Liquid transfer device with valve

Abstract

A liquid delivery device is described. The liquid delivery device includes an IV spike configured to be connected to an injection liquid container; a compressible vial adapter configured to be mounted on a vial; an IV port configured to be connected to an injection set; and a valve movable between a first state and a second state upon compressing of the vial adapter. The valve is configured to prevent fluid communication between the IV spike, the vial adapter, and the IV port in the first state, and the valve is configured to provide fluid communication between the IV spike and the vial adapter, and fluid communication between the IV spike and the IV port in the second state.

Description

Background Technology

[0001] The present disclosure generally relates to a liquid delivery device.

[0002] Conventional infusion fluid containers containing infusion fluids to be delivered to a patient generally take the form of infusion fluid bags (or infusion fluid containers), infusion fluid bottles, etc. Pre-filled syringes or vials are typically used to form diluted medicinal infusion fluids by adding a high concentration of drug to the infusion fluid contents via a liquid delivery device. Subsequently, an infusion set including an IV spike can be inserted into the IV port of the liquid delivery device to administer the medicinal infusion fluid contents to a patient. Minimizing the risk to patients receiving a portion of a drug in a highly concentrated, undiluted form is important for patient safety. The present disclosure provides an improved liquid delivery device for administering diluted medicinal infusion fluid contents to a patient.

[0003] According to a first embodiment, the liquid delivery device comprises an IV spike configured to be connected to an injection liquid container upon compaction of the vial adapter, a compactable vial adapter configured to be mounted on the vial, an IV port configured to be connected to an injection set, and a valve movable between a first state and a second state. The valve is preferably configured to prevent fluid communication between the IV spike, the vial adapter, and the IV port in the first state, and to provide fluid communication between the IV spike and the vial adapter, and fluid communication between the IV spike and the IV port in the second state.

[0004] In one embodiment, the IV spike of the liquid delivery device may include a first IV spike lumen and a second IV spike lumen configured to provide fluid communication with an injection liquid container.

[0005] In another embodiment, the valve of the liquid delivery device may be configured to provide fluid communication between the first IV spike lumen and the vial adapter and between the second IV spike lumen and the IV port in a second state.

[0006] In another embodiment, the valve of the liquid delivery device may include a first lumen configured to provide fluid communication between a first IV spike lumen and a vial adapter, and a second lumen configured to provide fluid communication between a second IV spike lumen and an IV port.

[0007] In another embodiment, the vial adapter of the liquid delivery device may include a vial spike for perforating the vial stopper of the vial to provide fluid communication with the vial.

[0008] In another embodiment, the vial adapter of the liquid delivery device comprises an outer vial adapter body and an inner vial adapter body configured to be mounted on a vial, and the inner vial adapter body is configured to slide within the outer vial adapter body when the vial adapter undergoes consolidation from an unconsolidated state to a consolidated state.

[0009] In another embodiment, the vial spike of the liquid delivery device may be configured to puncture the vial stopper when the vial adapter undergoes consolidation.

[0010] In another embodiment, the liquid delivery device may further include a valve actuator movable between a first position and a second position, and the valve actuator is configured to move from the first position to the second position upon consolidation of the vial adapter.

[0011] In another embodiment, the valve actuator of the liquid delivery device may be configured to drive the valve from a first state when the valve actuator is in a first position to a second state when the valve actuator is in a second position during compression of the vial adapter.

[0012] In another embodiment, the valve of the liquid delivery device may include an oblique surface configured to engage with a valve actuator.

[0013] In another embodiment, the liquid delivery device may further include a safety stop configured to prevent the compression of the vial adapter in an uncompressed state.

[0014] In another embodiment, the liquid delivery device further comprises a connector body having an IV spike, a vial adapter, and an IV port coupled thereto, and the valve is movable within the connector body between a first state and a second state.

[0015] In another embodiment, the liquid delivery device further comprises a bore, and the valve further comprises a locking projection, the locking projection being configured to engage with the bore to prevent movement of the valve between a first state and a second state in a pre-compacted state, and the locking projection being configured to be deflected and disengaged from the bore so that the valve can move between a first state and a second state in a compacted state.

[0016] These and other aspects of the liquid delivery device disclosed in this specification will become apparent from the following description. Brief explanation of the drawing

[0017] The present disclosure can be understood by referring to the description of the embodiments presented below together with the accompanying drawings: FIG. 1 illustrates a liquid delivery device according to one embodiment of the present invention combined with an injection liquid container, a vial, and an injection set. Figure 2 shows an exploded view of the liquid delivery device and vial illustrated in Figure 1. FIG. 3 shows a perspective view of a liquid delivery device in a pre-compacted state, a vial shown in FIG. 1, and a pincer-type hand tool for releasing an unperforated vial from the vial adapter of the liquid delivery device. FIG. 4 shows a side view of a liquid delivery device in a pre-compacted state, a vial exemplified in FIG. 1, and a pincer-type hand tool for releasing an unperforated vial from a vial adapter. FIG. 5 shows a measuring plane of the valve (Fig. 5a), a side view of the valve shown in FIG. 2 (Fig. 5b), a bottom view of the valve (Fig. 5c), and a cross-sectional view of the valve shown in FIG. 2 (Fig. 5d). Figure 6 shows a cross-sectional view of a liquid delivery device in a pre-compacted state. Figure 7 shows a cross-sectional view of a liquid delivery device in a compacted state. FIG. 8 shows a cross-sectional view of a liquid delivery device in a pre-compacted state (Fig. 8a) and a cross-sectional view of a liquid delivery device in a compacted state (Fig. 8b). FIG. 9 is a side view of a liquid delivery device including a releaseable safety stop before mounting the liquid delivery device onto the vial shown in FIG. 1. FIG. 10 shows a cross-sectional view of a liquid delivery device including a releaseable safety stop before mounting the liquid delivery device onto the vial shown in FIG. 1. FIG. 11 shows a side view of a pre-compacted liquid delivery device including a releaseable safety stopper and a vial as illustrated in FIG. 1. FIG. 12 shows a side view of a liquid delivery device showing the removal of a releaseable safety stopper and the consolidation of a vial adapter. Specific details for implementing the invention

[0018] FIG. 1 illustrates a liquid delivery device (110) according to a first embodiment of the present invention. As illustrated in FIG. 1, the liquid delivery device (110) is intended for use with an infusion liquid container (102) or an infusion liquid bag, and an infusion set (114). As should be understood by those skilled in the art, the infusion liquid container (102) comprises a reservoir (106) containing an infusion liquid that is fluidly connected to an intravenous administration port (108) and an additive port (104). The liquid delivery device (110) of the illustrated embodiment is also intended for use with an additive delivery device in the form of a sealed vial (112). The vial (112) generally contains a highly concentrated medicinal liquid additive or a lyophilized powder drug that requires reconstitution before administration to a patient, that is, to form a medicinal infusion liquid to be administered to a patient by requiring mixing with the infusion liquid of the infusion liquid container (102). Accordingly, the contents of the vial (112) are introduced into the injection liquid container (102) through the liquid delivery device (110).

[0019] FIG. 2 illustrates a vial (112) having a tubular vial crown (268) having a vial stopper (270) for completely sealing the vial (112). The vial (112) contains a drug (not shown in FIG. 2) to be introduced into an infusion liquid to form a medicinal infusion liquid.

[0020] The liquid delivery device (110) includes a connector body (204). In this embodiment, the connector body (204) has a first branch phase flow control body (206), a second branch phase IV port holder (212), and a third branch phase IV spike (202). The liquid delivery device (110) includes a vial adapter (218) mounted on the flow control body (206).

[0021] The flow control body (206) includes a flow control lumen (1006) (see FIG. 10), a bore (608) (see FIG. 6), a valve actuator bore (610) (see FIG. 6), a valve (272), and a valve cavity (604) (see FIG. 6). As shown in FIG. 6 and FIG. 7, the valve (272) is movably received inside the valve cavity (604). The flow control body (206) is terminated at the vial adapter flange (208) to be mounted on the vial adapter (218). The valve actuator bore (610) extends from the valve cavity (604) to the vial adapter flange (208).

[0022] The IV port holder (212) is configured to receive the IV spike (202) of the infusion set (114) for the purpose of administration. The IV port (214), sealed by a twist-off cap comprising a proximal section (216a) and a distal section (216b), is attached to the IV port holder (212). The IV port (214) includes a diaphragm (1002) (see FIG. 10) that is sealed before being punctured upon insertion of the IV spike (202) of the infusion set (114). As shown in FIG. 12, the distal section (216b) is twisted and broken from the proximal section (216a) to expose the diaphragm (1002) for puncture by the spike (1202) of the infusion set (114) (see FIG. 12). As illustrated in FIG. 6, the IV port holder (212) has an IV port holder lumen (606) that is fluidly in communication with the valve cavity (604) and the valve (272) accordingly.

[0023] The IV spike (202) enables the use of a liquid delivery device (110) having an infusion liquid container (102), that is, for sealingly inserting the IV spike (202) into the intravenous administration port (108) of the infusion liquid container (102). The IV spike (202) is oriented in common with the IV port holder (212). As illustrated in FIG. 10, the IV spike (202) includes a first IV spike lumen (602) and a second IV spike lumen (1010) configured to provide two distinct fluid communication paths between the infusion liquid container (102) and the valve cavity (604) and the valve (272) accordingly. In the illustrated configuration, the first IV spike lumen (602) and the second IV spike lumen (1010) extend generally parallel to each other.

[0024] FIG. 2 also illustrates a vial adapter (218). The vial adapter (218) comprises an inner vial adapter body (244) and an outer vial adapter body (220) and is intended to undergo consolidation from an initial pre-consolidated state (or unconsolidated state) to a final consolidated state (or consolidated state) in which the outer vial adapter body (220) slides to receive the inner vial adapter body (244) inside. The vial adapter (218) includes a vial spike (242) for perforating the vial stopper (270) of the vial (112) in the consolidated state of the vial adapter (218). The vial spike (242) is protected by a thin sheath (264) to maintain sterility until use of the liquid delivery device (110) for administering the medicinal infusion liquid.

[0025] The internal vial adapter body (244) has an inverted cup shape including an upper internal vial adapter wall (260) and a vial crown sleeve (266). The internal vial adapter body (244) is bounded by an internal cavity for receiving a vial crown (268). The upper internal vial adapter wall (260) includes a central aperture (262).

[0026] The vial crown sleeve (266) includes a first pair of longitudinal slits (252a, 252b) and a second pair of longitudinal slits (not shown in FIG. 2) to correspondingly form a pair of diameters of the vial crown retaining members (254a, 254b). The upper inner vial adapter wall (260) preferably has a pair of diameters of cutouts (250a, 250b) radially inward of the vial crown retaining members (254a, 254b) so that the vial crown retaining members (254a, 254b) can pivot relative to the vial crown sleeve (266).

[0027] The vial crown retaining members (254a, 254b) each include a proximal vial crown retaining member (248a, 248b) and a distal vial crown retaining member (256a, 256b). The distal vial crown retaining member (256a, 256b) protrudes radially inward to snap-fit ​​under the vial crown (268) when the inner vial adapter body (244) is mounted on the vial (112). The application of a pincer-type constriction on the proximal vial crown retaining member (248a, 248b) pivots the vial crown retaining member (254a, 254b) relative to the vial crown sleeve (266) and moves the distal vial crown retaining member (256a, 256b) radially outward.

[0028] The upper inner vial adapter wall (260) acts on the valve actuator (226). The valve actuator (226) extends through the outer vial adapter body (220) and the flow control body (206). The valve actuator bore (610) (see FIG. 6) formed within the flow control body (206) is generally elongated and cylindrical. Referring to FIG. 6 through 8, the valve actuator (226) is configured to move up and down in the direction shown within the valve actuator bore (610). When the vial adapter (218) is compressed, the valve actuator (226) is configured to move within the valve actuator bore (610) between a first actuator position and a second actuator position.

[0029] The upper inner vial adapter wall (260) has a pair of diameters of upright members (246a, 246b) that are orthogonal to the pair of diameters of vial crown retaining members (254a, 254b). The pair of diameters of the upright members (246a, 246b) prevents the inner vial adapter body (244) from being inadvertently removed from the outer vial adapter body (220). The vial crown sleeve (266) includes a pair of diameters of clamp members (258a, 258b) that are orthogonal to the pair of diameters of the vial crown retaining members (254a, 254b).

[0030] The outer vial adapter body (220) has an inverted cup shape including an upper outer vial adapter wall (230) and an outer vial adapter skirt (238). The outer vial adapter body (220) is bordered by an outer cavity to additionally accommodate an inner vial adapter body (244) inside when the vial adapter (218) is compressed from a pre-compressed state to a compressed state.

[0031] The upper outer vial adapter wall (230) includes a central connector (222) for insertion into a flow control lumen (1006) and a vial spike (242) providing fluid communication through it. A corresponding flange of the outer vial adapter body (220) is received by a vial adapter flange (208). The upper outer vial adapter wall (230) includes an aperture (232) for the passage of a valve actuator (226).

[0032] The external vial adapter body (220) has a pair of slit diameters for receiving a pair of proximal vial crown retaining members (248a, 248b) in the compressed state of the vial adapter (218), and a pair of slit diameters for receiving a pair of upright members (246a, 246b), such as slit (234).

[0033] The outer vial adapter skirt (238) includes a first pair of adjacent longitudinal slits (228a, 228b) and a second pair of adjacent longitudinal slits (236) opposite the pair of diameters of the adjacent longitudinal slits to correspondingly form a pair of diameters of the inner vial adapter retaining members (240a, 240b) (only one slit is visible in the drawing). As shown in FIG. 9, a fork-shaped safety stopper (210) crosses the first pair of longitudinal slits (228a, 228b) and the second pair of longitudinal slits (236) to prevent consolidation of the telescopic vial adapter.

[0034] A pair of diameters of internal vial adapter retaining members (240a, 240b) has a pair of diameters of internal recesses (1004a, 1004b) to enable movement of the internal vial adapter body (244) within the external vial adapter body (220) (see FIG. 10). A pair of diameters of internal recesses (1004a, 1004b) correspondingly includes a pair of diameters of lower recess rims (1008a, 1008b) (see FIG. 10). In the uncompressed state of the vial adapter (218), a pair of lower recess rims (1008a, 1008b) is configured to accommodate a pair of upright members (246a, 246b) to prevent the internal vial adapter body (244) from being inadvertently removed from the external vial adapter body (220). In the compressed state of the vial adapter (218), a pair of lower recess rims (1008a, 1008b) are configured to receive a pair of clamp members (258a, 258b) to irreversibly clamp the vial adapter (218) in the compressed state.

[0035] The outer vial adapter skirt (238) has a pair of diameters of apertures (224) (only one aperture is visible in the drawing) that are orthogonal to the pair of inner vial adapter retaining members (240a, 240b). The pair of apertures (224) is designed to allow the use of a pincer hand tool (302) (see FIG. 3) to facilitate the manual application of a pincer-type constriction to release an unperforated vial (112).

[0036] The vial spike (242) includes a vial spike lumen (1012) (see FIG. 10) to provide fluid communication with the vial (112) when compressed. The vial spike lumen (1012) is fluidly in communication with the flow control lumen (1006) (see FIG. 10).

[0037] FIG. 3 illustrates a pincer-type hand tool (302) for releasing an unperforated vial (112). The pincer-type hand tool (302) comprises a pincer-type body having opposing pairs of jaws (304a, 304b) each terminated at an inwardly oriented projection (306a, 306b). The opposing pairs of jaws (304a, 304b) can be manually pressed toward each other to apply pincer-type constriction to release the unperforated vial (112).

[0038] FIG. 4 illustrates a pincer-type hand tool (302) having a vial (112), a vial adapter (218), and a fluid reservoir (106).

[0039] If it is decided to reuse the unperforated vial (112) without administering the drug after the vial (112) is attached to the unconstricted liquid delivery device (110), the user may take the following steps. The user aligns a pincer-type hand tool (302) with the vial adapter (218) to insert a pair of inwardly oriented protrusions (306a, 306b) through a pair of apertures (224). The user applies pincer-type constriction to a pair of proximal vial crown retainers (248a, 248b) to apply radially inward pressure. The pair of vial crown retainers (254a, 254b) pivots against the vial crown sleeve (266) to radially outwardly distance the distal vial crown retainers (256a, 256b), thereby releasing the unperforated vial (112). The user removes an unperforated vial (112) from the internal vial adapter body (244) for subsequent use.

[0040] FIG. 5 illustrates a valve (272). FIGS. 5a through 5c illustrate different perspective views of the valve (272). FIG. 5a illustrates a cross-section (508) of the valve (272) to illustrate the lumens (502a, 502b) of the valve (272). An oblique first lumen (502a) is configured to provide fluid communication between the second IV spike lumen (1010) and the flow control lumen (1006) (see FIG. 10). A straight second lumen (502b) is configured to provide fluid communication between the first IV spike lumen (602) and the IV port holder lumen (606) (see FIG. 6). Thus, fluid communication between the IV spike (202) and the vial adapter (218) is separated from fluid communication between the IV spike (202) and the IV port holder (212). The valve (272) may additionally include an oblique surface (506). The valve (272) includes a locking protrusion (504). Both the first lumen (502a) and the second lumen (502b) may be oblique, or depending on the configuration of the liquid delivery device (110), the first lumen (502a) may be straight and the second lumen (502b) may have an angle. The reference to an oblique lumen refers to the first lumen (502a) or the second lumen (502b) having a curvature or change in the direction of flow relative to the straight flow direction or fluid flow path.

[0041] Referring to FIGS. 6 and 7, the valve (272) is movable within the valve cavity (604). The valve cavity (604) is generally cylindrical and elongated. Referring to FIGS. 6 through 8, the valve (272) moves left and right within the valve cavity (604) between a first position (see FIG. 6) and a second position (see FIG. 7). Before consolidation, the locking protrusion (504) engages with the bore (608) to prevent the valve (272) from moving to the left. Upon consolidation, the valve actuator (226) moves within the valve actuator bore (610) between the first actuator position and the second actuator position, as shown in FIGS. 8a and 8b. The valve actuator (226) engages with the oblique surface (506) of the valve (272) to move the valve (272) to the left. As the valve actuator (226) presses against the oblique surface (506) of the valve (272), the locking protrusion (504) is configured to be deflected and thereby disengaged from the bore (608), causing the valve (272) to move from a first position on the right side inside the valve cavity (604) to a second position on the left side.

[0042] The valve (272) is configured to prevent fluid communication between the second IV spike lumen (1010) and the flow control lumen (1006) in a first position (or first state) corresponding to the uncompressed state of the vial adapter (218). That is, the second IV spike lumen (1010), the first lumen (502a) of the valve (272), and the flow control lumen (1006) do not have fluid communication in the first position. Similarly, the valve (272) is configured to prevent fluid communication between the first IV spike lumen (602) and the IV port holder lumen (606) in the first state. That is, the first IV spike lumen (602), the second lumen (502b) of the valve (272), and the IV port holder lumen (606) do not have fluid communication in the first state. As illustrated in FIG. 7, the valve (272) is configured to enable fluid communication between the first IV spike lumen (602) and the IV port holder lumen (606) in a second state (or second position) corresponding to the compressed state of the vial adapter (218). That is, the first IV spike lumen (602), the second lumen (502b), and the IV port holder lumen (606) are fluidly communicating in the second state. Similarly, the valve (272) is configured to enable fluid communication between the second IV spike lumen (1010) and the flow control lumen (1006) in the second state. That is, the second IV spike lumen (1010), the first lumen (502a), and the flow control lumen (1006) are fluidly communicating in the second state.

[0043] Accordingly, when the vial adapter (218) is in a pre-compressed state, fluid communication between the IV spike (202), the vial adapter (218), and the IV port holder (212) is prevented. When the vial adapter (218) is compressed, fluid communication between the IV spike (202), the vial adapter (218), and the IV port holder (212) becomes possible.

[0044] When sliding the valve (272) from a first state to a second state, rotation of the valve (272) inside the valve cavity (604) may result in misalignment of the first lumen (502a) having the second IV spike lumen (1010) and the flow control lumen (1006), as well as misalignment of the second lumen (502b) having the first IV spike lumen (602) and the IV port holder lumen (606). To ensure that the valve (272) maintains its rotational position during sliding, one or more features may be provided on the outer surface of the valve (272) and / or on the inner surface of the valve cavity (604). For example, the inner surface of the valve cavity (604) may be provided with a groove, and the outer surface of the valve (272) may be provided with a corresponding rail (not shown), and vice versa.

[0045] FIG. 8 illustrates a cross-section of the liquid delivery device (110) before and after the compression of the vial adapter (218). As shown in FIG. 8a, the vial adapter (218) is mounted on the vial (112). Upon compression, the inner vial adapter body (244) moves the valve actuator (226) from the first actuator position (see FIG. 8a) to the second actuator position (see FIG. 8b). The valve actuator (226) engages with the oblique surface (506) of the valve (272), causing the valve (272) to move within the valve cavity (604) between the first position (see FIG. 8a) and the second position (see FIG. 8b).

[0046] FIG. 9 illustrates the arrangement of a liquid delivery device (110) having a safety stop (210) across an outer vial adapter body (220) to prevent the vial adapter (218) from being compressed. The vial adapter (218) is in a pre-compressed state, and the valve (272) is in a first position to prevent fluid communication between the IV spike (202), the IV port holder (212), and the vial (112).

[0047] FIG. 10 shows a cross-section of a liquid delivery device (110) coupled to a reservoir (106) and a vial (112).

[0048] FIG. 11 illustrates a liquid delivery device (110) after a user mounts a vial adapter (218), prepared for the preparation of a medicinal infusion liquid within an infusion liquid container (102) for subsequent administration to a patient, onto an infusion vial (112).

[0049] FIG. 12 illustrates a liquid delivery device (110) after the user removes the safety stopper (210) from the outer vial adapter body (220) and compacts the vial adapter (218) so that the outer vial adapter body (220) accommodates the inner vial adapter body (244) inside. The vial spike (242) perforates the vial stopper (270) to provide fluid communication between the vial spike lumen (1012) and the vial (112) to prepare the medicinal infusion liquid. Compaction excludes any subsequent use of a pincer-type hand tool (302) to release the now perforated individual infusion vial (112) because the proximal vial crown retaining member (248a, 248b) will no longer be aligned with the aperture (224).

[0050] Referring to FIG. 12, the safety stopper (210) can be removed before compaction after the inner vial adapter body (244) of the vial adapter (218) is mounted on the vial (112). Subsequently, the vial adapter (218) can be compacted from a pre-compacted state to a compacted state as shown in FIG. 6. A spike (1202) of the infusion set (114) is shown, which can be inserted into the IV port (214) after the distal section (216b) or twist-off cap is removed or twisted.

[0051] The use of the liquid delivery device (110) is now described with reference to FIGS. 3 through 12. A user (e.g., a healthcare professional) inserts the vial (112) into the inner vial adapter body (244) of the vial adapter (218), thereby preparing the liquid delivery device (110) for further use, but allowing the user to leave the liquid delivery device (110) for future use without immediately performing subsequent steps. Inadvertent constriction of the vial adapter (218) of the liquid delivery device (110) is prevented by the safety stopper (210). When the user is ready to mix the contents of the vial (112) with the fluid inside the infusion liquid container (102), the user inserts the IV spike (202) into the intravenous administration port (108) of the infusion liquid container (102) and removes the safety stopper (210). The user compresses the vial adapter by pushing the vial (112) and the inner vial adapter body (244) into the outer vial adapter body (220).

[0052] When the vial adapter (218) is compressed, the vial spike (242) punctures the sheath (264) and subsequently establishes a flow connection between the vial spike (242) and the vial (112) to prepare the medicinal infusion liquid. The user prepares the medicinal infusion liquid in the reservoir (106) of the infusion liquid container (102) by transferring the liquid between the reservoir (106) and the vial (112) through the vial spike lumen (1012), the flow control lumen (1006), the first lumen (502a), and the second IV spike lumen (1010). To administer the medicinal infusion liquid, the user removes the distal section (216b) of the IV port (214) and inserts the infusion set (114) spike (1202) inside. The manufactured medicinal infusion liquid can now be administered to a patient having an infusion set (114) through the first IV spike lumen (602), the second lumen (502b), and the IV port holder lumen (606).

[0053] While specific embodiments of the present invention are illustrated and described, it will be apparent to those skilled in the art that various other changes and modifications may be made without departing from the spirit and scope of the invention.

Claims

Claim 1 A liquid delivery device comprising: an IV spike configured to be connected to an injection liquid container; a compressible vial adapter configured to be mounted on a vial; an IV port configured to be connected to an injection set; and a valve movable between a first state and a second state when the vial adapter is compressed, wherein the valve is configured to prevent fluid communication between the IV spike, the vial adapter, and the IV port in the first state, and wherein the valve is configured to provide fluid communication between a first IV spike lumen of the IV spike and the vial adapter, and fluid communication between a second IV spike lumen of the IV spike and the IV port in the second state. Claim 2 A liquid delivery device according to claim 1, wherein the valve comprises a first lumen configured to provide fluid communication between the first IV spike lumen and the vial adapter, and a second lumen configured to provide fluid communication between the second IV spike lumen and the IV port. Claim 3 A liquid delivery device according to claim 1, wherein the vial adapter comprises a vial spike for perforating the vial stopper of the vial to provide fluid communication with the vial. Claim 4 A liquid delivery device according to paragraph 3, wherein the vial adapter comprises an outer vial adapter body and an inner vial adapter body configured to be mounted on a vial, and the inner vial adapter body is configured to slide within the outer vial adapter body when the vial adapter undergoes consolidation from an unconsolidated state to a consolidated state. Claim 5 A liquid delivery device according to claim 4, wherein the vial spike is configured to puncture the vial stopper when the vial adapter undergoes consolidation. Claim 6 A liquid delivery device according to claim 4, further comprising a valve actuator movable between a first position and a second position, wherein the valve actuator is configured to move from the first position to the second position upon consolidation of the vial adapter. Claim 7 A liquid delivery device according to claim 6, wherein the valve actuator is configured to drive the valve from the first state when the valve actuator is in the first position to the second state when the valve actuator is in the second position during the consolidation of the vial adapter. Claim 8 A liquid delivery device according to claim 6, wherein the valve comprises an oblique surface configured to engage with the valve actuator. Claim 9 A liquid delivery device comprising a safety stop configured to prevent the consolidation of the vial adapter in the unconsolidated state according to any one of claims 4 to 8. Claim 10 A liquid delivery device according to claim 1, further comprising a connector body having the IV spike, the vial adapter, and the IV port coupled thereto, wherein the valve is movable within the connector body between the first state and the second state. Claim 11 A liquid delivery device according to claim 10, wherein the valve further comprises a bore, and the valve further comprises a locking projection, wherein the locking projection is configured to engage with the bore to prevent movement of the valve between the first state and the second state in a pre-compacted state, and the locking projection is configured to be deflected and disengaged from the bore so that the valve can move between the first state and the second state in the compacted state. Claim 12 delete Claim 13 delete

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