Nucleic acid vaccines

Abstract

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (navs) comprising polynucleotide molecules encoding one or more antigens.

Description

FIELD OF THE INVENTION

[0001] The invention relates to vaccines, specifically nucleic acid vaccines (NAVs). In particular, the invention relates to ribonucleic acid (RNA) vaccines, i.e, mRNA vaccines.BACKGROUND OF THE INVENTION

[0002] Vaccination is an effective way to provide phrophylactic protection against infectious diseases, including, but not limited to, viral, bacterial, and / or parasitic diseases, such as influenza, AIDS, hepatotisis virus infection, cholera, malaria and tuberculosis, and many other diseases. For example, influenza infections are the seventh leading cause of death in the United States with 200, 000 hospitalizations and 40,000 deaths seen in the United States per year and cause about 3-5 million hospitalizations and about 300,000 to 500,000 deaths worldwide per year. Millions of people receive flu vaccines to protect them from seasonal flu each year. Vaccination can also rapidly prevent the spread of an emerging influenze pandemic.

[0003] A typical vaccine contains an agent that resembles a weakened or dead form of the disease-causing agent, which could be a microorganism, such as bacteria, virus, fungi, parasites, or one or more toxins and / or one or more proteins, for example, surface proteins, (i.e., antigens) of such a microorganism. The antigen or agent in the vaccine can stimulate the body's immune system to recognize the agent as a foreign invader, generate antibodies against it, destroy it and develop a memory of it. The vaccine-induced memory enables the immune system to act quickly to protect the body from any of these agents that it later encounters.

[0004] Vaccine production used in the art e.g., antigen vaccine production, has several stages, including the generation of antigens, antigen purification and inactivation, and vaccine formulation. First, the antigen is generated through culturing viruses in cell lines, growing bacteria in bioreactors, or producing recombinant proteins derived from viruses and bacteria in cell cultures, yeast or bacteria. Recombinant proteins are then purified and the viruses and bacteria are inactivated before they are formulated with adjuvants in vaccines. It has been a challenge to drastically reduce the time and expense associated with current technologies in vaccine development.

[0005] Another obstacle to the development of new vaccine is the constant evolution of most infectious agents, such as viruses and bacteria. Viruses often mutate their surface proteins to generate new antigens which can help them skipping the active immune system that has been immunized by vaccines containing the viruses. In contrast, bacteria acquire and mutate key proteins to evade host defense and effective antibiotic applications.

[0006] For example, influenza A, B and C viruses are the etiological agents of influenza. Hemagglutinin (HA) , the major envelop glycoprotein of influenza A and B viruses, or its homologue, hemagglutinin-esterase (HE) in influenza C virus, is the natural reservoir of the viruses. The rapid evolution of the hemagglutinin (HA) protein of the influenza virus results in the constant emergence of new strains, rendering the adaptive immune response of the host only partially protective to new infections. The biggest challenge for therapy and prophylaxis against influenza and other infections using traditional vaccines is the limitation of vaccines in breadth, providing protection only against closely related subtypes. In addition, today's length of the production process inhibits any fast reaction to develop and produce an adapted vaccine in a pandemic situation.

[0007] It is of great interest to develop new vaccines as well as new approaches to combatting infectious disease and infectious agents.SUMMARY OF THE INVENTION

[0008] Based on the disclosure that is contained herein, the present invention provides a nucleic acid vaccine, comprising: one or more mRNA polynucleotides having an open reading frame encoding an antigenic polypeptide, wherein the one or more mRNA polynucleotides comprise at least one chemical modification and are formulated in a lipid nanoparticle having a molar ratio of 20-60% cationic lipid: 5-25% non-cationic lipid: 25-55% sterol; and 0.5-15% PEG-modified lipid, wherein the at least one chemical modification is selected from the group consisting of pseudouridine, N1-methylpseudouridine, 2-thiouridine, 4-thiouridine, 5-methylcytosine, 2-thio-1-methyl-1-deaza-pseudouridine, 2-thio-1-methyl-pseudouridine, 2-thio-5-aza-uridine , 2-thio-dihydropseudouridine, 2-thio-dihydrouridine, 2-thio-pseudouridine, 4-methoxy-2-thio-pseudouridine, 4-methoxy-pseudouridine, 4-thio-1-methyl-pseudouridine, 4-thio-pseudouridine, 5-aza-uridine, dihydropseudouridine, 5-methoxyuridine, 2'-O-methyl uridine, 1-carboxymethyl-pseudouridine, 1-propynyl-pseudouridine, 1-taurinomethyl-pseudouridine, 1-taurinomethyl-4-thio-pseudouridine, 3-methyl-pseudouridine (m 3< ψ), 1-methyl-1-deaza-pseudouridine, 2-methoxyuridine, 2-methoxy-4- thio-uridine, 1-methyl-3-(3-amino-3-carboxypropyl)pseudouridine (acp 3< ψ), and 2'-O-methyl-pseudouridine (ψm), wherein the antigenic polypeptide is derived from an infectious agent, wherein the infectious agent is a strain of Influenza A or Influenza B or combinations thereof, and wherein the antigenic polypeptide is a hemagglutinin protein or fragment thereof.

[0009] In a further aspect, the present invention provides said vaccine for use in a method of inducing an antigen specific immune response in a subject, the method comprising administering the vaccine to the subject in an effective amount to produce an antigen specific immune response.

[0010] In yet another aspect, the present invention provides said vaccine for use in a method of preventing or treating influenza viral infection, the method comprising administering the vaccine to a subject.

[0011] The present invention and some preferred embodiments thereof are set out in the appended claims.

[0012] In some embodiments, the cationic lipid nanoparticle comprises a molar ratio of about 50% cationic lipid, about 1.5% PEG-modified lipid, about 38.5% cholesterol and about 10% non-cationic lipid. In some embodiments, the cationic lipid nanoparticle comprises a molar ratio of about 55% cationic lipid, about 2.5% PEG lipid, about 32.5% cholesterol and about 10% non-cationic lipid. In some embodiments,the cationic lipid is an ionizable cationic lipid and the non-cationic lipid is a neutral lipid, and the sterol is a cholesterol. In some embodiments, the cationic lipid nanoparticle has a molar ratio of 50:38.5:10:1.5 of cationic lipid: cholesterol: PEG2000-DMG:DSPC.

[0013] In some embodiments, the cationic lipid nanoparticle has a mean diameter of 50-150 nm. In some embodiments, the cationic lipid nanoparticle has a mean diameter of 80-100 nm. In some embodiments, the vaccine includes 1.5mg / mL of RNA polynucleotide and 35-45 mg / mL lipids. In some embodiments, the NAV includes about 2 mg / mL of RNA polynucleotide and about 40 mg / mL lipids.

[0014] In some embodiments, the open reading frame is codon-optimized.

[0015] In some embodiments, the one or more RNA polynucleotides encode a further antigenic polypeptide. In some embodiments, the further RNA polynucleotide comprises at least one chemical modification and a codon-optimized open reading frame, said open reading frame encoding an antigenic polypeptide.

[0016] In the invention, the virus is a strain of Influenza A or Influenza B or combinations thereof. In some embodiments, the strain of Influenza A or Influenza B is associated with birds, pigs, horses, dogs, humans or non-human primates. In the invention, the antigenic polypeptide encodes a hemagglutinin protein or fragment thereof. In some embodiments, the hemagglutinin protein is H1, H2, H3, H4, H5, H6, H7, H8, H9, H10, H11, H12, H13, H14, H15, H16, H17, H18, or a fragment thereof. In some embodiments, the hemagglutinin protein does not comprise a head domain (HA1). In some embodiments, the hemagglutinin protein comprises a portion of the head domain (HA1). In some embodiments, the hemagglutinin protein does not comprise a cytoplasmic domain. In some embodiments, the hemagglutinin protein comprises a portion of the cytoplasmic domain. In some embodiments, the truncated hemagglutinin protein. In some embodiments, the truncated hemagglutinin protein comprises a portion of the transmembrane domain. In some embodiments, the amino acid sequence of the hemagglutinin protein or fragment thereof comprises at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97% 98%, or 99% identify with any of the amino acid sequences provided in Table 6-14. In some embodiments, the virus is selected from the group consisting of H1N1, H3N2, H7N9, and H10N8. In some embodiments, the antigenic polypeptide is selected from those proteins listed in Tables 6-14, or fragments thereof.

[0017] In some embodiments, the NAV is multivalent. In some embodiments, the open reading frame of the one or more RNA polynucleotides encode at least 2, 3, 4, 5, 6, 7, 8, 9 or 10 antigenic polypeptides. In some embodiments, the open reading frame of the one or more RNA polynucleotides encode at least 10, 15, 20 or 50 antigenic polypeptides. In some embodiments, the open reading frame of the one or more RNA polynucleotides encode 2-10, 10-15, 15-20, 20-50, 50-100 or 100-200 antigenic polypeptides.

[0018] In some embodiments, the chemical modification is selected from the group consisting of pseudouridine, N1-methylpseudouridine, 2-thiouridine, 4'-thiouridine, 5-methylcytosine, 2-thio-1-methyl-1-deaza-pseudouridine, 2-thio-1-methyl-pseudouridine, 2-thio-5-aza-uridine , 2-thio-dihydropseudouridine, 2-thio-dihydrouridine, 2-thio-pseudouridine, 4-methoxy-2-thio-pseudouridine, 4-methoxy-pseudouridine, 4-thio-1-methyl-pseudouridine, 4-thio-pseudouridine, 5-aza-uridine, Dihydropseudouridine, 5-methoxyuridine and 2'-O-methyl uridine.. In some embodiments, the RNA polynucleotide includes a second chemical modification wherein said second chemical modification is selected from any of those listed in Tables 22 and 23.

[0019] In some embodiments, the RNA polynucleotide comprises SEQ ID NOs 2459-2621. In some embodiments, the RNA polynucleotide comprises a polynucleotide having at least 80% sequence identity to SEQ ID NOs 2459-2621. In some embodiments, the RNA polynucleotide comprises a polynucleotide encoding an amino acid sequence having at least 90% sequence identity to SEQ ID NO 2254. In some embodiments, the RNA polynucleotide comprises a polynucleotide encoding the amino acid sequence of SEQ ID NO 2254. In some embodiments, the RNA polynucleotide comprises a polynucleotide encoding an amino acid sequence having at least 90% sequence identity to SEQ ID NO 2259. In some embodiments, the RNA polynucleotide comprises a polynucleotide encoding the amino acid sequence of SEQ ID NO 2259. In some embodiments, the RNA polynucleotide comprises a polynucleotide encoding an amino acid sequence having at least 90% sequence identity to SEQ ID NO 2192. In some embodiments, the RNA polynucleotide comprises a polynucleotide encoding the amino acid sequence of SEQ ID NO 2192. In some embodiments, the RNA polynucleotide comprises a polynucleotide encoding an amino acid sequence having at least 90% sequence identity to SEQ ID NO 2200. In some embodiments, the RNA polynucleotide comprises a polynucleotide encoding the amino acid sequence of SEQ ID NO 2200. In some embodiments, the RNA polynucleotide comprises SEQ ID NO 2046. In some embodiments, the RNA polynucleotide comprises a polynucleotide having 80-98% sequence identity to SEQ ID NO 2046. In some embodiments, the RNA polynucleotide comprises SEQ ID NO 2119. In some embodiments, the RNA polynucleotide comprises a polynucleotide having 80-98% sequence identity to SEQ ID NO 2119. In some embodiments, the RNA polynucleotide comprises SEQ ID NO 2054. In some embodiments, the RNA polynucleotide comprises a polynucleotide having 80-98% sequence identity to SEQ ID NO 2054. In some embodiments, the RNA polynucleotide comprises SEQ ID NO 2127. In some embodiments, the RNA polynucleotide comprises a polynucleotide having 80-98% sequence identity to SEQ ID NO 2127. invention also provides the vaccine of the invention for use in a method of inducing an antigen specific immune response in a subject comprising administering the vaccines of the invention to the subject in an effective amount to produce an antigen specific immune response.

[0020] In some embodiments, the antigen specific immune response comprises a T cell response. In some embodiments, the antigen specific immune response comprises a B cell response. In some embodiments, the method of producing an antigen specific immune response involves a single administration of the vaccine. In some embodiments, the method further comprises administering a booster dose of the vaccine. In some embodiments, the vaccine is administered to the subject by intradermal or intramuscular injection.

[0021] In some embodiments, the booster dose of the vaccine is administered to the subject on day twenty one. In some embodiments, a dosage of between 10 ug / kg and 400 ug / kg of the vaccine is administered to the subject. In some embodiments, a dosage of 25 micrograms of the RNA polynucleotide is included in the vaccine administered to the subject. In some embodiments, a dosage of 100 micrograms of the RNA polynucleotide is included in the vaccine administered to the subject. In some embodiments, a dosage of 400 micrograms of the RNA polynucleotide is included in the vaccine administered to the subject. In some embodiments, the RNA polynucleotide accumulates at a 100 fold higher level in the local lymph node in comparison with the distal lymph node. The invention also provides the vaccine of the invention for use in a method of preventing or treating influenza viral infection comprising administering to a subject the vaccines of the invention.In some embodiments, the antigen specific immune response comprises a T cell response. In some embodiments, the antigen specific immune response comprises a B cell response. In some embodiments, the method of producing an antigen specific immune response involves a single administration of the vaccine. In some embodiments, the vaccine is administered to the subject by intradermal or intramuscular injection.

[0022] In the inventionthe NAV polynucleotides encode one or more polypeptides of an influenza strain as an antigen. Such antigens include, but are not limited to those antigens encoded by the polynucleotides listed in the Tables presented herein. In the table, the GenBank Accession Number or GI Accession Number represents either the complete or partial CDS of the encoded antigen. The NAV polynucleotides may comprise a region of any of the sequences listed in the tables or entire coding region of the mRNA listed. They may comprise hybrid or chimeric regions, or mimics or variants.

[0023] The details of various embodiments of the invention are set forth in the description below. Other features, objects, and advantages of the invention will be apparent from the description and the drawings, and from the claims.BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The foregoing and other objects, features and advantages will be apparent from the following description of particular embodiments of the invention, as illustrated in the accompanying drawings in which like reference characters refer to the same parts throughout the different views. The drawings are not necessarily to scale, emphasis instead being placed upon illustrating the principles of various embodiments of the invention. FIG. 1 is a schematic of a polynucleotide construct. FIG. 1A is a schematic of a polynucleotide construct taught in commonly owned co-pending US Patent Application 13 / 791,922 filed March 9, 2013. FIG. 1B is a schematic of a linear polynucleotide construct. FIG. 2 is a schematic of a series of chimeric polynucleotides of the present invention. FIG. 3 is a schematic of a series of chimeric polynucleotides illustrating various patterns of positional modifications and showing regions analogous to those regions of an mRNA polynucleotide. FIG. 4 is a schematic of a series of chimeric polynucleotides illustrating various patterns of positional modifications based on Formula I. FIG. 5 is a is a schematic of a series of chimeric polynucleotides illustrating various patterns of positional modifications based on Formula I and further illustrating a blocked or structured 3' terminus. FIGs. 6A and 6B are schematics of circular constructs of the present invention. FIGs. 7A-7B are schematics of circular constructs of the present invention. FIGs. 8A-8B are schematics of a circular constructs of the present invention. FIG 8A shows a circular construct comprising at least one sensor region and a spacer region. FIG. 8B shows a non-coding circular construct. FIG. 9 is a schematic of a non-coding circular construct of the present invention. FIG. 10 shows HA neutralization titres of a chemically modified mRNA influenza vaccine in comparison with protein and unmodified mRNA vaccines. FIG. 11 shows hemagglutinin inhibition titers in mice following vaccination with different doses and formulations of mRNA encoding the hemagglutinin protein of the H1N1 virus. FIG. 12A-AD shows percent survival of mice after vaccination and challenge with influenza A / PR / 8 / 34 virus. FIG. 12A shows percent survival at 1 week post challenge. FIG. 12B shows percent survival at 2 weeks post challenge. FIG. 12C shows percent survival at 3 weeks post challenge. FIG. 12D shows percent survival at 4 weeks post challenge. FIG. 13 shows the mean hemaglutination inhibition titers of mice after vaccination and challenge with influenza A / PR / 8 / 34 virus FIGs. 14A-14C shows CD4 T cell IFNγ cytokine responses. FIG. 14A shows IFNγ production upon H1 protein / peptide stimulation. FIG. 14B shows IFNγ production upon H7 protein / peptide stimulation. FIG. 14C shows IFNγ production upon PMA+ionomycin stimulation. FIGs. 15A-15D shows IgG production following H1 and H7 protein / peptide stimulation. FIG. 16 is a graph showing hemagglutinin inhibition titers (HAI) against H10 following administration of the H10N8 / N1-methyl pseudouridine / C0 formulation MC3 vaccine at the indicated dosages. FIG. 17 is a graph showing hemagglutinin inhibition titers (HAI) against H10 following administration of the H10N8 / N1-methyl pseudouridine / C1 formulation MC3 vaccine at the indicated dosages. FIG. 18 is a graph comparing hemagglutinin inhibition titers (HAI) against H7 following administration of 10 µg / dose of the H7N9 / C0 formulation compared to the H7N9 / C1 formulation. FIG. 19 is a graph of the mean hemagglutinin inhibition titers (HAI) in serum samples from cynomolgus monkey at various time points prior to and after administration of the indicated formulations and dosages. FIG. 20 is a graph showing the H7N9 viral load in ferrets challenged at day 21 after receiving a single immunization. FIGs. 21A-21D present mouse survival and HAI titers in mice challenged with a lethal dose following administration of a single dose of mRNA NAV encoding H7N9. FIG. 21A shows survival at day 7 post challenge. FIG. 21B shows survival at day 21 post challenge. FIG. 21C shows survival at day 84 post challenge. FIG. 21D shows HAI titers. FIG. 22 shows an alignment of amino acid sequences of hemagglutinin proteins from influenza A H7N9 strains relative to a consensus sequence. FIG. 23 shows an alignment of amino acid sequences of hemagglutinin proteins from influenza A H10N8 strains relative to a consensus sequence. DETAILED DESCRIPTION

[0025] It is of great interest in the fields of therapeutics, diagnostics, reagents and for biological assays to be able design, synthesize and deliver a nucleic acid, e.g., a ribonucleic acid (RNA) for example, a messenger RNA (mRNA) encoding a peptide or polypeptide of interest inside a cell, whether in vitro, in vivo, in situ or ex vivo, such as to effect physiologic outcomes which are beneficial to the cell, tissue or organ and ultimately to an organism. One beneficial outcome is to cause intracellular translation of the nucleic acid and production of at least one encoded peptide or polypeptide of interest.

[0026] Of particular interest, is the ability to design, synthesize and deliver a nucleic acid, e.g., a ribonucleic acid (RNA), for example, a messenger RNA (mRNA), which encodes an antigen, e.g., an antigen derived from an infectious microorganism, for the purpose of vaccination.

[0027] The present invention is set out in the appended claims.

[0028] According to the present invention, the polynucleotides are modified in a manner as to avoid the deficiencies of or provide improvements over other polynucleotide molecules of the art.

[0029] Although attempts have been made to produce functional RNA vaccines, including mRNA vaccines and self-replicating RNA vaccines, the therapeutic efficacy of these RNA vaccines have not yet been fully established. Quite surprisingly, the inventors have discovered a class of formulations for delivering mRNA vaccines in vivo that results in significantly enhanced, and in many respects synergistic, immune responses including enhanced antigen generation and functional antibody production with neutralization capability. These results are achieved even when significantly lower doses of the mRNA are administered in comparison with mRNA doses used in other classes of lipid based formulations. The formulations of the invention have demonstrated significant unexpected in vivo immune responses sufficient to establish the efficacy of functional mRNA vaccines as prophylactic and therapeutic agents.

[0030] The invention involves, in some aspects, the surprising finding that lipid nanoparticle (LNP) formulations significantly enhance the effectiveness of mRNA vaccines, including chemically modified mRNA vaccines. The efficacy of mRNA vaccines formulated in LNP was examined in vivo using several distinct viral antigens and in a variety of different animal models. The results presented herein demonstrate the unexpected superior efficacy of the mRNA vaccines formulated in LNP over other mRNA vaccines formulated in other lipid based carriers as well as over protein antigens.

[0031] In addition to providing an enhanced immune response, the formulations of the invention generate a more rapid immune response following a single dose of antigen than other mRNA or protein based vaccines tested. A study described herein involved intravenous (IV), intramuscular (IM), or intradermal (ID) vaccination of mice, followed by challenge with a lethal dose of virus. In addition to all of the vaccinated animals surviving the lethal dose, significantly stronger early immune responses were observed (anti-viral activity via virus neutralization assay and HA inhibition (HAI)) in comparison to protein antigen and other lipid based formulations (lipoplex). The data demonstrates that as early as 1 week after vaccination two groups of animals receiving a mRNA-LNP formulation (ID or IM) displayed HAI titers over 40, at 60 and 114, respectively. An HAI titer of greater than 40 is deemed sufficient to protect from a lethal challenge of influenza. The rapid response was unexpected, particularly when compared to the response seen with protein antigen and mRNA vaccines formulated in other lipid carriers (lipoplex), which at one week and even at three weeks following vaccination continued to show ineffective HAI titers of less than 40.

[0032] At each of the later time points (3 weeks and 5 weeks), the formulations of the invention continued to provide significantly stronger therapeutic responses than did protein antigen. In fact both chemically unmodified and modified mRNA-LNP formulation administered by IV route had enhanced HAI titers with respect to the protein antigen. By week 3, all of the animals receiving an mRNA-LNP formulation by IM or ID administration displayed HAI activity over 40, as compared to protein antigen, which at one week and three weeks continued to show HAI titers of less than 40. By week 5 a mRNA-LNP formulation administered by ID route had a surprising HAI activity of greater than 10,000, in contrast to the HAI titer of around 400 for protein antigen at that time point. Mice receiving a mRNA-LNP formulation also displayed neutralizing activity of 79-250 (IM) and 250 (ID) by microneutralization assay, in comparison to protein antigen, which had undetectable neutralization activity at that time point. By week 5 following vaccination, five of the six LNP formulated groups showed high neutralizing activity between 789 and 24892. In contrast, the mice vaccinated with protein antigen displayed neutralizing activity in only 3 of 5 mice and ranging only between 79 and 250.

[0033] The mRNA-LNP formulations of the invention also produced quantitatively and qualitatively better immune responses than did mRNA vaccines formulated in a different lipid carrier (lipoplex). At week 5 the mRNA -lipoplex vaccine produced HAI titers of 197, in comparison to those achieved by the mRNA-LNP formulations of the invention (HAI titers of 635-10,152). At all other time points and for all of the mRNA-lipoplex vaccines, none of the HAI titers reached the critical level of greater than 40. Additionally, the mRNA -lipoplex vaccines did not result in any detectable neutralizing activity in the microneutralization activity, even as late as five weeks after vaccination.

[0034] The data described herein demonstrate that the formulations of the invention produced significant unexpected improvements over both existing protein antigen vaccines and mRNA vaccine formulations, including: 100% rescue from lethal influenza challenge with rapid onset of protective antibody titers after 1 week and high antibody titers, i.e., 50 fold over unmodified mRNA and 20 fold over the protein vaccine.

[0035] Additionally, the mRNA-LNP formulations of the invention were superior to other lipid formulations even when the dose of mRNA was significantly lower than in the other lipid formulations. For instance, the data described above was generated using 10 µg of mRNA in the mRNA-LNP formulations in contrast to 80 µg of mRNA in the mRNA-lipoplex formulation.

[0036] The formulations of the invention also showed strong efficacy in several non-rodent animal models, including non-human primates. Highly effective vaccination was observed in cynomoglus monkeys and ferrets. Cynomoglus monkeys were vaccinated with various doses of mRNA-LNP formulations (50 µg / dose, 200 µg / dose, 400 µg / dose). Quite surprisingly, the vaccine formulations of the invention at all doses measured significantly reduced viral titers in the lungs of ferrets when exposed to virus just 7 days following single vaccination. Statistically significant increases in antibody titer as measured by HAI and microneutralization were detected as early as 7 days following vaccination and through the entire length of the study (84 days). A single vaccination was able to eliminate all virus in most animals.

[0037] The LNP used in the studies described herein has been used previously to deliver siRNA various in animal models as well as in humans. In view of the observations made in association with the siRNA delivery of LNP formulations, the fact that LNP is useful in vaccines is quite surprising. It has been observed that therapeutic delivery of siRNA formulated in LNP causes an undesirable inflammatory response associated with a transient IgM response, typically leading to a reduction in antigen production and a compromised immune response. In contrast to the findings observed with siRNA, the LNP-mRNA formulations of the invention are demonstrated herein to generate enhanced IgG levels, sufficient for prophylactic and therapeutic methods rather than transient IgM responses.I. Nucleic Acid Vaccines (NAVs)

[0038] Nucleic Acid Vaccines (NAVs) of the present disclosure comprise one or more polynucleotides, e.g., polynucleotide constructs, which encode one or more wild type or engineered antigens. Exemplary polynucleotides, e.g., polynucleotide constructs, include antigen-encoding RNA polynucleotides, e.g., mRNAs. In the disclosure, polynucleotides of the disclosure e.g., antigen-encoding RNA polynucleotides, may include at least one chemical modification. References herein to "NAVs of the invention" relate to those as set out in the appended claims.

[0039] NAV compositions of the invention may comprise other components including, but not limited to, tolerizing agents or adjuvants.Tolerizing agent or composition

[0040] Where auto-immunity mediated side effects occur, tolerizing mRNA and / or such as any of those taught for example in USSN 61 / 892,556 filed October 18, 2013, and PCT / US2014 / 61104 filed October 17, 2014) are co-administered with the NAV to induce antigen specific tolerance.Adjuvants

[0041] Adjuvants or immune potentiators, may also be administered with or in combination with one or more NAVs.

[0042] In one embodiment, an adjuvant acts as a co-signal to prime T-cells and / or B-cells and / or NK cells as to the existence of an infection.

[0043] Advantages of adjuvants include the enhancement of the immunogenicity of antigens, modification of the nature of the immune response, the reduction of the antigen amount needed for a successful immunization, the reduction of the frequency of booster immunizations needed and an improved immune response in elderly and immunocompromised vaccinees. These may be co-administered by any route, e.g., intramusculary, subcutaneous, IV or intradermal injections.

[0044] Adjuvants useful in the present invention may include, but are not limited to, natural or synthetic. They may be organic or inorganic.

[0045] Aduvants may be selected from any of the classes (1) mineral salts, e.g., aluminium hydroxide and aluminium or calcium phosphate gels; (2) emulsions including: oil emulsions and surfactant based formulations, e.g., microfluidised detergent stabilised oil-in-water emulsion, purified saponin, oil-in-water emulsion, stabilised water-in-oil emulsion; (3) particulate adjuvants, e.g., virosomes (unilamellar liposomal vehicles incorporating influenza haemagglutinin), structured complex of saponins and lipids, polylactide co-glycolide (PLG); (4) microbial derivatives; (5) endogenous human immunomodulators; and / or (6) inert vehicles, such as gold particles; (7) microorganism derived adjuvants; (8) tensoactive compunds; (9) carbohydrates; or combinations thereof.

[0046] Adjuvants for DNA nucleic acid vaccines (DNA) have been disclosed in, for example, Kobiyama, et al Vaccines, 2013, 1(3), 278-292. Any of the adjuvants disclosed by Kobiyama may be used in the RNAVs of the present invention.

[0047] Other adjuvants which may be utilized in the RNAVs of the present invention include any of those listed on the web-based vaccine adjuvant database, Vaxjo; http: / / www.violinet.org / vaxjo / and described in for example Sayers, et al., J. Biomedicine and Biotechnology, volume 2012 (2012), Article ID 831486, 13 pages

[0048] Selection of appropriate adjuvants will be evident to one of ordinary skill in the art. Specific adjuvants may include,without limitation, cationic liposome-DNA complex JVRS-100, aluminum hydroxide vaccine adjuvant, aluminum phosphate vaccine adjuvant, aluminum potassium sulfate adjuvant, alhydrogel, ISCOM(s) ™< , Freund's Complete Adjuvant, Freund's Incomplete Adjuvant, CpG DNA Vaccine Adjuvant, Cholera toxin, Cholera toxin B subunit, Liposomes, Saponin Vaccine Adjuvant, DDA Adjuvant, Squalene-based Adjuvants, Etx B subunit Adjuvant, IL-12 Vaccine Adjuvant, LTK63 Vaccine Mutant Adjuvant, TiterMax Gold Adjuvant, Ribi Vaccine Adjuvant, Montanide ISA 720 Adjuvant, Corynebacterium-derived P40 Vaccine Adjuvant, MPL ™< Adjuvant, AS04, AS02, Lipopolysaccharide Vaccine Adjuvant, Muramyl Dipeptide Adjuvant, CRL1005, Killed Corynebacterium parvum Vaccine Adjuvant, Montanide ISA 51, Bordetella pertussis component Vaccine Adjuvant, Cationic Liposomal Vaccine Adjuvant, Adamantylamide Dipeptide Vaccine Adjuvant, Arlacel A, VSA-3 Adjuvant, Aluminum vaccine adjuvant, Polygen Vaccine Adjuvant, Adjumer ™< , Algal Glucan, Bay R1005, Theramide ®< , Stearyl Tyrosine, Specol, Algammulin, Avridine ®< , Calcium Phosphate Gel, CTA1-DD gene fusion protein, DOC / Alum Complex, Gamma Inulin, Gerbu Adjuvant, GM-CSF, GMDP, Recombinant hIFN-gamma / Interferon-g, Interleukin-1β, Interleukin-2, Interleukin-7, Sclavo peptide, Rehydragel LV, Rehydragel HPA, Loxoribine, MF59, MTP-PE Liposomes, Murametide, Murapalmitine, D-Murapalmitine, NAGO, NonIonic Surfactant Vesicles, PMMA, Protein Cochleates, QS-21, SPT (Antigen Formulation), nanoemulsion vaccine adjuvant, AS03, Quil-A vaccine adjuvant, RC529 vaccine adjuvant, LTR192G Vaccine Adjuvant, E. coli heat-labile toxin, LT, amorphous aluminum hydroxyphosphate sulfate adjuvant, Calcium phosphate vaccine adjuvant, Montanide Incomplete Seppic Adjuvant, Imiquimod, Resiquimod, AF03, Flagellin, Poly(I:C), ISCOMATRIX ®< , Abisco-100 vaccine adjuvant, Albumin-heparin microparticles vaccine adjuvant, AS-2 vaccine adjuvant, B7-2 vaccine adjuvant, DHEA vaccine adjuvant, Immunoliposomes Containing Antibodies to Costimulatory Molecules, SAF-1, Sendai Proteoliposomes, Sendai-containing Lipid Matrices, Threonyl muramyl dipeptide (TMDP), Ty Particles vaccine adjuvant, Bupivacaine vaccine adjuvant, DL-PGL (Polyester poly (DL-lactide-co-glycolide)) vaccine adjuvant, IL-15 vaccine adjuvant, LTK72 vaccine adjuvant, MPL-SE vaccine adjuvant, non-toxic mutant E112K of Cholera Toxin mCT-E112K, and / or Matrix-S.

[0049] Other adjuvants which may be co-administered with the NAVs of the invention include, but are not limited to interferons, TNF-alpha, TNF-beta, chemokines such as CCL21, eotaxin, HMGB1, SA100-8alpha, GCSF, GMCSF, granulysin, lactoferrin, ovalbumin, CD-40L, CD28 agonists, PD-1, soluble PD1, L1 or L2, or interleukins such as IL-1, IL-2, IL-4, IL-6, IL-7, IL-10, IL-12, IL-13, IL-21, IL-23, IL-15, IL-17, and IL-18. These may be administered with the NAV on the same encoded polynucleotide, e.g., polycistronic, or as separate mRNA encoding the adjuvant and antigen.Valency

[0050] NAVs of the present invention may vary in their valency. Valency refers to the number of antigenic components in the NAV or NAV polynucleotide (e.g., RNA polynucleotide) or polypeptide. In some embodiments, the NAVs are monovalent. In some embodiments, the NAVs are divalent. In some embodments the NAVs are trivalent. In some embodiments the NAVs are multi-valent. Multivalent vaccines may comprise 2, 3, 4, 5, 6, 7, 8, 9, 10, 11,12,13,14, 15, 16, 17, 18, 19, 20, or more antigens or antigenic moieties (e.g., antigenic peptides, etc.). The antigenic components of the NAVs may be on a single polynucleotide or on separate polynucleotides.Therapeutics

[0051] The NAVs of the present invention can be used as therapeutic or prophylactic agents. They are provided for use in medicine and / or for the priming of immune effector cells, e.g., stimulate / transfect PBMCs ex vivo and re-infuse the activated cells. For example, a NAV described herein can be administered to a subject, wherein the polynucleotides is translated in vivo to produce an antigen. Provided are compositions, methods, kits, and reagents for diagnosis, treatment or prevention of a disease or condition in humans and other mammals. The active therapeutic agents of the disclosure include NAVs, cells containing NAVs or polypeptides translated from the polynucleotides contained in said NAVs.

[0052] Provided herein are methods of inducing translation of a polypeptide (e.g., antigen or immunogen) in a cell, tissue or organism using the polynucleotides of the NAVs described herein. Such translation can be in vivo, ex vivo, in culture, or in vitro. The cell, tissue or organism is contacted with an effective amount of a composition containing a NAV which contains a polynucletotide that has at least one a translatable region encoding the polypeptide of intereste (e.g., antigen or immunogen).

[0053] An "effective amount" of the NAV composition is provided based, at least in part, on the target tissue, target cell type, means of administration, physical characteristics of the polynucleotide (e.g., size, and extent of modified nucleosides) and other components of the NAV, and other determinants. In general, an effective amount of the NAV composition provides an induced or boosted immune response as a function of antigen production in the cell, preferably more efficient than a composition containing a corresponding unmodified polynucleotide encoding the same antigen. Increased antigen production may be demonstrated by increased cell transfection (i.e., the percentage of cells transfected with the NAV), increased protein translation from the polynucleotide, decreased nucleic acid degradation (as demonstrated, e.g., by increased duration of protein translation from a modified polynucleotide), or altered innate immune response of the host cell.

[0054] Aspects of the disclosure are directed to methods of inducing in vivo translation of a polypeptide antigen in a mammalian subject in need thereof. Therein, an effective amount of a NAV composition containing a polynucleotide that has at least one structural or chemical modification and a translatable region encoding the polypeptide (e.g., antigen or immunogen) is administered to the subject using the delivery methods described herein. The polynucleotide is provided in an amount and under other conditions such that the polynucleotide is translated in the cell. The cell in which the polynucleotide is localized, or the tissue in which the cell is present, may be targeted with one or more than one rounds of NAV administration.

[0055] In certain instances, the administered NAVs comprising polynucleotides directs production of one or more polypeptides that provide a functional immune system-related activity which is substantially absent in the cell, tissue or organism in which the polypeptide is translated. For example, the missing functional activity may be enzymatic, structural, or gene regulatory in nature. In related instances, the administered polynucleotides directs production of one or more polypeptides that increases (e.g., synergistically) a functional activity related to the immune system which is present but substantially deficient in the cell in which the polypeptide is translated.

[0056] Additionally, the polypeptide antagonizes, directly or indirectly, the activity of a biological moiety present in, on the surface of, or secreted from the cell. Examples of antagonized biological moieties include lipids (e.g., cholesterol), a lipoprotein (e.g., low density lipoprotein), a nucleic acid, a carbohydrate, a protein toxin such as shiga and tetanus toxins, or a small molecule toxin such as botulinum, cholera, and diphtheria toxins. Additionally, the antagonized biological molecule may be an endogenous protein that exhibits an undesirable activity, such as a cytotoxic or cytostatic activity.

[0057] The proteins described herein may be engineered for localization within the cell, potentially within a specific compartment such as the cytoplasms or nucleus, or are engineered for secretion from the cell or translocation to the plasma membrane of the cell.

[0058] In some instances, polynucleotides of the NAVs and their encoded polypeptides in accordance with the present disclosure may be used for treatment of any of a variety of diseases, disorders, and / or conditions, including but not limited to viral infections (e.g., influenza, HIV, HCV, RSV), parasitic infentions or bacterial infections.

[0059] The subject to whom the therapeutic agent may be administered suffers from or may be at risk of developing a disease, disorder, or deleterious condition. Provided are methods of identifying, diagnosing, and classifying subjects on these bases, which may include clinical diagnosis, biomarker levels, genome-wide association studies (GWAS), and other methods known in the art.

[0060] The agents can be administered simultaneously, for example in a combined unit dose (e.g., providing simultaneous delivery of both agents). The agents can also be administered at a specified time interval, such as, but not limited to, an interval of minutes, hours, days or weeks. Generally, the agents may be concurrently bioavailable, e.g., detectable, in the subject. In some instances, the agents may be administered essentially simultaneously, for example two unit dosages administered at the same time, or a combined unit dosage of the two agents. In other instances, the agents may be delivered in separate unit dosages. The agents may be administered in any order, or as one or more preparations that includes two or more agents. In a preferred instance, at least one administration of one of the agents, e.g., the first agent, may be made within minutes, one, two, three, or four hours, or even within one or two days of the other agent, e.g., the second agent. In some instances, combinations can achieve synergistic results, e.g., greater than additive results, e.g., at least 25, 50, 75, 100, 200, 300, 400, or 500% greater than additive results.Modulation of the Immune ResponseActivation of the immune response

[0061] According to the present disclosure, the NAVs comprising the polynucleotides disclosed herein, e.g., comprising RNA polynucleotides, may act as a single composition as a vaccine. As used herein, a "vaccine" refers to a composition, for example, a substance or preparation that stimulates, induces, causes or improves immunity in an organism, e.g., an animal organism, for example, a mammalian organism (e.g., a human.) Preferably, a vaccine provides immunity against one or more diseases or disorders in the organism, including prophylactic and / or therapeutic immunity. Exemplary vaccines includes one or more agents that resembles an infectious agent, e.g., a disease-causing microorganism, and can be made, for example, from live, attenuated, modified, weakened or killed forms of disease-causing microorganisms, or antigens derived therefrom, including combinations of antigenic components. In exemplary instances, a vaccine stimulates, induces causes or improves immunity in an organism or causes or mimics infection in the organism without inducing any disease or disorder. A vaccine introduces an antigen into the tissues, extracellular space or cells of a subject and elicits an immune response, thereby protecting the subject from a particular disease or pathogen infection. The polynucleotides of the present disclosure may encode an antigen and when the polynucleotides are expressed in cells, a desired immune reponse is achieved.

[0062] NAVs may be administered prophylactically or therapeutically as part of an active immunization scheme to healthy individuals or early in infection during the incubation phase or during active infection after onset of symptoms.

[0063] The NAVs of the present disclosure may also be administered as a second line treatment after the standard first line treatments such as antibiotics and antivirals have failed to induce passive immunity. In this regard, the NAVs of the present disclosure are useful in settings where resistance to first line treatments has developed and disease persists and induces chronic disease.

[0064] The use of RNA in or as a vaccine overcomes the disadvantages of conventional genetic vaccination involving incorporating DNA into cells in terms of safeness, feasibility, applicability, and effectiveness to generate immune responses. RNA molecules are considered to be significantly safer than DNA vaccines, as RNAs are more easily degraded. They are cleared quickly out of the organism and cannot integrate into the genome and influence the cell's gene expression in an uncontrollable manner. It is also less likely for RNA vaccines to cause severe side effects like the generation of autoimmune disease or anti-DNA antibodies (Bringmann A. et al., Journal of Biomedicine and Biotechnology (2010), vol. 2010, article ID623687). Transfetion with RNA requires only insertion into the cell's cytoplasm, which is easier to achieve than into the nucleus. Howerver, RNA is susceptible to RNase degradation and other natural decomposition in the cytoplasm of cells.

[0065] Various attempts to increase the stability and shelf life of RNA vaccines. US 2005 / 0032730 to Von Der Mulbe et al. discloses improving the stability of mRNA vaccine compositions by increasing G(guanosine) / C(cytosine) content of the mRNA molecules. US 5580859 to Felgner et al. teaches incorporating polynucleotide sequences coding for regulatory proteins that binds to and regulates the stabilities of mRNA. While not wishing to be bound by theory, it is believed that the polynucleotides vaccines (NAVs) of the invention will result in improved stability and therapeutic efficacy due at least in part to the specificity, purity and selectivity of the construct designs.

[0066] Additionally, certain modified nucleosides, or combinations thereof, when introduced into the polynucleotides of the NAVs of the invention will activate the innate immune response. Such activating molecules are useful as adjuvants when combined with polypeptides and / or other vaccines. In certain instances, the activating molecules contain a translatable region which encodes for a polypeptide sequence useful as a vaccine, thus providing the ability to be a self-adjuvant.

[0067] In one instance, the polynucleotides of the NAVs of the present disclosure may be used in the prevention, treatment and diagnosis of diseases and physical disturbances caused by infectious agents. The polynucleotide of the present disclosure may encode at least one polypeptide of interest (antigen) and may be provided to an individual in order to stimulate the immune system to protect against the disease-causing agents. As a non-limiting example, the biological activity and / or effect from an antigen or infectious agent may be inhibited and / or abolished by providing one or more polynucleotides which have the ability to bind and neutralize the antigen and / or infectious agent.

[0068] As a non-limiting example, the polynucleotides encoding an immunogen may be delivered to cells to trigger multiple innate response pathways (see International Pub. No. WO2012006377 and US Patent Publication No. US20130177639 ). As another non-limiting example, the polynucleotides of the NAVs of the present disclosure encoding an immunogen may be delivered to a vertebrate in a dose amount large enough to be immunogenic to the vertebrate (see International Pub. No. WO2012006372 and WO2012006369 and US Publication No. US20130149375 and US20130177640

[0069] NAVs of the present invention may be utilized in various settings depending on the prevalence of the infection or the degree or level of unmet medical need. The NAVs of the present invention may be utilized to treat and / or prevent influenza infection, i.e. diseases and conditions related to influenza virus infection (seasonal and pandemic).

[0070] Symptoms of the influenza infection include dry cough, fever, chills, myalgias progressing to respiratory failure and the risk of secondary bacterial infections (e.g., MRSA). Seasonal influenza is ubiquitous and consists of three principal strains (A [H1N1], A [H3N2], and B), which are covered by the annual vaccine. Pandemic flu occurs because the viruses' unique reassortment ability allowing antigenic shift as well as transfer between avian and swine flu strains. One emerging concern in Southeast Asia is the pandemic potential of several new strains. Such pandemic outbreaks have a high mortality rate with few available treatments. Anti-virals only provide symptomatic relief and must be given in the first 48 hours.

[0071] The NAVs of the present invention have superior properties in that they produce much larger antibody titers, produce responses early than commercially available anti-virals and may be administered after the critical 48 hour period while retaining efficacy.

[0072] While not wishing to be bound by theory, the inventors hypothesize that the NAVs of the invention, as mRNA polynucleotides, are better designed to produce the appropriate protein conformation on translation as the NAVs co-opt natural cellular machinery. Unlike traditional vaccines which are manufactured ex vivo and may trigger unwanted cellular responses, the NAVs are presented to the cellular system in a more native fashion. Adding to the superior effects may also involve the formulations utilized which may neither serve to shield nor traffic the NAVs.

[0073] According to the present invention, NAVs represent a tailored active vaccine that not only can prevent infection but can limit transmission of influenza.

[0074] NAVs may be used to prevent pandemic influenza by reacting to emerging new strains with the very rapid NAV-based vaccine production process. A New NAV for treating or prophylactically preventing influenza outbreaks, including for emerging strains (e.g., H10N8), may be produced in less than six weeks, from the time of antigen identification to available vaccine.

[0075] In some instances, a single injection of a single antigen encoding NAV polynucleotide may provide protection for an entire flu season.

[0076] The polynucleotides of the NAVs of the invention are not self-replicating RNA. Self-replicating RNA have been described, for instance in US Pub. No. US20110300205 and International Pub. No. WO2011005799 and WO2013055905.

[0077] In one instance, the polynucleotides of the NAVs of the invention may encode amphipathic and / or immunogenic amphipathic peptides.

[0078] In on embodiment, a formulation of the polynucleotides of the NAVs of the invention may further comprise an amphipathic and / or immunogenic amphipathic peptide. As a non-limiting example, the polynucleotides comprising an amphipathic and / or immunogenic amphipathic peptide may be formulated as described in US. Pub. No. US20110250237 and International Pub. Nos. WO2010009277 and WO2010009065.

[0079] In one embodiment, the polynucleotides of the NAVs of the invention may be immunostimultory. As a non-limiting example, the polynucleotides may encode all or a part of a positive-sense or a negative-sense stranded RNA virus genome (see International Pub No. WO2012092569 and US Pub No. US20120177701). In another non-limiting example, the immunostimultory polynucleotides of the present invention may be formulated with an excipient for administration as described herein and / or known in the art (see International Pub No. WO2012068295 and US Pub No. US20120213812). The polynucleotides may further comprise a sequence region encoding a cytokine that promotes the immune response, such as a monokine, lymphokine, interleukin or chemokine, such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12, INF-α, INF-γ, GM-CFS, LT-α, or growth factors such as hGH.

[0080] In one embodiment, the response of the vaccine formulated by the methods described herein may be enhanced by the addition of various compounds to induce the therapeutic effect. As a non-limiting example, the vaccine formulation may include a MHC II binding peptide or a peptide having a similar sequence to a MHC II binding peptide (see International Pub Nos. WO2012027365, WO2011031298 and US Pub No. US20120070493, US20110110965). As another example, the vaccine formulations may comprise modified nicotinic compounds which may generate an antibody response to nicotine residue in a subject (see International Pub No. WO2012061717 and US Pub No. US20120114677).

[0081] In one embodiment, the effective amount of the polynucleotides of the NAVs of the invention provided to a cell, a tissue or a subject may be enough for immune prophylaxis.

[0082] In one instance, the polynucleotides of the NAVs of the invention may be administrated with other prophylactic or therapeutic compounds. As a non-limiting example, the prophylactic or therapeutic compound may be an adjuvant or a booster. As used herein, when referring to a prophylactic composition, such as a vaccine, the term "booster" refers to an extra administration of the prophylactic composition. A booster (or booster vaccine) may be given after an earlier administration of the prophylactic composition. The time of administration between the intial administration of the prophylactic composition and the booster may be, but is not limited to, 1 minute, 2 minutes, 3 minutes, 4 minutes, 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9 minutes, 10 minutes, 15 minutes, 20 minutes 35 minutes, 40 minutes, 45 minutes, 50 minutes, 55 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 9 hours, 10 hours, 11 hours, 12 hours, 13 hours, 14 hours, 15 hours, 16 hours, 17 hours, 18 hours, 19 hours, 20 hours, 21 hours, 22 hours, 23 hours, 1 day, 36 hours, 2 days, 3 days, 4 days, 5 days, 6 days, 1 week, 10 days, 2 weeks, 3 weeks, 1 month, 2 months, 3 months, 4 months, 5 months, 6 months, 7 months, 8 months, 9 months, 10 months, 11 months, 1 year, 18 months, 2 years, 3 years, 4 years, 5 years, 6 years, 7 years, 8 years, 9 years, 10 years, 11 years, 12 years, 13 years, 14 years, 15 years, 16 years, 17 years, 18 years, 19 years, 20 years, 25 years, 30 years, 35 years, 40 years, 45 years, 50 years, 55 years, 60 years, 65 years, 70 years, 75 years, 80 years, 85 years, 90 years, 95 years or more than 99 years.

[0083] In one instance, the polynucleotides of the NAVs of the invention may be administered intranasally similar to the administration of live vaccines. In another aspect the polynucleotide may be administered intramuscularly or intradermally similarly to the administration of inactivated vaccines known in the art.

[0084] In one instance, the NAVs of the invention may be used to protect against and / or prevent the transmission of an emerging or engineered threat which may be known or unknown.

[0085] In another embodiment, the NAVs may be formulated by the methods described herein. In one aspect, the formulation may comprise a NAV or polynucleotide which can can have a therapetutic and / or prophylactic effect on more than one disease, disorder or condition.

[0086] In addition, the NAV antibodies of the present invention may be used for research in many applications, such as, but not limited to, identifying and locating intracellular and extracellular proteins, protein interaction, signal pathways and cell biology.

[0087] In another instance, the NAV may be used in to reduce the risk or inhibit the infection of influenza viruses such as, but not limited to, the highly pathogenic avian influenza virus (such as, but not limited to, H5N1 subtype) infection and human influenza virs (such as, but not limited to, H1N1 subtype and H3N2 subtype) infection. The polynucleotide described herein which may encode any of the protein sequences described in US Patent No. 8470771, may be used in the treatment or to reduce the risk of an influenza infection.

[0088] In one instance, the NAV may be used as a vaccine and may further comprise an adjuvant which may enable the vaccine to elicit a higher immune response. As a non-limiting example, the adjuvant could be a sub-micron oil-in-water emulsion which can elicit a higher immune response in human pediatric populations (see e.g., the adjuvanted vaccines described in US Patent Publication No. US20120027813 and US Patent No. US8506966).II. Infectious Agents and Antigens

[0089] NAVs of the present disclosure may be used to protect, treat or cure infection arising from contact with an infectious agent, In the invention, the infectious agent is a strain of Influenza A or Influenza B or combinations thereof and the antigenic polipeptide is a hemagglutinin protein or fragment thereof.A. Managing InfectionAntibiotic Combinations

[0090] In one instance, the NAVs of the present disclosure e.g., NAVs comprising one or more antigen-encoding polynucleotides of the present disclosure may be administered in conjunction with one or more antibiotics.Antibacterial agents

[0091] Anti-bacterial agents include, but are not limited to, aminoglycosides (e.g., amikacin (AMIKIN ®< ), gentamicin (GARAMYCIN ®< ), kanamycin (KANTREX ®< ), neomycin (MYCIFRADIN ®< ), netilmicin (NETROMYCIN ®< ), tobramycin (NEBCIN ®< ), Paromomycin (HUMATIN ®< )), ansamycins (e.g., geldanamycin, herbimycin), carbacephem (e.g., loracarbef (LORABID ®< ), Carbapenems (e.g., ertapenem (INVANZ ®< ), doripenem (DORIBAX ®< ), imipenem / cilastatin (PRIMAXIN ®< ), meropenem (MERREM ®< ), cephalosporins (first generation) (e.g., cefadroxil (DURICEF ®< ), cefazolin (ANCEF ®< ), cefalotin or cefalothin (KEFLIN ®< ), cefalexin (KEFLEX ®< ), cephalosporins (second generation) (e.g., cefaclor (CECLOR ®< ), cefamandole (MANDOL ®< ), cefoxitin (MEFOXIN ®< ), cefprozil (CEFZIL ®< ), cefuroxime (CEFTIN ®< , ZINNAT ®< )), cephalosporins (third generation) (e.g., cefixime (SUPRAX ®< ), cefdinir (OMNICEF ®< , CEFDIEL ®< ), cefditoren (SPECTRACEF ®< ), cefoperazone (CEFOBID ®< ), cefotaxime (CLAFORAN ®< ), cefpodoxime (VANTIN ®< ), ceftazidime (FORTAZ ®< ), ceftibuten (CEDAX ®< ), ceftizoxime (CEFIZOX ®< ), ceftriaxone (ROCEPHIN ®< )), cephalosporins (fourth generation) (e.g., cefepime (MAXIPIME ®< )), cephalosporins (fifth generation) (e.g., ceftobiprole (ZEFTERA ®< )), glycopeptides (e.g., teicoplanin (TARGOCID ®< ), vancomycin (VANCOCIN ®< ), telavancin (VIBATIV ®< )), lincosamides (e.g., clindamycin (CLEOCIN ®< ), lincomycin (LINCOCIN ®< )), lipopeptide (e.g., daptomycin (CUBICIN ®< )), macrolides (e.g., azithromycin (ZITHROMAX ®< , SUMAMED ®< , ZITROCIN ®< ), clarithromycin (BIAXIN ®< ), dirithromycin (DYNABAC ®< ), erythromycin (ERYTHOCIN ®< , ERYTHROPED ®< ), roxithromycin, troleandomycin (TAO ®< ), telithromycin (KETEK ®< ), spectinomycin (TROBICIN ®< )), monobactams (e.g., aztreonam (AZACTAM ®< )), nitrofurans (e.g., furazolidone (FUROXONE ®< ), nitrofurantoin (MACRODANTIN ®< , MACROBID ®< )), penicillins (e.g., amoxicillin (NOVAMOX ®< , AMOXIL ®< ), ampicillin (PRINCIPEN ®< ), azlocillin, carbenicillin (GEOCILLIN ®< ), cloxacillin (TEGOPEN ®< ), dicloxacillin (DYNAPEN ®< ), flucloxacillin (FLOXAPEN ®< ), mezlocillin (MEZLIN ®< ), methicillin (STAPHCILLIN ®< ), nafcillin (UNIPEN ®< ), oxacillin (PROSTAPHLIN ®< ), penicillin G (PENTIDS ®< ), penicillin V (PEN-VEE-K ®< ), piperacillin (PIPRACIL ®< ), temocillin (NEGABAN ®< ), ticarcillin (TICAR ®< )), penicillin combinations (e.g., amoxicillin / clavulanate (AUGMENTIN ®< ), ampicillin / sulbactam (UNASYN ®< ), piperacillin / tazobactam (ZOSYN ®< ), ticarcillin / clavulanate (TIMENTIN ®< )), polypeptides (e.g., bacitracin, colistin (COLY-MYCIN-S ®< ), polymyxin B, quinolones (e.g., ciprofloxacin (CIPRO ®< , CIPROXIN ®< , CIPROBAY ®< ), enoxacin (PENETREX ®< ), gatifloxacin (TEQUIN ®< ), levofloxacin (LEVAQUIN ®< ), lomefloxacin (MAXAQUIN ®< ), moxifloxacin (AVELOX ®< ), nalidixic acid (NEGGRAM ®< ), norfloxacin (NOROXIN ®< ), ofloxacin (FLOXIN ®< , OCUFLOX ®< ), trovafloxacin (TROVAN ®< ), grepafloxacin (RAXAR ®< ), sparfloxacin (ZAGAM ®< ), temafloxacin (OMNIFLOX ®< )), sulfonamides (e.g., mafenide (SULFAMYLON ®< ), sulfonamidochrysoidine (PRONTOSIL ®< ), sulfacetamide (SULAMYD ®< , BLEPH-10 ®< ), sulfadiazine (MICRO-SULFON ®< ), silver sulfadiazine (SILVADENE ®< ), sulfamethizole (THIOSULFIL FORTE ®< ), sulfamethoxazole (GANTANOL ®< ), sulfanilimide, sulfasalazine (AZULFIDINE ®< ), sulfisoxazole (GANTRISIN ®< ), trimethoprim (PROLOPRIM ®< ), TRIMPEX ®< ), trimethoprim-sulfamethoxazole (co-trimoxazole) (TMP-SMX) (BACTRIM ®< , SEPTRA ®< )), tetracyclines (e.g., demeclocycline (DECLOMYCIN ®< ), doxycycline (VIBRAMYCIN ®< ), minocycline (MINOCIN ®< ), oxytetracycline (TERRAMYCIN ®< ), tetracycline (SUMYCIN ®< , ACHROMYCIN ®< V, STECLIN ®< )), drugs against mycobacteria (e.g., clofazimine (LAMPRENE ®< ), dapsone (AVLOSULFON ®< ), capreomycin (CAPASTAT ®< ), cycloserine (SEROMYCIN ®< ), ethambutol (MYAMBUTOL ®< ), ethionamide (TRECATOR ®< ), isoniazid (I.N.H. ®< ), pyrazinamide (ALDINAMIDE ®< ), rifampin (RIFADIN ®< , RIMACTANE ®< ), rifabutin (MYCOBUTIN ®< ), rifapentine (PRIFTIN ®< ), streptomycin), and others (e.g., arsphenamine (SALVARSAN ®< ), chloramphenicol (CHLOROMYCETIN ®< ), fosfomycin (MONUROL ®< ), fusidic acid (FUCIDIN ®< ), linezolid (ZYVOX ®< ), metronidazole (FLAGYL ®< ), mupirocin (BACTROBAN ®< ), platensimycin, quinupristin / dalfopristin (SYNERCID ®< ), rifaximin (XIFAXAN ®< ), thiamphenicol, tigecycline (TIGACYL ®< ), tinidazole (TINDAMAX ®< , FASIGYN ®< )).B. Therapeutic Settings and / or Situations

[0092] NAVs of the present invention may be utilized in various settings depending on the prevalence of the infection or the degree or level of unmet medical need. Some applications of the NAVs of the disclosure are outlined in Table 1. Table 1. Infectious Agents by prevalence and Medical Need Unmet Need (Infectious Agent Target) Prevalence Short term benign Long term sequelae Short term morbidity but some treatment Short term mortality; no treatment available Ubiquitous HPV, HCV, UTRIsDengue, Chikungunya, ETEC and GI bacteria and S. Pneumo PNAseasonal and pandemic influenza, MRSA and TBAt risk populations VZV, Lyme and Chlamydia, N. gonorrhea and HSVNoroviruses, HEV, CMV, HIV and N. meningitisKlebsiella, Pseudomonas, Rabies and C. difficileRare disease --VEVtoxin-mediated diseases, hantavirus, arborviruses such as JE, WNV and EEECertain abbreviations include: HPV ― Human Papillomavirus; HCV ― Hepatitis C Virus; HEV - Human Enterovirus; MERS-CoV: Middle East Respiratory Syndrom Corona Virus; VZV ― Varicella-zoster Virus; MRSA ― Methicillin-resistant Staph areus; TB—tuberculosis; WNV—West Nile Virus; VEV--vesicular exanthema virus; EEE—Eastern equine encephalitis, JE—Japanese encephalitis, ETEC— Enterotoxigenic E. coli. Influenza (seasonal and pandemic)

[0093] Symptoms of the flu include dry cough, fever, chills, myalgias progressing to respiratory failure and the risk of secondary bacterial infections (e.g., MRSA). Seasonal influenza is ubiquitous and consists of three principal strains (A [H1N1], A [H3N2], and B), which are covered by the annual vaccine. Pandemic flu occurs because the viruses' unique reassortment ability allowing antigenic shift as well as transfer between avian and swine flu strains. One emerging concern in Southeast Asia is the pandemic potential of several new strains. Such pandemic outbreaks have a high mortality rate with few available treatments. Anti-virals only provide symptomatic relief and must be given in the first 48 hours.

[0094] The NAVs of the present invention have superior properties in that they produce much larger antibody titers, produce responses early than commercially available anti-virals and may be administered after the critical 48 hour period while retaining efficacy.

[0095] While not wishing to be bound by theory, the inventors hypothesize that the NAVs of the invention, as mRNA polynucleotides, are better designed to produce the appropriate protein conformation on translation as the NAVs co-opt natural cellular machinery. Unlike tranditional vaccines which are manufactured ex vivo and may trigger unwanted cellular responses, the NAVs are presented to the cellular system in amore native fashion. Adding to the superior effects may also involve the formulations utilized which may enither serve to shield or traffic the NAVs.

[0096] According to the present invention, NAVs represent a tailored active vaccine that not only can prevent infection but can limit transmission of influenza.

[0097] The NAVs of the invention may prevent pandemic influenza by reacting to emerging new strains with the very rapid NAV-based vaccine production process. In some embodiments, new NAV for treating or prophylactically preventing influenza outbreaks, including for emerging strains (e.g., H7N9 and H10N8), may be produced in less than six weeks, from the time of antigen identification to available vaccine.

[0098] In some instances, a single injection of a single antigen encoding NAV polynucleotide may provide protection for an entire flu season.Influenza: Maintenance of Antigenic memory

[0099] The NAV compositions of the present invention may also be used to maintain or restore antigenic memory in a subject or population as part of a vaccination plan.

[0100] With the speed and versatility of the NAV technology of the present invention, it is now possible to create a vaccination plan that spans both temporal and viral strain space.

[0101] In one embodiment, NAV compositions may be created which include polynucleotides that encode one or more flu year antigens. As used herein a flu year antigen is an antigen which is selected from a strain of influenza used as a component of a flu vaccine from a particular year. For example, the influenza A strain, A / Port Chalmers / 1 / 1973(H3N2)-like virus, represents one strain component of the Northern Hemisphere vaccine from 1974-1975.

[0102] According to the present disclosure a vaccination scheme or plan is developed which allows for not only ongoing vaccination in the current year but antigenic memory booster vaccinations across years, strains, or groups thereof to establish and maintain antigenic memory in a population. In this manner, a population is less likely to succumb to any pandemic or outbreak involving recurrence of older strains or the appearance of antigens from older strains.

[0103] Any combination of prior vaccine component strains utilized to create or design an antigenic memory booster vaccine is referred to here as a reference set.

[0104] In one instance, NAVs which are antigenic memory booster vaccines are administered to boost antigenic memory across a time period of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50 or more years.

[0105] In one instance, NAVs which are antigenic memory booster vaccines are administered to boost antigenic memory for alternating historic years including every other year from the past vaccine component strains relative to a current year. In some instances the selection of the vaccine components can be from every 3 rd< , 4 th< , 5 th< , 6 th< , 7 th< , 8 th< , 9 th< , 10 th< or more years.

[0106] In one instance, NAVs which are antigenic memory booster vaccines are administered to boost antigenic memory over ten year periods.

[0107] In some instances, NAVs which are antigenic memory booster vaccines are administered to boost antigenic memory and are selected from a number of influenza type A strains as a first selection combined with a selection from a number of influenza type B strains or other strains listed herein. The number of selections of type A or type B may be independently, 1, 2, 1, 4, 5, 6, 7, 8, 9, 10 or more.

[0108] In all cases, the antigenic memory booster vaccine strains for antigen encoding in the NAVs may be selected from either the Northern or Southern hemisphere vaccine components independently.

[0109] In some instances, the NAV booster vaccine may be used in a population either once or periodically to create herd immunity. Such immunity is present when greater than 30% of a population is protected.

[0110] The components or strains of influenza which may be utilized in the antigenic memory booster vaccines include, but are not limited to, those in Tables 2-5. Table 2. Influenza vaccine components by year Northern hemisphere H1N1 H3N2 B-strain additional B-strain for QIV 1974-1975N / AA / Port Chalmers / 1 / 1973(H 3N2)-like virusB / HongKong / 05 / 1 972-like virusN / A1975-1976A / Scotland / 840 / 74-like virus H1N1A / Port Chalmers / 1 / 1973(H 3N2)-like virusB / HongKong / 05 / 1 972-like virusN / A1976-1977N / AA / Victoria / 3 / 75(H3 N2)-like virusB / HongKong / 05 / 1 972-like virusN / A1977-1978N / AA / Victoria / 3 / 75(H3 N2)-like virusB / HongKong / 05 / 1 972-like virusN / A1978-1979A / USSR / 90 / 77(H1N 1)-like virusA / Texas / 1 / 77(H3N2 )-like virusB / HongKong / 05 / 1 972-like virusN / A1979-1980A / USSR / 90 / 77(H1N 1)-like virusA / Texas / 1 / 77(H3N2 )-like virusN / AN / A1980-1981A / Brazil / 11 / 78(H1N 1)-like virusA / Bangkok / 01 / 1979 (H3N2)-like virusB / Singapore / 222 / 7 9-like virusN / A1981-1982A / Brazil / 11 / 78(H1N 1)-like virusA / Bangkok / 01 / 1979 (H3N2)-like virusB / Singapore / 222 / 7 9-like virusN / A1982-1983A / Brazil / 11 / 78(H1N 1)-like virusA / Bangkok / 01 / 1979 (H3N2)-like virusB / Singapore / 222 / 7 9-like virusN / A1983-1984A / Brazil / 11 / 78(H1N 1)-like virusA / Philippines / 2 / 82( H3N2)-like virusB / Singapore / 222 / 7 9-like virusN / A1984-1985A / Chile / 1 / 83 (H1N1) -like virusA / Philippines / 2 / 82( H3N2)-like virusB / USSR / 100 / 83-like virusN / A1985-1986A / Chile / 1 / 83 (H1N1) -like virusA / Philippines / 2 / 82( H3N2)-like virusB / USSR / 100 / 83-like virusN / A1986-1987A / Chile / 1 / 83 (H1N1) -like virusA / Christchurch / 4 / 19 85(H3N2)-like virus and A / Mississippi / 1 / 85( H3N2)-like virusB / Ann Arbor / 1 / 86-like virusN / A1987-1988A / Singapore / 6 / 1986 (H1N1)-like virusA / Leningrad / 360 / 19 86(H3N2)-like strainN / AN / A1988-1989A / Singapore / 6 / 1986 (H1N1)-like virusA / Sichuan / 02 / 87(H3 N2)-like virusB / Beijing / 1 / 87-like rivusN / A1989-1990A / Singapore / 6 / 1986 (H1N1)-like virusA / Shanghai / 11 / 87(H 3N2)-like virusB / Yamagata / 16 / 88-like virusN / A1990-1991A / Singapore / 6 / 1986 (H1N1)-like virusA / Guizhou / 54 / 89(H 3N2)-like virusB / Yamagata / 16 / 88-like virusN / A1991-1992A / Singapore / 6 / 1986 (H1N1)-like virusA / Beijing / 353 / 89(H 3N2)-like virusB / Yamagata / 16 / 88-like virusN / A1992-1993N / AA / Beijing / 353 / 89(H 3N2)-like virusB / Yamagata / 16 / 88-like virusN / A1993-1994A / Singapore / 6 / 1986 (H1N1)-like virusA / Beijing / 32 / 92(H3 N2)-like virusB / Panama / 45 / 90-like virusN / A1994-1995A / Singapore / 6 / 1986 (H1N1)-like virusA / Shangdong / 9 / 93( H3N2)-like virusB / Panama / 45 / 90-like virusN / A1995-1996A / Singapore / 6 / 1986 (H1N1)-like virusA / Johannesburg / 33 / 94(H3N2)-like virusB / Beijing / 184 / 93-like virusN / A1996-1997A / Singapore / 6 / 1986 (H1N1)-like virusA / Wuhan / 359 / 95(H 3N2)-like virusB / Beijing / 184 / 93-like virusN / A1997-1998A / Bayern / 7 / 95(H1N 1)-like virusA / Wuhan / 359 / 95 (H3N2)-like virusB / Beijing / 184 / 93-like virusN / A Table 3. Influenza vaccine components by year-Southern Hemisphere Southern Hemisphere H1N1 H3N2 B-strain additional B-strain for QIV 1975N / AA / Port Chalmers / 1 / 1973(H 3N2)-like virusB / HongKong / 05 / 1 972-like virusN / A1976A / Scotland / 840 / 74- like virus (H1N1)A / Port Chalmers / 1 / 1973(H 3N2)-like virusB / HongKong / 05 / 1 972-like virusN / A1977N / AA / Victoria / 3 / 75(H3 N2)-like virusB / HongKong / 05 / 1 972-like virusN / A1978N / AA / Victoria / 3 / 75(H3 N2)-like virusB / HongKong / 05 / 1 972-like virusN / A1979A / USSR / 90 / 77(H1N 1)-like virusA / Texas / 1 / 77(H3N2 )-like virusB / HongKong / 05 / 1 972-like virusN / A1980A / USSR / 90 / 77(H1N 1)-like virusA / Texas / 1 / 77(H3N2 )-like virusN / AN / A1981A / Brazil / 11 / 78(H1N 1)-like virusA / Bangkok / 01 / 1979 (H3N2)-like virusB / Singapore / 222 / 7 9-like virusN / A1982A / Brazil / 11 / 78(H1N 1)-like virusA / Bangkok / 01 / 1979 (H3N2)-like virusB / Singapore / 222 / 7 9-like virusN / A1983A / Brazil / 11 / 78(H1N 1)-like virusA / Bangkok / 01 / 1979 (H3N2)-like virusB / Singapore / 222 / 7 9-like virusN / A1984A / Brazil / 11 / 78(H1N 1)-like virusA / Philippines / 2 / 82( H3N2)-like virusB / Singapore / 222 / 7 9-like virusN / A1985A / Chile / 1 / 83 (H1N1) -like virusA / Philippines / 2 / 82( H3N2)-like virusB / USSR / 100 / 83-like virusN / A1986A / Chile / 1 / 83 (H1N1) -like virusA / Philippines / 2 / 82( H3N2)-like virusB / USSR / 100 / 83-like virusN / A1987A / Chile / 1 / 83 (H1N1) -like virusA / Christchurch / 4 / 19 85(H3N2)-like virus and A / Mississippi / 1 / 85( H3N2)-like virusB / Ann Arbor / 1 / 86-like virusN / A1988A / Singapore / 6 / 1986 (H1N1)-like virusA / Leningrad / 360 / 19 86(H3N2)-like virusN / AN / A1989A / Singapore / 6 / 1986 (H1N1)-like virusA / Sichuan / 02 / 87(H3 N2)-like virusB / Beijing / 1 / 87-fike virusN / A1990A / Singapore / 6 / 1986 (H1N1)-like virusA / Shanghai / 11 / 87(H 3N2)-like virusB / Yamagata / 16 / 88-like virusN / A1991A / Singapore / 6 / 1986 (H1N1)-like virusA / Guizhou / 54 / 89(H3N2)-like virusB / Yamagata / 16 / 88-like virusN / A1992A / Singapore / 6 / 1986 (H1N1)-like virusA / Beijing / 353 / 89(H 3N2)-like virusB / Yamagata / 16 / 88-like virusN / A1993A / Singapore / 6 / 1986 (H1N1)-like virusA / Beijing / 353 / 89(H 3N2)-like virusB / Yamagata / 16 / 88-like virusN / A1994A / Singapore / 6 / 1986 (H1N1)-like virusA / Beijing / 32 / 92(H3 N2)-like virusB / Panama / 45 / 90-like virusN / A1995A / Singapore / 6 / 1986 (H1N1)-like virusA / Shangdong / 9 / 93( H3N2)-like virusB / Panama / 45 / 90-like virusN / A1996A / Singapore / 6 / 1986 (H1N1)-like virusA / Johannesburg / 33 / 94(H3N2)-like virusB / Beijing / 184 / 93-like virusN / A1997A / Singapore / 6 / 1986 (H1N1)-like virus3N2)-like virusB / Beijing / 184 / 93-like strainN / A1998A / Bayern / 7 / 95(H1N 1)-like virus3N2)-like virusB / Beijing / 184 / 93-like virusN / A1999A / Beijing / 262 / 95(H 1N1)-like virusA / Sydney / 5 / 97(H3N 2)-like virusB / Beijing / 184 / 93-like virusN / A Table 4. Influenza Vaccine components by year-Northern Hemisphere Northern hemisphere H1N1 H3N2 B-strain additional B-strain for QIV November 1998-April 1999A / Beijing / 262 / 95(H 1N1)-like virusA / Sydney / 5 / 97(H3N 2)-like virusB / Beijing / 184 / 93-like virusN / ANovember 1999-April 2000A / Beijing / 262 / 95 (H1N1)-like virusA / Sydney / 5 / 97 (H3N2)-like virusB / Beijing / 184 / 93-like virus or B / Shangdong / 7 / 97-like virusN / A2000-2001A / New Caledonia / 20 / 99 (H1N1)-like virusA / Moscow / 10 / 99 (H3N2)-like virusB / Beijing / 184 / 93-like virusN / A2001-2002A / New Caledonia / 20 / 99(H 1 Nl)-like virusA / Moscow / 10 / 99(H 3N2)-like virusB / Sichuan / 379 / 99-like virusN / A2002-2003A / New Caledonia / 20 / 99(H1 Nl)-like virusA / Moscow / 10 / 99(H 3N2)-like virusB / Hong Kong / 330 / 2001-like virusN / A2003-2004A / New Caledonia / 20 / 99(H 1 Nl)-like virusA / Moscow / 10 / 99(H 3N2)-like virusB / Hong Kong / 330 / 2001-like virusN / A2004-2005A / New Caledonia / 20 / 99(H 1 Nl)-like virusA / Fujian / 411 / 2002( H3N2)-like virusB / Shanghai / 361 / 20 02-like virusN / A2005-2006A / New Caledonia / 20 / 99(H 1 Nl)-like virusA / California / 7 / 2004 (H3N2)-like virusB / Shanghai / 361 / 20 02-like virusN / A2006-2007A / New Caledonia / 20 / 99(H 1 Nl)-likeA / Wisconsin / 67 / 200 5 (H3N2)-like virusB / Malaysia / 2506 / 2 004-like virusN / A2007-2008A / Solomon Islands / 3 / 2006 (H1N1)-like virusA / Wisconsin / 67 / 200 5 (H3N2)-like virusB / Malaysia / 2506 / 2 004-like virusN / A2008-2009A / Brisbane / 59 / 2007 (H1N1)-like virusA / Brisbane / 10 / 2007 (H3N2)-like virusB / Florida / 4 / 2006-like virusN / A2009-2010A / Brisbane / 59 / 2007 (H1N1)-like virusA / Brisbane / 10 / 2007 (H3N2)-like virusB / Brisbane / 60 / 200 8-like virusN / A2010-2011A / California / 7 / 2009 (H1N1)-like virusA / Perth / 16 / 2009 (H3N2)-like virusB / Brisbane / 60 / 200 8-like virusN / A2011-2012A / California / 7 / 2009 (H1N1)-like virusA / Perth / 16 / 2009 (H3N2)-like virusB / Brisbane / 60 / 200 8-like virusN / A2012-2013A / California / 7 / 2009 (H1N1)pdm09-like virusA / Victoria / 361 / 2011 (H3N2)-like virusB / Wisconsin / 1 / 201 0-like virusB / Brisbane / 6 0 / 2008-like virus2013-2014A / California / 7 / 2009 (H1N1)pdm09-like virusA(H3N2) virus antigenically like the cell-propagated prototype virus A / Victoria / 361 / 2011B / Massachusetts / 2 / 2012-like virusB / Brisbane / 6 0 / 2008-like virus2014-2015A / California / 7 / 2009 (H1N1)pdm09-like virusA / Texas / 50 / 2012 (H3N2)-like virusB / Massachusetts / 2 / 2012-like virusB / Brisbane / 6 0 / 2008-like virus Table 5. Influenza Vaccine components by year-Southern Hemisphere Southern hemisphere H1N1 H3N2 B-strain additional B-strain for QIV 1999A / Beijing / 262 / 95(H 1N1)-like virusA / Sydney / 5 / 97(H3N 2)-like virusB / Beijing / 184 / 93-like virusN / AMay-October 2000A / New Caledonia / 20 / 99 (H1N1)-like virusA / Moscow / 10 / 99 (H3N2)-like virusB / Beijing / 184 / 93-like virus or B / Shangdong / 7 / 97-like virusN / AMay-October 2001A / New Caledonia / 20 / 99 (H1N1)-like virusA / Moscow / 10 / 99 (H3N2)-like virusB / Sichuan / 379 / 99-like virusN / A2002A / New Caledonia / 20 / 99(H1 Nl)-like virusA / Moscow / 10 / 99(H 3N2)-like virusB / Sichuan / 379 / 99-like virusN / A2003A / New Caledonia / 20 / 99(H1 Nl)-like virusA / Moscow / 10 / 99(H 3N2)-like virusB / Hong Kong / 330 / 2001-like virusN / A2004A / New Caledonia / 20 / 99(H1 Nl)-like virusA / Fujian / 411 / 2002( H3N2) - like virusB / Hong Kong / 330 / 2001-like virusN / A2005A / New Caledonia / 20 / 99(H1 Nl)-like virusA / Wellington / 1 / 200 4(H3N2)-like virusB / Shanghai / 361 / 20 02-like virusN / A2006A / New Caledonia / 20 / 99(H1 N1)-like virusA / California / 7 / 2004 (H3N2)-like virusB / Malaysia / 2506 / 2 004-like virusN / A2007A / New Caledonia / 20 / 99(H1 Nl)-likeA / Wisconsin / 67 / 200 5 (H3N2)-like virusB / Malaysia / 2506 / 2 004-like virusN / A2008A / Solomon Islands / 3 / 2006 (H1N1)-like virusA / Brisbane / 10 / 2007 (H3N2)-like virusB / Florida / 4 / 2006-like virusN / A2009A / Brisbane / 59 / 2007 (H1N1)-like virusA / Brisbane / 10 / 2007 (H3N2)-like virusB / Florida / 4 / 2006-like virusN / A2010A / California / 7 / 2009 (H1N1)-like virusA / Perth / 16 / 2009 (H3N2)-like virusB / Brisbane / 60 / 200 8-like virusN / A2011A / California / 7 / 2009 (H1N1)-like virusA / Perth / 16 / 2009 (H3N2)-like virusB / Brisbane / 60 / 200 8-like virusN / A2013A / California / 7 / 2009 (H1N1)pdm09 like virusA / Perth / 16 / 2009 (H3N2)-like virusB / Brisbane / 60 / 200 8-like virusN / A2013A / California / 7 / 2009 (H1N1)pdm09-fike virusA / Victoria / 361 / 2011 (H3N2)-like virusB / Wisconsin / 1 / 201 0-like virusB / Brisbane / 6 0 / 2008-like virus2014A / California / 7 / 2009 (H1N1)pdm09-fike virusA / Texas / 50 / 2012 (H3N2)-like virusB / Massachusetts / 2 / 2012-like virusB / Brisbane / 6 0 / 2008-like virus Influenza antigens

[0111] In some embodiments, the NAV polnynucleotides may encode one or more polypeptides of an influenza strain as an antigen. Such antigens include, but are not limited to those antigens encoded by the polynucleotides listed in Tables 6-18. In the table, the GenBank Accession Number represents either the complete or partial CDS of the encoded antigen. The NAV polynucleotides may comprise a region of any of the sequences listed in the tables or entire coding region of the mRNA listed. They may comprise hybrid or chimeric regions, or mimics or variants. In the invention, the antigenic popipeptide is a hemagglutinin protein or fragment thereof.

[0112] Any of the strains referred to in Tables 6-14 may also be used in an antigenic memory booster vaccine as described herein. Table 6. Influenza H1N1 Antigens Strain / Protein Length GenBank / GI Accession No. Influenza A virus (A / Bayern / 7 / 95(H1N1)) NA gene for neuraminidase, genomic RNA1,459 bp linear mRNAAJ518104.1 GI:31096418Influenza A virus (A / Brazil / 11 / 1978(X-71)(H1N1)) mRNA for hemagglutinin HA1, escape variant 11,072 bp linear mRNAX86654.1 GI:995549Influenza A virus (A / Brazil / 11 / 1978(X-71)(H1N1)) mRNA for hemagglutinin HA1, escape variant 21,072 bp linear mRNAX86655.1 GI:995550Influenza A virus (A / Brazil / 11 / 1978(X-71)(H1N1)) mRNA for hemagglutinin HA1, escape variant 31,072 bp linear mRNAX86656.1 GI:995551Influenza A virus (A / Brazil / 11 / 1978(X-71)(H1N1)) mRNA for hemagglutinin HA1, escape variant 41,072 bp linear mRNAX86657.1 GI:995552Influenza A virus (A / Brevig_Mission / 1 / 18(H1N1)) hemagglutinin (HA) mRNA, partial cds1,220 bp linear mRNAAF116575.1 GI:4325017Influenza A virus (A / Brevig_Mission / 1 / 18(H1N1)) neuraminidase (NA) gene, complete cds1,410 bp linear mRNAAF250356.2 GI:13260556Influenza A virus (A / Brevig Mission / 1 / 1918(H1N1)) nucleoprotein (np) mRNA, complete cds1,497 bp linear mRNAAY744935.1 GI:55273940Influenza A virus (A / Brevig Mission / 1 / 1918(H1N1)) polymerase PB2 (PB2) mRNA, complete cds2,280 bp linear mRNADQ208309.1 GI:76786704Influenza A virus (A / Brevig Mission / 1 / 1918(H1N1)) polymerase PB1 (PB1) mRNA, complete cds2,274 bp linear mRNADQ208310.1 GI:76786706Influenza A virus (A / Brevig Mission / 1 / 1918(H1N1)) polymerase PA (PA) mRNA, complete cds2,151 bp linear mRNADQ208311.1 GI:76786708Influenza A virus (A / camel / Mongolia / 1982(H1N1)) hemagglutinin mRNA, partial cds366 bp linear mRNAM73975.1 GI:324242Influenza A virus (A / camel / Mongolia / 1982(H1N1)) matrix protein mRNA, partial cds460 bp linear mRNAM73978.1 GI:324402Influenza A virus (A / camel / Mongolia / 1982(H1N1)) neuraminidase (NA) mRNA, partial cds310 bp linear mRNAM73976.1 GI:324579Influenza A Virus A / camel / Mongolia / 82 NS1 protein mRNA, partial cds273 bp linear mRNAM73977.1 GI:324768Influenza A virus (A / camel / mongolia / 1982(H1N1) PA polymerase mRNA, partial cds227 bp linear mRNAM73974.1 GI:324931Influenza A virus (A / camel / Mongolia / 1982(H1N1)) PB1 protein mRNA, partial cds531 bp linear mRNAM73973.1 GI:324971Influenza A Virus (A / camel / Mongolia / 82(H1N1)) polymerase 2 (P2) mRNA, partial cds379 bp linear mRNAM73972.1 GI:324993Influenza A virus (A / chicken / Hong Kong / 14 / 1976(H1N1)) hemagglutinin precursor (HA) mRNA, partial cds1,169 bp linear mRNAU46782.1 GI:1912328Influenza A virus (A / Chonnam / 07 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,452 bp linear mRNAAY297141.1 GI:31871990Influenza A virus (A / Chonnam / 07 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,137 bp linear mRNAAY297154.1 GI:32140347Influenza A virus (A / Chonnam / 18 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,458 bp linear mRNAAY297143.1 GI:31871994Influenza A virus (A / Chonnam / 18 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,176 bp linear mRNAAY297156.1 GI:32140355Influenza A virus (A / Chonnam / 19 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,458 bp linear mRNAAY310410.1 GI:31872389Influenza A virus (A / Chonnam / 19 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,167 bp linear mRNAAY299502.1 GI:32140392Influenza A virus (A / Chonnam / 51 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,443 bp linear mRNAAY310412.1 GI:31873090Influenza A virus (A / Chonnam / 51 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,161 bp linear mRNAAY299498.1 GI:32140384Influenza A virus (A / Chungbuk / 50 / 2002(H1N1)) neuraminidase (NA) mRNA, partial cds1,425 bp linear mRNAAY297150.1 GI:31872010Influenza A virus (A / Chungbuk / 50 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,161 bp linear mRNAAY299506.1 GI:32140400Influenza A virus (A / Denmark / 40 / 2000(H1N1)) NA gene for neuraminidase, genomic RNA1,458 bp linear mRNAAJ518095.1 GI:31096400Influenza A virus (A / Denver / 1 / 57(H1N1)) neuraminidase mRNA, partial cds379 bp linear mRNAAF305216.1 GI:10732818Influenza A virus (A / Denver / 1 / 57(H1N1)) matrix protein gene, partial cds442 bp linear mRNAAF305217.1 GI:10732820Influenza A virus (A / Denver / 1 / 57(H1N1)) hemagglutinin gene, partial cds215 bp linear mRNAAF305218.1 GI:10732822Influenza A virus (A / duck / Australia / 749 / 80(H1N1)) hemagglutinin precursor (HA) mRNA, partial cds981 bp linear mRNAU47309.1 GI:1912348Influenza A virus (A / duck / Australia / 749 / 80(H1N1)) segment 4 hemagglutinin precursor (HA) mRNA, complete cds1,777 bp linear mRNAAF091312.1 GI:4585166Influenza A virus (A / duck / Bavaria / 1 / 77 (H1N1)) segment 4 hemagglutinin precursor (HA) mRNA, complete cds1,777 bp linear mRNAAF091313.1 GI:4585168Influenza A virus (A / duck / Bavaria / 2 / 77(H1N1)) hemagglutinin precursor (HA) mRNA, partial cds981 bp linear mRNAU47308.1 GI:1912346Influenza A virus (A / duck / Eastern China / 103 / 2003(H1N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,458 bp linear mRNAEU429749.1 GI:167859463Influenza A virus (A / duck / Eastern China / 152 / 2003(H1N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,461 bp linear mRNAEU429751.1 GI:167859467Influenza A virus (A / Duck / Ohio / 118C / 93 (H1N1)) neuraminidase (NA) gene, complete cds1,410 bp linear mRNAAF250361.2 GI:13260576Influenza A virus (A / Duck / Ohio / 175 / 86 (H1N1)) neuraminidase (NA) gene, complete cds1,410 bp linear mRNAAF250358.2 GI:13260565Influenza A virus (A / Duck / Ohio / 194 / 86 (H1N1)) neuraminidase (NA) gene, complete cds1,410 bp linear mRNAAF250360.2 GI:13260573Influenza A virus (A / Duck / Ohio / 30 / 86 (H1N1)) neuraminidase (NA) gene, complete cds1,410 bp linear mRNAAF250359.2 GI:13260570Influenza A virus strain A / Fiji / 15899 / 83(H1N1) mRNA for neuraminidase1,460 bp linear mRNAAJ006954.1 GI:4210707Influenza A Virus (A / Fiji / 15899 / 83(H1N1)) mRNA for PB2 protein2,341 bp linear mRNAAJ564805.1 GI:31442134Influenza A Virus (A / Fiji / 15899 / 83(H1N1)) partial mRNA for PB1 protein2,113 bp linear mRNAAJ564807.1 GI:31442138Influenza A virus (A / FM / 1 / 47 (H1N1)) neuraminidase (NA) gene, complete cds1,395 bp linear mRNAAF250357.2 GI:13260561Influenza A virus (A / goose / Hong Kong / 8 / 1976(H1N1)) hemagglutinin precursor (HA) mRNA, partial cds1,091 bp linear mRNAU46021.1 GI:1912326Influenza A virus (A / goose / Hong Kong / 8 / 1976(H1N1)) polymerase (PB1) mRNA, partial cds261 bp linear mRNAU48284.1 GI:1912372Influenza A virus (A / goose / Hong Kong / 8 / 1976(H1N1)) nucleoprotein (NP) mRNA, partial cds1,395 bp linear mRNAU49093.1 GI:1912384Influenza A virus (A / Guangzhou / 1561 / 2006(H1N1)) segment 4 hemagglutinin (HA) mRNA, complete cds1,775 bp linear mRNAEU382986.1 GI:170762603Influenza A virus (A / Guangzhou / 1561 / 2006(H1N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,462 bp linear mRNAEU382993.1 GI:170762617Influenza A virus (A / Guangzhou / 1684 / 2006(H1N1)) segment 4 hemagglutinin (HA) mRNA, complete cds1,775 bp linear mRNAEU382987.1 GI:170762605Influenza A virus (A / Guangzhou / 1684 / 2006(H1N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,462 bp linear mRNAEU382994.1 GI:170762619Influenza A virus (A / Guangzhou / 483 / 2006(H1N1)) segment 4 hemagglutinin (HA) mRNA, complete cds1,775 bp linear mRNAEU382981.1 GI:170762593Influenza A virus (A / Guangzhou / 483 / 2006(H1N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,462 bp linear mRNAEU382988.1 GI:170762607Influenza A virus (A / Guangzhou / 506 / 2006(H1N1)) segment 4 hemagglutinin (HA) mRNA, complete cds1,775 bp linear mRNAEU382982.1 GI:170762595Influenza A virus (A / Guangzhou / 506 / 2006(H1N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,461 bp linear mRNAEU382989.1 GI:170762609Influenza A virus (A / Guangzhou / 555 / 2006(H1N1)) segment 4 hemagglutinin (HA) mRNA, complete cds1,775 bp linear mRNAEU382983.1 GI:170762597Influenza A virus (A / Guangzhou / 555 / 2006(H1N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,462 bp linear mRNAEU382990.1 GI:170762611Influenza A virus (A / Guangzhou / 657 / 2006(H1N1)) segment 4 hemagglutinin (HA) mRNA, complete cds1,775 bp linear mRNAEU382984.1 GI:170762599Influenza A virus (A / Guangzhou / 657 / 2006(H1N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,462 bp linear mRNAEU382991.1 GI:170762613Influenza A virus (A / Guangzhou / 665 / 2006(H1N1)) segment 4 hemagglutinin (HA) mRNA, complete cds1,775 bp linear mRNAEU382985.1 GI:170762601Influenza A virus (A / Guangzhou / 665 / 2006(H1N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,462 bp linear mRNAEU382992.1 GI:170762615Influenza A virus (A / Gwangju / 55 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,431 bp linear mRNAAY297151.1 GI:31872012Influenza A virus (A / Gwangju / 55 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,179 bp linear mRNAAY299507.1 GI:32140402Influenza A virus (A / Gwangju / 57 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,446 bp linear mRNAAY297152.1 GI:31872014Influenza A virus (A / Gwangju / 57 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,167 bp linear mRNAAY299508.1 GI:32140404Influenza A virus (A / Gwangju / 58 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,434 bp linear mRNAAY297153.1 GI:31872016Influenza A virus (A / Gwangju / 58 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,176 bp linear mRNAAY299509.1 GI:32140406Influenza A virus (A / Gwangju / 90 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,446 bp linear mRNAAY297147.1 GI:31872002Influenza A virus (A / Gwangju / 90 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,164 bp linear mRNAAY299499.1 GI:32140386Influenza A virus (A / Hong Kong / 437 / 2002(H1N1)) partial NA gene for neuraminidase, genomic RNA1,403 bp linear mRNAAJ518101.1 GI:31096412Influenza A virus (A / Hong Kong / 747 / 2001(H1N1)) partial NA gene for neuraminidase, genomic RNA1,352 bp linear mRNAAJ518102.1 GI:31096414Influenza A virus (A / London / 1 / 1918(H1N1)) hemagglutinin (HA) mRNA, partial cds563 bp linear mRNAAY184805.1 GI:32395285Influenza A virus (A / London / 1 / 1919(H1N1)) hemagglutinin (HA) mRNA, partial cds563 bp linear mRNAAY184806.1 GI:32395287Influenza A virus (A / Loygang / 4 / 1957(H1N1)) nucleoprotein mRNA, complete cds1,565 bp linear mRNAM76604.1 GI:324255Influenza A virus (A / Lyon / 651 / 2001(H1N1)) partial NA gene for neuraminidase, genomic RNA1,318 bp linear mRNAAJ518103.1 GI:31096416Influenza A virus (A / mallard / Alberta / 119 / 98 (H1N1)) nonfunctional matrix protein mRNA, partial sequence947 bp linear mRNAAY664487.1 GI:51011891Influenza A virus (A / duck / Alberta / 35 / 76(H1N1)) hemagglutinin precursor (HA) mRNA, partial cds981 bp linear mRNAU47310.1 GI:1912350Influenza A virus (A / duck / Alberta / 35 / 76(H1N1)) segment 4 hemagglutinin precursor (HA) mRNA, complete cds1,777 bp linear mRNAAF091309.1 GI:4585160Influenza A virus (A / duck / Alberta / 35 / 76(H1N1)) neuraminidase (NA) gene, complete cds1,410 bp linear mRNAAF250362.2 GI:13260579Influenza A virus (A / mallard / Tennessee / 11464 / 85 (H1N1)) hemagglutinin precursor (HA) mRNA, partial cds981 bp linear mRNAU47307.1 GI:1912344Influenza A virus (A / mallard / Tennessee / 11464 / 85 (H1N1)) segment 4 hemagglutinin precursor (HA) mRNA, complete cds1,777 bp linear mRNAAF091311.1 GI:4585164Influenza A virus (A / New Caledonia / 20 / 1999(H1N1)) segment 7 matrix protein 2 (M2) mRNA, complete cds294 bp linear mRNAHQ008884.1 GI:302566794Influenza A virus (A / New Jersey / 4 / 1976(H1N1)) nucleoprotein mRNA, complete cds1,565 bp linear mRNAM76605.1 GI:324581Influenza A virus (A / New Jersey / 8 / 1976(H1N1)) nucleoprotein mRNA, complete cds1,565 bp linear mRNAM76606.1 GI:324583Influenza A virus (A / New_York / 1 / 18(H1N1)) hemagglutinin (HA) mRNA, partial cds1,220 bp linear mRNAAF116576.1 GI:4325019Influenza A virus (A / Ohio / 3523 / 1988(H1N1)) nucleoprotein mRNA, complete cds1,565 bp linear mRNAM76602.1 GI:324889Influenza A virus (A / Pusan / 22 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,455 bp linear mRNAAY310411.1 GI:31872391Influenza A virus (A / Pusan / 22 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,149 bp linear mRNAAY299503.1 GI:32140394Influenza A virus (A / Pusan / 23 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,440 bp linear mRNAAY297144.1 GI:31871996Influenza A virus (A / Pusan / 23 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,158 bp linear mRNAAY297157.1 GI:32140357Influenza A virus (A / Pusan / 24 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,449 bp linear mRNAAY297145.1 GI:31871998Influenza A virus (A / Pusan / 24 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,128 bp linear mRNAAY299494.1 GI:32140376Influenza A virus (A / Pusan / 44 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,431 bp linear mRNAAY297148.1 GI:31872004Influenza A virus (A / Pusan / 44 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,167 bp linear mRNAAY299504.1 GI:32140396Influenza A virus (A / Pusan / 45 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,434 bp linear mRNAAY297146.1 GI:31872000Influenza A virus (A / Pusan / 45 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,167 bp linear mRNAAY299496.1 GI:32140380Influenza A virus (A / Pusan / 46 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,422 bp linear mRNAAY310408.1 GI:31872385Influenza A virus (A / Pusan / 46 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,176 bp linear mRNAAY299497.1 GI:32140382Influenza A virus (A / Pusan / 47 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,437 bp linear mRNAAY297149.1 GI:31872008Influenza A virus (A / Pusan / 47 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,170 bp linear mRNAAY299505.1 GI:32140398Influenza A virus (A / Saudi Arabia / 7971 / 2000(H1N1)) partial NS1 gene for non structural protein 1 and partial NS2 gene for non structural protein 2, genomic RNA789 bp linear mRNAAJ519463.1 GI:31096450Influenza A virus (A / Seoul / 11 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,452 bp linear mRNAAY297142.1 GI:31871992Influenza A virus (A / Seoul / 11 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,176 bp linear mRNAAY297155.1 GI:32140349Influenza A virus (A / Seoul / 13 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,452 bp linear mRNAAY310409.1 GI:31872387Influenza A virus (A / Seoul / 13 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,167 bp linear mRNAAY299500.1 GI:32140388Influenza A virus (A / Seoul / 15 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,449 bp linear mRNAAY297140.1 GI:31871988Influenza A virus (A / Seoul / 15 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,149 bp linear mRNAAY299501.1 GI:32140390Influenza A virus (A / Seoul / 33 / 2002(H1N1)) neuraminidase (NA) mRNA, complete cds1,437 bp linear mRNAAY310407.1 GI:31872383Influenza A virus (A / Seoul / 33 / 2002(H1N1)) hemagglutinin (HA) mRNA, partial cds1,167 bp linear mRNAAY299495.1 GI:32140378Influenza A virus (A / swine / Arnsberg / 6554 / 1979(H1N1)) mRNA for hemagglutinin HA11,050 bp linear mRNAZ46437.1 GI:565609Influenza A virus (A / swine / Beijing / 47 / 1991(H1N1)) hemagglutinin precursor (HA) mRNA, partial cds1,595 bp linear mRNAU46783.1 GI:1912330Influenza A virus (A / swine / Beijing / 94 / 1991(H1N1)) nucleoprotein (NP) mRNA, complete cds1,565 bp linear mRNAU49091.1 GI:1912380Influenza A virus (A / swine / Belgium / 1 / 83(H1N1)) segment 4 hemagglutinin precursor (HA) mRNA, complete cds1,778 bp linear mRNAAF091316.1 GI:4585174Influenza A virus (A / swine / Cotes d'Armor / 0118 / 2006(H1N1)) partial mRNA for haemagglutinin precursor (HA1 gene)1,116 bp linear mRNAAM490219.1 GI:222062898Influenza A virus (A / swine / Cotes d'Armor / 0136_18 / 2006(H1N1)) partial mRNA for haemagglutinin precursor (HA1 gene)1,043 bp linear mRNAAM490223.1 GI:222062906Influenza A virus (A / swine / Cotes d'Armor / 0184 / 2006(H1N1)) partial mRNA for haemagglutinin precursor (HA1 gene)1,089 bp linear mRNAAM490220.1 GI:222062900Influenza A virus (A / swine / Cotes d'Armor / 0227 / 2005(H1N1)) partial mRNA for haemagglutinin precursor (HA1 gene)1,068 bp linear mRNAAM490221.1 GI:222062902Influenza A virus (A / swine / Cotes d'Armor / 0250 / 2006(H1N1)) partial mRNA for haemagglutinin precursor (HA1 gene)1,024 bp linear mRNAAM490222.1 GI:222062904Influenza A virus (A / swine / Cotes d'Armor / 736 / 2001(H1N1)) partial HA gene for Haemagglutinin, genomic RNA1,011 bp linear mRNAAJ517820.1 GI:38422533Influenza A virus (A / Swine / England / 195852 / 92 (H1N1)) neuraminidase (NA) gene, complete cds1,410 bp linear mRNAAF250366.2 GI:13260593Influenza A virus PB2 gene for Polymerase 2 protein, genomic RNA, strain A / Swine / Finistere / 2899 / 822,268 bp linear mRNAAJ311457.1 GI:13661037Influenza A virus PB1 gene for Polymerase 1 protein, genomic RNA, strain A / Swine / Finistere / 2899 / 822,341 bp linear mRNAAJ311462.1 GI:13661047Influenza A virus PA gene for Polymerase A protein, genomic RNA, strain A / Swine / Finistere / 2899 / 822,233 bp linear mRNAAJ311463.1 GI:13661049Influenza A virus (A / swine / Finistere / 2899 / 82(H1N1) M1 gene for matrix protein 1 and M2 gene for matrix protein 2, genomic RNA1,002 bp linear mRNAAJ316059.1 GI:20068128Influenza A virus (A / swine / Finistere / 2899 / 82(H1N1)) NS1 gene for non structural protein 1 and NS2 gene for non structural protein 2, genomic RNA864 bp linear mRNAAJ344037.1 GI:20068185Influenza A virus (A / swine / Germany / 2 / 1981(H1N1)) mRNA for PA polymerase838 bp linear mRNAX75786.1 GI:438106Influenza A virus (A / swine / Germany / 2 / 1981(H1N1)) mRNA for neuraminidase (partial)305 bp linear mRNAZ30277.1 GI:530399Influenza A virus (A / swine / Germany / 2 / 1981(H1N1)) mRNA for hemagglutinin1,730 bp linear mRNAZ30276.1 GI:563490165. Influenza A virus (A / swine / Germany / 8533 / 1991(H1N1)) mRNA for hemagglutinin precursor1,730 bp linear mRNAZ46434.1 GI:565611Influenza A virus (A / swine / Guangdong / 711 / 2001(H1N1)) nonfunctional hemagglutinin (HA) mRNA, partial sequence1,690 bp linear mRNAAY852271.1 GI:60327789Influenza A virus (A / swine / Haseluenne / IDT2617 / 03(H1N1)) hemagglutinin mRNA, complete cds1,809 bp linear mRNAEU163946.1 GI:157679548Influenza A virus (A / swine / Hokkaido / 2 / 81 (H1N1)) hemagglutinin precursor (HA) mRNA, partial cds981 bp linear mRNAU47306.1 GI:1912342Influenza A virus (A / swine / Hokkaido / 2 / 81 (H1N1)) segment 4 hemagglutinin precursor (HA) mRNA, complete cds1,778 bp linear mRNAAF091306.1 GI:4585154Influenza A virus (A / swine / Hong Kong / 168 / 1993(H1N1)) hemagglutinin precursor (HA) mRNA, partial cds1,113 bp linear mRNAU44482.1 GI:1912318Influenza A virus (A / swine / Hong Kong / 168 / 1993(H1N1)) neuraminidase (NA) mRNA, partial cds416 bp linear mRNAU47817.1 GI:1912354Influenza A virus (A / swine / Hong Kong / 168 / 1993(H1N1)) polymerase (PB2) mRNA, partial cds286 bp linear mRNAU48286.1 GI:1912358Influenza A virus (A / swine / Hong Kong / 168 / 1993(H1N1)) polymerase (PB1) mRNA, partial cds379 bp linear mRNAU48283.1 GI:1912370Influenza A virus (A / swine / Hong Kong / 168 / 1993(H1N1)) polymerase (PA) mRNA, partial cds308 bp linear mRNAU48850.1 GI:1912376Influenza A virus (A / swine / Hong Kong / 168 / 1993(H1N1)) nucleoprotein (NP) mRNA, partial cds1,397 bp linear mRNAU49096.1 GI:1912390Influenza A virus (A / swine / Hong Kong / 172 / 1993(H1N1)) hemagglutinin precursor (HA) mRNA, partial cds1,315 bp linear mRNAU46020.1 GI:1912324Influenza A virus (A / swine / Hong Kong / 176 / 1993(H1N1)) hemagglutinin precursor (HA) mRNA, partial cds1,113 bp linear mRNAU45451.1 GI:1912320Influenza A virus (A / swine / Hong Kong / 273 / 1994(H1N1)) hemagglutinin precursor (HA) mRNA, partial cds1,330 bp linear mRNAU45452.1 GI:1912322Influenza A virus (A / swine / Hong Kong / 273 / 1994(H1N1)) neuraminidase (NA) mRNA, partial cds241 bp linear mRNAU47818.1 GI:1912356Influenza A virus (A / swine / Hong Kong / 2 73 / 1994(H1N1)) polymerase (PB2) mRNA, partial cds328 bp linear mRNAU48287.1 GI:1912360Influenza A virus (A / swine / Hong Kong / 2 73 / 1994(H1N1)) polymerase (PB1) mRNA, partial cds240 bp linear mRNAU48282.1 GI:1912368Influenza A virus (A / swine / Hong Kong / 2 73 / 1994(H1N1)) polymerase (PA) mRNA, partial cds336 bp linear mRNAU48851.1 GI:1912378Influenza A virus (A / swine / Hong Kong / 2 73 / 1994(H1N1)) nucleoprotein (NP) mRNA, partial cds1,422 bp linear mRNAU49092.1 GI:1912382Influenza A virus (A / swine / IDT / Re230 / 92hp(H1N1)) hemagglutinin mRNA, complete cds1,761 bp linear mRNAEU163947.1 GI:157679550Influenza A virus (A / swine / IN / 1726 / 1988(H1N1)) nucleoprotein (segment 5) mRNA, complete cds1,550 bp linear mRNAL46849.1 GI:954755Influenza A virus (A / swine / Iowa / 15 / 30(H1N1)) hemagglutinin precursor (HA) mRNA, partial cds981 bp linear mRNAU47305.1 GI:1912340Influenza A virus (A / swine / Iowa / 15 / 30 (H1N1)) segment 4 hemagglutinin precursor (HA) mRNA, complete cds1,778 bp linear mRNAAF091308.1 GI:4585158Influenza A virus (A / Swine / Iowa / 30 (H1N1)) neuraminidase (NA) gene, complete cds1,410 bp linear mRNAAF250364.2 GI:13260586Influenza A virus (A / swine / Iowa / 17672 / 88 (H1N1)) hemagglutinin precursor (HA) mRNA, partial cds981 bp linear mRNAU47304.1 GI:1912338Influenza A virus (A / swine / Italy / 3364 / 00(H1N1)) partial NS1 gene for non structural protein 1 and partial NS2 gene for non structural protein 2, genomic RNA864 bp linear mRNAAJ519462.1 GI:31096447Influenza A virus (A / swine / Italy-Virus / 671 / 87(H1N1)) segment 4 hemagglutinin precursor (HA) mRNA, complete cds1,777 bp linear mRNAAF091315.1 GI:4585172Influenza A Virus (A / swine / Italy / v.147 / 1981(H1N1)) mRNA for hemagglutinin HA11,028 bp linear mRNAZ46436.1 GI:854214Influenza A virus (A / swine / Morbihan / 0070 / 2005(H1N1)) partial mRNA for haemagglutinin precursor (HA1 gene)1,118 bp linear mRNAAM490218.1 GI:222062896Influenza A virus (A / swine / Nebraska / 1 / 92(H1N1)) HA protein mRNA, complete cds1,770 bp linear mRNAL09063.1 GI:290722Influenza A virus (A / swine / Nebraska / 1 / 1992(H1N1)) segment 5 nucleoprotein (NP) mRNA, complete cds1,550 bp linear mRNAL11164.1 GI:290724Influenza A virus (A / swine / Netherlands / 12 / 1985(H1N1)) hemagglutinin (HA) mRNA, partial cds981 bp linear mRNAU46943.1 GI:1912336Influenza A virus (A / swine / Netherlands / 12 / 85(H1N1)) segment 4 hemagglutinin precursor (HA) mRNA, complete cds1,776 bp linear mRNAAF091317.1 GI:4585176Influenza A virus (A / swine / Netherlands / 25 / 1980(H1N1)) mRNA for nucleoprotein539 bp linear mRNAX75791.1 GI:438105Influenza A virus (A / swine / Netherlands / 3 / 1980(H1N1)) hemagglutinin (HA) mRNA, partial cds981 bp linear mRNAU46942.1 GI:1912334Influenza A virus (A / swine / Netherlands / 3 / 80(H1N1)) segment 4 hemagglutinin precursor (HA) mRNA, complete cds1,778 bp linear mRNAAF091314.1 GI:4585170Influenza A virus (A / NJ / 11 / 76 (H1N1)) neuraminidase (NA) gene, complete cds1,410 bp linear mRNAAF250363.2 GI:13260583Influenza A virus (A / Swine / Quebec / 192 / 81 (SwQc81)) neuraminidase mRNA, complete cds1,438 bp linear mRNAU86144.1 GI:4099318Influenza A virus (A / Swine / Quebec / 5393 / 91 (SwQc91)) neuraminidase mRNA, complete cds1,438 bp linear mRNAU86145.1 GI:4099320Influenza A virus (A / swine / Schleswig-Holstein / 1 / 1992(H1N1)) mRNA for hemagglutinin precursor1,730 bp linear mRNAZ46435.1 GI:854216Influenza A Virus (A / swine / Schleswig-Holstein / 1 / 1993(H1N1)) mRNA for nucleoprotein1,554 bp linear mRNAZ46438.1 GI:854222Influenza A virus (A / swine / Wisconsin / 1 / 61(H1N1)) segment 4 hemagglutinin precursor (HA) mRNA, complete cds1,778 bp linear mRNAAF091307.1 GI:4585156212. Influenza A virus (A / swine / Wisconsin / 1 / 1967(H1N1)) nucleoprotein mRNA, complete cds1,565 bp linear mRNAM76607.1 GI:325086Influenza A virus (A / swine / Wisconsin / 1915 / 1988(H1N1)) nucleoprotein mRNA, complete cds1,565 bp linear mRNAM76608.1 GI:325088Influenza A virus (A / swine / WI / 1915 / 1988(H1N1)) nucleoprotein (segment 5) mRNA, complete cds1,550 bp linear mRNAL46850.1 GI:954757Influenza A virus (A / Switzerland / 8808 / 2002(H1N1)) partial m1 gene for matrix protein 1 and partial m2 gene for matrix protein 2, genomic RNA729 bp linear mRNAAJ532568.1 GI:31096461Influenza A virus (A / human / Taiwan / 0012 / 00(H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAF362803.1 GI:14571975Influenza A virus (A / human / Taiwan / 0016 / 00(H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAF362779.1 GI:14571927Influenza A virus (A / Taiwan / 0016 / 2000 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303752.1 GI:32330993Influenza A virus (A / human / Taiwan / 0030 / 00(H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAF362780.1 GI:14571929Influenza A virus (A / Taiwan / 0030 / 2000 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303704.1 GI:32330897Influenza A virus (A / Taiwan / 0032 / 2002(H1N1)) hemagglutinin mRNA, partial cds494 bp linear mRNAAY604804.1 GI:50727488Influenza A virus (A / Taiwan / 0061 / 2002(H1N1)) hemagglutinin mRNA, partial cds494 bp linear mRNAAY604795.1 GI:50727470Influenza A virus (A / Taiwan / 0069 / 2002(H1N1)) hemagglutinin mRNA, partial cds494 bp linear mRNAAY604803.1 GI:50727486Influenza A virus (A / Taiwan / 0078 / 2002(H1N1)) hemagglutinin mRNA, partial cds494 bp linear mRNAAY604805.1 GI:50727490Influenza A virus (A / Taiwan / 0094 / 2002(H1N1)) hemagglutinin mRNA, partial cds494 bp linear mRNAAY604797.1 GI:50727474Influenza A virus (A / Taiwan / 0116 / 2002(H1N1)) hemagglutinin mRNA, partial cds494 bp linear mRNAAY604796.1 GI:50727472Influenza A virus (A / human / Taiwan / 0130 / 96(H1N1)) hemagglutinin (HA) mRNA, partial cds564 bp linear mRNAAF362781.1 GI:14571931Influenza A virus (A / Taiwan / 0130 / 96 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303707.1 GI:32330903Influenza A virus (A / human / Taiwan / 0132 / 96(H1N1)) hemagglutinin (HA) mRNA, partial cds564 bp linear mRNAAF362782.1 GI:14571933Influenza A virus (A / Taiwan / 0132 / 96 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303708.1 GI:32330905Influenza A virus (A / human / Taiwan / 0211 / 96(H1N1)) hemagglutinin (HA) mRNA, partial cds564 bp linear mRNAAF362783.1 GI:14571935Influenza A virus (A / Taiwan / 0211 / 96 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303709.1 GI:32330907Influenza A virus (A / human / Taiwan / 0235 / 96(H1N1)) hemagglutinin (HA) mRNA, partial cds564 bp linear mRNAAF362784.1 GI:14571937Influenza A virus (A / Taiwan / 0235 / 96 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303710.1 GI:32330909Influenza A virus (A / human / Taiwan / 0255 / 96(H1N1)) hemagglutinin (HA) mRNA, partial cds564 bp linear mRNAAF362785.1 GI:14571939Influenza A virus (A / Taiwan / 0255 / 96 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303711.1 GI:32330911Influenza A virus (A / human / Taiwan / 0337 / 96(H1N1)) hemagglutinin (HA) mRNA, partial cds564 bp linear mRNAAF362786.1 GI:14571941Influenza A virus (A / human / Taiwan / 0342 / 96(H1N1)) hemagglutinin (HA) mRNA, partial cds564 bp linear mRNAAF362787.1 GI:14571943Influenza A virus (A / Taiwan / 0342 / 96 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303714.1 GI:32330917Influenza A virus (A / human / Taiwan / 0464 / 99(H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAF362788.1 GI:14571945Influenza A virus (A / human / Iaiwan / 0562 / 95(H1N1)) hemagglutinin (HA) mRNA, partial cds564 bp linear mRNAAF362789.1 GI:14571947Influenza A virus (A / Taiwan / 0562 / 95 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303720.1 GI: 32330929Influenza A virus (A / human / Taiwan / 0563 / 95(H1N1)) hemagglutinin (HA) mRNA, partial cds564 bp linear mRNAAF362790.1 GI:14571949Influenza A virus (A / Taiwan / 0563 / 95 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303721.1 GI:32330931Influenza A virus (A / human / Taiwan / 0657 / 95(H1N1)) hemagglutinin (HA) mRNA, partial cds564 bp linear mRNAAF362791.1 GI:14571951Influenza A virus (A / Taiwan / 0657 / 95 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303724.1 GI:32330937Influenza A virus (A / Taiwan / 0859 / 2002(H1N1)) hemagglutinin mRNA, partial cds494 bp linear mRNAAY604801.1 GI:50727482Influenza A virus (A / human / Taiwan / 0892 / 99(H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAF362792.1 GI:14571953Influenza A virus (A / Taiwan / 0983 / 2002(H1N1)) hemagglutinin mRNA, partial cds494 bp linear mRNAAY604800.1 GI:50727480Influenza A virus (A / Taiwan / 1007 / 2006(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068163.1 GI:158452199Influenza A virus (A / Taiwan / 1015 / 2006(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068171.1 GI:158452215Influenza A virus (A / Taiwan / 112 / 1996-1(H1N1)) haemagglutinin (HA) mRNA, partial cds1,176 bp linear mRNAAF026153.1 GI:2554950Influenza A virus (A / Taiwan / 112 / 1996-2(H1N1)) haemagglutinin (HA) mRNA, partial cds1,176 bp linear mRNAAF026154.1 GI:2554952Influenza A virus (A / Taiwan / 117 / 1996-1(H1N1)) haemagglutinin (HA) mRNA, partial cds1,176 bp linear mRNAAF026155.1 GI:2554954Influenza A virus (A / Taiwan / 117 / 1996-2(H1N1)) haemagglutinin (HA) mRNA, partial cds1,176 bp linear mRNAAF026156.1 GI:2554956Influenza A virus (A / Taiwan / 117 / 1996-3(H1N1)) haemagglutinin (HA) mRNA, partial cds1,176 bp linear mRNAAF026157.1 GI:2554958Influenza A virus (A / Taiwan / 118 / 1996-1(H1N1)) haemagglutinin (HA) mRNA, partial cds1,176 bp linear mRNAAF026158.1 GI:2554960Influenza A virus (A / Taiwan / 118 / 1996-2(H1N1)) haemagglutinin (HA) mRNA, partial cds1,176 bp linear mRNAAF026159.1 GI:2554962Influenza A virus (A / Taiwan / 118 / 1996-3(H1N1)) haemagglutinin (HA) mRNA, partial cds1,176 bp linear mRNAAF026160.1 GI:2554964Influenza A virus (A / human / Taiwan / 1184 / 99(H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAF362793.1 GI:14571955Influenza A virus (A / Taiwan / 1184 / 99 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303726.1 GI:32330941Influenza A virus (A / human / Taiwan / 1190 / 95(H1N1)) hemagglutinin (HA) mRNA, partial cds564 bp linear mRNAAF362794.1 GI:14571957Influenza A virus (A / Taiwan / 1190 / 95 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303727.1 GI:32330943Influenza A virus (A / Taiwan / 1523 / 2003(H1N1)) hemagglutinin mRNA, partial cds494 bp linear mRNAAY604808.1 GI:50727496Influenza A virus (A / Taiwan / 1566 / 2003(H1N1)) hemagglutinin mRNA, partial cds494 bp linear mRNAAY604806.1 GI:50727492Influenza A virus (A / Taiwan / 1769 / 96(H1N1)) matrix protein M1 (M) mRNA, partial cds875 bp linear mRNAAF138710.2 GI:4996871Influenza A virus (A / Taiwan / 1906 / 2002(H1N1)) hemagglutinin mRNA, partial cds494 bp linear mRNAAY604799.1 GI:50727478Influenza A virus (A / Taiwan / 1922 / 2002(H1N1)) hemagglutinin mRNA, partial cds494 bp linear mRNAAY604802.1 GI:50727484Influenza A virus (A / Taiwan / 2069 / 2006(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068168.1 GI:158452209Influenza A virus (A / Taiwan / 2157 / 2001 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303733.1 GI:32330955Influenza A virus (A / Taiwan / 2175 / 2001 (H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAY303734.1 GI:32330957Influenza A virus (A / human / Iaiwan / 2200 / 95(H1N1)) hemagglutinin (HA) mRNA, partial cds564 bp linear mRNAAF362795.1 GI:14571959Influenza A virus (A / Taiwan / 2200 / 95 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303737.1 GI:32330963Influenza A virus (A / Taiwan / 2966 / 2006(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068170.1 GI:158452213Influenza A virus (A / Taiwan / 3168 / 2005(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068174.1 GI:158452221Influenza A virus (A / human / Taiwan / 3355 / 97(H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAF362796.1 GI:14571961Influenza A virus (A / Taiwan / 3355 / 97 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303739.1 GI:32330967Influenza A virus (A / Taiwan / 3361 / 2001 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303740.1 GI:32330969Influenza A virus (A / Taiwan / 3361 / 2001 (H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAY303741.1 GI:32330971Influenza A virus (A / Taiwan / 3518 / 2006(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068169.1 GI:158452211Influenza A virus (A / human / Taiwan / 3825 / 00(H1N1)) hemagglutinin (HA) mRNA, partial cds581 bp linear mRNAAF362797.1 GI:14571963Influenza A virus (A / Taiwan / 3896 / 2001 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303746.1 GI:32330981Influenza A virus (A / Taiwan / 3896 / 2001 (H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAY303747.1 GI:32330983Influenza A virus (A / Taiwan / 4050 / 2003(H1N1)) hemagglutinin mRNA, partial cds494 bp linear mRNAAY604807.1 GI:50727494Influenza A virus (A / Taiwan / 4054 / 2006(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068160.1 GI:158452193Influenza A virus (A / human / Taiwan / 4360 / 99(H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAF362798.1 GI:14571965Influenza A virus (A / Taiwan / 4360 / 99 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303748.1 GI:32330985Influenza A virus (A / human / Taiwan / 4415 / 99(H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAF362799.1 GI:14571967Influenza A virus (A / Taiwan / 4415 / 99 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303749.1 GI:32330987Influenza A virus (A / Taiwan / 4509 / 2006(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068165.1 GI:158452203Influenza A virus (A / human / Taiwan / 4845 / 99(H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAF362800.1 GI:14571969Influenza A virus (A / Taiwan / 4845 / 99 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303750.1 GI:32330989Influenza A virus (A / human / Taiwan / 4943 / 99(H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAF362801.1 GI:14571971Influenza A virus (A / Taiwan / 5010 / 2006(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068167.1 GI:158452207Influenza A virus (A / human / Taiwan / 5063 / 99(H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAF362802.1 GI:14571973Influenza A virus (A / Taiwan / 5063 / 99 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303751.1 GI:32330991Influenza A virus (A / Taiwan / 5084 / 2006(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068166.1 GI:158452205Influenza A virus (A / Taiwan / 511 / 96(H1N1)) matrix protein M1 (M) mRNA, partial cds875 bp linear mRNAAF138708.2 GI:4996867Influenza A virus (A / Taiwan / 557 / 2006(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068156.1 GI:158452185Influenza A virus (A / Taiwan / 562 / 2006(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068159.1 GI:158452191Influenza A virus (A / human / Taiwan / 5779 / 98(H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAF362778.1 GI:14571925Influenza A virus (A / Taiwan / 5779 / 98 (H1N1)) polymerase basic protein 1 (PB1) mRNA, partial cds303 bp linear mRNAAY303702.1 GI:32330893Influenza A virus (A / Taiwan / 6025 / 2005(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068172.1 GI:158452217Influenza A virus (A / Taiwan / 607 / 2006(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068157.1 GI:158452187Influenza A virus (A / Taiwan / 615 / 2006(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068162.1 GI:158452197Influenza A virus (A / Taiwan / 645 / 2006(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068164.1 GI:158452201Influenza A virus (A / Taiwan / 680 / 2005(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068173.1 GI:158452219Influenza A virus (A / Taiwan / 719 / 2006(H1N1)) hemagglutinin (HA) mRNA, partial cds507 bp linear mRNAEU068158.1 GI:158452189Influenza A virus (A / Thailand / CU124 / 2006(H3N2)) neuraminidase (NA) mRNA, complete cds1,410 bp linear mRNAEU021285.1 GI:154224724Influenza A virus (A / Thailand / CU32 / 2006(H1N1)) neuraminidase (NA) mRNA, complete cds1,413 bp linear mRNAEU021265.1 GI:154224704Influenza A virus (A / Thailand / CU32 / 2006(H1N1)) hemagglutinin (HA) mRNA, complete cds1,698 bp linear mRNAEU021264.1 GI:154224775Influenza A virus (A / Thailand / CU41 / 2006(H1N1)) neuraminidase (NA) mRNA, complete cds1,413 bp linear mRNAEU021247.1 GI:154224686Influenza A virus (A / Thailand / CU41 / 2006(H1N1)) hemagglutinin (HA) mRNA, complete cds1,698 bp linear mRNAEU021246.1 GI:154224757Influenza A virus (A / Thailand / CU44 / 2006(H1N1)) neuraminidase (NA) mRNA, complete cds1,413 bp linear mRNAEU021259.1 GI:154224698Influenza A virus (A / Thailand / CU44 / 2006(H1N1)) hemagglutinin (HA) mRNA, complete cds1,698 bp linear mRNAEU021258.1 GI:154224769Influenza A virus (A / Thailand / CU51 / 2006(H1N1)) neuraminidase (NA) mRNA, complete cds1,413 bp linear mRNAEU021255.1 GI:154224694Influenza A virus (A / Thailand / CU51 / 2006(H1N1)) hemagglutinin (HA) mRNA, complete cds1,698 bp linear mRNAEU021254.1 GI:154224765Influenza A virus (A / Thailand / CU53 / 2006(H1N1)) neuraminidase (NA) mRNA, complete cds1,413 bp linear mRNAEU021249.1 GI:154224688Influenza A virus (A / Thailand / CU53 / 2006(H1N1)) hemagglutinin (HA) mRNA, complete cds1,698 bp linear mRNAEU021248.1 GI:154224759Influenza A virus (A / Thailand / CU57 / 2006(H1N1)) neuraminidase (NA) mRNA, complete cds1,413 bp linear mRNAEU021257.1 GI:154224696Influenza A virus (A / Thailand / CU57 / 2006(H1N1)) hemagglutinin (HA) mRNA, complete cds1,698 bp linear mRNAEU021256.1 GI:154224767Influenza A virus (A / Thailand / CU67 / 2006(H1N1)) neuraminidase (NA) mRNA, complete cds1,413 bp linear mRNAEU021251.1 GI:154224690Influenza A virus (A / Thailand / CU67 / 2006(H1N1)) hemagglutinin (HA) mRNA, complete cds1,698 bp linear mRNAEU021250.1 GI:154224761Influenza A virus (A / Thailand / CU68 / 2006(H1N1)) neuraminidase (NA) mRNA, complete cds1,413 bp linear mRNAEU021261.1 GI:154224700Influenza A virus (A / Thailand / CU68 / 2006(H1N1)) hemagglutinin (HA) mRNA, complete cds1,698 bp linear mRNAEU021260.1 GI:154224771Influenza A virus (A / Thailand / CU75 / 2006(H1N1)) neuraminidase (NA) mRNA, complete cds1,413 bp linear mRNAEU021263.1 GI:154224702Influenza A virus (A / Thailand / CU75 / 2006(H1N1)) hemagglutinin (HA) mRNA, complete cds1,698 bp linear mRNAEU021262.1 GI:154224773Influenza A virus (A / Thailand / CU88 / 2006(H1N1)) neuraminidase (NA) mRNA, complete cds1,413 bp linear mRNAEU021253.1 GI:154224692Influenza A virus (A / Thailand / CU88 / 2006(H1N1)) hemagglutinin (HA) mRNA, complete cds1,698 bp linear mRNAEU021252.1 GI:154224763Influenza A virus (A / turkey / England / 647 / 1977(H1N1)) nucleoprotein mRNA, complete cds1,565 bp linear mRNAM76603.1 GI:325094Influenza A virus (A / turkey / France / 87075 / 87(H1N1)) N1 gene for neuraminidase, genomic RNA1,445 bp linear mRNAAJ416626.1 GI:39840719Influenza A virus (A / turkey / Germany / 3 / 91(H1N1)) mRNA for PB2 polymerase (partial)394 bp linear mRNAZ30272.1 GI:456652Influenza A virus (A / turkey / Germany / 3 / 91(H1N1)) mRNA for neuraminidase (UTR)97 bp linear mRNAZ30275.1 GI:530398Influenza A virus (A / turkey / Germany / 3 / 91(H1N1)) mRNA for PA polymerase264 bp linear mRNAZ30274.1 GI:530401Influenza A virus (A / turkey / Germany / 3 / 91(H1N1)) mRNA for PBI polymerase (partial)247 bp linear mRNAZ30273.1 GI:530403Influenza A virus (A / turkey / Germany / 3 / 91(H1N1)) mRNA for hemagglutinin HA11,038 bp linear mRNAZ46441.1 GI:854218Influenza A virus (A / turkey / Minnesota / 1661 / 1981(H1N1)) hemagglutinin (HA) mRNA, partial cds981 bp linear mRNAU46941.1 GI:1912332Influenza A virus (A / turkey / Minnesota / 1661 / 81(H1N1)) segment 4 hemagglutinin precursor (HA) mRNA, complete cds1,777 bp linear mRNAAF091310.1 GI:4585162Influenza A virus (A / turkey / North Carolina / 1790 / 1988(H1N1)) nucleoprotein mRNA, complete cds1,565 bp linear mRNAM76609.1 GI:325096Influenza A virus (A / Weiss / 43 (H1N1)) neuraminidase (NA) gene, complete cds1,410 bp linear mRNAAF250365.2 GI:13260589Influenza A virus (A / Wilson-Smith / 1933(H1N1)) nucleocapsid protein (NP) mRNA, complete cds1,497 bp linear mRNAEU330203.1 GI:167989512Influenza A virus (A / Wisconsin / 3523 / 1988(H1N1)) neuraminidase (NA) mRNA, partial cds241 bp linear mRNAU47816.1 GI:1912352Influenza A virus (A / Wisconsin / 3623 / 1988(H1N1)) nucleoprotein mRNA, complete cds1,565 bp linear mRNAM76610.1 GI:325103Influenza A virus (A / WI / 4754 / 1994(H1N1)) PB1 (PB1) mRNA, partial cds235 bp linear mRNAU53156.1 GI:1399590Influenza A virus (A / WI / 4754 / 1994(H1N1)) PB2 (PB2) mRNA, partial cds168 bp linear mRNAU53158.1 GI:1399594Influenza A virus (A / WI / 4754 / 1994(H1N1)) PA (PA) mRNA, partial cds621 bp linear mRNAU53160.1 GI:1399598Influenza A virus (A / WI / 4754 / 1994(H1N1)) hemagglutinin (HA) mRNA, complete cds1,778 bp linear mRNAU53162.1 GI:1399602Influenza A virus (A / WI / 4754 / 1994(H1N1)) NP (NP) mRNA, partial cds200 bp linear mRNAU53164.1 GI:1399606Influenza A virus (A / WI / 4754 / 1994(H1N1)) neuraminidase (NA) mRNA, complete cds1,458 bp linear mRNAU53166.1 GI:1399610Influenza A virus (A / WI / 4754 / 1994(H1N1)) M (M) mRNA, complete cds1,027 bp linear mRNAU53168.1 GI:1399614Influenza A virus (A / WI / 4754 / 1994(H1N1)) NS (NS) mRNA, complete cds890 bp linear mRNAU53170.1 GI:1399618Influenza A virus (A / WI / 4755 / 1994(H1N1)) PB1 (PB1) mRNA, partial cds203 bp linear mRNAU53157.1 GI:1399592Influenza A virus (A / WI / 4755 / 1994(H1N1)) PB2 (PB2) mRNA, partial cds173 bp linear mRNAU53159.1 GI:1399596Influenza A virus (A / WI / 4755 / 1994(H1N1)) PA (PA) mRNA, partial cds621 bp linear mRNAU53161.1 GI:1399600Influenza A virus (A / WI / 4755 / 1994(H1N1)) hemagglutinin (HA) mRNA, complete cds1,778 bp linear mRNAU53163.1 GI:1399604Influenza A virus (A / WI / 4755 / 1994(H1N1)) NP (NP) mRNA, partial cds215 bp linear mRNAU53165.1 GI:1399608Influenza A virus (A / WI / 4755 / 1994(H1N1)) neuraminidase (NA) mRNA, partial cds209 bp linear mRNAU53167.1 GI:1399612Influenza A virus (A / WI / 4755 / 1994(H1N1)) M (M) mRNA, complete cds1,027 bp linear mRNAU53169.1 GI:1399616Influenza A virus (A / WI / 4755 / 1994(H1N1)) NS (NS) mRNA, complete cds890 bp linear mRNAU53171.1 GI:1399620Influenza A virus (A / WSN / 33) segment 5 nucleocapsid protein (NP) mRNA, partial cds543 bp linear mRNAAF306656.1 GI:11935089 Table 7. Influenza H3N2 Antigens Strain / Protein Length GenBank / GI Accession No. 1. Influenza A virus (A / Aichi / 2 / 1968(H3N2)) hemagglutinin (HA) mRNA, complete cds1,704 bp linear mRNAEF614248.1 GI:1489108192. Influenza A virus (A / Aichi / 2 / 1968(H3N2)) hemagglutinin (HA) mRNA, partial cds1,698 bp linear mRNAEF614249.1 GI:1489108213. Influenza A virus (A / Aichi / 2 / 1968(H3N2)) hemagglutinin (HA) mRNA, partial cds1,698 bp linear mRNAEF614250.1 GI:1489108234. Influenza A virus (A / Aichi / 2 / 1968(H3N2)) hemagglutinin (HA) mRNA, partial cds1,698 bp linear mRNAEF614251.1 GI:1489108255. Influenza A virus (A / Akita / 1 / 1995(H3N2)) haemagglutinin mRNA, partial cds1,032 bp linear mRNAU48444.1 GI:15749896. Influenza A virus (A / Beijing / 32 / 1992(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46392.1 GI:6090207. Influenza A virus (A / Canada / 33312 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501516.1 GI:213142888. Influenza A virus (A / Charlottesville / 10 / 99 (H3N2)) hemagglutinin mRNA, partial cds987 bp linear mRNAAF297094.1 GI:112289179. Influenza A virus (A / Charlottesville / 49 / 99 (H3N2)) hemagglutinin mRNA, partial cds987 bp linear mRNAAF297096.1 GI:1122892110. Influenza A virus (A / Charlottesville / 69 / 99 (H3N2)) hemagglutinin mRNA, partial cds987 bp linear mRNAAF297097.1 GI:1122892311. Influenza A virus (A / Charlottesville / 73 / 99 (H3N2)) hemagglutinin mRNA, partial cds987 bp linear mRNAAF297095.1 GI:1122891912. Influenza A virus (A / England / 1 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46393.1 GI:60902413. Influenza A virus (A / England / 247 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46394.1 GI:60902514. Influenza A virus (A / England / 269 / 93(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46395.1 GI:60902715. Influenza A virus (A / England / 284 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46396.1 GI:60902916. Influenza A virus (A / England / 286 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46397.1 GI:60903117. Influenza A virus (A / England / 289 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46398.1 GI:60903318. Influenza A virus (A / England / 328 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46399.1 GI:60903519. Influenza A virus (A / England / 346 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46400.1 GI:60903720. Influenza A virus (A / England / 347 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46401.1 GI:60903921. Influenza A virus (A / England / 42 / 72(H3N2)) hemagglutinin mRNA, partial cds1,091 bp linear mRNAAF201875.1 GI:647027422. Influenza A virus (A / England / 471 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46402.1 GI:60904123. Influenza A virus (A / England / 67 / 1994(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46403.1 GI:60904324. Influenza A virus (A / England / 68 / 1994(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46404.1 GI:60904525. Influenza A virus (A / England / 7 / 1994(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46405.1 GI:60904728. Influenza A virus (A / Guangdong / 25 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46406.1 GI:60904929. Influenza A virus (A / Hong Kong / 1 / 68(H3N2)) hemagglutinin mRNA, partial cds1,091 bp linear mRNAAF201874.1 GI:647027230. Influenza A virus (A / Hong Kong / 1 / 1994(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46407.1 GI:60905131. Influenza A virus (A / Hong Kong / 1143 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382319.1 GI:1448795732. Influenza A virus (A / Hong Kong / 1143 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382320.1 GI:1448795933. Influenza A virus (A / Hong Kong / 1143 / 99(H3N2)) neuraminidase mRNA, complete cds1,466 bp linear mRNAAF382329.1 GI:1448797734. Influenza A virus (A / Hong Kong / 1143 / 99(H3N2)) neuraminidase mRNA, complete cds1,466 bp linear mRNAAF382330.1 GI:1448797935. Influenza A virus (A / Hong Kong / 1144 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAY035589.1 GI:1448640336. Influenza A virus (A / Hong Kong / 1144 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382321.1 GI:1448796137. Influenza A virus (A / Hong Kong / 1144 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382322.1 GI:1448796338. Influenza A virus (A / Hong Kong / 1144 / 99(H3N2)) neuraminidase mRNA, complete cds1,466 bp linear mRNAAF382331.1 GI:1448798139. Influenza A virus (A / Hong Kong / 1144 / 99(H3N2)) neuraminidase mRNA, complete cds1,466 bp linear mRNAAF382332.1 GI:1448798340. Influenza A virus (A / Hong Kong / 1179 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAY035590.1 GI:1448640541. Influenza A virus (A / Hong Kong / 1179 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382323.1 GI:1448796542. Influenza A virus (A / Hong Kong / 1179 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382324.1 GI:1448796743. Influenza A virus (A / Hong Kong / 1180 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAY035591.1 GI:1448640744. Influenza A virus (A / Hong Kong / 1180 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382325.1 GI:1448796945. Influenza A virus (A / Hong Kong / 1180 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382326.1 GI:1448797146. Influenza A virus (A / Hong Kong / 1182 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382327.1 GI:1448797347. Influenza A virus (A / Hong Kong / 1182 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382328.1 GI:1448797548. Influenza A virus (A / Hong Kong / 2 / 1994(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46408.1 GI:60905549. Influenza A virus (A / Hong Kong / 23 / 1992(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46410.1 GI:60905350. Influenza A virus (A / Hong Kong / 34 / 1990(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46409.1 GI:60905751. Influenza A virus (A / England / 286 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46397.1 GI:60903152. Influenza A virus (A / England / 289 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46398.1 GI:60903353. Influenza A virus (A / England / 328 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46399.1 GI:60903554. Influenza A virus (A / England / 346 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46400.1 GI:60903755. Influenza A virus (A / England / 347 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46401.1 GI:60903956. Influenza A virus (A / England / 42 / 72(H3N2)) hemagglutinin mRNA, partial cds1,091 bp linear mRNAAF201875.1 GI:647027457. Influenza A virus (A / England / 471 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46402.1 GI:60904158. Influenza A virus (A / England / 67 / 1994(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46403.1 GI:60904359. Influenza A virus (A / England / 68 / 1994(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46404.1 GI:60904560. Influenza A virus (A / England / 7 / 1994(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46405.1 GI:60904763. Influenza A virus (A / Guandong / 28 / 1994(H3N2)) haemagglutinin mRNA, partial cds1,032 bp linear mRNAU48442.1 GI:157498564. Influenza A virus (A / Guangdong / 25 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46406.1 GI:60904965. Influenza A virus (A / Hebei / 19 / 1995(H3N2)) haemagglutinin mRNA, partial cds1,032 bp linear mRNAU48447.1 GI:157499566. Influenza A virus (A / Hebei / 41 / 1994(H3N2)) haemagglutinin mRNA, partial cds1,032 bp linear mRNAU48441.1 GI:157498367. Influenza A virus (A / Hong Kong / 1 / 68(H3N2)) hemagglutinin mRNA, partial cds1,091 bp linear mRNAAF201874.1 GI:647027268. Influenza A virus (A / Hong Kong / 1 / 1994(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46407.1 GI:60905169. Influenza A virus (A / Hong Kong / 1143 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAY035588.1 GI:1448640170. Influenza A virus (A / Hong Kong / 1143 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382319.1 GI:1448795771. Influenza A virus (A / Hong Kong / 1143 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382320.1 GI:1448795972. Influenza A virus (A / Hong Kong / 1143 / 99(H3N2)) neuraminidase mRNA, complete cds1,466 bp linear mRNAAF382329.1 GI:1448797773. Influenza A virus (A / Hong Kong / 1143 / 99(H3N2)) neuraminidase mRNA, complete cds1,466 bp linear mRNAAF382330.1 GI:1448797974. Influenza A virus (A / Hong Kong / 1144 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAY035589.1 GI:1448640375. Influenza A virus (A / Hong Kong / 1144 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382321.1 GI:1448796176. Influenza A virus (A / Hong Kong / 1144 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382322.1 GI:1448796377. Influenza A virus (A / Hong Kong / 1144 / 99(H3N2)) neuraminidase mRNA, complete cds1,466 bp linear mRNAAF382331.1 GI:1448798178. Influenza A virus (A / Hong Kong / 1144 / 99(H3N2)) neuraminidase mRNA, complete cds1,466 bp linear mRNAAF382332.1 GI:1448798379. Influenza A virus (A / Hong Kong / 1179 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAY035590.1 GI:1448640580. Influenza A virus (A / Hong Kong / 1179 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382323.1 GI:1448796581. Influenza A virus (A / Hong Kong / 1179 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382324.1 GI:1448796782. Influenza A virus (A / Hong Kong / 1180 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAY035591.1 GI:1448640783. Influenza A virus (A / Hong Kong / 1180 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382325.1 GI:1448796984. Influenza A virus (A / Hong Kong / 1180 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382326.1 GI:1448797185. Influenza A virus (A / Hong Kong / 1182 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAY035592.1 GI:1448640986. Influenza A virus (A / Hong Kong / 1182 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382327.1 GI:1448797387. Influenza A virus (A / Hong Kong / 1182 / 99(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382328.1 GI:1448797588. Influenza A virus (A / Hong Kong / 2 / 1994(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46408.1 GI:60905589. Influenza A virus (A / Hong Kong / 23 / 1992(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46410.1 GI:60905390. Influenza A virus (A / Hong Kong / 34 / 1990(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46409.1 GI:60905791. Influenza A virus (A / Indiana / 28170 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501534.1 GI:2131432492. Influenza A virus (A / Kinmen / 618 / 03(H3N2)) hemagglutinin (HA) mRNA, partial cds529 bp linear mRNAAY961997.1 GI:6813815193. Influenza A virus (A / Kinmen / 618 / 03(H3N2)) neuraminidase (NA) mRNA, partial cds383 bp linear mRNAAY973325.1 GI:7067320694. Influenza A virus (A / Kinmen / 618 / 03(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY986986.1 GI:7072809995. Influenza A virus (A / Kinmen / 621 / 03(H3N2)) hemagglutinin (HA) mRNA, partial cds545 bp linear mRNAAY962017.1 GI:6813819196. Influenza A virus (A / Kinmen / 621 / 03(H3N2)) neuraminidase (NA) mRNA, partial cds386 bp linear mRNAAY973326.1 GI:7067320897. Influenza A virus (A / Kinmen / 621 / 03(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY986987.1 GI:7072810198. Influenza A virus (A / Kinmen / 639 / 04(H3N2)) hemagglutinin (HA) mRNA, partial cds786 bp linear mRNAAY962008.1 GI:6813817399. Influenza A virus (A / Kinmen / 639 / 04(H3N2)) neuraminidase (NA) mRNA, partial cds381 bp linear mRNAAY973327.1 GI:70673210100. Influenza A virus (A / Kinmen / 639 / 04(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY986988.1 GI:70728103101. Influenza A virus (A / Kinmen / 641 / 04(H3N2)) hemagglutinin (HA) mRNA, partial cds596 bp linear mRNAAY962004.1 GI:68138165102. Influenza A virus (A / Kinmen / 641 / 04(H3N2)) neuraminidase (NA) mRNA, partial cds785 bp linear mRNAAY973328.1 GI:70673212103. Influenza A virus (A / Kinmen / 642 / 04(H3N2)) hemagglutinin (HA) mRNA, partial cds576 bp linear mRNAAY962001.1 GI:68138159104. Influenza A virus (A / Kinmen / 642 / 04(H3N2)) neuraminidase (NA) mRNA, partial cds580 bp linear mRNAAY973329.1 GI:70673214105. Influenza A virus (A / Kinmen / 642 / 04(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY986989.1 GI:70728105106. Influenza A virus (A / Kinmen / 645 / 04(H3N2)) hemagglutinin (HA) mRNA, partial cds789 bp linear mRNAAY962009.1 GI:68138175107. Influenza A virus (A / Kinmen / 645 / 04(H3N2)) neuraminidase (NA) mRNA, partial cds581 bp linear mRNAAY973330.1 GI:70673216108. Influenza A virus (A / Kinmen / 645 / 04(H3N2)) nucleoprotein (NP) mRNA, partial cds981 bp linear mRNAAY986990.1 GI:70728107109. Influenza A virus (A / LosAngeles / 2 / 1987(H3N2)) polymerase protein basic 2 (PB2) mRNA, complete cds2,341 bp linear mRNAU62543.1 GI:1480737110. Influenza A virus (A / Madrid / 252 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46411.1 GI:609067111. Influenza A virus (A / Michigan / 22568 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501531.1 GI:21314318112. Influenza A virus (A / Michigan / 22692 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501518.1 GI:21314292113. Influenza A virus (A / Moscow / 10 / 99(H3N2)) partial NS1 gene for non structural protein 1 and partial NS2 gene for non structural protein 2, genomic RNA754 bp linear mRNAAJ519454.1 GI:31096423114. Influenza A virus (A / ningbo / 17 / 2002(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAY138518.1 GI:24895178115. Influenza A virus (A / ningbo / 25 / 2002(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAY138517.1 GI:24895169116. Influenza A virus (A / NT / 60 / 68 / 29C(H3N2)) mRNA for haemagglutinin (HA1 and HA2 genes)1,765 bp linear mRNAV01103.1 GI:60800117. Influenza A virus (A / Oklahoma / 323 / 03(H3N2)) hemagglutinin mRNA, complete cds1,701 bp linear mRNADQ059385.1 GI:66933143118. Influenza A virus (A / Oklahoma / 323 / 03(H3N2)) neuraminidase mRNA, complete cds1,410 bp linear mRNADQ059384.2 GI:75859981119. Influenza A virus (A / Panama / 2007 / 99(H3N2)) partial NS1 gene for non structural protein 1 and partial NS2 gene for non structural protein 2, genomic RNA766 bp linear mRNAAJ519458.1 GI:31096435120. Influenza A virus (A / Pennsalvanya / 20109 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501526.1 GI:21314308121. Influenza A virus (A / Philippines / 2 / 82(H3N2)) hemagglutinin mRNA, partial cds1,091 bp linear mRNAAF233691.1 GI:7331124122. Influenza A virus (A / Pingtung / 303 / 04(H3N2)) hemagglutinin (HA) mRNA, partial cds767 bp linear mRNAAY962000.1 GI:68138157123. Influenza A virus (A / Pingtung / 303 / 04(H3N2)) neuraminidase (NA) mRNA, partial cds783 bp linear mRNAAY973331.1 GI:70673218124. Influenza A virus (A / Pingtung / 303 / 04(H3N2)) nucleoprotein (NP) mRNA, partial cds928 bp linear mRNAAY986991.1 GI:70728109125. Influenza A virus (A / Pingtung / 313 / 04(H3N2)) hemagglutinin (HA) mRNA, partial cds788 bp linear mRNAAY961999.1 GI:68138155126. Influenza A virus (A / Pingtung / 313 / 04(H3N2)) neuraminidase (NA) mRNA, partial cds787 bp linear mRNAAY973332.1 GI:70673220127. Influenza A virus (A / Pingtung / 313 / 04(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY986992.1 GI:70728111128. Influenza A virus (A / ruddy turnstone / Delaware / 142 / 99 (H3N2)) nonfunctional matrix protein mRNA, partial sequence927 bp linear mRNAAY664458.1 GI:51011862129. Influenza A virus (A / Scotland / 142 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46413.1 GI:609059130. Influenza A virus (A / Scotland / 160 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46414.1 GI:609061131. Influenza A virus (A / Scotland / 173 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46416.1 GI:609063132. Influenza A virus (A / Scotland / 174 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46415.1 GI:609065133. Influenza A virus (A / Scotland / 2 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46412.1 GI:609069134. Influenza A virus (A / Sendai / cl82 / 1994(H3N2)) haemagglutinin mRNA, partial cds1,032 bp linear mRNAU48439.1 GI:1574979135. Influenza A virus (A / Sendai / c373 / 1995(H3N2)) haemagglutinin mRNA, partial cds1,032 bp linear mRNAU48445.1 GI:1574991136. Influenza A virus (A / Sendai / c384 / 1994(H3N2)) haemagglutinin mRNA, partial cds1,032 bp linear mRNAU48440.1 GI:1574981137. Influenza A virus (A / Shangdong / 9 / 1993(H3N2)) mRNA for haemagglutinin1,041 bp linear mRNAZ46417.1 GI:609071138. Influenza A virus (A / Shanghai / 11 / 1987 / X99aE high yield reassortant(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAL19416.1 GI:348117139. Influenza A virus (A / sw / Shizuoka / 110 / 97(H3N2)) polymerase basic 2 (PB2) mRNA, complete cds2,280 bp linear mRNAAF225514.1 GI:27462098140. Influenza A virus (A / sw / Shizuoka / 110 / 97(H3N2)) polymerase basic 1 (PB1) mRNA, complete cds2,274 bp linear mRNAAF225518.1 GI:27462106141. Influenza A virus (A / sw / Shizuoka / 110 / 97(H3N2)) polymerase acidic (PA) mRNA, complete cds2,151 bp linear mRNAAF225522.1 GI:27462114142. Influenza A virus (A / sw / Shizuoka / 110 / 97(H3N2)) nucleoprotein (NP) mRNA, complete cds1,497 bp linear mRNAAF225534.1 GI:27462146143. Influenza A virus (A / sw / Shizuoka / 110 / 97(H3N2)) neuraminidase (NA) mRNA, complete cds1,410 bp linear mRNAAF225538.1 GI:27462154144. Influenza A virus (A / sw / Shizuoka / 110 / 97(H3N2)) hemagglutinin (HA1) mRNA, partial cds984 bp linear mRNAAF225542.1 GI:27462162145. Influenza A virus (A / sw / Shizuoka / 115 / 97(H3N2)) polymerase basic 2 (PB2) mRNA, complete cds2,280 bp linear mRNAAF225515.1 GI:27462100146. Influenza A virus (A / sw / Shizuoka / 115 / 97(H3N2)) polymerase basic 1 (PB1) mRNA, complete cds2,274 bp linear mRNAAF225519.1 GI:27462108147. Influenza A virus (A / sw / Shizuoka / 115 / 97(H3N2)) polymerase acidic (PA) mRNA, complete cds2,151 bp linear mRNAAF225523.1 GI:27462116148. Influenza A virus (A / sw / Shizuoka / 115 / 97(H3N2)) nucleoprotein (NP) mRNA, complete cds1,497 bp linear mRNAAF225535.1 GI:27462148149. Influenza A virus (A / sw / Shizuoka / 115 / 97(H3N2)) neuraminidase (NA) mRNA, complete cds1,410 bp linear mRNAAF225539.1 GI:27462156150. Influenza A virus (A / sw / Shizuoka / 115 / 97(H3N2)) hemagglutinin (HA1) mRNA, partial cds984 bp linear mRNAAF225543.1 GI:27462164151. Influenza A virus (A / sw / Shizuoka / 119 / 97(H3N2)) polymerase basic 2 (PB2) mRNA, complete cds2,280 bp linear mRNAAF225516.1 GI:27462102152. Influenza A virus (A / sw / Shizuoka / 119 / 97(H3N2)) polymerase basic 1 (PB1) mRNA, complete cds2,274 bp linear mRNAAF225520.1 GI:27462110153. Influenza A virus (A / sw / Shizuoka / 119 / 97(H3N2)) polymerase acidic (PA) mRNA, complete cds2,151 bp linear mRNAAF225524.1 GI:27462118154. Influenza A virus (A / sw / Shizuoka / 119 / 97(H3N2)) nucleoprotein (NP) mRNA, complete cds1,497 bp linear mRNAAF225536.1 GI:27462150155. Influenza A virus (A / sw / Shizuoka / 119 / 97(H3N2)) neuraminidase (NA) mRNA, complete cds1,410 bp linear mRNAAF225540.1 GI:27462158156. Influenza A virus (A / sw / Shizuoka / 119 / 97(H3N2)) hemagglutinin (HA1) mRNA, partial cds984 bp linear mRNAAF225544.1 GI:27462166159. Influenza A virus (A / swine / Bakum / IDT1769 / 2003(H3N2)) neuraminidase mRNA, complete cds1,410 bp linear mRNAEU163948.1 GI:157679552163. Influenza A virus (A / swine / Fujian / 668 / 01(H3N2)) nonfunctional hemagglutinin mRNA, complete sequence1,738 bp linear mRNAAY857957.1 GI:58042507164. Influenza A virus PB2 gene for Polymerase 2 protein, genomic RNA, strain A / Swine / Italy / 1523 / 982,280 bp linear mRNAAJ311459.1 GI:13661041165. Influenza A virus PB1 gene for Polymerase 1 protein, genomic RNA, strain A / Swine / Italy / 1523 / 982,274 bp linear mRNAAJ311460.1 GI:13661043166. Influenza A virus (A / swine / Italy / 1523 / 98(H3N2)) NS1 gene for non structural protein 1 and NS2 gene for non structural protein 2, genomic RNA821 bp linear mRNAAJ344024.1 GI:20068146167. Influenza A virus (A / swine / Re220 / 92hp(H3N2)) neuraminidase mRNA, complete cds1,465 bp linear mRNAEU163949.1 GI:157679554168. Influenza A virus (A / sw / Shizuoka / 120 / 97(H3N2)) polymerase basic 2 (PB2) mRNA, complete cds2,280 bp linear mRNAAF225517.1 GI:27462104169. Influenza A virus (A / sw / Shizuoka / 120 / 97(H3N2)) polymerase basic 1 (PB1) mRNA, complete cds2,274 bp linear mRNAAF225521.1 GI:27462112170. Influenza A virus (A / sw / Shizuoka / 120 / 97(H3N2)) polymerase acidic (PA) mRNA, complete cds2,151 bp linear mRNAAF225525.1 GI:27462120171. Influenza A virus (A / sw / Shizuoka / 120 / 97(H3N2)) nucleoprotein (NP) mRNA, complete cds1,497 bp linear mRNAAF225537.1 GI:27462152172. Influenza A virus (A / sw / Shizuoka / 120 / 97(H3N2)) neuraminidase (NA) mRNA, complete cds1,410 bp linear mRNAAF225541.1 GI:27462160173. Influenza A virus (A / sw / Shizuoka / 120 / 97(H3N2)) hemagglutinin (HA1) mRNA, partial cds984 bp linear mRNAAF225545.1 GI:27462168174. Influenza A virus (A / Switzerland / 7729 / 98(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAY032978.1 GI:14161723175. Influenza A virus (A / Switzerland / 7729 / 98(H3N2)) hemagglutinin mRNA, complete cds1,762 bp linear mRNAAF382318.1 GI:14487955176. Influenza A virus (A / Tainan / 704 / 03(H3N2)) hemagglutinin (HA) mRNA, partial cds528 bp linear mRNAAY962011.1 GI:68138179177. Influenza A virus (A / Tainan / 704 / 03(H3N2)) neuraminidase (NA) mRNA, partial cds384 bp linear mRNAAY973333.1 GI:70673222178. Influenza A virus (A / Tainan / 704 / 03(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY986993.1 GI:70728113179. Influenza A virus (A / Tainan / 712 / 03(H3N2)) hemagglutinin (HA) mRNA, partial cds519 bp linear mRNAAY962012.1 GI:68138181180. Influenza A virus (A / Tainan / 712 / 03(H3N2)) neuraminidase (NA) mRNA, partial cds383 bp linear mRNAAY973334.1 GI:70673224181. Influenza A virus (A / Tainan / 712 / 03(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY986994.1 GI:70728115182. Influenza A virus (A / Tainan / 722 / 03(H3N2)) hemagglutinin (HA) mRNA, partial cds784 bp linear mRNAAY962005.1 GI:68138167183. Influenza A virus (A / Tainan / 722 / 03(H3N2)) neuraminidase (NA) mRNA, partial cds592 bp linear mRNAAY973335.1 GI:70673226184. Influenza A virus (A / Tainan / 722 / 03(H3N2)) nucleoprotein (NP) mRNA, partial cds936 bp linear mRNAAY986995.1 GI:70728117185. Influenza A virus (A / Taipei / 407 / 03(H3N2)) hemagglutinin (HA) mRNA, partial cds788 bp linear mRNAAY961998.1 GI:68138153186. Influenza A virus (A / Taipei / 407 / 03(H3N2)) neuraminidase (NA) mRNA, partial cds787 bp linear mRNAAY973336.1 GI:70673228187. Influenza A virus (A / Taipei / 407 / 03(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY986996.1 GI:70728119188. Influenza A virus (A / Taipei / 416 / 03(H3N2)) hemagglutinin (HA) mRNA, partial cds787 bp linear mRNAAY962007.1 GI:68138171189. Influenza A virus (A / Taipei / 416 / 03(H3N2)) neuraminidase (NA) mRNA, partial cds782 bp linear mRNAAY973337.1 GI:70673230190. Influenza A virus (A / Taipei / 416 / 03(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY986997.1 GI:70728121191. Influenza A virus (A / Taiwan / 0020 / 98 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303703.1 GI:32330895192. Influenza A virus (A / Taiwan / 0040 / 2003(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604817.1 GI:50727514193. Influenza A virus (A / Taiwan / 0045 / 98 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303705.1 GI:32330899194. Influenza A virus (A / human / Taiwan / 0095 / 96(H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAF362820.1 GI:15055140195. Influenza A virus (A / Taiwan / 0097 / 2003(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604828.1 GI:50727536196. Influenza A virus (A / Taiwan / 0104 / 2001 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303706.1 GI:32330901197. Influenza A virus (A / human / Taiwan / 0118 / 98(H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAF362805.1 GI:15055110198. Influenza A virus (A / Taiwan / 0122 / 2003(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604823.1 GI:50727526199. Influenza A virus (A / human / Taiwan / 0149 / 00(H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAF362806.1 GI:15055112200. Influenza A virus (A / Taiwan / 0275 / 2000 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303712.1 GI:32330913201. Influenza A virus (A / Taiwan / 0275 / 2000 (H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAY303713.1 GI:32330915202. Influenza A virus (A / human / Taiwan / 0293 / 98(H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAF362807.1 GI:15055114203. Influenza A virus (A / Taiwan / 0346 / 98 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303715.1 GI:32330919204. Influenza A virus (A / Taiwan / 0379 / 2000 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303716.1 GI:32330921205. Influenza A virus (A / Taiwan / 0379 / 2000 (H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAY303717.1 GI:32330923206. Influenza A virus (A / Taiwan / 0388 / 2001(H3N2)) hemagglutinin (HA) mRNA, partial cds791 bp linear mRNAAY625729.1 GI:50604415207. Influenza A virus (A / human / Taiwan / 0389 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAF362808.1 GI:15055116208. Influenza A virus (A / human / Taiwan / 0423 / 98(H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAF362809.1 GI:15055118209. Influenza A virus (A / Taiwan / 0423 / 98 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303718.1 GI:32330925210. Influenza A virus (A / human / Taiwan / 0464 / 98(H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAF362810.1 GI:15055120211. Influenza A virus (A / Taiwan / 0464 / 98 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303719.1 GI:32330927212. Influenza A virus (A / Taiwan / 0568 / 2001(H3N2)) hemagglutinin (HA) mRNA, partial cds791 bp linear mRNAAY625730.1 GI:50604440213. Influenza A virus (A / Taiwan / 0570 / 2003(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604822.1 GI:50727524214. Influenza A virus (A / Taiwan / 0572 / 2003(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604827.1 GI:50727534215. Influenza A virus (A / Taiwan / 0578 / 2003(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604821.1 GI:50727522216. Influenza A virus (A / Taiwan / 0583 / 2003(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604820.1 GI:50727520217. Influenza A virus (A / Taiwan / 0646 / 2000 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303722.1 GI:32330933218. Influenza A virus (A / Taiwan / 0646 / 2000 (H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAY303723.1 GI:32330935219. Influenza A virus (A / human / Taiwan / 0830 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAF362811.1 GI:15055122220. Influenza A virus (A / Taiwan / 0964 / 2001(H3N2)) hemagglutinin (HA) mRNA, partial cds791 bp linear mRNAAY625731.1 GI:50604469221. Influenza A virus (A / human / Taiwan / 1008 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAF362812.1 GI:15055124222. Influenza A virus (A / Taiwan / 1008 / 99 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303725.1 GI:32330939223. Influenza A virus (A / Taiwan / 1219 / 2004(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068138.1 GI:158452149224. Influenza A virus (A / Taiwan / 1315 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068125.1 GI:158452123225. Influenza A virus (A / Taiwan / 1511 / 2004(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068153.1 GI:158452179226. Influenza A virus (A / Taiwan / 1533 / 2003(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068119.1 GI:158452111227. Influenza A virus (A / human / Taiwan / 1537 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAF362813.1 GI:15055126228. Influenza A virus (A / Taiwan / 1537 / 99 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303728.1 GI:32330945229. Influenza A virus (A / Taiwan / 1566 / 2003(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604826.1 GI:50727532230. Influenza A virus (A / Taiwan / 1568 / 2003(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604819.1 GI:50727518231. Influenza A virus (A / Taiwan / 158 / 2003(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068116.1 GI:158452105232. Influenza A virus (A / Taiwan / 1600 / 96(H3N2)) matrix protein M1 (M) mRNA, partial cds875 bp linear mRNAAF138709.2 GI:4996869233. Influenza A virus (A / Taiwan / 1613 / 2003(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068117.1 GI:158452107234. Influenza A virus (A / Taiwan / 1651 / 2004(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068148.1 GI:158452169235. Influenza A virus (A / human / Taiwan / 1748 / 97(H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAF362814.1 GI:15055128236. Influenza A virus (A / Taiwan / 1748 / 97 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303729.1 GI:32330947237. Influenza A virus (A / Taiwan / 179 / 96(H3N2)) matrix protein M1 (M) mRNA, partial cds872 bp linear mRNAAF138707.2 GI:4996865238. Influenza A virus (A / Taiwan / 1817 / 2004(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068139.1 GI:158452151239. Influenza A virus (A / Taiwan / 1904 / 2003(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068154.1 GI:158452181240. Influenza A virus (A / Taiwan / 1921 / 2003(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068155.1 GI:158452183241. Influenza A virus (A / human / Taiwan / 1986 / 96(H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAF362815.1 GI:15055130242. Influenza A virus (A / Taiwan / 1990 / 96 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303730.1 GI:32330949243. Influenza A virus (A / Taiwan / 1990 / 96 (H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAY303731.1 GI:32330951244. Influenza A virus (A / Taiwan / 20 / 98(H3N2)) H3 hemagglutinin (HA) mRNA, partial cds861 bp linear mRNAAF139938.1 GI:4972940245. Influenza A virus (A / Taiwan / 20 / 98(H3N2)) N2 neuraminidase (NA) mRNA, partial cds392 bp linear mRNAAF140627.1 GI:4972988246. Influenza A virus (A / Taiwan / 20 / 98(H3N2)) matrix protein M1 (M) mRNA, partial cds875 bp linear mRNAAF138715.2 GI:4996879247. Influenza A virus (A / human / Taiwan / 2031 / 97(H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAF362816.1 GI:15055132248. Influenza A virus (A / Taiwan / 2034 / 96(H3N2)) H3 hemagglutinin (HA) mRNA, partial cds861 bp linear mRNAAF139937.1 GI:4972938249. Influenza A virus (A / Taiwan / 2034 / 96(H3N2)) N2 neuraminidase (NA) mRNA, partial cds392 bp linear mRNAAF140620.1 GI:4972974250. Influenza A virus (A / Taiwan / 2034 / 96(H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303732.1 GI:32330953251. Influenza A virus (A / Taiwan / 2040 / 2003(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604818.1 GI:50727516252. Influenza A virus (A / Taiwan / 2072 / 2006(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068131.1 GI:158452135253. Influenza A virus (A / Taiwan / 21 / 98(H3N2)) H3 hemagglutinin (HA) mRNA, partial cds861 bp linear mRNAAF139934.1 GI:4972932254. Influenza A virus (A / Taiwan / 21 / 98(H3N2)) N2 neuraminidase (NA) mRNA, partial cds392 bp linear mRNAAF140624.1 GI:4972982255. Influenza A virus (A / Taiwan / 21 / 98(H3N2)) matrix protein M1 (M) mRNA, partial cds875 bp linear mRNAAF138716.2 GI:4996881256. Influenza A virus (A / Taiwan / 2191 / 96(H3N2)) H3 hemagglutinin (HA) mRNA, partial cds861 bp linear mRNAAF139932.1 GI:4972928257. Influenza A virus (A / Taiwan / 2191 / 96(H3N2)) N2 neuraminidase (NA) mRNA, partial cds392 bp linear mRNAAF140622.1 GI:4972978258. Influenza A virus (A / Taiwan / 2191 / 96(H3N2)) matrix protein M1 (M) mRNA, partial cds875 bp linear mRNAAF138711.3 GI:156147502259. Influenza A virus (A / Taiwan / 2192 / 96(H3N2)) H3 hemagglutinin (HA) mRNA, partial cds861 bp linear mRNAAF139936.1 GI:4972936260. Influenza A virus (A / Taiwan / 2192 / 96(H3N2)) N2 neuraminidase (NA) mRNA, partial cds392 bp linear mRNAAF140626.1 GI:4972986261. Influenza A virus (A / Taiwan / 2195 / 96 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303735.1 GI:32330959262. Influenza A virus (A / Taiwan / 2195 / 96 (H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAY303736.1 GI:32330961263. Influenza A virus (A / Taiwan / 224 / 98(H3N2)) matrix protein M1 (M) mRNA, partial cds875 bp linear mRNAAF138718.2 GI:4996885264. Influenza A virus (A / human / Taiwan / 2548 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAF362817.1 GI:15055134265. Influenza A virus (A / Taiwan / 268 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068120.1 GI:158452113266. Influenza A virus (A / Taiwan / 3008 / 2004(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068149.1 GI:158452171267. Influenza A virus (A / Taiwan / 3075 / 2003(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068152.1 GI:158452177268. Influenza A virus (A / human / Taiwan / 3083 / 00(H3N2)) hemagglutinin (HA) mRNA, partial cds940 bp linear mRNAAF362818.1 GI:15055136269. Influenza A virus (A / Taiwan / 3131 / 2002(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604811.1 GI:50727502270. Influenza A virus (A / Taiwan / 3154 / 2004(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068145.1 GI:158452163271. Influenza A virus (A / Taiwan / 3187 / 2004(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068141.1 GI:158452155272. Influenza A virus (A / Taiwan / 3245 / 2004(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068134.1 GI:158452141273. Influenza A virus (A / Taiwan / 3294 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068133.1 GI:158452139274. Influenza A virus (A / Taiwan / 3351 / 97(H3N2)) H3 hemagglutinin (HA) mRNA, partial cds861 bp linear mRNAAF139935.1 GI:4972934275. Influenza A virus (A / Taiwan / 3351 / 97(H3N2)) N2 neuraminidase (NA) mRNA, partial cds392 bp linear mRNAAF140625.1 GI:4972984276. Influenza A virus (A / Taiwan / 3351 / 97(H3N2)) matrix protein M1 (M) mRNA, partial cds875 bp linear mRNAAF138713.2 GI:4996875277. Influenza A virus (A / Taiwan / 3351 / 97(H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303738.1 GI:32330965278. Influenza A virus (A / Taiwan / 3387 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068132.1 GI:158452137279. Influenza A virus (A / Taiwan / 3396 / 97 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303742.1 GI:32330973280. Influenza A virus (A / Taiwan / 3396 / 97 (H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAY303743.1 GI:32330975281. Influenza A virus (A / Taiwan / 3427 / 97(H3N2)) H3 hemagglutinin (HA) mRNA, partial cds861 bp linear mRNAAF139930.1 GI:4972924282. Influenza A virus (A / Taiwan / 3427 / 97(H3N2)) N2 neuraminidase (NA) mRNA, partial cds392 bp linear mRNAAF140619.1 GI:4972972283. Influenza A virus (A / Taiwan / 346 / 98(H3N2)) H3 hemagglutinin (HA) mRNA, partial cds861 bp linear mRNAAF139940.1 GI:4972944284. Influenza A virus (A / Taiwan / 346 / 98(H3N2)) N2 neuraminidase (NA) mRNA, partial cds392 bp linear mRNAAF140787.1 GI:4972992285. Influenza A virus (A / Taiwan / 346 / 98(H3N2)) matrix protein M1 (M) mRNA, partial cds875 bp linear mRNAAF138719.2 GI:4996887286. Influenza A virus (A / human / Taiwan / 3460 / 00(H3N2)) truncated hemagglutinin (HA) mRNA, partial cds942 bp linear mRNAAF362819.1 GI:15055138287. Influenza A virus (A / Taiwan / 3469 / 97(H3N2)) H3 hemagglutinin (HA) mRNA, partial cds861 bp linear mRNAAF139933.1 GI:4972930288. Influenza A virus (A / Taiwan / 3469 / 97(H3N2)) N2 neuraminidase (NA) mRNA, partial cds392 bp linear mRNAAF140623.1 GI:4972980289. Influenza A virus (A / Taiwan / 3469 / 97(H3N2)) matrix protein M1 (M) mRNA, partial cds875 bp linear mRNAAF138714.2 GI:4996877290. Influenza A virus (A / Taiwan / 3503 / 97 (H3N2)) polymerase basic protein 1 (PB1) mRNA, partial cds297 bp linear mRNAAY303744.1 GI:32330977291. Influenza A virus (A / Taiwan / 3503 / 97 (H3N2)) hemagglutinin (HA) mRNA, partial cds844 bp linear mRNAAY303745.1 GI:32330979292. Influenza A virus (A / Taiwan / 3513 / 96(H3N2)) matrix protein M1 (M) mRNA, partial cds919 bp linear mRNAAF138712.1 GI:4928900293. Influenza A virus (A / Taiwan / 3513 / 97(H3N2)) H3 hemagglutinin (HA) mRNA, partial cds861 bp linear mRNAAF139931.1 GI:4972926294. Influenza A virus (A / Taiwan / 3513 / 97(H3N2)) N2 neuraminidase (NA) mRNA, partial cds392 bp linear mRNAAF140621.1 GI:4972976295. Influenza A virus (A / Taiwan / 3744 / 2002(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604814.1 GI:50727508296. Influenza A virus (A / human / Taiwan / 3760 / 00(H3N2)) hemagglutinin (HA) mRNA, partial cds940 bp linear mRNAAF362804.1 GI:15055108297. Influenza A virus (A / Taiwan / 3896 / 2001 (H1N1)) hemagglutinin (HA) mRNA, partial cds561 bp linear mRNAAY303747.1 GI:32330983298. Influenza A virus (A / Taiwan / 4050 / 2003(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604825.1 GI:50727530299. Influenza A virus (A / Taiwan / 4063 / 2003(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604824.1 GI:50727528300. Influenza A virus (A / Taiwan / 41 / 2004(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068137.1 GI:158452147301. Influenza A virus (A / Taiwan / 45 / 98(H3N2)) H3 hemagglutinin (HA) mRNA, partial cds861 bp linear mRNAAF139939.1 GI:4972942302. Influenza A virus (A / Taiwan / 45 / 98(H3N2)) N2 neuraminidase (NA) mRNA, partial cds392 bp linear mRNAAF140628.1 GI:4972990303. Influenza A virus (A / Taiwan / 45 / 98(H3N2)) matrix protein M1 (M) mRNA, partial cds875 bp linear mRNAAF138717.2 GI:4996883304. Influenza A virus (A / Taiwan / 4548 / 2003(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068114.1 GI:158452101305. Influenza A virus (A / Taiwan / 4673 / 2002(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604813.1 GI:50727506306. Influenza A virus (A / Taiwan / 4680 / 2002(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604812.1 GI:50727504307. Influenza A virus (A / Taiwan / 4735 / 2004(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068136.1 GI:158452145308. Influenza A virus (A / Taiwan / 4829 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068142.1 GI:158452157309. Influenza A virus (A / Taiwan / 4836 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068130.1 GI:158452133310. Influenza A virus (A / Taiwan / 4865 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068143.1 GI:158452159311. Influenza A virus (A / Taiwan / 4883 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068121.1 GI:158452115312. Influenza A virus (A / Taiwan / 4938 / 2002(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604809.1 GI:50727498313. Influenza A virus (A / Taiwan / 4954 / 2002(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604815.1 GI:50727510314. Influenza A virus (A / Taiwan / 4963 / 2002(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604810.1 GI:50727500315. Influenza A virus (A / Taiwan / 4987 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068122.1 GI:158452117316. Influenza A virus (A / Taiwan / 4990 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068127.1 GI:158452127317. Influenza A virus (A / Taiwan / 5 / 2003(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068118.1 GI:158452109318. Influenza A virus (A / Taiwan / 5153 / 2002(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604816.1 GI:50727512319. Influenza A virus (A / Taiwan / 5267 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068128.1 GI:158452129320. Influenza A virus (A / Taiwan / 556 / 2004(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068146.1 GI:158452165321. Influenza A virus (A / Taiwan / 5694 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068126.1 GI:158452125322. Influenza A virus (A / Taiwan / 587 / 2004(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068147.1 GI:158452167323. Influenza A virus (A / Taiwan / 592 / 2004(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068151.1 GI:158452175324. Influenza A virus (A / Taiwan / 7099 / 2003(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604829.1 GI:50727538325. Influenza A virus (A / Taiwan / 7100 / 2003(H3N2)) hemagglutinin mRNA, partial cds791 bp linear mRNAAY604830.1 GI:50727540326. Influenza A virus (A / Taiwan / 7196 / 2003(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068150.1 GI:158452173327. Influenza A virus (A / Taiwan / 7568 / 2004(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068135.1 GI:158452143328. Influenza A virus (A / Taiwan / 7601 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068144.1 GI:158452161329. Influenza A virus (A / Taiwan / 7681 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068124.1 GI:158452121330. Influenza A virus (A / Taiwan / 7702 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068123.1 GI:158452119331. Influenza A virus (A / Taiwan / 7873 / 2005(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068129.1 GI:158452131332. Influenza A virus (A / Taiwan / 8 / 2003(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068115.1 GI:158452103333. Influenza A virus (A / Taiwan / 93 / 2004(H3N2)) hemagglutinin (HA) mRNA, partial cds750 bp linear mRNAEU068140.1 GI:158452153334. Influenza A virus (A / Taoyuan / 108 / 02(H3N2)) hemagglutinin (HA) mRNA, partial cds528 bp linear mRNAAY962016.1 GI:68138189335. Influenza A virus (A / Taoyuan / 108 / 02(H3N2)) neuraminidase (NA) mRNA, partial cds754 bp linear mRNAAY973338.1 GI:70673232336. Influenza A virus (A / Taoyuan / 108 / 02(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY986998.1 GI:70728123337. Influenza A virus (A / Thailand / CU124 / 2006(H3N2)) neuraminidase (NA) mRNA, complete cds1,410 bp linear mRNAEU021285.1 GI:154224724338. Influenza A virus (A / Thailand / CU124 / 2006(H3N2)) hemagglutinin (HA) mRNA, complete cds1,701 bp linear mRNAEU021284.1 GI:154224795339. Influenza A virus (A / Thailand / CU228 / 2006(H3N2)) neuraminidase (NA) mRNA, complete cds1,410 bp linear mRNAEU021275.1 GI:154224714340. Influenza A virus (A / Thailand / CU228 / 2006(H3N2)) hemagglutinin (HA) mRNA, complete cds1,701 bp linear mRNAEU021274.1 GI:154224785341. Influenza A virus (A / Thailand / CU23 / 2006(H3N2)) neuraminidase (NA) mRNA, partial cds1,347 bp linear mRNAEU021267.1 GI:154224706342. Influenza A virus (A / Thailand / CU23 / 2006(H3N2)) hemagglutinin (HA) mRNA, complete cds1,701 bp linear mRNAEU021266.1 GI:154224777343. Influenza A virus (A / Thailand / CU231 / 2006(H3N2)) neuraminidase (NA) mRNA, complete cds1,410 bp linear mRNAEU021283.1 GI:154224722344. Influenza A virus (A / Thailand / CU231 / 2006(H3N2)) hemagglutinin (HA) mRNA, complete cds1,701 bp linear mRNAEU021282.1 GI:154224793345. Influenza A virus (A / Thailand / CU259 / 2006(H3N2)) neuraminidase (NA) mRNA, complete cds1,410 bp linear mRNAEU021279.1 GI:154224718346. Influenza A virus (A / Thailand / CU259 / 2006(H3N2)) hemagglutinin (HA) mRNA, complete cds1,701 bp linear mRNAEU021278.1 GI:154224789347. Influenza A virus (A / Thailand / CU260 / 2006(H3N2)) neuraminidase (NA) mRNA, complete cds1,410 bp linear mRNAEU021281.1 GI:154224720348. Influenza A virus (A / Thailand / CU260 / 2006(H3N2)) hemagglutinin (HA) mRNA, partial cds1,129 bp linear mRNAEU021280.1 GI:154224791349. Influenza A virus (A / Thailand / CU272 / 2007(H3N2)) neuraminidase (NA) mRNA, complete cds1,410 bp linear mRNAEU021271.1 GI:154224710350. Influenza A virus (A / Thailand / CU272 / 2007(H3N2)) hemagglutinin (HA) mRNA, complete cds1,701 bp linear mRNAEU021270.1 GI:154224781351. Influenza A virus (A / Thailand / CU280 / 2007(H3N2)) neuraminidase (NA) mRNA, complete cds1,410 bp linear mRNAEU021273.1 GI:154224712352. Influenza A virus (A / Thailand / CU280 / 2007(H3N2)) hemagglutinin (HA) mRNA, complete cds1,701 bp linear mRNAEU021272.1 GI:154224783353. Influenza A virus (A / Thailand / CU282 / 2007(H3N2)) neuraminidase (NA) mRNA, complete cds1,410 bp linear mRNAEU021277.1 GI:154224716354. Influenza A virus (A / Thailand / CU282 / 2007(H3N2)) hemagglutinin (HA) mRNA, complete cds1,701 bp linear mRNAEU021276.1 GI:154224787355. Influenza A virus (A / Thailand / CU32 / 2006(H1N1)) neuraminidase (NA) mRNA, complete cds1,413 bp linear mRNAEU021265.1 GI:154224704361. Influenza A virus (A / Thailand / CU46 / 2006(H3N2)) neuraminidase (NA) mRNA, complete cds1,410 bp linear mRNAEU021269.1 GI:154224708362. Influenza A virus (A / Thailand / CU46 / 2006(H3N2)) hemagglutinin (HA) mRNA, complete cds1,701 bp linear mRNAEU021268.1 GI:154224779377. Influenza A virus (A / Tottori / 849AM1AL3 / 1994(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAU77837.1 GI:2992515378. Influenza A virus (A / Tottori / 849AM2 / 1994(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAU77833.1 GI:2992507379. Influenza A virus (A / Tottori / 849AM2AL3 / 1994(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAU77839.1 GI:2992519380. Influenza A virus (A / Tottori / 849AM4 / 1994(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAU77835.1 GI:2992511382. Influenza A virus (A / Tottori / 872AM2 / 1994(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAU77834.1 GI:2992509383. Influenza A virus (A / Tottori / 872AM2AL3 / 1994(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAU77840.1 GI:2992521384. Influenza A virus (A / Tottori / 872AM4 / 1994(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAU77836.1 GI:2992513385. Influenza A virus (A / Tottori / 872K4 / 1994(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAU77832.1 GI:2992505386. Influenza A virus (A / United Kingdom / 26554 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501529.1 GI:21314314387. Influenza A virus (A / United Kingdom / 34300 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501527.1 GI:21314310388. Influenza A virus (A / Utah / 20997 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501533.1 GI:21314322389. Influenza A virus (A / Victoria / 3 / 75) segment 5 nucleoprotein mRNA, complete cds1,565 bp linear mRNAAF072545.1 GI:4218933390. Influenza A virus (A / Vienna / 47 / 96M(H3N2)) hemagglutinin (HA) mRNA, complete cds1,762 bp linear mRNAAF017270.2 GI:14286338391. Influenza A virus (A / Vienna / 47 / 96V(H3N2)) hemagglutinin (HA) mRNA, complete cds1,762 bp linear mRNAAF017272.2 GI:15004991392. Influenza A virus (A / Vienna / 81 / 96V(H3N2)) hemagglutinin (HA) mRNA, partial cds1,069 bp linear mRNAAF017271.1 GI:2407251393. Influenza A virus (A / Virginia / 21712 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501532.1 GI:21314320394. Influenza A virus (A / Virginia / 21716 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501515.1 GI:21314286395. Influenza A virus (A / Virginia / 21735 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501530.1 GI:21314316396. Influenza A virus (A / Virginia / 21743 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501524.1 GI:21314304397. Influenza A virus (A / Virginia / 21754 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501519.1 GI:21314294398. Influenza A virus (A / Virginia / 21799 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501523.1 GI:21314302399. Influenza A virus (A / Virginia / 21817 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501525.1 GI:21314306400. Influenza A virus (A / Virginia / 21822 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501520.1 GI:21314296401. Influenza A virus (A / Virginia / 21828 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501528.1 GI:21314312402. Influenza A virus (A / Virginia / 21833 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501517.1 GI:21314290403. Influenza A virus (A / Virginia / 21845 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501522.1 GI:21314300404. Influenza A virus (A / Virginia / 21847 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501535.1 GI:21314326405. Influenza A virus (A / Virginia / G1 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAF501521.1 GI:21314298406. Influenza A virus (A / Yilan / 508 / 03(H3N2)) neuraminidase (NA) mRNA, partial cds755 bp linear mRNAAY973339.1 GI:70673234407. Influenza A virus (A / Yilan / 508 / 03(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY986999.1 GI:70728125408. Influenza A virus (A / Yilan / 513 / 03(H3N2)) hemagglutinin (HA) mRNA, partial cds740 bp linear mRNAAY962015.1 GI:68138187409. Influenza A virus (A / Yilan / 513 / 03(H3N2)) neuraminidase (NA) mRNA, partial cds396 bp linear mRNAAY973340.1 GI:70673236410. Influenza A virus (A / Yilan / 513 / 03(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY987000.1 GI:70728127411. Influenza A virus (A / Yilan / 515 / 03(H3N2)) hemagglutinin (HA) mRNA, partial cds511 bp linear mRNAAY962010.1 GI:68138177412. Influenza A virus (A / Yilan / 515 / 03(H3N2)) neuraminidase (NA) mRNA, partial cds394 bp linear mRNAAY973341.1 GI:70673238413. Influenza A virus (A / Yilan / 516 / 03(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY987001.1 GI:70728129414. Influenza A virus (A / Yilan / 518 / 03(H3N2)) hemagglutinin (HA) mRNA, partial cds530 bp linear mRNAAY962006.1 GI:68138169415. Influenza A virus (A / Yilan / 518 / 03(H3N2)) neuraminidase (NA) mRNA, partial cds397 bp linear mRNAAY973342.1 GI:70673240416. Influenza A virus (A / Yilan / 518 / 03(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY987002.1 GI:70728131417. Influenza A virus (A / Yilan / 538 / 04(H3N2)) hemagglutinin (HA) mRNA, partial cds777 bp linear mRNAAY962002.1 GI:68138161418. Influenza A virus (A / Yilan / 538 / 04(H3N2)) neuraminidase (NA) mRNA, partial cds783 bp linear mRNAAY973343.1 GI:70673242419. Influenza A virus (A / Yilan / 538 / 04(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY987003.1 GI:70728133420. Influenza A virus (A / Yilan / 549 / 04(H3N2)) hemagglutinin (HA) mRNA, partial cds788 bp linear mRNAAY962003.1 GI:68138163421. Influenza A virus (A / Yilan / 549 / 04(H3N2)) neuraminidase (NA) mRNA, partial cds779 bp linear mRNAAY973344.1 GI:70673244422. Influenza A virus (A / Yilan / 549 / 04(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY987004.1 GI:70728135423. Influenza A virus (A / Yilan / 557 / 04(H3N2)) hemagglutinin (HA) mRNA, partial cds776 bp linear mRNAAY962013.1 GI:68138183424. Influenza A virus (A / Yilan / 557 / 04(H3N2)) neuraminidase (NA) mRNA, partial cds796 bp linear mRNAAY973345.1 GI:70673246425. Influenza A virus (A / Yilan / 557 / 04(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY987005.1 GI:70728137426. Influenza A virus (A / Yilan / 566 / 04(H3N2)) hemagglutinin (HA) mRNA, partial cds753 bp linear mRNAAY962014.1 GI:68138185427. Influenza A virus (A / Yilan / 566 / 04(H3N2)) neuraminidase (NA) mRNA, partial cds808 bp linear mRNAAY973346.1 GI:70673248428. Influenza A virus (A / Yilan / 566 / 04(H3N2)) nucleoprotein (NP) mRNA, partial cds882 bp linear mRNAAY987006.1 GI:70728139429. Influenza A virus (A / zhejiang / 06 / 99(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAY138513.1 GI:24895131430. Influenza A virus (A / zhejiang / 10 / 98(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAY138515.1 GI:24895149431. Influenza A virus (A / zhejiang / 11 / 2002(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAY138516.1 GI:24895159432. Influenza A virus (A / zhejiang / 12 / 99(H3N2)) hemagglutinin-like (HA) mRNA, partial sequence987 bp linear mRNAAY138514.1 GI:24895141433. Influenza A virus (A / zhejiang / 8 / 2002(H3N2)) hemagglutinin (HA) mRNA, partial cds987 bp linear mRNAAY138519.1 GI:24895188434. Influenza A virus H3N2 strain A / Akita / 1 / 94 nonstructural protein 1 and nonstructural protein 2 mRNAs, complete cds840 bp linear mRNAU65670.1 GI:3929405435. Influenza A virus H3N2 strain A / Akita / 1 / 95 nonstructural protein 1 and nonstructural protein 2 mRNAs, complete cds840 bp linear mRNAU65671.1 GI:3929408436. Influenza A virus H3N2 strain A / Shiga / 20 / 95 nonstructural protein 1 and nonstructural protein 2 mRNAs, complete cds840 bp linear mRNAU65673.1 GI:3929411437. Influenza A virus H3N2 strain A / Miyagi / 69 / 95 nonstructural protein 1 and nonstructural protein 2 mRNAs, complete cds840 bp linear mRNAU65674.1 GI:3929414438. Influenza A virus H3N2 strain A / Hebei / 19 / 95 nonstructural protein 1 and nonstructural protein 2 mRNAs, complete cds840 bp linear mRNAU65672.1 GI:6468319A / Aichi / 69 / 1994(H3N2) haemagglutininU48446.1A / Bangkok / 1 / 1979 (H3N2) hemagglutinin (HA)AF201843.1A / Beijing / 353 / 89(H3) hemagglutinin (HA)U97740.1A / Beijing / 353 / 1989(H3N2) haemagglutininZ46391.1A / chicken / Singapore / 2002(H3N2) M2 proteinEU014143.1A / Christ Hospital / 231 / 82(H3N2)) hemagglutinin (HA)U77830.1A / duck / Eastern China / 36 / 2002(H3N2) segment 6 neuraminidase (NA)EU429701.1A / duck / Eastern China / 160 / 2003(H3N2) segment 6 neuraminidase (NA)EU429732.1A / duck / Eastern China / 848 / 2003(H3N2) segment 6 neuraminidase (NA)EU429721.1A / duck / Eastern China / 770 / 2003(H3N2) segment 6 neuraminidase (NA)EU429736.1A / duck / Eastern China / 855 / 2003(H3N2) segment 6 neuraminidase (NA)EU429737.1A / duck / Eastern China / 875 / 2003(H3N2) segment 6 neuraminidase (NA)EU429738.1A / duck / Eastern China / 901 / 2003(H3N2) segment 6 neuraminidase (NA)EU429739.1A / duck / Eastern China / 866 / 2003(H3N2) segment 6 neuraminidase (NA)EU429756.1A / duck / Eastern China / 857 / 2003(H3N2) segment 6 neuraminidase (NA)EU429761.1A / duck / Eastern China / 852 / 2003(H3N2) segment 6 neuraminidase (NA)EU429767.1A / duck / Eastern China / 838 / 2003(H3N2) segment 6 neuraminidase (NA)EU429720.1A / duck / Eastern China / 6 / 2004(H3N2) segment 6 neuraminidase (NA)EU429745.1A / duck / Eastern China / 03 / 2005(H3N2) segment 6 neuraminidase (NA)EU429781.1A / duck / Eastern China / 02 / 2006(H3N2) segment 6 neuraminidase (NA)EU429769.1A / duck / Eastern China / 04 / 2006(H3N2) segment 6 neuraminidase (NA)EU429770.1A / duck / Eastern China / 21 / 2006(H3N2) segment 6 neuraminidase (NA)EU429771.1A / duck / Eastern China / 23 / 2006(H3N2) segment 6 neuraminidase (NA)EU429772.1A / duck / Eastern China / 31 / 2006(H3N2) segment 6 neuraminidase (NA)EU429773.1A / duck / Eastern China / 35 / 2006(H3N2) segment 6 neuraminidase (NA)EU429768.1A / duck / Eastern China / 42 / 2006(H3N2) segment 6 neuraminidase (NA)EU429774.1A / duck / Eastern China / 53 / 2006(H3N2) segment 6 neuraminidase (NA)EU429775.1A / duck / Eastern China / 60 / 2006(H3N2) segment 6 neuraminidase (NA)EU429776.1A / duck / Eastern China / 62 / 2006(H3N2) segment 6 neuraminidase (NA)EU429784.1A / duck / Eastern China / 63 / 2006(H3N2) segment 6 neuraminidase (NA)EU429777.1A / duck / Eastern China / 142 / 2006(H3N2) segment 6 neuraminidase (NA)EU429742.1A / Dunedin / 4 / 1973 (H3N2) hemagglutinin (HA)AF201842.1 Table 8. Influenza H5N1 Antigens 1. Influenza A virus (A / chicken / Burkina Faso / 01.03 / 2006(H5N1)) mRNA for non-structural protein (ns gene)827 bp linear mRNAAM503036.1 GI:1478463082. Influenza A virus (A / chicken / Burkina Faso / 13.1 / 2006(H5N1)) partial mRNA for matrix protein 1 (m1 gene)990 bp linear mRNAAM503007.1 GI:1478462503. Influenza A virus (A / chicken / Burkina Faso / 13.1 / 2006(H5N1)) mRNA for nucleoprotein (np gene)1,529 bp linear mRNAAM503029.1 GI:1478462944. Influenza A virus (A / chicken / Burkina Faso / 13.1 / 2006(H5N1)) mRNA for non-structural protein (ns gene)827 bp linear mRNAAM503037.1 GI:1478463105. Influenza A virus (A / chicken / Burkina Faso / 13.1 / 2006(H5N1)) partial mRNA for polymerase (pa gene)2,169 bp linear mRNAAM503046.1 GI:1478463286. Influenza A virus (A / chicken / Burkina Faso / 13.1 / 2006(H5N1)) partial mRNA for polymerase basic protein 1 (pb1 gene)2,259 bp linear mRNAAM503056.1 GI:1478463487. Influenza A virus (A / chicken / Burkina Faso / 13.1 / 2006(H5N1)) partial mRNA for polymerase basic protein 2 (pb2 gene)2,315 bp linear mRNAAM503067.1 GI:1478468598. Influenza A virus (A / chicken / China / 1 / 02(H5N1)) hemagglutinin (HA) mRNA, complete cds1,736 bp linear mRNADQ023145.1 GI:667756249. Influenza A virus (A / chicken / China / 1 / 02(H5N1)) nucleoprotein (NP) mRNA, complete cds1,509 bp linear mRNADQ023146.1 GI:6677562610. Influenza A virus (A / chicken / China / 1 / 02(H5N1)) neuraminidase (NA) mRNA, complete cds1,379 bp linear mRNADQ023147.1 GI:6677562811. Influenza A virus (A / chicken / Crimea / 04 / 2005(H5N1)) matrix protein (M) mRNA, complete cds999 bp linear mRNADQ650660.1 GI:10969276712. Influenza A virus (A / chicken / Crimea / 04 / 2005(H5N1)) nonstructural protein (NS) mRNA, complete cds850 bp linear mRNADQ650662.1 GI:10969277113. Influenza A virus (A / chicken / Crimea / 08 / 2005(H5N1)) matrix protein (M) mRNA, complete cds994 bp linear mRNADQ650664.1 GI:10969277514. Influenza A virus (A / chicken / Crimea / 08 / 2005(H5N1)) nucleoprotein (NP) mRNA, complete cds1,532 bp linear mRNADQ650666.1 GI:10969277915. Influenza A virus (A / chicken / Crimea / 08 / 2005(H5N1)) nonstructural protein (NS) mRNA, complete cds850 bp linear mRNADQ650667.1 GI:10969278116. Influenza A virus (A / chicken / Crimea / 08 / 2005(H5N1)) polymerase acidic protein (PA) mRNA, complete cds2,208 bp linear mRNADQ650668.1 GI:10969278317. Influenza A virus (A / chicken / Crimea / 08 / 2005(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,305 bp linear mRNADQ650670.1 GI:10969278718. Influenza A virus (A / chicken / Dovolnoe / 03 / 2005(H5N1)) hemagglutinin (HA) mRNA, partial cds1,015 bp linear mRNADQ676838.1 GI:10878252720. Influenza A virus (A / chicken / Guangxi / 12 / 2004(H5N1)) polymerase PB2 mRNA, complete cds2,341 bp linear mRNADQ366327.1 GI:8675373121. Influenza A virus (A / chicken / Guangxi / 12 / 2004(H5N1)) polymerase PB1 mRNA, complete cds2,341 bp linear mRNADQ366328.1 GI:8675374122. Influenza A virus (A / chicken / Guangxi / 12 / 2004(H5N1)) PA protein mRNA, complete cds2,233 bp linear mRNADQ366329.1 GI:8675375123. Influenza A virus (A / chicken / Guangxi / 12 / 2004(H5N1)) nucleocapsid mRNA, complete cds1,565 bp linear mRNADQ366331.1 GI:8675377124. Influenza A virus (A / chicken / Guangxi / 12 / 2004(H5N1)) matrix protein mRNA, complete cds1,027 bp linear mRNADQ366333.1 GI:8675379125. Influenza A virus (A / chicken / Hong Kong / 258 / 97(H5N1)) hemagglutinin mRNA, complete cds1,718 bp linear mRNAAF057291.1 GI:306872026. Influenza A virus (A / chicken / Hong Kong / 258 / 97(H5N1)) neuraminidase mRNA, partial cds1,318 bp linear mRNAAF057292.1 GI:306872227. Influenza A virus (A / chicken / Hong Kong / 258 / 97(H5N1)) nucleoprotein mRNA, complete cds1,508 bp linear mRNAAF057293.1 GI:306872428. Influenza A virus (A / Chicken / Hong Kong / 728 / 97 (H5N1)) hemagglutinin H5 mRNA, complete cds1,726 bp linear mRNAAF082034.1 GI:424043529. Influenza A virus (A / Chicken / Hong Kong / 786 / 97 (H5N1)) hemagglutinin H5 mRNA, complete cds1,726 bp linear mRNAAF082035.1 GI:424043730. Influenza A virus (A / chicken / Hong Kong / 915 / 97(H5N1)) hemagglutinin H5 mRNA, complete cds1,726 bp linear mRNAAF082036.1 GI:424043931. Influenza A virus (A / chicken / Hong Kong / 990 / 97 (H5N1)) hemagglutinin H5 mRNA, partial cds1,091 bp linear mRNAAF082037.1 GI:424044132. Influenza A virus (A / chicken / Krasnodar / 01 / 2006(H5N1)) matrix protein 1 (M) mRNA, complete cds1,002 bp linear mRNADQ676835.1 GI:10878252133. Influenza A virus (A / chicken / Krasnodar / 01 / 2006(H5N1)) nonstructural protein (NS) mRNA, complete cds850 bp linear mRNADQ676837.1 GI:10878252534. Influenza A virus (A / chicken / Kurgan / 05 / 2005(H5N1)) hemagglutinin (HA) mRNA, complete cds1,754 bp linear mRNADQ449632.1 GI:9028962535. Influenza A virus (A / chicken / Kurgan / 05 / 2005(H5N1)) matrix protein 1 (M) mRNA, complete cds1,002 bp linear mRNADQ449633.1 GI:9028962736. Influenza A virus (A / chicken / Kurgan / 05 / 2005(H5N1)) neuraminidase (NA) mRNA, complete cds1,373 bp linear mRNADQ449634.1 GI:9028962937. Influenza A virus (A / chicken / Kurgan / 05 / 2005(H5N1)) nucleoprotein (NP) mRNA, complete cds1,540 bp linear mRNADQ449635.1 GI:9028963138. Influenza A virus (A / chicken / Kurgan / 05 / 2005(H5N1)) nonstructural protein (NS) mRNA, complete cds850 bp linear mRNADQ449636.1 GI:9028963339. Influenza A virus (A / chicken / Kurgan / 05 / 2005(H5N1)) polymerase acidic protein (PA) mRNA, complete cds2,208 bp linear mRNADQ449637.1 GI:9028963540. Influenza A virus (A / chicken / Kurgan / 05 / 2005(H5N1)) polymerase basic protein 1 (PB1) mRNA, complete cds2,316 bp linear mRNADQ449638.1 GI:9028963741. Influenza A virus (A / chicken / Kurgan / 05 / 2005(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,316 bp linear mRNADQ449639.1 GI:9028964642. Influenza A virus (A / chicken / Lobzenko / 01 / 2008(H5N1)) hemagglutinin (HA) mRNA, partial cds184 bp linear mRNAEU447276.1 GI:16899821743. Influenza A virus (A / chicken / Mahachkala / 05 / 2006(H5N1)) matrix protein 1 (M) mRNA, complete cds1,002 bp linear mRNADQ676831.1 GI:10878251344. Influenza A virus (A / chicken / Mahachkala / 05 / 2006(H5N1)) nonstructural protein (NS) mRNA, complete cds850 bp linear mRNADQ676833.1 GI:10878251745. Influenza A virus (A / chicken / Nigeria / AB13 / 2006(H5N1)) mRNA for nucleoprotein (np gene)1,531 bp linear mRNAAM503030.1 GI:14784629646. Influenza A virus (A / chicken / Nigeria / AB13 / 2006(H5N1)) mRNA for non-structural protein (ns gene)827 bp linear mRNAAM503040.1 GI:14784631647. Influenza A virus (A / chicken / Nigeria / AB13 / 2006(H5N1)) partial mRNA for polymerase (pa gene)2,169 bp linear mRNAAM503051.1 GI:14784633848. Influenza A virus (A / chicken / Nigeria / AB13 / 2006(H5N1)) partial mRNA for polymerase basic protein 1 (pb1 gene)2,259 bp linear mRNAAM503060.1 GI:14784684549. Influenza A virus (A / chicken / Nigeria / AB13 / 2006(H5N1)) partial mRNA for polymerase basic protein 2 (pb2 gene)2,315 bp linear mRNAAM503071.1 GI:14784686770. Influenza A virus (A / chicken / Hong Kong / 3123.1 / 2002(H5N1)) neuraminidase (NA) mRNA, partial cds1,055 bp linear mRNADQ250158.1 GI:8241201275. Influenza A virus (A / chicken / Krasnodar / 01 / 2006(H5N1)) hemagglutinin (HA) mRNA, complete cds1,754 bp linear mRNADQ676834.1 GI:10878251978. Influenza A virus (A / chicken / Krasnodar / 01 / 2006(H5N1)) neuraminidase (NA) mRNA, complete cds1,373 bp linear mRNADQ676836.2 GI:11552095391. Influenza A virus (A / chicken / Lobzenko / 01 / 2008(H5N1)) hemagglutinin (HA) mRNA, partial cds184 bp linear mRNAEU447276.1 GI:16899821792. Influenza A virus (A / chicken / Mahachkala / 05 / 2006(H5N1)) hemagglutinin (HA) mRNA, complete cds1,683 bp linear mRNADQ676830.1 GI:10878251194. Influenza A virus (A / chicken / Mahachkala / 05 / 2006(H5N1)) neuraminidase (NA) mRNA, complete cds1,373 bp linear mRNADQ676832.1 GI:10878251596. Influenza A virus (A / chicken / Malaysia / 01 / 2004(H5N1)) neuramidase (NA) mRNA, partial cds433 bp linear mRNADQ096567.1 GI:6914536497. Influenza A virus (A / chicken / Nigeria / AB13 / 2006(H5N1)) partial mRNA for hemagglutinin (ha gene)1,722 bp linear mRNAAM503002.1 GI:14784624098. Influenza A virus (A / chicken / Nigeria / AB13 / 2006(H5N1)) partial mRNA for neuraminidase (na gene)1,329 bp linear mRNAAM503020.1 GI:147846276105. Influenza A virus (A / chicken / Nigeria / AB14 / 2006(H5N1)) partial mRNA for hemagglutinin (ha gene)1,719 bp linear mRNAAM503003.1 GI:147846242106. Influenza A virus (A / chicken / Nigeria / AB14 / 2006(H5N1)) partial mRNA for matrix protein 1 (m1 gene)953 bp linear mRNAAM503011.1 GI:147846258107. Influenza A virus (A / chicken / Nigeria / AB14 / 2006(H5N1)) partial mRNA for neuraminidase (na gene)1,343 bp linear mRNAAM503025.1 GI:147846286108. Influenza A virus (A / chicken / Nigeria / AB14 / 2006(H5N1)) mRNA for non-structural protein (ns gene)827 bp linear mRNAAM503041.1 GI:147846318109. Influenza A virus (A / chicken / Nigeria / AB14 / 2006(H5N1)) partial mRNA for polymerase (pa gene)2,169 bp linear mRNAAM503054.1 GI:147846344110. Influenza A virus (A / chicken / Nigeria / AB14 / 2006(H5N1)) partial mRNA for polymerase basic protein 1 (pb1 gene)2,259 bp linear mRNAAM503061.1 GI:147846847111. Influenza A virus (A / chicken / Nigeria / AB14 / 2006(H5N1)) partial mRNA for polymerase basic protein 2 (pb2 gene)2,315 bp linear mRNAAM503072.1 GI:147846869112. Influenza A virus (A / chicken / Nigeria / AB14 / 2006(H5N1)) mRNA for nucleoprotein (np gene)1,548 bp linear mRNAAM503034.2 GI:149773117113. Influenza A virus (A / chicken / Nigeria / BA210 / 2006(H5N1)) partial mRNA for neuraminidase (na gene)1,342 bp linear mRNAAM503022.1 GI:147846280114. Influenza A virus (A / chicken / Nigeria / BA211 / 2006(H5N1)) partial mRNA for neuraminidase (na gene)1,321 bp linear mRNAAM503021.1 GI:147846278115. Influenza A virus (A / chicken / Nigeria / BA211 / 2006(H5N1)) partial mRNA for polymerase basic protein 2 (pb2 gene)2,315 bp linear mRNAAM503073.1 GI:147846871116. Influenza A virus (A / chicken / Nigeria / FA4 / 2006(H5N1)) partial mRNA for hemagglutinin (ha gene)1,717 bp linear mRNAAM503004.1 GI:147846244117. Influenza A virus (A / chicken / Nigeria / FA4 / 2006(H5N1)) partial mRNA for matrix protein 1 (m1 gene)989 bp linear mRNAAM503013.1 GI:147846262118. Influenza A virus (A / chicken / Nigeria / FA4 / 2006(H5N1)) partial mRNA for neuraminidase (na gene)1,321 bp linear mRNAAM503026.1 GI:147846288119. Influenza A virus (A / chicken / Nigeria / FA4 / 2006(H5N1)) mRNA for non-structural protein (ns gene)827 bp linear mRNAAM503045.1 GI:147846326120. Influenza A virus (A / chicken / Nigeria / FA4 / 2006(H5N1)) partial mRNA for polymerase (pa gene)2,169 bp linear mRNAAM503055.1 GI:147846346121. Influenza A virus (A / chicken / Nigeria / FA4 / 2006(H5N1)) partial mRNA for polymerase basic protein 1 (pb1 gene)2,259 bp linear mRNAAM503064.1 GI:147846853122. Influenza A virus (A / chicken / Nigeria / FA4 / 2006(H5N1)) partial mRNA for polymerase basic protein 2 (pb2 gene)2,224 bp linear mRNAAM503074.1 GI:147846873123. Influenza A virus (A / chicken / Nigeria / FA6 / 2006(H5N1)) partial mRNA for hemagglutinin (ha gene)1,717 bp linear mRNAAM502998.1 GI:147846232124. Influenza A virus (A / chicken / Nigeria / FA6 / 2006(H5N1)) partial mRNA for matrix protein 1 (m1 gene)965 bp linear mRNAAM503012.1 GI:147846260125. Influenza A virus (A / chicken / Nigeria / FA6 / 2006(H5N1)) partial mRNA for neuraminidase (na gene)1,327 bp linear mRNAAM503023.1 GI:147846282126. Influenza A virus (A / chicken / Nigeria / FA6 / 2006(H5N1)) mRNA for nucleoprotein (np gene)1,543 bp linear mRNAAM503031.1 GI:147846298127. Influenza A virus (A / chicken / Nigeria / FA6 / 2006(H5N1)) partial mRNA for polymerase (pa gene)2,169 bp linear mRNAAM503052.1 GI:147846340128. Influenza A virus (A / chicken / Nigeria / FA6 / 2006(H5N1)) partial mRNA for polymerase basic protein 1 (pb1 gene)2,259 bp linear mRNAAM503063.1 GI:147846851129. Influenza A virus (A / chicken / Nigeria / FA7 / 2006(H5N1)) partial mRNA for hemagglutinin (ha gene)1,710 bp linear mRNAAM502999.1 GI:147846234130. Influenza A virus (A / chicken / Nigeria / FA7 / 2006(H5N1)) partial mRNA for matrix protein 1 (m1 gene)1,001 bp linear mRNAAM503009.1 GI:147846254131. Influenza A virus (A / chicken / Nigeria / FA7 / 2006(H5N1)) partial mRNA for neuraminidase (na gene)1,331 bp linear mRNAAM503018.1 GI:147846272132. Influenza A virus (A / chicken / Nigeria / FA7 / 2006(H5N1)) mRNA for nucleoprotein (np gene)1,531 bp linear mRNAAM503035.1 GI:147846306133. Influenza A virus (A / chicken / Nigeria / FA7 / 2006(H5N1)) mRNA for non-structural protein (ns gene)827 bp linear mRNAAM503042.1 GI:147846320134. Influenza A virus (A / chicken / Nigeria / FA7 / 2006(H5N1)) partial mRNA for polymerase (pa gene)2,169 bp linear mRNAAM503049.1 GI:147846334135. Influenza A virus (A / chicken / Nigeria / FA7 / 2006(H5N1)) partial mRNA for polymerase basic protein 1 (pb1 gene)2,259 bp linear mRNAAM503057.1 GI:147846350136. Influenza A virus (A / chicken / Nigeria / FA7 / 2006(H5N1)) partial mRNA for polymerase basic protein 2 (pb2 gene)2,315 bp linear mRNAAM503068.1 GI:147846861137. Influenza A virus (A / chicken / Nigeria / IF10 / 2006(H5N1)) partial mRNA for hemagglutinin (ha gene)1,714 bp linear mRNAAM503001.1 GI:147846238138. Influenza A virus (A / chicken / Nigeria / IF10 / 2006(H5N1)) partial mRNA for matrix protein 1 (m1 gene)990 bp linear mRNAAM503010.1 GI:147846256139. Influenza A virus (A / chicken / Nigeria / IF10 / 2006(H5N1)) partial mRNA for neuraminidase (na gene)1,332 bp linear mRNAAM503024.1 GI:147846284140. Influenza A virus (A / chicken / Nigeria / IF10 / 2006(H5N1)) mRNA for non-structural protein (ns gene)827 bp linear mRNAAM503044.1 GI:147846324141. Influenza A virus (A / chicken / Nigeria / IF10 / 2006(H5N1)) partial mRNA for polymerase (pa gene)2,169 bp linear mRNAAM503053.1 GI:147846342142. Influenza A virus (A / chicken / Nigeria / IF10 / 2006(H5N1)) partial mRNA for polymerase basic protein 1 (pb1 gene)2,259 bp linear mRNAAM503059.1 GI:147846843143. Influenza A virus (A / chicken / Nigeria / IF10 / 2006(H5N1)) partial mRNA for polymerase basic protein 2 (pb2 gene)2,315 bp linear mRNAAM503069.1 GI:147846863144. Influenza A virus (A / chicken / Nigeria / IF10 / 2006(H5N1)) mRNA for nucleoprotein (np gene)1,550 bp linear mRNAAM503033.2 GI:149773115145. Influenza A virus (A / chicken / Nigeria / OD8 / 2006(H5N1)) partial mRNA for hemagglutinin (ha gene)1,719 bp linear mRNAAM503005.1 GI:147846246146. Influenza A virus (A / chicken / Nigeria / OD8 / 2006(H5N1)) partial mRNA for matrix protein 1 (m1 gene)989 bp linear mRNAAM503014.1 GI:147846264147. Influenza A virus (A / chicken / Nigeria / OD9 / 2006(H5N1)) partial mRNA for hemagglutinin (ha gene)1,720 bp linear mRNAAM503000.1 GI:147846236148. Influenza A virus (A / chicken / Nigeria / OD9 / 2006(H5N1)) partial mRNA for matrix protein 1 (m1 gene)988 bp linear mRNAAM503015.1 GI:147846266149. Influenza A virus (A / chicken / Nigeria / OD9 / 2006(H5N1)) partial mRNA for neuraminidase (na gene)1,330 bp linear mRNAAM503019.1 GI:147846274150. Influenza A virus (A / chicken / Nigeria / OD9 / 2006(H5N1)) mRNA for nucleoprotein (np gene)1,531 bp linear mRNAAM503032.1 GI:147846300151. Influenza A virus (A / chicken / Nigeria / OD9 / 2006(H5N1)) mRNA for non-structural protein (ns gene)827 bp linear mRNAAM503043.1 GI:147846322152. Influenza A virus (A / chicken / Nigeria / OD9 / 2006(H5N1)) partial mRNA for polymerase (pa gene)2,169 bp linear mRNAAM503050.1 GI:147846336153. Influenza A virus (A / chicken / Nigeria / OD9 / 2006(H5N1)) partial mRNA for polymerase basic protein 1 (pb1 gene)2,259 bp linear mRNAAM503058.1 GI:147846841154. Influenza A virus (A / chicken / Nigeria / OD9 / 2006(H5N1)) partial mRNA for polymerase basic protein 2 (pb2 gene)2,315 bp linear mRNAAM503070.1 GI:147846865155. Influenza A virus (A / chicken / Scotland / 59(H5N1)) mRNA for haemagglutinin precursor1,768 bp linear mRNAX07869.1 GI:60482156. Influenza A virus (A / chicken / Scotland / 59(H5N1)) N1 gene for neuraminidase, genomic RNA1,445 bp linear mRNAAJ416625.1 GI:39840717161. Influenza A virus (A / chicken / zz / 02 / 2004(H5N1)) nucleoprotein mRNA, complete cds1,497 bp linear mRNADQ208502.1 GI:77158587162. Influenza A virus (A / common coot / Switzerland / V544 / 2006(H5N1)) hemagglutinin (HA) gene, complete cds1,707 bp linear mRNAEF110519.1 GI:119394676163. Influenza A virus (A / domestic goose / Pavlodar / 1 / 2005(H5N1)) hemagglutinin (HA) mRNA, complete cds1,735 bp linear mRNAEU190482.1 GI:158516739164. Influenza A virus (A / duck / Eastern China / 145 / 2003(H5N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,401 bp linear mRNAEU429750.1 GI:167859465165. Influenza A virus (A / duck / Eastern China / 150 / 2003(H5N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,407 bp linear mRNAEU429731.1 GI:167859427166. Influenza A virus (A / duck / Eastern China / 22 / 2005(H5N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,398 bp linear mRNAEU429783.1 GI:167859531167. Influenza A virus (A / duck / Eastern China / 304 / 2002(H5N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,398 bp linear mRNAEU429747.1 GI:167859459168. Influenza A virus (A / duck / Eastern China / 318 / 2002(H5N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,401 bp linear mRNAEU429727.1 GI:167859419169. Influenza A virus (A / duck / Eastern China / 37 / 2006(H5N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,399 bp linear mRNAEU429778.1 GI:167859521170. Influenza A virus (A / duck / Eastern China / 40 / 2005(H5N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,398 bp linear mRNAEU429757.1 GI:167859479171. Influenza A virus (A / duck / Eastern China / 48 / 2006(H5N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,398 bp linear mRNAEU429779.1 GI:167859523172. Influenza A virus (A / duck / Eastern China / 51 / 2005(H5N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,398 bp linear mRNAEU429763.1 GI:167859491173. Influenza A virus (A / duck / Eastern China / 54 / 2005(H5N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,398 bp linear mRNAEU429758.1 GI:167859481174. Influenza A virus (A / duck / Eastern China / 58 / 2005(H5N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,398 bp linear mRNAEU429764.1 GI:167859493175. Influenza A virus (A / duck / Eastern China / 59 / 2005(H5N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,398 bp linear mRNAEU429759.1 GI:167859483176. Influenza A virus (A / duck / Eastern China / 89 / 2005(H5N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,398 bp linear mRNAEU429765.1 GI:167859495177. Influenza A virus (A / duck / Eastern China / 89 / 2006(H5N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,399 bp linear mRNAEU429785.1 GI:167859535178. Influenza A virus (A / duck / Eastern China / 97 / 2001(H5N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,398 bp linear mRNAEU429717.1 GI:167859399179. Influenza A virus (A / duck / Fujian / 01 / 2002(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585504.1 GI:47156226180. Influenza A virus (A / duck / Fujian / 01 / 2002(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585378.1 GI:47156310181. Influenza A virus (A / duck / Fujian / 01 / 2002(H5N1)) neuraminidase (NA) mRNA, complete cds1,357 bp linear mRNAAY585399.1 GI:47156352182. Influenza A virus (A / duck / Fujian / 01 / 2002(H5N1)) nucleoprotein (NP) mRNA, complete cds1,497 bp linear mRNAAY585420.1 GI:47156394183. Influenza A virus (A / duck / Fujian / 01 / 2002(H5N1)) nonstructural protein 1 (NS1) mRNA, partial cds686 bp linear mRNAAY585441.1 GI:47156436184. Influenza A virus (A / duck / Fujian / 13 / 2002(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585505.1 GI:47156228185. Influenza A virus (A / duck / Fujian / 13 / 2002(H5N1)) matrix protein mRNA, complete cds761 bp linear mRNAAY585379.1 GI:47156312186. Influenza A virus (A / duck / Fujian / 13 / 2002(H5N1)) neuraminidase (NA) mRNA, complete cds1,357 bp linear mRNAAY585400.1 GI:47156354187. Influenza A virus (A / duck / Fujian / 13 / 2002(H5N1)) nucleoprotein (NP) mRNA, complete cds1,499 bp linear mRNAAY585421.1 GI:47156396188. Influenza A virus (A / duck / Fujian / 13 / 2002(H5N1)) nonstructural protein 1 (NS1) mRNA, partial cds685 bp linear mRNAAY585442.1 GI:47156438189. Influenza A virus (A / duck / Fujian / 17 / 2001(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585506.1 GI:47156230190. Influenza A virus (A / duck / Fujian / 17 / 2001(H5N1)) matrix protein mRNA, complete cds759 bp linear mRNAAY585380.1 GI:47156314191. Influenza A virus (A / duck / Fujian / 17 / 2001(H5N1)) neuraminidase (NA) mRNA, complete cds1,418 bp linear mRNAAY585401.1 GI:47156356192. Influenza A virus (A / duck / Fujian / 17 / 2001(H5N1)) nucleoprotein (NP) mRNA, complete cds1,498 bp linear mRNAAY585422.1 GI:47156398193. Influenza A virus (A / duck / Fujian / 17 / 2001(H5N1)) nonstructural protein 1 (NS1) mRNA, complete cds686 bp linear mRNAAY585443.1 GI:47156440194. Influenza A virus (A / duck / Fujian / 19 / 2000(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585507.1 GI:47156232.195. Influenza A virus (A / duck / Fujian / 19 / 2000(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585381.1 GI:47156316196. Influenza A virus (A / duck / Fujian / 19 / 2000(H5N1)) neuraminidase (NA) mRNA, complete cds1,355 bp linear mRNAAY585402.1 GI:47156358197. Influenza A virus (A / duck / Fujian / 19 / 2000(H5N1)) nucleoprotein (NP) mRNA, complete cds1,498 bp linear mRNAAY585423.1 GI:47156400198. Influenza A virus (A / duck / Fujian / 19 / 2000(H5N1)) nonstructural protein 1 (NS1) mRNA, complete cds687 bp linear mRNAAY585444.1 GI:47156442199. Influenza A virus (A / duck / Guangdong / 01 / 2001(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585508.1 GI:47156234200. Influenza A virus (A / duck / Guangdong / 01 / 2001(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585382.1 GI:47156318201. Influenza A virus (A / duck / Guangdong / 01 / 2001(H5N1)) neuraminidase (NA) mRNA, complete cds1,414 bp linear mRNAAY585403.1 GI:47156360202. Influenza A virus (A / duck / Guangdong / 01 / 2001(H5N1)) nucleoprotein (NP) mRNA, complete cds1,497 bp linear mRNAAY585424.1 GI:47156402203. Influenza A virus (A / duck / Guangdong / 01 / 2001(H5N1)) nonstructural protein 1 (NS1) mRNA, complete cds687 bp linear mRNAAY585445.1 GI:47156444204. Influenza A virus (A / duck / Guangdong / 07 / 2000(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,280 bp linear mRNAAY585509.1 GI:47156236205. Influenza A virus (A / duck / Guangdong / 07 / 2000(H5N1)) matrix protein mRNA, complete cds759 bp linear mRNAAY585383.1 GI:47156320206. Influenza A virus (A / duck / Guangdong / 07 / 2000(H5N1)) neuraminidase (NA) mRNA, complete cds1,417 bp linear mRNAAY585404.1 GI:47156362207. Influenza A virus (A / duck / Guangdong / 07 / 2000(H5N1)) nucleoprotein (NP) mRNA, complete cds1,497 bp linear mRNAAY585425.1 GI:47156404208. Influenza A virus (A / duck / Guangdong / 07 / 2000(H5N1)) nonstructural protein 1 (NS1) mRNA, partial cds690 bp linear mRNAAY585446.1 GI:47156446209. Influenza A virus (A / duck / Guangdong / 12 / 2000(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585510.1 GI:47156238210. Influenza A virus (A / duck / Guangdong / 12 / 2000(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585384.1 GI:47156322211. Influenza A virus (A / duck / Guangdong / 12 / 2000(H5N1)) neuraminidase (NA) mRNA, complete cds1,359 bp linear mRNAAY585405.1 GI:47156364212. Influenza A virus (A / duck / Guangdong / 12 / 2000(H5N1)) nucleoprotein (NP) mRNA, complete cds1,498 bp linear mRNAAY585426.1 GI:47156406213. Influenza A virus (A / duck / Guangdong / 12 / 2000(H5N1)) nonstructural protein 1 (NS1) mRNA, partial cds685 bp linear mRNAAY585447.1 GI:47156448214. Influenza A virus (A / duck / Guangdong / 22 / 2002(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585511.1 GI:47156240215. Influenza A virus (A / duck / Guangdong / 22 / 2002(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585385.1 GI:47156324216. Influenza A virus (A / duck / Guangdong / 22 / 2002(H5N1)) neuraminidase (NA) mRNA, complete cds1,412 bp linear mRNAAY585406.1 GI:47156366217. Influenza A virus (A / duck / Guangdong / 22 / 2002(H5N1)) nucleoprotein (NP) mRNA, complete cds1,499 bp linear mRNAAY585427.1 GI:47156408218. Influenza A virus (A / duck / Guangdong / 22 / 2002(H5N1)) nonstructural protein 1 (NS1) mRNA, complete cds682 bp linear mRNAAY585448.1 GI:47156450219. Influenza A virus (A / duck / Guangdong / 40 / 2000(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585512.1 GI:47156242220. Influenza A virus (A / duck / Guangdong / 40 / 2000(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585386.1 GI:47156326221. Influenza A virus (A / duck / Guangdong / 40 / 2000(H5N1)) neuraminidase (NA) mRNA, partial cds1,401 bp linear mRNAAY585407.1 GI:47156368222. Influenza A virus (A / duck / Guangdong / 40 / 2000(H5N1)) nucleoprotein (NP) mRNA, complete cds1,499 bp linear mRNAAY585428.1 GI:47156410223. Influenza A virus (A / duck / Guangdong / 40 / 2000(H5N1)) nonstructural protein 1 (NS1) mRNA, partial cds689 bp linear mRNAAY585449.1 GI:47156452224. Influenza A virus (A / duck / Guangxi / 07 / 1999(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585513.1 GI:47156244225. Influenza A virus (A / duck / Guangxi / 07 / 1999(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585387.1 GI:47156328226. Influenza A virus (A / duck / Guangxi / 07 / 1999(H5N1)) neuraminidase (NA) mRNA, complete cds1,421 bp linear mRNAAY585408.1 GI:47156370227. Influenza A virus (A / duck / Guangxi / 07 / 1999(H5N1)) nucleoprotein (NP) mRNA, complete cds1,501 bp linear mRNAAY585429.1 GI:47156412228. Influenza A virus (A / duck / Guangxi / 07 / 1999(H5N1)) nonstructural protein 1 (NS1) mRNA, partial cds687 bp linear mRNAAY585450.1 GI:47156454229. Influenza A virus (A / duck / Guangxi / 13 / 2004(H5N1)) nonstructural protein 1 mRNA, complete cds875 bp linear mRNADQ366342.1 GI:86753723230. Influenza A virus (A / duck / Guangxi / 13 / 2004(H5N1)) polymerase PB2 mRNA, complete cds2,341 bp linear mRNADQ366335.1 GI:86753733231. Influenza A virus (A / duck / Guangxi / 13 / 2004(H5N1)) polymerase PB1 mRNA, complete cds2,341 bp linear mRNADQ366336.1 GI:86753743232. Influenza A virus (A / duck / Guangxi / 13 / 2004(H5N1)) PA protein mRNA, complete cds2,233 bp linear mRNADQ366337.1 GI:86753753233. Influenza A virus (A / duck / Guangxi / 13 / 2004(H5N1)) hemagglutinin mRNA, complete cds1,776 bp linear mRNADQ366338.1 GI:86753763234. Influenza A virus (A / duck / Guangxi / 13 / 2004(H5N1)) nucleocapsid mRNA, complete cds1,565 bp linear mRNADQ366339.1 GI:86753773235. Influenza A virus (A / duck / Guangxi / 13 / 2004(H5N1)) neuraminidase mRNA, complete cds1,378 bp linear mRNADQ366340.1 GI:86753783236. Influenza A virus (A / duck / Guangxi / 13 / 2004(H5N1)) matrix protein mRNA, complete cds1,027 bp linear mRNADQ366341.1 GI:86753793237. Influenza A virus (A / duck / Guangxi / 22 / 2001(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585514.1 GI:47156246238. Influenza A virus (A / duck / Guangxi / 22 / 2001(H5N1)) matrix protein mRNA, partial cds757 bp linear mRNAAY585388.1 GI:47156330239. Influenza A virus (A / duck / Guangxi / 22 / 2001(H5N1)) neuraminidase (NA) mRNA, complete cds1,414 bp linear mRNAAY585409.1 GI:47156372240. Influenza A virus (A / duck / Guangxi / 22 / 2001(H5N1)) nucleoprotein (NP) mRNA, complete cds1,498 bp linear mRNAAY585430.1 GI:47156414241. Influenza A virus (A / duck / Guangxi / 22 / 2001(H5N1)) nonstructural protein 1 (NS1) mRNA, complete cds687 bp linear mRNAAY585451.1 GI:47156456242. Influenza A virus (A / duck / Guangxi / 35 / 2001(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585515.1 GI:47156248243. Influenza A virus (A / duck / Guangxi / 35 / 2001(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585389.1 GI:47156332244. Influenza A virus (A / duck / Guangxi / 35 / 2001(H5N1)) neuraminidase (NA) mRNA, complete cds1,414 bp linear mRNAAY585410.1 GI:47156374245. Influenza A virus (A / duck / Guangxi / 35 / 2001(H5N1)) nucleoprotein (NP) mRNA, complete cds1,498 bp linear mRNAAY585431.1 GI:47156416246. Influenza A virus (A / duck / Guangxi / 35 / 2001(H5N1)) nonstructural protein 1 (NS1) mRNA, complete cds685 bp linear mRNAAY585452.1 GI:47156458247. Influenza A virus (A / duck / Guangxi / 50 / 2001(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585516.1 GI:47156250248. Influenza A virus (A / duck / Guangxi / 50 / 2001(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585398.1 GI:47156350249. Influenza A virus (A / duck / Guangxi / 50 / 2001(H5N1)) neuraminidase (NA) mRNA, complete cds1,354 bp linear mRNAAY585411.1 GI:47156376250. Influenza A virus (A / duck / Guangxi / 50 / 2001(H5N1)) nucleoprotein (NP) mRNA, complete cds1,498 bp linear mRNAAY585432.1 GI:47156418251. Influenza A virus (A / duck / Guangxi / 50 / 2001(H5N1)) nonstructural protein 1 (NS1) mRNA, complete cds686 bp linear mRNAAY585453.1 GI:47156460252. Influenza A virus (A / duck / Guangxi / 53 / 2002(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585517.1 GI:47156252253. Influenza A virus (A / duck / Guangxi / 53 / 2002(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585390.1 GI:47156334254. Influenza A virus (A / duck / Guangxi / 53 / 2002(H5N1)) neuraminidase (NA) mRNA, complete cds1,361 bp linear mRNAAY585412.1 GI:47156378255. Influenza A virus (A / duck / Guangxi / 53 / 2002(H5N1)) nucleoprotein (NP) mRNA, complete cds1,498 bp linear mRNAAY585433.1 GI:47156420256. Influenza A virus (A / duck / Guangxi / 53 / 2002(H5N1)) nonstructural protein 1 (NS1) mRNA, partial cds687 bp linear mRNAAY585454.1 GI:47156462257. Influenza A virus (A / duck / Kurgan / 08 / 2005(H5N1)) hemagglutinin (HA) mRNA, complete cds1,754 bp linear mRNADQ449640.1 GI:90289674258. Influenza A virus (A / duck / Kurgan / 08 / 2005(H5N1)) matrix protein 1 (M) mRNA, complete cds1,002 bp linear mRNADQ449641.1 GI:90289689259. Influenza A virus (A / duck / Kurgan / 08 / 2005(H5N1)) neuraminidase (NA) mRNA, complete cds1,373 bp linear mRNADQ449642.1 GI:90289708260. Influenza A virus (A / duck / Kurgan / 08 / 2005(H5N1)) nucleoprotein (NP) mRNA, complete cds1,540 bp linear mRNADQ449643.1 GI:90289731261. Influenza A virus (A / duck / Kurgan / 08 / 2005(H5N1)) nonstructural protein (NS) mRNA, complete cds850 bp linear mRNADQ449644.1 GI:90289739262. Influenza A virus (A / duck / Kurgan / 08 / 2005(H5N1)) polymerase acidic protein (PA) mRNA, complete cds2,208 bp linear mRNADQ449645.1 GI:90289756263. Influenza A virus (A / duck / Kurgan / 08 / 2005(H5N1)) polymerase basic protein 1 (PB1) mRNA, complete cds2,316 bp linear mRNADQ449646.1 GI:90289774264. Influenza A virus (A / duck / Kurgan / 08 / 2005(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,316 bp linear mRNADQ449647.1 GI:90289783266. Influenza A virus (A / duck / Shanghai / 08 / 2001(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585518.1 GI:47156254267. Influenza A virus (A / duck / Shanghai / 08 / 2001(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585391.1 GI:47156336268. Influenza A virus (A / duck / Shanghai / 08 / 2001(H5N1)) neuraminidase (NA) mRNA, complete cds1,357 bp linear mRNAAY585413.1 GI:47156380269. Influenza A virus (A / duck / Shanghai / 08 / 2001(H5N1)) nucleoprotein (NP) mRNA, complete cds1,498 bp linear mRNAAY585434.1 GI:47156422270. Influenza A virus (A / duck / Shanghai / 08 / 2001(H5N1)) nonstructural protein 1 (NS1) mRNA, partial cds685 bp linear mRNAAY585455.1 GI:47156464271. Influenza A virus (A / duck / Shanghai / 13 / 2001(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585519.1 GI:47156256272. Influenza A virus (A / duck / Shanghai / 13 / 2001(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585392.1 GI:47156338273. Influenza A virus (A / duck / Shanghai / 13 / 2001(H5N1)) neuraminidase (NA) mRNA, complete cds1,417 bp linear mRNAAY585414.1 GI:47156382274. Influenza A virus (A / duck / Shanghai / 13 / 2001(H5N1)) nucleoprotein (NP) mRNA, complete cds1,499 bp linear mRNAAY585435.1 GI:47156424275. Influenza A virus (A / duck / Shanghai / 13 / 2001(H5N1)) nonstructural protein 1 (NS1) mRNA, complete cds685 bp linear mRNAAY585456.1 GI:47156466276. Influenza A virus (A / duck / Shanghai / 35 / 2002(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585520.1 GI:47156258277. Influenza A virus (A / duck / Shanghai / 35 / 2002(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585393.1 GI:47156340278. Influenza A virus (A / duck / Shanghai / 35 / 2002(H5N1)) neuraminidase (NA) mRNA, complete cds1,363 bp linear mRNAAY585415.1 GI:47156384279. Influenza A virus (A / duck / Shanghai / 35 / 2002(H5N1)) nucleoprotein (NP) mRNA, complete cds1,498 bp linear mRNAAY585436.1 GI:47156426280. Influenza A virus (A / duck / Shanghai / 35 / 2002(H5N1)) nonstructural protein 1 (NS1) mRNA, partial cds685 bp linear mRNAAY585457.1 GI:47156468281. Influenza A virus (A / duck / Shanghai / 37 / 2002(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585521.1 GI:47156260282. Influenza A virus (A / duck / Shanghai / 37 / 2002(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585394.1 GI:47156342283. Influenza A virus (A / duck / Shanghai / 37 / 2002(H5N1)) neuraminidase (NA) mRNA, complete cds1,361 bp linear mRNAAY585416.1 GI:47156386284. Influenza A virus (A / duck / Shanghai / 37 / 2002(H5N1)) nucleoprotein (NP) mRNA, complete cds1,497 bp linear mRNAAY585437.1 GI:47156428285. Influenza A virus (A / duck / Shanghai / 37 / 2002(H5N1)) nonstructural protein 1 (NS1) mRNA, partial cds685 bp linear mRNAAY585458.1 GI:47156470286. Influenza A virus (A / duck / Shanghai / 38 / 2001(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,282 bp linear mRNAAY585522.1 GI:47156262287. Influenza A virus (A / duck / Shanghai / 38 / 2001(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585395.1 GI:47156344288. Influenza A virus (A / duck / Shanghai / 38 / 2001(H5N1)) neuraminidase (NA) mRNA, complete cds1,355 bp linear mRNAAY585417.1 GI:47156388289. Influenza A virus (A / duck / Shanghai / 38 / 2001(H5N1)) nucleoprotein (NP) mRNA, complete cds1,499 bp linear mRNAAY585438.1 GI:47156430290. Influenza A virus (A / duck / Shanghai / 38 / 2001(H5N1)) nonstructural protein 1 (NS1) mRNA, partial cds692 bp linear mRNAAY585459.1 GI:47156472291. Influenza A virus (A / duck / Sheyang / 1 / 2005(H5N1)) nonstructural protein (NS) mRNA, complete cds875 bp linear mRNADQ354059.1 GI:87128643292. Influenza A virus (A / duck / Tuva / 01 / 2006(H5N1)) hemagglutinin (HA) mRNA, complete cds1,748 bp linear mRNADQ861291.1 GI:112820195293. Influenza A virus (A / duck / Tuva / 01 / 2006(H5N1)) matrix protein 1 (M1) mRNA, complete cds991 bp linear mRNADQ861292.1 GI:112820197294. Influenza A virus (A / duck / Tuva / 01 / 2006(H5N1)) neuraminidase (NA) mRNA, complete cds1,364 bp linear mRNADQ861293.1 GI:112820199295. Influenza A virus (A / duck / Tuva / 01 / 2006(H5N1)) nucleoprotein (NP) mRNA, complete cds1,531 bp linear mRNADQ861294.1 GI:112820201296. Influenza A virus (A / duck / Tuva / 01 / 2006(H5N1)) nonstructural protein (NS) mRNA, complete cds842 bp linear mRNADQ861295.1 GI:112820203297. Influenza A virus (A / duck / Vietnam / 1 / 2005(H5N1)) nonstructural protein 1 mRNA, complete cds890 bp linear mRNADQ366310.1 GI:86753715298. Influenza A virus (A / duck / Vietnam / 1 / 2005(H5N1)) polymerase PB2 mRNA, complete cds2,341 bp linear mRNADQ366303.1 GI:86753725299. Influenza A virus (A / duck / Vietnam / 1 / 2005(H5N1)) polymerase PB1 mRNA, complete cds2,341 bp linear mRNADQ366304.1 GI:86753735300. Influenza A virus (A / duck / Vietnam / 1 / 2005(H5N1)) PA protein mRNA, complete cds2,233 bp linear mRNADQ366305.1 GI:86753745301. Influenza A virus (A / duck / Vietnam / 1 / 2005(H5N1)) hemagglutinin mRNA, complete cds1,779 bp linear mRNADQ366306.1 GI:86753755302. Influenza A virus (A / duck / Vietnam / 1 / 2005(H5N1)) nucleocapsid mRNA, complete cds1,565 bp linear mRNADQ366307.1 GI:86753765303. Influenza A virus (A / duck / Vietnam / 1 / 2005(H5N1)) neuraminidase mRNA, complete cds1,401 bp linear mRNADQ366308.1 GI:86753775304. Influenza A virus (A / duck / Vietnam / 1 / 2005(H5N1)) matrix protein mRNA, complete cds1,027 bp linear mRNADQ366309.1 GI:86753785305. Influenza A virus (A / duck / Vietnam / 8 / 05(H5N1)) nonstructural protein 1 mRNA, complete cds890 bp linear mRNADQ366326.1 GI:86753719306. Influenza A virus (A / duck / Vietnam / 8 / 05(H5N1)) polymerase PB2 mRNA, complete cds2,341 bp linear mRNADQ366319.1 GI:86753729307. Influenza A virus (A / duck / Vietnam / 8 / 05(H5N1)) polymerase PB1 mRNA, complete cds2,341 bp linear mRNADQ366320.1 GI:86753739308. Influenza A virus (A / duck / Vietnam / 8 / 05(H5N1)) PA protein mRNA, complete cds2,233 bp linear mRNADQ366321.1 GI:86753749309. Influenza A virus (A / duck / Vietnam / 8 / 05(H5N1)) hemagglutinin mRNA, complete cds1,779 bp linear mRNADQ366322.1 GI:86753759310. Influenza A virus (A / duck / Vietnam / 8 / 05(H5N1)) nucleocapsid mRNA, complete cds1,565 bp linear mRNADQ366323.1 GI:86753769311. Influenza A virus (A / duck / Vietnam / 8 / 05(H5N1)) neuraminidase mRNA, complete cds1,401 bp linear mRNADQ366324.1 GI:86753779312. Influenza A virus (A / duck / Vietnam / 8 / 05(H5N1)) matrix protein mRNA, complete cds1,027 bp linear mRNADQ366325.1 GI:86753789313. Influenza A virus (A / duck / Yangzhou / 232 / 2004(H5N1)) nonfunctional nonstructural protein (NS) mRNA, complete sequence876 bp linear mRNADQ354060.1 GI:87128645314. Influenza A virus (A / duck / Zhejiang / 11 / 2000(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585523.1 GI:47156264315. Influenza A virus (A / duck / Zhejiang / 11 / 2000(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585396.1 GI:47156346316. Influenza A virus (A / duck / Zhejiang / 11 / 2000(H5N1)) neuraminidase (NA) mRNA, complete cds1,352 bp linear mRNAAY585418.1 GI:47156390317. Influenza A virus (A / duck / Zhejiang / 11 / 2000(H5N1)) nucleoprotein (NP) mRNA, complete cds1,498 bp linear mRNAAY585439.1 GI:47156432318. Influenza A virus (A / duck / Zhejiang / 11 / 2000(H5N1)) nonstructural protein 1 (NS1) mRNA, partial cds687 bp linear mRNAAY585460.1 GI:47156474319. Influenza A virus (A / duck / Zhejiang / 52 / 2000(H5N1)) polymerase basic protein 2 (PB2) mRNA, complete cds2,281 bp linear mRNAAY585524.1 GI:47156266320. Influenza A virus (A / duck / Zhejiang / 52 / 2000(H5N1)) matrix protein mRNA, complete cds760 bp linear mRNAAY585397.1 GI:47156348321. Influenza A virus (A / duck / Zhejiang / 52 / 2000(H5N1)) neuraminidase (NA) mRNA, complete cds1,423 bp linear mRNAAY585419.1 GI:47156392322. Influenza A virus (A / duck / Zhejiang / 52 / 2000(H5N1)) nucleoprotein (NP) mRNA, complete cds1,499 bp linear mRNAAY585440.1 GI:47156434323. Influenza A virus (A / duck / Zhejiang / 52 / 2000(H5N1)) nonstructural protein 1 (NS1) mRNA, complete cds686 bp linear mRNAAY585461.1 GI:47156476324. Influenza A virus (A / Egypt / 0636-NAMRU3 / 2007(H5N1)) hemagglutinin (HA) mRNA, complete cds1,749 bp linear mRNAEF382359.1 GI:124244205325. Influenza A virus (A / goosander / Switzerland / V82 / 06 (H5N1)) hemagglutinin (HA) gene, complete cds1,707 bp linear mRNAEF110518.1 GI:119394674326. Influenza A virus (A / goose / Guangdong / 1 / 96 / (H5N1)) hemagglutinin mRNA, complete cds1,707 bp linear mRNAAF148678.1 GI:5007022327. Influenza A virus (A / Goose / Huadong / 1 / 2000(H5N1)) hemagglutinin (HA) mRNA, complete cds1,779 bp linear mRNADQ201829.1 GI:76786306328. Influenza A virus (A / Goose / Huadong / 1 / 2000(H5N1)) neuraminidase (NA) mRNA, complete cds1,458 bp linear mRNADQ201830.1 GI:76786308329. Influenza A virus (A / goose / Hungary / 2823 / 2 / 2007(H5N1)) polymerase PB1 (PB1) mRNA, partial cds2,287 bp linear mRNAEF446768.1 GI:126428373330. Influenza A virus (A / goose / Hungary / 2823 / 2 / 2007(H5N1)) polymerase PB2 (PB2) mRNA, partial cds2,274 bp linear mRNAEF446769.1 GI:126428375331. Influenza A virus (A / goose / Hungary / 2823 / 2 / 2007(H5N1)) polymerase PA (PA) mRNA, complete cds2,175 bp linear mRNAEF446770.1 GI:126428377332. Influenza A virus (A / goose / Hungary / 2823 / 2 / 2007(H5N1)) hemagglutinin (HA) mRNA, complete cds1,735 bp linear mRNAEF446771.1 GI:126428379333. Influenza A virus (A / goose / Hungary / 2823 / 2 / 2007(H5N1)) nucleocapsid protein (NP) mRNA, partial cds1,473 bp linear mRNAEF446772.1 GI:126428381334. Influenza A virus (A / goose / Hungary / 2823 / 2 / 2007(H5N1)) neuraminidase (NA) mRNA, partial cds1,311 bp linear mRNAEF446773.1 GI:126428383335. Influenza A virus (A / goose / Hungary / 2823 / 2 / 2007(H5N1)) matrix protein 1 (M1) mRNA, partial cds971 bp linear mRNAEF446774.1 GI:126428385336. Influenza A virus (A / goose / Hungary / 2823 / 2 / 2007(H5N1)) nonstructural protein 1 (NS1) mRNA, partial cds795 bp linear mRNAEF446775.1 GI:126428387337. Influenza A virus (A / goose / Hungary / 3413 / 2007(H5N1)) polymerase PB1 (PB1) mRNA, partial cds2,277 bp linear mRNAEF446776.1 GI:126428389338. Influenza A virus (A / goose / Hungary / 3413 / 2007(H5N1)) polymerase PB2 (PB2) mRNA, partial cds2,274 bp linear mRNAEF446777.1 GI:126428391339. Influenza A virus (A / goose / Hungary / 3413 / 2007(H5N1)) polymerase PA (PA) mRNA, partial cds2,163 bp linear mRNAEF446778.1 GI:126428393340. Influenza A virus (A / goose / Hungary / 3413 / 2007(H5N1)) hemagglutinin (HA) mRNA, complete cds1,722 bp linear mRNAEF446779.1 GI:126428395341. Influenza A virus (A / goose / Hungary / 3413 / 2007(H5N1)) nucleocapsid protein (NP) mRNA, partial cds1,463 bp linear mRNAEF446780.1 GI:126428397342. Influenza A virus (A / goose / Hungary / 3413 / 2007(H5N1)) neuraminidase (NA) mRNA, partial cds1,289 bp linear mRNAEF446781.1 GI:126428399343. Influenza A virus (A / goose / Hungary / 3413 / 2007(H5N1)) matrix protein 1 (M1) mRNA, partial cds955 bp linear mRNAEF446782.1 GI:126428401344. Influenza A virus (A / goose / Hungary / 3413 / 2007(H5N1)) nonstructural protein 1 (NS1) mRNA, complete cds805 bp linear mRNAEF446783.1 GI:126428403345. Influenza A virus (A / goose / jiangsu / 131 / 2002(H5N1)) nonfunctional nonstructural protein (NS) mRNA, complete sequence877 bp linear mRNADQ354061.1 GI:87128646346. Influenza A virus (A / goose / Jiangsu / 220 / 2003(H5N1)) nonstructural protein (NS) mRNA, complete cds875 bp linear mRNADQ354062.1 GI:87128647347. Influenza A virus (A / goose / Krasnoozerka / 627 / 2005(H5N1)) hemagglutinin (HA) mRNA, complete cds1,754 bp linear mRNADQ676840.1 GI:108782531348. Influenza A virus (A / goose / Krasnoozerka / 627 / 2005(H5N1)) nucleoprotein (NP) mRNA, complete cds1,530 bp linear mRNADQ676841.1 GI:108782533349. Influenza A virus (A / goose / Krasnoozerka / 627 / 2005(H5N1)) nonstructural protein (NS) mRNA, complete cds850 bp linear mRNADQ676842.1 GI:108782535350. Influenza A virus (A / goose / Vietnam / 3 / 05(H5N1)) nonstructural protein 1 mRNA, complete cds890 bp linear mRNADQ366318.1 GI:86753717351. Influenza A virus (A / goose / Vietnam / 3 / 05(H5N1)) polymerase PB2 mRNA, complete cds2,341 bp linear mRNADQ366311.1 GI:86753727352. Influenza A virus (A / goose / Vietnam / 3 / 05(H5N1)) polymerase PB1 mRNA, complete cds2,341 bp linear mRNADQ366312.1 GI:86753737353. Influenza A virus (A / goose / Vietnam / 3 / 05(H5N1)) PA protein mRNA, complete cds2,233 bp linear mRNADQ366313.1 GI:86753747354. Influenza A virus (A / goose / Vietnam / 3 / 05(H5N1)) hemagglutinin mRNA, complete cds1,779 bp linear mRNADQ366314.1 GI:86753757355. Influenza A virus (A / goose / Vietnam / 3 / 05(H5N1)) nucleocapsid mRNA, complete cds1,565 bp linear mRNADQ366315.1 GI:86753767356. Influenza A virus (A / goose / Vietnam / 3 / 05(H5N1)) neuraminidase mRNA, complete cds1,401 bp linear mRNADQ366316.1 GI:86753777357. Influenza A virus (A / goose / Vietnam / 3 / 05(H5N1)) matrix protein mRNA, complete cds1,027 bp linear mRNADQ366317.1 GI:86753787358. Influenza A virus (A / gull / Pennsylvania / 4175 / 83(H5N1)) hemagglutinin H5 mRNA, partial cds1,700 bp linear mRNAAF082043.1 GI:4240453360. Influenza A virus (A / HongKong / 156 / 97(H5N1)) neuraminidase mRNA, complete cds1,388 bp linear mRNAAF028708.1 GI:2865377361. Influenza A virus (A / HongKong / 156 / 97(H5N1)) hemagglutinin mRNA, complete cds1,741 bp linear mRNAAF028709.1 GI:2865379362. Influenza A virus (A / HongKong / 156 / 97(H5N1)) nucleoprotein mRNA, complete cds1,549 bp linear mRNAAF028710.1 GI:2865381363. Influenza A virus (A / hooded vulture / Burkina Faso / 1 / 2006(H5N1)) partial mRNA for nucleoprotein (np gene)1,451 bp linear mRNAAM503028.1 GI:147846292364. Influenza A virus (A / hooded vulture / Burkina Faso / 1 / 2006(H5N1)) mRNA for non-structural protein (ns gene)827 bp linear mRNAAM503038.1 GI:147846312365. Influenza A virus (A / hooded vulture / Burkina Faso / 1 / 2006(H5N1)) partial mRNA for polymerase (pa gene)2,169 bp linear mRNAAM503047.1 GI:147846330366. Influenza A virus (A / hooded vulture / Burkina Faso / 1 / 2006(H5N1)) partial mRNA for polymerase basic protein 1 (pb1 gene)1,686 bp linear mRNAAM503065.1 GI:147846855367. Influenza A virus (A / hooded vulture / Burkina Faso / 2 / 2006(H5N1)) partial mRNA for matrix protein 1 (m1 gene)977 bp linear mRNAAM503006.1 GI:147846248368. Influenza A virus (A / hooded vulture / Burkina Faso / 2 / 2006(H5N1)) partial mRNA for neuraminidase (na gene)1,336 bp linear mRNAAM503017.1 GI:147846270369. Influenza A virus (A / hooded vulture / Burkina Faso / 2 / 2006(H5N1)) partial mRNA for nucleoprotein (np gene)1,499 bp linear mRNAAM503027.1 GI:147846290370. Influenza A virus (A / hooded vulture / Burkina Faso / 2 / 2006(H5N1)) mRNA for non-structural protein (ns gene)827 bp linear mRNAAM503039.1 GI:147846314371. Influenza A virus (A / hooded vulture / Burkina Faso / 2 / 2006(H5N1)) partial mRNA for polymerase (pa gene)2,169 bp linear mRNAAM503048.1 GI:147846332372. Influenza A virus (A / hooded vulture / Burkina Faso / 2 / 2006(H5N1)) partial mRNA for polymerase basic protein 1 (pb1 gene)2,259 bp linear mRNAAM503062.1 GI:147846849373. Influenza A virus (A / hooded vulture / Burkina Faso / 2 / 2006(H5N1)) partial mRNA for polymerase basic protein 2 (pb2 gene)2,315 bp linear mRNAAM503066.1 GI:147846857374. Influenza A virus (A / Indonesia / CDC177 / 2005(H5N1)) M2 protein mRNA, complete cds294 bp linear mRNAEU014135.1 GI:151336850375. Influenza A virus (A / Indonesia / CDC298 / 2005(H5N1)) M2 protein mRNA, complete cds294 bp linear mRNAEU014138.1 GI:151336856376. Influenza A virus (A / Indonesia / CDC485 / 2006(H5N1)) M2 protein mRNA, complete cds294 bp linear mRNAEU014136.1 GI:151336852377. Influenza A virus (A / Indonesia / CDC530 / 2006(H5N1)) M2 protein mRNA, complete cds294 bp linear mRNAEU014134.1 GI:151336848378. Influenza A virus (A / Indonesia / CDC535 / 2006(H5N1)) M2 protein mRNA, complete cds294 bp linear mRNAEU014133.1 GI:151336846379. Influenza A virus (A / Indonesia / CDC540 / 2006(H5N1)) M2 protein mRNA, complete cds294 bp linear mRNAEU014132.1 GI:151336844380. Influenza A virus (A / Indonesia / CDC561 / 2006(H5N1)) M2 protein mRNA, complete cds294 bp linear mRNAEU014137.1 GI:151336854381. Influenza A virus (A / Indonesia / CDC60 / 2005(H5N1)) M2 protein mRNA, complete cds294 bp linear mRNAEU014139.1 GI:151336858382. Influenza A virus (A / mallard / Wisconsin / 428 / 75(H5N1)) hemagglutinin mRNA, partial cds996 bp linear mRNAU79453.1 GI:1840071383. Influenza A virus (A / ostrich / VRLCU / Egypt / 2011(H5N1)) segment 4 hemagglutinin (HA) mRNA, partial cds441 bp linear mRNAJN157759.1 GI:338223304384. Influenza A virus (A / quail / yunnan / 092 / 2002(H5N1)) nonstructural protein (NS) mRNA, complete cds875 bp linear mRNADQ354063.1 GI:87128649385. Influenza A virus (A / R(Turkey / Ontario / 7732 / 66-Bellamy / 42)(H5N1)) HA mRNA for hemagglutinin, partial cds1,472 bp linear mRNAAB241613.1 GI:82581222386. Influenza A virus (A / Thailand / LFPN-2004 / 2004(H5N1)) neuraminidase mRNA, complete cds1,350 bp linear mRNAAY679513.1 GI:50843945387. Influenza A virus (A / Thailand / LFPN-2004 / 2004(H5N1)) hemagglutinin mRNA, complete cds1,704 bp linear mRNAAY679514.1 GI:50843949388. Influenza A virus (A / tiger / Thailand / CU-T4 / 04(H5N1)) polymerase basic protein 2 (PB2) mRNA, partial cds534 bp linear mRNADQ017251.1 GI:65329524389. Influenza A virus (A / tiger / Thailand / CU-T5 / 04(H5N1)) polymerase basic protein 2 (PB2) mRNA, partial cds582 bp linear mRNADQ017252.1 GI:65329536390. Influenza A virus (A / tiger / Thailand / CU-T6 / 04(H5N1)) polymerase basic protein 2 (PB2) mRNA, partial cds564 bp linear mRNADQ017253.1 GI:65329553391. Influenza A virus (A / tiger / Thailand / CU-T8 / 04(H5N1)) polymerase basic protein 2 (PB2) mRNA, partial cds582 bp linear mRNADQ017254.1 GI:65329568392. Influenza A virus (A / turkey / England / 250 / 2007(H5N1)) hemagglutinin (HA) mRNA, partial cds1,695 bp linear mRNAEF441263.1 GI:129307104393. Influenza A virus (A / turkey / England / 250 / 2007(H5N1)) matrix protein (M) mRNA, partial cds943 bp linear mRNAEF441264.1 GI:129307106394. Influenza A virus (A / turkey / England / 250 / 2007(H5N1)) nonstructural protein 1 (NS1) mRNA, complete cds812 bp linear mRNAEF441265.1 GI:129307109395. Influenza A virus (A / turkey / England / 250 / 2007(H5N1)) polymerase PA (PA) mRNA, complete cds2,185 bp linear mRNAEF441266.1 GI:129307111396. Influenza A virus (A / turkey / England / 250 / 2007(H5N1)) polymerase PB2 (PB2) mRNA, partial cds2,272 bp linear mRNAEF441267.1 GI:129307113397. Influenza A virus (A / turkey / England / 250 / 2007(H5N1)) nucleocapsid (NP) mRNA, partial cds1,396 bp linear mRNAEF441268.1 GI:129307115398. Influenza A virus (A / turkey / England / 250 / 2007(H5N1)) polymerase PB1 (PB1) mRNA, partial cds2,288 bp linear mRNAEF441269.1 GI:129307117399. Influenza A virus (A / turkey / England / 250 / 2007(H5N1)) neuraminidase (NA) mRNA, partial cds1,276 bp linear mRNAEF441270.1 GI:129307119A / chicken / Burkina Faso / 13.1 / 2006(H5N1) neuraminidase (NA)AM503016.1A / chicken / Crimea / 04 / 2005(H5N1) neuraminidase (NA)DQ650661.1A / chicken / Crimea / 04 / 2005(H5N1) hemagglutininDQ650659.1A / chicken / Crimea / 08 / 2005(H5N1) polymerase basic protein 1 (PB1)DQ650669.1A / chicken / Crimea / 08 / 2005(H5N1) neuraminidase (NA)DQ650665.1A / chicken / Crimea / 08 / 2005(H5N1) hemagglutinin (HA)DQ650663.1A / chicken / Guangxi / 12 / 2004(H5N1) nonstructural protein 1DQ366334.1A / chicken / Guangxi / 12 / 2004(H5N1) neuraminidaseDQ366332.1A / chicken / Guangxi / 12 / 2004(H5N1) hemagglutininDQ366330.1A / duck / Kurgan / 08 / 2005(H5N1) nucleoprotein (NP)DQ449643.1 Table 9. Other Influenza A Antigens (H1N ∗< , H2N ∗< , H3N ∗< ) Strain / Protein Length GenBank / GI Accession Nos. H1N* Influenza A virus (A / duck / Hong Kong / 193 / 1977(H1N2)) nucleoprotein (NP) mRNA, partial cds1,402 bp linear mRNAU49097.1 GI:1912392Influenza A virus (A / duck / Hong Kong / 193 / 1977(H1N2)) polymerase (PB1) mRNA, partial cds258 bp linear mRNAU48285.1 GI:1912374Influenza A virus (A / England / 2 / 2002(H1N2)) partial NS1 gene for non structural protein 1 and partial NS2 gene for non structural protein 2, genomic RNA795 bp linear mRNAAJ519455.1 GI:31096426Influenza A virus (A / England / 3 / 02(H1N2)) partial mRNA for nucleoprotein (np gene)384 bp linear mRNAAJ489497.1 GI:27526856Influenza A virus (A / England / 3 / 02(H1N2)) partial mRNA for polymerase subunit 2 (pb2 gene)442 bp linear mRNAAJ489488.1 GI:27526838Influenza A virus (A / England / 5 / 02(H1N2)) partial mRNA for nucleoprotein (np gene)384 bp linear mRNAAJ489498.1 GI:27526858Influenza A virus (A / England / 5 / 02(H1N2)) partial mRNA for polymerase subunit 2 (pb2 gene)442 bp linear mRNAAJ489489.1 GI:27526840Influenza A virus (A / England / 57 / 02(H1N2)) partial mRNA for nucleoprotein (np gene)384 bp linear mRNAAJ489499.1 GI:27526860Influenza A virus (A / England / 57 / 02(H1N2)) partial mRNA for polymerase subunit 2 (pb2 gene)442 bp linear mRNAAJ489492.1 GI:27526846Influenza A virus (A / England / 691 / 01(H1N2)) partial mRNA for nucleoprotein (np gene)384 bp linear mRNAAJ489496.1 GI:27526854Influenza A virus (A / England / 73 / 02(H1N2)) partial mRNA for nucleoprotein (np gene)384 bp linear mRNAAJ489500.1 GI:27526862Influenza A virus (A / England / 73 / 02(H1N2)) partial mRNA for polymerase subunit 2 (pb2 gene)442 bp linear mRNAAJ489493.1 GI:27526848Influenza A virus (A / England / 90 / 02(H1N2)) partial mRNA for nucleoprotein (np gene)384 bp linear mRNAAJ489501.1 GI:27526864Influenza A virus (A / England / 90 / 02(H1N2)) partial mRNA for polymerase subunit 2 (pb2 gene)442 bp linear mRNAAJ489490.1 GI:27526842Influenza A virus (A / England / 97 / 02(H1N2)) partial mRNA for nucleoprotein (np gene)384 bp linear mRNAAJ489502.1 GI:27526866Influenza A virus (A / England / 97 / 02(H1N2)) partial mRNA for polymerase subunit 2 (pb2 gene)442 bp linear mRNAAJ489491.1 GI:27526844Influenza A virus (A / England / 627 / 01(H1N2)) partial mRNA for nucleoprotein (np gene)384 bp linear mRNAAJ489494.1 GI:27526850Influenza A virus (A / England / 627 / 01(H1N2)) partial mRNA for polymerase subunit 2 (pb2 gene)442 bp linear mRNAAJ489485.1 GI:27526832Influenza A virus (A / England / 691 / 01(H1N2)) partial mRNA for polymerase subunit 2 (pb2 gene)442 bp linear mRNAAJ489487.1 GI:27526836Influenza A virus (A / Egypt / 96 / 2002(H1N2)) partial NS1 gene for non structural protein 1 and partial NS2 gene for non structural protein 2, genomic RNA747 bp linear mRNAAJ519457.1 GI:31096432Influenza A virus (A / Israel / 6 / 2002(H1N2)) partial NS1 gene for non structural protein 1 and partial NS2 gene for non structural protein 2, genomic RNA773 bp linear mRNAAJ519456.1 GI:31096429Influenza A virus (A / Saudi Arabia / 2231 / 2001(H1N2)) partial NS1 gene for non structural protein 1 and partial NS2 gene for non structural protein 2, genomic RNA772 bp linear mRNAAJ519453.1 GI:31096420Influenza A virus (A / Scotland / 122 / 01(H1N2)) partial mRNA for nucleoprotein (np gene)384 bp linear mRNAAJ489495.1 GI:27526852Influenza A virus (A / Scotland / 122 / 01(H1N2)) partial mRNA for polymerase subunit 2 (pb2 gene)442 bp linear mRNAAJ489486.1 GI:27526834Influenza A virus (A / swine / Bakum / 1832 / 2000(H1N2)) hemagglutinin (HA) mRNA, partial cds832 bp linear mRNAAY861443.1 GI:57791765Influenza A virus (A / swine / Bakum / 1832 / 2000(H1N2)) neuraminidase mRNA, partial cds467 bp linear mRNAAY870645.1 GI:58042754Influenza A virus (A / swine / Cotes d'Armor / 0040 / 2007(H1N2)) segment 4 partial mRNA1,039 bp linear mRNAAM503547.1 GI:225578611Influenza A virus (A / swine / Cotes d'Armor / 0136_17 / 2006(H1N2)) partial mRNA for haemagglutinin precursor (HA1 gene)1,136 bp linear mRNAAM490224.3 GI:222062921Influenza A virus (A / swine / England / 72685 / 96(H1N2)) haemagglutinin precursor, mRNA, complete cds1,778 bp linear mRNAAF085417.1 GI:3831770Influenza A virus (A / swine / England / 17394 / 96(H1N2)) haemagglutinin precursor, mRNA, complete cds1,778 bp linear mRNAAF085416.1 GI:3831768Influenza A virus (A / swine / England / 690421 / 95(H1N2)) haemagglutinin precursor, mRNA, complete cds1,778 bp linear mRNAAF085415.1 GI:3831766Influenza A virus (A / swine / England / 438207 / 94(H1N2)) haemagglutinin precursor, mRNA, complete cds1,778 bp linear mRNAAF085414.1 GI:3831764Influenza A virus (A / Swine / Korea / CY02 / 02(H1N2)) neuraminidase (NA) mRNA, complete cds1,427 bp linear mRNAAY129157.1 GI:24286064Influenza A virus (A / Swine / Korea / CY02 / 02(H1N2)) matrix protein (M) mRNA, complete cds952 bp linear mRNAAY129158.1 GI:24286066Influenza A virus (A / Swine / Korea / CY02 / 02(H1N2)) nucleoprotein (NP) mRNA, complete cds1,542 bp linear mRNAAY129159.1 GI:24286069Influenza A virus (A / Swine / Korea / CY02 / 02(H1N2)) nonstructural protein (NS) mRNA, complete cds842 bp linear mRNAAY129160.1 GI:24286081Influenza A virus (A / Swine / Korea / CY02 / 02(H1N2)) polymerase acidic protein 2 (PA) mRNA, complete cds2,165 bp linear mRNAAY129161.1 GI:24286087Influenza A virus (A / Swine / Korea / CY02 / 02(H1N2)) polymerase subunit 1 (PB1) mRNA, complete cds2,274 bp linear mRNAAY129162.1 GI:24286096Influenza A virus (A / Swine / Korea / CY02 / 02(H1N2)) polymerase subunit 2 (PB2) mRNA, complete cds2,334 bp linear mRNAAY129163.1 GI:24286100Influenza A virus (A / swine / Scotland / 410440 / 94(H1N2)) haemagglutinin precursor, mRNA, complete cds1,778 bp linear mRNAAF085413.1 GI:3831762Influenza A virus (A / swine / Spain / 80598-LP4 / 2007(H1N2)) matrix protein 2 (M2) mRNA, partial cds291 bp linear mRNAEU305436.1 GI:168830657Influenza A virus (A / Switzerland / 3100 / 2002(H1N2)) partial HA gene for Haemagglutinin, genomic RNA975 bp linear mRNAAJ517813.1 GI:38422519Influenza A virus (A / duck / Hong Kong / 717 / 1979(H1N3)) nucleoprotein (NP) mRNA, partial cds1,387 bp linear mRNAU49095.1 GI:1912388Influenza A virus (A / duck / Hong Kong / 717 / 1979(H1N3)) polymerase (PB1) mRNA, partial cds265 bp linear mRNAU48281.1 GI:1912366Influenza A virus (A / herring gull / New Jersey / 780 / 86 (H1N3)) nonfunctional matrix protein mRNA, partial sequence971 bp linear mRNAAY664422.1 GI:51011826Influenza A virus (A / mallard / Alberta / 42 / 77(H1N6)) nonfunctional matrix protein mRNA, partial sequence997 bp linear mRNAAY664426.1 GI:51011830Influenza A virus (A / swine / England / 191973 / 92(H1N7)) matrix protein M1 mRNA, complete cds1,020 bp linear mRNAU85985.1 GI:1835733Influenza A virus (A / swine / England / 191973 / 92(H1N7)) nucleoprotein mRNA, complete cds1,524 bp linear mRNAU85987.1 GI:1835737Influenza A virus (A / swine / England / 191973 / 92(H1N7)) neuraminidase mRNA, complete cds1,458 bp linear mRNAU85988.1 GI:1835739Influenza A virus (A / swine / England / 191973 / 92(H1N7)) haemagglutinin HA mRNA, partial cds1,698 bp linear mRNAU85986.1 GI:1835735 H2N* Influenza A virus (A / ruddy turnstone / Delaware / 81 / 93 (H2N1)) nonfunctional matrix protein mRNA, partial sequence917 bp linear mRNAAY664465.1 GI:51011869Influenza A virus (A / ruddy turnstone / Delaware / 34 / 93 (H2N1)) nonfunctional matrix protein mRNA, partial sequence968 bp linear mRNAAY664429.1 GI:51011833Influenza A virus (A / Shorebird / Delaware / 122 / 97(H2N1)) nonfunctional matrix protein mRNA, partial sequence925 bp linear mRNAAY664466.1 GI:51011870Influenza A virus (A / shorebird / Delaware / 138 / 97 (H2N1)) nonfunctional matrix protein mRNA, partial sequence958 bp linear mRNAAY664454.1 GI:51011858Influenza A virus (A / shorebird / Delaware / 111 / 97 (H2N1)) nonfunctional matrix protein mRNA, partial sequence958 bp linear mRNAAY664457.1 GI:51011861Influenza A virus (A / shorebird / Delaware / 24 / 98 (H2N1)) nonfunctional matrix protein mRNA, partial sequence979 bp linear mRNAAY664442.1 GI:51011846Influenza virus type A / Leningrad / 134 / 17 / 57 (H2N2) PA RNA, complete cds2,233 bp linear mRNAM81579.1 GI:324935Influenza A virus (STRAIN A / MALLARD / NEW YORK / 6750 / 78) partial mRNA for PA protein2,151 bp linear mRNAAJ243994.1 GI:5918195Influenza A virus (A / X-7(F1) / (H2N2)) neuraminidase mRNA, complete cds1,467 bp linear mRNAM11205.1 GI:323969Influenza A virus (A / mallard / Alberta / 77 / 77 (H2N3)) nonfunctional matrix protein mRNA, partial sequence1,009 bp linear mRNAAY664425.1 GI:51011829Influenza A virus (A / mallard / Alberta / 226 / 98(H2N3)) nonfunctional matrix protein mRNA, partial sequence968 bp linear mRNAAY664447.1 GI:51011851Influenza A virus (A / sanderling / New Jersey / 766 / 86 (H2N7)) nonfunctional matrix protein mRNA, partial sequence846 bp linear mRNAAY664477.1 GI:51011881Influenza A virus (A / laughing gull / New Jersey / 798 / 86 (H2N7)) nonfunctional matrix protein mRNA, partial sequence907 bp linear mRNAAY664471.1 GI:51011875Influenza A virus (A / herring gull / Delaware / 471 / 1986(H2N7)) nonfunctional matrix protein mRNA, partial sequence960 bp linear mRNAAY664440.1 GI:51011844Influenza A virus (A / ruddy turnstone / Delaware / 142 / 98 (H2N8)) nonfunctional matrix protein mRNA, partial sequence1,011 bp linear mRNAAY664423.1 GI:51011827Influenza A virus (A / pintail / Alberta / 293 / 77 (H2N9)) nonfunctional matrix protein mRNA, partial sequence906 bp linear mRNAAY664473.1 GI:51011877Influenza A virus (A / blue-winged teal / Alberta / 16 / 97 (H2N9)) nonfunctional matrix protein mRNA, partial sequence961 bp linear mRNAAY664449.1 GI:51011853Influenza A virus (A / Laughing gull / New Jersey / 75 / 85 (H2N9)) nonfunctional matrix protein mRNA, partial sequence952 bp linear mRNAAY664437.1 GI:51011841Influenza A virus (A / mallard / Alberta / 205 / 98 (H2N9)) nonfunctional matrix protein mRNA, partial sequence959 bp linear mRNAAY664450.1 GI:51011854 H3N* Influenza A virus (A / duck / Eastern China / 267 / 2003(H3N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,458 bp linear mRNAEU429755.1 GI:167859475Influenza A virus (A / duck / Eastern China / 253 / 2003(H3N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,458 bp linear mRNAEU429754.1 GI:167859473Influenza A virus (A / duck / Eastern China / 252 / 2003(H3N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,458 bp linear mRNAEU429753.1 GI:167859471Influenza A virus (A / duck / Eastern China / 243 / 2003(H3N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,458 bp linear mRNAEU429752.1 GI:167859469Influenza A virus (A / duck / Eastern China / 262 / 2003(H3N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,458 bp linear mRNAEU429734.1 GI:167859433Influenza A virus (A / duck / Eastern China / 233 / 2003(H3N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,459 bp linear mRNAEU429733.1 GI:167859431Influenza A virus (A / duck / Eastern China / 213 / 2003(H3N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,458 bp linear mRNAEU429723.1 GI:167859411Influenza A virus (A / duck / Eastern China / 341 / 2003(H3N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,458 bp linear mRNAEU429719.1 GI:167859403Influenza A virus (A / duck / Eastern China / 01 / 2002(H3N1)) segment 6 neuraminidase (NA) mRNA, complete cds1,458 bp linear mRNAEU429718.1 GI:167859401Influenza A virus (A / mallard / Alberta / 22 / 76 (H3N6)) nonfunctional matrix protein mRNA, partial sequence1,013 bp linear mRNAAY664434.1 GI:51011838Influenza A virus (A / mallard / Alberta / 199 / 99(H3N6)) nonfunctional matrix protein mRNA, partial sequence970 bp linear mRNAAY664443.1 GI:51011847Influenza A virus (A / shorebird / Delaware / 222 / 97 (H3N6)) nonfunctional matrix protein mRNA, partial sequence922 bp linear mRNAAY664461.1 GI:51011865Influenza A virus (A / Duck / Hokkaido / 8 / 80 (H3N8)) hemagglutinin precursor, mRNA, partial cds984 bp linear mRNAAF079570.1 GI:3414978Influenza A virus (A / Duck / Hokkaido / 8 / 80 (H3N8)) nucleoprotein mRNA, complete cds1,497 bp linear mRNAAF079571.1 GI:3414980Influenza A virus (A / duck / Ukraine / 1 / 1963(H3N8)) segment 6 neuraminidase (NA) mRNA, complete cds1,461 bp linear mRNAEU429797.1 GI:167859559Influenza A virus (A / duck / Eastern China / 19 / 2004(H3N8)) segment 6 neuraminidase (NA) mRNA, complete cds1,460 bp linear mRNAEU429698.1 GI:167859361Influenza A virus (A / duck / Eastern China / 90 / 2004(H3N8)) segment 6 neuraminidase (NA) mRNA, complete cds1,460 bp linear mRNAEU429700.1 GI:167859365Influenza A virus (A / duck / Eastern China / 18 / 2005(H3N8)) segment 6 neuraminidase (NA) mRNA, complete cds1,460 bp linear mRNAEU429787.1 GI:167859539Influenza A virus (A / duck / Eastern China / 119 / 2005(H3N8)) segment 6 neuraminidase (NA) mRNA, complete cds1,460 bp linear mRNAEU429788.1 GI:167859541Influenza A virus (A / equine / Argentina / 1 / 96(H3N8)) hemagglutinin precursor (HA1) mRNA, partial cds1,061 bp linear mRNAAF197246.1 GI:6651512Influenza A virus (A / equine / Argentina / 2 / 94(H3N8)) hemagglutinin precursor (HA1) mRNA, partial cds1,061 bp linear mRNAAF197245.1 GI:6651510Influenza A virus (A / equine / Argentina / 1 / 95(H3N8)) hemagglutinin precursor (HA1) mRNA, partial cds1,061 bp linear mRNAAF197244.1 GI:6651508Influenza A virus HA partial gene for haemagglutinin, genomic RNA, strain A / equine / Berlin / 3 / 89(H3N8)1,026 bp linear mRNAAJ223194.1 GI:2780201Influenza A virus HA partial gene for haemagglutinin, genomic RNA, strain A / equine / Berlin / 4 / 89(H3N8)1,006 bp linear mRNAAJ223195.1 GI:2780203Influenza A virus (A / equine / Florida / 1 / 94(H3N8)) hemagglutinin precursor (HA1) mRNA, partial cds1,061 bp linear mRNAAF197242.1 GI:6651504Influenza A virus (A / equine / Grobois / 1 / 98(H3N8)) nonstructural protein NS1 mRNA, complete cds695 bp linear mRNAAY328471.1 GI:32966577Influenza A virus (A / equi 2 / Gotland / 01(H3N8)) hemagglutinin HA1 subunit mRNA, partial cds473 bp linear mRNAAY919314.1 GI:60250543Influenza A virus (A / eq / Kentucky / 81(H3N8)) hemagglutinin mRNA, complete cds1,763 bp linear mRNAU58195.1 GI:1377873Influenza A virus (A / equine / Kentucky / 9 / 95(H3N8)) hemagglutinin precursor (HA1) mRNA, partial cds1,061 bp linear mRNAAF197247.1 GI:6651514Influenza A virus (A / equine / Kentucky / 1 / 96(H3N8)) hemagglutinin precursor (HA1) mRNA, partial cds1,061 bp linear mRNAAF197248.1 GI:6651516Influenza A virus (A / equine / Kentucky / 1 / 97(H3N8)) hemagglutinin precursor (HA1) mRNA, partial cds1,061 bp linear mRNAAF197249.1 GI:6651518Influenza A virus (A / equine / Kentucky / 1 / 98(H3N8)) hemagglutinin precursor (HA1) mRNA, partial cds1,061 bp linear mRNAAF197241.1 GI:6651502Influenza A virus (A / equine / Santiago / 85(H3N8)) nucleoprotein mRNA, complete cds1,497 bp linear mRNAAY383753.1 GI:37223511Influenza A virus (A / equine / Santiago / 85(H3N8)) hemagglutinin mRNA, complete cds1,698 bp linear mRNAAY383755.1 GI:37223515Influenza A virus (A / equine / Santiago / 85(H3N8)) neuraminidase mRNA, complete cds1,413 bp linear mRNAAY383754.1 GI:37223513Influenza A virus (A / equine / Saskatoon / 1 / 90(H3N8)) hemagglutinin precursor (HA1) mRNA, partial cds1,061 bp linear mRNAAF197243.1 GI:6651506Influenza A virus (A / mallard / Alberta / l14 / 97 (H3N8)) nonfunctional matrix protein mRNA, partial sequence1,010 bp linear mRNAAY664432.1 GI:51011836Influenza A virus (A / mallard / Alberta / 167 / 98 (H3N8)) nonfunctional matrix protein mRNA, partial sequence961 bp linear mRNAAY664489.1 GI:51011893Influenza A virus (A / pintail / Alberta / 37 / 99(H3N8)) nonfunctional matrix protein mRNA, partial sequence970 bp linear mRNAAY664445.1 GI:51011849Influenza A virus (A / sanderling / Delaware / 65 / 99 (H3N8)) nonfunctional matrix protein mRNA, partial sequence922 bp linear mRNAAY664455.1 GI:51011859 Table 10. Other Influenza A Antigens (H4N ∗< -H13N ∗< ) SEQ ID NO Strain / Protein GenBank Access No. H4N ∗< 1215A / chicken / Singapore / 1992(H4N1) M2 proteinEU014144.11216A / mallard / Alberta / 47 / 98(H4N1) nonfunctional matrix proteinA Y664488.11217A / duck / Hong Kong / 412 / 1978(H4N2) polymerase (PB1)U48279.11218A / mallard / Alberta / 300 / 77 (H4N3) nonfunctional matrix proteinAY664480.11219A / Duck / Czechoslovakia / 56(H4N6) segment 4 hemagglutininAF290436.11220A / duck / Eastern China / 376 / 2004(H4N6) segment 6neuraminidase (NA)EU429792.11221A / duck / Eastern China / 01 / 2007(H4N6) segment 6 neuraminidase (NA)EU429790.11222A / duck / Eastern China / 216 / 2007(H4N6) segment 6 neuraminidase (NA)EU429789.11223A / duck / Eastern China / 166 / 2004(H4N6) segment 6 neuraminidase (NA)EU429746.11224A / duck / Eastern China / 02 / 2003(H4N6) segment 6 neuraminidase (NA)EU429713.11225A / duck / Eastern China / 160 / 2002(H4N6) segment 6 neuraminidase (NA)EU429706.11226A / mallard / Alberta / 111 / 99(H4N6) nonfunctional matrix proteinA Y664482.11227A / mallard / Alberta / 213 / 99 (H4N6) nonfunctional matrix proteinAY664460.11228A / mallard / Alberta / 30 / 98 (H4N6) nonfunctional matrix proteinAY664484.11229A / blue-winged teal / Alberta / 96 / 76 (H4N8) nonfunctional matrix proteinA Y664420.1 H5N ∗< 1230A / chicken / Florida / 25717 / 1993(H5N2) hemagglutininU05332.11231A / chicken / Hidalgo / 26654-1368 / 1994(H5N2) hemagglutinin (HA)U37172.11232A / chicken / Jalisco / 14585-660 / 1994(H5N2) hemagglutinin (HA)U37181.11233A / chicken / Mexico / 26654-1374 / 1994(H5N2) hemagglutinin (HA)U37173.11234A / chicken / Mexico / 31381-3 / 1994(H5N2) hemagglutinin (HA)U37176.11235A / chicken / Mexico / 31381-6 / 1994(H5N2) hemagglutinin (HA)U37175.11236A / chicken / Mexico / 31381-4 / 1994(H5N2) hemagglutinin (HA)U37174.11237A / chicken / Mexico / 31381-5 / 1994(H5N2) hemagglutinin (HA)U37169.11238A / chicken / Mexico / 31381-8 / 1994(H5N2) hemagglutinin (HA)U37170.11239A / Chicken / Mexico / 31381-Avilab / 94(H5N2)hemagglutinin (HA)L46585.11240A / chicken / Mexico / 31382-1 / 1994(H5N2)hemagglutinin (HA)U37168.11241A / chicken / Mexico / 31381-2 / 1994(H5N2) hemagglutinin (HA)U37167.11242A / chicken / Mexico / 31381-1 / 1994(H5N2) hemagglutinin (HA)U37166.11243A / chicken / Mexico / 31381-7 / 1994(H5N2) hemagglutinin (HA)U37165.11244A / chicken / Pennsylvania / 13609 / 1993(H5N2) hemagglutininU05331.11245A / chicken / Pennsylvania / 1 / 1983(H5N2) hemagglutinin esterase precursorM18001.11246A / chicken / Pennsylvania / 1370 / 1983(H5N2) hemagglutinin esterase precursorM10243.11247A / Chicken / Puebla / 8623-607 / 94(H5N2) hemagglutinin (HA)L46586.11248A / chicken / Puebla / 14586-654 / 1994(H5N2) hemagglutinin (HA)U37180.11249A / chicken / Puebla / 14585-622 / 1994(H5N2) hemagglutinin (HA)U37179.11250A / chicken / Puebla / 8623-607 / 1994(H5N2)hemagglutinin (HA)U37178.11251A / chicken / Puebla / 8624-604 / 1994(H5N2) hemagglutinin (HA)U37177.11252A / Chicken / Queretaro / 14588-19 / 95(H5N2) hemagglutinin (HA)L46587.11253A / chicken / Queretaro / 7653-20 / 95(H5N2) hemagglutinin (HA)U79448.11254A / chicken / Queretaro / 26654-1373 / 1994(H5N2) hemagglutinin (HA)U37171.11255A / chicken / Queretaro / 14588-19 / 1994(H5N2)hemagglutinin (HA)U37182.11256A / chicken / Singapore / 98(H5N2) matrix protein 2 (M2)EF682127.11257A / chicken / Taiwan / 1209 / 03(H5N2) hemagglutinin protein (HA)AY573917.11258A / chicken / Taiwan / 1209 / 03(H5N2) neuraminidaseAY573918.11259A / duck / Eastern China / 64 / 2004(H5N2) segment 6 neuraminidase (NA)EU429791.11260A / duck / Eastern China / 264 / 2002(H5N2) segment 6 neuraminidase (NA)EU429744.11261A / duck / Eastern China / 01 / 2001(H5N2) segment 6 neuraminidase (NA)EU429728.11262A / duck / Eastern China / 06 / 2000(H5N2) segment 6 neuraminidase (NA)EU429722.11263A / duck / Hong Kong / 342 / 78(H5N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107452.11264A / duck / Hong Kong / 342 / 78(H5N2) hemagglutinin precursorU20475.11265A / duck / Michigan / 80(H5N2) hemagglutinin 1 chainU20474.11266A / duck / Michigan / 80(H5N2) hemagglutininU79449.11267A / duck / MN / 1564 / 81(H5N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107467.11268A / duck / Mongolia / 54 / 2001(H5N2) hemagglutinin (HA)AB241614.21269A / duck / Primorie / 2621 / 01(H5N2) hemagglutinin (HA)AJ621811.31270A / duck / Primorie / 2621 / 01(H5N2)nucleoprotein (NP )AJ621812.11271A / duck / Primorie / 2621 / 01(H5N2) nonstructural protein (NS)AJ621813.11272A / duck / Pennsylvania / 84(H5N2) hemagglutinin 1chainU20473.11273A / duck / Potsdam / 1402-6 / 86(H5N2) hemagglutinin H5AF082042.11274A / emu / Texas / 39442 / 93(H5N2) hemaglutininU28920.11275A / emu / Texas / 39442 / 93(H5N2) hemaglutininU28919.11276A / mallard / Alberta / 645 / 80(H5N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107471.11277A / mallard / AR / 1C / 2001(H5N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107463.11278A / mallard / NY / 189 / 82(H5N2) matrix protein 1 (M) and matrix protein 2 (M)DQ 107465.11279A / mallard / MN / 25 / 80(H5N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107473.11280A / mallard / MI / 18 / 80(H5N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107470.11281A / mallard / Ohio / 345 / 88(H5N2) hemagglutininU79450.11282A / parrot / CA / 6032 / 04(H5N2) polymerase basic protein 2 (PB2)DQ256390.11283A / parrot / CA / 6032 / 04(H5N2) polymerase basic protein 1 (PB1)DQ256389.11284A / parrot / CA / 6032 / 04(H5N2) matrix protein (M)DQ256384.21285A / parrot / CA / 6032 / 04(H5N2) hemagglutinin (HA)DQ256383.11286A / parrot / CA / 6032 / 04(H5N2) neuraminidase (NA)DQ256385.11287A / parrot / CA / 6032 / 04(H5N2) polymerase basic protein 2 (PB2)DQ256390.11288A / parrot / CA / 6032 / 04(H5N2) nucleoprotein (NP)DQ256386.11289A / parrot / CA / 6032 / 04(H5N2)) polymerase (PA)DQ256388.11290A / ruddy turnstone / Delaware / 244 / 91 (H5N2) nonfunctional matrix proteinAY664474.11291A / ruddy turnstone / Delaware / 244 / 91 (H5N2)U05330.11292A / turkey / Colorado / 72(H5N2) hemagglutinin 1 chain (HA)U20472.11293A / turkey / England / N28 / 73 (H5N2) hemagglutininA Y500365.11294A / turkey / TX / 14082 / 81(H5N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107464.11295A / turkey / MN / 1704 / 82(H5N2)) matrix protein 1 (M) and matrix protein 2 (M)DQ107472.11296A / turkey / Minnesota / 10734 / 95(H5N2)) hemagglutininU79455.11297A / turkey / Minnesota / 3689-1551 / 81(H5N2) hemagglutininU79454.11298A / chicken / Singapore / 1997(H5N3) M2 proteinEU014141.11299A / duck / Hokkaido / 299 / 04(H5N3) hemagglutinin (HA)AB241626.11300A / duck / Hokkaido / 193 / 04(H5N3) hemagglutinin (HA)AB241625.11301A / duck / Hokkaido / 101 / 04(H5N3) hemagglutinin (HA)AB241624.11302A / duck / Hokkaido / 447 / 00(H5N3) hemagglutinin (HA)AB241620.11303A / duck / Hokkaido / 69 / 00(H5N3) hemagglutinin (HA)AB241619.11304A / duck / Hong Kong / 205 / 77(H5N3) hemagglutinin H5AF082038.11305A / duck / Hong Kong / 698 / 79(H5N3) hemagglutinin H5AF082039.11306A / duck / Hong Kong / 308 / 78(H5N3) matrix protein 1 (M) and matrix protein 2 (M)DQ107457.11307A / duck / Hong Kong / 825 / 80(H5N3) matrix protein 1 (M) and matrix protein 2 (M)DQ107455.11308A / duck / Hong Kong / 820 / 80(H5N3) matrix protein 1 (M) and matrix protein 2 (M)DQ107453.11309A / duck / Hong Kong / 205 / 77(H5N3) matrix protein 1 (M) and matrix protein 2 (M)DQ107456.11310A / Duck / Ho Chi Minh / 014 / 78(H5N3) segment 4 hemagglutininAF290443.11311A / duck / Jiangxi / 6151 / 2003(H5N3) matrix protein 1 (M) and matrix protein 2 (M)DQ107451.11312A / duck / Malaysia / F119-3 / 97(H5N3) hemagglutininAF303057.11313A / duck / Miyagi / 54 / 76(H5N3)hemagglutinin (HA)AB241615.11314A / duck / Mongolia / 596 / 01(H5N3) hemagglutinin HA)AB241622.11315A / duck / Mongolia / 500 / 01(H5N3)hemagglutinin (HA)AB241621.11316A / duck / Primorie / 2633 / 01(H5N3) matrix protein (M1)AJ621810.11317A / duck / Primorie / 2633 / 01(H5N3)nucleoprotein (NP)AJ621808.11318A / duck / Primorie / 2633 / 01(H5N3)hemagglutinin (HA )AJ621807.11319A / duck / Primorie / 2633 / 01(H5N3)nucleoprotein (NP)AJ621809.11320A / goose / Hong Kong / 23 / 78(H5N3) matrix protein 1 (M) and matrix protein 2 (M)DQ107454.11321A / mallard / Wisconsin / 169 / 75(H5N3) hemagglutininU79452.11322A / swan / Hokkaido / 51 / 96(H5N3)hemagglutinin (HA)AB241617.11323A / swan / Hokkaido / 4 / 96(H5N3) hemagglutinin (HA)AB241616.11324A / turkey / CA / 6878 / 79(H5N3) matrix protein 1 (M) and matrix protein 2 (M)DQ107469.11325A / tern / South Africa / 61(H5N3) hemagglutinin precursor (HA)U20460.11326A / gull / Delaware / 5 / 2000(H5N4) matrix protein 1 (M) and matrix protein 2 (M)DQ107459.11327A / gull / Delaware / 4 / 2000(H5N4) matrix protein 1 (M) and matrix protein 2 (M)DQ107458.11328A / shorebird / Delaware / 109 / 2000(H5N4) matrix protein 1 (M)DQ107460.11329A / shorebird / Delaware / 243 / 2000(H5N4) matrix protein 1 (M) and matrix protein 2 (M)DQ107462.11330A / shorebird / Delaware / 230 / 2000(H5N4) matrix protein 1 (M) and matrix protein 2 (M)DQ107461.11331A / mallard / Wisconsin / 34 / 75(H5N6) hemagglutininU79451.11332A / duck / Potsdam / 2216-4 / 1984(H5N6) hemagglutinin H5AF082041.11333A / shorebird / Delaware / 207 / 98 (H5N8) nonfunctional matrix proteinA Y664456.11334A / shorebird / Delaware / 27 / 98 (H5N8) nonfunctional matrix proteinA Y664453.11335A / herring gull / Delaware / 281 / 98 (H5N8) nonfunctional matrix proteinA Y664452.11336A / mallard / Ohio / 556 / 1987(H5N9) hemagglutinin (HA)U67783.21337A / turkey / Wisconsin / 68(H5N9) hemagglutininU79456.1 H6N ∗< 1338A / blue-winged teal / Alberta / 685 / 82(H6N1) matrix protein 1 (M) and matrix protein 2 (M)DQ107448.11339A / chicken / Taiwan / 7-5 / 99(H6N1) nucleocapsid protein (NP)AF261750.11340A / chicken / Taiwan / 7-5 / 99(H6N1) matrix proteinAF262213.11341A / chicken / Taiwan / 7-5 / 99(H6N1) nonstructural proteinAF262212.11342A / chicken / Taiwan / 7-5 / 99(H6N1) polymerase (PA)AF262211.11343A / chicken / Taiwan / 7-5 / 99(H6N1) polymerase subunit PB1AF262210.11344A / chicken / Taiwan / 7-5 / 99(H6N1) nucleocapsid protein (NP)AF261750.11345A / chicken / Taiwan / ns2 / 99(H6N1) segment 4 hemagglutinin (HA1)AF310985.11346A / chicken / Taiwan / na3 / 98(H6N1) segment 4 hemagglutinin (HA1)AF310984.11347A / chicken / Taiwan / 7-5 / 99(H6N1) segment 4 hemagglutinin (HA1)AF310983.11348A / duck / Hong Kong / D73 / 76(H6N1) matrix protein 1 (M) and matrix protein 2 (M)DQ107432.11349A / duck / Taiwan / 9 / 23-3 / 2000(H6N1) matrix protein 1 (M) and matrix protein 2 (M)DQ107407.11350A / pheasant / Hong Kong / FY479 / 2000(H6N1) matrix protein 1 (M) and matrix protein 2 (M)DQ107409.11351A / pheasant / Hong Kong / SSP44 / 2002(H6N1) matrix protein 1 (M) and matrix protein 2 (M)DQ107412.11352A / quail / Hong Kong / YU421 / 2002(H6N1) matrix protein 1 (M) and matrix protein 2 (M)DQ107414.11353A / avian / NY / 17150-7 / 2000(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107423.11354A / chicken / CA / 285 / 2003(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107429.11355A / chicken / CA / 375TR / 2002(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107428.11356A / chicken / CA / 203 / 2003(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107426.11357A / chicken / NY / 101250-7 / 2001(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107419.11358A / chicken / CA / 625 / 2002(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107418.11359A / Chicken / California / 0139 / 2001(H6N2)nucleoprotein (NP)AF474070.11360A / Chicken / California / 650 / 2000(H6N2) nucleoprotein (NP)AF474069.11361A / Chicken / California / 9420 / 2001(H6N2) neuraminidase N2 (N2)AF474048.11362A / Chicken / California / 9174 / 2001(H6N2) neuraminidase N2 (N2)AF474047.11363A / Chicken / California / 8892 / 2001(H6N2)neuraminidase N2 (N2)AF474046.11364A / Chicken / California / 6643 / 2001(H6N2) neuraminidase N2 (N2)AF474045.11365A / Chicken / California / 1316 / 2001(H6N2)neuraminidase N2 (N2)AF474044.11366A / Chicken / California / 0139 / 2001(H6N2) neuraminidase N2 (N2)AF474043.11367A / Chicken / California / 1002 / 2000(H6N2) neuraminidase N2 (N2)AF474042.11368A / Chicken / California / 650 / 2000(H6N2) neuraminidase N2 (N2)AF474041.11369A / Chicken / California / 465 / 2000(H6N2) neuraminidase N2 (N2)AF474040.11370A / Chicken / California / 431 / 2000(H6N2) neuraminidase N2 (N2)AF474039.11371A / Chicken / California / 6643 / 2001(H6N2) hemagglutinin H6 (H6)AF474035.11372A / Chicken / California / 431 / 2000(H6N2) hemagglutinin H6 (H6)AF474029.11373A / Chicken / California / 9420 / 2001(H6N2) hemagglutinin H6 (H6)AF474038.11374A / Chicken / California / 9174 / 2001(H6N2) hemagglutinin H6 (H6)AF474037.11375A / Chicken / California / 8892 / 2001(H6N2) hemagglutinin H6 (H6)AF474036.11376A / Chicken / California / 1316 / 2001(H6N2) hemagglutinin H6 (H6)AF474034.11377A / Chicken / California / 0139 / 2001(H6N2) hemagglutinin H6 (H6)AF474033.11378A / Chicken / California / 1002 / 2000(H6N2) hemagglutinin H6 (H6)AF474032.11379A / Chicken / California / 650 / 2000(H6N2) hemagglutinin H6 (H6)AF474031.11380A / Chicken / California / 465 / 2000(H6N2) hemagglutinin H6 (H6)AF474030.11381A / cornish cross / CA / 139 / 2001(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107424.11382A / duck / Eastern China / 164 / 2002(H6N2) segment 6 neuraminidase (NA)EU429762.11383A / duck / Eastern China / 729 / 2003(H6N2) segment 6 neuraminidase (NA)EU429760.11384A / duck / Eastern China / 262 / 2002(H6N2) segment 6 neuraminidase (NA)EU429743.11385A / duck / Eastern China / 74 / 2006(H6N2) segment 6 neuraminidase (NA)EU429741.11386A / duck / Eastern China / 161 / 2002(H6N2) segment 6 neuraminidase (NA)EU429740.11387A / duck / Hong Kong / 960 / 80(H6N2)) matrix protein 1 (M) and matrix protein 2 (M)DQ107435.11388A / duck / Hong Kong / D134 / 77(H6N2)) matrix protein 1 (M) and matrix protein 2 (M)DQ107433.11389A / duck / CA / 10221 / 2002(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107421.11390A / duck / Shantou / 5540 / 2001(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107431.11391A / guinea fowl / Hong Kong / SSP99 / 2002(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107413.11392A / mallard / NY / 016 / 83(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107449.11393A / mallard / NY / 046 / 83(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107450.11394A / pintail / Alberta / 644 / 81(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107445.11395A / quail / Hong Kong / SF792 / 2000(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107410.11396A / ruddy turnstone / Delaware / 106 / 98 (H6N2) nonfunctional matrix proteinAY664439.11397A / Shorebird / Delaware / 127 / 97(H6N2) nonfunctional matrix proteinAY664467.11398A / shorebird / Delaware / 124 / 2001(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107417.11399A / shorebird / Delaware / 208 / 2001(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107427.11400A / turkey / CA / 527 / 2002(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107420.11401A / turkey / CA / 1623CT / 2002(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107425.11402A / turkey / MN / 836 / 80(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107440.11403A / turkey / MN / 735 / 79(H6N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107437.11404A / chicken / Hong Kong / 17 / 77(H6N4)) matrix protein 1 (M) and matrix protein 2 (M)DQ107436.11405A / chicken / Hong Kong / CSW106 / 2001(H6N4) matrix protein 1 (M) and matrix protein 2 (M)DQ107406.11406A / gull / Delaware / 18 / 2000(H6N4) matrix protein 1 (M) and matrix protein 2 (M)DQ107415.11407A / pheasant / Hong Kong / CSW2573 / 2001(H6N4) matrix protein 1 (M) and matrix protein 2 (M)DQ107411.11408A / quail / Hong Kong / CSW106 / 2001(H6N4) matrix protein 1 (M) and matrix protein 2 (M)DQ107430.11409A / Shorebird / Delaware / 194 / 98(H6N4) nonfunctional matrix proteinA Y664424.11410A / shorebird / Delaware / 259 / 2000(H6N4) matrix protein 1 (M) and matrix protein 2 (M)DQ107416.11411A / shearwater / Australia / 1 / 1972(H6N5) segment 6 neuraminidase (NA)EU429794.11412A / shearwater / Australia / 1 / 1972(H6N5) polymerase A (PA)L25832.11413A / pintail / Alberta / 1040 / 79(H6N5) matrix protein 1 (M) and matrix protein 2 (M)DQ107439.11414A / blue-winged teal / MN / 993 / 80(H6N6)) matrix protein 1 (M) and matrix protein 2 (M)DQ107441.11415A / duck / NY / 83779 / 2002(H6N6) matrix protein 1 (M) and matrix protein 2 (M)DQ107422.11416A / duck / MN / 1414 / 81(H6N6) matrix protein 1 (M) and matrix protein 2 (M)DQ107444.11417A / mallard / Alberta / 289 / 82(H6N6) matrix protein 1 (M) and matrix protein 2 (M)DQ107447.11418A / mallard duck / MN / 1041 / 80(H6N6) matrix protein 1 (M) and matrix protein 2 (M)DQ107442.11419A / pintail / Alberta / 189 / 82(H6N6) matrix protein 1 (M) and matrix protein 2 (M)DQ107446.11420A / sanderling / Delaware / 1258 / 86(H6N6) nonfunctional matrix proteinAY664436.11421A / blue-winged teal / Alberta / 368 / 78(H6N8)) matrix protein 1 (M) and matrix protein 2 (M)DQ107438.11422A / ruddy turnstone / Delaware / 105 / 98 (H6N8) nonfunctional matrix proteinAY664428.11423A / domestic duck / NY / 81(H6N8)) matrix protein (M)DQ107443.11424A / duck / Eastern China / 163 / 2002(H6N8) segment 6 neuraminidase (NA)EU429786.11425A / duck / Hong Kong / D182 / 77(H6N9) matrix protein 1 (M) and matrix protein 2 (M)DQ107434.11426A / chicken / Hong Kong / SF3 / 2001(H6) matrix protein 1 (M) and matrix protein 2 (M)DQ107408.1H7N ∗< 1427A / African starling / England / 983 / 79(H7N1) neuraminidase (N1)AJ416629.11428A / Afri.Star. / Eng-Q / 938 / 79(H7N1) hemagglutinin precurosrAF149295.11429A / chicken / Italy / 1067 / 99(H7N1) matrix protein 1 (M1)AJ416630.11430A / chicken / Italy / 1067 / 99(H7N1) neuraminidase (N1)AJ416627.11431A / chicken / Italy / 4575 / 99(H7N1) hemagglutinin (HA)AJ493469.11432A / chicken / Italy / 13474 / 99(H7N1) haemagglutinin (HA)AJ491720.11433A / chicken / Italy / 445 / 1999(H7N1)AX537385.11434A / Chicken / Italy / 267 / 00(H7N1) hemagglutinin (HA)AJ493215.11435A / Chicken / Italy / 13489 / 99(H7N1) hemagglutinin (HA)AJ493214.11436A / Chicken / Italy / 13307 / 99(H7N1) hemagglutinin (HA)AJ493212.11437A / chicken / Singapore / 1994(H7N1) M2 proteinEU014140.11438A / duck / Hong Kong / 301 / 78(H7N1) matrix protein 1 (M) and matrix protein 2 (M)DQ107475.11439A / Hong Kong / 301 / 78(H7N1) hemagglutinin (HA)A Y672090.11440A / fowl plaguq virus / Rostock / 34 (H7N1) NP proteinAJ243993.11441A / fowl plaguq virus / Rostock / 34 (H7N1) PA proteinAJ243992.11442A / fowl plaguq virus / Rostock / 34 (H7N1) PB2 proteinAJ243991.11443A / fowl plaguq virus / Rostock / 34 (H7N1) PB1 proteinAJ243990.11444A / ostrich / South Africa / 5352 / 92(H7N1) hemagglutinin precursor (HA)U20458.11445A / rhea / North Carolina / 39482 / 93(H7N1) hemagglutinin precursor (HA)U20468.11446A / turkey / Italy / 3775 / 99 (H7N1) hemagglutinin (HA)AJ493472.11447A / turkey / Italy / 4603 / 99 (H7N1) hemagglutinin (HA)AJ493471.11448A / turkey / Italy / 4602 / 99 (H7N1) hemagglutinin (HA)AJ493470.11449A / turkey / Italy / 4169 / 99 (H7N1) hemagglutinin (HA)AJ493468.11450A / turkey / Italy / 4073 / 99 (H7N1) hemagglutinin (HA)AJ493467.11451A / turkey / Italy / 3889 / 99 (H7N1) hemagglutinin (HA)AJ493466.11452A / turkey / Italy / 12598 / 99(H7N1) haemagglutinin (HA)AJ489520.11453A / turkey / Italy / 4580 / 99(H7N1) haemagglutinin (HA)AJ416628.11454A / Turkey / Italy / 335 / 00(H7N1) haemagglutinin (HA)AJ493217.11455A / Turkey / Italy / 13468 / 99(H7N1) haemagglutinin (HA)AJ493216.11456A / Turkey / Italy / 13467 / 99(H7N1) haemagglutinin (HA)AJ493213.11457A / chicken / CT / 9407 / 2003(H7N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107478.11458A / chicken / NY / 116124 / 2003(H7N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107479.11459A / chicken / PA / 143586 / 2002(H7N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107477.11460A / duck / Hong Kong / 293 / 78(H7N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107474.11461A / duck / Hong Kong / 293 / 78(H7N2) hemagglutinin precursor (HA)U20461.11462A / laughing gull / Delaware / 2838 / 87 (H7N2) nonfunctional matrix proteinAY664427.11463A / pheasant / NJ / 30739-9 / 2000(H7N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107481.11464A / ruddy turnstone / Delaware / 130 / 99 (H7N2) onfunctional matrix proteinAY664451.11465A / unknown / 149717-12 / 2002(H7N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107480.11466A / unknown / NY / 74211-5 / 2001(H7N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107476.11467A / unknown / 149717-12 / 2002(H7N2) matrix protein 1 (M) and matrix protein 2(M)DQ107480.11468A / unknown / NY / 74211-5 / 2001(H7N2) matrix protein 1(M) and matrix protein 2 (M)DQ107476.11469A / chicken / British Columbia / CN7-3 / 04 (H7N3) hemagglutinin (HA)AY644402.11470A / chicken / British Columbia / CN7-3 / 04 (H7N3) matrix protein (M1)A Y677732.11471A / chicken / Italy / 270638 / 02(H7N3) hemagglutinin (HA)EU158111.11472A / gadwall / MD / 3495 / 83(H7N3) matrix protein 1 (M) and matrix protein 2 (M)DQ107488.11473A / mallard / Alberta / 22 / 2001(H7N3) matrix protein 1 (M) and matrix protein 2 (M)DQ107482.11474A / mallard / Alberta / 699 / 81(H7N3) matrix protein 1 (M) and matrix protein 2 (M)DQ107487.11475A / pintail / Alberta / 25 / 2001(H7N3) matrix protein 1 (M) and matrix protein 2 (M)DQ107483.11476A / Quail / Arkansas / 16309-7 / 94 (H7N3) hemagglutinin protein subunit 1 precursor (HA1)AF072401.11477A / ruddy turnstone / New Jersey / 65 / 85(H7N3) nonfunctional matrix proteinA Y664433.11478A / turkey / England / 63(H7N3) hemagglutinin precursor (HA)U20462.11479A / Turkey / Colorado / 13356 / 91 (H7N3) hemagglutinin protein subunit 1 precursor (HA1)AF072400.11480A / turkey / MN / 1200 / 80(H7N3)) matrix protein 1 (M) and matrix protein 2 (M)DQ107486.11481A / turkey / MN / 1818 / 82(H7N3) matrix protein 1 (M) and matrix protein 2 (M)DQ107489.11482A / turkey / Minnesota / 1237 / 80(H7N3) hemagglutinin precursor (HA)U20466.11483A / turkey / TX / 1 / 79(H7N3) matrix protein 1 (M) and matrix protein 2 (M)DQ107484.11484A / Turkey / Oregon / 71(H7N3) hemagglutininAF497557.11485A / Turkey / Utah / 24721-10 / 95 (H7N3) hemagglutinin protein subunit 1 precursor (HA1)AF072402.11486A / softbill / South Africa / 142 / 92(H7N4) hemagglutinin precursor (HA)U20464.11487A / ruddy turnstone / Delaware / 2770 / 87 (H7N5) nonfunctional matrix proteinAY664476.11488A / chicken / Brescia / 1902(H7N7) hemagglutinin 1 chain (HA)U20471.11489A / chicken / Jena / 1816 / 87(H7N7) hemagglutinin precursor (HA)U20469.11490A / chicken / Leipzig / 79(H7N7) hemagglutinin precursor (HA)U20459.11491A / duck / Heinersdorf / S495 / 6 / 86(H7N7) hemagglutinin precursor (HA)U20465.11492A / equine / Prague / 1 / 56 (H7N7) neuraminidaseU85989.11493A / equine / Santiago / 77(H7N7) nucleoproteinA Y383752.11494A / equine / Santiago / 77(H7N7) neuraminidaseAY383757.11495A / equine / Santiago / 77(H7N7) hemagglutininA Y383756.11496A / FPV / Weybridge(H7N7) matrix proteinM38299.11497A / goose / Leipzig / 187 / 7 / 1979(H7N7) hemagglutininL43914.11498A / goose / Leipzig / 192 / 7 / 1979(H7N7) hemagglutininL43915.11499A / goose / Leipzig / 137 / 8 / 1979(H7N7) hemagglutininL43913.11500A / ruddy turnstone / Delaware / 134 / 99 (H7N7) nonfunctional matrix proteinA Y664468.11501A / seal / Mass / 1 / 80 H7N7 recombinantS73497.11502A / swan / Potsdam / 63 / 6 / 81(H7N7) hemagglutinin precursor (HA)U20467.11503A / tern / Potsdam / 342 / 6 / 79(H7N7) hemagglutinin precursor (HA)U20470.11504A / pintail / Alberta / 121 / 79(H7N8) matrix protein 1 (M) and matrix protein 2 (M)DQ107485.11505A / Turkey / Minnesota / 38429 / 88(H7N9) hemagglutininAF497551.1 H8N ∗< 1506A / turkey / Ontario / 6118 / 1968(H8N4) segment 6 neuraminidase (NA)EU429793.11507A / Mallard Duck / Alberta / 357 / 84(H8N4) segment 4 hemagglutinin (HA1)AF310988.11508A / Pintail Duck / Alberta / 114 / 79(H8N4) segment 4 hemagglutinin (HA1)AF310987.11509A / duck / Eastern China / 01 / 2005(H8N4) segment 6 neuraminidase (NA)EU429780.11510A / Red Kont / Delaware / 254 / 94(H8N4) segment 4 hemagglutinin (HA1)AF310989.1H9N ∗< 1511A / chicken / Amioz / 1527 / 03(H9N2) nucleoproteinDQ116511.11512A / chicken / Amioz / 1527 / 03(H9N2) neuraminidaseDQ116081.11513A / chicken / Amioz / 1527 / 03(H9N2) hemagglutininDQ108911.11514A / chicken / Alonim / 1953 / 104(H9N2) hemagglutininDQ108928.11515A / chicken / Alonim / 1552 / 03(H9N2) hemagglutininDQ108914.11516A / chicken / Alonim / 1552 / 03(H9N2) nucleoproteinDQ116514.11517A / chicken / Alonim / 1965 / 04(H9N2) hemagglutininDQ108929.11518A / Chicken / Anhui / 1 / 98(H9N2) hemagglutinin (HA)AF461511.11519A / Chicken / Beijing / 1 / 95(H9N2) nonfunctional matrix proteinAF536719.11520A / Chicken / Beijing / 1 / 95(H9N2) nucleoprotein (NP)AF536699.11521A / Chicken / Beijing / 1 / 95(H9N2) nonfunctional nonstructural proteinAF536729.11522A / Chicken / Beijing / 1 / 95(H9N2) segment 6 neuraminidase (NA)AF536709.11523A / Chicken / Beijing / 2 / 97(H9N2) nucleoprotein (NP)AF536700.11524A / Chicken / Beijing / 2 / 97(H9N2) nonfunctional matrix proteinAF536720.11525A / Chicken / Beijing / 2 / 97(H9N2) nonfunctional nonstructural proteinAF536730.11526A / Chicken / Beijing / 2 / 97(H9N2) segment 6 neuraminidase (NA)AF536710.11527A / Chicken / Beijing / 1 / 97(H9N2) hemagglutinin (HA)AF461530.11528A / Chicken / Beijing / 3 / 99(H9N2) nonfunctional matrix proteinAF536721.11529A / Chicken / Beijing / 3 / 99(H9N2) nucleoprotein (NP)AF536701.11530A / Chicken / Beijing / 3 / 99(H9N2) nonfunctional nonstructural proteinAF536731.11531A / Chicken / Beijing / 3 / 99(H9N2) segment 6 neuraminidase (NA)AF536711.11532A / chicken / Beit Alfa / 1282 / 03(H9N2)hemagglutininDQ104476.11533A / chicken / Beit-Aran / 29 / 05(H9N2) hemagglutininDQ108931.11534A / chicken / Bnei Darom / 1557 / 03(H9N2) hemagglutininDQ108915.11535A / chicken / Ein Habsor / 1808 / 04(H9N2) hemagglutininDQ108925.11536A / Chicken / Gangxi / 2 / 00(H9N2) hemagglutinin (HA)AF461514.11537A / Chicken / Gangxi / 1 / 00(H9N2) hemagglutinin (HA)AF461513.11538A / chicken / Gan Shomron / 1465 / 03(H9N2) hemagglutininDQ104480.11539A / chicken / Gan Shomron / 1292 / 03(H9N2) hemagglutininDQ104478.11540A / chicken / Gan_Shomron / 1465 / 03(H9N2) nucleoproteinDQ116506.11541A / chicken / Gan_Shomron / 1465 / 03(H9N2) neuraminidaseDQ116077.11542A / chicken / Gan Shomron / 1543 / 04(H9N2) nucleoproteinDQ116512.11543A / chicken / Gan Shomron / 1543 / 04(H9N2) hemagglutininDQ108912.11544A / Chicken / Guangdong / 97(H9N2) nonfunctional matrix proteinAF536722.11545A / Chicken / Guangdong / 97(H9N2) nucleoprotein (NP)AF536702.11546A / Chicken / Guangdong / 97(H9N2) nonfunctional nonstructural proteinAF536732.11547A / Chicken / Guangdong / 97(H9N2) segment 6 neuraminidase (NA)AF536712.11548A / Chicken / Gansu / 1 / 99(H9N2) hemagglutinin (HA)AF461512.11549A / chicken / Gujrat / India / 3697 / 2004(H9N2) polymerase basic 2 (PB2)DQ979865.11550A / chicken / Haryana / India / 2424 / 2004(H9N2) polymerase basic 2 (PB2)DQ979862.11551A / Chicken / Henan / 98(H9N2) nonfunctional matrix proteinAF536726.11552A / Chicken / Henan / 98(H9N2) nucleoprotein (NP)AF536706.11553A / Chicken / Henan / 98(H9N2) nonfunctional nonstructural proteinAF536736.11554A / Chicken / Henan / 2 / 98(H9N2) hemagglutinin (HA)AF461517.11555A / Chicken / Henan / 1 / 99(H9N2) hemagglutinin (HA)AF461516.11556A / Chicken / Henan / 98(H9N2) segment 6 neuraminidase (NA)AF536716.11557A / Chicken / Hebei / 1 / 96(H9N2) nonfunctional matrix proteinAF536723.11558A / Chicken / Hebei / 1 / 96(H9N2) segment 6 nonfunctional neuraminidase proteinAF536713.11559A / Chicken / Hebei / 1 / 96(H9N2) nucleoprotein (NP)AF536703.11560A / Chicken / Hebei / 1 / 96(H9N2) nonfunctional nonstructural proteinAF536733.11561A / Chicken / Hebei / 1 / 96(H9N2) segment 6 nonfunctional neuraminidase proteinAF536713.11562A / Chicken / Hebei / 2 / 00(H9N2) hemagglutinin (HA)AF461531.11563A / Chicken / Hebei / 2 / 98(H9N2) nonfunctional matrix proteinAF536724.11564A / Chicken / Hebei / 2 / 98(H9N2) nucleoprotein (NP)AF536704.11565A / Chicken / Hebei / 2 / 98(H9N2) nonfunctional nonstructural proteinAF536734.11566A / Chicken / Hebei / 2 / 98(H9N2) segment 6 neuraminidase (NA)AF536714.11567A / Chicken / Hebei / 1 / 00(H9N2) hemagglutinin (HA)AF461515.11568A / Chicken / Hebei / 3 / 98(H9N2) nucleoprotein (NP)AF536705.11569A / Chicken / Hebei / 3 / 98(H9N2) nonfunctional matrix proteinAF536725.11570A / Chicken / Hebei / 3 / 98(H9N2) nonfunctional onstructural proteinAF536735.11571A / Chicken / Hebei / 3 / 98(H9N)) segment 6 neuraminidase (NA)AF536715.11572A / chicken / Hong Kong / FY313 / 2000(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107508.11573A / chicken / Hong Kong / WF208 / 2001(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107513.11574A / chicken / Hong Kong / NT471 / 2002(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107514.11575A / chicken / Hong Kong / WF2 / 99(H9N2) hemagglutininAY206677.11576A / chicken / Iarah / 1376 / 03(H9N2) nucleoproteinDQ116504.11577A / chicken / Iarah / 1376 / 03(H9N2) neuraminidaseDQ116075.11578A / chicken / Iarah / 1376 / 03(H9N2) hemagglutininDQ108910.11579A / chicken / India / 2793 / 2003(H9N2) hemagglutinin (HA)AY336597.11580A / chicken / Iran / 101 / 1998(H9N2) matrix protein 2 (M2)EU477375.11581A / Chicken / Jiangsu / 1 / 99(H9N)) hemagglutinin (HA)AF461509.11582A / Chicken / Jiangsu / 2 / 98(H9N2) hemagglutinin (HA)AF461510.11583A / chicken / Kfar Monash / 636 / 02(H9N2) hemagglutininDQ104464.11584A / chicken / Kalanit / 1966 / 06.12.04(H9N2) hemagglutininDQ108930.11585A / chicken / Kalanit / 1946 / 04(H9N2) hemagglutininDQ108927.11586A / chicken / Korea / S4 / 2003(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107517.11587A / Chicken / Korea / MS96 / 96(H9N2) matrix protein 1 and 2 (M)AF203788.11588A / Chicken / Korea / MS96 / 96(H9N2) neuraminidase subtype 2AF203786.11589A / Chicken / Korea / MS96 / 96(H9N2) nucleoproteinAF203787.11590A / Chicken / Liaoning / 99(H9N2) nonfunctional matrix proteinAF536727.11591A / Chicken / Liaoning / 1 / 00(H9N2) hemagglutinin (HA)AF461518.11592A / Chicken / Liaoning / 99(H9N2) nucleoprotein (NP)AF536707.11593A / Chicken / Liaoning / 99(H9N2) nonfunctional matrix proteinAF536727.11594A / Chicken / Liaoning / 99(H9N2) nonfunctional onstructural proteinAF536737.11595A / Chicken / Liaoning / 2 / 00(H9N2) hemagglutinin (HA)AF461519.11596A / chicken / Liaoning / 99(H9N2) segment 6 neuraminidase (NA)AF536717.11597A / chicken / Mudanjiang / 0823 / 2000(H9N2) nucleoprotein (NP)AY496851.11598A / Chicken / Mudanjiang / 0823 / 2000 (H9N2) nonstructural proteinAY631868.11599A / Chicken / Mudanjiang / 0823 / 00 (H9N2) hemagglutinin (HA)AY513715.11600A / chicken / Mudanjiang / 0823 / 2000(H9N2) matrix protein (M1)AY496852.11601A / chicken / Mudanjiang / 0823 / 2000(H9N2) nucleoprotein (np)AY496851.11602A / chicken / Maale HaHamisha / 90658 / 00(H9N2) hemagglutininDQ104472.11603A / chicken / Maanit / 1477 / 03(H9N2) hemagglutininDQ104483.11604A / chicken / Maanit / 1291 / 03(H9N2) hemagglutininDQ104477.11605A / chicken / Maanit / 1275 / 03(H9N2) hemagglutininDQ104457.11606A / chicken / Maanit / 1477 / 03(H9N2) nucleoproteinDQ116508.11607A / chicken / Netohah / 1373 / 03 (H9N2) nucleoproteinDQ116503.11608A / chicken / Netohah / 1373 / 03 (H9N2) neuraminidaseDQ116074.11609A / chicken / Netohah / 1373 / 03 (H9N2) hemagglutininDQ108909.11610A / chicken / Neve Ilan / 1504 / 03(H9N2) hemagglutininDQ104484.11611A / chicken / Neve_Ilan / 1504 / 03(H9N2) nucleoproteinDQ116509.11612A / chicken / Neve_Ilan / 1504 / 03(H9N2) neuraminidaseDQ116079.11613A / chicken / Orissa / India / 2317 / 2004(H9N2) polymerase basic 2 (PB2)DQ979861.11614A / chicken / Pardes-Hana-Carcur / 1475 / 03(H9N2) hemagglutininDQ104482.11615A / chicken / Pardes-Hana-Carcur / 1475 / 03(H9N2) neuraminidaseDQ116078.11616A / chicken / Saar / 1456 / 03(H9N2) hemagglutininDQ104479.11617A / chicken / Sde_Uziahu / 1747 / 04(H9N2) neuraminidaseDQ116068.11618A / chicken / Sede Uzziyyahu / 1651 / 04(H9N2) hemagglutininDQ108923.11619A / chicken / Sde Uziahu / 1747 / 04(H9N2)DQ108905.11620A / chicken / Singapore / 1998(H9N2) M2 proteinEU014142.11621A / chicken / Singapore / 1998(H9N2) M2 proteinEU014142.11622A / Chicken / Shandong / 98(H9N2) nonfunctional matrix proteinAF536728.11623A / Chicken / Shandong / 1 / 98(H9N2) hemagglutinin (HA)AF461520.11624A / Chicken / Shandong / 98(H9N2) nucleoprotein (NP)AF536708.11625A / Chicken / Shandong / 98(H9N2) nonfunctional nonstructural proteinAF536738.11626A / Chicken / Shandong / 98(H9N2) segment 6 neuraminidase (NA)AF536718.11627A / Chicken / Shandong / 2 / 99(H9N2) hemagglutinin (HA)AF461521.11628A / chicken / Shandong / 1 / 02(H9N2) neuraminidase (NA)A Y295761.11629A / Chicken / Shanghai / F / 98(H9N2) hemagglutininAF461532.11630A / Chicken / Shanghai / 1 / 02(H9N2) hemagglutininAY281745.11631A / Chicken / Shanghai / 2 / 99(H9N2)) hemagglutinin (HA)AF461522.11632A / Chicken / Shanghai / 3 / 00(H9N2)) hemagglutinin (HA)AF461523.11633A / Chicken / Shanghai / F / 98(H9N2) hemagglutinin (HA)AY743216.11634A / Chicken / Shanghai / 4-2 / 01(H9N2) hemagglutinin (HA)AF461525.11635A / Chicken / Shanghai / 4-1 / 01(H9N2) hemagglutinin (HA)AF461524.11636A / Chicken / Shanghai / 4 / 01(H9N2) hemagglutinin (HA)AY083841.11637A / Chicken / Shanghai / 3 / 01(H9N2) hemagglutinin HA)A Y083840.11638A / chicken / Talmei_Elazar / 1304 / 03(H9N2)nucleoproteinDQ116530.11639A / chicken / Talmei_Elazar / 1304 / 03(H9N2) neuraminidaseDQ116072.11640A / Chicken / Tianjing / 2 / 96(H9N2) hemagglutininAF461527.11641A / Chicken / Tianjing / 1 / 96(H9N2) hemagglutinin (HA)AF461526.11642A / chicken / Tel Adashim / 811 / 01 (H9N2) hemagglutininDQ104467.11643A / chicken / Tel Adashim / 811 / 01 (H9N2) nucleoproteinDQ116527.11644A / ck / Tel_Adashim / 811 / 01(H9N2) neuraminidaseDQ116064.11645A / chicken / Tel Adashim / 812 / 01 (H9N2) nucleoproteinDQ116528.11646A / chicken / Tel Adashim / 812 / 01 (H9N2) hemagglutininDQ104468.11647A / ck / Tel_Adashim / 812 / 01(H9N2) neuraminidaseDQ116065.11648A / chicken / Tel Adashim / 786 / 01 (H9N2) nucleoproteinDQ116524.11649A / chicken / Tel Adashim / 809 / 01 (H9N2) hemagglutininDQ104465.11650A / chicken / Tel Adashim / 809 / 01 (H9N2) nucleoproteinDQ116525.11651A / chicken / Tel Adashim / 1469 / 03 (H9N2) nucleoproteinDQ116507.11652A / chicken / Tel Adashim / 1469 / 303(H9N2) hemagglutininDQ104481.11653A / chicken / Tel Adashim / 1506 / 03 (H9N2) neuraminidaseDQ116080.11654A / chicken / Tel Adashim / 1506 / 03(H9N2) hemagglutininDQ104474.11655A / chicken / Tel Adashim / 1506 / 03 (H9N2) nucleoproteinDQ116510.11656A / chicken / Tel Adashim / 1332 / 03(H9N2) nucleoproteinDQ116501.11657A / chicken / Tel Adashim / 1321 / 03(H9N2) nucleoproteinDQ116500.11658A / chicken / Tel Adashim / 1332 / 03(H9N2) hemagglutininDQ108907.11659A / chicken / Tel Adashim / 1321 / 03(H9N2) hemagglutininDQ108906.11660A / chicken / Telmond / 1308 / 03(H9N2) nucleoproteinDQ116499.11661A / chicken / Telmond / 1308 / 03(H9N2) neuraminidaseDQ116073.11662A / chicken / Telmond / 1308 / 03(H9N2) hemagglutininDQ108921.11663A / chicken / Tzrofa / 1568 / 04(H9N2) nucleoproteinDQ116519.11664A / chicken / Tzrofa / 1568 / 04(H9N2) hemagglutininDQ108919.11665A / chicken / UP / India / 2544 / 2004(H9N2) polymerase basic 2 (PB2)DQ979864.11666A / chicken / UP / India / 2543 / 2004(H9N2) polymerase basic 2 (PB2)DQ979863.11667A / chicken / Wangcheng / 4 / 2001 (H9N2) nucleoproteinA Y268949.11668A / chicken / Ysodot / 1362 / 03(H9N2) nucleoproteinDQ116502.11669A / chicken / Ysodot / 1362 / 03(H9N2) hemagglutininDQ108908.11670A / Chicken / Yunnan / 2 / 00(H9N2) hemagglutinin (HA)AF461529.11671A / Chicken / Yunnan / 1 / 99(H9N2) hemagglutinin (HA)AF461528.11672A / duck / Eastern China / 01 / 2000(H9N2) segment 6 neuraminidase (NA)EU429725.11673A / duck / Eastern China / 48 / 2001(H9N2) segment 6 neuraminidase (NA)EU429707.11674A / duck / Eastern China / 66 / 2003(H9N2) segment 6 neuraminidase (NA)EU429699.11675A / duck / Eastern China / 80 / 2004(H9N2) segment 6 neuraminidase (NA)EU429726.11676A / duck / Hong Kong / 448 / 78(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107494.11677A / duck / Hong Kong / 448 / 78(H9N2) hemagglutinin precursorAY206673 .11678A / duck / Hong Kong / 366 / 78(H9N2) hemagglutinin precursorAY206674.11679A / duck / Hong Kong / 784 / 79(H9N2)) matrix protein 1(M) and matrix protein 2 (M)DQ107496.11680A / duck / Hong Kong / 702 / 79(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107495.11681 / duck / Hong Kong / 702 / 79(H9N2) hemagglutinin precursorA Y206672.11682A / duck / Hong Kong / 610 / 79(H9N2) hemagglutinin precursorA Y206680.11683A / duck / Hong Kong / 552 / 79(H9N2) hemagglutinin precursorA Y206679.11684A / duck / Hong Kong / 644 / 79(H9N2) hemagglutinin precursorAY206678.11685A / duck / Korea / S 13 / 2003 (H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107518.11686A / duck / Nanchang / 4-361 / 2001(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107511.11687A / duck / NY / 83793 / 2002(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107499.11688A / goose / MN / 5733-1243 / 80(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107492.11689A / geese / Tel Adashim / 829 / 01(H9N2) hemagglutininDQ104469.11690A / geese / Tel Adashim / 830 / 01(H9N2 hemagglutininDQ104470.11691A / ostrich / Eshkol / 1436 / 03(H9N2) neuraminidaseDQ116076.11692A / ostrich / Eshkol / 1436 / 03(H9N2) nucleoproteinDQ116505.11693A / pigeon / Hong Kong / WF286 / 2000(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107509.11694A / quail / Hong Kong / YU415 / 2002(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107516.11695A / quail / Hong Kong / SSP225 / 2001(H9) matrix protein 1 (M) and matrix protein 2 (M)DQ107512.11696A / quail / Hong Kong / YU1495 / 2000(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107510.11697A / quail / Hong Kong / A28945 / 88(H9N2) hemagglutinin precursorAY206675.11698A / shorebird / Delaware / 276 / 99 (H9N2) nonfunctional matrix proteinAY664464.11699A / shorebird / Delaware / 113 / 2001(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107505.11700A / silky chicken / Hong Kong / WF266 / 2002(H9N2) matrix protein 2 (M) and matrix protein 1 (M)DQ107515.11701A / shorebird / Delaware / 77 / 2001(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107497.11702A / guinea fowl / Hong Kong / WF10 / 99(H9N2) hemagglutinin precursorA Y206676.11703A / swine / Hangzhou / 1 / 2006(H9N2) nucleocapsid protein (NP)DQ907704.11704A / swine / Hangzhou / 1 / 2006(H9N2)) matrix protein 1 (M1)EF055887.11705A / swine / Hangzhou / 1 / 2006(H9N2)) nonstructural protein 1 (NS1)DQ823385.11706A / Sw / ShanDong / 1 / 2003(H9N2) hemagglutinin (HA)A Y294658.11707A / turkey / CA / 6889 / 80(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107491.11708A / turkey / TX / 28737 / 81(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ 107493.11709A / turkey / MN / 511 / 78(H9N2) matrix protein 1 (M) and matrix protein 2 (M)DQ107490.11710A / turkey / Beit Herut / 1267 / 03(H9N2) hemagglutininDQ104485.11711A / turkey / Beit HaLevi / 1009 / 02(H9N2) hemagglutininDQ104473.11712A / turkey / Beit Herut / 1265 / 03(H9N2) hemagglutininDQ104456.11713A / turkey / Beit_HaLevi / 1562 / 03(H9N2) nucleoproteinDQ116515.11714A / turkey / Beit_HaLevi / 1566 / 04(H9N2) nucleoproteinDQ116517.11715A / turkey / Beit_HaLevi / 1562 / 03(H9N2) neuraminidaseDQ116083.11716A / turkey / Beit_HaLevi / 1566 / 04(H9N2) neuraminidaseDQ116084.11717A / turkey / Beit_Herut / 1267 / 03(H9N2) neuraminidaseDQ116070.11718A / turkey / Beit_Herut / 1265 / 03(H9N2) neuraminidaseDQ116069.11719A / turkey / Beit HaLevi / 1566 / 04(H9N2) hemagglutininDQ108917.11720A / turkey / Bezat / 89 / 05(H9N2) hemagglutininDQ108922.11721A / turkey / Brosh / 1276 / 03(H9N2) hemagglutininDQ104458.11722A / turkey / Brosh / 1276 / 03(H9N2) neuraminidaseDQ116071.11723A / turkey / Emek Hefer / 1272 / 03(H9N2) hemagglutininDQ104475.11724A / turkey / Ein Habsor / 1804 / 04(H9N2) hemagglutininDQ108924.11725A / turkey / Ein Tzurim / 1172 / 02(H9N2) hemagglutininDQ104451.11726A / turkey / Ein Tzurim / 1738 / 04(H9N2) hemagglutininDQ108920.11727A / turkey / Ein_Tzurim / 1738 / 04(H9N2) neuraminidaseDQ116085.11728A / turkey / Gyvat Haim Ehud / 1544 / 03(H9N2)hemagglutininDQ108913.11729A / turkey / Givat Haim / 810 / 01 (H9N2) hemagglutininDQ104466.11730A / turkey / Givat Haim / 810 / 01 (H9N2) nucleoproteinDQ116526.11731A / turkey / Givat Haim / 868 / 02(H9N2) hemagglutininDQ104471.11732A / turkey / Givat Haim / 622 / 02(H9N2) hemagglutininDQ104462.11733A / turkey / Givat_Haim / 965 / 02(H9N2) nucleoproteinDQ116498.11734A / turkey / Gyvat_Haim_Ehud / 1544 / 03(H9N2) nucleoproteinDQ116513.11735A / turkey / Gyvat_Haim_Ehud / 1544 / 03(H9N2) neuraminidaseDQ116082.11736A / tk / Givat_Haim / 810 / 25.12.01 (H9N2) neuraminidaseDQ116063.11737A / turkey / Givat_Haim / 622 / 02(H9N2)) neuraminidaseDQ116060.11738A / turkey / Givat_Haim / 965 / 02(H9N2) neuraminidaseDQ116057.11739A / turkey / Hod_Ezyon / 699 / 02(H9N2) neuraminidaseDQ 116062.11740A / turkey / Mishmar Hasharon / 619 / 02 (H9N2) hemagglutininDQ104461.11741A / turkey / Mishmar_Hasharon / 619 / 02(H9N2) neuraminidaseDQ116059.11742A / turkey / Kfar_Vitkin / 616 / 02(H9N2) neuraminidaseDQ116058.11743A / turkey / Kfar Vitkin / 616 / 02 (H9N2) hemagglutininDQ104460.11744A / turkey / Kfar Vitkin / 615 / 02 (H9N2)hemagglutininDQ104459.11745A / turkey / Kfar Vitkin / 615 / 02 (H9N2) nucleoproteinDQ116520.11746A / turkey / Kfar_Vitkin / 616 / 02(H9N2)) nucleoproteinDQ116521.11747A / turkey / Kfar Warburg / 1224 / 03(H9N2) hemagglutininDQ104455.11748A / tk / Kfar_Vitkin / 615 / 02(H9N)) neuraminidaseDQ116067.11749A / turkey / Mishmar_Hasharon / 619 / 02(H9N2) nucleoproteinDQ116522.11750A / turkey / Naharia / 1013 / 02(H9N2) hemagglutininDQ104449.11751A / turkey / Nahalal / 1547 / 04(H9N2) hemagglutininDQ108932.11752A / turkey / Neve Ilan / 90710 / 00 (H9N2) nucleoproteinDQ116529.11753A / tk / Neve_Ilan / 90710 / 00(H9N2) neuraminidaseDQ116066.11754A / turkey / Qevuzat_Yavne / 1242 / 03(H9N2) neuraminidaseDQ116086.11755A / turkey / Sapir / 1199 / 02(H9N2) hemagglutininDQ104452.11756A / turkey / Shadmot Dvorah / 1567 / 04(H9N2) nucleoproteinDQ116518.11757A / turkey / Shadmot Dvorah / 1567 / 04(H9N2) hemagglutininDQ108918.11758A / turkey / Tzur Moshe / 1565 / 04(H9N2) nucleoproteinDQ116516.11759A / turkey / Tzur Moshe / 1565 / 04(H9N2) hemagglutininDQ108916.11760A / turkey / Yedidia / 625 / 02 (H9N2) hemagglutininDQ104463.11761A / turkey / Yedidia / 625 / 02 (H9N2) nucleoproteinDQ116523.11762A / turkey / Yedidia / 625 / 02 (H9N2) neuraminidaseDQ116061.11763A / turkey / Yedidia / 911 / 02(H9N2) hemagglutininDQ104448.11764A / turkey / Avigdor / 1215 / 03(H9N2) hemagglutininDQ104454.11765A / turkey / Avigdor / 1209 / 03(H9N2) hemagglutininDQ104453.11766A / turkey / Avichail / 1075 / 02(H9N2) hemagglutininDQ104450.11767A / turkey / Avigdor / 1920 / 04(H9N2) hemagglutininDQ108926.11768A / pintail / Alberta / 49 / 2003(H9N5) matrix protein 1 (M) and matrix protein 2 (M)DQ107498.11769A / red knot / Delaware / 2552 / 87 (H9N5) nonfunctional matrix proteinAY664472.11770A / duck / Hong Kong / 147 / 77(H9N6) hemagglutinin precursorAY206671.11771A / shorebird / Delaware / 270 / 2001(H9N7) matrix protein 1 (M) and matrix protein 2 (M)DQ107504.11772A / shorebird / Delaware / 277 / 2000(H9N7) matrix protein 1 (M) and matrix protein 2 (M)DQ107507.11773A / shorebird / Delaware / 275 / 2001(H9N7)) matrix protein 2 (M) and matrix protein 1 (M)DQ107506.11774A / ruddy turnstone / Delaware / 116 / 98 (H9N8) nonfunctional matrix proteinAY664435.11775A / shorebird / Delaware / 141 / 2002(H9N9) matrix protein 1 (M) and matrix protein 2 (M)DQ107503.11776A / ruddy turnstone / Delaware / 103 / 2002(H9N9) matrix protein 1 (M) and matrix protein 2 (M)DQ107502.11777A / shorebird / Delaware / 29 / 2002(H9N9) matrix protein 1 (M) and matrix protein 2 (M)DQ107501.11778A / shorebird / Delaware / 18 / 2002(H9N9) matrix protein 1 (M) and matrix protein 2 (M)DQ107500.11779A / ruddy turnstone / Delaware / 259 / 98 (H9N9) nonfunctional matrix proteinAY664469.1 H10N ∗< 1780A / duck / Eastern China / 527 / 2003(H10N3) segment 6 neuraminidase (NA)EU429716.11781A / duck / Eastern China / 495 / 2003(H10N3) segment 6 neuraminidase (NA)EU429715.11782A / duck / Eastern China / 372 / 2003(H10N3) segment 6 neuraminidase (NA)EU429714.11783A / duck / Eastern China / 488 / 2003(H10N3) segment 6 neuraminidase (NA)EU429712.11784A / duck / Eastern China / 453 / 2002(H10N3) segment 6 neuraminidase (NA)EU429711.11785A / duck / Eastern China / 412 / 2003(H10N3) segment 6 neuraminidase (NA)EU429710.11786A / duck / Eastern China / 404 / 2003(H10N3) segment 6 neuraminidase (NA)EU429709.11787A / duck / Eastern China / 397 / 2003(H10N3) segment 6 neuraminidase (NA)EU429708.11788A / duck / Eastern China / 502 / 2003(H10N3) segment 6 neuraminidase (NA)EU429705.11789A / duck / Eastern China / 395 / 2003(H10N3) segment 6 neuraminidase (NA)EU429704.11790A / duck / Eastern China / 356 / 2003(H10N3) segment 6 neuraminidase (NA)EU429703.11791A / duck / Eastern China / 368 / 2003(H10N3) segment 6 neuraminidase (NA)EU429702.11792A / chicken / Singapore / 1993(H10N5) M2 proteinEU014145.11793A / red knot / Delaware / 2561 / 87 (H10N5) nonfunctional matrix proteinA Y664441.11794A / chicken / Germany / N / 1949(H10N7) segment 6 neuraminidase (NA)EU429796.11795A / ruddy turnstone / Delaware / 2764 / 87 (H10N7) nonfunctional matrix proteinAY664462.11796A / mallard / Alberta / 71 / 98 (H10N7) nonfunctional matrix proteinA Y664485.11797A / mallard / Alberta / 90 / 97 (H10N7) nonfunctional matrix proteinAY664446.11798A / mallard / Alberta / 110 / 99(H10N7) nonfunctional matrix proteinAY664481.11799A / mallard / Alberta / 297 / 77 (H10N7) nonfunctional matrix proteinA Y664430.11800A / mallard / Alberta / 223 / 98 (H10N8) nonfunctional matrix proteinA Y664486.1 H11N ∗< 1801A / ruddy turnstone / New Jersey / 51 / 85 (H11N1) nonfunctional matrix proteinAY664479.11802A / duck / Nanchang / 1749 / 1992(H11N2) nucleoprotein (NP)U49094.11803A / duck / Hong Kong / 62 / 1976(H11N2) polymerase (PB1)U48280.11804A / duck / Yangzhou / 906 / 2002(H11N2) hemagglutininDQ080993.11805A / shorebird / Delaware / 86 / 99 (H11N2) nonfunctional matrix proteinA Y664463.11806A / ruddy turnstone / Delaware Bay / 2762 / 1987(H11N2)polymerase PB2 (PB2)CY126279.11807A / ruddy turnstone / Delaware / 2762 / 87 (H11N2) nonfunctional matrix proteinAY664459.11808A / ruddy turnstone / Delaware Bay / 2762 / 1987(H11N2) polymerase PB 1 (PB1) and PB1-F2 protein (PB1-F2)CY126278.11809A / ruddy turnstone / Delaware / 2589 / 87 (H11N4) nonfunctional matrix proteinAY664478.11810A / duck / England / 1 / 1956(H11N6) segment 6 neuraminidase (NA)EU429795.11811A / mallard / Alberta / 125 / 99 (H11N6) nonfunctional matrix proteinA Y664483.11812A / duck / Memphis / 546 / 1974(H11N9) segment 6 neuraminidase (NA)EU429798.11813A / mallard / Alberta / 122 / 99 (H11N9) nonfunctional matrix proteinAY664444.1 H12N ∗< 1814A / Mallard Duck / Alberta / 342 / 83(H12N1) segment 4 hemagglutinin (HA1)AF310991.11815A / ruddy turnstone / Delaware / 67 / 98(H12N4) nonfunctional matrix proteinAY664470.11816A / Ruddy Turnstone / Delaware / 67 / 98(H12N4) segment 4 hemagglutinin (HA1)AF310990.11817A / mallard / Alberta / 52 / 97 (H12N5) nonfunctional matrix proteinA Y664448.11818A / mallard / Alberta / 223 / 77 (H12N5) nonfunctional matrix proteinAY664431.11819A / Laughing Gull / New Jersey / 171 / 92(H12N5) segment 4 hemagglutinin (HA1)AF310992.11820A / ruddy turnstone / Delaware / 265 / 98 (H12N8) nonfunctional matrix proteinA Y664438.1H13N *< 1821A / herring gull / New Jersey / 782 / 86 (H13N2) nonfunctional matrix proteinA Y664475.11822A / shorebird / Delaware / 224 / 97 (H13N6) nonfunctional matrix proteinAY664421.1 other 1823A / PR / 8 / 34 (H1N1) x A / England / 939 / 69 (H3N2) PB1 proteinAJ564806.11824A / PR / 8 / 34 (H1N1) x A / England / 939 / 69 (H3N2)PB2 proteinAJ564804.11825A / duck / Czechslovakia / 56(H4N6) x A / USSR / 90 / 77(H1N1)) neuraminidase (NA)EU643639.11826A / duck / Czechslovakia / 56(H4N6) x A / USSR / 90 / 77(H1N1)) neuraminidase (NA)EU643638.11827A / duck / Ukraine / 63(H3N8) x A / USSR / 90 / 77(H1N1)) neuraminidase (NA)EU643637.11828A / duck / Ukraine / 63(H3N8) x A / USSR / 90 / 77(H1N1)) neuraminidase (NA)EU643636.11829RCB1-XXI: A / USSR / 90 / 77(H1N1)xA / Duck / Czechoslov 56 (H4N6) segment 4 hemagglutininAF290438.11830RCB1: A / USSR / 90 / 77(H1N1)xA / Duck / Czechoslov 56 (H4N6) hemagglutininAF290437.11831PX14-XIII (A / USSR / 90 / 77(H1N1)xA / Pintail Duck / Primorie / 695 / 76(H2N3)) segment 4 hemagglutininAF290442.11832PX14(A / USSR / 90 / 77(H1N1)xA / Pintail Duck / Primorie / 695 / 76(H2N3)) segment 4 hemagglutininAF290441.11833PX8-XIII(A / USSR / 90 / 77(H1N1)xA / Pintail Duck / Primorie / 695 / 76(H2N3)) segment 4 hemagglutinin1834PX8(A / USSR / 90 / 77(H1N1)xA / Pintail Duck / Primorie / 695 / 76(H2N3)) segment 4 hemagglutininAF290439.11835A / swine / Schleswig-Holstein / 1 / 93 hemagglutinin (HA)U72669.11836A / swine / England / 283902 / 93 hemagglutinin (HA)U72668.11837A / swine / England / 195852 / 92 hemagglutinin (HA)U72667.11838A / swine / England / 117316 / 86 hemagglutinin (HA)U72666.11839A / turkey / Germany / 2482 / 90) hemagglutinin (HA)U96766.1 Table 11. Influenza B Antigens Strain / Protein GenBank Access No. B / Daeku / 47 / 97 hemagglutininAF521237.1B / Daeku / 45 / 97 hemagglutininAF521236.1B / Daeku / 10 / 97 hemagglutininAF521221.1B / Daeku / 9 / 97 hemagglutininAF521220.1B / Gyeonggi / 592 / 2005 neuraminidaseDQ231543.1B / Gyeonggi / 592 / 2005 hemagglutininDQ231538.1B / Hong Kong / 5 / 72 neuraminidaseAF305220.1B / Hong Kong / 5 / 72 hemagglutininAF305219.1B / Hong Kong / 157 / 99 hemagglutininAF387503.1B / Hong Kong / 157 / 99 hemagglutininAF387502.1B / Hong Kong / 156 / 99 hemagglutininAF387501.1B / Hong Kong / 156 / 99 hemagglutininAF387500.1B / Hong Kong / 147 / 99 hemagglutininAF387499.1B / Hong Kong / 147 / 99 hemagglutininAF387498.1B / Hong Kong / 110 / 99 hemagglutininAF387497.1B / Hong Kong / 110 / 99 hemagglutininAF387496.1B / Incheon / 297 / 2005 hemagglutininDQ231539.1B / Incheon / 297 / 2005 neuraminidaseDQ231542.1B / Lee / 40 polymerase protein (PB1)D00004.1B / Michigan / 22572 / 99 hemagglutininA Y129961.1B / Michigan / 22723 / 99 hemagglutinin (HA)A Y112992.1B / Michigan / 22631 / 99 hemagglutinin (HA)AY112991.1B / Michigan / 22587 / 99 hemagglutinin (HA)A Y112990.1B / New York / 20139 / 99 hemagglutininA Y129960.1B / Panama / 45 / 90 nucleoproteinAF005739.1B / Panama / 45 / 90 polymerase (PA)AF005738.1B / Panama / 45 / 90 polymerase (PB2)AF005737.1B / Panama / 45 / 90 polymerase (PB 1)AF005736.1B / Pusan / 250 / 99 hemagglutininAF521218.1B / Pusan / 255 / 99 hemagglutininAF521226.1B / Pusan / 270 / 99 hemagglutininAF521219.1B / Pusan / 285 / 99 hemagglutininAF521217.1B / Riyadh / 01 / 2007 segment 8 nuclear export protein (NEP) and non structural protein 1 (NS1)GU135839.1B / Seoul / 6 / 88 hemagglutininAF521238.1B / Seoul / 12 / 88 hemagglutininAF521239.1B / Seoul / 1 / 89 hemagglutininAF521230.1B / Seoul / 37 / 91 hemagglutininAF521229.1B / Seoul / 38 / 91 hemagglutininAF521227.1B / Seoul / 40 / 91 hemagglutininAF521235.1B / Seoul / 41 / 91 hemagglutininAF521228.1B / Seoul / 13 / 95 hemagglutininAF521225.1B / Seoul / 12 / 95 hemagglutininAF521223.1B / Seoul / 17 / 95 hemagglutininAF521222.1B / Seoul / 21 / 95 hemagglutininAF521224.1B / Seoul / 16 / 97 hemagglutininAF521233.1B / Seoul / 19 / 97 hemagglutininAF521231.1B / Seoul / 28 / 97 hemagglutininAF521234.1B / Seoul / 31 / 97 hemagglutininAF521232.1B / Seoul / 232 / 2004 neuraminidaseDQ231541.1B / Seoul / 1163 / 2004 neuraminidaseDQ231540.1B / Seoul / 1163 / 2004 hemagglutininDQ231537.1B / Sichuan / 379 / 99 hemagglutinin (HA)AF319590.1B / Sichuan / 38 / 2000 hemagglutinin (HA)AF319589.1B / South Carolina / 25723 / 99 hemagglutininAY129962.1B / Switzerland / 4291 / 97 hemagglutininAF387505.1B / Switzerland / 4291 / 97 hemagglutininAF387504.1B / Taiwan / 21706 / 97 nonstructural protein 1 (NS1)AF492479.1B / Taiwan / 21706 / 97 hemagglutinin (HA)AF026162.1B / Taiwan / 3143 / 97 nonstructural protein 1 (NS1)AF492478.1B / Taiwan / 3143 / 97 haemagglutinin (HA)AF026161.1B / Taiwan / 2026 / 99 nonstructural protein 1 (NS 1)AF492481.1B / Taiwan / 2026 / 99 hemagglutininAY604741.1B / Taiwan / 2027 / 99 nonstructural protein 1 (NS1)AF492480.1B / Taiwan / 2027 / 99 hemagglutininAY604742.1B / Taiwan / 1243 / 99 nonstructural protein NS1(NS1)AF380504.1B / Taiwan / 1243 / 99 hemagglutininAY604740.1B / Taiwan / 2195 / 99 hemagglutininA Y604743.1B / Taiwan / 2195 / 99 nonstructural protein 1 (NS1)AF492482.1B / Taiwan / 1293 / 2000 nonstructural protein NS1(NS1)AF380509.1B / Taiwan / 1293 / 00 hemagglutininAY604746.1B / Taiwan / 1293 / 2000 hemagglutinin (HA)AF492477.1B / Taiwan / 1265 / 2000 nonstructural protein NS1 (NS1)AF380508.1B / Taiwan / 1265 / 00 hemagglutininA Y604745.1B / Taiwan / 4184 / 2000 nonstructural protein NS1 (NS1)AF380507.1B / Taiwan / 4184 / 00 hemagglutinin (HA)A Y604750.1B / Taiwan / 31511 / 2000 nonstructural protein NS 1 (NS 1)AF380505.1B / Taiwan / 31511 / 00 hemagglutinin (HA)A Y604748.1B / Taiwan / 12192 / 2000 hemagglutininAY604747.1B / Taiwan / 41010 / 00 hemagglutinin (HA)AY604749.1B / Taiwan / 41010 / 2000 nonstructural protein NS 1 (NS 1)AF380506.1B / Taiwan / 0409 / 00 hemagglutinin (HA)AY604744.1B / Taiwan / 202 / 2001 nonstructural protein 1 (NS1)AF380512.1B / Taiwan / 202 / 2001 hemagglutinin (HA)AF366076.1B / Taiwan / 11515 / 2001 nonstructural protein 1 (NS1)AF380511.1B / Taiwan / 11515 / 01 hemagglutininAY604754.1B / Taiwan / 11515 / 2001 hemagglutinin (HA)AF366075.1B / Taiwan / 1103 / 2001 nonstructural protein NS1 (NS1)AF380510.1B / Taiwan / 1103 / 01 hemagglutininA Y604755.1B / Taiwan / 114 / 2001 hemagglutinin (HA), HA-4 alleleAF492476.1B / Taiwan / 2805 / 2001 hemagglutinin (HA)AF400581.1B / Taiwan / 2805 / 01 hemagglutinin (HA)AY604752.1B / Taiwan / 0114 / 01 hemagglutinin (HA)A Y604753.1B / Taiwan / 0202 / 01 hemagglutinin (HA)AY604751.1B / Taiwan / 4119 / 02 hemagglutinin (HA)AY604778.1B / Taiwan / 4602 / 02 hemagglutinin (HA)AY604777.1B / Taiwan / 1950 / 02 hemagglutinin (HA)AY604776.1B / Taiwan / 1949 / 02 hemagglutinin (HA)AY604775.1B / Taiwan / 1584 / 02 hemagglutinin (HA)AY604774.1B / Taiwan / 1561 / 02 hemagglutinin (HA)AY604773.1B / Taiwan / 1536 / 02 hemagglutinin (HA)AY604772.1B / Taiwan / 1534 / 02 hemagglutinin (HA)AY604771.1B / Taiwan / 1503 / 02 hemagglutinin (HA)AY604770.1B / Taiwan / 1502 / 02 hemagglutinin (HA)AY604769.1B / Taiwan / 1013 / 02 hemagglutinin (HA)A Y604768.1B / Taiwan / 0993 / 02 hemagglutinin (HA)AY604766.1B / Taiwan / 0932 / 02 hemagglutinin (HA)A Y604765.1B / Taiwan / 0927 / 02 hemagglutinin (HA)AY604764.1B / Taiwan / 0880 / 02 hemagglutinin (HA)A Y604763.1B / Taiwan / 0874 / 02 hemagglutinin (HA)AY604762.1B / Taiwan / 0730 / 02 hemagglutinin (HA)A Y604761.1B / Taiwan / 0722 / 02 hemagglutinin (HA)AY604760.1B / Taiwan / 0702 / 02 hemagglutinin (HA)AY604759.1B / Taiwan / 0654 / 02 hemagglutinin (HA)AY604758.1B / Taiwan / 0600 / 02 hemagglutinin (HA)AY604757.1B / Taiwan / 0409 / 02 hemagglutinin (HA)A Y604756.1B / Taiwan / 0879 / 02 nonfunctional hemagglutininAY604767.1B / Taiwan / 3532 / 03 hemagglutinin (HA)AY604794.1B / Taiwan / 2551 / 03 hemagglutinin (HA)A Y604793.1B / Taiwan / 1618 / 03 hemagglutinin (HA)AY604792.1B / Taiwan / 1574 / 03 hemagglutinin (HA)AY604791.1B / Taiwan / 1013 / 03 hemagglutinin (HA)AY604790.1B / Taiwan / 0833 / 03 hemagglutinin (HA)AY604789.1B / Taiwan / 0735 / 03 hemagglutinin (HA)A Y604788.1B / Taiwan / 0699 / 03 hemagglutinin (HA)AY604787.1B / Taiwan / 0684 / 03 hemagglutinin (HA)AY604786.1B / Taiwan / 0616 / 03 hemagglutinin (HA)AY604785.1B / Taiwan / 0615 / 03 hemagglutinin (HA)AY604784.1B / Taiwan / 0610 / 03 hemagglutinin (HA)A Y604783.1B / Taiwan / 0576 / 03 hemagglutinin (HA)AY604782.1B / Taiwan / 0569 / 03 hemagglutinin (HA)A Y604781.1B / Taiwan / 0562 / 03 hemagglutinin (HA)AY604780.1B / Taiwan / 0002 / 03 hemagglutinin (HA)AY604779.1B / Taiwan / 773 / 2004 hemagglutinin (HA)EU068195.1B / Taiwan / 187 / 2004 hemagglutinin (HA)EU068194.1B / Taiwan / 3892 / 2004 hemagglutinin (HA)EU068193.1B / Taiwan / 562 / 2004 hemagglutinin (HA)EU068191.1B / Taiwan / 234 / 2004 hemagglutinin (HA)EU068188.1B / Taiwan / 4897 / 2004 hemagglutinin (HA)EU068186.1B / Taiwan / 8579 / 2004 hemagglutinin (HA)EU068184.1B / Taiwan / 184 / 2004 hemagglutinin (HA)EU068183.1B / Taiwan / 647 / 2005 hemagglutinin (HA)EU068196.1B / Taiwan / 877 / 2005 hemagglutinin (HA)EU068198.1B / Taiwan / 521 / 2005 hemagglutinin (HA)EU068189.1B / Taiwan / 1064 / 2005 hemagglutinin (HA)EU068192.1B / Taiwan / 3722 / 2005 hemagglutinin (HA)EU068197.1B / Taiwan / 5049 / 2005 hemagglutinin (HA)EU068190.1B / Taiwan / 5011 / 2005 hemagglutinin (HA)EU068187.1B / Taiwan / 4659 / 2005 hemagglutinin (HA)EU068185.1B / Taiwan / 25 / 2005 hemagglutinin (HA)EU068182.1B / Taiwan / 1037 / 2005 hemagglutinin (HA)EU068181.1B / Taiwan / 62 / 2005 hemagglutinin (HA)EU068180.1B / Taiwan / 591 / 2005 hemagglutinin (HA)EU068179.1B / Taiwan / 649 / 2005 hemagglutinin (HA)EU068178.1B / Taiwan / 4554 / 2005 hemagglutinin (HA)EU068177.1B / Taiwan / 987 / 2005 hemagglutinin (HA)EU068176.1B / Taiwan / 2607 / 2006 hemagglutinin (HA)EU068175.1B / Vienna / 1 / 99 hemagglutininAF387495.1B / Vienna / 1 / 99 hemagglutininAF387494.1B / Vienna / 1 / 99 hemagglutininAF387493.1B / Vienna / 1 / 99 hemagglutininAF387492.1 Table 12. Influenza C Antigens Strain / Protein GenBank Access No. C / JHB / 1 / 66) hemagglutinin-esterase-fusion protein (HEF) mRNA, complete cds.AY880247.1STRAIN C / ANN ARBOR / 1 / 50) persistent variant segment 7 non-structural protein 1 (NS1) mRNA, complete cdsAF102027.1(STRAIN C / ANN ARBOR / 1 / 50) wild type segment 7 non-structural protein 1 (NS1) mRNA, complete cdsAF102026.1(C / JHB / 1 / 66) hemagglutinin-esterase-fusion protein (HEF) mRNA, complete cdsAY880247.1(STRAIN C / BERLIN / 1 / 85) mRNA for basic polymerase 2 precursorX55992.1 Table 13: H7 Hemagglutinin Amino Acid Sequences SEQ ID NOAccession No / Strain / ProteinAmino Acid Sequence2284AAM19228 A / turkey / Minne sota / 38429 / 1988 1988 / / HA 203350172285AAY46211 A / mallard / Swed en / 91 / 2002 2002 / / HA 663948282286ABI84694 A / turkey / Minne sota / 1 / 1988 1988 / 07 / 13 HA 1152785732287ABS89409 A / blue-winged teal / Ohio / 566 / 20 06 2006 / / HA 1550163242288ACD03594 A / ruddy turnstone / DE / 15 38 / 2000 2000 / / HA 1873848482289BAH22785 A / duck / Mongoli a / 119 / 2008 2008 / / HA 2237178202290CA Y39406 A / Anas crecca / Spain / 14 60 / 2008 2008 / 01 / 26 HA 2546743762291ACX53683 A / goose / Czech Republic / 1848-K9 / 2009 2009 / 02 / 04 HA 2609077632292ACZ48625 A / turkey / Minne sota / 38429 / 1988 1988 / / HA 2698263412293ADC29485 A / mallard / Spain / 08.00991.3 / 200 5 2005 / 11 / HA 2849273362294ADK71137 A / blue-winged teal / Guatemala / CIP049-01 / 2008 2008 / 02 / 07 HA 3013337852295ADK71148 A / blue-winged teal / Guatemala / CIP049-02 / 2008 2008 / 03 / 05 HA 3013338042296ADN34727 A / goose / Czech Republic / 1848-T14 / 2009 2009 / 02 / 04 HA 3071418692297AEK84760 A / wild bird / Korea / A14 / 2011 2011 / 02 / HA 3416103082298AEK84761 A / wild bird / Korea / A3 / 2 011 2011 / 02 / HA 3416103102299AEK84763 A / wild bird / Korea / A9 / 2 011 2011 / 02 / HA 3416103142300AEK84765 A / spot-billed duck / Korea / 447 / 2011 2011 / 04 / HA 3416103182301AEM98291 A / wild duck / Mongolia / 1-241 / 2008 2008 / 04 / HA 3441961202302AFM09439 A / emperor goose / Alaska / 44 063-061 / 2006 2006 / 05 / 23 HA 3905350622303AFV33945 A / guinea fowl / Nebraska / 1 7096-1 / 2011 2011 / 04 / 05 HA 4096768202304AFV33947 A / goose / Nebras ka / 17097-4 / 2011 2011 / 04 / 05 HA 4096768272305AFX85260 A / ruddy turnstone / Delaw are Bay / 220 / 1995 1995 / 05 / 21 HA 4235149122306AGE08098 A / northern shoverl / Mississi ppi / 11OS 145 / 20 11 2011 / 01 / 08 HA 4443444882307AGI60301 A / Hangzhou / 1 / 2 013 2013 / 03 / 24 HA 4756624542308AGI60292 A / Shanghai / 466 4T / 2013 2013 / 03 / 05 HA 4764035602309AGJ72861 A / chicken / Zheji ang / DTID-ZJU01 / 2013 2013 / 04 / HA 4792802942310AGJ73503 A / Nanjing / 1 / 201 3 2013 / 03 / 28 HA 4792857612311BAN16711 A / duck / Gunma / 466 / 2011 2011 / / HA 4826615712312AGK84857 A / Hangzhou / 2 / 2 013 2013 / 04 / 01 HA 4856498242313AGL44438 A / Shanghai / 02 / 2 013 2013 / 03 / 05 HA 4964933892314AGL33692 A / Shanghai / 465 5T / 2013 2013 / 02 / 26 HA 4918741752315AGL33693 A / Shanghai / 465 9T / 2013 2013 / 02 / 27 HA 4918741862316AGL95088 A / Taiwan / S020 76 / 2013 2013 / 04 / 22 HA 5014853012317AGL95098 A / Taiwan / T020 81 / 2013 2013 / 04 / 22 HA 5014853192318AGM53883 A / Shanghai / 508 3T / 2013 2013 / 04 / 20 HA 5075939862319AGM53884 A / Shanghai / 518 0T / 2013 2013 / 04 / 23 HA 5075939882320AGM53885 A / Shanghai / 524 0T / 2013 2013 / 04 / 25 HA 5075939902321AGM53886 A / Shanghai / 484 2T / 2013 2013 / 04 / 13 HA 5075939922322AGM53887 A / Shanghai / 470 1T / 2013 2013 / 04 / 06 HA 5075939942323AGN69462 A / Wuxi / 2 / 2013 2013 / 03 / 31 HA 5111057782324AGN69474 A / Wuxi / 1 / 2013 2013 / 03 / 31 HA 5111057982325AGO51387 A / Jiangsu / 2 / 201 3 2013 / 04 / 20 HA 5143909902326BAN59726 A / duck / Mongoli a / 147 / 2008 2008 / 08 / 29 HA 5196619512327BAN59727 A / duck / Mongoli a / 129 / 2010 2010 / / HA 5196619542328AGQ80952 A / duck / Jiangxi / 3096 / 2009 2009 / / HA 5237887942329AGQ80989 A / duck / Jiangxi / 3257 / 2009 2009 / / HA 5237888682330AGQ81043 A / chicken / Rizha o / 515 / 2013 2013 / / HA 5237889762331AGR33894 A / chicken / Rizha o / 719b / 2013 2013 / / HA 5248452132332AGR49399 A / chicken / Jiang xi / SD001 / 2013 2013 / 05 / 03 HA 5253385282333AGR49495 A / chicken / Shan ghai / S1358 / 201 3 2013 / 04 / 03 HA 5253386892334AGR49506 A / chicken / Shan ghai / S 1410 / 201 3 2013 / 04 / 03 HA 5253387082335AGR49554 A / chicken / Zheji ang / SD033 / 2013 2013 / 04 / 11 HA 5253387892336AGR49566 A / duck / Anhui / S C702 / 2013 2013 / 04 / 16 HA 5253388092337AGR49722 A / homing pigeon / Jiangsu / SD184 / 2013 2013 / 04 / 20 HA 5253390712338AGR49734 A / pigeon / Shang hai / S1069 / 2013 2013 / 04 / 02 HA 5253390912339AGR49770 A / wild pigeon / Jiangsu / SD001 / 2013 2013 / 04 / 17 HA 5253391512340AGY41893 A / Huizhou / 01 / 2 013 2013 / 08 / 08 HA 5520494962341AGY42258 A / mallard / Swed en / 91 / 2002 2002 / 12 / 12 HA 5520521552342AHA11441 A / guinea fowl / Nebraska / 1 7096 / 2011 2011 / 04 / 10 HA 5574785722343AHA11452 A / turkey / Minne sota / 32710 / 2011 2011 / 07 / 12 HA 5574785912344AHA11461 A / turkey / Minne sota / 31900 / 2011 2011 / 07 / 05 HA 5574786062345AHK10585 A / chicken / Guan gdong / G 1 / 2013 2013 / 05 / 05 HA 5876806362346AGG53366 A / wild duck / Korea / CS M42-34 / 2011 2011 / 03 / HA 4592528872347AGG53377 A / wild duck / Korea / CS M42-1 / 2011 2011 / 03 / HA 4592529252348AGG53399 A / wild duck / Korea / MH C39-26 / 2011 2011 / 03 / HA 4592530052349AGG53432 A / wild duck / Korea / MH C35-41 / 2011 2011 / 03 / HA 4592531362350AGG53476 A / wild duck / Korea / SH1 9-27 / 2010 2010 / 12 / HA 4592532572351AGG53487 A / wild duck / Korea / SH1 9-50 / 2010 2010 / 01 / HA 4592532782352AGG53520 A / wild duck / Korea / SH2 0-27 / 2008 2008 / 12 / HA 4592534092353AGL43637 A / Taiwan / 1 / 201 3 2013 / / HA 4962973892354AGL97639 A / mallard / Minn esota / AI09-3770 / 2009 2009 / 09 / 12 HA 5055553712355AGO02477 A / Xuzhou / 1 / 201 3 2013 / 04 / 25 HA 5124036882356AGR84942 A / Suzhou / 5 / 201 3 2013 / 04 / 12 HA 5263045612357AGR84954 A / Nanjing / 6 / 201 3 2013 / 04 / 11 HA 5263045942358AGR84978 A / Wuxi / 4 / 2013 2013 / 04 / 07 HA 5263046562359AGR84990 A / Wuxi / 3 / 2013 2013 / 04 / 07 HA 5263046882360AGR85002 A / Zhenjiang / 1 / 2 013 2013 / 04 / 07 HA 5263047082361AGR85026 A / N anjing / 2 / 201 3 2013 / 04 / 05 HA 5263047622362AGU02230 A / Zhejiang / DTI D-ZJU05 / 2013 2013 / 04 / HA 5328087652363AGU02233 A / Zhejiang / DTI D-ZJU08 / 2013 2013 / 04 / HA 5328087882364AGW82588 A / tree sparrow / Shangh ai / 01 / 2013 2013 / 05 / 09 HA 5462353482365AGW82600 A / Shanghai / CN 01 / 2013 2013 / 04 / 11 HA 5462353682366AGW82612 A / Shanghai / JSO 1 / 2013 2013 / 04 / 03 HA 5462353882367AHA11472 A / turkey / Minne sota / 31676 / 2009 2009 / 12 / 08 HA 5574786252368AHA11483 A / turkey / Minne sota / 14135-2 / 2009 2009 / 08 / 07 HA 5574786442369AHA11500 A / Zhejiang / DTI D-ZJU10 / 2013 2013 / 10 / 14 HA 5574786762370AHA57050 A / turkey / Minne sota / 14659 / 2009 2009 / 08 / 12 HA 5584844272371AHA57072 A / turkey / Minne sota / 18421 / 2009 2009 / 09 / 09 HA 5584844652372AHD25003 A / Guangdong / 0 2 / 2013 2013 / 10 / HA 5682605672373AHF20528 A / Hong Kong / 470129 / 20 13 2013 / 11 / 30 HA 5709335552374AHF20568 A / Shanghai / CN 02 / 2013 2013 / 04 / 02 HA 5709336262375AHH25185 A / Guangdong / 0 4 / 2013 2013 / 12 / 16 HA 5761062342376AHJ57411 A / Shanghai / PD-01 / 2014 2014 / 01 / 17 HA 5854780412377AHJ57418 A / Shanghai / PD-02 / 2014 2014 / 01 / 17 HA 5854782562378AHK10800 A / Shanghai / 01 / 2 014 2014 / 01 / 03 HA 5876810142379AHM24224 A / Beijing / 3 / 201 3 2013 / 04 / 16 HA 5947048022380AHN96472 A / chicken / Shan ghai / PD-CN - 02 / 2014 2014 / 01 / 21 HA 6027016412381AHZ39686 A / Anhui / DEWH 72-01 / 2013 2013 / / HA 6328070362382AHZ39710 A / Anhui / DEWH 72-03 / 2013 2013 / / HA 6328070762383AHZ39746 A / Anhui / DEWH 72-06 / 2013 2013 / / HA 6328071362384AHZ41929 A / mallard / Swed en / 1621 / 2002 2002 / 12 / 12 HA 6328109492385AHZ42537 A / mallard / Minn esota / AI09-3770 / 2009 2009 / 09 / 12 HA 6328119642386AHZ42549 A / ruddy turnstone / Delaw are / AI00-1538 / 2000 2000 / 05 / 20 HA 6328119842387AID70634 A / Shanghai / Mix 1 / 2014 2014 / 01 / 03 HA 6603046502388AIN76383 A / Zhejiang / LSO 1 / 2014 2014 / 02 / 08 HA 6846946372368AIU46619 A / chicken / Zheji ang / DTID-ZJU06 / 2013 2013 / 12 / HA 6999789312369AIU47013 A / chicken / Suzh ou / 040201H / 201 3 2013 / 04 / HA 6999796732370AJJ90490 A / chicken / Shen zhen / 742 / 2013 2013 / 12 / 10 HA 7551780942371AJJ90526 A / chicken / Shen zhen / 898 / 2013 2013 / 12 / 09 HA 7551781542372AJJ90538 A / silkie chicken / Shenzhe n / 918 / 2013 2013 / 12 / 09 HA 7551781742373AJJ90576 A / chicken / Shen zhen / 1665 / 2013 2013 / 12 / 12 HA 7551782382374AJJ90588 A / chicken / Shen zhen / 2110 / 2013 2013 / 12 / 13 HA 7551782582375AJJ90661 A / chicken / Dong guan / 2912 / 2013 2013 / 12 / 18 HA 7551783802376AJJ90673 A / silkie chicken / Donggu an / 3049 / 2013 2013 / 12 / 18 HA 7551784002377AJJ90795 A / silkie chicken / Donggu an / 3281 / 2013 2013 / 12 / 18 HA 7551786042378AJJ90891 A / silkie chicken / Donggu an / 3520 / 2013 2013 / 12 / 19 HA 7551787642379AJJ90951 A / chicken / Dong guan / 3544 / 2013 2013 / 12 / 19 HA 7551788642380AJJ91035 A / chicken / Shen zhen / 3780 / 2013 2013 / 12 / 19 HA 7551790042381AJJ91155 A / chicken / Dong guan / 4037 / 2013 2013 / 12 / 19 HA 7551792042382AJJ92005 A / chicken / Shen zhen / 801 / 2013 2013 / 12 / 09 HA 7551806292383AJJ94254 A / chicken / Dong guan / 1374 / 2014 2014 / 02 / 21 HA 7551843822384AJJ94606 A / chicken / Dong guan / 191 / 2014 2014 / 02 / 20 HA 7551849682385AJJ96552 A / chicken / Jiang xi / 12206 / 2014 2014 / 03 / 16 HA 7551882192386AJJ96684 A / chicken / Jiang xi / 13207 / 2014 2014 / 03 / 30 HA 7551884392387AJJ96732 A / chicken / Jiang xi / 13223 / 2014 2014 / 03 / 30 HA 7551885192388AJK00354 A / duck / Zhejiang / LS02 / 2014 2014 / 01 / 12 HA 7551944692389AJJ91264 A / silkie chicken / Donggu an / 4129 / 2013 2013 / 12 / 19 HA 7551793862390AJJ91314 A / chicken / Shao xing / 2417 / 2013 2013 / 10 / 20 HA 7551794702391AJJ91402 A / chicken / Huzh ou / 4045 / 2013 2013 / 10 / 24 HA 7551796182392AJJ91476 A / chicken / Huzh ou / 4076 / 2013 2013 / 10 / 24 HA 7551797432393AJJ91725 A / chicken / Shao xing / 5201 / 2013 2013 / 10 / 28 HA 7551801612394AJJ91885 A / Shenzhen / SP4 / 2014 2014 / 01 / 16 HA 7551804292395AJJ91909 A / Shenzhen / SP2 6 / 2014 2014 / 01 / 20 HA 7551804692396AJJ91945 A / Shenzhen / SP3 8 / 2014 2014 / 01 / 22 HA 7551805292397AJJ91957 A / Shenzhen / SP4 4 / 2014 2014 / 01 / 23 HA 7551805492398AJJ91969 A / Shenzhen / SP4 8 / 2014 2014 / 01 / 23 HA 7551805692399AJJ91993 A / chicken / Dong guan / 4119 / 2013 2013 / 12 / 19 HA 7551806092400AJJ92031 A / chicken / Dong guan / 4064 / 2013 2013 / 12 / 19 HA 7551806722401AJJ92967 A / silkie chicken / Jiangxi / 9469 / 2014 2014 / 02 / 16 HA 7551822322402AJJ93027 A / chicken / Jia...

Claims

1. A nucleic acid vaccine, comprising: one or more mRNA polynucleotides having an open reading frame encoding an antigenic polypeptide, wherein the one or more mRNA polynucleotides comprise at least one chemical modification and are formulated in a lipid nanoparticle having a molar ratio of 20-60% cationic lipid: 5-25% non-cationic lipid: 25-55% sterol; and 0.5-15% PEG-modified lipid, wherein the at least one chemical modification is selected from the group consisting of pseudouridine, Nl-methylpseudouridine, 2-thiouridine, 4-thiouridine, 5-methylcytosine, 2-thio-1-methyl-1-deaza-pseudouridine, 2-thio-1-methyl-pseudouridine, 2-thio-5-aza-uridine , 2-thio-dihydropseudouridine, 2-thio-dihydrouridine, 2-thio-pseudouridine, 4-methoxy-2-thio-pseudouridine, 4-methoxy-pseudouridine, 4-thio-1-methyl-pseudouridine, 4-thio-pseudouridine, 5-aza-uridine, dihydropseudouridine, 5-methoxyuridine, 2'-O-methyl uridine, 1-carboxymethyl-pseudouridine, 1-propynyl-pseudouridine, 1-taurinomethyl-pseudouridine, 1-taurinomethyl-4-thio-pseudouridine, 3-methyl-pseudouridine (m3ψ), 1-methyl-1-deaza-pseudouridine, 2-methoxyuridine, 2-methoxy-4- thio-uridine, 1-methyl-3-(3-amino-3-carboxypropyl)pseudouridine (acp3ψ), and 2'-O-methyl-pseudouridine (ψm), wherein the antigenic polypeptide is derived from an infectious agent, wherein the infectious agent is a strain of Influenza A or Influenza B or combinations thereof and wherein the antigenic polypeptide is a hemagglutinin protein or fragment thereof.

2. The vaccine of claim 1, wherein the cationic lipid is an ionizable cationic lipid, the non-cationic lipid is a neutral lipid and the sterol is a cholesterol.

3. The vaccine of any one of claims 1-2, wherein the at least one chemical modification is a N1-methyl pseudouridine.

4. The vaccine of any one of claims 1-3, wherein the hemagglutinin protein comprises a) a portion of the head domain (HA1), b) a portion of the cytoplasmic domain, and / or c) a portion of the transmembrane domain.

5. The vaccine of claim 1, wherein the infectious agent is a virus selected from the group consisting of H1N1, H3N2, H7N9, and H10N8.

6. The vaccine of any one of claims 1-2, wherein the chemical modification is selected from the group consisting of pseudouridine, Nl-methylpseudouridine, 2-thiouridine, 4-thiouridine, 5-methylcytosine, 2-thio-1-methyl-1-deaza-pseudouridine, 2-thio-1-methyl-pseudouridine, 2-thio-5-aza-uridine , 2-thio-dihydropseudouridine, 2-thio-dihydrouridine, 2-thio-pseudouridine, 4-methoxy-2-thio-pseudouridine, 4-methoxy-pseudouridine, 4-thio-1-methyl-pseudouridine, 4-thio-pseudouridine, 5-aza-uridine, dihydropseudouridine, 5-methoxyuridine, and 2'-O-methyl uridine.

7. The vaccine of any one of claims 1-6, wherein the lipid nanoparticle has: a) a mean diameter of 50-200nm, or b) a net neutral charge at a neutral pH.

8. The vaccine of any one of claims 1-7, wherein the mRNA polynucleotide comprises a polynucleotide having at least 80% sequence identity to SEQ ID NOs 2459-2621.

9. The vaccine of any one of claims 1-7, wherein the mRNA polynucleotide comprises a polynucleotide encoding an amino acid sequence having at least 90% sequence identity to SEQ ID NO 2254, 2259, or 2624.

10. The vaccine of any one of claims 1-7, wherein the mRNA polynucleotide comprises a polynucleotide encoding the amino acid sequence of SEQ ID NO 2254, 2259, or 2624.

11. A vaccine of any one of claims 1-10 for use in a method of inducing an antigen specific immune response in a subject, the method comprising administering the vaccine to the subject in an effective amount to produce an antigen specific immune response.

12. A vaccine of any of claims 1-10 for use in a method of preventing or treating influenza viral infection, the method comprising administering the vaccine to a subject.