Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives

Abstract

The present disclosure relates to inhibitors of NLRP3 of Formula (I): (I), or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, stereoisomer, tautomer, isotopically labeled compound, or prodrug thereof, wherein Ring A is a 5- to 8-membered monocyclic heterocycloalkyl comprising at least one O ring atom, p is 0 or 1, and R1, R2, R3, R4, and X are as defined herein, useful in the treatment of diseases and disorders inhibited by said protein.