Composition for relieving hangover and improving inflammation comprising natural product as effective ingredients

Abstract

A composition according to one aspect of the present invention lowers blood alcohol concentration and has an excellent effect in reducing the blood concentration of acetaldehyde, which causes hangovers and inflammation; thereby, excellent hangover relief and inflammation improvement effects can be expected. In addition, the composition of the present invention includes naturally derived substances rather than synthetic substances as active ingredients, so there are no side effects caused by synthetic substances.

Description

Technology Field

[0001] The present invention relates to a composition for relieving hangovers and / or improving inflammation, comprising natural materials such as Poria cocos, Atractylodes rhizome, Pogostemon cablin, Boswellia, Polygonum multiflorum, and Rhus verniciflua as active ingredients. Background Technology

[0002] Alcohol consumed through drinking is absorbed in the small intestine, travels through the bloodstream to the liver, and is broken down. During this process, alcohol is broken down into acetaldehyde by alcohol dehydrogenase or the microsomal ethanol oxidizing system (MEOS). Subsequently, acetaldehyde is converted into acetic acid and acetyl-CoA through metabolic processes and utilized for energy production and ketone body generation; however, acetaldehyde that is not rapidly metabolized primarily causes hangovers. Major symptoms of a hangover include headache, muscle pain, nausea, vomiting, dizziness, decreased concentration, dry mouth, fatigue, satiety, hyperactivity, irritability, depression, and sweating. There are numerous reported cases where individuals are unable to lead normal lives for periods ranging from a few hours to several days due to hangovers.

[0003] Accordingly, while various remedies have been developed over the years to alleviate hangovers caused by drinking, nothing is known yet that can quickly and effectively relieve hangover symptoms. Prior art literature

[0004] 10-2023-0085543 A The problem to be solved

[0005] In one aspect, the objective of the present invention is to obtain a hangover relief effect within a short period after administration.

[0006] In one aspect, the object of the present invention is to rapidly break down, remove, and / or expel acetaldehyde, a hangover-inducing substance, from the body.

[0007] In one aspect, the objective of the present invention is to block the mechanism of inflammation occurring in the body after alcohol consumption.

[0008] In one aspect, the objective of the present invention is to relieve a hangover without side effects caused by synthetic substances.

[0009] The object of the present invention is not limited to the technical problem as described above, and other technical problems may be derived from the following description. means of solving the problem

[0010] To achieve the above objective, a hangover relief composition is provided, wherein the hangover relief composition comprises a) Poria cocos, Atractylodes rhizome, and Pogostemon cablin; and b) one or more selected from the group consisting of Boswellia, Polygonum multiflorum, and Rhus verniciflua.

[0011] In addition, to achieve the above objective, the present invention provides an inflammation-improving composition, wherein the inflammation-improving composition comprises a) Poria cocos, Atractylodes rhizome, and Pogostemon cablin; and b) one or more selected from the group consisting of Boswellia, Polygonum multiflorum, and Rhus verniciflua.

[0012] In addition, to achieve the above objective, the present invention provides a composition for relieving hangovers or a composition for improving inflammation, wherein, when the above Poria cocos is 100 parts by weight, the above Atractylodes rhizome is 60 to 75 parts by weight and the above Pogostemon cablin is 60 to 75 parts by weight.

[0013] In addition, to achieve the above objective, the present invention provides a composition for relieving hangovers or a composition for improving inflammation, comprising 35 to 50 parts by weight of Boswellia, 50 to 65 parts by weight of Tobokryeong, and 35 to 50 parts by weight of Hwangchil tree, when the above Poria cocos is 100 parts by weight.

[0014] In addition, to achieve the above objective, the present invention provides a composition for relieving hangovers or improving inflammation, wherein the composition comprises Poria cocos, Atractylodes lanceolata, Pogostemon cablin, Boswellia, Polygonum multiflorum, and Rhus verniciflua, and is composed of 60 to 75 parts by weight of Atractylodes lanceolata, 60 to 75 parts by weight of Pogostemon cablin, 35 to 50 parts by weight of Boswellia, 50 to 65 parts by weight of Polygonum multiflorum, and 35 to 50 parts by weight of Rhus verniciflua, based on 100 parts by weight of Poria cocos.

[0015] In addition, to achieve the above objective, the present invention provides a composition for relieving hangovers or a composition for improving inflammation, wherein the composition comprises a composition for health functional foods.

[0016] In addition, to achieve the above objective, the present invention provides a composition for relieving a hangover, wherein the hangover relief comprises a reduction in blood alcohol concentration or a reduction in blood acetaldehyde concentration. Effects of the invention

[0017] A composition according to one aspect of the present invention is effective in lowering blood alcohol concentration.

[0018] In addition, a composition according to one aspect of the present invention can be expected to have excellent hangover relief and inflammation improvement effects by improving the efficiency of decomposition in the body of acetaldehyde, which is a decomposition product of alcohol and causes hangovers and inflammation, thereby lowering its blood concentration.

[0019] In addition, a composition according to one aspect of the present invention includes a naturally derived substance rather than a synthetic substance as an active ingredient, so there are no side effects caused by synthetic substances.

[0020] The effects of the present invention are not limited to those mentioned above, and other unmentioned effects will be clearly understood by those skilled in the art from the description below. Specific details for implementing the invention

[0021] The present invention will be described in detail below.

[0022] The following description is merely an example, and the scope of the present invention is not limited by the following.

[0023] Furthermore, terms or words used in the specification and claims of the present invention are not limited to their ordinary or dictionary meanings, and must be interpreted in a meaning and concept consistent with the technical spirit of the present invention, based on the principle that the inventor can appropriately define the concept of the terms to best describe his invention.

[0024] Throughout the specification of the present invention, when a part is described as “comprising” a certain component, this means that, unless specifically stated otherwise, it does not exclude other components but may include additional components.

[0025] Throughout the specification of the present invention, “A and / or B” means A or B, or A and B.

[0026] The above Poria cocos ( Wolfiporia extensa) Poria cocos refers to the sclerotia that parasitize and grow on the roots of pine trees more than three years after felling. Because Poria cocos generally exhibits irregular shapes, it is very difficult to obtain naturally; therefore, it is sometimes grown artificially by cutting the roots into pieces and injecting the mycelium. Those with a pine root in the center are called Boksin, and the outer bark is called Bokryeongpi; those with a pale pink interior are called Jeokbokryeong, and only the white part obtained by slicing Jeokbokryeong is called Baekbokryeong. Poria cocos is often utilized entirely, from the outer bark to the interior, without any part being discarded.

[0027] The above creation ( Atractylodes lancea ) refers to the dried roots of plants such as *Atractylodes macrocephala* and *Atractylodes manshuriensis*, which belong to the family Asteraceae in the order Campanulales of dicotyledonous plants, and are used as is without peeling the skin off the thick roots.

[0028] The above-mentioned Atractylodes may be included in an amount of 60 to 75 parts by weight, 62 to 73 parts by weight, 64 to 71 parts by weight, or 66 to 68 parts by weight, based on 100 parts by weight of Poria cocos.

[0029] More specifically, the above-mentioned atractylodes may be included in an amount of 60 parts by weight or more, 61 parts by weight or more, 62 parts by weight or more, 63 parts by weight or more, 64 parts by weight or more, 65 parts by weight or more, or 66 parts by weight or more, or 75 parts by weight or less, 74 parts by weight or less, 73 parts by weight or less, 72 parts by weight or less, 71 parts by weight or less, 70 parts by weight or less, 69 parts by weight or less, or 68 parts by weight or less, based on 100 parts by weight of Poria cocos.

[0030] The above-mentioned pagoda tree ( Teucrium veronicoides Maxima japonica is a perennial herb that grows in moist areas. The stem grows upright, reaching a height of 10–25 cm, and is covered with spreading hairs. The leaves are opposite; the leaf blade is ovate or broadly ovate, measuring 2.5–4 cm in length and 1.5–2.5 cm in width, with a somewhat blunt tip and a broad wedge-shaped base, and the margin is serrated. The petiole is 1–2 cm long. Flowers bloom in July and August; the calyx has glandular hairs on the upper part, faces downward when the fruit sets, and is light brown. The corolla is light purple and hairless. The fruit is a small, round capsule that ripens in August and September. It is mainly native to Gyeongsangnam-do and Jeju Island in Korea, and is also known to be distributed in Japan.

[0031] The above-mentioned Pogostemon cablin may be included in an amount of 60 to 75 parts by weight, 62 to 73 parts by weight, 64 to 71 parts by weight, or 66 to 68 parts by weight, based on 100 parts by weight of Poria cocos.

[0032] ​More specifically, the above-mentioned Pogostemon cablin may be included in an amount of 60 parts by weight or more, 61 parts by weight or more, 62 parts by weight or more, 63 parts by weight or more, 64 parts by weight or more, 65 parts by weight or more, or 66 parts by weight or more, or 75 parts by weight or less, 74 parts by weight or less, 73 parts by weight or less, 72 parts by weight or less, 71 parts by weight or less, 70 parts by weight or less, 69 parts by weight or less, or 68 parts by weight or less, based on 100 parts by weight of Poria cocos.

[0033] The above Boswellia ( Boswellia sacra Boswellia, also known as frankincense, is the dried sap collected from frankincense trees distributed in the alpine regions of India, Pakistan, and Africa. The tree is incised with a sharp object such as a knife, allowing the first sap to flow out, and then further incisions are made to collect the resulting sap for about two weeks. The darker the green color, the higher the quality is considered; Boswellia ranging from yellow to silver is considered superior, while Boswellia with a yellowish-brown color is yellowish-brown.

[0034] The above Boswellia may be included in an amount of 35 to 50 parts by weight, 37 to 48 parts by weight, 39 to 46 parts by weight, or 41 to 43 parts by weight, based on 100 parts by weight of Poria cocos.

[0035] More specifically, the above Boswellia may be included in an amount of 35 parts by weight or more, 36 parts by weight or more, 37 parts by weight or more, 38 parts by weight or more, 39 parts by weight or more, 40 parts by weight or more, or 41 parts by weight or more, or 50 parts by weight or less, 49 parts by weight or less, 48 ​​parts by weight or less, 47 parts by weight or less, 46 parts by weight or less, 45 parts by weight or less, 44 parts by weight or less, or 43 parts by weight or less, based on 100 parts by weight of Poria cocos.

[0036] The above Tobokryeong ( Smilax glabraTobokryeong refers to the dried rhizome of the Smilax china plant. Since the plant is also called "manggae tree" in the Gyeongsang region, Tobokryeong is sometimes referred to as "manggae tree root." It was given the name Tobokryeong because it resembles the Poria cocos that grows on pine tree roots. The leaves of the Smilax china plant are broad and egg-shaped, making them suitable for wrapping manggae tteok (rice cakes). The flowers are yellowish-green and bloom in May, while the red fruits that ripen around September and October are also edible.

[0037] The above-mentioned Tobokryeong may be included in an amount of 50 to 65 parts by weight, 52 to 63 parts by weight, 54 to 61 parts by weight, or 57 to 59 parts by weight, based on 100 parts by weight of Poria cocos.

[0038] More specifically, the above-mentioned *Tobokryeong* may be included in an amount of 50 parts by weight or more, 51 parts by weight or more, 52 parts by weight or more, 53 parts by weight or more, 54 parts by weight or more, 55 parts by weight or more, 56 parts by weight or more, or 57 parts by weight or more, or 65 parts by weight or less, 64 parts by weight or less, 63 parts by weight or less, 62 parts by weight or less, 61 parts by weight or less, 60 parts by weight or less, or 59 parts by weight or less, based on 100 parts by weight of *Bokryeong*.

[0039] The above yellow lacquer tree ( Dendropanax morbiferus It is a plant belonging to the Araliaceae family, a tall tree that grows up to about 15 meters in height with evergreen leaves. As a tropical tree, it has poor cold tolerance and grows naturally in limited areas such as southern coastal regions like Wando, Haenam, and Jeju Island.

[0040] The above-mentioned Rhus verniciflua may be included in an amount of 35 to 50 parts by weight, 37 to 48 parts by weight, 39 to 46 parts by weight, or 41 to 43 parts by weight, based on 100 parts by weight of Poria cocos.

[0041] More specifically, the above-mentioned Rhus verniciflua may be included in an amount of 35 parts by weight or more, 36 parts by weight or more, 37 parts by weight or more, 38 parts by weight or more, 39 parts by weight or more, 40 parts by weight or more, or 41 parts by weight or more, or 50 parts by weight or less, 49 parts by weight or less, 48 ​​parts by weight or less, 47 parts by weight or less, 46 parts by weight or less, 45 parts by weight or less, 44 parts by weight or less, or 43 parts by weight or less, based on 100 parts by weight of Poria cocos.

[0042] In this specification, the term “extract” encompasses all substances obtained by extracting components of natural products, regardless of the extraction method, extraction solvent, extracted components, or the form of the extract. Furthermore, it is a broad concept that includes all substances that can be obtained by processing or treating the substance obtained by extracting components of natural products through other methods after extraction; specifically, such processing or treatment may involve additionally fermenting or enzymatically treating the extract. Therefore, in this specification, the term “extract” is a broad concept that includes fermented products, concentrates, and dried products.

[0043] For example, extraction methods for extracts may include solvent extraction, ultrasonic extraction, distillation extraction, pressing extraction, high-pressure extraction, or supercritical extraction.

[0044] In the above aspects, the extraction solvent of the extract may include water, an organic solvent, or a mixture thereof.

[0045] The above organic solvent may include hexane, methylene chloride, alcohol, etc., but is not limited thereto. In the above, water includes distilled water or purified water, and the organic solvent includes one or more selected from the group consisting of methanol, ethanol, n-propanol, isopropanol, ethylene glycol, 1,2-propanediol, 1,2-butanediol, glycerol, etc., which are examples of lower alcohols having C1 to C5, but is not limited thereto.

[0046] When the above extraction solvent is water, heat extraction, cold maceration extraction, reflux cooling extraction, or ultrasonic extraction may be used, and preferably, heat extraction using hot water may be used, and preferably, extraction may be performed at a temperature of about 40 to 120°C, more preferably 90 to 100°C, specifically about 100°C, but is not limited thereto.

[0047] In one embodiment, the organic solvent may be an alcohol, and the alcohol may be ethanol.

[0048] The concentration of the above alcohol may be 10 to 99% (w / w), or 20 to 99% (w / w), or 30 to 80% (w / w), or 40 to 80% (w / w), or 40 to 80% (w / w), or 50 to 80% (w / w), and preferably 60 to 80% (w / w).

[0049] In one aspect, the present invention may include a food composition.

[0050] The above food composition may include a health functional food. A health functional food is a food manufactured using nutrients that are easily deficient in daily meals or raw materials or ingredients (functional ingredients) that have functions useful to the human body, and may refer to a food that maintains normal human functions or maintains and improves health through the activation of physiological functions, but is not limited thereto. The above health food may be manufactured or processed in the form of tablets, capsules, powders, granules, liquids, pills, etc., but is not limited thereto, and may be manufactured or processed in any form in accordance with the law.

[0051] The mixture of active ingredients can be appropriately determined according to the purpose of use (prevention, health, or therapeutic treatment).

[0052] In a food composition according to one aspect of the present invention, the composition may be included in an amount of 0.1 to 100% (ww) based on the total weight. For example, it may be included in an amount of 1 to 90%, or 1 to 80%, or 1 to 70%, or 1 to 60%, or 1 to 50%, or 1 to 40%, or 1 to 30%, or 1 to 20%, or 1 to 10%, etc. based on the weight of the composition, and this may be adjusted to obtain the desired effect depending on the formulation, type of product, etc.

[0053] The composition prepared according to the formulation may be added to the following foods, for example, beverages, sauces, confectionery, bread, grain products, meat products, dairy products, powdered beverages, powdered seasonings, health supplements, processed foods, chewing gum, candies, etc.

[0054] In addition, the above food composition may further contain vitamins, minerals, dietary fiber, flavoring agents, sweeteners, flavorings, coloring agents, flavoring agents, thickeners, preservatives, antioxidants, stabilizers, etc.

[0055] In one aspect, the present invention may include a) Poria cocos, Atractylodes rhizome, and Pogostemon cablin, and b) one or more selected from Boswellia, Polygonum multiflorum, and Rhus verniciflua.

[0056] In one embodiment, when the composition of the present invention includes a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin and b) Boswellia, it may exhibit improved hangover relief and inflammation improvement effects compared to when it includes only a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin.

[0057] In one embodiment, when the composition of the present invention includes a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin and b) Boswellia, it may exhibit improved hangover relief and inflammation improvement effects compared to when it includes only one substance selected from a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin and b) Polygonum multiflorum and Rhus verniciflua.

[0058] In one embodiment, when the composition of the present invention includes a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin and b) Poria cocos, it may exhibit improved hangover relief and inflammation improvement effects compared to when it includes only a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin.

[0059] In one embodiment, when the composition of the present invention includes a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin and b) Polygonum multiflorum, it may exhibit improved hangover relief and inflammation improvement effects compared to when it includes a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin and b) Rhus verniciflua.

[0060] In one embodiment, when the composition of the present invention includes a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin and b) Rhus verniciflua, it may exhibit improved hangover relief and inflammation improvement effects compared to when it includes only a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin.

[0061] In one embodiment, when the composition of the present invention includes a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin and b) Boswellia and Polygonum multiflorum, it may exhibit improved hangover relief and inflammation improvement effects compared to when it includes only one selected substance among a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin and b) Boswellia and Polygonum multiflorum.

[0062] In one embodiment, when the composition of the present invention includes a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin and b) Polygonum multiflorum and Rhus verniciflua, it may exhibit improved hangover relief and inflammation improvement effects compared to when it includes only one selected substance among a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin and b) Polygonum multiflorum and Rhus verniciflua.

[0063] In one embodiment, when the composition of the present invention includes a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin and b) Boswellia and Rhus verniciflua, it may exhibit improved hangover relief and inflammation improvement effects compared to when it includes only one selected substance among a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin and b) Boswellia and Rhus verniciflua.

[0064] In one embodiment, when the composition of the present invention comprises a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin and b) Boswellia, Polygonum multiflorum, and Rhus verniciflua, it may exhibit improved hangover relief and inflammation improvement effects compared to when it comprises only two selected substances among a) Poria cocos, Atractylodes lanceolata, and Pogostemon cablin and b) Boswellia, Polygonum multiflorum, and Rhus verniciflua.

[0066] [Preparation Example]

[0067] [Preparation Example 1]

[0068] To confirm the hangover relief and inflammation-improving effects of Poria cocos, Atractylodes rhizome, Pogostemon cablin, Boswellia, Polygonum multiflorum, and Rhus verniciflua, each ingredient was thoroughly washed, chopped, and powdered for extraction. Then, distilled water equivalent to 10 times the amount of the ingredient was added per 100g of the ingredient, heated at 95°C to 100°C for 1 hour, and filtered using a vacuum filtration device to obtain the extracts. To confirm the difference in effects depending on the presence or absence of the ingredients, combinations of each obtained extract were prepared as follows.

[0069] ingredient a b Poria creation Gwakhyang Boswellia Tobokryeong Hwangchil tree Control group (a) O O O X X X 1 O O O O X X 2 O O O X O X 3 O O O X X O 4 O O O O O X 5 O O O O X O 6 O O O X O O 7 O O O O O O

[0070] [Experimental Example]

[0071] [Experimental Example 1] Evaluation of the effect of reducing blood alcohol and blood acetaldehyde concentrations

[0072] To determine the rate of decrease in blood alcohol and acetaldehyde concentrations after alcohol administration, Wistar rats (male, 5 weeks old) were acclimatized by feeding them regular feed for 1 week, and then 10 ml of alcohol was administered to rats that had been fasted for 12 hours. After 30 minutes, 50 ml of the composition according to [Table 2] was administered. Blood was collected from the tails 30 minutes, 1 hour, 3 hours, and 5 hours after alcohol administration, and blood alcohol and acetaldehyde concentrations were analyzed.

[0074] As can be seen in Table 2, the results of the experiment on the effect of reducing blood alcohol concentration showed that, first, blood alcohol concentration increased in all groups without significant difference up to 30 minutes and 1 hour after alcohol intake, indicating that up to 1 hour after alcohol administration is a stage of alcohol absorption.

[0075] The control group (a) showed 59 mg / dl 3 hours after alcohol administration and 43 mg / dl 5 hours after administration, confirming that the blood alcohol concentration gradually decreased.

[0076] According to the results of experiments 1 to 3, in which component b was included alone, it was confirmed that the blood alcohol concentration after 3 hours was 45 mg / dl, 47 mg / dl, and 50 mg / dl, respectively, and after 5 hours was 33 mg / dl, 35 mg / dl, and 39 mg / dl, respectively. The blood alcohol concentration reduction effect was excellent compared to the control group, and the blood alcohol concentration reduction effect was excellent in the order of Boswellia, Smilax china, and Rhus verniciflua, which are components of b.

[0077] According to the results of experiments 4–6 containing two components of b, it was confirmed that the blood alcohol concentration after 3 hours was 30 mg / dl, 32 mg / dl, and 36 mg / dl, respectively, and after 5 hours was 24 mg / dl, 27 mg / dl, and 31 mg / dl, respectively. The blood alcohol concentration reduction effect was superior compared to the control group and the single component of b, and the blood alcohol concentration reduction effect was superior in the order of Boswellia + Tobokryeong, Boswellia + Hwangchil tree, and Tobokryeong + Hwangchil tree.

[0078] According to the experimental results of 7 containing three components of b, the blood alcohol concentration after 3 hours was 22 mg / dl and after 5 hours was 19 mg / dl, confirming that the most excellent blood alcohol concentration reduction effect was observed.

[0079] division After 30 minutes (mg / dl) 1 hour later (mg / dl) 3 hours later (mg / dl) 5 hours later (mg / dl) Control group (a) 62 83 59 43 1 61 87 45 33 2 65 89 47 35 3 69 84 52 39 4 63 89 30 24 5 64 76 32 27 6 64 86 36 31 7 65 84 22 19

[0081] [Effect of reducing blood acetaldehyde concentration]

[0082] As can be seen in Table 3 below regarding the experimental results on the effect of reducing blood acetaldehyde concentration, it was found that blood acetaldehyde concentration increased in all groups without significant difference up to 30 minutes and 1 hour after alcohol consumption, indicating that up to 1 hour after alcohol administration is a stage where alcohol is absorbed and acetaldehyde is produced.

[0083] The control group (a) showed 55 µg / dl 3 hours after alcohol administration and 46 µg / dl 5 hours after administration, confirming that the blood acetaldehyde concentration gradually decreased.

[0084] According to the results of experiments 1 to 3, in which component b was included alone, it was confirmed that blood acetaldehyde concentrations after 3 hours were 48 µg / dl, 49 µg / dl, and 51 µg / dl, respectively, and after 5 hours were 41 µg / dl, 43 µg / dl, and 44 µg / dl, respectively. The effect of reducing blood acetaldehyde concentration was excellent compared to the control group, and the effect of reducing blood acetaldehyde concentration was excellent in the order of Boswellia, Smilax china, and Rhus verniciflua, which are components of b.

[0085] According to the results of experiments 4–6 containing two components of b, it was confirmed that blood acetaldehyde concentrations after 3 hours were 40 µg / dl, 43 µg / dl, and 45 µg / dl, respectively, and after 5 hours were 32 µg / dl, 36 µg / dl, and 39 µg / dl, respectively. The effect on blood acetaldehyde concentration was superior compared to the control group and the single component of b, and the reduction effect on blood acetaldehyde concentration was superior in the order of Boswellia + Tobokryeong, Boswellia + Hwangchilnamu, and Tobokryeong + Hwangchilnamu.

[0086] According to the experimental results of 7, which included three components of b, the blood acetaldehyde concentration after 3 hours was 31 μg / dl and after 5 hours was 24 μg / dl, confirming that the most excellent blood acetaldehyde concentration reduction effect was observed.

[0087] division After 30 minutes (µg / dl) After 1 hour (µg / dl) After 3 hours (µg / dl) After 5 hours (µg / dl) control group 52 69 55 46 1 56 73 48 41 2 54 71 49 43 3 58 74 51 44 4 53 72 40 32 5 51 71 43 36 6 59 73 45 39 7 54 71 31 24

[0089] [Experimental Example 2] Evaluation of Inflammation Improvement

[0090] RAW264.7 cells were seeded into a 96-well plate and cultured for 12 hours, then each composition of [Table 1] was added, followed by treatment with LPS and culture for 24 hours. The concentrations of inflammatory cytokines were measured using an ELISA Cytockine Kit containing TNF-α and IL-6.

[0091] division TNF-α(pg / ml) IL-6(pg / ml) Control 423 121 Control group (a) 2876 425 1 2456 384 2 2346 388 3 2234 402 4 1864 320 5 1823 361 6 1726 342 7 1243 168

[0092] According to the results of [Table 4], TNF-α and IL-6 factors were slightly reduced in 1 to 3 compared to the control group (a), and TNF-α and IL-6 were further reduced in 4 to 6 compared to the previous compositions. It was confirmed that 7, which is a combination of all components, showed the best reduction rate of TNF-α and IL-6.

[0094] [Experimental Example 3] Evaluation of the degree of hangover symptom relief

[0095] A hangover relief test was performed on 20 men of various age groups (5 in their 20s, 5 in their 30s, 5 in their 40s, and 5 in their 50s) regarding the items listed in Table 5 below. After classifying the experimental groups based on symptoms by confirming the hangover symptoms that usually occur after drinking, the hangover relief effect was confirmed by checking the degree of hangover symptoms after consuming 100ml of each composition immediately after drinking twice a week for a total of 4 weeks, taking into account the health of the subjects.

[0097] symptoms Vomiting (name) Headache (name) Abdominal pain (name) Fatigue (noun) Muscle pain (name) Thirst (noun) Chest pain (name) Traditional hangover symptoms 14 16 13 9 6 5 6 Control group (a) 10 12 10 6 4 4 4 1 7 9 9 6 4 3 3 2 8 10 9 4 2 4 3 3 8 11 7 5 3 4 4 4 5 6 8 5 2 2 2 5 5 7 6 4 3 3 3 6 7 8 5 3 2 3 3 7 3 3 4 2 1 1 1

[0098] The participants' hangover symptoms were assessed based on the results derived from multiple responses, after having them check all individual hangover symptoms.

[0099] It was confirmed that the most frequently manifested hangover symptom among the subjects was headache, and that gastrointestinal disorders such as vomiting and abdominal pain, as well as systemic symptoms such as fatigue and muscle pain, were also not uncommon.

[0100] It was confirmed that the control group (a) and the subjects who consumed 1 to 7 answered that their hangover symptoms improved overall.

[0101] It was confirmed that in the experimental group containing Boswellia (1, 4, 5, 7), vomiting symptoms were improved compared to other experimental groups.

[0102] It was confirmed that in the experimental group (2, 4, 6, 7) containing Tobokryeong, muscle pain symptoms were improved compared to other experimental groups.

[0103] It was confirmed that in the experimental group (3, 5, 6, 7) containing Hwangchil tree, abdominal pain symptoms improved compared to other experimental groups.

[0104] It was confirmed that the experimental group (7) containing Boswellia, Tobokryeong, and Hwangchil tree showed improvement in overall hangover symptoms compared to other experimental groups.

[0106] [Experimental Example 4] Sensory Evaluation

[0107] Taste and preference evaluations based on compositional ingredient ratios were performed on 20 men of various age groups (5 in their 20s, 5 in their 30s, 5 in their 40s, and 5 in their 50s). The average value of the total evaluation scores was determined based on a 10-point scale, and the compositional ingredient ratios were evaluated as shown in [Table 6].

[0108] ingredient a (weight part) b (weight part) Poria creation Gwakhyang Boswellia Tobokryeong Hwangchil tree 1-1 100 55 67 42 58 42 1-2 100 60 67 42 58 42 1-3 100 75 67 42 58 42 1-4 100 80 67 42 58 42 2-1 100 67 55 42 58 42 2-2 100 67 60 42 58 42 2-3 100 67 75 42 58 42 2-4 100 67 80 42 58 42 3-1 100 67 67 30 58 42 3-2 100 67 67 35 58 42 3-3 100 67 67 50 58 42 3-4 100 67 67 55 58 42 4-1 100 67 67 42 45 42 4-2 100 67 67 42 50 42 4-3 100 67 67 42 65 42 4-4 100 67 67 42 70 42 5-1 100 67 67 42 58 30 5-2 100 67 67 42 58 35 5-3 100 67 67 42 58 50 5-4 100 67 67 42 58 55

[0110] division Taste (score) Scent (score) 1-1 7.6 6.8 1-2 9.2 8.2 1-3 9.1 9.3 1-4 7.9 7.3 2-1 8.1 7.0 2-2 9.0 8.9 2-3 9.6 9.1 2-4 8.0 7.5 3-1 7.6 7.4 3-2 9.6 9.3 3-3 9.1 9.3 3-4 8.3 7.9 4-1 7.9 8.0 4-2 9.3 9.6 4-3 9.3 9.7 4-4 8.1 8.2 5-1 7.8 7.9 5-2 8.6 8.5 5-3 9.0 9.0 5-4 6.9 6.7

[0111] As shown in the results of [Table 7], according to experiments 1-1 to 1-4 based on 100 parts by weight of Poria cocos, it was confirmed that the taste and aroma were excellent when the content of Atractylodes lanceolata was 60 to 75 parts by weight.

[0112] According to experiments 2-1 to 2-4 based on 100 parts by weight of Poria cocos, it was confirmed that the taste and aroma were excellent when the content of Poria cocos was 60 to 75 parts by weight.

[0113] According to experiments 3-1 to 3-4 based on 100 parts by weight of Poria cocos, it was confirmed that the taste and aroma are excellent when the Boswellia content is 35 to 50 parts by weight.

[0114] According to experiments 4-1 to 4-4 based on 100 parts by weight of Poria cocos, it was confirmed that the taste and aroma were excellent when the content of Tobokryeong was 50 to 65 parts by weight.

[0115] According to experiments 5-1 to 5-4 based on 100 parts by weight of Poria cocos, it was confirmed that the taste and aroma were excellent when the content of Rhus verniciflua was 35 to 50 parts by weight.

Claims

Claim 1 As a composition for relieving hangovers, the above-mentioned composition for relieving hangovers comprises: a) Poria cocos ( Wolfiporia extensa) , creation( Atractylodes lancea ), and Gwakhyang ( Teucrium veronicoides Maxim); and b) Boswellia ( Boswellia sacra Tobokryeong( Smilax glabra roxb); and yellow lacquer tree ( Dendropanax morbiferus A composition for relieving hangovers comprising two or more selected from the group consisting of ).​ Claim 2 delete Claim 3 A composition according to claim 1, wherein, when the above Poria cocos is 100 parts by weight, it comprises 60 to 75 parts by weight of Atractylodes rhizome and 60 to 75 parts by weight of Pogostemon cablin. Claim 4 A composition according to claim 1, wherein, when the above Poria cocos is 100 parts by weight, it comprises 35 to 50 parts by weight of Boswellia, 50 to 65 parts by weight of Smilax china, and 35 to 50 parts by weight of Rhus verniciflua. Claim 5 The composition according to claim 1 comprises Poria cocos, Atractylodes lanceolata, Pogostemon cablin, Boswellia, Polygonum multiflorum, and Rhus verniciflua, wherein, based on 100 parts by weight of Poria cocos, the composition comprises 60 to 75 parts by weight of Atractylodes lanceolata, 60 to 75 parts by weight of Pogostemon cablin, 35 to 50 parts by weight of Boswellia, 50 to 65 parts by weight of Polygonum multiflorum, and 35 to 50 parts by weight of Rhus verniciflua. Claim 6 A composition according to claim 1, wherein the hangover relief comprises a reduction in blood alcohol concentration or a reduction in blood acetaldehyde concentration. Claim 7 In claim 1, the composition comprises a composition for health functional foods.