Single-chain trail-receptor agonist proteins

MA39770AUndetermined Publication Date: 2015-10-29ABBVIE INC +1

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Patent Information

Application Number: MA39770
Authority / Receiving Office: MA · MA
Patent Type: Applications
Current Assignee / Owner
Priority Date: 2014-04-23
Filing Date: 2015-04-23
Publication Date: 2015-10-29

Application Information

Patent Timeline

23 Apr 2014

Priority

23 Apr 2015

Application

MA39770

29 Oct 2015

Publication

MA39770A

IPC: A61K38/00; A61K38/19; C07K14/705

CPC: C07K14/70575; A61K38/00; C07K2319/30; C07K2319/00; A61P19/02; A61P25/00; A61P25/28; A61P29/00

Inventors: BUCHANAN Fritz G.; GIEFFERS Christian

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Abstract

Provided herein are specific trail receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a trail-associated disease or disorder. The trail receptor agonist proteins provided herein comprise three soluble trail domains and an fc fragment. The trail receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and / or research applications.

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