Drug conjoining with a cluttered disulfide bridge

Abstract

The invention generally relates to disulfide drug conjugates in which a linker comprising a sulfur-containing carbon atom substituted with at least one hydrocarbyl or substituted hydrocarbyl is conjugated by a disulfide bond to a cysteine ​​sulfur atom of a targeting carrier, and in which the linker is further conjugated to a drug fragment. The invention further relates to activated drug linker conjugates that can be conjugated to a targeting carrier by a disulfide bond. The invention further relates to methods for preparing drug conjugates based on hindered disulfide.