blood C-peptide is a small protein that is secreted along with insulin when the pancreas produces and secretes insulin. Although it is always secreted in an amount equal to that of insulin, it does not have the same high metabolic activity as insulin, so it maintains a stable concentration in the blood for a considerable period. Clinically, it holds almost the same significance as blood insulin and is commonly used to supplement fluctuating insulin levels.

[0078] And HOMA (Homeostasis Model Assessment) is These indicators were developed by a team at the University of Oxford in the UK. While the insulin secretion capacity of the pancreas can be estimated to some extent through blood insulin or C-peptide levels, accurate interpretation requires correlation with blood glucose levels at the time of measurement; therefore, values ​​are calculated using fasting blood glucose levels and blood insulin or C-peptide levels. HOMA%β is an indicator that assesses pancreatic insulin secretion capacity, while HOMA-IR (insulin resistance) is an indicator that assesses the body's insulin resistance. As one of the credible clinical indicators, it is widely used in epidemiological medical research worldwide.

[0079] And insulin resistance silver The primary pathophysiology of adult-onset diabetes, or Type 2 diabetes, which primarily affects adults, is explained by two factors: insulin resistance, where insulin secreted within the body fails to function properly, and a defect in insulin secretion that prevents the body from overcoming this resistance. When a person becomes obese, mast cells in the abdomen release many harmful substances into the bloodstream; these substances interfere with the proper functioning of insulin secreted by the pancreas. Consequently, blood sugar is not properly processed, which can lead to the development of diabetes. This state in which insulin fails to function properly is called insulin resistance.

[0080] Meanwhile, in this embodiment, the insole (5) is made using graphite with high thermal conductivity, and the inner fabric (3) of the shoe (1) is formed of Gore-Tex. Because Gore-Tex is used, moisture inside the shoe can be expelled to the outside and ventilation with the outside can be facilitated. Explanation of the symbols

[0081] 1 : Shoes 3 : Interior fabric 5 : Insole 10 : 1st sheet 11 : Through hole 20 : Coating liquid 30 : Coating 40 : Polyurethane resin

Claims

Claim 1 The invention comprises an insole formed by foaming a polyurethane resin so that a water-dispersible polyurethane resin liquid is coated onto a graphite sheet having a plurality of through holes, a covering is adhered to the upper surface of the sheet, and the covering is adhered to the sheet by wrapping the lower surface of the sheet, wherein an inner fabric is formed of Gore-Tex to contact the insole, and the water-dispersible polyurethane resin liquid comprises a stirring step of preparing a first solution by mixing 0.04 moles of polytetramethylene ether glycol (PTMG), 0.08 moles of dimethylolpropionic acid (DMPA), and dibutyltin dilaurate (DBTBL) and stirring at 70 to 90°C, a polymer synthesis step of synthesizing a polymer by adding 0.2112 moles of isophorone diisocyanate (IPDI) and acetone to the first solution and stirring, and the A shoe characterized by being manufactured by comprising: a polymer neutralization step in which a polymer synthesized in a polymer synthesis step is cooled to 30 to 45°C, 0.08 moles of triethylamine (TEA) are added, and the polymer is neutralized by stirring; a polyurethane synthesis step in which 0.00425 moles of ethylenediamine (EDA) and 0.05175 moles of m-phenylenediamine (MPD) are added to the polymer neutralized in the polymer neutralization step to synthesize a water-dispersible polyurethane (PUD); and a mixing step in which distilled water is added to the water-dispersible polyurethane synthesized in the polyurethane synthesis step and stirred to obtain a solid content of approximately 40 to 60%, and then 65 to 75 weight% of the water-dispersible polyurethane is mixed with 35 to 25 weight% of an aluminum-based additive. Claim 2 A shoe according to claim 1, wherein the insole is formed by coating the water-dispersible polyurethane resin liquid onto the sheet through an immersion step of immersing the sheet in the water-dispersible polyurethane resin liquid, an air injection step of injecting air onto the sheet after the immersion step so that the through hole is not closed by the water-dispersible polyurethane resin liquid, and a drying step of drying the water-dispersible polyurethane resin liquid after the air injection step. Claim 3 delete Claim 4 delete

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