METHODS AND COMPOSITIONS FOR TREATING A SUBJECT WITH AN ANTISENSE OLIGONUCLEOTIDE OF SMAD7
MA43331AUndetermined Publication Date: 2017-08-23NOGRA PHARMA LTD
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Patent Information
- Application Number
- MA43331
- Authority / Receiving Office
- MA · MA
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2014-10-17
- Filing Date
- 2015-10-16
- Publication Date
- 2017-08-23
Abstract
The present invention relates to the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis) using antisense nucleotides directed against polymorphic forms (e.g., those containing single nucleotide polymorphisms) of the smad7 mRNA. The invention therefore relates to treatment methods for subjects with polymorphic forms of smad7 and to antisense oligonucleotides that specifically target smad7 mRNA transcripts containing polymorphisms.
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