Two-layer composition for mouthwash

Abstract

The present invention relates to a two-layer oral rinse composition, and more specifically, comprises a two-layer structure consisting of an aqueous layer and an oil layer located on top of the aqueous layer, wherein the aqueous layer contains a fluoride component and xylitol, and the oil layer contains one or more of jojoba oil, mastic oil, olive oil, eucalyptus oil, corn mint oil, spearmint oil, peppermint oil, peppermint oil, lemon oil, orange oil, tea tree oil, coconut oil, and sunflower oil. According to the present invention, there is an advantage of more effectively improving oral health by inhibiting the proliferation of bacteria in the oral cavity and preventing the occurrence of oral diseases, while simultaneously providing moisture to the mouth to prevent oral dryness.

Description

Technology Field

[0001] The present invention relates to a two-layer mouthwash composition, and more specifically, to a two-layer mouthwash composition composed of an aqueous layer and an oil layer, which provides excellent oral hygiene as well as a preventive effect against oral dryness. Background Technology

[0003] Unlike other tissues in the human body, teeth cannot be restored to their original state once damaged. Furthermore, severe dental caries or periodontal disease can release inflammatory substances into the bloodstream, potentially affecting conditions such as diabetes, pneumonia, dementia, and cardiovascular disease.

[0004] South Korea has the highest rate of low birth rate and aging among the 37 OECD countries worldwide. As the elderly suffer from systemic diseases such as hypertension, diabetes, and dementia, oral tissues deteriorate, leading to oral diseases such as dry mouth and cavities caused by reduced saliva secretion.

[0005] However, 80 to 90 percent of these oral diseases can be prevented through proper oral care in daily life. The foundation of oral care is brushing teeth. In addition, mouthwash is used to supplement oral hygiene that is insufficient with brushing only toothpaste.

[0006] Mouthwash has the advantage of removing oral bacteria, such as cavities and gum bacteria, that have taken over not only the surface of the teeth but also the gums, tongue, and other parts of the mouth, and it can effectively penetrate even areas that are difficult to brush to eliminate oral bacteria.

[0007] However, since mouthwash contains ethanol, the evaporation of this ethanol also draws out moisture, causing the mouth to become dry. In particular, elderly people over the age of 65, those taking medication for high blood pressure, and those with xerostomia have reduced saliva production, which protects the oral mucosa; therefore, using mouthwash containing ethanol can exacerbate this dry mouth condition.

[0008] Due to these issues, oil pulling, an oral hygiene method utilizing oil, has recently been used. Oil pulling is effective in removing oral bacteria, alleviating inflammation, and keeping the mouth moist by using oil in the mouth.

[0009] However, because it uses a high concentration of oil, it causes a lot of aversion during use, and in particular, the taste of the oil makes it unpleasant to use. Additionally, it has the disadvantage of being ineffective in preventing cavities because it does not contain cavity-preventing ingredients. Prior art literature

[0011] (Patent Document 0001) KR 10-2123327 B1 The problem to be solved

[0012] Accordingly, the objective of the present invention is to provide a two-layer mouthwash composition that is composed of an aqueous layer and an oil layer, thereby preventing oral dryness and providing a moisturizing effect through the oil layer, preventing tooth decay and gum disease, removing plaque, and eliminating bad breath through the aqueous layer, and furthermore effectively preventing oral diseases due to the interaction between the aqueous layer and the oil layer. means of solving the problem

[0014] The oral rinse composition of the present invention for achieving the above-mentioned purpose is composed of a two-layer structure comprising an aqueous layer and an oil layer located on top of the aqueous layer, wherein the aqueous layer comprises a fluoride component and xylitol, and the oil layer comprises one or more of jojoba oil, mastic oil, olive oil, eucalyptus oil, corn mint oil, spearmint oil, peppermint oil, peppermint oil, lemon oil, orange oil, tea tree oil, coconut oil, and sunflower oil.

[0015] The fluorine component of the above aqueous layer is characterized as being one or more of sodium fluoride, sodium monofluorophosphate, and fluoride.

[0016] The above oil layer is characterized by comprising jojoba oil, mastic oil, olive oil, tea tree oil, coconut oil, and sunflower oil.

[0017] Based on 100% by weight of the above mouthwash composition, it is characterized by being composed of 50-99.9% by weight of the aqueous layer and 0.01-50% by weight of the oil layer.

[0018] It is characterized by being composed of 75% by weight of the aqueous layer and 25% by weight of the oil layer.

[0019] The above aqueous layer is characterized by further comprising one or more selected from the group consisting of sorbitol, erythritol, steviol glycosides, enzyme-treated stevia, glycerin, sodium benzoate, methyl parahydroxybenzoate, sodium bicarbonate, cetylpyridinium chloride, sodium pyrophosphate, ethanol, sodium saccharin, water-soluble fragrance, floroxamer 407, polyoxyethylene hydrogenated castor oil, and hyaluronic acid. Effects of the invention

[0021] According to the present invention, there is an advantage of more effectively improving oral health by inhibiting the proliferation of bacteria in the oral cavity and preventing the occurrence of oral diseases, while simultaneously providing moisture to the mouth to prevent oral dryness.

[0022] In addition, it has the advantage of enabling more convenient and effective oral health care through the interaction of the separated water layer and oil layer, enhancing the convenience of users' lives, and contributing to improving the quality of daily life. Brief explanation of the drawing

[0024] FIG. 1 is a photograph of Examples 1 to 3 according to the present invention. Specific details for implementing the invention

[0025] The present invention will be described in more detail below.

[0026] The most significant feature of the present invention is that, unlike conventional mouthwashes, it is composed of a two-layer structure of an aqueous layer and an oil layer, which not only more effectively inhibits the proliferation of bacteria in the oral cavity but also prevents oral dryness by providing moisture to the mouth, thereby improving the user's oral health.

[0028] The oral rinse composition of the present invention is composed of two layers: an aqueous layer and an oil layer located on top of the aqueous layer; wherein the aqueous layer comprises a fluoride component and xylitol, and the oil layer comprises one or more of jojoba oil, mastic oil, olive oil, eucalyptus oil, corn mint oil, spearmint oil, peppermint oil, peppermint oil, lemon oil, orange oil, tea tree oil, coconut oil, and sunflower oil.

[0030] First, the above-mentioned aqueous layer will be explained.

[0031] The above aqueous layer inhibits bacterial growth to prevent tooth decay, eliminates bad breath, and helps alleviate inflammation, thereby preventing the occurrence of oral diseases. It also removes plaque. This aqueous layer contains fluoride and xylitol.

[0032] The above fluoride component is one or more of sodium fluoride, sodium monofluorophosphate, and fluoride, which prevents tooth decay by supplying fluoride and strengthens teeth by promoting calcium supply. The above fluoride component may be included in a range of 0.01 to 0.05 weight% based on 100 weight% of the total mouthwash composition, because if the above fluoride component is less than 0.01 weight%, it cannot provide a sufficient effect of preventing tooth decay, and if it exceeds 0.05 weight%, it becomes an excess amount, and the fluoride content becomes higher than necessary.

[0033] The above xylitol is a sweetener that not only improves the refreshing sensation but also prevents tooth decay and eliminates bad breath. The above xylitol may be included in an amount of 0.01 to 2 weight percent based on 100 weight percent of the total mouthwash composition, because if it is less than 0.01 weight percent, the effect is negligible, and even if it exceeds 2 weight percent, it cannot show any further enhanced effect.

[0034] In addition, the aqueous layer may further include one or more selected from the group consisting of sorbitol, erythritol, steviol glycosides, enzyme-treated stevia, glycerin, sodium benzoate, methyl parahydroxybenzoate, sodium bicarbonate, cetylpyridinium chloride, sodium pyrophosphate, ethanol, sodium saccharin, water-soluble fragrance, floroxamer 407, polyoxyethylene hydrogenated castor oil, and hyaluronic acid.

[0035] The above sorbitol and erythritol are sugar alcohols that have excellent cavity prevention effects and serve to improve the user experience by having a sweet taste. Based on 100% by weight of the total mouthwash composition, the above sorbitol may be included in an amount of 5 to 12% by weight and the above erythritol may be included in an amount of 0.1 to 1.5% by weight, but this is not limited thereto.

[0036] The above-mentioned steviol glycosides and enzyme-treated stevia are used as sweeteners, and based on 100% by weight of the total mouthwash composition, the steviol glycosides may be included in an amount of 0.5 to 1.5% by weight and the enzyme-treated stevia in an amount of 0.5 to 1.5% by weight, but this is not limited thereto.

[0037] The above glycerin is used as a humectant and may be included in an amount of 1 to 8 weight percent based on 100 weight percent of the total mouthwash composition, but is not limited thereto.

[0038] The above sodium benzoate and methyl parahydroxybenzoate are used as preservatives, and based on 100% by weight of the total mouthwash composition, the sodium benzoate and methyl parahydroxybenzoate may be included in an amount of 0.1 to 0.5% by weight, but are not limited thereto.

[0039] The sodium bicarbonate above relieves gum inflammation, eliminates bad breath, and provides a whitening effect. Based on 100% by weight of the total mouthwash composition, the sodium bicarbonate may be included in an amount of 0.01 to 3% by weight, but is not limited thereto.

[0040] The above cetylpyridinium chloride inhibits the growth of bacteria in the oral cavity, eliminates bad breath, reduces plaque formation, and prevents gum disease. Based on 100% by weight of the total mouthwash composition, the cetylpyridinium chloride may be included in an amount of 0.01 to 0.1% by weight; however, since excessive use of this can cause dryness in the oral cavity, it should not be included in excessive amounts.

[0041] The sodium pyrophosphate above removes plaque. Based on 100% by weight of the total mouthwash composition, the sodium pyrophosphate may be included in an amount of 0.01 to 0.2% by weight, but is not limited thereto.

[0042] The above ethanol removes bacteria in the oral cavity and can be added as needed. The above ethanol may be included in an amount of 10 to 30 weight percent based on 100 weight percent of the total mouthwash composition, but excessive use of it causes dryness in the oral cavity, so it should not be included in excessive amounts.

[0043] The above-mentioned sodium saccharin and water-soluble flavoring enhance palatability and are included in the range of 0.01 to 0.2 weight% of sodium saccharin and 0.01 to 0.1 weight% of water-soluble flavoring, based on 100 weight% of the total mouthwash composition.

[0044] The above-mentioned floroxamer 407 and polyoxyethylene hydrogenated castor oil are ingredients commonly used in mouthwash compositions, and are included in an amount of 0.1 to 1 weight% of floroxamer 407 and 0.5 to 1.5 weight% of polyoxyethylene hydrogenated castor oil based on 100 weight% of the total mouthwash composition. However, excessive use of these ingredients makes it difficult to form a bilayer, so excessive use is avoided.

[0045] The above hyaluronic acid enhances the delivery and residual effect of the active ingredient within the oral cavity, effectively inhibiting plaque formation and inhibiting the occurrence of gum disease and tartar formation. Based on 100% by weight of the total mouthwash composition, the above hyaluronic acid may be included in an amount of 0.01 to 0.5% by weight, but is not limited thereto.

[0046] In addition, it is natural that purified water is used as the solvent for the aqueous phase, and it is natural that the said purified water is included in an amount equal to the remainder of the components excluding the purified water in the aqueous phase and the total components of the oil phase.

[0048] In addition, the oil layer located on top of the above aqueous layer provides moisture to the mouth and prevents oral dryness, thereby playing a role in more effectively improving oral health. This oil layer includes one or more of jojoba oil, mastic oil, olive oil, eucalyptus oil, corn mint oil, spearmint oil, peppermint oil, peppermint oil, lemon oil, orange oil, tea tree oil, coconut oil, and sunflower oil.

[0049] These oil components have anti-inflammatory and antibacterial properties, which not only prevent gum disease but also have excellent effects in eliminating bad breath and preventing oral dryness by providing moisture. More preferably, the oil layer comprises jojoba oil, mastic oil, olive oil, tea tree oil, coconut oil, and sunflower oil.

[0050] In addition, the mouthwash composition of the present invention preferably comprises 50 to 99.9% by weight of the aqueous layer and 0.01 to 50% by weight of the oil layer, based on 100% by weight of the total. This is in consideration of effects such as preventing tooth decay, preventing gum disease, removing bad breath, and preventing dry mouth. This is because if the content of the oil layer is too low, dry mouth cannot be prevented, and if it is excessive, the effects of preventing tooth decay and gum disease may be relatively reduced. Considering these effects, it is most preferably composed of 75% by weight of the aqueous layer and 25% by weight of the oil layer.

[0052] The mouthwash composition of the present invention, configured as described above, is composed of an aqueous layer and an oil layer as previously explained, and has the advantage of more effectively improving oral health by inhibiting the proliferation of bacteria in the oral cavity and preventing the occurrence of oral diseases, while simultaneously providing moisture to the mouth to prevent oral dryness.

[0054] The present invention will be explained in more detail below through examples.

[0055] (Examples 1 to 3)

[0056] Mouthwash compositions of Examples 1 to 3 were prepared with the compositions shown in Table 1 below. Figure 1 is a photograph of Examples 1 to 3.

[0057] Composition ratios of Examples 1 to 3 Ingredient name Example 1 Example 2 Example 3 Sodium fluoride 0.02 0.05 0.05 xylitol 1 1 1 Cetylpyridinium chloride 0.05 - - Sorbitol 10 - - Sodium saccharin 0.1 0.1 0.1 Erythritol 1 1 1 Steviol glycosides 1 1 1 Enzyme-treated stevia 1 1 1 Floxamer 407 0.5 0.5 0.5 Hardened castor oil 1 1 1 Hyaluronic acid 0.1 0.1 0.1 glycerin 5 5 5 Sodium benzoate 0.3 0.3 0.3 methyl parahydroxybenzoate 0.2 - - sodium pyrophosphate 0.1 0.1 0.1 Jojoba 5 3 10 mastic oil 0.1 3 3 olive oil 0.1 3 3 Tea tree oil 0.1 3 3 coconut oil 0.1 3 3 sunflower oil 1 3 3 purified water To 100 To 100 To 100

[0059] (Comparative Examples 1 to 3)

[0060] Oral rinse compositions of Comparative Examples 1 to 3 were prepared with the compositions shown in Table 2 below.

[0061] Composition ratios of Comparative Examples 1 to 3 Ingredient name Comparative Example 1 Comparative Example 2 Comparative Example 3 Sodium fluoride 0.05 0.02 - Cetylpyridinium chloride 0.05 0.05 0.05 xylitol 1 1 1 Sorbitol 10 10 10 Sodium saccharin 0.1 0.1 0.1 Erythritol 1 1 1 Steviol glycosides 1 1 1 Enzyme-treated stevia 1 1 1 Floxamer 407 0.5 0.5 0.5 Hardened castor oil 1 1 1 Hyaluronic acid 0.1 0.1 0.1 ethanol 15 20 30 glycerin 5 5 5 Sodium benzoate 0.3 0.3 0.3 methyl parahydroxybenzoate 0.2 0.2 0.2 sodium pyrophosphate 0.1 0.1 0.1 purified water To 100 To 100 To 100

[0063] (Test Example 1)

[0064] The above examples and comparative examples were provided to 20 subjects, and after gargling, moisturizing satisfaction, moisturizing duration, improvement in oral dryness, improvement in tooth sensitivity, and overall satisfaction were evaluated on a scale of 100%, and the average values ​​are shown in Table 3 below.

[0065] Test Example 1 Result (%) division Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 Moisturizing satisfaction 30.3 25.6 22.1 78.3 88.5 90.5 Long-lasting moisturization 23.5 35.5 48.5 63.5 72.5 88.6 Improvement of dry mouth 12.5 32.5 40.2 68.8 75.5 86.3 Improvement of tooth sensitivity 52.1 56.5 60.2 75.5 82.4 90.5 Overall satisfaction 45.5 55.5 58.6 85.4 90.2 92.2

[0066] As can be seen in Table 3 above, it was confirmed that Examples 1 to 3 of the present invention received higher ratings in moisturization satisfaction, moisturization duration, improvement in oral dryness, improvement in tooth sensitivity, and overall satisfaction compared to Comparative Examples 1 to 3.

[0068] (Test Example 2)

[0069] The above examples and comparative examples were provided to 20 test subjects, and after gargling, the satisfaction with bad breath reduction was evaluated on a scale of 100%, and the average value is shown in Table 4 below.

[0070] Test Example 2 Result (%) division Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 reduction of bad breath 75.3 78.5 82.5 88.5 91.6 95.6

[0071] As shown in Table 4 above, it was confirmed that Examples 1 to 3 of the present invention received a higher rating in terms of satisfaction with bad breath reduction compared to Comparative Examples 1 to 3.

[0073] (Test Example 3)

[0074] The bactericidal effect against Streptococcus mutans, known as the causative agent of tooth decay, was tested. Initial bacterial count 10 5 Comparative examples and examples were each treated at CFU / mL levels, and the sterilization power was confirmed after 60 seconds. The results are shown in Table 5 below.

[0075] Bactericidal effect (%) against S. mutans division Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 Sterilizing power 77.5 80.2 86.5 99.9 99.9 99.9

[0076] As shown in Table 5 above, it was confirmed that Examples 1 to 3 of the present invention all have excellent bactericidal power against S. mutans.

[0078] (Test Example 4)

[0079] Purified water (Control), examples, and comparative examples were provided to 20 subjects, and the plaque removal effect before and after gargling was evaluated. The results are shown in Table 6 below. The degree of plaque removal was visually evaluated through plaque staining, and the results were evaluated using an index of 1 to 10 based on 5 for purified water. For each index, the higher the number, the better the plaque removal effect.

[0080] Test Example 4 Results division Comparative Example 1 Comparative Example 2 Comparative Example 3 Example 1 Example 2 Example 3 Plaque removal 6 6 5 8 8 9

[0081] As shown in Table 6 above, it was confirmed that Examples 1 to 3 of the present invention received a higher evaluation in plaque removal compared to Comparative Examples 1 to 3.

[0083] (Test Example 5)

[0084] A 250ml transparent plastic container was prepared, and the bad breath-causing components Methlmercaptan, Methylamine, and Ammonium hydroxide were placed in each container. After sealing the container with a lid equipped with a detector tube, the initial values ​​were set to 130±5ppm for Methlmercaptan, 90±2ppm for Methylamine, and 190±5ppm for Ammonium hydroxide.

[0085] The test groups were divided, and the compositions of the examples and comparative examples were each placed into 250ml transparent plastic containers. Then, a bad breath-inducing ingredient was added to the container, the lid equipped with a detector tube was closed and sealed, and after curing for 30 minutes, the value measured by a GASTEC gas detector was used as the final value and compared with the initial value above. The measurement results are shown in Table 7 below.

[0086] Test Example 5 Results division Measurement of inhibition of bad breath-causing components (ppm) Methlmercaptan Methylamine Ammonium hydroxide blank 128 91 189 Comparative Example 1 98 82 135 Comparative Example 2 91 74 121 Comparative Example 3 89 81 115 Example 1 70 56 77 Example 2 53 42 73 Example 3 50 37 62

[0087] As shown in Table 7 above, it was confirmed that Examples 1 to 3 of the present invention have a superior effect in inhibiting bad breath-causing components compared to Comparative Examples 1 to 3.

[0089] (Examples 4 to 6)

[0090] The mouthwash compositions of Examples 4 to 6 were prepared with the following compositions.

[0091] Composition ratios of Examples 4 to 6 Ingredient name Example 4 Example 5 Example 6 Sodium fluoride 0.05 0.05 0.05 xylitol 1 1 1 Jojoba 5 3 18 mastic oil 0.1 3 - olive oil 0.1 3 - Tea tree oil 0.1 3 - coconut oil 0.1 3 - sunflower oil 1 3 - purified water To 100 To 100 To 100

[0093] (Comparative Examples 4 to 6)

[0094] The mouthwash compositions of Comparative Examples 4 to 6 were prepared with the following compositions.

[0095] Composition ratios of Comparative Examples 4 to 6 Ingredient name Comparative Example 4 Comparative Example 5 Comparative Example 6 Jojoba 5 3 18 mastic oil 0.1 3 - olive oil 0.1 3 - Tea tree oil 0.1 3 - coconut oil 0.1 3 - sunflower oil 1 3 - purified water To 100 To 100 To 100

[0097] (Test Example 6)

[0098] The above examples and comparative examples were provided to 20 subjects, and after gargling, moisturizing satisfaction, moisturizing duration, improvement in oral dryness, improvement in tooth sensitivity, and overall satisfaction were evaluated on a scale of 100%, and the average values ​​are shown in Table 10 below.

[0099] Test Example 3 Result (%) division Comparative Example 4 Comparative Example 5 Comparative Example 6 Example 4 Example 5 Example 6 Moisturizing satisfaction 70.2 72.1 67.8 78.5 87.0 85.1 Long-lasting moisturization 59.4 63.1 60.5 62.3 70.4 68.5 Improvement of dry mouth 65.1 66.2 61.7 67.1 73.2 70.8 Improvement of tooth sensitivity 70.1 71.3 69.5 74.6 81.2 75.9 Overall satisfaction 79.9 83.3 78.2 85.9 89.8 85.7

[0100] As can be seen in Table 10 above, it was confirmed that Examples 4 to 6 of the present invention received higher ratings in moisturization satisfaction, moisturization duration, improvement in oral dryness, improvement in tooth sensitivity, and overall satisfaction compared to Comparative Examples 4 to 6. In addition, the satisfaction of Example 5, which used a mixture of six types of oils, was higher than that of Example 6, which used a single oil.

[0102] (Test Example 7)

[0103] The above examples and comparative examples were provided to 20 test subjects, and after gargling, the satisfaction with bad breath reduction was evaluated on a scale of 100%, and the average value is shown in Table 11 below.

[0104] Test Example 7 Result (%) division Comparative Example 4 Comparative Example 5 Comparative Example 6 Example 4 Example 5 Example 6 reduction of bad breath 41.2 45.9 40.3 85.1 89.8 80.1

[0105] As shown in Table 11 above, it was confirmed that Examples 4 to 6 of the present invention received a higher rating in terms of satisfaction with bad breath reduction compared to Comparative Examples 4 to 6.

[0107] Although preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements by those skilled in the art using the basic concept of the present invention as defined in the following claims also fall within the scope of the present invention.

Claims

Claim 1 A two-layer mouthwash composition comprising: an aqueous layer; and an oil layer located above the aqueous layer; wherein the aqueous layer comprises a fluoride component and xylitol, and the oil layer comprises jojoba oil, mastic oil, olive oil, tea tree oil, coconut oil, and sunflower oil, and wherein, based on 100% by weight of the mouthwash composition, the aqueous layer comprises 50 to 99.9% by weight and the oil layer comprises 0.1 to 50% by weight, thereby providing a cavity prevention effect by the aqueous layer and a mouth dryness prevention effect by the oil layer. Claim 2 A two-layer oral rinse composition according to claim 1, characterized in that the fluorine component of the aqueous layer is one or more of sodium fluoride, sodium monofluorophosphate, and fluorite. Claim 3 delete Claim 4 delete Claim 5 A two-layer oral rinse composition according to claim 1, characterized by being composed of 75% by weight of an aqueous layer and 25% by weight of an oil layer. Claim 6 A bilayer oral rinse composition according to claim 1, characterized in that the aqueous layer further comprises one or more selected from the group consisting of sorbitol, erythritol, steviol glycoside, enzyme-treated stevia, glycerin, sodium benzoate, methyl parahydroxybenzoate, sodium bicarbonate, cetylpyridinium chloride, sodium pyrophosphate, ethanol, sodium saccharin, water-soluble fragrance, floroxamer 407, polyoxyethylene hydrogenated castor oil, and hyaluronic acid.

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