SOLUBLE FIBER COMPOSITIONS TO PREVENT FATTY LIVER AND ALZHEIMER'S.

Abstract

The present invention establishes a basis for using soluble fiber, particularly compositions comprising agave fructans, to prevent or treat the accumulation of lipids, particularly ceramides in the liver and brain, and lipofuscin in the liver, thereby improving the overall integrity of both organs. This makes it feasible to treat fatty liver disease and also to prevent Alzheimer's disease (AD). In the present invention, we analyzed alterations in lipid metabolism in the liver and ceramide production in the brain of transgenic mice (APP / PS1, TG) for AD. Our results indicate that microvesicular lipid accumulation within hepatocytes is increased in TG mice compared to the control group.Furthermore, in the brains of TG mice, a greater accumulation of ceramides was observed in the somatosensory cortex and entorhinal cortex; in the CA1 region of the hippocampus and in the motor cortex, no significant increase was observed when compared to the control group.