Preservative composition and cosmetic composition with the same

Abstract

A preservative composition is provided according to an embodiment of the present application. The preservative composition may include propylene glycol caprylate and glyceryl caprylate.

Description

Technology Field

[0001] The present application relates to a preservative composition and a cosmetic composition containing the same. Background Technology

[0002] Chemical preservatives such as 1,2-hexanediol are widely used in cosmetic compositions. Although chemical preservatives have excellent antibacterial properties, they can cause skin irritation or affect formulation stability, and if used at high concentrations, there is a concern that they may have adverse effects on skin health in the long term.

[0003] Accordingly, there is a demand for the development of natural preservatives that can replace chemical preservatives. However, natural preservatives have a limited antimicrobial spectrum, and relatively high concentrations must be applied to achieve a preservative effect equivalent to that of chemical preservatives. Furthermore, there are limitations in that using natural preservatives at high concentrations can lead to reduced formulation stability or skin irritation. Prior art literature

[0004] Republic of Korea Published Patent No. 10-2024-0099595 The problem to be solved

[0005] The purpose of this application is to provide a preservative composition and a cosmetic composition containing the same. means of solving the problem

[0006] A preservative composition is provided according to an embodiment of the present application. The preservative composition may include propylene glycol caprylate and glyceryl caprylate.

[0007] In addition, the above preservative composition may further include one or more of caprylyl glycol or 2,3-butanediol.

[0008] In addition, the glyceryl caprylate may be included in an amount of 0.1 to 2 parts by weight per 1 part by weight of the propylene glycol caprylate.

[0009] In addition, the caprylyl glycol may be included in an amount of 1 part by weight or less for every 1 part by weight of the propylene glycol caprylate.

[0010] In addition, the 2,3-butanediol may be included in an amount of 10 parts by weight or less per 1 part by weight of the propylene glycol caprylate.

[0011] A cosmetic composition is provided according to an embodiment of the present application. The cosmetic composition may include a preservative composition according to an embodiment of the present application.

[0012] In addition, the above preservative composition may be included in an amount of 0.01 to 4 weight percent based on the total weight of the cosmetic composition.

[0013] In addition, the above cosmetic composition may have excellent formulation stability.

[0014] In addition, the above cosmetic composition may have low skin irritation. Effects of the invention

[0015] According to an embodiment of the present application, sufficient preservative effects can be exhibited by using ingredients derived from natural products, and a cosmetic composition exhibiting excellent preservative effects by including the same can be provided.

[0016] In addition, according to an embodiment of the present application, a cosmetic composition having a low risk of skin irritation and excellent formulation stability can be provided by including a naturally derived preservative.

[0017] The effects obtainable from the embodiments of the present application are not limited to those mentioned above, and other unmentioned effects will be clearly understood by those skilled in the art to which the present application belongs from the description below. Specific details for implementing the invention

[0018] The structural or functional descriptions of the embodiments disclosed in this specification are merely illustrative for the purpose of explaining embodiments according to the technical concept of this application. Furthermore, embodiments according to the technical concept of this application may be implemented in various forms other than those disclosed in this specification. Additionally, the technical concept of this application is not to be interpreted as being limited to the embodiments described in this specification.

[0019] Among the physical properties mentioned in this specification, if the measurement temperature affects the property, the property is the one measured at room temperature and pressure unless otherwise specifically stipulated.

[0020] Unless otherwise specifically defined among the physical properties mentioned in this specification, said physical properties may basically follow the SI unit system. For example, weight may be expressed in kg units, and length may be expressed in m units.

[0021] The term "room temperature" as used in this specification refers to a natural temperature that is not heated or cooled, and may mean, for example, any temperature within the range of 10°C to 30°C, for example, about 15°C or higher, about 18°C ​​or higher, about 20°C or higher, about 23°C or higher, about 27°C or lower, or 25°C. Unless specifically defined in this specification, the unit of temperature is Celsius (°C).

[0022] The term "relatively high temperature relative to room temperature" as used in this specification refers to a temperature higher than room temperature, and may mean, for example, any temperature within the range of 30°C to 50°C, for example, about 35°C or higher, about 40°C or higher, or about 45°C or lower.

[0023] Among the physical properties mentioned in this specification, if the measured pressure affects the physical property, unless otherwise specifically defined, the physical property is the property measured at atmospheric pressure. The term atmospheric pressure used in this specification refers to natural pressure that is not pressurized or depressurized, and typically refers to atmospheric pressure within the range of about 700 mmHg to 800 mmHg.

[0024] As used in this specification, the terms a to b refer to a range between a and b, including a and b. For example, "included in parts by weight of a to b" is equivalent to "included within the range of parts by weight of a to b."

[0025] The terms used herein are for describing embodiments and are not intended to limit or / or restrict the present application. Singular expressions include plural expressions unless the context clearly indicates otherwise. Additionally, numbers used herein (e.g., First, Second, etc.) are merely identifiers to distinguish one component from another.

[0026] Furthermore, in this application, the term "or" is intended to mean an implicit "or" rather than an exclusive "or." That is, unless otherwise specified or evident from the context, "X uses A or B" is intended to mean one of the natural implicit substitutions. In other words, if X uses A; if X uses B; or if X uses both A and B, "X uses A or B" may apply to any of these cases. Additionally, the term "and / or" as used herein should be understood to refer to and include all possible combinations of one or more of the enumerated related configurations.

[0028] A preservative composition is provided according to an embodiment of the present application. The preservative composition may include propylene glycol caprylate and glyceryl caprylate.

[0029] In this application, the term “preservative composition” refers to a component that has the effect of inhibiting or eliminating the growth of microorganisms and maintains the stability and safety of a product containing the preservative composition. The preservative composition can prevent product spoilage and extend the shelf life, as well as ensure the safety of consumers using the product.

[0030] In this application, the “preservative effect” refers to inhibiting or killing the growth of microorganisms, and may, for example, mean preventing quality changes caused by microorganisms in a cosmetic composition. The preservative effect may include an antibacterial effect against bacteria and an antifungal effect against mold or yeast.

[0031] In the examples, the preservative composition is Staphylococcus aureus ( Staphylococcus aureus ), E. coli( Escherichia coli ), Candida ( Candida albicans ) or mold ( Aspergillus brasiliensis It can exhibit a preservative effect on one or more of the following.

[0032] Propylene Glycol Caprylate (PGC) and Glyceryl Caprylate (GC) are compounds based on Caprylic Acid, a natural fatty acid extracted from coconut oil, palm oil, etc.

[0033] In the examples, 0.1 to 2 parts by weight of glyceryl caprylate may be included per 1 part by weight of propylene glycol caprylate.

[0034] In the examples, the preservative composition may further include one or more of caprylyl glycol or 2,3-butanediol.

[0035] In the examples, caprylyl glycol may be included in an amount of 1 part by weight or less per 1 part by weight of propylene glycol caprylate. For example, caprylyl glycol may be included in an amount of 0.0001 parts by weight or more, 0.001 parts by weight or more, 0.01 parts by weight or more, or 0.1 parts by weight or more, or 1 part by weight or less per 1 part by weight of propylene glycol caprylate.

[0036] In the examples, 2,3-butanediol may be included in an amount of 10 parts by weight or less per 1 part by weight of propylene glycol caprylate. For example, 2,3-butanediol may be included in an amount of 0.0001 parts by weight or more, 0.001 parts by weight or more, 0.01 parts by weight or more, or 0.1 parts by weight or more, or 10 parts by weight or less per 1 part by weight of propylene glycol caprylate.

[0038] A cosmetic composition is provided according to an embodiment of the present application. The cosmetic composition may include a preservative composition according to an embodiment of the present application.

[0039] In the examples, the preservative composition may be included in an amount of 0.01 wt% or more, 0.02 wt% or more, 0.03 wt% or more, 0.04 wt% or more, 0.05 wt% or more, 0.06 wt% or more, 0.07 wt% or more, 0.08 wt% or more, 0.09 wt% or more, or 0.1 wt% or more, or 4 wt% or less, 3.5 wt% or less, 3 wt% or less, 2.5 wt% or less, or 2 wt% or less, based on the total weight of the cosmetic composition.

[0040] In the examples, the cosmetic composition may have excellent formulation stability. For example, when the cosmetic composition is stored at 25°C and 45°C for 30 days, the formulation of the cosmetic composition may remain stable without separation, thus having excellent formulation stability.

[0041] In the examples, the preservative composition or the cosmetic composition containing it may have low skin irritation. For example, despite having excellent preservative effects, the cosmetic composition may be usable on sensitive skin due to low skin irritation, such as skin redness.

[0042] In the examples, the preservative composition or the cosmetic composition containing the same can provide a cosmetic composition that has excellent preservative effect even in small amounts, excellent formulation stability, and low risk of skin irritation, depending on the synergistic effect of the naturally derived preservative ingredients.

[0044] In the examples, the cosmetic composition may further include additives commonly used in the art to the extent that the effects of the examples of the present application are not impaired. For example, the cosmetic composition may further include thickeners, pH adjusters, surfactants, stabilizers, preservatives, disinfectants, moisturizers, sunscreens, skin conditioning agents, whitening agents, colorants, organic pigments, inorganic pigments, fragrances, vitamins, natural colorants, pearls, and other functional ingredients. Here, the functional ingredients may include, for example, wrinkle-improving ingredients, whitening ingredients, antioxidant ingredients, anti-aging ingredients, plumping ingredients, exfoliating ingredients, scrub ingredients, moisturizing ingredients, skin barrier strengthening ingredients, skin elasticity-enhancing ingredients, etc. The amount of the above ingredients can be easily selected by a person skilled in the art within a range that is not impaired by the purpose and effects of the present application.

[0045] In the examples, the cosmetic composition can be manufactured into various products. For example, it can be manufactured into sun care products such as sun cream, sun stick, sun milk, sun lotion, and sun cushion. For example, it can be manufactured into functional cosmetics such as nourishing cream, essence, and ampoule, or into basic cosmetics such as toner and lotion. In addition, it can be manufactured into color cosmetics such as lipstick, lip balm, mascara, blush, shading, highlighter, makeup base, foundation, compact powder, concealer, and skin cover. Furthermore, it can be manufactured into products that are attached to the skin, such as packs and hydrogel slimming patches, or products that are sprayed onto the skin, such as mist and aerosol.

[0047] The present invention will be explained below through examples and experimental examples, but the scope of the present invention is not limited by the contents presented below.

[0049] Examples and Comparative Examples

[0051] Examples 1 to 12: Preparation of a composition having a preservative effect

[0052] Compositions having a preservative effect were prepared as shown in Tables 1 and 2. The units of the values ​​listed in Tables 1 and 2 are weight (g).

[0054] division Example 1 Example 2 Example 3 Example 4 Example 5 Propylene glycol caprylate (PGC) 1 1 1 4 0.5 Glyceryl caprylate (GC) 0.1 1 2 0.4 1 PGC:GC 1:0.1 1:1 1:2 1:0.1 1:2

[0056] division Example 6 Example 7 Example 8 Example 9 Example 10 Example 11 Example 12 Propylene glycol caprylate 1 1 1 1 1 1 1 Glyceryl caprylate 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Caprylyl glycol 0.1 0.5 1 - - - 0.3 2,3-butanediol - - - 1 5 10 3

[0058] Comparative Examples 1 to 12: Preparation of compositions having a preservative effect with controlled components or content

[0059] Compositions having a preservative effect were prepared by adjusting the components or content as shown in Tables 3 to 5. The units of the values ​​listed in Tables 3 to 5 are weight (g).

[0061] division Comparative Example 1 Comparative Example 2 Propylene glycol caprylate 4 - Glyceryl caprylate - 2

[0063] division Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 Propylene glycol caprylate (PGC) 1 1 4 5.5 0.2 0.7 Glyceryl caprylate (GC) 0.01 3 0.2 0.5 2 1.54 PGC:GC 1:0.01 1:3 1:0.05 1:0.09 1:10 1:2.2

[0065] division Comparative Example 9 Comparative Example 10 Comparative Example 11 Comparative Example 12 Propylene glycol caprylate 1 1 1 1 Glyceryl caprylate 0.1 0.1 0.1 0.1 Caprylyl glycol 1.5 - - - 2,3-butanediol - 12 - - 1,2-butanediol - - 5 - 1,3-butanediol - - - 5

[0067] Manufacturing example and comparative manufacturing example

[0069] Preparation Examples 1 to 12: Cream

[0070] Cosmetic compositions in the form of creams, comprising Examples 1 to 12 as shown in Tables 6 and 7, were prepared. The units of the values ​​listed in Tables 6 and 7 are weight%. Examples 1 to 12 are included at 2 weight% of the total weight of the cosmetic composition, and the weight ratios of each component according to Tables 1 and 2 were maintained identically.

[0072] division Preparation Example 1 Preparation Example 2 Preparation Example 3 Preparation Example 4 Preparation Example 5 Preparation Example 6 premier purified water to 100 to 100 to 100 to 100 to 100 to 100 Xanthan sword 1.5 1.5 1.5 1.5 1.5 1.5 paid Polyglyceryl-3 distearate 2.5 2.5 2.5 2.5 2.5 2.5 Arachidylglucoside 0.4 0.4 0.4 0.4 0.4 0.4 Arachidyl alcohol 1.5 1.5 1.5 1.5 1.5 1.5 Caprylic Capric Triglyceride 5.0 5.0 5.0 5.0 5.0 5.0 Coco-caprylate / Caprate 5.5 5.5 5.5 5.5 5.5 5.5 cetearyl alcohol 3.0 3.0 3.0 3.0 3.0 3.0 Glyceryl stearate 1.0 1.0 1.0 1.0 1.0 1.0 Preservatives Example 1 2.0 - - - - - Example 2 - 2.0 - - - - Example 3 - - 2.0 - - - Example 4 - - - 2.0 - - Example 5 - - - - 2.0 - Example 6 - - - - - 2.0

[0074] division Preparation Example 7 Preparation Example 8 Preparation Example 9 Preparation Example 10 Preparation Example 11 Preparation Example 12 premier purified water to 100 to 100 to 100 to 100 to 100 to 100 Xanthan sword 1.5 1.5 1.5 1.5 1.5 1.5 paid Polyglyceryl-3 distearate 2.5 2.5 2.5 2.5 2.5 2.5 Arachidylglucoside 0.4 0.4 0.4 0.4 0.4 0.4 Arachidyl alcohol 1.5 1.5 1.5 1.5 1.5 1.5 Caprylic Capric Triglyceride 5.0 5.0 5.0 5.0 5.0 5.0 Coco-caprylate / Caprate 5.5 5.5 5.5 5.5 5.5 5.5 cetearyl alcohol 3.0 3.0 3.0 3.0 3.0 3.0 Glyceryl stearate 1.0 1.0 1.0 1.0 1.0 1.0 Preservatives Example 7 2.0 - - - - - Example 8 - 2.0 - - - - Example 9 - - 2.0 - - - Example 10 - - - 2.0 - - Example 11 - - - - 2.0 - Example 12 - - - - - 2.0

[0076] Comparative Manufacturing Examples 1 to 12: Cream

[0077] Cosmetic compositions in the form of cream formulations containing Comparative Examples 1 to 12 were prepared as shown in Tables 8 and 9. The units of the values ​​listed in Tables 8 and 9 are weight%. Comparative Examples 1 to 12 were included at 2 weight% of the total weight of the cosmetic composition, and the weight ratios of each component according to Tables 3 to 5 were maintained identically.

[0079] division Comparative Manufacturing Example 1 Comparative Manufacturing Example 2 Comparative Manufacturing Example 3 Comparative Manufacturing Example 4 Comparative Manufacturing Example 5 Comparative Manufacturing Example 6 premier purified water to 100 to 100 to 100 to 100 to 100 to 100 Xanthan sword 1.5 1.5 1.5 1.5 1.5 1.5 paid Polyglyceryl-3 distearate 2.5 2.5 2.5 2.5 2.5 2.5 Arachidylglucoside 0.4 0.4 0.4 0.4 0.4 0.4 Arachidyl alcohol 1.5 1.5 1.5 1.5 1.5 1.5 Caprylic Capric Triglyceride 5.0 5.0 5.0 5.0 5.0 5.0 Coco-caprylate / Caprate 5.5 5.5 5.5 5.5 5.5 5.5 cetearyl alcohol 3.0 3.0 3.0 3.0 3.0 3.0 Glyceryl stearate 1.0 1.0 1.0 1.0 1.0 1.0 Preservatives Comparative Example 1 2.0 - - - - - Comparative Example 2 - 2.0 - - - - Comparative Example 3 - - 2.0 - - - Comparative Example 4 - - - 2.0 - - Comparative Example 5 - - - - 2.0 - Comparative Example 6 - - - - - 2.0

[0081] division Comparative Manufacturing Example 7 Comparative Manufacturing Example 8 Comparative Manufacturing Example 9 Comparative Manufacturing Example 10 Comparative Manufacturing Example 11 Comparative Manufacturing Example 12 premier purified water to 100 to 100 to 100 to 100 to 100 to 100 Xanthan sword 1.5 1.5 1.5 1.5 1.5 1.5 paid Polyglyceryl-3 distearate 2.5 2.5 2.5 2.5 2.5 2.5 Arachidylglucoside 0.4 0.4 0.4 0.4 0.4 0.4 Arachidyl alcohol 1.5 1.5 1.5 1.5 1.5 1.5 Caprylic Capric Triglyceride 5.0 5.0 5.0 5.0 5.0 5.0 Coco-caprylate / Caprate 5.5 5.5 5.5 5.5 5.5 5.5 cetearyl alcohol 3.0 3.0 3.0 3.0 3.0 3.0 Glyceryl stearate 1.0 1.0 1.0 1.0 1.0 1.0 Preservatives Comparative Example 7 2.0 - - - - - Comparative Example 8 - 2.0 - - - - Comparative Example 9 - - 2.0 - - - Comparative Example 10 - - - 2.0 - - Comparative Example 11 - - - - 2.0 - Comparative Example 12 - - - - - 2.0

[0083] Preparation Examples 13 to 15: UV blockers

[0084] A sunscreen containing Example 1, Example 10, or Example 12 was prepared as shown in Table 10. The units of the values ​​listed in Table 10 are weight%. Example 1, Example 10, or Example 12 is included at 2 weight% of the total weight of the cosmetic composition, and the weight ratios of each component according to Tables 1 and 2 were maintained identically.

[0086] division Preparation Example 13 Preparation Example 14 Preparation Example 15 premier purified water to 100 to 100 to 100 Xanthan sword 1.5 1.5 1.5 Sodium hyaluronate 0.3 0.3 0.3 titanium dioxide 3.0 3.0 3.0 paid Polyglyceryl-3 distearate 2.0 2.0 2.0 Glyceryl stearate 1.0 1.0 1.0 Dibutyl adipate 8.0 6.0 6.0 Ethylhexyl triazone 3.0 3.0 3.0 Bis-ethylhexyloxyphenol methoxyphenyl triazine 2.5 2.5 2.5 Diethylamino hydroxybenzoylhexyl benzoate 4.0 4.0 4.0 cetearyl alcohol 2.0 2.0 2.0 Caprylic Capric Triglyceride 3.0 3.0 3.0 Ethylhexyl stearate 5.0 5.0 5.0 Preservatives Example 1 2.0 - - Example 10 - 2.0 - Example 12 - - 2.0

[0088] Comparative Manufacturing Examples 13 and 14: UV blockers

[0089] A sunscreen containing Comparative Example 6 or Comparative Example 12 was prepared as shown in Table 11. The units of the values ​​listed in Table 11 are weight%. Comparative Example 6 or Comparative Example 12 is included at 2 weight% of the total weight of the cosmetic composition, and the weight ratios of each component according to Tables 4 and 5 were maintained identically.

[0091] division Comparative Manufacturing Example 13 Comparative Manufacturing Example 14 premier purified water to 100 to 100 Xanthan sword 1.5 1.5 Sodium hyaluronate 0.3 0.3 titanium dioxide 3.0 3.0 paid Polyglyceryl-3 distearate 2.0 2.0 Glyceryl stearate 1.0 1.0 Dibutyl adipate 8.0 6.0 Ethylhexyl triazone 3.0 3.0 Bis-ethylhexyloxyphenol methoxyphenyl triazine 2.5 2.5 Diethylamino hydroxybenzoylhexyl benzoate 4.0 4.0 cetearyl alcohol 2.0 2.0 Caprylic Capric Triglyceride 3.0 3.0 Ethylhexyl stearate 5.0 5.0 Preservatives Comparative Example 6 2.0 - Comparative Example 12 - 2.0

[0093] Preparation Examples 16 to 18: Lip gloss

[0094] A lip gloss comprising Example 1, Example 10, or Example 12 was prepared as shown in Table 12. The units of the values ​​listed in Table 12 are weight%. Example 1, Example 10, or Example 12 is included at 2 weight% of the total weight of the cosmetic composition, and the weight ratios of each component according to Tables 1 and 2 were maintained identically.

[0096] division Preparation Example 16 Preparation Example 17 Preparation Example 18 premier purified water to 100 to 100 to 100 Polyacrylate Crosspolymer-6 0.3 0.3 0.3 Sodium polyacrylate 0.5 0.5 0.5 Xanthan sword 1.5 1.5 1.5 Sodium hyaluronate 0.3 0.3 0.3 paid Polyglyceryl-2 Triisostearate 5.0 5.0 5.0 Distearate malate 10.0 10.0 10.0 Sorbitan monostearate 1.0 1.0 1.0 Jojoba seed oil 6.0 6.0 6.0 rice bran wax 2.0 2.0 2.0 Canterilla Wax 3.0 3.0 3.0 Caprylic Capric Triglyceride 3.0 3.0 3.0 Octyldodecanol 5.0 5.0 5.0 Hydrogenated polyisobutene 10.0 10.0 10.0 pigment Appropriate amount Appropriate amount Appropriate amount Preservatives Example 1 2.0 - - Example 10 - 2.0 - Example 12 - - 2.0

[0098] Comparative Manufacturing Examples 15 and 16: Lip gloss

[0099] A lip gloss containing Comparative Example 6 or Comparative Example 12 was prepared as shown in Table 13. The units of the values ​​listed in Table 13 are weight%. Comparative Example 6 or Comparative Example 12 is included at 2 weight% of the total weight of the cosmetic composition, and the weight ratios of each component according to Tables 4 and 5 were maintained identically.

[0101] division Comparative Manufacturing Example 15 Comparative Manufacturing Example 16 premier purified water to 100 to 100 Polyacrylate Crosspolymer-6 0.3 0.3 Sodium polyacrylate 0.5 0.5 Xanthan sword 1.5 1.5 Sodium hyaluronate 0.3 0.3 paid Polyglyceryl-2 Triisostearate 5.0 5.0 Distearate malate 10.0 10.0 Sorbitan monostearate 1.0 1.0 Jojoba seed oil 6.0 6.0 rice bran wax 2.0 2.0 Canterilla Wax 3.0 3.0 Caprylic Capric Triglyceride 3.0 3.0 Octyldodecanol 5.0 5.0 Hydrogenated polyisobutene 10.0 10.0 pigment Appropriate amount Appropriate amount Preservatives Comparative Example 6 2.0 - Comparative Example 12 - 2.0

[0103] Experimental Example

[0105] Experimental Example 1: Evaluation of Conservation Power

[0106] In accordance with ISO 11930 guidelines, the preservation efficacy of five test strains was evaluated as satisfactory or unsatisfactory. After inoculating and mixing the bacterial suspension into each composition, the inoculated samples were cultured, and 1g samples were obtained at intervals of 7, 14, and 28 days. The obtained samples were diluted in a neutralization medium (Modified Letheen Broth) and cultured according to the culture temperature and duration for each strain to measure the bacterial count. The dilution rates were set at 10, 100, and 1,000 times, with different dilution ratios applied per week and per strain.

[0108] The experimental results are shown in Tables 14 to 17.

[0110] Staphylococcus aureus ( Staphylococcus aureus ) division Initial bacterial count Day 7 Day 14 Day 28 result Preparation Example 1 7.9X10 5 <10 2 <10 <10 fitness Preparation Example 2 7.9X10 5 <10 2 <10 <10 fitness Preparation Example 3 7.9X10 5 <10 2 <10 <10 fitness Preparation Example 4 7.9X10 5 <10 2 <10 <10 fitness Preparation Example 5 7.9X10 5 <10 2 <10 <10 fitness Preparation Example 6 7.9X10 5 <10 2 <10 <10 fitness Preparation Example 7 7.9X10 5 <10 2 <10 <10 fitness Preparation Example 8 7.9X10 5 <10 2 <10 <10 fitness Preparation Example 9 7.9X10 5 <10 2 <10 <10 fitness Preparation Example 10 7.9X10 5 <10 2 <10 <10 fitness Preparation Example 11 7.9X10 5 <10 2 <10 <10 fitness Preparation Example 12 7.9X10 5 <10 2 <10 <10 fitness Comparative Manufacturing Example 1 7.9X10 5 6.0X10 3 7.0X10 2 <10 Non-conforming Comparative Manufacturing Example 2 7.9X10 5 4.0X10 3 8.0X10 2 <10 Non-conforming Comparative Manufacturing Example 3 7.9X10 5 8.0X10 3 8.0X10 2 <10 Non-conforming Comparative Manufacturing Example 4 7.9X10 5 5.2X10 3 5.2X10 2 <10 Non-conforming Comparative Manufacturing Example 5 7.9X10 5 <10 2 <10 <10 fitness Comparative Manufacturing Example 6 7.9X10 5 5.0X10 3 6.0X10 2 <10 Non-conforming Comparative Manufacturing Example 7 7.9X10 5 3.0X10 3 6.0X10 2 <10 Non-conforming Comparative Manufacturing Example 8 7.9X10 5 9.0X10 2 1.0X10 2 <10 Non-conforming Comparative Manufacturing Example 9 7.9X10 5 5.4X10 3 4.0X10 2 <10 Non-conforming Comparative Manufacturing Example 10 7.9X10 5 5.6X10 3 5.0X10 2 <10 Non-conforming Comparative Manufacturing Example 11 7.9X10 5 4.8X10 3 3.0X10 2 <10 Non-conforming Comparative Manufacturing Example 12 7.9X10 5 5.5X10 3 2.0X10 2 <10 Non-conforming

[0112] E. coli ( Escherichia coli ) division Initial bacterial count Day 7 Day 14 Day 28 result Preparation Example 1 4.5X10 5 <10 2 <10 <10 fitness Preparation Example 2 4.5X10 5 <10 2 <10 <10 fitness Preparation Example 3 4.5X10 5 <10 2 <10 <10 fitness Preparation Example 4 4.5X10 5 <10 2 <10 <10 fitness Preparation Example 5 4.5X10 5 <10 2 <10 <10 fitness Preparation Example 6 4.5X10 5 <10 2 <10 <10 fitness Preparation Example 7 4.5X10 5 <10 2 <10 <10 fitness Preparation Example 8 4.5X10 5 <10 2 <10 <10 fitness Preparation Example 9 4.5X10 5 <10 2 <10 <10 fitness Preparation Example 10 4.5X10 5 <10 2 <10 <10 fitness Preparation Example 11 4.5X10 5 <10 2 <10 <10 fitness Preparation Example 12 4.5X10 5 <10 2 <10 <10 fitness Comparative Manufacturing Example 1 4.5X10 5 3.0X10 3 3.0X10 2 <10 Non-conforming Comparative Manufacturing Example 2 4.5X10 5 2.0X10 3 5.0X10 2 <10 Non-conforming Comparative Manufacturing Example 3 4.5X10 5 4.0X10 3 3.0X10 2 <10 Non-conforming Comparative Manufacturing Example 4 4.5X10 5 8.0X10 3 1.0X10 2 <10 Non-conforming Comparative Manufacturing Example 5 4.5X10 5 <10 2 <10 <10 fitness Comparative Manufacturing Example 6 4.5X10 5 9.0X10 3 2.0X10 2 <10 Non-conforming Comparative Manufacturing Example 7 4.5X10 5 1.0X10 3 2.0X10 2 <10 Non-conforming Comparative Manufacturing Example 8 4.5X10 5 5.0X10 2 1.0X10 2 <10 Non-conforming Comparative Manufacturing Example 9 4.5X10 5 7.0X10 3 <10 <10 Non-conforming Comparative Manufacturing Example 10 4.5X10 5 5.0X10 3 <10 <10 Non-conforming Comparative Manufacturing Example 11 4.5X10 5 6.0X10 3 <10 <10 Non-conforming Comparative Manufacturing Example 12 4.5X10 5 5.5X10 3 <10 <10 Non-conforming

[0114] Candida fungus Candida albicans ) division Initial bacterial count Day 7 Day 14 Day 28 result Preparation Example 1 4.4X10 4 <10 2 <10 <10 fitness Preparation Example 2 4.4X10 4 <10 2 <10 <10 fitness Preparation Example 3 4.4X10 4 <10 2 <10 <10 fitness Preparation Example 4 4.4X10 4 <10 2 <10 <10 fitness Preparation Example 5 4.4X10 4 <10 2 <10 <10 fitness Preparation Example 6 4.4X10 4 <10 2 <10 <10 fitness Preparation Example 7 4.4X10 4 <10 2 <10 <10 fitness Preparation Example 8 4.4X10 4 <10 2 <10 <10 fitness Preparation Example 9 4.4X10 4 <10 2 <10 <10 fitness Preparation Example 10 4.4X10 4 <10 2 <10 <10 fitness Preparation Example 11 4.4X10 4 <10 2 <10 <10 fitness Preparation Example 12 4.4X10 4 <10 2 <10 <10 fitness Comparative Manufacturing Example 1 4.4X10 4 8.0X10 3 4.0X10 2 <10 Non-conforming Comparative Manufacturing Example 2 4.4X10 4 6.0X10 3 2.0X10 2 <10 Non-conforming Comparative Manufacturing Example 3 4.4X10 4 5.0X10 3 1.0X10 2 <10 Non-conforming Comparative Manufacturing Example 4 4.4X10 4 6.2X10 3 1.0X10 2 <10 Non-conforming Comparative Manufacturing Example 5 4.4X10 4 <10 2 <10 <10 fitness Comparative Manufacturing Example 6 4.4X10 4 7.5X10 3 3.0X10 2 <10 Non-conforming Comparative Manufacturing Example 7 4.4X10 4 7.0X10 3 2.0X10 2 <10 Non-conforming Comparative Manufacturing Example 8 4.4X10 4 <10 2 <10 <10 fitness Comparative Manufacturing Example 9 4.4X10 4 4.9X10 3 1.0X10 2 <10 Non-conforming Comparative Manufacturing Example 10 4.4X10 4 5.6X10 3 1.0X10 2 <10 Non-conforming Comparative Manufacturing Example 11 4.4X10 4 6.1X10 3 2.0X10 2 <10 Non-conforming Comparative Manufacturing Example 12 4.4X10 4 6.5X10 3 3.0X10 2 <10 Non-conforming

[0116] Fungal pathogens Aspergillus brasiliensis ) division Initial bacterial count Day 7 Day 14 Day 28 result Preparation Example 1 4.2X10 4 8.5X10 3 8.0X10 3 3.5X10 3 fitness Preparation Example 2 4.2X10 4 6.0X10 3 5.0X10 3 1.0X10 3 fitness Preparation Example 3 4.2X10 4 4.0X10 3 2.0X10 3 9.0X10 2 fitness Preparation Example 4 4.2X10 4 3.0X10 3 1.0X10 3 9.0X10 2 fitness Preparation Example 5 4.2X10 4 7.0X10 3 6.0X10 3 1.5X10 3 fitness Preparation Example 6 4.2X10 4 6.5X10 3 3.0X10 3 8.0X10 2 fitness Preparation Example 7 4.2X10 4 5.0X10 3 1.0X10 3 6.0X10 2 fitness Preparation Example 8 4.2X10 4 3.0X10 3 6.0X10 2 <10 2 fitness Preparation Example 9 4.2X10 4 7.0X10 3 6.0X10 3 1.5X10 3 fitness Preparation Example 10 4.2X10 4 6.0X10 3 5.0X10 3 1.0X10 3 fitness Preparation Example 11 4.2X10 4 2.0X10 3 5.0X10 2 <10 2 fitness Preparation Example 12 4.2X10 4 4.0X10 3 6.0X10 2 5.0X10 2 fitness Comparative Manufacturing Example 1 4.2X10 4 3.0X10 4 2.5X10 4 1.5X10 4 Non-conforming Comparative Manufacturing Example 2 4.2X10 4 2.8X10 4 1.9X10 4 1.4X10 4 Non-conforming Comparative Manufacturing Example 3 4.2X10 4 4.0X10 4 2.5X10 4 1.5X10 4 Non-conforming Comparative Manufacturing Example 4 4.2X10 4 8.0X10 3 6.0X10 3 4.5X10 3 Non-conforming Comparative Manufacturing Example 5 4.2X10 4 1.0X10 4 8.0X10 3 6.0X10 3 Non-conforming Comparative Manufacturing Example 6 4.2X10 4 9.0X10 3 6.0X10 3 5.0X10 3 Non-conforming Comparative Manufacturing Example 7 4.2X10 4 2.7X10 4 1.7X10 4 1.0X10 4 Non-conforming Comparative Manufacturing Example 8 4.2X10 4 9.0X10 3 8.0X10 3 6.0X10 2 Non-conforming Comparative Manufacturing Example 9 4.2X10 4 1.0X10 4 9.0X10 3 5.0X10 3 Non-conforming Comparative Manufacturing Example 10 4.2X10 4 8.0X10 3 6.5X10 3 5.0X10 3 Non-conforming Comparative Manufacturing Example 11 4.2X10 4 1.5X10 4 8.0X10 3 5.5X10 3 Non-conforming Comparative Manufacturing Example 12 4.2X10 4 2.0X10 4 8.5X10 3 6.5X10 3 Non-conforming

[0118] As a result of the experiment, the composition according to the example satisfied the criteria for evaluating preservation efficacy against Staphylococcus aureus, Escherichia coli, Candida, and fungi. That is, it can be confirmed that the composition according to the example, containing propylene glycol caprylate and glyceryl caprylate in a specific ratio, has a broad antimicrobial spectrum and exhibits excellent preservative effects.

[0119] In contrast, Comparative Examples 1 and 2, which contain only one of propylene glycol caprylate or glyceryl caprylate; Comparative Examples 3, 4, 7, and 8, in which the content ratio of the two components falls outside a specific range; and Comparative Examples 11 and 12, which contain 1,2-butanediol or 1,3-butanediol, did not exhibit a broad antibacterial spectrum like that of the Examples, and in particular, lacked a preservative effect against the fungus Aspergillus brasiliensis.

[0121] Experimental Example 2: Formulation Stability Evaluation

[0122] The formulation stability of the preparation example and comparative preparation example was evaluated. Each composition was stored at 25°C or 45°C for 30 days immediately after preparation. Afterward, the appearance was visually observed at room temperature for 7 days, and the formulation stability was evaluated as good (O) or separated (X).

[0124] The experimental results are shown in Table 18.

[0126] division 25℃ 45℃ Preparation Example 1 O O Preparation Example 2 O O Preparation Example 3 O O Preparation Example 4 O O Preparation Example 5 O O Preparation Example 6 O O Preparation Example 7 O O Preparation Example 8 O O Preparation Example 9 O O Preparation Example 10 O O Preparation Example 11 O O Preparation Example 12 O O Comparative Manufacturing Example 1 X X Comparative Manufacturing Example 2 X X Comparative Manufacturing Example 3 O X Comparative Manufacturing Example 4 X X Comparative Manufacturing Example 5 X X Comparative Manufacturing Example 6 X X Comparative Manufacturing Example 7 X X Comparative Manufacturing Example 8 X X Comparative Manufacturing Example 9 X X Comparative Manufacturing Example 10 X X Comparative Manufacturing Example 11 O X Comparative Manufacturing Example 12 O X Preparation Example 13 O O Preparation Example 14 O O Preparation Example 15 O O Comparative Manufacturing Example 13 X X Comparative Manufacturing Example 14 O X Preparation Example 16 O O Preparation Example 17 O O Preparation Example 18 O O Comparative Manufacturing Example 15 X X Comparative Manufacturing Example 16 O X

[0128] As a result of the experiment, Preparation Examples 1 to 18 all exhibited excellent stability, as no separation of the formulation was observed even after being stored for 30 days under conditions of 25°C and 45°C. In other words, it can be seen that when the preservative composition according to the embodiments of the present application is applied to cosmetics of various formulations, such as creams, sunscreens, and lip glosses, product stability can be ensured over a wide temperature range.

[0129] In contrast, comparative manufacturing examples containing the composition of the comparative example were found to have poor stability, with formulation separation occurring at 25°C or 45°C in most cases.

[0131] Experimental Example 3: Skin Irritation Evaluation

[0132] Skin irritation of the Preparation Example and Comparative Preparation Example was evaluated. Twenty healthy men and women in their 20s and 30s were tested on the forearms (50 cm) of both arms. 2 A fixed amount (approx. 0.2 g) of the sample was applied to the site for 48 hours, after which it was removed. The application site was marked with a skin marking pen, and the results were evaluated visually after 1 hour, 24 hours, and 48 hours. The evaluation criteria are listed in Table 19, and the experimental results are shown in Table 20.

[0134] division metewand - No redness or specific issues +- Slightly redder than the surroundings + Becomes significantly redder than the surroundings ++ Becomes more severely red and swollen than the surrounding area

[0136] division skin irritation Preparation Example 1 - Preparation Example 2 - Preparation Example 3 - Preparation Example 4 - Preparation Example 5 - Preparation Example 6 - Preparation Example 7 - Preparation Example 8 - Preparation Example 9 - Preparation Example 10 - Preparation Example 11 - Preparation Example 12 - Comparative Manufacturing Example 1 - Comparative Manufacturing Example 2 +- Comparative Manufacturing Example 3 - Comparative Manufacturing Example 4 + Comparative Manufacturing Example 5 - Comparative Manufacturing Example 6 + Comparative Manufacturing Example 7 +- Comparative Manufacturing Example 8 - Comparative Manufacturing Example 9 - Comparative Manufacturing Example 10 +- Comparative Manufacturing Example 11 - Comparative Manufacturing Example 12 - Preparation Example 13 - Preparation Example 14 - Preparation Example 15 - Comparative Manufacturing Example 13 +- Comparative Manufacturing Example 14 - Preparation Example 16 - Preparation Example 17 - Preparation Example 18 - Comparative Manufacturing Example 15 +- Comparative Manufacturing Example 16 -

[0138] As a result of the experiment, Preparation Examples 1 to 18 were evaluated as having no skin irritation, as they did not cause any erythema or specific symptoms in the 48-hour test. In other words, it can be seen that the composition according to the examples has an excellent preservative effect while being very safe for use on human skin.

[0139] In contrast, in some comparative manufacturing examples such as Comparative Manufacturing Examples 2, 4, 6, 7, 10, 13, and 15, a phenomenon was observed where the skin became slightly redder or significantly redder than the surroundings, indicating that skin irritation was induced.

[0141] Foregoing, specific parts of the contents of this application have been described in detail. It will be apparent to those skilled in the art that such specific descriptions are merely preferred embodiments and do not limit the scope of this application. Accordingly, the actual scope of this application is defined by the appended claims and their equivalents.

Claims

Claim 1 A preservative composition comprising propylene glycol caprylate and glyceryl caprylate, having a preservative effect against Staphylococcus aureus, Escherichia coli, Candida albicans, and Aspergillus brasiliensis. Claim 2 In claim 1, the composition is a preservative composition further comprising one or more of caprylyl glycol or 2,3-butanediol. Claim 3 A preservative composition according to claim 1, comprising 0.1 to 2 parts by weight of glyceryl caprylate per 1 part by weight of propylene glycol caprylate. Claim 4 A preservative composition according to claim 2, comprising 1 part by weight or less of caprylyl glycol per 1 part by weight of propylene glycol caprylate. Claim 5 A preservative composition according to claim 2, comprising 10 parts by weight or less of 2,3-butanediol per 1 part by weight of propylene glycol caprylate. Claim 6 A cosmetic composition comprising the preservative composition of claim 1. Claim 7 In claim 6, the cosmetic composition comprises 0.01 to 4 weight percent of the preservative composition based on the total weight of the cosmetic composition. Claim 8 In claim 6, a cosmetic composition having excellent formulation stability. Claim 9 In paragraph 6, a cosmetic composition with low skin irritation.