Temperature Control Device and HIPEC Treatment Device Comprising the Same

Abstract

According to one embodiment of the present disclosure, a temperature control device is provided comprising: a temperature sensor for sensing the temperature of a fluid flowing inside an outflow catheter; a first TVC for converting the detected temperature sensed by the temperature sensor into an analog signal; a first ADC for converting the analog signal converted by the first TVC into a detected temperature pulse signal; a reference temperature generator for generating thermal energy having a reference temperature; a second TVC for converting the reference temperature into an analog signal; a second ADC for converting the analog signal converted by the second TVC into a reference temperature pulse signal; a temperature difference comparison detector for generating a temperature difference pulse signal by inputting the detected temperature pulse signal and the reference temperature pulse signal into a logic operator; a control command generator for generating a control command corresponding to the temperature difference pulse signal; and a heat exchanger disposed on an inflow catheter and operated or deactivated in response to the control command.

Description

Technology Field

[0001] The present disclosure relates to a temperature control device, and specifically to a temperature control device used in a HIPEC surgical device. Background Technology

[0003] The content described in this section merely provides background information regarding the present disclosure and does not constitute prior art.

[0004] Hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment method in which high-temperature anticancer agents are directly circulated within the abdominal cavity for a certain period of time to kill residual tumors that may remain after the surgical removal of the visually identifiable cancerous area. At this time, in order to effectively remove residual tumors, the temperature of the anticancer agent injected into the body must be at an appropriate temperature capable of killing cells. Here, the appropriate temperature is 41°C to 43°C.

[0005] Meanwhile, even if a drug at 43°C is injected, the temperature within the abdominal cavity decreases to 41°C or lower, raising concerns that the therapeutic effect of heat killing on residual tumors may be reduced. To address this, directly or indirectly monitoring the temperature of the drug within the abdominal cavity is very important in HIPEC treatment.

[0006] Meanwhile, for this purpose, according to KR 10-2354223 B1, a first sensor for measuring the temperature of the gas in the abdominal cavity, a second temperature sensor for measuring the temperature of the circulation unit that circulates the gas, and a third temperature sensor for measuring the temperature of the gas supplied to the gas injection device are provided for close temperature observation during HIPEC treatment. However, if multiple sensors are provided in this way, there is a high risk of sensor errors and a problem that manufacturing costs increase.

[0007] In addition, since cell necrosis occurs at temperatures above 44°C, there is a growing demand for a treatment device that can sense the temperature in real time and respond immediately to excessively low or excessively high temperatures.

[0009] (Patent Document 1) KR 10-2354223 B1 The problem to be solved

[0011] Accordingly, the present disclosure aims to provide a temperature control device capable of sensing the temperature in real time and providing an appropriate temperature to the affected area, and a HIPEC treatment device including the same.

[0012] The problems that the present invention aims to solve are not limited to those mentioned above, and other unmentioned problems will be clearly understood by a person skilled in the art from the description below. means of solving the problem

[0014] According to one embodiment of the present disclosure, a temperature control device is provided comprising: a temperature sensor for sensing the temperature of a fluid flowing inside an outflow catheter; a first TVC for converting the detected temperature sensed by the temperature sensor into an analog signal; a first ADC for converting the analog signal converted by the first TVC into a detected temperature pulse signal; a reference temperature generator for generating thermal energy having a reference temperature; a second TVC for converting the reference temperature into an analog signal; a second ADC for converting the analog signal converted by the second TVC into a reference temperature pulse signal; a temperature difference comparison detector for generating a temperature difference pulse signal by inputting the detected temperature pulse signal and the reference temperature pulse signal into a logic operator; a control command generator for generating a control command corresponding to the temperature difference pulse signal; and a heat exchanger disposed on an inflow catheter and operated or deactivated in response to the control command.

[0015] Additionally, preferably, when the reference temperature pulse signal of the present disclosure is 0 and the detected temperature pulse signal is 0, the temperature difference pulse signal is 1, the control command generating unit generates a temperature maintenance control command, and the heat exchanger operates to maintain the temperature of the fluid flowing inside the inlet catheter in response to the temperature maintenance control command.

[0016] Additionally, preferably, if the reference temperature pulse signal of the present disclosure is 0 and the detected temperature pulse signal is 1, the temperature difference pulse signal is 0, the control command generating unit generates a temperature increase control command, and the heat exchanger operates to increase the temperature of the fluid flowing inside the inlet catheter in response to the temperature increase control command.

[0017] Additionally, preferably, if the reference temperature pulse signal of the present disclosure is 1 and the detected temperature pulse signal is 0, the temperature difference comparison detection unit determines that the detected temperature is greater than or equal to the first reference, the control command generation unit generates a temperature reduction control command, and the heat exchanger operates to reduce the temperature of the fluid flowing inside the inlet catheter in response to the temperature reduction control command.

[0018] Additionally, preferably, if the reference temperature pulse signal of the present disclosure is 1 and the detected temperature pulse signal is 1, the temperature difference comparison detection unit determines that the detected temperature is greater than or equal to a second reference, the control command generation unit generates a function stop control command, and the heat exchanger stops operating in response to the function stop control command, wherein the second reference is a temperature higher than the first reference.

[0019] Additionally, preferably, the temperature difference comparison detection unit of the present disclosure comprises: an amplifier; an input resistor disposed at the input terminal of the amplifier and an input capacitor connected in series with the input resistor; a feedback resistor disposed between the input terminal and the output terminal of the amplifier and a feedback capacitor connected in parallel with the feedback resistor; and an XNOR gate disposed at the output terminal of the amplifier.

[0020] In addition, a HIPEC treatment device including a temperature control device according to one embodiment of the present disclosure is provided. Effects of the invention

[0022] As described above, according to one embodiment of the present disclosure, a temperature sensor senses the temperature of an outflow catheter in real time, and a temperature difference comparison detection unit compares the sensed temperature with a reference temperature to generate a control command, thereby having the effect of controlling the temperature with a very fast response speed.

[0023] In addition, since the temperature control device according to one embodiment of the present disclosure and the HIPEC treatment device including it only need to be equipped with a single temperature sensor, the amount of computation is small, the response speed is fast, and the manufacturing cost is reduced. Brief explanation of the drawing

[0025] FIG. 1 is a block diagram of a HIPEC treatment device according to one embodiment of the present disclosure. FIG. 2 is a block diagram showing a temperature difference comparison detection unit, a control command generation unit, and a heat exchanger according to one embodiment of the present disclosure. FIG. 3 and FIG. 4 show the results of computational processing using the HIPEC treatment device according to one embodiment of the present disclosure. FIG. 5 and FIG. 6 show the processing speed when computational processing is performed using the HIPEC treatment device according to one embodiment of the present disclosure. FIG. 7 shows the results of thermal imaging of an outflow catheter according to one embodiment of the present disclosure. FIG. 8 is a flowchart of a temperature control method using the HIPEC treatment device according to one embodiment of the present disclosure. Specific details for implementing the invention

[0026] Some embodiments of the present disclosure are described in detail below with reference to the exemplary drawings. It should be noted that in assigning reference numerals to the components of each drawing, the same components are given the same reference numeral whenever possible, even if they are shown in different drawings. Furthermore, in describing the present disclosure, if it is determined that a detailed description of related known components or functions could obscure the essence of the present disclosure, such detailed description is omitted.

[0027] In describing the components of the embodiments according to the present disclosure, symbols such as first, second, i), ii), a), b), etc., may be used. These symbols are intended only to distinguish the components from other components, and the essence, order, or sequence of the components is not limited by the symbols. When a part in the specification is described as 'comprising' or 'having' a component, this means that, unless explicitly stated otherwise, it does not exclude other components but may include additional components.

[0028] FIG. 1 is a block diagram of a HIPEC treatment device according to one embodiment of the present disclosure.

[0029] Referring to FIG. 1, a HIPEC treatment device (1) according to one embodiment of the present disclosure includes an inflow catheter (100), an outflow catheter (110), and a temperature sensor (120).

[0030] An inflow catheter (100) is formed to inject a drug (L) into the abdominal cavity. At this time, the drug (L) introduced into the abdominal cavity may be, for example, an anticancer drug, but is not necessarily limited thereto. The drug (L) introduced into the abdominal cavity flows through the inside of the organ and is then discharged outside the organ.

[0031] An outflow catheter (110) is formed to discharge a drug (L) flowing within the abdominal cavity to the outside of the body.

[0032] A temperature sensor (120) is placed on the outflow catheter (110) and is configured to sense the temperature of the drug (L) flowing through the outflow catheter (110).

[0033] A HIPEC treatment device (1) according to one embodiment of the present disclosure further includes a configuration for controlling the temperature of a drug (L) that is discharged by an discharge catheter (110).

[0034] Specifically, the HIPEC treatment device (1) includes a first TVC (130, Thermal Voltage Converter) and a first ADC (140, Analog-to-Digital Converter).

[0035] The first TVC (130) is configured to convert information regarding the temperature sensed by the temperature sensor (120) into an analog signal.

[0036] The first ADC (140) is configured to convert the analog signal converted by the first TVC (130) into a digital pulse signal. Hereinafter, the pulse signal generated by the first ADC (140) is referred to as T0.

[0037] Additionally, the HIPEC treatment device (1) includes a reference temperature generating unit (150), a second TVC (160), and a second ADC (170).

[0038] The reference temperature generating unit (150) is configured to generate thermal energy corresponding to the reference temperature (HG). At this time, the reference temperature may be, for example, 42°C, but may vary depending on the type of drug (L), etc.

[0039] The second TVC (160) is configured to generate an analog signal corresponding to the reference temperature (HG).

[0040] The second ADC (170) is configured to convert the analog signal converted by the second TVC (160) into a digital pulse signal. Hereinafter, the pulse signal generated by the second ADC (170) is T ref It is referred to as...

[0041] Additionally, the HIPEC treatment device (1) further includes a temperature difference comparison detection unit (180), a control command generation unit (190), and a heat exchanger (200).

[0042] The temperature difference comparison detection unit (180) is T0 and T ref By comparing T0 and T ref It is configured to calculate the temperature difference and convert it into a digital pulse signal. Below, the pulse signal generated by the temperature difference comparison detection unit (180) is T dif It is referred to as...

[0043] The control command generation unit (190) is T dif Receive input, T dif It is configured to generate a control command corresponding to. Preferably, the control command generating unit (190) uses a look-up table (hereinafter, "LUT") to generate the input T dif A control command corresponding to can be generated. The control command generated by the control command generation unit (190) is transmitted to the heat exchanger (200). At this time, the control command may include all or part of the control commands for 'increase temperature', 'stop function', 'maintain temperature', and 'decrease temperature'.

[0044] The heat exchanger (200) is configured to operate in response to a received control command. When the heat exchanger (200) receives a temperature increase control command (Tp), the heat exchanger (200) operates so that the temperature of the drug (L) flowing in through the inflow catheter (100) increases above the current temperature.

[0045] When the heat exchanger (200) receives a function stop control command (Tx), the operation of the heat exchanger is stopped.

[0046] When the heat exchanger (200) receives a temperature maintenance control command (Ts), the heat exchanger (200) operates so that the temperature of the drug (L) flowing in through the inflow catheter (100) is maintained at the current temperature. This is explained in detail in FIG. 6.

[0047] When the heat exchanger (200) receives a temperature reduction control command (Ta), the heat exchanger (200) operates so that the temperature of the drug (L) flowing in through the inflow catheter (100) is reduced from the current temperature.

[0049] FIG. 2 is a block diagram showing a temperature difference comparison detection unit, a control command generation unit, and a heat exchanger according to one embodiment of the present disclosure.

[0050] Referring to FIG. 2, the detailed configuration of the temperature difference comparison detection unit (180), the control command generation unit (190) of the temperature difference comparison detection unit (180), and the method of transmitting and receiving signals with the heat exchanger (200) will be explained.

[0051] The temperature difference comparison detection unit (180) is a reference temperature pulse signal (T ref When (, 108) is received as input, the temperature difference pulse signal (T dif , 20) is configured to output. To this end, the temperature difference comparison detection unit (180) is configured to output an input resistance (R in ), input capacitor (C in ), feedback resistance (R f ), feedback capacitor (C f It includes all or part of the amplifier (181) and XNOR gate (182).

[0052] Input resistance (R in ) and input capacitor (C in ) is placed at the input terminal of the amplifier (181) and can form an RC filter.

[0053] Feedback resistance (R f ) and feedback capacitor (C f ) is placed between the output and input terminals of the amplifier (181) and forms a feedback loop. The feedback loop is a reference temperature pulse signal (T) filtered by an RC filter.ref When the , 108) passes through the amplifier (181), the difference between the input and output can be minimized while maintaining high gain and stability.

[0054] The amplifier (181) may preferably be an amplifier having a large open-loop voltage gain.

[0055] The XNOR gate (182) receives the reference temperature pulse signal (T) output from the amplifier (181). ref By performing an exclusive operation on the (, 108) and the detected temperature pulse signal (T0, 10), the temperature difference pulse signal (T dif , 20) is generated and transmitted to the control command generation unit (190).

[0056] The control command generation unit (190) receives the temperature difference pulse signal (T dif Generates control commands (Tp, Tx, Ts, Ta) corresponding to , 20).

[0057] The control commands (Tp, Tx, Ts, Ta) generated by the control command generation unit (190) are transmitted to the heat exchanger (200).

[0059] FIGS. 3 and 4 show the results of computational processing using a HIPEC treatment device according to one embodiment of the present disclosure.

[0060] Referring to FIGS. 3 and 4, the process of the temperature difference comparison detection unit (180) performing calculations is described. Referring to FIG. 3, a clock signal (CK, 50) may be provided during the calculation process of the temperature difference comparison detection unit (180). At this time, the clock signal (CK, 50) is provided by an oscillator (not shown) or a clock generator (not shown).

[0061] Reference temperature pulse signal (T ref When , 108) is 0 and the detected temperature pulse signal (T0, 10) is 0, the temperature difference pulse signal (T dif, 20) is output as 1. This signal is transmitted to the control command generation unit (190), and the control command generation unit (190) determines that the temperature of the drug (L) is within the appropriate range, generates a temperature maintenance control command (Ts), and transmits it to the heat exchanger (200). The heat exchanger (200) operates to maintain the temperature of the drug (L) flowing in through the inflow catheter (100) in response to the temperature maintenance control command (Ts).

[0062] Reference temperature pulse signal (T ref When , 108) is 0 and the detected temperature pulse signal (T0, 10) is 1, the temperature difference pulse signal (T dif ..., 20) is output as 0. This signal is transmitted to the control command generation unit (190), and the control command generation unit (190) determines that the temperature of the drug (L) is 41 ℃ or lower, generates a temperature increase control command (Tp), and transmits it to the heat exchanger. The heat exchanger (200) increases the temperature of the drug (L) flowing in through the inflow catheter (100) in response to the temperature increase control command (Tp).

[0063] Reference temperature pulse signal (T ref When , 108) is 1 and the detected temperature pulse signal (T0, 10) is 0, the temperature difference pulse signal (T dif , 20) is output as a signal meaning '43 ℃ or higher'. This signal is transmitted to the control command generation unit (190), and the control command generation unit (190) generates a temperature reduction control command (Ta) and transmits it to the heat exchanger (200). The heat exchanger (200) reduces the temperature of the drug (L) flowing in through the inflow catheter (100) in response to the temperature reduction control command (Ta).

[0064] Reference temperature pulse signal (T ref When , 108) is 1 and the detected temperature pulse signal (T0, 10) is 1, the temperature difference pulse signal (T dif, 20) is output as a signal meaning '44 ℃ or higher'. This signal is transmitted to the control command generation unit (190), and the control command generation unit (190) generates a function stop control command (Tx) and transmits it to the heat exchanger. The heat exchanger (200) stops its function in response to the function stop control command (Tx).

[0066] FIGS. 5 and 6 show the processing speed when computationally processed using a HIPEC treatment device according to one embodiment of the present disclosure.

[0067] Referring to FIG. 5, when a clock signal (CK, 50) is supplied, a reference temperature pulse signal (T ref Temperature difference pulse signal (T) extracted through comparison of , 108) and the detected temperature pulse signal (T0, 10) dif This relates to a response signal of , 20), and it is confirmed that the response signal responds at a fast speed without any delay. Specifically, the temperature difference pulse signal (T dif The delay time (T, 53) between the time taken for the rising edge (T1) and the time taken for the falling edge (T2) of the , 20) is approximately 0.209 μs. Since this value is very small compared to the standard delay signal minimization time of 1 μs, it can be seen that the HIPEC treatment device (1) according to the present disclosure has a very fast response speed.

[0068] Referring further to FIG. 6, the HIPEC treatment device (1) according to the present disclosure shows a temperature change (60) resulting from controlling a heat exchanger (200) using a temperature difference comparison detection unit (180) and a control command generation unit (190). At this time, 1.0 on the vertical axis of the graph showing the temperature change (60) means 44 ℃, 0.5 means 42 ℃, and 0.0 means 39 ℃. Referring to FIG. 6, it can be seen that the temperature change (60) is maintained at 0.5, that is, around 42 ℃.

[0070] FIG. 7 shows the results of a thermal imaging of an outflow catheter according to one embodiment of the present disclosure. Referring to FIG. 7, it can be seen that the temperature of the outflow catheter (110) is maintained at 41°C to 43°C. That is, the HIPEC treatment device (1) according to the present disclosure can generate a control command at a rapid speed by checking the temperature of the outflow catheter (110) in real time and comparing it with a reference temperature. Through the generated control command, the temperature of the drug (L) flowing in through the inflow catheter (100) can be controlled in real time, thereby maintaining the appropriate temperature of the drug (L) (preferably 41°C to 43°C).

[0072] FIG. 8 is a flowchart of a temperature control method using a HIPEC treatment device according to one embodiment of the present disclosure.

[0073] Referring to FIG. 8, a HIPEC treatment device (1) according to one embodiment of the present disclosure detects the temperature of a drug (L) discharged through an outflow catheter (110) through a temperature sensor (120) (S800).

[0074] The temperature of the drug (L) detected by the first TVC (130) is converted into an analog signal, and the analog signal is converted into a digital pulse signal by the first ADC (140) to generate (S810). Hereinafter, the digital pulse signal generated by step S810 is referred to as the detected temperature pulse signal (T0, 10).

[0075] Independently of the temperature being detected by the temperature sensor (120), a reference temperature is generated by the reference temperature generating unit (150) (S820).

[0076] The reference temperature is converted into an analog signal by the second TVC (160), and the analog signal is converted into a digital pulse signal (T) by the second ADC (170). ref It is converted into and generated as ) (S830). Below, the digital pulse signal generated by step S830 is, reference temperature pulse signal (T refIt is referred to as , 108).

[0077] Detected temperature pulse signal (T0, 10) and reference temperature pulse signal (T ref Referring to , 108), the temperature difference comparison detection unit (180) calculates the temperature difference (S840). At this time, the temperature difference comparison detection unit (180) can calculate the temperature difference using an XNOR gate.

[0078] Temperature difference pulse signal (T) corresponding to the calculated temperature difference dif , 20) is generated by the temperature difference comparison detection unit (180) (S850).

[0079] Temperature difference pulse signal (T dif Control commands (Tp, Tx, Ts, Ta) corresponding to , 20) are generated by the control command generation unit (190) (S860). At this time, the control command generation unit (190) uses a look-up table to generate the input temperature difference pulse signal (T dif It can output control commands (Tp, Tx, Ts, Ta) for , 20).

[0080] The control command (Tp, Tx, Ts, Ta) generated by the control command generation unit (190) is transmitted to the heat exchanger (200), and the heat exchanger (200) is controlled to correspond to the control command (Tp, Tx, Ts, Ta) (S870).

[0082] The above description is merely an illustrative explanation of the technical concept of the present embodiment, and a person skilled in the art to which the present embodiment belongs would be able to make various modifications and variations within the scope of the essential characteristics of the present embodiment. Accordingly, the present embodiments are intended to explain, not limit, the technical concept of the present embodiment, and the scope of the technical concept of the present embodiment is not limited by these embodiments. The scope of protection of the present embodiment shall be interpreted by the claims below, and all technical concepts within an equivalent scope shall be interpreted as being included within the scope of rights of the present embodiment. Explanation of the symbols

[0084] 1: Treatment device 100: Inflow catheter 110: Outflow catheter 120: Temperature sensor 130: 1st TVC 140: 1st ADC 150: Reference temperature generator 160: 2nd TVC 170: 2nd ADC 180: Temperature difference comparison detection unit 190: Control command generation unit 200: Heat exchanger

Claims

Claim 1 A temperature sensor for sensing the temperature of a fluid flowing inside an outflow catheter; a first TVC (Thermal Voltage Converter) for converting the detected temperature sensed by the temperature sensor into an analog signal; a first ADC (Analog-to-Digital Converter) for converting the analog signal converted by the first TVC into a detected temperature pulse signal; a reference temperature generator for generating thermal energy having a reference temperature; a second TVC for converting the reference temperature into an analog signal; a second ADC for converting the analog signal converted by the second TVC into a reference temperature pulse signal; a temperature difference comparison detector for generating a temperature difference pulse signal by inputting the detected temperature pulse signal and the reference temperature pulse signal into a logic operator; a control command generator for generating a control command corresponding to the temperature difference pulse signal; and a heat exchanger disposed on an inflow catheter and operated or deactivated in response to the control command; wherein the temperature difference comparison detector comprises: an amplifier through which the reference temperature pulse signal passes; an input resistor disposed at the input terminal of the amplifier and an input capacitor connected in series with the input resistor; A feedback resistor disposed between the input and output terminals of the amplifier and a feedback capacitor connected in parallel to the feedback resistor; and an XNOR gate disposed at the output terminal of the amplifier, which generates a temperature difference pulse signal by performing an exclusive operation on a reference temperature pulse signal output from the amplifier and a detected temperature pulse signal converted by the first ADC and transmits it to the control command generation unit;It includes, wherein there exists a predetermined delay time between the time required for the rising edge and the time required for the falling edge of the temperature difference pulse signal generated through the comparison of the reference temperature pulse signal and the detected temperature pulse signal, and if the reference temperature pulse signal is 0 and the detected temperature pulse signal is 0, the temperature difference pulse signal is 1, and the control command generating unit determines that the fluid is at the reference temperature and generates a maintenance control command, and the heat exchanger operates to maintain the temperature of the fluid flowing inside the inlet catheter at the reference temperature in response to the temperature maintenance control command, and if the reference temperature pulse signal is 0 and the detected temperature pulse signal is 1, the temperature difference pulse signal is 0, and the control command generating unit determines that the fluid is below the reference temperature and generates a temperature increase control command, and the heat exchanger operates to increase the temperature of the fluid flowing inside the inlet catheter to the reference temperature in response to the temperature increase control command, and if the reference temperature pulse signal is 1 and the detected temperature pulse signal is 0, the temperature difference A temperature control device comprising: a comparison detection unit determining that the detected temperature is greater than or equal to a first reference; a control command generating unit generating a temperature reduction control command; a heat exchanger operating to reduce the temperature of the fluid flowing inside the inlet catheter in response to the temperature reduction control command; and, if the reference temperature pulse signal is 1 and the detected temperature pulse signal is 1, a temperature difference comparison detection unit determining that the detected temperature is greater than or equal to a second reference; a control command generating unit generating a function stop control command; and a heat exchanger stopping operation in response to the function stop control command, wherein the second reference is a temperature higher than the first reference. Claim 2 delete Claim 3 delete Claim 4 delete Claim 5 delete Claim 6 delete Claim 7 Intraperitoneal hyperthermic anticancer chemotherapy (HIPEC) treatment device comprising a temperature control device according to claim 1.

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