NEW IRIDIUM CATALYSTS FOR THE ENANTIOSELECTIVE HYDROGENATION OF 4-SUBSTITUTED 1,2-DIHYDROQUINOLINES
MX433993BActive Publication Date: 2026-05-19BAYER AG +1
Patent Information
- Authority / Receiving Office
- MX · MX
- Patent Type
- Patents
- Current Assignee / Owner
- BAYER AG
- Filing Date
- 2022-03-23
- Publication Date
- 2026-05-19
AI Technical Summary
Technical Problem
Existing methods for preparing optically active 4-substituted 1,2,3,4-tetrahydroquinolines suffer from low yield and enantioselectivity, requiring multiple processing and purification steps.
Method used
A process involving enantioselective hydrogenation of 4-substituted 1,2-dihydroquinolines using a chiral iridium (P,N) catalyst, specifically with a chiral ligand of formula (Illa) or (IIIb), achieves high yield and excellent enantioselectivity.
Benefits of technology
The process enables the preparation of optically active 4-substituted 1,2,3,4-tetrahydroquinolines with high yield and enantioselectivity, simplifying the production process.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to a process for preparing optically active 4-substituted 1,2,3,4-tetrahydroquinolines comprising the enantioselective hydrogenation of the corresponding 4-substituted 1,2-dihydroquinolines in the presence of a chiral iridium (P,N)-ligand catalyst.
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