Implant composition made of zirconia

Abstract

The present invention relates to an implant composition of zirconia material that can prevent discoloration even under gamma ray irradiation, characterized by comprising yttrium dioxide added to zirconium dioxide, a pentavalent oxide added to reduce oxygen vacancies generated by the yttrium dioxide, a color oxide added to mitigate discoloration, and a tetravalent oxide added to improve sinterability.

Description

Technology Field

[0001] The present invention relates to a dental implant composition, and more particularly to an implant composition made of zirconia material that can prevent discoloration even under gamma ray irradiation. Background Technology

[0002] Previously, metal was primarily used as an artificial tooth material to replace natural teeth; however, ceramic prosthetics were introduced due to their superior aesthetics and ability to produce colors similar to natural teeth. More recently, zirconia has begun to gain popularity as a material for dental implants, as it offers high aesthetics due to its tooth-like color, excellent strength, and is biocompatible with no allergic reactions.

[0003] For the sterilization of zirconia implants, autoclave steam, Sterilization methods such as plasma, ethylene oxide gas, and gamma ray irradiation can be applied. Since the former three methods are effective only on the surfaces where the sterilization media come into contact, there is a process difficulty in that sterilization must be performed at each inner packaging stage to sterilize the implant in a packaged state as required by the Ministry of Food and Drug Safety.

[0004] In contrast, gamma irradiation is the most practical sterilization method because it allows for the sterilization of implants while they are still packaged, but there is a problem where the tooth color turns black due to the excitation of oxygen vacancies, which are color centers within the zirconia, during gamma irradiation, resulting in a loss of aesthetics.

[0005] As a method to restore color changes caused by gamma rays, a method of heat treatment at 60 to 150 degrees is disclosed in German Patent DE10201410, and a method of heat treatment at 100 to 300 degrees is disclosed in Korean Registered Patent Publication No. 10-1640562. However, since heat treatment causes deformation of the packaging material, as a solution to this problem, US Published Patent US 2019 / 0001011 A1 discloses a method of restoring color by irradiation with electromagnetic radiation in the visible light range of 150-700 nm wavelengths.

[0006] If a new method is developed to fundamentally prevent color changes in zirconia implants upon gamma irradiation, separate methods such as heat treatment or radiation therapy to restore the color caused by gamma rays would not be necessary. Prior art literature

[0007] Republic of Korea Registered Patent Publication No. 10-1640562 United States Published Patent Application US 2019 / 0001011 A1 The problem to be solved

[0008] Accordingly, the present invention is an invention conceived in accordance with the aforementioned necessity, and the main objective of the present invention is to provide an implant composition made of zirconia material that can prevent or minimize discoloration of the implant caused by gamma ray irradiation.

[0009] Furthermore, another objective of the present invention is to provide a zirconia implant composition that can increase the success rate by improving bone integration during implantation through an increase in surface tension during the heat treatment process. means of solving the problem

[0010] An implant composition made of zirconia material according to one embodiment of the present invention for achieving the aforementioned purpose is,

[0011] Zirconium dioxide ( ) and, yttrium dioxide ( ) and the above yttrium dioxide having a trivalent oxidation state ( It is characterized by including a pentavalent oxide added to reduce oxygen vacancies caused by Y ions, a color oxide added to mitigate discoloration, and a tetravalent oxide added to increase sinterability.

[0012] Furthermore, in the implant composition of the zirconia material described above, the oxide of the pentavalent ion is niobium pentoside ( Characterized by being ),

[0013] The above-mentioned colored oxide is erbium oxide ( ), Europium oxide ( ), iron oxide ( Characterized as being one of ),

[0014] The oxide of the above tetravalent ion is silicon dioxide ( ) and titanium dioxide( ) and cerium oxide ( It is characterized by including ).

[0015] In addition, in the zirconia material implant composition described above, zirconium dioxide ( ) is 79.0-93.6 mol%, yttrium dioxide ( ) is 3.0 - 6.0 mol%, niobium pentoside ( ) is 3.0 - 10.0 mol%, erbium oxide( ) or europium oxide ( ) or iron oxide ( ) is 0.2 - 2.0 mol%, silicon dioxide( ) and titanium dioxide( Each is 0.01 - 1.0 mol%, cerium oxide ( ) is characterized by including a content range of 0.2 - 2.0 mol%, and being mixed such that the total mol% of the entire mixture included is 100 mol%. Effects of the invention

[0016] According to the means for solving the technical problem described above, the present invention can minimize discoloration caused by gamma ray irradiation by changing the composition of the zirconia implant material to reduce the number of oxygen vacancies that cause discoloration, and at the same time adding color oxides to mitigate discoloration to black.

[0017] Furthermore, by increasing surface tension through an additional heat treatment process during manufacturing, it provides the effect of improving osseointegration during implant placement, thereby increasing the success rate. Brief explanation of the drawing

[0018] FIG. 1 is an example diagram of the color change before and after gamma ray irradiation of a zirconia implant sample according to an embodiment of the present invention. FIG. 2 is a diagram showing the contact angle and surface free energy changes before and after gamma ray irradiation and during heat treatment for an implant sample made of zirconia material according to an embodiment of the present invention. FIG. 3 is a graph showing the change in surface free energy according to the heat treatment temperature after gamma ray irradiation for an implant sample made of zirconia material according to an embodiment of the present invention. Specific details for implementing the invention

[0019] The following detailed description of the present invention refers to the accompanying drawings, which illustrate specific embodiments in which the present invention can be practiced in order to clarify the objects, technical solutions, and advantages of the present invention. These embodiments are described in sufficient detail to enable a person skilled in the art to practice the present invention.

[0020] Furthermore, throughout the detailed description and claims of the invention, the word “comprising” and its variations are not intended to exclude other technical features, additions, components, or steps. Other objects, advantages, and characteristics of the invention will become apparent to a person skilled in the art, in part from this description and in part from the practice of the invention. The following examples and drawings are provided as examples and are not intended to limit the invention. Moreover, the invention encompasses all possible combinations of the embodiments set forth herein. It should be understood that various embodiments of the invention are different but need not be mutually exclusive. Accordingly, the following detailed description is not intended to be limiting, and the scope of the invention is limited only by the appended claims, including all equivalents to those claimed therein, provided they are properly described.

[0021] Figure 1 illustrates the color change of a zirconia implant sample before and after gamma irradiation according to an embodiment of the present invention, Figure 2 illustrates the contact angle and surface free energy change of a zirconia implant sample before and after gamma irradiation and during heat treatment according to an embodiment of the present invention, and Figure 3 is a graph showing the change in surface free energy according to the heat treatment temperature after gamma irradiation of a zirconia implant sample according to an embodiment of the present invention.

[0022] Generally, changes in the composition of zirconia have the problem of increasing the deterioration of mechanical properties or vulnerability to low-temperature degradation. In the embodiments of the present invention, additives that solve the discoloration problem of zirconia implants sterilized by gamma irradiation are presented, and examples of discoloration prevention and changes in mechanical properties are described.

[0023] First, the above additives can reduce oxygen vacancies caused by Y ions, which are trivalent oxidation states originally added to zirconia, the implant material, by adding oxides of pentavalent ions. Additionally, as shown in Fig. 1, color oxides are added to mitigate discoloration to black, thereby minimizing discoloration caused by gamma irradiation. Furthermore, during the additional heat treatment process, surface tension is increased to improve osseointegration during implant placement, which can increase the success rate.

[0024] To explain this more specifically, the zirconia material implant composition according to an embodiment of the present invention is,

[0025] Zirconium dioxide ( ) and, yttrium dioxide ( ) and, the above yttrium dioxide ( It includes a pentavalent ion oxide added to reduce oxygen vacancies caused by ), a color oxide added to mitigate discoloration, and a tetravalent ion oxide added to increase sinterability.

[0026] The oxide of the above pentavalent ion is niobium pentoside ( ) and the above-mentioned color oxide is erbium oxide ( ), Europium oxide ( ), iron oxide ( It can be any one of the following.

[0027] The oxide of the above tetravalent ion is silicon dioxide ( ) and titanium dioxide( ) and cerium oxide ( Includes ). Silicon dioxide ( ) and titanium dioxide( ) is an additive that helps improve sinterability, and cerium oxide ( ) acts as a color oxide.

[0028] The composition, oxide type, and content range for the zirconia implant composition according to an embodiment of the present invention are as follows.

[0029] Zirconium dioxide ( ) is 79.0 - 93.6 mol%, yttrium dioxide, a trivalent ion oxide corresponding to a zirconia stabilizer ( ) is 3.0 - 6.0 mol%, niobium pentoside, a pentavalent ion oxide ( ) is 3.0 - 10.0 mol%, erbium oxide as a color oxide for gingival color realization ( ), Europium oxide ( ), iron oxide ( One of ) is 0.2 - 2.0 mol%, silicon dioxide which is a tetravalent ion oxide ( ) and titanium dioxide( Each is 0.01 - 1.0 mol%, cerium oxide ( ) is mixed in a content range of 0.2 - 2.0 mol%, such that the total mol% of the entire mixture is 100 mol%.

[0030] [Example]

[0031] Below, we will compare the composition of a zirconia implant sample (referred to as the sample of the present invention) according to one embodiment of the present invention with that of a control sample (3Y-TZP, tosoh cop). The compositions of the zirconia implant sample according to the embodiment of the present invention and the control sample are as described in Table 1 below.

[0032] Sample of the present invention molar concentration 91.19 4.41 3.28 0.18 0.27 0.46 0.21 control group sample molar concentration 93.64 3 3.1 0.13 0.04 0.01 0.08

[0033] First, the color change of the sample of the present invention and the control sample before and after gamma ray irradiation is as shown in FIG. 1. As shown in Table 1 above, the zirconia implant sample according to an embodiment of the present invention is yttrium dioxide, a trivalent ion oxide that is originally added to zirconia ( The number of oxygen vacancies generated by ) is niobium pentoside, a pentavalent ion oxide ( In addition to reducing the amount by adding a color oxide, the effect of minimizing the discoloration of the sample to black by gamma irradiation can be obtained when compared to the control sample (3Y-TZP) of Fig. 1.

[0034] Meanwhile, referring to Fig. 2, which shows the water contact angle and surface free energy measured for the sample of the present invention before and after gamma ray irradiation and after heat treatment, before gamma ray irradiation (before sterilization) and after irradiation, class It was found that the contact angle between them decreased, and the surface free energy increased relatively.

[0035] In addition, it was found that the surface free energy increased when an additional heat treatment process was performed on gamma-ray irradiated samples, indicating that the surface tension can be increased during the additional heat treatment process to improve osseointegration during implant placement.

[0036] Figure 3 shows a graph of the change in surface free energy according to the heat treatment temperature after gamma ray irradiation, indicating that the surface free energy increases rapidly in the range where the room temperature is 150°C or higher.

[0037] According to the above embodiments, the present invention can minimize discoloration caused by gamma ray irradiation by changing the composition of the zirconia implant material to reduce the number of oxygen vacancies that cause discoloration, and simultaneously adding color oxides to mitigate discoloration to black. Furthermore, by increasing surface tension through an additional heat treatment process during the manufacturing process, it is possible to obtain the effect of improving bone integration during implant placement and increasing the success rate.

[0038] For reference, to further explain the manufacturing process of an implant having the composition ratios described in Table 1 above,

[0039] First, zirconium dioxide, which corresponds to the raw material ( ), yttrium dioxide( ) and niobium pentoside ( ) prepare and mix them, then perform solution treatment, and silicon dioxide, which is a sintering aid ( ) and titanium dioxide( ) and cerium oxide, a colored oxide ( ) and erbium oxide ( After adding ), an injection molding process is performed to realize the shape of the implant.

[0040] Next, a degreasing and sintering process is performed to remove organic matter and impart sintering properties, a HIP and heat treatment process is performed for densification and color recovery, and after irradiating with gamma rays for sterilization, a heat treatment process is performed for color recovery.

[0041] Although the present invention has been described with reference to embodiments illustrated in the drawings, this is merely illustrative, and those skilled in the art will understand that various modifications and equivalent alternative embodiments are possible therefrom. For example, while the embodiments of the present invention have exemplified dental implants, the embodiments of the present invention can be equally applied to surgical prosthetics. Accordingly, the true technical scope of protection of the present invention should be determined by the technical spirit of the appended claims.

Claims

Claim 1 Zirconium dioxide ( ) and, yttrium dioxide ( ) and, the above yttrium dioxide ( It includes a pentavalent ion oxide added to reduce oxygen vacancies generated by ), a color oxide added to mitigate discoloration, and a tetravalent ion oxide added to increase sinterability, wherein the tetravalent ion oxide is silicon dioxide ( ) and titanium dioxide( ) and cerium oxide ( An implant composition made of zirconia material characterized by including ). Claim 2 In claim 1, the oxide of the pentavalent ion is niobium pentoside ( An implant composition made of zirconia material characterized by being ). Claim 3 In claim 1, the color oxide is erbium oxide ( ), Europium oxide ( ), iron oxide ( An implant composition made of zirconia material characterized as being any one of the following. Claim 4 delete Claim 5 In claim 1, the oxide of the pentavalent ion is niobium pentoside ( ) and the above-mentioned color oxide is erbium oxide ( ), Europium oxide ( ), iron oxide ( An implant composition made of zirconia material characterized as being any one of the following. Claim 6 In claim 5, the zirconium dioxide ( ) is 79.0 - 93.6 mol%, the above yttrium dioxide ( ) is 3.0 - 6.0 mol%, the above niobium pentoside ( ) is 3.0 - 10.0 mol%, the above erbium oxide ( ), Europium oxide ( ), iron oxide ( Any one of ) is 0.2 - 2.0 mol%, the above silicon dioxide ( ) and titanium dioxide( Each of ) is 0.01 - 1.0 mol%, the above cerium oxide ( An implant composition made of zirconia material, characterized in that ) is mixed in a content range of 0.2 - 2.0 mol%, and the total mol% of the entire mixture is 100 mol%.

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