Particles containing H2O2 and method for preparing the same

Abstract

The present application relates to a method for manufacturing hydrogen peroxide-containing particles and particles manufactured therefrom. According to the present application, hydrogen peroxide can be primarily stabilized within the particles by hydrogen bonding with a hydrogen peroxide stabilizer, and because the solidified shellac forms the shell (outer shape) of the particles, the hydrogen peroxide can be stably fixed within the particles.

Description

Technology Field

[0001] The present application relates to particles containing hydrogen peroxide and a method for manufacturing the same. Background Technology

[0002] Hydrogen peroxide, which has excellent bleaching and antibacterial properties, can be used for various purposes. For example, hydrogen peroxide is included in oral hygiene products intended for teeth whitening, including toothpaste. However, since hydrogen peroxide is easily decomposed by strong radical reactions, it is difficult to ensure its stability. Until now, hydrogen peroxide has been stabilized in oral hygiene products by creating weakly acidic pH conditions where it can exist stably or by using polymers such as poly(vinylpyrrolidone) (PVP), which has good compatibility with hydrogen peroxide; however, other technologies for stabilizing hydrogen peroxide have been limited. The problem to be solved

[0003] One objective of the present application is to provide particles that stably contain hydrogen peroxide and a method for manufacturing the same.

[0004] Another objective of the present application is to provide micro-sized particles containing hydrogen peroxide and a method for manufacturing the same.

[0005] Another objective of the present application is to provide a composition comprising the above particles.

[0006] Another objective of the present application is to provide an article comprising the said particle or composition.

[0007] The above-mentioned purpose of the present application and other other purposes can all be resolved by the present application described in detail below. means of solving the problem

[0008] In one example relating to the present application, the present application relates to a method for manufacturing hydrogen peroxide-containing particles.

[0009] The method of the present application provides particles stably containing hydrogen peroxide using a mixture of a dispersed phase and a continuous phase. Specifically, the method of the present application comprises hydrogen peroxide, a hydrogen peroxide stabilizer, shellac, and a solvent (S A The method includes the step of mixing a dispersed phase composition (A) containing ) with a continuous phase composition (B) to form droplets of the dispersed phase composition (A) within the continuous phase composition (B). According to the present application, hydrogen peroxide with unstable characteristics can exist in a stable state within the dispersed phase by means of a hydrogen peroxide stabilizer, and after particles are formed following mixing of the dispersed phase and the continuous phase, the hydrogen peroxide can be fixed within the particles.

[0010] The above hydrogen peroxide is a substance that possesses antibacterial and bleaching powers. Due to these antibacterial and bleaching powers, hydrogen peroxide provides functions such as, for example, oral hygiene products or whitening products.

[0011] Although not specifically limited, for example, the hydrogen peroxide may be included in an amount of 1 to 50 weight% in the dispersed phase composition (A) based on 100 weight% of the total content of the dispersed phase. Specifically, the lower limit of the content of the hydrogen peroxide may be, for example, 5 weight% or more, 10 weight% or more, or 15 weight% or more. And, the upper limit may be, for example, less than 50 weight%, specifically 45 weight% or less, or 40 weight% or less.

[0012] The above hydrogen peroxide stabilizer may refer to a substance capable of forming hydrogen bonds with hydrogen peroxide and, as a result, stabilizing hydrogen peroxide within the dispersed phase composition (A) (or within droplets or particles formed therefrom).

[0013] In one example, the hydrogen peroxide stabilizer may be a substance having a functional group capable of hydrogen bonding with the hydrogen peroxide. The type of substance having a hydrogen bonding functional group is not particularly limited. For example, a substance having oxygen, nitrogen, or fluorine, etc., may be used as a hydrogen peroxide stabilizer.

[0014] In one example, the hydrogen peroxide stabilizer may include one or more selected from silica and silicic acid. In particular, when the manufactured particles are used in oral hygiene products, silica, which is a material usable as an abrasive or cleaning agent in the field of oral hygiene products, may be considered as a hydrogen peroxide stabilizer. In this case, the silica may include silanol groups on its surface.

[0015] In one example, the dispersed phase composition (A) may contain the hydrogen peroxide stabilizer in a range of 1 to 15 weight% based on 100 weight% of the total content of the dispersed phase composition. If the content of the hydrogen peroxide stabilizer is less than the above numerical range, the hydrogen peroxide may easily decompose before particle manufacturing because the hydrogen peroxide is not fixed. Furthermore, if the content of the hydrogen peroxide stabilizer exceeds the above numerical range, the hydrogen bonding between the hydrogen peroxide stabilizer and hydrogen peroxide becomes excessively strong, causing the dispersed phase solution to gel, and as a result, it is difficult for the dispersed phase dispersed within the continuous phase to form micro-sized particles. According to a specific embodiment, the lower limit of the content of the hydrogen peroxide stabilizer may be, for example, 1.5 wt% or more, 2.0 wt% or more, 2.5 wt% or more, 3.0 wt% or more, 3.5 wt% or more, 4.0 wt% or more, 4.5 wt% or more, or 5.0 wt% or more, and the upper limit may be, for example, 14.5 wt% or less, 14.0 wt% or less, 13.5 wt% or less, 13.0 wt% or less, 12.5 wt% or less, 12.0 wt% or less, 11.5 wt% or less, 11.0 wt% or less, 10.5 wt% or less, or 10 wt% or less.

[0016] The shellac mentioned above is a type of natural resin and is a substance widely used as a food additive, etc. In the process of mixing and stirring a dispersed phase composition (A) containing shellac with a continuous phase composition (B) while immersing droplets of the dispersed phase into the continuous phase, the shellac may solidify and form particles, and as a result, hydrogen peroxide may be contained within or fixed within the particles. The detailed process is described below.

[0017] In one example, the dispersed phase composition (A) may contain shellac in a range of 5 to 25 weight% based on 100 weight% of the total content of the dispersed phase composition. If the content of shellac is less than the above numerical range, it is difficult for the shellac to solidify on the particle surface side, which hinders the formation of micro-sized particles in the dispersed phase within the continuous phase. In addition, if the content of shellac exceeds the above numerical range, the shellac precipitates within the dispersed phase, and as a result, it is difficult for the dispersed phase dispersed within the continuous phase to form micro-sized particles. According to a specific embodiment, the lower limit of the content of shellac may be, for example, 6 weight% or more, 7 weight% or more, 8 weight% or more, 9 weight% or more, or 10 weight% or more, and the upper limit of the content may be, for example, 20 weight% or less or 15 weight% or less.

[0018] In one example, the solvent (S) included in the dispersed phase composition (A) A ) may be water or may contain it. That is, the dispersed phase may be an aqueous solution.

[0019] In one example, the solvent (S A ) may be deionized water or may contain it. If there are metal ions remaining in the aqueous solvent, hydrogen peroxide may be decomposed in the dispersed phase solution by said metal ions, or it may be difficult to form micrometer-sized dispersed phase particles in the continuous phase due to physical crosslinking between the hydrogen peroxide stabilizer (e.g., silicate) and the metal ions and the resulting gelation. The use of deionized water can prevent such problems.

[0020] In one example, the dispersed phase composition (A) is, based on 100 weight% of the total content of the dispersed phase composition, the solvent (S AIt may contain ) in a range of 20 to 95 weight%. When the above content range is satisfied, the dispersed phase may have a stable dispersion state within the continuous phase. Specifically, the solvent (S A The lower limit of the content of ) may be, for example, 30 wt% or more, 35 wt% or more, 40 wt% or more, 45 wt% or more, 50 wt% or more, 55 wt% or more, 60 wt% or more, 65 wt% or more, or 70 wt% or more, and the upper limit may be, for example, 90 wt% or less, 85 wt% or less, 80 wt% or less, or 75 wt% or less.

[0021] In one example, the dispersed phase composition (A) comprises hydrogen peroxide, a hydrogen peroxide stabilizer, and shellac as a solvent (S A It may be prepared by dissolving in ). The description regarding the characteristics or content of these components used for the formation of the dispersed phase is as described above.

[0022] In one example, the continuous phase composition (B) is a solvent (S B It may include ) and an ionic crosslinking agent. Solvent (S B In the case of ), the solvent (S described above) A It can be selected from those that do not hinder the formation of the dispersed phase and the continuous phase, respectively, in relation to ), and have sufficient compatibility with the ionic crosslinking agent.

[0023] In one example, the solvent (S BThe substance may be an alcohol or may contain alcohol. Alcohol is advantageous for sufficiently dissolving the ionic crosslinking agent material described below, thereby ensuring that the ionic crosslinking agent is sufficiently uniformly dispersed within the continuous phase. Consequently, the use of alcohol is advantageous for shellac solidification and hydrogen peroxide fixation through crosslinking between the ionic crosslinking agent and shellac. When alcohol (solvent of the continuous phase) and water (solvent of the dispersed phase) are simply mixed, droplets are not formed due to their incompatibility; however, when shellac and the ionic crosslinking agent exist separately in the dispersed phase and the continuous phase, respectively, and the two phases are mixed, crosslinking occurs through the ionic crosslinking agent, allowing solid particles to be formed within the continuous phase.

[0024] The type of alcohol used in the continuous phase composition (B) is not particularly limited. For example, ethanol may be used.

[0025] In one example, the continuous phase composition (B) is, based on 100 weight% of the total content of the continuous phase composition, the solvent (S B It may contain ) in a range of 50 to 95 weight%. Considering each component of the dispersed phase and the continuous phase and their functions, the solvent (S B A stable dispersed phase droplet can be formed within the content range of ). Specifically, the solvent (S B The lower limit of the content of ) may be, for example, 60 wt% or more, 65 wt% or more, 70 wt% or more, 75 wt% or more, 80 wt% or more, or 85 wt% or more, and the upper limit may be, for example, 94 wt% or less, 93 wt% or less, 92 wt% or less, 91 wt% or less, or 90 wt% or less.

[0026] The ionic crosslinking agent included in the continuous phase composition (B) may be a material capable of crosslinking with shellac included in the dispersed phase composition (A). For example, the ionic crosslinking agent may be a material capable of containing or providing calcium or calcium ions. Such an ionic crosslinking agent can enable secondary stabilization of hydrogen peroxide by providing crosslinking between shellac and calcium ions. Specifically, the ionic crosslinking agent may include one or more of calcium chloride (CaCl2), calcium carbonate (CaCO3), and calcium sulfate (CaSO4).

[0027] In one example, the continuous phase composition (B) may contain the ionic crosslinking agent in a range of 5 to 50 weight% based on 100 weight% of the total content of the continuous phase composition. When the content of the ionic crosslinking agent satisfies the above range, an appropriate level of ionic crosslinking occurs between shellac and the ionic crosslinking agent on the surface of the dispersed phase droplet, causing solidification of the dispersed phase droplet, and consequently, particles according to the present application can be obtained. Specifically, the upper limit of the ionic crosslinking agent content may be, for example, 40 weight% or less, 30 weight% or less, or 20 weight% or less.

[0028] In one example, the continuous phase composition (B) is an ionic crosslinking agent in a solvent (S B It may be manufactured by dissolving in ). The description regarding the characteristics or content of these components used for continuous phase formation is as described above.

[0029] In one example, the method may further include the step of mixing the dispersed phase composition (A) and the continuous phase composition (B). Specifically, the method comprises hydrogen peroxide, a hydrogen peroxide stabilizer, and shellac as a solvent (S A A dispersed phase composition (A) prepared by mixing in ); and a solvent (S BThe method may include a step of mixing a continuous phase composition (B) prepared by dissolving an ionic crosslinking agent in the ). If the components of the continuous phase or the dispersed phase are different from those above, particles according to the present application cannot be formed due to gelation between the mixed components as described below.

[0030] In one example, the method may include the step of mixing and stirring the dispersed phase composition (A) and the continuous phase composition (B). Through such stirring, droplets of the dispersed phase can be more stably settled and dispersed within the continuous phase. Specifically, the method comprises hydrogen peroxide, a hydrogen peroxide stabilizer, and shellac as a solvent (S A A dispersed phase composition (A) prepared by mixing in ); and a solvent (S B It may include a step of mixing and stirring a continuous phase composition (B) prepared by dissolving an ionic crosslinking agent in )

[0031] The method of mixing the dispersed phase composition (A) and the continuous phase composition (B) is not particularly limited. For example, a method of dispersing a small amount of the dispersed phase composition (A) into the continuous phase composition (B) may be used. Assuming that it does not hinder the formation of micro-sized particles, any known device used for the input may be used without limitation. The amount and speed of the dispersed phase being input can be appropriately performed by taking into account the size of the particles to be obtained and the components (dispersed phase, continuous phase, and their constituent components) and their content used.

[0032] In one example, the mixing of the dispersed phase composition (A) and the continuous phase composition (B) may be achieved by dispensing the dispersed phase composition (A) into the continuous phase composition (B) using an encapsulator. When the dispersed phase is introduced into the continuous phase using a dropper, pipette, or syringe, it is difficult to form particles of micrometer size, such as when the droplet size of the dispersed phase is in the mm range. On the other hand, the encapsulator device is advantageous for forming micrometer-sized particles by controlling the spray nozzle size, discharge speed, and frequency. The droplet size or introduction speed of the dispersed phase composition introduced (or discharged) into the continuous phase composition for the production of micrometer-sized particles can be appropriately controlled by a person skilled in the art using the encapsulator.

[0033] In one example, stirring of the mixture may be performed at a temperature of 1 to 10 ℃ and a speed of 100 to 500 rpm.

[0034] In one example, the method may further include a step of drying the mixture of the dispersed phase and the continuous phase after stirring. Since hydrogen peroxide present inside the droplets or particles may decompose if the drying temperature is excessively high, the drying temperature must be appropriately controlled. For example, drying may be performed at a temperature higher than the stirring temperature, more specifically at room temperature (about 18 to 27°C).

[0035] Particles manufactured as described above provide improved hydrogen peroxide stability compared to conventional technology. For example, even if PVP stabilizes hydrogen peroxide in a paste product such as toothpaste, it was difficult to prevent the decomposition (loss) of hydrogen peroxide when hydrogen peroxide decomposition substances diffuse into the paste and the degree of exposure of hydrogen peroxide to the decomposition substances increases. However, in this application, hydrogen peroxide is double-stabilized using a hydrogen peroxide stabilizer and a shellac, so even if hydrogen peroxide is exposed to decomposition substances, the degree of decomposition or loss can be reduced compared to conventional technology. In this regard, particles manufactured by the above method can have excellent hydrogen peroxide holding capacity. For example, particles manufactured according to the method of this application can have a hydrogen peroxide content of 0.50% or more based on the weight of hydrogen peroxide included in the dispersed phase composition (A) (or used when manufacturing the dispersed phase composition (A)).

[0036] In addition, particles produced by the above method may have a size in the micrometer (μm) range. For example, the particles may have a size in the range of 10 to 900 μm. In this case, the particle size may refer to the length of the longest dimension among the shapes of the particles. According to a specific embodiment of the present application, the lower limit of the particle size may be, for example, 100 μm or more, 150 μm or more, 200 μm or more, 250 μm or more, or 300 μm or more, and the upper limit may be, for example, 800 μm or less, 700 μm or less, 600 μm or less, 500 μm or less, or 400 μm or less. In this way, when hydrogen peroxide is stabilized within the particles, it is possible to uniformly disperse the particles when mixed with other components, and concerns regarding the decomposition of some hydrogen peroxide expected during mixing can be resolved to some extent.

[0038] In another example relating to the present application, the present application relates to hydrogen peroxide-containing particles. The particles can be manufactured by the method described above.

[0039] The particle has an interior comprising hydrogen peroxide and a hydrogen peroxide stabilizer that stabilizes the hydrogen peroxide through hydrogen bonding; and a shell comprising shellac having ionic cross-linking. Depending on the drying temperature described above, the interior of the particle contains a solvent (S A )(e.g., water or ionized water) may also exist.

[0040] The above particles may have the size described above.

[0041] The shape or form of the above particles is not particularly limited, but considering the manufacturing method using a dispersed phase and a continuous phase, they may have a spherical or elliptical shape, for example.

[0042] The description regarding the composition or other characteristics of the above particles is the same as the description regarding the manufacturing method.

[0043] The use of the above particles is not particularly limited. In addition to oral hygiene products, they can be used anywhere hydrogen peroxide-containing particles are required for applications where the antibacterial and bleaching power of hydrogen peroxide is needed.

[0045] In another example relating to the present application, the present application relates to a composition comprising the hydrogen peroxide-containing particles. The use of the composition is not particularly limited and can be used anywhere hydrogen peroxide immobilization is required for applications where the antibacterial and bleaching power of hydrogen peroxide is required. Specifically, the use of the composition may be oral care products, such as toothpaste, or whitening products containing hydrogen peroxide-containing particles. Effects of the invention

[0046] According to the present application, a particle is provided that can first stabilize hydrogen peroxide internally and secondarily stably fix hydrogen peroxide through a shell. Specifically, the present application provides a particle that stabilizes hydrogen peroxide internally through hydrogen bonding with a stabilizer and further stably fixes hydrogen peroxide by a solidified shellac that forms the shell (outer shape) of the particle. Brief explanation of the drawing

[0047] FIG. 1 schematically illustrates the process of stabilizing and immobilizing hydrogen peroxide in particles according to the present application. Specific details for implementing the invention

[0048] The operation and effects of the present invention will be explained in more detail through the embodiments described below. However, since the embodiments are presented as examples of the invention, the scope of the invention is not limited in any way.

[0049] Examples and Comparative Examples

[0050] Example 1

[0051] An aqueous solution (A) was prepared by dissolving silica containing silanol groups on its surface, hydrogen peroxide (H2O2), and shellac in deionized water (DIW). Then, a solution (B) in which calcium chloride (CaCl2) was dissolved in ethanol was prepared, and the particles of the aqueous solution (A) were precipitated by extruding the aqueous solution (A) into the solution (B) using a buchi encapsulator at approximately 4°C. At this time, the nozzle size during extrusion was 120 μm, the frequency was 2,500 Hz, and the extrusion speed was 1.5 mL / min, and the distance between the nozzle and the solution (B) was 15 cm. The dispersed particles formed from the aqueous solution (A) were stabilized by stirring at 200 rpm for about 1 hour, and after filtering the dispersed particles through a 70 μm sieve, they were dried at room temperature. The specific content (weight%) of each component is as listed in Table 1.

[0052] Examples 2 to 5

[0053] Silicic acid was prepared by adding 10g of washed Amberlite IR-120 to 25 ml of 20% sodium silicate solution, mixing with DIW, and stirring at 300 rpm.

[0054] Particles were obtained by mixing the aqueous solution (A) and the solution (B) in the same manner as in Example 1, except that silicic acid was added to the aqueous solution (A) instead of silica. The specific content (weight%) of each component is as listed in Table 1.

[0055] Comparative Example 1

[0056] Aqueous solutions (A) and (B) were prepared in the same manner as in Example 1, except that an aqueous solution (A) was used in which silica containing silanol groups on the surface and hydrogen peroxide (H2O2) were dissolved in DI water (deionized water), and a solution (B) in which shellac was dissolved in ethanol was used. However, particles could not be obtained due to gelation of the aqueous solution (A). The specific content (weight%) of each component is as listed in Table 1.

[0057] Comparative Example 2

[0058] Silica containing silanol groups on its surface, hydrogen peroxide (H2O2), and shellac were dissolved in DI water (deionized water), and an aqueous solution was prepared by additionally adding calcium chloride (CaCl2). However, due to the gelation of the aqueous solution (A), droplets of the dispersed phase aqueous solution could not be ejected into the continuous phase. The specific content (weight%) of each component is as described in Table 1.

[0059] Comparative Example 3

[0060] Silicic acid was prepared by adding 10g of washed Amberlite IR-120 to 25 ml of a 20% sodium silicate solution, mixing with DIW, and stirring at 300 rpm. An aqueous solution (A) was prepared by dissolving the prepared silicic acid, hydrogen peroxide (H2O2), and calcium chloride (CaCl2) in DI water (deionized water). Then, the aqueous solution (A) was attempted to be precipitated in ethanol in which shellac was dissolved at a concentration of 10%, but droplets of the dispersed aqueous solution could not be ejected into the continuous phase due to the gelation of the aqueous solution (A). The specific content (weight%) of each component is as listed in Table 1.

[0061] Comparative Example 4

[0062] An aqueous solution (A) was prepared by dissolving silicic acid, hydrogen peroxide (H2O2), and shellac in DI water (deionized water). Then, the aqueous solution (A) was dropped into oil (liquid paraffin containing 1% span-80) using a micropipette and dispersed by stirring. After stirring for about 1 hour, calcium chloride (CaCl2) was added to the liquid paraffin. The specific content (weight%) of each component is as listed in Table 1.

[0063] Evaluation and Measurement Items

[0064] Regarding the particles of the examples and comparative examples, evaluations and measurements were performed as follows and are listed in Table 2.

[0065] (1) Whether microparticle formation is possible

[0066] O : Particle formation occurs

[0067] X: Particle formation does not occur

[0068] (2) Analysis of hydrogen peroxide content of particles

[0069] Hydrogen peroxide is Pierce TM The content was analyzed using a Quantitative Peroxide Assay kit (Thermo Scientific). The specific procedure is as follows.

[0070] 1) The color change from the Fe-xylenol orange complex (reaction time 20 min) according to the hydrogen peroxide content is read at 595 nm using a microplate reader.

[0071] 2) Prepare a standard curve based on absorbance data according to hydrogen peroxide content.

[0072] 3) The particles prepared in the examples and comparative examples, respectively, are dispersed in DI water at a concentration of 0.1 to 2 mg / ml, and the sample supernatant is mixed with Assay kit reagent in a volume ratio of 1:10.

[0073] 4) The mixture obtained in 3) is reacted at room temperature for 20 minutes, and the absorbance is measured at 595 nm. The measured absorbance value is substituted into the standard curve in 2) to calculate the hydrogen peroxide content.

[0074] (3) Particle size

[0075] The particle size was confirmed and measured using an optical microscope (Olympus).

[0076] Dispersed phase Continuous image DI water solvent 1) Ethanol solvent 2) Liquid paraffin solvent 3) silica Silicate hydrogen peroxide Shellac calcium chloride calcium chloride Shellac calcium chloride Example 1 10 - 37 6 - 10 - Non-use Example 2 - 5 12 12 - 10 - Non-use Example 3 - 4 25 7 - 10 - Non-use Example 4 - 5 22 7 - 10 - Non-use Example 5 - 4 22 9 - 10 - Non-use Comparative Example 1 10 - 50 - - - 24 Non-use Comparative Example 2 10 - 40 10 10 Non-use Comparative Example 3 - 4.5 27 - 11.3 - 10 Non-use Comparative Example 4 - 5 12 12 - Non-use 4 Unit: Weight % Content Basis: 100 weight% of dispersed phase or 100 weight% of continuous phase 1), 2), and 3): The remaining weight % excluding the content of components other than the solvent, out of 100 weight% of the dispersed phase composition, continuous phase composition, or mixture used in each example and comparative example.

[0077] hydrogen peroxide content of particles Whether or not it is microparticle particle size Example 1 0.50 % O Within the range of 170 - 320 μm Example 2 0.40 % O Within the range of 170 - 320 μm Example 3 1.23 % O Within the range of 170 - 320 μm Example 4 2.26 % O Within the range of 170 - 320 μm Example 5 1.90 % O Within the range of 170 - 320 μm Comparative Example 1 - X (Cannot form particles due to gelation between silica and hydrogen peroxide) - Comparative Example 2 - X (Cannot form into particles due to gelation of the mixture) - Comparative Example 3 - X (Cannot form into particles due to gelation of the aqueous solution) - Comparative Example 4 - X (After adding calcium chloride, white foam decomposition products were generated, making granulation impossible) -

Claims

Claim 1 The method comprises the step of mixing a dispersed phase composition (A), prepared by dissolving hydrogen peroxide, a hydrogen peroxide stabilizer, and shellac in a solvent (SA), with a continuous phase composition (B), prepared by dissolving an ionic crosslinking agent in a solvent (SB), to form droplets of the dispersed phase composition (A) within the continuous phase composition (B); the mixing of the dispersed phase composition (A) and the continuous phase composition (B) is performed by extruding the dispersed phase composition (A) into the continuous phase composition (B) using an encapsulator; based on the total content of the dispersed phase composition, the dispersed phase composition (A) contains 5 to 15 weight% of shellac; based on the total content of the dispersed phase composition, the dispersed phase composition (A) contains 15 weight% or more and 37 weight% or less of hydrogen peroxide and 1 to 15 weight% of a hydrogen peroxide stabilizer; and based on the total content of the continuous phase composition, the continuous phase composition (B) contains the ionic crosslinking agent A method for manufacturing hydrogen peroxide-containing particles, comprising in a range of 5 to 50 weight% and having a size in the range of 10 to 500 μm. Claim 2 A method for manufacturing hydrogen peroxide-containing particles according to claim 1, wherein the hydrogen peroxide stabilizer is a substance having a functional group capable of hydrogen bonding with the hydrogen peroxide. Claim 3 A method for manufacturing hydrogen peroxide-containing particles according to claim 1, wherein the hydrogen peroxide stabilizer comprises one or more selected from silica and silicic acid. Claim 4 delete Claim 5 delete Claim 6 In claim 1, the solvent (S A ) is a method for manufacturing hydrogen peroxide-containing particles containing water. Claim 7 delete Claim 8 delete Claim 9 In claim 1, the solvent (S B ) is a method for manufacturing hydrogen peroxide-containing particles containing alcohol. Claim 10 A method for manufacturing hydrogen peroxide-containing particles according to claim 1, wherein the ion crosslinking agent comprises a substance containing or providing calcium ions. Claim 11 A method for manufacturing hydrogen peroxide-containing particles according to claim 1, wherein the ionic crosslinking agent comprises one or more of calcium chloride (CaCl2), calcium carbonate (CaCO3), and calcium sulfate (CaSO4). Claim 12 delete Claim 13 delete Claim 14 A method for manufacturing hydrogen peroxide-containing particles according to claim 1, wherein, based on the weight of hydrogen peroxide included in the dispersed phase composition (A), the hydrogen peroxide-containing particles have a hydrogen peroxide content of 0.50% or more. Claim 15 delete Claim 16 A hydrogen peroxide-containing particle produced by the method of claim 1, having an interior comprising hydrogen peroxide and a hydrogen peroxide stabilizer that stabilizes the hydrogen peroxide through hydrogen bonding; and a shell comprising shellac having ionic cross-linking, and having a size in the range of 10 to 500 μm. Claim 17 A composition comprising particles according to claim 16.

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