Improved antigen binding receptor formats

Abstract

The present disclosure generally relates to antigen binding receptors in new formats capable of specific binding to a tumor associated antigen. More precisely, the present invention relates to an antigen binding receptor which efficiently and specifically binds to / interacts with an antigen on the surface of a tumor cell, and to a t cell transfected / transduced with the antigen binding receptor. Furthermore, the invention relates to nucleic acid molecules and vectors encoding antigen binding receptors of the present invention. The invention also provides the production and use of t cells in a method for the treatment of particular diseases as well as pharmaceutical compositions / medicaments comprising antigen binding receptors and / or t cells of the present invention.