KIF18A INHIBITORS

MA54543B1Active Publication Date: 2026-09-30AMGEN INC

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Patent Information

Application Number: MA54543
Authority / Receiving Office: MA · MA
Patent Type: Patents
Current Assignee / Owner
Priority Date: 2019-12-20
Filing Date: 2019-12-20
Publication Date: 2026-09-30
Estimated Expiration: 2039-12-20

Application Information

Patent Timeline

20 Dec 2019

Priority

20 Dec 2019

Application

MA54543

30 Sep 2026

Publication

MA54543B1

IPC: A61K31/506; A61P35/00; C07D401/12; C07D401/14; C07D405/14; C07D413/14; C07D419/14; C07D491/044

CPC: C07D401/12; C07D405/14; C07D401/14; C07D413/14; A61P35/00; C07D419/14; C07D491/044; C07D491/107

Inventors: LOW Jonathan Dante; MA Vu

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Abstract

The invention relates to compounds of formula (I): (I), as defined in the description, and synthetic intermediates thereof, which can modulate the KIF18A protein, thereby influencing the cell cycle and cell proliferation processes to treat cancer and cancer-related diseases. The invention also relates to pharmaceutical compositions comprising the compounds, and methods for treating pathological conditions related to KIF18A activity.

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Patent Information

Abstract