Composition for spray-type oral wound coverings

Abstract

The present invention provides a spray-type oral wound dressing composition comprising 100 parts by weight of purified water; 5 to 10 parts by weight of a polyvinylpyrrolidone compound; 0.1 to 1 part by weight of calcium chloride; 0.1 to 1 part by weight of potassium sorbate; 1 to 3 parts by weight of propylene glycol; 0.05 to 0.2 parts by weight of EGF (Epidemal Growth Factor) liposomes; 0.1 to 1 part by weight of D-xylitol; and 0.1 to 3 parts by weight of at least one component selected from the group consisting of propolis extract, cranberry concentrate, Centella asiatica extract, hyaluronic acid, potassium diphosphate, magnesium chloride, lemon flavoring, and peppermint flavoring.

Description

Technology Field

[0001] The present invention is a technology in the field of medical devices or pharmaceuticals, and is a technology in the field of manufacturing oral wound dressings for protecting oral wounds and healing wounds. Background Technology

[0003] Wound dressings are a type of medical device or pharmaceutical used to form a thin film on the skin to protect wounds, prevent contamination, and stop the absorption of exudate and fluid loss. Generally, wound dressings are primarily products applied to the skin or joints, and compared to these, the variety of oral wound dressings is very limited.

[0004] Meanwhile, spray-type wound dressings are disclosed in Korean Registered Patent No. 10-1879643, etc. The aforementioned registered patent technology is characterized by the fact that foaming into a soft polyurethane foam proceeds after a certain period of time has elapsed following direct spraying onto the wound area, and it is a wound dressing technology that can be applied primarily to curved parts of the human body.

[0005] Meanwhile, regarding technology concerning wound dressings applicable to the oral cavity, Korean Published Patent No. 10-2017-0142875 provides a spray-type therapeutic composition as a component of its technical content, as a therapeutic composition for the prevention, improvement, or treatment of oral diseases. However, the technical features of the aforementioned patent lie in the therapeutic composition and are not a technology focused on the function of a wound dressing.

[0006] Examples of spray-type oral wound dressings available on the market include products such as Mucotin, Silgel, Kiomer 3, Dermagen, and Hiracel. Mucotin is an oral wound dressing for pets, and Silgel is a wound dressing containing self-drying silicone gel to protect and alleviate wounds or scars. Additionally, Kiomer 3 is a spray-type wound dressing containing chitosan and collagen components, and Dermagen and Hiracel are oral wound dressings that commonly contain allantoin components.

[0007] Although products are currently available on the market, the reality is that technological development in the field of spray-type oral wound dressings specialized for protecting oral wounds remains slow; therefore, the need for new technological development in this area is high. The problem to be solved

[0009] The present invention is considered in recognition of the technical realities of oral wound dressings and for the purpose of improving their performance, and aims to provide a spray-type oral wound dressing composition that has excellent effects in protecting and healing wounds and further promotes general oral health. means of solving the problem

[0010] A spray-type oral wound dressing composition according to one embodiment of the present invention comprises 100 parts by weight of purified water; 5 to 10 parts by weight of a polyvinylpyrrolidone compound; 0.1 to 1 part by weight of calcium chloride; 0.1 to 1 part by weight of potassium sorbate; 1 to 3 parts by weight of propylene glycol; 0.05 to 0.2 parts by weight of EGF (Epidemal Growth Factor) liposomes; 0.1 to 1 part by weight of D-xylitol; and 0.1 to 3 parts by weight of at least one component selected from the group consisting of propolis extract, cranberry concentrate, Centella asiatica extract, hyaluronic acid, potassium diphosphate, magnesium chloride, lemon flavoring, and peppermint flavoring.

[0011] As the purified water mentioned above, filtered water may be used after being left for 24 to 48 hours in the presence of basalt-derived ceramic powder, which is produced by melting crushed basalt powder at a temperature of 800°C to 1000°C below the complete melting temperature and cooling it to powder.

[0012] Indilipo rh-EGF (trade name) can be used as the above EGF liposome.

[0013] Polyvinylpyrrolidone K90 can be used as the above polyvinylpyrrolidone compound. Effects of the invention

[0015] The spray-type oral wound covering composition according to the present invention can be sprayed into the skin to stably protect the wound site and effectively maintain the body temperature of the wound site.

[0016] In addition, the above composition has excellent anti-inflammatory and antibacterial effects, which help promote rapid wound healing, and furthermore, can promote general oral health through the addition of functional ingredients. Brief explanation of the drawing

[0018] Figure 1 is an image showing the use of a spray-type oral wound dressing according to one embodiment of the present invention. FIG. 2 is an image of basalt-derived ceramic powder for pretreatment of purified water in a composition according to one embodiment of the present invention. FIG. 3 is a flowchart conceptually showing a method for manufacturing ceramic powder according to one embodiment of the present invention. Specific details for implementing the invention

[0019] Hereinafter, a spray-type oral wound covering composition according to one embodiment of the present invention will be described in detail. The following descriptions are exemplary descriptions intended to embody and explain the technical concept of the present invention, and the technical concept of the present invention is not limited by the following descriptions. The technical concept of the present invention may be interpreted and limited only by the claims set forth below.

[0020] Although the terms "wound dressing" or "wound dressing" may be confusing, the term "wound dressing" is interpreted as a term that includes a component having a predetermined shape. Since the technology according to one embodiment of the present invention consists of a pure liquid or gel-like composition and does not have a specific shape or component as a constituent, the term "wound dressing" will be used consistently below.

[0021] Figure 1 is an image showing the use of a spray-type oral wound dressing according to one embodiment of the present invention.

[0022] As shown in FIG. 1, the oral wound dressing composition is a spray type and is a composition that protects the wound site by spraying it onto the wound site in the oral cavity. The wound dressing made of the oral wound dressing composition performs a wound protection function by being sprayed onto a wound site with relatively little exudate, and is an adhesive, transparent gel-type wound dressing.

[0023] The above spray-type oral wound dressing composition comprises purified water, a polyvinylpyrrolidone compound, calcium chloride, potassium sorbate, propylene glycol, EGF (Epidemal Growth Factor) liposomes, D-xylitol, and other functional additives.

[0024] As the above-mentioned polyvinylpyrrolidone compound, polyvinylpyrrolidone K-90 may be used. Polyvinylpyrrolidone K-90 is a type of polyvinylpyrrolidone (PVP) and is a polymer of N-vinyl-2-pyrrolidone. The above-mentioned polyvinylpyrrolidone compound is a hygroscopic substance that dissolves easily in water, alcohol, amines, halohydrocarbons, etc., but does not dissolve in acetone, ether, etc. PVP-K-90 is a substance with a large molecular weight that possesses excellent adhesiveness, dispersibility, and cohesiveness, and at the same time, as a low-irritation substance, it performs a detoxification function. That is, it can combine with various toxic substances, viruses, dyes, pharmaceuticals, chemical substances, etc., to reduce the toxicity and irritation of the corresponding substances.

[0025] The above polyvinylpyrrolidone compound is included in the composition in an amount of 5 to 10 parts by weight relative to 100 parts by weight of the purified water. If the content of the above polyvinylpyrrolidone compound is less than 5 parts by weight, the adhesive properties of the wound dressing being manufactured may be significantly reduced, whereas if the content of the above polyvinylpyrrolidone compound exceeds 10 parts by weight, problems may occur in the spray properties of the wound dressing being manufactured due to a decrease in viscosity.

[0026] The aforementioned calcium chloride absorbs moisture from the wound site and generates a small amount of heat, thereby enabling the wound protected by the wound dressing to maintain an appropriate temperature and inhibit the activity of bacteria or viruses around the wound. Furthermore, similar to the aforementioned polyvinylpyrrolidone compound, it plays a role in mitigating toxicity and irritation caused by various toxins by binding with viruses, pigments, drugs, and chemicals.

[0027] The calcium chloride is included in the composition in an amount of 0.1 to 1 part by weight relative to 100 parts by weight of purified water. If the content of the calcium chloride is less than 0.1 parts by weight, the flexibility of the wound site may be reduced, whereas if the content of the calcium chloride exceeds 1 part by weight, skin irritation of the wound site may occur.

[0028] The above potassium sorbate is an ingredient capable of treating or preventing wounds or inflammation in the oral cavity, specifically performing the function of eliminating microorganisms in the oral cavity and promoting wound healing. The above potassium sorbate may have a liquid or gel formulation, and in this embodiment, the formulation of the potassium sorbate may be determined by considering overall adhesive performance and gel characteristics.

[0029] The potassium sorbate is included in the composition in an amount of 0.1 to 1 part by weight relative to 100 parts by weight of purified water. If the content of the potassium sorbate is less than 0.1 parts by weight, the rate of wound healing may be significantly reduced, whereas if the content of the potassium sorbate exceeds 1 part by weight, pain, inflammation, infection, allergic reaction, etc. may occur in the oral cavity.

[0030] The aforementioned propylene glycol is an organic alcohol component with a small molecular weight, making it easy to penetrate active ingredients into the skin. The propylene glycol forms a thin film on the wound site to reduce external irritation and promote healing. Additionally, the propylene glycol has the effect of eliminating microorganisms in the oral cavity and reducing inflammation.

[0031] The above propylene glycol is included in the composition in an amount of 1 to 3 parts by weight relative to 100 parts by weight of the above purified water. If the content of the above propylene glycol is less than 1 part by weight, a film is not formed at the wound site, so the core function of the wound dressing may not be expressed, whereas if the content exceeds 3 parts by weight, it may cause pain, inflammation, infection, allergic reaction, etc. in the oral cavity, similar to the potassium sorbate mentioned above.

[0032] The above EGF (Epidemal Growth Factor) liposome contains EGF (Epidemal Growth Factor) in small lipid beads called liposomes, which can promote wound healing and reduce scarring. The above EGF is a type of protein that performs the functions of healing and scar reduction. The liposome plays a role in stably protecting the EGF and penetrating it into the skin. The EGF liposome can also be manufactured in a liquid or gel form, and the formulation is determined by considering the degree of gelation of the entire composition. As the above EGF liposome, in this embodiment, Indilipo rh-EGF manufactured by SINA BT, an Indian new drug development company, may be used.

[0033] The above EGF liposomes are included in the composition in a trace amount of 0.05 to 0.2 parts by weight per 100 parts by weight of purified water. The content of the above EGF liposomes may be adjusted depending on the type or characteristics of the target wound.

[0034] The above-mentioned D-xylitol is generally known as a natural sweetener that provides a sweetness similar to sugar but has fewer calories and does not affect blood sugar levels. In this embodiment, the above-mentioned D-xylitol has the effect of inhibiting the growth and acid production of *Streptococcus mutans*, a cavity-causing bacterium in the oral cavity, and reducing the formation of dental plaque on the tooth surface. In addition, it can prevent the demineralization of tooth enamel and aid in the re-deposition of demineralized enamel.

[0035] The above D-xylitol may be included in the composition in an amount of 0.1 to 1 part by weight relative to 100 parts by weight of the above purified water.

[0036] Meanwhile, before the components in the above composition are mixed, basalt-derived ceramic powder can be immersed in the purified water and left for 1 to 2 days, after which the purified water containing the ceramic powder can be filtered and used. Through this, it was confirmed that the skin adhesion effect of the oral wound dressing composition can be increased and the bactericidal effect of the composition against bacteria on the skin can be improved.

[0037] FIG. 2 is an image of basalt-derived ceramic powder for pretreatment of purified water in a composition according to one embodiment of the present invention.

[0038] Referring to Figure 2, it can be seen that the basalt-derived ceramic powder exhibits a brownish color, unlike the black color of the original basalt.

[0039] The steps for manufacturing the above-mentioned basalt-derived ceramic powder will be explained in detail below.

[0040] FIG. 3 is a flowchart conceptually showing a method for manufacturing ceramic powder according to one embodiment of the present invention.

[0041] Referring to FIG. 3, in order to perform the method for manufacturing basalt-derived ceramic powder (S300), a basalt preparation and washing step (S310) is first performed to prepare and wash basalt. The basalt sample is a commercially available sample, and there are no specific restrictions on its shape. However, it is preferable not to purchase a powdered sample as the basalt sample in order to control the particle size in the subsequent crushing step. Washing is a measure to preemptively remove impurities present on the surface of the basalt so that they cannot act as factors that change the temperature in the subsequent melting step. Methods such as those utilizing differences in specific gravity may be used for the impurity removal method.

[0042] After the basalt is washed and dried, a basalt crushing step (S320) is performed. Through the crushing step (S320), crushed basalt is prepared, and it is desirable that the crushing be carried out so that the average particle size of the crushed material particles is maintained at approximately 0.1 mm to 0.5 mm. For melting efficiency, it is advantageous to crush the basalt more finely, but if the average particle size of the crushed particles is less than 0.1 mm, melting occurs too rapidly, making it difficult to achieve the full characteristics due to abnormal heat treatment. In the basalt crushing step (S320), foreign substances contained within the basalt and crushed are separated by various methods. This is because foreign substances can cause abnormal melting temperature in the melting step (S330) described later.

[0043] When the crushed basalt is prepared, a low-temperature melting step (S330) is performed to heat and melt the crushed basalt. The crushed basalt must be melted in a relatively low-temperature environment of 800 to 1000°C, rather than at a temperature of 1400°C or higher, which is the normal complete melting temperature, and by melting at the above temperature, the physical properties required for a reinforcing material can be achieved. Meanwhile, during the process of performing the melting step (S330), sulfur or an acidic solution may be added.

[0044] When the low-temperature melting step (S330) is completed, a cooling step (S340) for cooling the molten material is performed. The cooling is carried out sufficiently at room temperature. When the cooling step (S340) is completed, a pulverization step (S350) for pulverizing the cooled molten material is performed, thereby preparing a basalt-derived ceramic powder according to one embodiment of the present invention.

[0045] The above basalt-derived ceramic powder may be variably configured such that the composition of the ceramic powder has the following composition, depending on detailed melting temperature conditions or whether additives are added. Test results (Korea Institute of Materials Science) confirmed that the ceramic powder contains 100 parts by weight of SiO2; 25 to 32 parts by weight of Al2O3; 18 to 22 parts by weight of CaO; 18 to 22 parts by weight of MgO; 18 to 22 parts by weight of Fe2O3; and metallic components such as Ti, Y, La, Ce, and Nd.

[0046] Table 1 below is a table illustrating the composition of the ceramic powder above.

[0047] SiO2 Al2O3 CaO MgO Fe2O3 Ti Y La Ca Nd bal 15.33 10.19 10.07 10.18 1.19 0.0043 0.0095 0.0131 0.0071

[0048] The composition prepared as described above may further include additional functional additives.

[0049] Examples of the above additives include propolis extract, cranberry concentrate, Centella asiatica extract, hyaluronic acid, potassium diphosphate, magnesium chloride, lemon flavor, peppermint flavor, etc.

[0050] The above additives may include at least one of the additive components in a range of 0.1 to 3 parts by weight per 100 parts by weight of the purified water. Any one of the additive components may be included in the composition alone. Meanwhile, the above additives may include a plurality of combinations or all of the above additives.

[0051] The above propolis extract is a natural substance produced by honeybees mixing plant resin with their saliva, possesses antioxidant, antibacterial, and anti-inflammatory effects, and is included in an oral wound dressing composition to add the above functionalities to the composition.

[0052] The above cranberry concentrate is included in the composition and can reduce the amount of oral bacteria that cause plaque, and plays a role in preventing bacterial growth.

[0053] The above Centella asiatica extract, included in the composition, can aid in wound healing, and in particular, the component called madecassic acid within the extract can reduce inflammation of oral wounds and promote wound healing.

[0054] The hyaluronic acid mentioned above is included in the composition and serves to form a protective barrier on the mucous membrane, preventing wounds or injuries from coming into contact with food and beverages. In particular, the hyaluronic acid can help reduce inflammation and associated discomfort through its anti-inflammation effect and may also aid in treating stomatitis.

[0055] The above potassium monophosphate is included in the composition and can help alleviate oral inflammation and aid in wound healing by regulating the pH in the oral cavity.

[0056] The above magnesium chloride is included in the composition and can perform the role of maintaining a constant skin temperature at the wound site.

[0057] In addition to its basic role of refreshing the smell in the mouth, the above lemon flavoring can help alleviate oral inflammation and aid in wound healing by regulating the pH in the mouth, similar to the aforementioned potassium diphosphate.

[0058] The above-mentioned peppermint flavoring, like the lemon flavoring, serves to refresh the odor in the oral cavity. Meanwhile, the above-mentioned peppermint flavoring is an essential oil extracted from the leaves and flowers of the peppermint tree, which can exhibit antibacterial, anti-inflammatory, analgesic, and wound-healing effects, and can perform the additional function of preventing tooth decay and cleaning teeth by maintaining the pH in the oral cavity at an acidic level.

[0059] The specific compositions for the spray-type oral wound dressings described above are shown in Examples 1 and 2 and Tables 2 and 3 below. However, the following examples show specific examples of the compositions of the spray-type wound dressings, and the compositions below do not limit the technical scope of the present invention.

[0060] [Example]

[0061] Example 1

[0062] Ingredients List ratio Polyvinylpyrrolidone K-90 6.00% calcium chloride 0.60% Potassium sorbate 0.40% Propylene glycol 2.00% Indilipo rh-EGF 0.10% D-Xylitol 0.50% purified water 87.20% Propolis extract 0.50% Cranberry concentrate 0.50% Centella asiatica extract 0.50% Hyaluronic acid 0.20% potassium diphosphate 0.10% magnesium chloride 0.10% Lemon (scent) 0.50% Peppermint (scent) 0.80%

[0064] Example 2

[0065] Ingredients List ratio Polyvinylpyrrolidone K-90 6.00% calcium chloride 0.60% Potassium sorbate 0.40% Propylene glycol 2.00% Indilipo rh-EGF 0.10% D-Xylitol 0.50% Purified water (left for 24 hours after adding ceramic powder) 87.20% Propolis extract 0.50% Cranberry concentrate 0.50% Centella asiatica extract 0.50% Hyaluronic acid 0.20% potassium diphosphate 0.10% magnesium chloride 0.10% Lemon (scent) 0.50% Peppermint (scent) 0.80%

[0067] [evaluation]

[0068] Antimicrobial evaluation

[0069] One of the oral bacteria cultured Streptococcus mutans, and each of Example 1 and

[0070] The reduction rate was evaluated by comparing the initial number of bacteria and the number of bacteria after 3 hours following the spraying of the composition of 2. As a result, a reduction of approximately 27% in bacteria was confirmed when the composition of Example 1 was applied, and a reduction of approximately 34% in bacteria was confirmed when the composition of Example 2 was applied.

[0072] Anti-inflammatory evaluation

[0073] After creating a small artificial wound in the subject's mouth, the composition of Example 1 was applied, and then inflammatory markers were checked. It was confirmed that it reduced inflammatory cells and inflammatory mediators in the wound area over time.

[0075] It is expected that the manufactured spray-type oral wound dressing composition can be diversified into various detailed compositions by varying the viscosity and additives according to the type of oral wound.

Claims

Claim 1 100 parts by weight of purified water; 5 to 10 parts by weight of polyvinylpyrrolidone K90 as a polyvinylpyrrolidone compound; 0.1 to 1 part by weight of calcium chloride; 0.1 to 1 part by weight of potassium sorbate; 1 to 3 parts by weight of propylene glycol; 0.05 to 0.2 parts by weight of EGF (Epidemal Growth Factor) liposomes; 0.1 to 1 part by weight of D-xylitol; and comprises 0.1 to 3 parts by weight of at least one component selected from the group consisting of cranberry concentrate, potassium dihydrogen phosphate, magnesium chloride, lemon flavoring, and peppermint flavoring, and the purified water is filtered water obtained by leaving basalt-derived ceramic powder, which is produced by melting crushed basalt powder at a temperature of 800°C to 1000°C below the complete melting temperature and cooling it to powder, for 24 to 48 hours, and then filtering; the ceramic powder comprises, based on 100 parts by weight of silicon dioxide (SiO₂), 25 to 32 parts by weight of aluminum oxide (Al₂O₃), 18 to 22 parts by weight of calcium oxide (CaO), 18 to 22 parts by weight of magnesium oxide (MgO), and 18 to 22 parts by weight of iron oxide (Fe₂O₃), and is composed of titanium (Ti), yttrium (Y), lanthanum (La), cerium (Ce), and neodymium (Nd). A spray-type oral wound dressing composition comprising at least one metal component selected from the group consisting of Claim 2 delete Claim 3 A spray-type oral wound coating composition according to claim 1, characterized in that the EGF liposome is Indilipo rh-EGF (trade name). Claim 4 delete

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