COMPOSITIONS AND METHODS TO RESTORE THE EXPRESSION OF THE PATERNAL UBE3A GENE IN HUMAN ANGELMAN SYNDROME

Abstract

The present invention relates to compositions and methods for activating expression from the paternally inherited allele of UBE3A in human Angelman syndrome neurons using viral vector delivery of short hairpin RNAs, ribozymes and / or microRNAs.

Description

COMPOSITIONS AND METHODS TO RESTORE PATERAL UBE3A GENE EXPRESSION IN HUMAN ANGELMAN SYNDROME Cross reference to related requests This application claims priority from US Provisional Patent Application No. 62 / 734,435 filed September 21, 2018, the entire contents of which are fully incorporated herein by reference. Technical field of the invention The present disclosure relates to compositions and methods for activating expression of the paternally inherited allele of UBE3A in the neurons of humans with Angelman Syndrome using short hairpin RNAs, ribozymes, and / or microRNAs. Background of the invention Angelman syndrome (AS) is a neurodevelopmental disorder that affects -1 / 15,000 people. People with AS have developmental delay, severe cognitive impairment, ataxic gait, frequent seizures, short attention span, absence of speech, and characteristic cheerful behavior. Neurons derived from induced pluripotent stem cells (iPSCs) from patients with AS show depolarized resting membrane potential, delayed action potential development, and reduced spontaneous synoptic activity. AS affects a relatively large patient population; a contact registry with >3,000 patients has been established and -250 new SA diagnoses are made each year. People with AS require lifelong care. AS is caused by loss of function of the maternal copy of UBE3A, a gene encoding an E3 ubiquitin ligase. This loss-of-function mutation can be caused by any type of gene mutation in the maternal allele. UBE3A is expressed exclusively from the maternal allele in neurons. All people with AS have a normal paternal UBE3A allele that is epigenetically silenced by a long non-coding RNA, called the UBE3A antisense transcript (UBE3A-ATS). Reactivation of the paternal allele has been shown to restore UBE3 A protein expression and alleviate behavioral deficits in a mouse model of SA. Restoring UBE3A expression in humans is expected to improve the disease, especially if it is restored in infants. There is no cure for Angelman syndrome, however, pharmaceutical companies and academic laboratories are applying two approaches to cure this disorder. The first is the use of antisense oligonucleotides (ASOs) to cut UBE3A-ATS and activate paternal UBE3A. The second approach is AAV-mediated gene therapy to introduce the UBE3A gene back into the patient. The ASOs mentioned above do not cross the blood-brain barrier and require repeated injections into the spinal cord for life. Gene therapy to reintroduce the UBE3A gene into neurons lacks the ability to regulate UBE3A mRNA and protein levels enccnni ι 7Π7 / β / υιλι and requires the choice of a single isoform of the protein from a total of three, where the function of the individual isoforms remains uncertain. This can lead to overexpression of UBE3A, which can also contribute to another related disorder, Dup15q syndrome, and the absence of a major protein isoform. Brief description of the invention The present invention provides a novel treatment approach for AS through gene therapy by inhibiting the silencing of paternal UBE3A and enabling expression of paternal UBE3A from its parental regulatory elements. Increased expression of UBE3A in neurons can enhance the effects of UBE3A-ATS on neurons mentioned above. All three isoforms of the protein can be expressed using the endogenous regulatory elements that normally control their levels. Consequently, overexpression due to the use of original regulatory elements is avoided. This approach can improve AS symptoms through a single treatment, thus avoiding the repeated injections into the spinal cord that ASOs require. In one aspect, the invention provides a polynucleotide comprising a first nucleotide sequence encoding a short hairpin RNA (shRNA), ribozyme or microRNA, wherein the shRNA, ribozyme or microRNA is capable of inhibiting the silencing of the UBE3 To paternal. In another aspect, the invention provides an expression vector comprising the polynucleotide having the first nucleotide sequence encoding the shRNA, ribozyme or microRNA, wherein the shRNA, ribozyme or microRNA is capable of inhibiting the silencing of the UBE3 A paternal; and a promoter. In another aspect, the invention provides a viral particle comprising the polynucleotide having the first nucleotide sequence encoding the shRNA, ribozyme or microRNA, wherein the shRNA, ribozyme or microRNA is capable of inhibiting UBE3A silencing. paternal. In another aspect, the invention provides a pharmaceutical composition comprising the polynucleotide having the first nucleotide sequence encoding the shRNA, ribozyme or microRNA, wherein the shRNA, ribozyme or microRNA is capable of inhibiting UBE3 silencing. A parent or the viral particle comprising the polynucleotide and a pharmaceutically acceptable carrier. In another aspect, the invention provides a method of treating Angelman syndrome comprising administering to a patient in need thereof, a therapeutically effective amount of the viral particle comprising the polynucleotide having the first nucleotide sequence encoding the shRNA, the ribozyme or microRNA, wherein the shRNA, ribozyme or microRNA is capable of inhibiting the silencing of paternal UBE3A or a pharmaceutical composition thereof. In another aspect, the invention provides a method of activating or increasing the expression of the paternal UBE3A gene comprising administering to a patient in need thereof, a therapeutically effective amount of the viral particle comprising the polynucleotide having the first nucleotide sequence. encoding the shRNA, ribozyme or microRNA, wherein the shRNA, ribozyme or microRNA is capable of inhibiting the silencing of paternal UBE3A or a pharmaceutical composition of the encenn / ίζηζ / Ε / γίΛΐ itself. In another aspect, the invention provides a method for inhibiting the silencing of the paternal UBE3A gene by means of the antisense RNA transcript encoded by SEQ ID NO: 1, which comprises administering to a patient in need thereof, a therapeutically effective amount of the particle virus comprising the polynucleotide having the first nucleotide sequence encoding the short hairpin RNA (shRNA), ribozyme or microRNA, wherein the shRNA, ribozyme or microRNA is capable of inhibiting the silencing of paternal UBE3A or a pharmaceutical composition thereof. In another aspect, the invention provides a shRNA, ribozyme or microRNA encoded by the polynucleotide described herein and capable of inhibiting the silencing of paternal UBE3A. Brief description of the figures Figure 1 shows the chromosomal mutations in Angelman syndrome. Figure 2 shows a diagram of the paternal UBE3 A gene. Figure 3A shows how hammerhead ribozymes cut UBE3 A-ATS in vitro. Hammerhead ribozyme and UBE3A-ATS DNA were transcribed in vitro using PCR. The resulting ribozyme and UBE3A-ATS RNA were incubated in vitro (without cells and without vectors) and the section visualized on an agarose gel. Figure 3B shows how hammerhead ribozymes cleave UBE3 A-ATS in SA human iPSC-derived neurons. Figure 4 shows how shRNAs downregulate UBE3 A-ATS expression and activate paternal UBE3 A. RT-qPCR was performed on lentivirus-transduced SA iPSC-derived neurons to express UBE3 A-ATS-targeted shRNAs. One of the three shRNAs downregulated the expression of both UBE3 A-ATS and activated paternal UBE3A. Figure 5 shows SA neurons transduced with AAV9 particles carrying 551 shRNA 2. The AAV vector also carries EGFR, which allows green fluorescence upon transduction of a neuron. These neurons were transduced with 1 X f O5 viral genomes per cell. Figure 6 shows the plasmid map for pAV-U6-GFP, AAV vector 551 was used to clone shRNA2. Detailed description of the invention UBE3A UBE3 A is a gene encoding E3 ubiquitin ligase. The genomic coordinates for UBE3A are hgl9 chrl5:25,582,381 -25,684,f 75 on the negative strand. There are three normal isoforms of UBE3A: Isoform f (accession number X98032); isoform 2 (accession number X9803f) and isoform 3 (accession number X98033). In neurons, UBE3A is expressed exclusively from the maternal allele. The paternal UBE3A allele is epigenetically silenced by a long non-coding RNA, called the UBE3A antisense transcript (UBE3A-ATS) encoded by SEQ ID NO: 1. The genomic coordinates for UBE3A-ATS are hgl9 chrl5:25,223,730-25,664,609 on strand positive. The following genomic coordinates are rncrnn / Lznz / E / YiAi of particular interest: hgl9 chrl5:25,522,751-25,591,391 on the positive strand. The compositions and methods of the invention target the UBE3A antisense transcript (UBE3A-ATS) to activate the paternal UBE3A allele. Effective inhibition of UBE3 A-ATS by short hairpin RNAs (shRNAs), ribozymes, or microRNAs may result in decreased expression levels of UBE3A-ATS and a concomitant increase in expression levels of the paternal UBE3A allele. In various aspects of the invention, the compositions and methods herein relate to the treatment or prevention of AS. In certain aspects of any of the foregoing modalities that relate to a method of treating a patient or human in need, the patient or human in need has SA or is at risk of developing SA. As used herein, the term "patient in need" includes any mammal in need of these methods of treatment or prophylaxis, including particularly humans. The subject may be male or female. In certain respects, the AS patient in need treated in accordance with the methods provided herein may show improvement in anxiety, learning, balance, motor function and / or seizures or the method may return the resting membrane potential of neurons to approximately -70 mV, ameliorate action potential development delay, increase spontaneous synaptic activity, and may ameliorate additional rheobase-related alterations in neuronal phenotype, synaptic characteristics action potential (eg, shape), membrane current, synaptic potentials, ion channel conductance, etc. shRNA, ribozyme, microRNA and coding sequences According to one aspect of the invention, a polynucleotide comprises a first nucleotide sequence encoding a short hairpin RNA (shRNA), ribozyme or microRNA that results in downregulation of the sequence of UBE3A-ATS, SEQ ID NO: 1. For example, a portion of the shRNA, ribozyme or microRNA may be complementary to the RNA sequence encoded by SEQ ID NO: 1 or a sequence contained therein. ShRNA, ribozyme, and microRNA are RNA polynucleotides encoded by a first nucleotide sequence. The polynucleotide comprising the first nucleotide sequence may be a suitable DNA polynucleotide to be cloned into an appropriate vector (eg a plasmid) for cultivation and subsequent production of viral particles. In turn, the viral particles may contain the DNA polynucleotide with the coding nucleotide sequence in a form suitable for infection. Accordingly, the first nucleotide sequence can be a DNA sequence cloned into a plasmid for the production of viral particles or encapsulated in a viral particle. Since retroviruses carry nucleotide coding sequences in the form of RNA polynucleotides, retroviral particles (eg lentiviruses) contain an RNA polynucleotide comprising the first nucleotide sequence as a corresponding RNA sequence. The first nucleotide sequence may encode the shRNA. For example, the first nucleotide sequence can be SEQ ID NO: 2. The first nucleotide sequence can also be a modified SEQ ID NO: 2 that has the bold nucleotides of SEQ ID NO: 2 replaced by encenn / ίζηζ / Ε / γίΛΐ any of SEQ ID NO: 9-508 and the italicized nucleotides in SEQ ID NO: 2 replaced by nucleotides complementary to those of SEQ ID NO: 9-508. The first nucleotide sequence may encode the ribozyme. For example, the first nucleotide sequence may be SEQ ID NO: 3. The first nucleotide sequence may be SEQ ID NO: 4. The first nucleotide sequence may encode the microRNA. For example, the first nucleotide sequence can be SEQ ID NO: 8. The first nucleotide sequence can also be a modified SEQ ID NO: 8 having the nucleotides in bold in SEQ ID NO: 8 replaced by any of the following. SEQ ID NO: 9-508 and the italicized nucleotides in SEQ ID NO: 8 replaced by nucleotides complementary to those of SEQ ID NO: 9-508. Nucleotides in italics and nucleotides complementary to those in SEQ ID NO: 9-508 may be less than 100% complementary. As used herein, "target" means an RNA polynucleotide capable of hybridization to a nucleotide sequence by hydrogen bonding, such as a nucleotide sequence transcribed from a nucleotide sequence within the largest genomic sequence of UBE3A-ATS. Hybridization of a working RNA polynucleotide to a nucleotide sequence transcribed from a nucleotide sequence with the larger genomic sequence of UBE3A-ATS may result in reduced expression levels of UBE3A-ATS in the presence of the RNA polynucleotide. functional compared to the expression levels of UBE3AATS in the absence of the functional RNA polynucleotide. Preferably, the functional RNA polynucleotide comprises the nucleotide sequence of the shRNA, ribozyme or microRNA that is complementary to the RNA sequence encoded within the larger UBE3A-ATS genomic sequence. For example, shRNA or microRNA contain nucleotide sequences complementary to the RNA sequences encoded by SEQ ID NO: 5 and SEQ ID NO: 9-508 and ribozymes contain nucleotide sequences complementary to the RNA sequences encoded by SEQ ID NO: 6 or SEQ ID NO: 7. Working RNA polynucleotide thus refers to a working portion of the shRNA, ribozyme or microRNA after assimilation of the shRNA, ribozyme or microRNA in a target organism and its processing in a functional state. "Reducing expression" refers to the reduction or blocking of the expression or activity of UBE3AATS and does not necessarily indicate a complete elimination of expression or activity. Mechanisms for reducing target expression include hybridization of a working RNA polynucleotide with a target sequence(s) transcribed from a sequence(s) within the larger UBE3A-ATS genomic sequence (SEQ ID NO: 1), wherein the result or effect of hybridization is degradation of the target or occupancy of the target with concomitant shutdown of cellular machinery involving, for example, transcription or splicing. Without wishing to be bound by any particular theory, the shRNA, ribozyme, and microRNA of the invention can inhibit paternal UBE3A silencing by: (1) cleavage of the RNA transcript encoded by SEQ ID NO: 1; (2) reduction of steady-state levels (ie, baseline levels in homeostasis) of the RNA transcript encoded by SEQ ID NO: 1 and (3) termination of transcription encenn / Lznz / E / YiAi of SEQ ID NO: 1. For example, cleavage and reduction of steady-state levels of the RNA transcript encoded by SEQ ID NO: 1 may occur through a mechanism involving an RNA-induced silencing complex ( RISC). Both shRNA and microRNA can use RISC. Once the vector carrying genomic material for the shRNA or microRNA is integrated into the host genome, the shRNA or microRNA genomic material is transcribed in the host into pri-microRNA. The pri-microRNA is processed by a ribonuclease, such as Drosha, into pre-RNA or pre-microRNA, respectively, and exported from the nucleus. The pre-shRNA or pre-microRNA is processed by an endoribonuclease, such as Dicer, to form small interfering RNA (siRNA) or microRNA, respectively. For siRNA, the siRNA is loaded into the RISC, where the sense strand is degraded and the antisense strand acts as a guide directing the RISC to the complementary sequence on the mRNA. For microRNA, a single strand of the microRNA is loaded into the RISC, which acts as a guide directing the RISC to the complementary sequence on the mRNA. RISC cuts the mRNA when the sequence is perfectly complementary and represses translation of the mRNA when the sequence is imperfectly complementary. In another example, cleavage and reduction of steady state levels of the RNA transcript encoded by SEQ ID NO: 1 may occur through a mechanism involving a ribozyme. Once the vector carrying the genomic material for the ribozyme is integrated into the host genome, the RNA is transcribed in the host. The RNA forms a secondary structure that has a catalytic domain and a region complementary to the target mRNA. When the ribozyme binds to the target mRNA, the catalytic domain cuts the target mRNA. Transcription of SEQ ID NO: 1 can be disrupted via the torpedo mechanism where 5'-3' and 3'-5' exonucleases (eg, XRN2) attach to the cleaved, uncapped end. of the target RNA being transcribed. The 5'-3' exonuclease traps the polymerase and separates it from the DNA. Therefore, the shRNA, ribozyme, and microRNA encoded by the first nucleic acid sequence can increase expression of paternal UBE3A by lowering equilibrium UBE3A-ATS RNA levels. As used herein, the term "nucleic acid" refers to molecules composed of monomeric nucleotides. Examples of nucleic acids include ribonucleic acids (RNA), deoxyribonucleic acids (DNA), single-stranded nucleic acids, double-stranded nucleic acids, small interfering ribonucleic acids (siRNAs), short hairpin RNAs (shRNAs), and microRNAs (miRNAs). "Nucleotide" means a nucleoside that has a phosphate group covalently attached to the sugar portion of the nucleoside. Oligonucleotide or polynucleotide refers to a polymer of linked nucleotides, each of which can be modified or unmodified, independently of one another. As used herein, a short hairpin RNA (shRNA) includes a conventional stem-loop shRNA, which forms a precursor microRNA (pre-miRNA). ShRNA also includes microRNA-embedded shRNAs (miRNA-based shRNAs), where the leader strand and passenger strand of the miRNA duplex are incorporated into an existing (or natural) miRNA or a modified or synthetic (engineered) miRNA. When transcribed, a conventional shRNA (ie, not a miR-451 mimic shRNA) forms a primary miRNA (pri-miRNA) or a structure very similar to a natural pri-miRNA. The pri-miRNA is further processed by Drosha and its cofactors into the pre-shRNA. Therefore, the term "shRNA" includes pri-miRNA (mir-shRNA) molecules and pre-shRNA molecules. A "stem-loop structure" refers to a nucleic acid having a secondary structure that includes a region of nucleotides known or predicted to form a double strand or duplex (stem portion) that is joined on one side by a region of predominantly single-stranded nucleotides (loop portion). It is known in the art that the loop portion is at least 4 nucleotides in length, preferably 6 nucleotides (eg, the underlined sequence in SEQ ID NO: 2). The terms "hairpin" and "folded" structures are also used herein to refer to stem-loop structures. Such structures are well known in the art and the term is used consistently with its art-known meaning. As is known in the art, the secondary structure does not require exact base pairing. Accordingly, the stem may include one or more mismatched bases or knobs. Alternatively, the base pairing may be exact, ie not include any mismatches. In some embodiments, shRNAs useful in this invention include, without limitation, modified shRNAs, including shRNAs with improved in vivo stability. Modified shRNAs include molecules that contain nucleotide analogs, including those molecules that have additions, deletions, and / or substitutions in the core, sugar, or backbone base; and molecules that are crosslinked or otherwise chemically modified. The modified nucleotides may be within portions of the shRNA molecule or throughout the entire molecule. For example, the shRNA molecule may be modified or contain modified nucleic acids in regions at its 5' and 3' end or both and / or within the leader strand, the passenger strand or both, and / or within the nucleotides that protrude from the 5' end, the 3' end, or both. (See Crooke, US Patent Nos. 6,107,094 and 5,898,031; Elmen et al., US Publication Nos. 2008 / 0249039 and 2007 / 0191294; Manoharan et al., US Publication Nos. 2008 / 0213891; MacLachlan et al., US Publication No. 2007 / 0135372 and Frog, US Publication No. 2005 / 0020521; all of which are incorporated herein by reference). In the present invention, shRNAs comprise a nucleotide sequence complementary to an RNA nucleotide sequence transcribed from within the complete genomic sequence of UBE3A-ATS (SEQ ID NO: 1) and inhibits the silencing of paternal UBE3A by UBE3A-ATS . In additional embodiments, the shRNAs comprise a nucleotide sequence complementary to the RNA sequences encoded by SEQ ID NO: 9-508. In a more particular embodiment, a shRNA comprises a nucleotide sequence complementary to an RNA sequence encoded by SEQ ID NO: 5. In a particular embodiment, the shRNA is encoded by the nucleotide sequence of SEQ ID NO: 2. In embodiments of the present invention, the nucleotide sequence comprised in the shRNA complementary to the nucleotide sequence of the UBE3A-ATS gene transcribed RNA is 17-21 nucleotides in length. The complementary nucleotides may be contiguous or may be interspersed with non-complementary nucleotides. In some embodiments, the complementary nucleotide sequence is 21 nucleotides in length, as indicated by the bold sequence in the encenn / ιζπζ / ε / υιλι SEQ ID NO: 2. The shRNA may comprise a nucleotide sequence where 17, 18, 19, 20 or 21 nucleotides are complementary to the nucleotides in SEQ ID NO: 5 or 9-508. The 17, 18, 19, 20, or 21 complementary nucleotides may be contiguous or may be interspersed with non-complementary nucleotides. The total length of the shRNA, including the loop, can be 40-50 nucleotides, preferably 44-48 nucleotides, more preferably 48 nucleotides. As used herein, the term "ribozyme" refers to an RNA molecule that acts as an enzyme or a molecule composed of a protein that comprises the RNA molecule and is also called an RNA enzyme or catalytic RNA. Ribozymes have been found to catalyze chemical reactions with RNA molecules with a defined tertiary structure and have catalytic or autocatalytic properties. Some ribozymes cleave themselves or other RNA molecules to inhibit their activity, and other ribozymes catalyze the aminotransferase activity of ribosomes. Such ribozymes may include hammerhead ribozymes, VS ribozymes, hairpin ribozymes, etc. In the present invention, ribozymes comprise a nucleotide sequence complementary to an RNA nucleotide sequence transcribed from the complete genomic sequence of UBE3A-ATS (SEQ ID NO: 1) and inhibit the silencing of paternal UBE3A by UBE3A-ATS. In additional embodiments, the ribozymes comprise a nucleotide sequence complementary to the RNA sequences encoded by SEQ ID NO: 6 and / or SEQ ID NO: 7. In additional embodiments, the ribozyme is encoded by the nucleotide sequence of the SEQ ID NO: 3 or 4. In SEQ ID NO: 3 and 4, the sequences in bold are complementary to SEQ ID NO: 6 or 7 and the underlined sequences signify the catalytic region of the ribozyme. As used herein, the terms microRNA, miRNA, and m¡R are used synonymously to refer to non-coding RNAs approximately 17-21 nucleotides (nt) in length derived from endogenous genes. MicroRNAs are processed from longer (about 75 nt) hairpin-shaped precursors, called pre-mRNA. MicroRNAs assemble into ribonucleoprotein complexes called miRNPs and recognize their targets by antisense complementarity. If the microRNAs match 100% to their target, ie complementarity is complete, the target mRNA is cleaved and the miRNA acts as an siRNA. If the match is incomplete, ie the complementarity is partial, the translation of the target mRNA is blocked. In embodiments of the present invention, the nucleotide sequence comprised in the microRNA and complementary to the nucleotide sequence of the RNA transcript of the UBE3A-ATS gene is 17-21 nucleotides in length. The complementary nucleotides may be contiguous or may be interspersed with non-complementary nucleotides. In some embodiments, the complementary nucleotide sequence is 21 nucleotides in length, as indicated by the bold sequence in SEQ ID NO: 8. The microRNA may comprise a nucleotide sequence where 17, 18, 19, 20, or 21 nucleotides are complementary to the nucleotides in SEQ ID NO: 5 or 9-508. The 17,18,19,20 or 21 complementary nucleotides may be contiguous or may be interspersed with non-complementary nucleotides. The total length of the precursor microRNA, including the loop, can be 50-1000 nucleotides, preferably 59-67 nucleotides, more preferably 67 nucleotides. pncrnn / Lznz / E / YiAi In the present invention, the microRNAs are designed to target one or more nucleotide sequences transcribed from one or more nucleotide sequences within the complete genomic sequence of UBE3A-ATS (SEQ ID NO: 1) and inhibits the silencing of the UBE3A-ATS. UBE3A paternal by UBE3A-ATS. In additional embodiments, the microRNAs target a transcribed sequence of SEQ ID NO: 9-508. In a more particular embodiment, the target microRNA targets a transcribed sequence of SEQ ID NO: 5. In additional embodiments, the microRNA is encoded by the nucleotide sequence of SEQ ID NO: 8, where the sequence in bold is complementary to SEQ ID NO: 5 or 9-508. Methods for determining whether a sequence is specifically hybridizable to a target nucleic acid are well known in the art. In certain embodiments, the shRNA, ribozyme, or microRNA polynucleotides provided herein comprise a nucleic acid sequence specifically hybridizable to a UBE3A-ATS transcribed RNA sequence, SEQ ID NO: 1. The shRNA or microRNA may comprise an RNA polynucleotide containing a region of 17-21 linked nucleotides complementary to the target RNA sequence, wherein the region of the RNA polynucleotide is at least 85% complementary over its entire length to a region of equal length of a nucleic acid sequence of the UBE3A-ATS RNA. In certain aspects, the RNA polynucleotide region is at least 90%, 95%, or 100% complementary over its entire length to an equal length region of a UBE3A-ATS RNA nucleic acid sequence. The shRNA or microRNA may comprise a nucleotide sequence that is at least 85% complementary and of the same length as, an RNA sequence encoded by SEQ ID NO: 5 or any of SEQ ID NO: 9-508. The shRNA or microRNA may comprise a nucleotide sequence that is at least 90% complementary and of the same length as, an RNA sequence encoded by SEQ ID NO: 5 or any of SEQ ID NO: 9-508. The shRNA or microRNA may comprise a nucleotide at least 95% complementary to, and equal in length to, an RNA sequence encoded by SEQ ID NO: 5 or any of SEQ ID NO: 9-508. The shRNA or microRNA may comprise a 100% complementary nucleotide sequence of equal length as, an RNA sequence encoded by SEQ ID NO: 5 or any of SEQ ID NO: 9-508. The ribozyme may comprise an RNA polynucleotide containing two linked nucleotide regions complementary to the target RNA sequence, separated by a catalytic region, wherein the overall non-catalytic region of the RNA polynucleotide is at least 85% complementary over its entire length. to an equal length region of a UBE3A-ATS RNA nucleotide sequence. In certain aspects, the overall non-catalytic region of the RNA polynucleotide is at least 90%, at least 95%, or 100% complementary over its entire length to a region of equal length from a UBE3A-ATS RNA nucleotide sequence. In embodiments of the present invention, the nucleotide sequence comprised in the ribozyme and complementary to the nucleotide sequence of the RNA transcribed from the UBE3AATS gene is 17-21 nucleotides in length. Complementary nucleotides can be interspersed with non-complementary nucleotides. In some embodiments, the complementary nucleotide sequence is 21 nucleotides in length, as indicated by the boldface sequence of SEQ ID NO: 3-4. The ribozyme may comprise a nucleotide sequence where 17, 18, 19, 20 or encenn / Lznz / E / YiAi nucleotides are complementary to the nucleotides in SEQ ID NO: 6-7. The 17, 18, 19, 20 or 21 complementary nucleotides may be interspersed with non-complementary nucleotides. The overall length of the shRNA, including the catalytic loop, may be 50-150 nucleotides in length, preferably 57-65 nucleotides, more preferably 59 nucleotides. The ribozyme may comprise a nucleotide sequence that is at least 85% complementary to, and equal in length to, an RNA sequence encoded by SEQ ID NO: 6 or 7. The ribozyme may comprise a nucleotide sequence that is at least 90% complementary to , and equal in length to, an RNA sequence encoded by SEQ ID NO: 6 or 7. The ribozyme may comprise a nucleotide sequence that is at least 95% complementary to, and equal in length to, an RNA sequence encoded by SEQ ID NO: SEQ ID NO: 6 or 7. The ribozyme may comprise a nucleotide sequence that is 100% complementary to, and equal in length to, an RNA sequence encoded by SEQ ID NO: 6 or 7. In certain aspects, the shRNA, ribozyme, or microRNA is a single-stranded RNA polynucleotide. In various aspects, the RNA polynucleotide is a modified RNA polynucleotide. A percentage complementarity is used herein in the conventional sense to refer to the base pairing between adenine and thymine, adenine and uracil (RNA), and guanine and cytosine. Non-complementary core bases can be tolerated between a shRNA, ribozyme, or microRNA and a UBE3A-ATS nucleotide sequence, as long as the shRNA, ribozyme, or microRNA remains capable of specifically hybridizing to a UBE3A nucleotide sequence. -ATS. In addition, a shRNA, ribozyme, or microRNA can hybridize to one or more segments of a UBE3A-ATS nucleotide sequence such that intervening or adjacent segments are not involved in the hybridization event (for example, a structure loop, mismatch, or hairpin structure). In certain embodiments, the shRNA, ribozyme, or microRNA provided herein, or a specified portion thereof, is, or is at least, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 917th, 92 7th, 93 7th, 94 7th, 95 7th, 96 7th, 97 7th, 98 7th, 99 7th or 100 7th complementary to a UBE3A-ATS RNA nucleotide sequence, a region of UBE3A-ATS, a segment of UBE3A-ATS, or a specified portion thereof. The percent complementarity of a shRNA, ribozyme, or microRNA with a UBE3A-ATS nucleotide sequence can be determined by routine methods. For example, a shRNA, ribozyme, or microRNA in which 18 of 20 core bases of the shRNA, ribozyme, or microRNA are complementary to a region of UBE3A-ATS and would therefore specifically hybridize would represent 90 percent complementarity. . In this example, the remaining non-complementary core bases may be clustered or interspersed with complementary core bases and need not be contiguous with each other or with complementary core bases. As such, a shRNA, ribozyme, or microRNA that is 18 core bases long and four non-complementary core bases that are flanked by two regions of complete complementarity with the target nucleotide sequence would have 77.8 7o overall complementarity with the target nucleotide sequence. target nucleotide sequence and would therefore fall within the scope of the present invention. The encenn / Lznz / E / YiAi percentage complementarity of a shRNA, ribozyme or microRNA with a region of a UBE3A-ATS nucleotide sequence can be routinely determined using BLAST (Basic Local Alignment Search Tool) programs and PowerBLAST programs known in the art (Altschul et al., J. Mol. Biol., 1990, 215, 403-410; Zhang and Madden, Genome Res., 1997, 7, 649-656). Percent homology, sequence identity or complementarity can be determined, for example, with the Gap program (Wisconsin Sequence Analysis Package, Version 8 for Unix, Genetics Computer Group, University Research Park, Madison Wis.), using the default configuration, which uses the Smith and Waterman algorithm (Adv. Appl. Math., 1981, 2, 482-489). In certain embodiments, the shRNA, ribozyme, or microRNA provided herein, or specific portions thereof, are fully complementary (i.e., 100% complementary) to a UBE3A-ATS nucleotide sequence, or to a specific portion of the UBE3A-ATS product. transcript of SEQ ID NO: 1 of the same. For example, a shRNA, ribozyme, or microRNA may be fully complementary to a UBE3A-ATS nucleotide sequence or a region or segment thereof. As used herein, "fully complementary" means each core base of a shRNA, ribozyme, or microRNA is capable of precisely matching the corresponding RNA core bases transcribed from a UBE3AATS nucleotide sequence. An effective concentration or dose of the shRNA, ribozyme, or microRNA can inhibit the silencing of paternal UBE3A by UBE3A-ATS by at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 100%. An effective concentration or dose of the shRNA, ribozyme, or microRNA can disrupt UBE3A-ATS transcription by at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70 %, at least 80%, at least 90%, or at least 100%. An effective concentration or dose of the shRNA, ribozyme, or microRNA can reduce steady-state levels of UBE3A-ATS by at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, by least 70%, at least 80%, at least 90%, or at least 100%. An effective concentration or dose of the shRNA, ribozyme, or microRNA can cleave UBE3AATS and reduce by at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90% or at least 100%. An effective concentration or dose of the shRNA, ribozyme or microRNA can reduce the expression of UBE3A-ATS by at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 100% and induce expression of the paternal UBE3A in at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70 %, at least 80%, at least 90%, or at least 100%. As used herein, the terms "UBE3 A-ATS" and "Ube3 A-ATS" may be used interchangeably without capitalization in their spelling to refer to any particular species or ortholog. UBE3 A and Ube3 A can be used interchangeably without capitalization in their spelling to refer to a particular species or ortholog. Additionally, UBE3A, UBE3A, Ube3A" and Ube3A can be used interchangeably without italics in reference to the nucleic acid or protein unless specifically indicated otherwise. viral vector A"vector" is a replicon, such as a plasmid, phage or cosmid, into which another segment of DNA can be inserted to cause replication of the inserted segment. Generally, a vector is capable of replication when associated with the appropriate control elements. Vector backbones include, for example, those commonly used in the art, such as plasmids containing a viral genome, viruses, or artificial chromosomes. The term "vector" includes cloning and expression vectors, as well as viral vectors and integration vectors. As will be apparent to one skilled in the art, the term viral vector is broadly used to refer to a nucleic acid molecule (eg, a transfer plasmid) that includes viral nucleic acid elements that normally facilitate transfer of the viral nucleic acid molecule. nucleic acid to a cell or a viral particle that mediates the transfer of the nucleic acid sequence and / or the integration of the nucleic acid sequence into the genome of a cell. Viral vectors contain structural and / or functional genetic elements that are potentially derived from a virus. The viral vector is desirably non-toxic, non-immunogenic, easy to produce, and efficient in protecting and delivering DNA or RNA to target cells. According to the compositions and methods of the invention, a viral vector may contain the DNA encoding the shRNA, ribozyme and / or microRNA of the invention. In particular embodiments, the viral vector is a lentiviral vector or an adeno-associated viral (AAV) vector. As used herein, the term lentivirus refers to a group (or genus) of complex retroviruses. Illustrative lentiviruses include, but are not limited to: HIV (human immunodeficiency virus; including HIV type 1 and HIV type 2); Visna-Maedi virus (VMV); caprine arthritis-encephalitis virus (CAEV); Equine Infectious Anemia Virus (EIAV); feline immunodeficiency virus (FIV); bovine immunodeficiency virus (BIV) and simian immunodeficiency virus (SIV). The lentivirus will transduce dividing cells and postmitotic cells. The term "lentiviral vector" refers to a viral vector (eg, viral plasmid) that contains structural and functional genetic elements, or portions thereof, including long terminal repeats (LTRs) that are derived from mainly from a lentivirus. A lentiviral vector is a hybrid vector (eg, in the form of a transfer plasmid) comprising retroviral, eg, lentiviral, sequences for reverse transcription, replication, integration and / or packaging of nucleic acid sequences (eg, sequences coding). The term "retroviral vector" refers to a viral vector (eg, transfer plasmid) that contains structural and functional genetic elements, or portions thereof, that are primarily derived from a retrovirus. Adenoviral vectors are designed to be administered directly to a living subject. Unlike retroviral vectors, most of the genomes of adenoviral vectors do not integrate into the host cell chromosome. In turn, genes introduced into cells using adenoviral vectors are maintained in the nucleus as an extrachromosomal element (episome) that persists for a long period of time. Adenoviral vectors will transduce dividing and non-dividing cells in many different tissues in vivo, including airway epithelial cells, endothelial cells, hepatocytes, and various tumors (Trapnell, 1993; Chuah et al., 2003). The term adeno-associated virus (AAV) refers to a small ccDNA virus that infects humans and some other primate species, is not known to cause disease, and causes only a very mild immune response. AAV can infect both dividing and non-dividing cells and can incorporate its genome into that of the host cell. These characteristics make AAV a very attractive candidate for creating viral vectors for gene therapy, although the cloning ability of the vector is relatively limited. In a preferred embodiment of the invention, the vector used is derived from adeno-associated virus (ie AAV vector). More than 30 naturally occurring AAV serotypes are available. Many natural variants exist in the AAV capsid, allowing the identification and use of an AAV with properties specifically suited for specific types of target cells. AAV viruses can be genetically modified by conventional molecular biology techniques, making it possible to optimize these particles for cell-specific delivery of shRNA, ribozyme or microRNA DNA sequences to minimize immunogenicity, to adjust stability and life of the particles, for efficient degradation, for precise delivery to the nucleus, etc. An "expression vector" is a vector that includes a regulatory region. Various vectors and expression systems are commercially available from corporations such as Novagen (Madison, Wis.), Clontech (Palo Alto, Calif), Stratagene (La Jolla, Calif.), and Invitrogen / Life Technologies (Carlsbad, Calif). An expression vector can be a viral expression vector derived from a particular virus. The vectors provided herein may also include, for example, origins of replication, framework binding regions (SARs), and / or markers. A marker gene can confer a selectable phenotype to a host cell. For example, a marker can confer biocide resistance, such as resistance to an antibiotic (eg, kanamycin, G418, bleomycin, or hygromycin). An expression vector can include a marker sequence designed to facilitate manipulation or detection (eg, purification or localization) of the expressed polypeptide. Marker sequences, such as green fluorescent protein (GFP), glutathione S-transferase (GST), polyhistidine, c-myc, hemagglutinin, or Flag™ marker sequences (Kodak, New Haven, Connecticut) are typically expressed as a fusion with the encoded polypeptide. Such markers can be inserted anywhere within the polypeptide, including at the carboxyl or amino terminus. Additional expression vectors can also include, for example, segments of chromosomal, non-chromosomal, or synthetic DNA sequences. Suitable vectors include derivatives of pure pLKO.1, SV40, and plasmids such as RP4; Phage DNA, eg, the many derivatives of phage 1, eg, NM989, and other phage DNA, eg, M13 and encenn / ιζπζ / ε / υιλι filamentous single-stranded phage DNA, vectors useful in eukaryotic cells, such as vectors useful in insect or mammalian cells, vectors derived from combinations of plasmids and phage DNA, such as plasmids that have been modified to use phage DNA or other expression control sequences. The vector can also include a regulatory region. The term "regulatory region" refers to nucleotide sequences that influence the initiation and rate of transcription or translation and the stability and / or mobility of a transcription or translation product. Regulatory regions include, without limitation, promoter sequences, enhancer sequences, response elements, protein recognition sites, inducible elements, protein binding sequences, 5' and 3' untranslated regions (UTRs). , transcription start sites, termination sequences, polyadenylation sequences, nuclear localization signals, and introns. As used herein, the term "operably linked" refers to the positioning of a regulatory region and a transcription sequence in a nucleic acid to influence transcription or translation of said sequence. For example, for a coding sequence to be under the control of a promoter, the translation start site of the polypeptide translation reading frame is typically between one and about fifty nucleotides downstream of the promoter. However, a promoter can be located up to about 5,000 nucleotides upstream of the translation start site or about 2,000 nucleotides upstream of the transcription start site. A promoter typically comprises at least one major (basal) promoter. A promoter can also include at least one control element, such as an enhancer sequence, upstream element, or upstream activation region (UAR). The selection of promoters to include depends on several factors, including, but not limited to, efficiency, selectivity, inducibility, desired expression level, and cell or tissue preferential expression. It is a matter of routine for one skilled in the art to modulate the expression of a coding sequence by selecting and properly positioning promoters and other regulatory regions relative to the coding sequence. Vectors may also comprise other components or functionalities that further modulate gene delivery and / or gene expression, or otherwise provide beneficial properties to target cells. As described and illustrated in more detail below, such other components include, for example, components that influence cell binding or targeting (including components that mediate cell type or tissue-specific binding); components that influence the uptake of the vector nucleic acid by the cell; components that influence the localization of the polynucleotide within the cell after uptake (such as agents that mediate nuclear localization); and components that influence expression of the polypeptide. Such components could also include markers, such as detectable and / or selectable markers that can be used to detect or select for cells that have taken up and are expressing the vector-delivered nucleic acid. Such components may be provided as a natural feature of the vector (such as the use of certain viral vectors which have components or functionalities that mediate binding and uptake), or vectors that may be modified to provide such encenn / Lznz / E / YiAi functionalities. Other vectors include those described by Chen et al; BioTechniques, 34: 167-171 (2003). A wide variety of such vectors are known in the art and are generally available. A recombinant viral vector refers to a viral vector comprising one or more heterologous gene sequences or products. Because many viral vectors have size limitations associated with packaging, heterologous gene sequences or products are typically introduced by replacing one or more portions of the viral genome. Such viruses can become replication-defective, requiring the deleted function(s) to be provided in trans during viral replication and encapsidation (using, for example, a helper virus or a packaging cell line carrying the gene products necessary for replication and / or packaging). In some embodiments, the viral vector used in the invention will be used at a concentration of at least 105 viral genomes per cell. Selection of the right promoters can be easily accomplished. An example of a suitable promoter is an RNA polymerase II or III promoter, such as the U6 promoter. Other suitable promoters that can be used for gene expression include, inter alia, the 763 base pair promoter of cytomegalovlrus (CMV), Rous sarcoma virus (RSV) (Davis, et al., Hum Gene Ther4:151 (1993)), SV40 early promoter region, herpes thymidine kinase promoter, metallothionein (MMT) gene regulatory sequences, PGK (phosphoglycerol kinase) promoter, alkaline phosphatase; and the transcriptional control regions of the animals, which show tissue specificity and have been used in transgenic animals: the myelin basic protein gene control region, which is active in brain oligodendrocyte cells, and the control region of the gonadotropic-releasing hormone gene, which is active in the hypothalamus. Certain proteins can be expressed using their original promoter. Other elements that can enhance expression may also be included, such as an enhancer or a system that results in high levels of expression, such as a tat gene or a tar element. This cassette can then be inserted into a vector, eg a plasmid vector such as pLK 0.1, pUC19, pUC118, pBR322 or other known plasmid vectors. See, Sambrook, et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory press, (1989). The plasmid vector may also include a selectable marker, such as the β gene for ampicillin resistance, as long as the marker polypeptide does not adversely affect the metabolism of the treated organism. The cassette can also be linked to a nucleic acid binding moiety in a synthetic delivery system, such as the system disclosed in WO 95 / 22618. The coding sequences for the shRNA, ribozymes, and microRNA can be cloned into viral vectors using any suitable genetic engineering technique well known in the art, including, without limitation, the standard techniques of PCR, polynucleotide synthesis, endonuclease digestion. restriction, ligation, transformation, plasmid purification, and DNA sequencing, as described in Sambrook et al. (Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, N.Y. (1989)), Coffin et al. (Retroviruses. Cold Spring Harbor Laboratory Press, N.Y. encenn / Lznz / E / YiAi (1997)) and RNAViruses: A Practical Approach (Alan J. Cann, Ed., Oxford University Press, (2000)). In a preferred embodiment, the shRNA, ribozyme, and microRNA DNA sequences contain flanking sequences at the 5' and 3' ends that are complementary to sequences in the plasmid and / or vector that is cut by a restriction endonuclease. As is well known in the art, flanking sequences are dependent on the restriction endonucleases used during restriction digest of the plasmid and / or vector. Accordingly, one skilled in the art can select the flanking sequences at the 5' and 3' ends of the shRNA, ribozyme and microRNA sequences accordingly. In another preferred embodiment, the target sites can be cloned into vectors by nucleic acid exchange and fusion technologies currently known in the art, including Gateway, POR Fusion, Cre-lox P, and Creator. In some embodiments, an expression vector comprises a promoter and a polynucleotide comprising a first nucleotide sequence encoding a short hairpin RNA (shRNA), ribozyme, or microRNA of the invention. Preferably, the promoter and the polynucleotide comprising the first nucleotide sequence are operably linked. Preferably, the promoter is a U6 promoter. The first nucleotide sequence included in the expression vector may be SEQ ID NO: 2. The first nucleotide sequence included in the expression vector may be SEQ ID NO: 3. The first nucleotide sequence included in the expression vector expression may be SEQ ID NO: 4. The first nucleotide sequence included in the expression vector may be SEQ ID NO: 8. The polynucleotide comprising the first nucleotide sequence in the expression vector is preferably a DNA polynucleotide . The first nucleotide sequence of the expression vector is preferably a DNA nucleotide sequence. The shRNA, ribozyme, or microRNA encoded by the first nucleotide sequence of the expression vector can be as described in any of the variants disclosed herein. As discussed above, recombinant viral vectors are transfected into packaging cells or cell lines, together with the necessary elements for packaging the recombinant viral particles. Recombinant viral particles harvested from the supernatant of transfected cells are used to infect target cells or organisms for expression of shRNA, ribozymes, or microRNA. Transduced cells or organisms are used for transient expression or selected for stable expression. virus particle Viral particles are used to deliver the coding nucleotide sequences to shRNAs, ribozymes, and microRNAs that target UBE3A-ATS RNA. Viral particles can typically include various viral components and sometimes host cell components as well, in addition to nucleic acid(s). The nucleic acid sequences can be packaged into a viral particle capable of delivering the shRNA, ribozyme and / or microRNA nucleic acid sequences into target cells of the patient or human in need thereof. Viral particles can be produced by (a) introducing a viral expression vector into a suitable cell line; (b) culturing the cell line under suitable conditions to allow the production of pncrnn / Lznz / E / YiAi the viral particle; (c) recovering the produced viral particle; and (d) optionally purifying the recovered infectious viral particle. An expression vector containing the nucleotide sequence encoding the shRNA, ribozyme or microRNA of the invention can be introduced into a suitable cell line for propagation or expression using techniques well known and readily available to those skilled in the art. These include, but are not limited to, microinjection of minute amounts of DNA into the nucleus of a cell (Capechi et al., 1980, Cell 22, 479-488), CaPO-mediated transfection, (Chen and Okayama, 1987, Mol. Cell Biol. 7, 2745-2752), DEAE-dextran-mediated transfection, electroporation (Chu et al., 1987, Nucleic Acid Res. 15, 1311-1326), lipofection / liposome fusion (Feigner et al , 1987, Proc. Nati. Acad. Sci. USA 84, 7413-7417), particle bombardment (Yang et al, 1990, Proc. Nati. Acad. Sci. USA 87, 95689572), gene guns, transduction, infection (eg, with an infectious viral particle) and other techniques such as those that can be found in Sambrook, et al. (Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 2001). When the vector of the invention is defective, infectious particles are usually produced in a complementing cell line or by using a helper virus, which delivers non-functional viral genes in trans. For example, cell lines suitable for complementing adenoviral vectors include 293 cells (Graham et al., 1997, J. Gen. Virol. 36, 59-72) as well as PER-C6 cells (Fallaux et al., 1998, Human Gene Ther. 9,1909-1917) commonly used to complement El function. Other cell lines have been designed to complement double-defective adenoviral vectors (Yeh et al, 1996, J. Virol 70, 559-565; Krougliak and Graham, 1995, Human Gene Ther. 6, 1575-1586; Wang et al., 1995, Gene Ther. 2, 775-783; Lusky et al., 1998, J. Virol. 72, 2022-2033; WO94 / 28152 and WO97 / 04119). Infectious viral particles can be recovered from the culture supernatant, but also from cells after lysis, and optionally further purified according to standard techniques (chromatography, ultracentrifugation on a cesium chloride gradient, as described, by example, in publications WO 96 / 27677, WO 98 / 00524, WO 98 / 22588, WO 98 / 26048, WO 00 / 40702, EP 1016700 and WO 00 / 50573). The invention also relates to host cells comprising the nucleic acid molecules, vectors or infectious viral particles of the invention described herein. For the purposes of the invention, the term "host cell" should be understood in a broad sense, without any limitation regarding the particular organization in tissues, organs or isolated cells. Such cells may be of a single cell type or a group of different cell types and include cultured cell lines, primary cells, and proliferating cells. Host cells include prokaryotic cells, lower eukaryotic cells, such as yeast, and other eukaryotic cells, such as insect cells, plant cells, and higher eukaryotic cells, such as vertebrate cells, and most preferably mammalian (for example, human) cells. or non-human). Suitable mammalian cells include, but are not limited to, hematopoietic cells (totipotent, stem cells, leukocytes, lymphocytes, monocytes, macrophages, APCs, encenn / Lznz / E / YiAi dendritic cells, non-human cells, and the like), lung cells , tracheal cells, liver cells, epithelial cells, endothelial cells, muscle cells (eg, skeletal muscle, cardiac muscle, or smooth muscle), or fibroblasts. Preferred host cells include Escherichia coli, Bacillus, Listeria, Saccharomyces, BHK (baby hamster kidney) cells, MDCK (Madin-Darby canine kidney cell line), CRFK cells (Crandell feline kidney cell line), CV-1 cells (African momo kidney cell line), COS cells (for example, COS-7), Chinese hamster ovary (CHO) cells its acronym in English), mouse NIH / 3T3 cells, HeLa cells and Vero cells. Host cells also encompass complementary cells capable of complementing at least one defective function of a replication-defective vector of the invention (eg, an adenoviral vector) such as those cited above. The host cell of the invention can also be encapsulated. Cell encapsulation technology has been previously described (Tresco et al, 1992, ASAJO J. 38,17-23; Aebischer etaL, 1996, Human Gene Ther. 7, 851-860). According to said specific embodiment, transfected or infected eucalyptus host cells are encapsulated with compounds that form a microporous membrane and said encapsulated cells can be further implanted in vivo. Capsules containing the cells of interest can be prepared using hollow microporous membranes (eg, Akzo Nobel Faser AG, Wuppertal, Germany; Deglon et al. 1996, Human Gene Ther. 7, 2135-2146) having a suitable molecular weight. to allow the free passage of proteins and nutrients between the interior and exterior of the capsule, while avoiding contact of the transplanted cells with the host cells. Viral particles suitable for use in the invention include AAV particles and lentiviral particles. AAV particles carry the coding sequences for shRNA, ribozymes, and microRNA in the form of genomic DNA. Lentiviral particles, on the other hand, belong to the class of retroviruses and carry the coding sequences for shRNA, ribozymes, and microRNAs in the form of RNA. Recombinant engineered viral particles, such as AAV particles, artificial AAV particles, self-complementing AAV particles, and lentiviral particles that contain the DNA (or RNA in the case of lentiviral particles) encoding shRNAs, ribozymes, and / or or microRNAs targeting the UBE3A-ATS RNA can be delivered to target cells to inhibit UBE3A silencing by UBE3A-ATS. The use of AAV is a common mode of DNA delivery, as it is relatively non-toxic, provides efficient gene transfer, and can be easily optimized for specific purposes. In one embodiment of the invention, the selected AAV serotype has native neurotropisms. In other embodiments of the invention, the AAV serotype is AAV9 or AAV10. A suitable recombinant AAV is generated by culturing a host cell that contains a nucleotide sequence encoding an AAV serotype capsid protein, or a fragment thereof, as defined herein; a functional rep gene; a minigene composed of at least one AAV inverted terminal repeat (ITR) and coding nucleotide sequence and sufficient helper functions to allow packaging of the minigene into the AAV capsid protein. The components necessary to be grown in the host cell to package an AAV minigene into an AAV capsid can be provided to the encenn / Lznz / E / YiAi host cell in trans. Alternatively, one or more of the required components (eg, the minigene, rep sequences, cap sequences, and / or helper functions) may be provided by a stable host cell that has been engineered to contain one or more of the required components. the required components using methods known to those skilled in the art. Unless otherwise specified, AAV ITRs and other selected AAV components described herein can be readily selected from any AAV serotype, including, without limitation, AAV1, AAV2, AAV3, AAV5, AAV6, AAV7, AAV8, AAV9, AAV10 or other known and unknown AAV serotypes. These ITRs or other AAV components can be readily isolated using techniques available to those skilled in the art from an AAV serotype. Such AAVs can be isolated or obtained from academic, commercial, or public sources (eg, from the American Type Culture Collection, Manassas, Va.). Alternatively, AAV sequences can be obtained through synthetic or other suitable means by reference to published sequences such as those available in the literature or in databases such as GenBank, PubMed, or the like. The minigene, rep sequences, cap sequences, and auxiliary functions necessary to produce the rAAV of the invention can be delivered to the packaging host cell in the form of any genetic element that transfers the sequences it carries. The selected genetic element can be delivered via any suitable method. The methods used for the construction of any embodiment of the present invention are known to those skilled in the art in the manipulation of nucleic acids and include genetic engineering, recombinant engineering and synthetic techniques. See, for example, Sambrook et al, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, Cold Spring Harbor, N.Y. Similarly, methods of generating rAAV virions are well known and the selection of a suitable method is not a limitation on the present invention. See, for example, K. Fisher et al, 1993 J. Viral., 70:520-532 and US Patent No. 5,478,745, among others. These publications are incorporated herein by reference. The selection of these and other common vector elements and regulators are conventional and many such sequences are available. See, for example, Sambrook et al. and references cited therein, eg, pages 3.18-3.26 and 16.17-16.27 and Ausubel et al, Current Protocols in Molecular Biology, John Wiley & Sons, New York, 1989). Of course, not all vectors and expression control sequences will work equally well to express all of the transgenes of this invention. However, one skilled in the art can make a selection between these and other expression control sequences without departing from the scope of this invention. Pharmaceutical compositions and therapeutic treatment Viral particles comprising the desired shRNA, ribozyme and / or microRNA coding sequences can be formulated for administration to a patient or human in need thereof by any suitable means for administration. Said formulation involves the use of a pharmaceutically and / or physiologically acceptable vehicle or carrier, particularly one suitable for administration to the brain, for example, by subcranial or spinal injection. In addition, rncrnn / Lznz / E / YiAi may be administered more than one shRNA, ribozyme and / or microRNA, or any combination thereof, in a combination treatment. In a combination treatment, the different shRNA, ribozyme and / or microRNA can be administered simultaneously, separately, sequentially and in any order. Suitably, the pharmaceutical composition of the invention comprises a carrier and / or diluent suitable for administration by injection to a human or animal body. Such a carrier and / or vehicle is non-toxic at the dose and concentration employed. It is selected from those commonly used to formulate compositions for parental administration in unit or multidose form or for direct infusion by continuous or periodic infusion. It is preferably isotonic, hypotonic, or weakly hypertonic and has relatively low ionic strength, such as isotonic sugars, polyols, and salt solutions. Some representative examples are sterile water, physiological saline solution (for example, sodium chloride), bacteriostatic water, Ringer's solution, glucose or sucrose solutions, Hank's solution, and other physiologically balanced aqueous saline solutions (see eg, most recent edition of Remington: The Science and Practice of Pharmacy, A. Gennaro, Lippincott, Williams & Wilkins). The pH of the composition of the invention is suitably adjusted and buffered to make it suitable for use in humans or animals, preferably at a physiological or slightly basic pH (between approximately pH 8 and approximately pH 9, with special preference for pH 8.5). ). Suitable buffers include phosphate buffer (eg PBS), bicarbonate buffer and / or Tris buffer. A particularly preferred composition is formulated in 1M sucrose, 150mM NaCI, 1mM MgCE, 54mg / L Tween 80, 10mM Tris pH 8.5. Another preferred composition is formulated in 10 mg / mL mannitol, 1 mg / mL HSA, 20 mM Tris, pH 7.2, and 150 mM NaCl. These compositions are stable at -70°C for at least six months. The composition of the invention may be in various forms, for example, in solid (eg, powder, lyophilized form), or liquid (eg, aqueous) form. In the case of solid compositions, the preferred methods of preparation are vacuum drying and lyophilization, which produces a powder of the active agent plus any desired additional ingredients from a sterile previously filtered solution thereof. These solutions can, if desired, be stored in a sterile vial ready for reconstitution by addition of sterile Water for Injection. Nebulized or sprayed formulations are also part of this invention. Methods of intranasal administration are well known in the art, including administration of a drop, aerosol, or dry powder form of the composition into the nasopharynx of the individual to be treated from a pressurized container or dispenser containing a suitable propellant, eg a gas such as carbon dioxide or a nebuliser (see eg WO 95 / 11664). Enteric formulations are also part of this invention, such as capsules and gastro-resistant granules for oral administration and suppositories for rectal or vaginal administration. For non-parental administration, the compositions may also include absorption enhancers that increase the size of mucosal membrane pores. Such absorption enhancers include sodium deoxycholate, sodium glycocholate, dimethyl-beta-cyclodextrin, lauroyl-1-lysophosphatidylcholine and other encenn / ίζηζ / Β / γίΛΐ substances that have structural similarities to mucosal membrane phospholipid domains. The composition may also contain other pharmaceutically acceptable excipients to provide desirable pharmaceutical or pharmacodynamic properties, including, for example, modifying or maintaining pH, osmolarity, viscosity, clarity, color, sterility, stability, speed dissolution of the formulation, modification or maintenance of release or absorption in the human or animal body. For example, polymers such as polyethylene glycol can be used to obtain desirable solubility, stability, half-life, and other advantageous pharmaceutical properties (Davis et al., 1978, Enzyme Eng. 4, 169-173; Burnham et al., 1994, Am. J. Hosp. Pharm. 51, 210-218). Representative examples of stabilizer components include polysorbate 80, L-arginine, polyvinylpyrrolidone, trehalose, and combinations thereof. Other especially suitable stabilizing components in plasmid-based compositions include hyaluronidase (which is believed to destabilize the extracellular matrix of host cells, as described in WO 98 / 53853), chloroquine, protic compounds such as propylene glycol, polyethylene glycol, glycerol, ethanol, 1-methyl L-2-pyrrolidone or derivatives thereof, aprotic compounds such as dimethylsulfoxide (DMSO), diethylsulfoxide, di-n-propylsulfoxide, dimethylsulfone, sulfolane, dimethylformamide, dimethylacetamide, tetramethylurea, acetonitrile (see EP 890 362), nuclease inhibitors such as actin G (WO 99 / 56784) and cationic salts such as magnesium (Mg2) (EP 998 945) and lithium (L¡+) (WO 01 / 47563) and any of its derivatives. The amount of cationic salt in the composition of the invention preferably ranges from about 0.1 mM to about 100 mM, and even more preferably from about 0.1 mM to about 10 mM. Viscosity enhancing agents include sodium carboxymethyl cellulose, sorbitol and dextran. The composition may also contain substances known in the art to promote penetration or transport across the blood barrier or the membrane of a particular organ (for example, antibodies against the transferrin receptor; Friden et al., 1993, Science 259 , 373-377). A polylysine lactose gel complex (Midoux et al., 1993, Nucleic Acid Res. 21,871-878) or poloxamer 407 (Pastore, 1994, Circulation 90, 1517) can be used to facilitate delivery to arterial cells. Viral particles and pharmaceutical compositions can be administered to patients in therapeutically effective amounts. As used herein, the term "therapeutically effective amount" refers to an amount sufficient to effect a desired biological effect. For example, a therapeutically effective amount to treat Angelman syndrome is an amount sufficient to ameliorate one or more symptoms of Angelman syndrome, as described herein (eg, developmental delay, severe cognitive impairment, gait ataxic, frequent seizures, short attention span, absent speech, and characteristic cheerful behavior). In addition, neurons derived from SA iPSCs exhibit depolarized resting membrane potential, delayed action potential development, and reduced spontaneous synoptic activity. Thus, a therapeutically effective amount to treat SA may return the resting membrane potential of neurons to approximately -70 mV, ameliorate delayed action potential development, increase spontaneous synaptic activity, or ameliorate other disturbances of the encenn / Lznz / B / YiAi related neuronal phenotype with rheobase, action potential characteristics (eg, shape), membrane current, synaptic potentials, ion channel conductance, etc. The appropriate dose may vary depending on known factors, such as the pharmacodynamic characteristics of the particular active agent, the age, health, and weight of the host organism; the condition(s) to be treated, the nature and extent of the symptoms, the type of concurrent treatment, the frequency of treatment, the need for prevention or therapy, and / or the desired effect. The dose will also be calculated based on the selected route of administration. The professional must refine the calculations necessary to determine the appropriate dose for treatment, in light of the relevant circumstances. As a guide, a composition based on viral particles can be formulated in the pharmaceutical form of at least 105 viral genomes per cell. The titer can be determined by conventional techniques. A composition based on vector plasmids can be formulated in the form of a dose of between 1 pg and 100 mg, advantageously between 10 pg and 10 mg and preferably between 100 pg and 1 mg. The administration can take place in a single dose or in a dose repeated one or several times after a certain time interval. The composition of the invention can be included in vials, disposable syringes, or multi-dose vials made of glass or plastic. In all cases, the composition must be sterile and must be fluid to such an extent that easy syringability exists. It must be stable under the manufacturing and storage conditions and must be preserved against the contaminating action of microorganisms such as bacteria and fungi. Sterile injectable solutions can be prepared by incorporating the active compound (eg, infectious particles) in the required amount with one or a combination of the ingredients listed above, followed by filter sterilization. The viral particles and pharmaceutical compositions of the present invention are preferably administered parenterally, including intravenous, intraarterial, subcutaneous, intraperitoneal or intramuscular, intrathecal or intracranial, eg, intracerebral or intraventricular injection or infusion. In one embodiment, the viral particles or pharmaceutical compositions are administered intracerebrally or intracerebroventricularly. In another embodiment, the viral particles or pharmaceutical compositions are administered intrathecally. In certain embodiments of the methods of this invention, the viral particles and pharmaceutical composition described above are administered to the subject by subcranial injection into the brain or spinal cord of the patient or human in need thereof. In a particular embodiment of the invention, the use of subcranial administration in the brain results in the administration of the coding nucleotide sequences of the invention directly to brain cells, including glia and neurons. As used herein, the term "neuron" refers to any cell in or associated with brain function. The term can refer to any of the types of neurons, including unipolar, bipolar, multipolar, and pseudo-unipolar. light / Lznz / B / YiAi Examples General methods Human Embryonic Stem Cell (hESC) Culture and Neural Differentiation hESCs were cultured on irradiated mouse embryonic fibroblasts and fed daily with hESC media (DMEM / F12 containing replacement serum, L-glutamine + β-mercaptoethanol, non-essential amino acids and basic fibroblast growth factor). hESCs were cultured at 37 °C in a humidified 5% COa incubator. Cells were manually passaged every 5-7 days. hESCs were differentiated into neurons using a modified version of the monolayer protocol. Neural induction was initiated 2 days after passage by culturing cells in N2B27 medium (Neurobasal medium, 1% N2, 2% B27, 2 mM L-glutamine, 0.5% penicillin / streptomycin, 1% insulin-transferrin-selenium). . The N2B27 medium was supplemented with fresh noggin (500 ng / mL) for the first 10 days of differentiation. Black rosettes were manually passaged onto poly-D-lysine and laminin-coated plates using the Stem Pro EZ passage tool approximately 14 days after starting neural induction. Black parents were plated at high density around 3 weeks into differentiation, switched to black differentiation medium (NDM) around 4 weeks into differentiation, and then plated out. plated scantily for terminal differentiation at around 5 weeks. The NDM consisted of basal negro medium, 1% B27, 2 mM L-glgtamine, 0.5% penicillin-streptomycin, nonessential amino acids, 1 μΜ ascorbic acid, 200 μΜ cyclic AMP, 10 ng / mL brain-derived negrotrophic factor, and 10 ng / mL of glial-derived negrotrophic factor. The negronas were kept in culture until 10 to 17 weeks of differentiation. Protocols for hESC maintenance and negronal differentiation have been previously described. Generation of the shRNA and ribozyme vectors ShRNAs and ribozymes were generated by igniting two complementary polynonucleotides with the desired sequences. Specifically, the polynucleotides to generate shRNA were composed of the specific 21 ngcleotide sequence targeted and its reverse complement, separated by a CTCGAG strand sequence, and with a 5' flanking CCGG sequence and a 3' flanking sequence. of TTTTTG added for sg cloning into the plasmid vector. The polynucleotides to generate ribozymes were composed by the specific sequence of 41 ngcleotides together with the same 5' and 3' flanking sequences for cloning into the plasmid. The gnido polynucleotides were ligated into the vector pLKO.1 pore (Stewart et al RNA 2003 abr;9(4):493-501). ShRNA and ribozyme sequences are under the control of the U6 promoter. The resulting plasmid was subjected to Sanger sequences to confirm the correct insertion of the shRNA sequences. Lentiviral production and transdoction of neonas Lentiviral particles were made by transfecting 293FT cells with second-generation packaging systems using Lipofectamine 300. Virus was concentrated using the Lenti-X concentrator kit (Clontech) and viral titer was calculated using the lentiviral titer kit. rus qPCR pncrnn / ίζηζ / ε / γίΛΐ (abm). 10-week-old neurons were seeded on laminin-coated plastic dishes at a density of 1.3 cells per cm2 and transduced with 10 viral particles per cell. Neurons were harvested for RNA seven days after lentiviral transduction. Quantitative RT-PCR cDNA was synthesized using the High Capacity cDNA Reverse Transcription Kit (Thermo Fisher Scientific) according to the manufacturer's instructions. Quantitative RT-PCR was carried out using Taqman gene expression assays for each intended target and Mastermix (Thermo Fisher Scientific) on the Step One Plus (Thermo Fisher Scientific). Reactions were performed in technical duplicate and the GAPDH endogenous control Taqman assay was used as the housekeeping gene for normalization. Gene expression was quantified using the δδΟ method. AAV production and neuron transduction 551 shRNA 2 as well as a scrambled shRNA control were cloned into the pAV-L)6-GFP vector and packaged into viral particles by a commercial supplier (Vigene). Neurons were transduced with 551 shRNA 2 AAV9 particles using at least 1x105 viral genomes per cell. After 48 hours, images of the neurons were taken to visualize the transduced neurons. Example 1 To assess the cleavage ability of ribozymes in vitro, ribozyme and target RNA sequences were transcribed in vitro and evaluated under controlled conditions. Specifically, primers including a T7 sequence were used to amplify the predicted target genomic sequence. The POR product was cleaned up and concentrated before use in an in vitro transcription assay with T7 polymerase. The DNAs were used in an in vitro transcription reaction with T7 polymerase. RNA was column purified using the MEGAclear kit (Ambion). Ribozyme RNAs were prepared by ligation of two complementary ribozyme polynucleotides. Subsequently, they were filled in with T4 polymerase and cleaned and concentrated. Ribozymes were diluted to a suitable concentration (5 pmol / pL) in ddH20 as a working stock solution. Ribozymes and target RNAs were combined in an in vitro shear assay for 30 minutes at 37°C and visualized with ethidium bromide on a 2% agarose gel. Hammerhead ribozymes, which are catalytic RNA molecules that cause hydrolysis of phosphodiester bonds in RNAs, were first evaluated. These ribozymes are cleaved rapidly and independently of other cellular machinery, and have been evaluated in clinical trials for HIV and certain tumors. Four hammerhead ribozymes were designed to cut near the sequences targeted by functional ASOs. In vitro cutting assays revealed that the ribozymes were active and could cut the UBE3A-ATS sequence (Figure 3A). The two most active ribozymes, 551 Ribo 1 (SEQ ID NO: 3) and 551 Ribo 2 (SEQ ID NO: 4), were encoded by lentiviral vectors that were packaged into lentiviral particles and used to transduce neurons. mature iPSC-derived SA. The levels of (JBE3A-ATS were reduced to -40% (Figure 3B). pncrnn / Lznz / B / YiAi Example 2 shRNAs were developed that target similar sequences in the UBE3A-ATS gene. The shRNAs resort to the RNA interference pathway to decrease the expression of the RNAs. Four shRNAs were designed by cloning them into lentiviral vectors that were packaged into lentiviral particles and used to transduce SA iPSC-derived mature neurons. 551 shRNA2 (SEQ ID NO: 2) achieved a 40% downregulation of UBE3A-ATS and a 2.2-fold activation of paternal UBE3A (Figure 4). These studies have been replicated by cloning the same shRNAs into adeno-associated viral (AAV) vectors and packaging them into AAV9 particles (Figures 5 and 6). The foregoing detailed description and accompanying examples are understood to be illustrative only and should not be construed as limiting the scope of the invention, which is defined solely by the appended claims and their equivalents. Various changes and modifications to the modalities disclosed will be evident to the technicians in the field. Such changes and modifications, including without limitation those relating to the chemical structures, substituents, derivatives, intermediates, synthesis, compositions, formulations, or methods of use of the invention, may be made without departing from the spirit and scope thereof. sequences SEQ ID NO: 1 Human UBE3 A-ATS genomic sequence. TGAGATGACCTAAACAACTGTGGAGAATCATTGATATATTTCCTTTTTTCACTGTTCATGTTGG GTGAAAATAATCTTGTAGTGAAATTCACATGTTCTAAATATTGTTTTTTTACATCTTATCTGGTACCCC ACTTACTCCTTAAACTTTTAGTTAATTAAAGAGTTTTTATAAAGTCCCCCAATAGATTTTTTTTTTTTGAG ACATAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATTTTGGCTCACTGCAACCTCCCC ATCCTGGG TTCAAGCAATTTCCCTGCCTCAGCCTGCCAAGTAGCTGGGATTACAGGTGCCTGCCACC ACGCCCGACTAATTTTTTGTATTTTCAGTAGTGACAGGGTTTCACCATCTTGGCCAGGCTGGTCTTGAA CTCCTGACCTCGTGATCCACCCGCCTTGGCCTCTCAGAGTGCTAGGATTACAGGCTTGAGCCACTGC ACCCGGCCAGAT TTTAATCTAATTTTATTAGAACAATTCAGTCATATGTTTTTTCATGCTATGTATATGA GAGTTCCATTATTCAGATACTAAACAAATGTCTACTGTACATTTACTGTTCTCACTGATGATGCATTAG ATAACCATGCACAAAATAAGCCTGGCTGTGGAAACGCTTATTTGTTGGGAGGGTGCTTGTTTGGATC GATGATGAGAATAATT GTCTGAGGATGCTGAGGGACTCATTCCAGATGTCAATCTGAGGTCCAGATG TGCGGCCCTCCAATAGGACAAATAAGACTCTCAGAGCCTGGCTCTATTTGGGGATCCCTCAGTGACA ACATAGTACCCCTGTGAGCGTGCCTTTTCTATCTCTTCGAAGAGGGCAGTGGCATCCTGTCTTATGAG TCAGTGTGCACTTTAG TGTGCCTAGTGACCCAAGACTTGCTTTAATTGTAGATAGATACTTACATATAG GAAATATTTCTTAAGTAACAAATGAAAAACTTTAGAAGATTGAATTAAGGGTCAAGCAACTGTGATATG TCTGAAAATCTCATTAGTGTTGTGCTGAAAGAAGGAAATATGGCATGCCTCTATTAAATAATGACAGTG GAACCAAGTTTATTGCTTTGTT ATTTTTACTGTGGAGTATTTTCTAAGATTATTTTGCTTTTTTTTCTT TCATGTTTTGCTGAGATAGAAGGCCTGGAATCTGATCCTCCACTTCAGAGAACAGGGGTGAGTAGCT AAGCCATTATTCTTTTGAAATTCATATGTCATGTGCTCTTTGCTAGGTCTTTAGGTCGTTTTGTACATCTT on / ίζηζ / Β / γίΛΐ TTCAGAAGCTTATTGGAGGACATTTTCATGATATGTCCTTTTCCTCATTGAGACCCTCACCATGTCACC TACACTATTGAATCCTTATCATTTCTCTTTTAATTTTAACTCTCTTTTTGCTTTTATGGAAAAATGTAGAAT TTAAGAGAATTTTGGCAATTTCATATTGGATCAAAATGTATTGTAGTGAAATCCAGGTGTGCCAAAAT A TTAACAGATTTTCCCCATCTGTTTAATTATTGGGGTTTCAGAATAGAGACTCCATGGTTCATAATATC TTTGTGGTCATACTACATTATATTTCTGCTTCTAATTTAATTATTAAATATTGACTTGAATTAGTCTTTTC CTCATTGTTGCAACAAGGTAAGTTATATAGGAAATTTTCTTCTCTTGATGGCATGTCTGAGATAATCAT AGATATAAG ACACCTGGCTGGTTTCTAGAATGCATGTAATTTTTATTTCTTGATCTGTGTGTTGAGTAC TTGCTGTGATTGCATCATGCAAATACATTGAGCTTTACAATTTTAGTGTATGCACTTTTCTACATGTATA TTATTCTTCGATAGAAAGTAAAAAAAACTTATCGAACTAGTCAAAATATTGGTTAATACATAAAAAAAAGT CTCAAGTAGA TTGTGTATTACATGGTGCTTGTTGATTGATGCCCTCATAATAGATCAAGTGGGTTCTCT CTTTAGCACAGGGCTTTTTAGCAAATCATGTCATGAGTAGTTACTCAAGTATTTTTATTTTAACACATTT ATATTTTTTCTATGTATATTCTTAAATTTCCTTATACTTTTTTCTCTGTTATAAAAACATGCTGAACAATC TCAAGTCTTAAGGATT GCAGTATTGTCCCCACATATTCATGTATTTTGGTACTCAATTCTTTATACTTTC TTTGACAGATCACTTGAACTGGCACATGTCTCTTGTTTTGCAGAGAGGGAATTAATGTGATACCTTCAT GCTTTTCTATTCTATGTGCTACATAATTGAATATACAAGCAAATATAGTTGTTAAGATTTAGTGTGATTA TTTTCACACCACATGCAAAGA AGTTTCTCATAGATCTTAATAGAGGCCCACATGCATTGTACAGTTTAG AATTTGGGGAAATATTGATGAAGTTGGGTAAAGTATAAAGCCAAAAGTCAGAACAGTGAACTCCTTGC TTAAGGATTTCCTTGGAGATTACTTAGTCAATACACAACTGATAAATTTAAGTGCTTTTCACCTTTGAG TTCTCGACATACTAAAGCTAAAATGTGTT TCAACTTTTAATCCTGCTTCCCTGATTTTCCCTTTTTTAGT CTGAGATCAAAGAGTTTCAGCCATAAATTACTGCCAAGAGTAATCACTTCATTTTAAGAAAGCTTAACA ATATAGAAGAATATAAAATTATTTATGACAGATGTATTTTTAACCTTTTCCCCATGCTTTCCAGAGGAAA TATGTTTAATCATCTGCCCTATATTAGGGAAAAACTTTCTATGCTA ATACAAGTATCTATCAATCCATTT ATCTTTCTATATAAGATGTATTGATCATAACCAATTAACTTTACTGTAAATGAGCTTTAGATTTGACATT TTGGTAGTAATATATGTTGTACAATCTCCTGAGGTCCTATAGGTCTTGAGGTCTCTATGTCAAAAACTA TAGATGTGCCAGTGTCCTCAGTGAATGTGAAGGACACCACATTTTCCTTAGCCA TTTCTTGTTTTCAG AATAATGGTTATCAACATTTTGCTACTGCAAGATACCATACATTTATAATCGGAATATGCCAGTTTTTAT GCACTCATGCCTCTGTTTCTGTAGAGCATTCCCAGAATGAGTAATGCTTGAAAATTAGGTCCATGTGA TTTCTTTAATGAGTTATAGTCAAATCATGAAATATTCAGGTTACCATTATTTCAGTAATGTAT TAGAATG TCAAGGTAAAGTTATTCTACATTGTATATATACACACAACATAGATATAATTTATACAACATCTATATTTAT ACAACAGATATATATTTATGTATATATTTATACAACATAAAATATATTTTATTATTTAAACATAAAATATATTTATTATTTAATATAGATTCTTAAGTGATAAATATGTTTAATATTATTAAATAGTTAAAATAGGTTAT AGTTAGTACAGT GAAAATTGGCAGCCCTTTTACAAAACATATGCCATAACTATAGCATTTATCACTGAC AGTCATACCAGGATAGTCTTTTATTTCCAATCACTTAAATATTCCTAATTGCAAAAGAAATTTGAAGACT AAAATTCAGAAGTTTTGAAAGAGCCATTGCCTGGGTAAACTATACAGGTTTCAGTTTTATTTATAATAA TTATGAGGCCAGGCGCAGTGGCTCACA CCTGTAATCCCAACACTTTGGGAGGCCGAGGCGGGTGGA TCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCATCTCTACTAAAAATACA AAAAATTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAG AATGGCGTGAACCTGGTAGGCGGAGCTT GCAGTGAGCCGAGATCGCGCCACTGCCCTCCAGCCTG encenn / Lznz / B / YiAi GGAGACAGTGCGAGACTCCGTCTCAAAAAAAAAAATTATGTATATATTTATAAATTAATACTTAATAAAT TAATAACTTGTGATAGGCAATGCAAAGATGACAGTAAAAGGACAAAATTGATTAGATTGATAAAGTCCT GTTAACATGAAGAAATTGACCAGGATACCATCCACACTATAAAGTTAGGAGAAATTTATCAGGACAATTC CCTAAAATACTCTTCTCAA TTTTAACATTGTAACAGGAATTTTAAATTTTGGTATTATGTGTGTTTCCT TCCAGATAATTTGAACAGATTCATATTTGGTATTTTTAAAAGCCATATCTTTGTCCTTAGTGCTGGCAAT GTATTCTTGAGAATGAACAAATAAGAGATACGTAAAAGCATAAGAGAAGGTATCAGGTTGAAGTAGTC AATCAGTTATACAGAACACAAAGAATTTTATCTTG TATAATGTTTATATAGCTTTATAGAAGTGTGCTGA AAGGGCTATAAAACATGGACATTATTATTCTCATTGAAAGGTCCAATACGTACTGAAATACATGCTTTTA TTTTGAACCAACCACCCTATAAACGTTGTATGGCTTATTTAGATGAGAGCCCAGGTTGTGTGTGTCTG TGTGTGTGTGTGTGTGTGTGTG TGTGTGTGTGTGTGTGTGTGTGTACCTGACAGGGAAGCAAGAACATC GAGTTGCCAATGCACTCTGTCTATGGTTAGAATCATGCTGAAAACATGGCTCCCCCAGTTCTGGAATG AGCCCACAGATCAAGCATTCCCCAAAGACATAGCAGGCTCAAATCCCTGTGTACACAATATTTTATGA TTATCTTATGTCAGTACT TTCAAAGTATACAGTTTGTGTGAAGACAAATCCAATGTCATTTTCTTGGCT AGCCTATATGTGTGGTAAATCCATTATTTACTTACTTGCTTCCTGAAAATTACAATTAGATTAACAAACT GCAGCAAAGTGGGCATGATGAGATAGAGATTGAAGTGTAAGCTTATGTTAATGATGCCCTTGGTTTG GATAAACATCTA AGAGAAAAATGGAAAAACACACATGGCAGGGAAGCCTTGATAGAGCCAAAATAT AGGATTGTATGTAGTAATGCAATCCATAGATGAGCATTTGGCAGTAATATTATTTTCAGATATGGATA AAAATTGCTTAGGAGAGTAAAGAGACAAAGTTGAAAGCAGGTTTATAGTAGGTGTTGTTTTAGTGT TGATCCCTTTTTG CTCCAATAATCAAAGTGATAAATATTGAAAATTGATTCATGCAGCATTACTTACTCC ATTCTAATTTTATATATGTCAAAAGTGCCATCTCCCAAACTGTGCTATCCCCTTCAGGAGAAGAGACT CTGCTGAAGTTTATAAGGTTGACATATTGCCAGCTTCAATAATGTAAAGATGAAGTGTATACTGAATTC TTAATGCAAATAACAACTCTATTG GAAAGTAACCCAGTTATAGAAGTGCTAATTTGTCAGGAGCTGCCT TACCAAGATCATGATGAGTACAGTTATCTCAGGATTCTGAAAGATTGTTTTCCGATTTCAACTAGTCTA GCTGAATGTTCCTTGATAGAAAGAGAGGACTTTTAGAATTGGTTCAATATGATGACCTCCTGAATTATC TCACATAGCCCGTTTGTACATGCCTTTCTTTTCTCT CAGAAAATGGCACTATCATAATAGCTTTCTTAC ACAGACTTCACCTTAGGGTTTTACATTAAGGGAGGGGTCTGGTGTTTCATTTATTTTGAAGTATTTGTT GTTGATTGTGTACAGTGCTTGAGTAAAAAATTGAATATAGAAACATCTAGAATATTTTTTTAAAGGATCA GTGTTTATAAAGTGAATTATTAGTGTCAATAATGTTGG GAAAGTTTTAAGAGAATATAGGAAACTTGAA C ATTAC AC AACTAC AATG G G ACC AAATTGTG GG GTCTC ATTATAGTTAATATTTATGTATTTTTTTCC AA TTGATTTGTGTGCTTTTTTTCTGCATGTTTTTTGGCAGATAGAATGGCTATAACAAGTAACAGCATGTCA GGTAATAAAAATAAGCAGAGCCCTATTCCTTT AAAAATCTTCACTGATGGGAGGGCCATAAAATAAGT CTTAATACATTTAAAGAATTAAATTCATGTAAACCATGTTAATTTAATTCACAATGATATTGAATTAGAA ATAAGAGGAATATCTCTTGAACATCTCCTAAATGTTTGGAAATTTAAATTAGCATTTCTGACCTATTTAT TGGTTAAAAAAAGATACAAAGAAAGGAAAATTGAAAAGTCTTTTGAACTGA ATAAAAATAAAAATATAGA ATCTAAAACTTTATGGGATACTGACAAAACAGGATATAGGGAATAATTTATAGCACTGAAATGCCTATA TTAGAAAAGAAAAAAGGTTTTAAATCAGTAAATTTGTATTTTACCTTAAGAAACTTAGAAAAGAACAAAT TAACCCAGACTTAAGTAAAATAAAGGCACTAATAAAAGATAAGAGCAGAAATCAATGAAATATAAAACAA CAAAA CACAGAGAAAAATTGAGAAAATTTAAAAAATAGCCTAGTGAGAAGATATTGATAAACTTGTAACC encenn / Lznz / B / YiAi AGACCAATTTAAGAAAAAAAAGTCAAAAACACAAATACCAATATTTGAAAATGTAGGAGGGCAAATCATTA CAGATTCTATGAATACTAAATGATAATAAGGAAAAATTATTTAAAAGGGGCATGTCAGCCAGGCATG GTGGCTTACCCCTGTAATCCCAGCACTTTGGCAGGCCGAGGTGGGAGGATTGCTAGAGCTCAGGCA TTCGAGA CCAGCCTGGGCAACATGTTGAAACCTTGTCTACACAAAAAAGTACAAAAATTAGCTGGGTGTGGTGTTGCACACTTGTAGTCCCAGTCACTTGGGAGGCTGAGGCGAGAGGATCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAGCCATGTTTGTACCACTGCCCTCCAGCCTGGGTGACAAAGTAAGACCCTA TGTA AAAAAAAAAAAATGTATGCCAACATTTTCAATAACTTAAATGAAATGGAAAAAATTCCTTGAAAGA CACGAACTACAAAAACTCAGTGAACAAGTAAATAACCTGAATAGCCCTGTATCAAGTAAATTGAATTTG TAGTTAAAAAGCCTTCCAACAGAGAAAACTTCAGGTACCTATAGCTTCATATGAAATGAAAAAAAAAATA CCAATCCTCTACAAGATTCCAGAACAT TTAAAAGAAGGGAATATTTCCCAACTTATTCCATTTGGACAG CAATACCCAGGTAAGAAAAAGAGACACAGAAATTTAAAAAGAAGAATATATACATTATTCCTTAGGAACAT AAATGCAAAGAAATCTAATCAAAATTTTGGCAAATGAAATGTAGAAATACTTTATGACCAAGTGAGAGT TACCCAAAGAATTTAAGGTTGGTTTTATATGTAAAGATCAAC CAATATAGGAAAATCACTTCTGGAAAG TCAGAGTAAGAAACTCCAAAAATCTACTCTCTCATAAAACCAATAACAGCCTTGATAGAAATAGTTGAA ATTAATTTTCCAAAACTTTGGAAATTAACCAAAGGCTTACAAAATTCCAGAGAACATTAATTCAAGAAAA ATGGCTGAATCAGTAAGAACAGCCAGCTTTGTGGCATTTTAATATGACCCCTTCCCATG CTTTTCTCC CTAGTGCTGAGATAGTCTTAAAAATTAGCAGGATAGCAACCACTGGAGAAGAAAGGTTTGGAAATTTC CCAAAAAGTTCCATCCCCATAGAATTATCACTATTTGACCTCTAAAGCCCAATCTATAGGATTTATATT CATTTGGACTGACTCAGAGCTCACTCAGTAAGGAAATCTCAATTTCAAGGTATTGGTCAAAAAGAATC CATGGCAA TTGTTGACTATCACAACTGCCTGAAGTCTTGGTAACAGTTGGGATAAACAAGAAGCTGAT CAAAAACTGAAAACTAAAATCTTGGGAATGAGATATCTACAGGATGCTTCAAAAAGCTTTGATACATTC CTGTTTATCTAGAAAGCTACATGCAGGCTGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGG GAGGCCGAGGCG TGCGGATCATGAGGTCAGGAGTTTGAGGCCAGCCTGACCAACATGGTCTCTACT AAAAACACAAAAAATTAGCCAGGCGTGGTGGCGTGCATCTGTAATCCTAGCTACTCAGGAGGCTGAGA CAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCAAGATTGTGCCACTGCACTCCA GCCTGGGCGAC AGAGCAAGGCTCTGTCTCAAAAAAAAAAAAAAAAAGCCACATGCATGTAATTGTT TACCTCTGGCTTTCCTTTTATGCTCTGGGCAAGCTAAGGAAGAGTTGTGAACTACCTAAGTGCTGAAT GGGAACCATAACACACACACACACACACACACACACACACAGCACCTTAGTAAAGGGTGAGAGGC ATGTTAGTTAGAAGCATTAAAG GAAATCTCTTTCTAGTCATTATCTGTGCACTAACCTAACTGAGCAGA GACTTCAGTATCCATACTACAGGGCATATAAACTTTTACAGAATTAGTCCAGGAAAATCATATCTAAAAAAAAAAAAAAGCAGTAACAAAAATAAACTCTGGGAAAGGGGAGAATATGATTTAAAGAGTTGCCACA TTATACATAATATGTCTAGTGTTCAACAAAAAAATTACG AGACATGCAAAGAAATAGAAAAATATGGCAC AAAGAGGATAAGATGAAGTCAGTGAAACTATCCTCGAGGAAGACCAGATGTTGGTCTTACTAGACAC AGACATTGAACCAGCTATTAAAATACGTACACAGAACTAAGAAAAAACATGTCAAAAGGGTTAAAGAA AGGTATAAAAATAGTGTCTTACCAAATATAGACTACCAATAAAGAGATAGAAATTATA AGAAAAGACAA CATGAAAAAATATAAAGCAAAAAATTAGACAATTGAAACAAGAGGGCCTCTATTCGCAGATTTGAGC AGGCAGAAGAAAGAATCAGTGAACTTGAAGATATGTCAACTGAGATTATCCAGTCTGAGCAACAAAG GTGGGAAAAAATGAAGAAAACTGAGCAACAAAGAACTGTAGAACAGCATCTCTCATACCAATGGATAC encenn / Lz nz / B / YiAi ATAAACTGGAGCCCTAGAAGGATGAAAAAAGGAGAAGGAAAGAAAACTTCCCAAATTTTAAGAAAAAC ATTAATTTATATACCCGAGATGACCAATAAAATCCAATTAAGATAATCTCAAAGAGACCAACACCTATA CACATCATAGTCAGCGTGTCAAAAGACAAACATAAGGAGAGAATTCTTGAAGATAGTAAGAAAAAAAAT TATTCATAACATACACACCATCCTCAATAAGTC TGACAATTGACTTCTCACTGTAAACCATGCAGGCTA AAAAGGCAATGTACATAACCAAAGTGATGAAATAAAAACCTTCAACCAATCATTCTAGATCCAACAAAA CTATTGTTCAAAAAGAAGAAATGAAGACATTCCTAAACAAAATCTCAGAGAAATGTTCTCTATAAGACT TGTCCTAATAGAAATGCTAAAGGAACTCCTTCGGTCTGAAATAGAAAGG CACTGGAGAGTAAATCAAA TCCACGAGAAGAAATAAAGAGAACCAGTATAAGTAACTACATGTGTAAGTTTAAAACAAAGTATAAATT TATTTTGTTTGTAACATTTGTCTTTTCCTATTTGATTTAAAATATAATCTCAATTATAAACTTGTGTTGAT GGTATTATATAAAGATGTAATTTTGGGTTATAGCACCAAAATGGCAGAATAGGAATTTTC C TTCCACAGAGGAAAAGGAGAGTATAATAAGTAAGTGTCCAGTTTTCCAAGACATACAGGCCCCTGC CCAAGAGATCCACTTTATTTTCATCTCACCCAGAATATTGAGGTGATCAGCAAGGTGGAGTGGTTGGG AGAGGGTAAAAGCAGGAAAGAGAGATGGGGACTCAAACAGCAGCCCATACTTGGAACTGCCATAGA TCCTACCAGTTACT TCATGGACTCCATCAGGAACCCACCTATAAGCCACAGGGGATGCATCCCTCCC ATCTTGCCAACAAAACCCCGAATGCTCCAAATGCCTCACCCACTCTTTGGCTGGCTCCCAAGTGCGC TCCTGTGAAAAGCGAGTGAGTATCTCTGCAGATGGCTTGCAAGCACATGTTGACAGCTGGCTCCACT CTGTAGAACTGGAAAAAAGCTCA CATACATGAGAATTTCAGGACACTACCCTAAAAAAAAAAAATGAGA CTTCAGCACCTGGCCTGGCTTTATGCAACCTAGAGAAGGTGATATGATTTGGCTCTGTGTCCCCACGTAAATCTCATGTCAAATTGTAATCCCCACGTGTTGGACAAGGGACTTGGTGGGAGGTGATTGAATCAT GCGGGTGGACTTCCCTCTT GCTGTTCTTGTGATAGAGTTGTTATGAGATCCAGTTATTTGAAAGTATG TAGCATGTCCCCCTTCACTCTCTTGCACTCCTGCTCCACCTTGGTAAGACTTGCTTGCTACCCCTTTGCCTTCTGCCATGATTGTAAGTTTCCTGAGGCCTCCCAGCTATGCTTCCTGTATGGCCTGCAGAACTGA ACTGTGAGCCAATTAACCTC TTTTCTTCATAAATTATCCAGTCTTAGGTAGTTCTTTATAGCAGTGTG AGAATGGACTAATGCAGAAGGCATACAACCTTTAGAATTTGCCCCCTTGAGGGAACAAGATGTGTGA AGCAGGTTCATCCATAGAAAATGTCTGAGAGAACCTCAAAATCCCTAACCTGACTAACTGATGAAAGT GTTTCTCTCCTAAGGCCAGTCAGTAAAGACC AGAGGGGGTGACTGTTTCTTTAAATGCAAAGGCAGC AGCACAATAATTCAAGAAACATGAAAAATCAAGAAAACATGACACCACCAGAAGAACACAATCATTTTC CAATAACCAACTCCCCAAAAATGGAGATTTACAAATTGGTTTATAATGAATTCAGAACAATTATGTTAA GGAAGCTCAGCAAACTAAAAGGAACACCAATAGACTACTCTGTGAAGTCAG GCAAACAATTCATGAAC AAAACTAGAAATTCAAAAAAGAGAAAAATTATCTTAAAAGAAAACCCAGAAGTTATGGAGCTAAAGAAT ACAATGCATGAAATGAAGGAGCGTATCAACAGCAAAGTTGATCAAGCATAAGAAAAAAAAAATCTGTG AAACTGAAGACTGGCTATTTGAAATTATTCATCAGAGGATTAAAAAAAAAAGAATGAAAAGAAATAAAG AA AGCCTACAGGATGTATAAAACACCATCAAGAGAACTAATATAAGGATTATTGGAGTCATAAAGGAG AAGAGAGAAAAGGGTAGAAAACTTATTTAAGAAATAATGGCTGAAAACTCTCCAAATCTAGGAAAAGA TATGAGCATCCAGGTATATGAAGCTCAAAGATCCCCGTACAGGATACATTCCAAAAAGACTTCACCAA encenn / Lznz / B / YiA i AACACATGATAATCAAACTGTCAAAAGCAAAATCAAGACGATGAATAAACCACCAATCACTAAGAGGG AGACAGGATTCTTATGTTGTCATTATTATTTACATATAATTTCAGTAAATGTTATTGGAAAATTTATAATG TTTTAAAAAAAGAAATTTGAAAGCACCGAAAGAAAAGACTCATCACATACAGGGAACCCTTTTAAG GCATTCAAGAGATTTC TCAGTAGAAACCTTACAAAATAGGAGAGAGTGGGATGAACTATACAAGTGCT GCAAGGAAAAAAATGCCAACCAACGCTTTACCTGGCAAATCTGTTCCTCAGAAATGAAGGAGAGAGA AGAACTTTCCTAGACAAACAAAAGCTGAGGCAGTTCATCACCACTAGACCTGCCTTACAAGACATACT AAGGGGAGTTCTTCAAGCTGAAATGATATGGCA ATAGTTAGTAATATGAAATGATAAACCTCACTGGT AAAGGAAAGTACATAGTCAAATTTAGAACACTTTGATACTATAATGATGGTGTATAAATAATTTTACTGT GCTATGAAGGTTAAAAGACAAAAGTATTAAAAAAACCCATAGCTGCAATAGCTTGTCAATGCATACTA CAGTATAAAAAAGATGTAAATTAGAACATTAAAAACATAGCATG CAAGGGTAGGGAAGTAAAAGTGTAG TTTTCATATGTAATCAAATTTAATTTGTTATCAGCTTAAAATAAATTGTTATACCTATGTTTTATGTAAGT GTCATGGTAACTATAAAGGAAAAACCTCTAGTAGATACAAAAGAAAAAGAGAAAGGAATCAAAACA TAACACTACAGAAAATTATCAAATTACAAAGGAAGACAGCAAGGGAGGAACAAAGTAAA AAGAGCAAG AAAAAATTTAACATAATGAAAACAGTAAGTCCTTACGTGTCAATAATTACTTTAAATGTAAATGGATTAA ATTATCCAAACAAAAAAACAGACTGGACAAATGGATTTTAGAAACAACAACAACAACAAACACCGCAC ACACACACACACACACAACCACCCAGCCCCAACTATGTGCTGCCTACAAGATTACTTCCACT TTAAGGACACATACA GGCTGAAATTAAAAGAACAGAAAAAAGATATTGCATGCAGATAGAAACCAGAAG AGAGGAGAGGCATCTATACTTACAGCATACAGAAAAGATTTTAAGTTAAAAACTATATCAAAAGGCTAA GAAGGTCAAAATGGTGAAGCAGTTAATTGTTCAAGAAGACATAAAAATTGTAAATATTTATACACCCAA TATTGAAGCACCTAAATATATAAGGCAAATA TTAATACATATAAAAGGAGAAATATACAGCAATACAGT AATAGTAGTGAACTTCAGTGCCTCCCTTTCAAAAATGGATAATCCAGACATAAAATCAATAAGGAAACA TTTAACTTAAACTTCACTTTAGACCAAATGGATCTAACAGACATTATACTGAACATTTCACTCCAACAGT GGTAGAATTCACATTCTTCTCAAGCACACATGGAACATTTCCCAGGATAGATTATAT GTTAGCTCACAA AATAATATTACAAAATTTAATAAAGCTGAAATATCAATTATTTTGCACCACAATAGTATAACACTAGAAA TCAATAACAAGATGGAAACTGGAAATTTACAAATATATAGCATTAACATATTCCTGAACAACCAATGGG TCAAAGAAAAAATCAAAATAATTTTGTGACAGCAAAGTAGAAACACAACATACCAAACATACATACAGGAC ACAGCA AAAGCAGTTCTATGAGGTAAGCTTATATTGATAAACACATTTAAAAAAAGATTTTAAATAAAC AACATTACACCTCAAGGAACTACAAGGAAGAAAAAAAAACAAGCCCCATGTTATCAAAGGGAAGGAAC TAACAAAGATCAGACAGAAATAAATGAAACATAGACTAGAAAAACAATAGAGACTATTAATAAAACTTA GAGTTAGTTTTTAAAAAATAAAATCAACAAACCT TTAGCTAGACTAAAAAAAAGAGAAGACTCAAATAA AATAAAAAATGAAAGAGGAGACATTACAACTGATACCACAGACATACAAATTAAGAGAAAACTATATGC CAACATATTAGTTAACTTGCAATGGGTAAATCCCTAGAAACATACAACCTACAAAAACTGAATCATGAA GAAATGGAAGATCTGAACAGATCAATAATGAATAAGGGAATTGAATCAATATTCAAAAATCTCACAA AA AGAAAAGCTCAGGATCAGATGGCTTCACTGGTGAAGACTGCCAACCATTTAAAAAAAATTAATACCACT CTTTATTAAGCTCTTCCAAAAAAATTGAAGAGGAGAAAACACTTTCAAATTCATTATAAGAGGCCAGTT TTACCTTGATATCAAAGATTTAAAAAGAACACTTTGAGAAAGGAAAATTACAGGCCAAACCCTTGATA AATATAGATGCAAAAATGCTCAG CAAAATACTAGCAAACCTAATTCAGCAACACATTATAATGGCATAC ATCATGACCAAGTGAGATTCATGCCTCGGATGCAGGATAGTTCAATATAATCAAATCAACAAATGTTA encenn / Lznz / B / YiAi CACTACTTTAACAGAATGAAGGATAAAAATCATATGATCATCTCGATGGTTGAACTAGTTTACAGTCCC ACCAACAGTGTAAAAATGTTCCTATTTCTCCACATCCTCTGCAGCACCTGTTGTTTCCTAACTTTTTAC AGATCACCATTCTAACTGGTGTGAGATGGTATCTTTATTGTGGTTTTGATTTGCATTCTCTGATGGCCA GTGAT GGTGAGCATTTTCAAGTGTCTGTTGGCTGCATAAATGTCTTCTTTTGAGACGTGTCTGTTCAT ATCCTTCACCTACTTTTTGATGGGGTTGTTTGTTTTTTTCTTGTAAATTTGTTTGAGTTCTTTGTAGATT CTGGATATTAGCCCTTTGTCAGATGAGTAGATTGCAAAAATTTTCTCCCATTCTGTAGGTTGTCTG TTC ACTCTGATGGTAGTTTCTTTTGCTGTGCAGAAGCTCTTTAGTTTAATTAGACCCCATTTGTCAATTTTG TCTTTTGTTGCCATTGCTTTTGGTGTTTTAGACATGAAGACAGTGTGGTGATTCCTCAAGGATCTAGAA CTAGAAATACCATTTGACCCAGCCATCCTGTTACTGGGTATATACCCAGAGGATTATAAATCACGCT G CTATAAGCCATAAAAAATGATGAGTTCATGTCCTTTGTAGGGACATGGATGAAGCTGGAAACCATCAT TCTCAGCAAACTATCACAAGGACAAAAAACCAAAACACCGCATGTTCTCACTCATAGGTGGGAATTGAA CAATGAGAACACATGGACCCAGGAAGGGGAACATCACACACTGGGGATGGTTGTGGGGTGGGG GG AGGGGAGAGGGATAGCATTAGGAGATATACCTAATGCTAAATGACGAGTTAATGGGTGCAGCACACC AACACGGCACATGTGCACATATGTAACAAACCTGCACGTTGTGCACATGTACCCTAAACTTAAAGTA TAATTAAAAAAATAATGCTGCTATAAAGACACGTGCACACGTATGTTCATTGCGGCACTATTCACA AT AGCAAAGACTTGGAACCAACCCAAATGTCCATCAATGATAGACTGGATTAAGAAAATGTGGCACATAT ACACCATGGAATACTATGCAGCCATAAAAAAGATGAGTTCATGTCCTTTGTAGGGACATGGATGAAGC TGGAAACCATCATTCTCAGCAAACTATCACAAGGACAAAAAACCAAACACTGCATGTTCTCACTCATA GGTGG GAATTGAACAATGAGAACACTTGGACACAGGAAGGGGAACATCACACACTGGGGCCTGTCG TGGGGTCAGGGTAGGGGGAGGGATAGCATTAGGAGATATACCTAATGTAAATGACGAGTTAATGGGT GCAGCACACCAACACAGCACATGTGTGCACATGTACCCTAGAACTTAAAGTATAATAAAAAATAAATC ATATC ATCATCTCAGTAGATTTAGAAAAGCATTTAACAATATTCAACATCCTTTCAGAACTAAAAACTCT CAATAAATCAGGTATAGAAAGAATGTGCCTCAACACTATAAAAGCCACATATGACAAACCTGGAGGTA ATATACTCAATGGTGAAAAGTAAAAAAGCTTTGACTCTAAGATCAGAACCAAAACAAGGATGTCCATTCT CACCACTTATATTTAACATAGTAGTTGAAATT CTAGCTAGAGCAATTAGGCAAGAAAAAAGGCACCCA AGTTGGAAAGAATGAAGTTAAATTGTCTCTGTAGATGACATGATCTTATATATAGAAAACACTAAAGAC TCCACCAAAATGCTGTTTTAATTAGAGCTTAAAAAAAATAATTCACTAAAGTTGCAGGATACAAAATCAG TATACAAAAATCAGTTGCATTTCTAAACACCAAAAACAAGTTATCCAAAAAATT AAGAAACAATCCTAT TTGTGATATCATCAAAAAATAAAATACTAAAGAATACCAAAGAAACTGAAAATAAATGGAAATAAATGG AAAGATAGCCCATGTTCATGGATTAGATGAATTAATACTGTTAAAATGTTCATACTACCCAAAGCAACC TACAGATTAAGTGCAATTCCTACTAAAATTCCAATGACATTTTTCACAGAAATAGAAAACACACTCCTA AAGTTT GCATGGAACCGCAAAAGACTCAAATAGATGAAGCAATTTTGAGCAAGAACAGTAAAGCTGGA GACATCACACTACCTAACTTCAAAATTTTATTAATCAAAACAGCATGACATAAAAACAGACAGAAAAGA CCAATGGAACAGAATAGAGAGCCCAGAAATAAACTCACGTTTATAGAGTCAACTAATATTCAACGAAG GTGCCAAGAGTACACAATGGGGAAAG TATAGTCTCTACAATAAACAGCACTGGGAAGACAATATCCA AATGCAAAAGAATGAAATTACACCCCTTATCTTATACCATACACACAAATCAAATCAAAATTGATAAAGA CTTAAATATAAGACCTGAAACCATACAATCTTTAGGCAAAAACTCATTGACATTGGTCTTGGCAATGAT TTTTTTGATATGACACCAGAAGCACAGGCAACAAAAAGCAAACCTAAACA AGTGGGACCCTAACAAACT rncrnn / Lznz / B / YiAi AAAAAGTTTCTGCACAGCAAAGGAAACAATCAATCATCAGAATTAAAAGGCAATTTATGAAATGGGAG AAAATGTTTGCAAACCACATATCTGATAAAGGGTTAATATCCAAAAATATATAAGGAATGCATAAAATT CAATAGAAATAAACAAAACAAATAATCCAATTTTAAAATGGGTGAAGAACCTGAATAGACATTTTTTCAA AGAAGACTTACA GATAGGCAACAGGCATATGAAAAAATGCTTGACATCACTAATAATCAGGGAAATGC AAATCAAAGCTCCAGTGAAATACCACCCTCCAACTATTAGGATGGCTATTATTCAAAAACTCAAAAGAAAA CAAGCTGGGGGAATGTAGAGAAAAGGGAAAAGAAGATCCTTATACACTGTTGGTGTGAATTTAAACT GGAATAGCCCTTATGGAAAACAGC ATGGAGGTTCCTCAAAAAATTAAAAATAGAACTACTATATGATC CAGCAATTTCACTATTGAGTATATATCCAAATGAATTAAAATCACTGTCTTGAAGAGGTATTTGCACAC TCATATTTATTTCAGCATTATTCACAATAGCCAAGACATGGAATCAACCTAAGTGTTCATCAGTAGATG ATTAGATAAAGAGAACGTGGTATATAGACACAGTGGAAT CTATTTAGTGTTCAAAAAGAAGGAAATCC AACTTTTAAAATCCTTTAAAAAGTTAAACTCATAAAAACAGAGAGGAGAATGGCGGTTTCCAGGAACT GGAGGGTGGGAGAATGGGGAGATGTTGGTCAAAAGGTACAAACTTTCAGTTATAAAATGAATAAGTT CTAGAGATCTAGTGTACAACAGCATTACTATAGTTAATAATAATATTTTTTATACTTGA AATTTGCTAAG AGTAAATATCAATATTCTCAATACACACAAAACAGAACTATCTGAAGGCACTGATATGTTAATTATCTTC ATTATAGTAATCATTCACAATGTATAATGAATATCAAAACAATAGTGTACATCTTAAATATATACAGTTT TGATTTGTTAATCATACATCAATGAAGCTAGAAAAAATGTTGTAATTTTTAAAACAATAGTAATATAAAT TAGG GGTGAAGGAATTGACCTATGTTGGAGAAAAGTTTTTGTAAACTATTTAAATTAATTGGTATCCAT TCAAGCTAGATTATTTTTAATTGTTAATTTAATTGTAATACTAAGGCAACCACTAAAAAAGCCTTTAAAA AAATATAGCACTTGAGGCTGGGCATGGTGGCCCTCAATTATATATATAATATATATAAAATATATATTAT ATATATA GTAGATGAACAACAATGGGATTTAAATGGTACACTAGAAAATATCTGTTTAACAAAAAAGAAA GCAATAGTGGAGAAATATAAGAACAAAACCATGTAAGATTTATAGAAAATGAATAGCAAATTGGTTGAC CTAAACCCTATCTTATAATTATATTAAAGATAAATGAAATAAATACTACATCAAAAGGCAGAGATTATCA GAATAGAGAAGAAAAATCCAAACC ATAATTCAACCTTATGTTATCTGTATTTAGAATATTTAGAGTCAA GACACAATAGATAGAGTTCCATTTGGGCGTGAAAATATTTACCATGCAAAATGTAATTAAATAGAGC TAGAGCAGCAATACTAATATCTGACAAAATATACTTTAACAAAAAATTGTTGCTAAAGACAAAAAAGAAC ATTTTATAATAAGACACAACAATTATAAACATATACACCAAACAATAGAGCC CAAAATATACAAAGCAA AAACTGCTAGAATTGAAGAAAGATAGAAAAATCAATGATTACAGTTGGAGGTGTCAATACCAAACTTTC AGTAATACACAGAACAACAAGTCAAAAGCAAAAAGGAAATAAAAAACTACACATTATCATACAACACCT TAATACGATATCCAACAATAGCAGAATACACATTATTCTGAAGTGCACATGGAATATTCTTCAGGATGA CACATATT AGGCTGTAAAACATATCTTAATAATTTAAAAGAATTGAAATAATACAGCATATTCTCTGA CTGCAAAATATTAAACCAATTACAGAAGAAAATGTGGGAAATTCACAATGATATGGAGATTTAAAAATA CTTCAAAGTAACCAATGAATCAAAGAACAAATCACAAGAGAAATTAGAAAATATTTTAGATGAATAAAA CTGAAGAAACAACATACCAAAATTTTGTG GTTGTAGCTAAAGCAGTGCTTCAAGGGAAATGTATAACA GTATATCCCTAAATTTTAAAAAATCTCAATCCAATAACCTAATTTTTCACCTTAAGAAATGAGAGTGAA AGAGCAGACTTAACCCAAAGTAAACAGAAGGAAGAAATAATAAAGATTAGCATGGAGATAAGTAGTGA AAATAAAACAATAGAGAAAATTAATAAACTTGAAAGTTGGTTCTCT GATATATCAGTAAAATTGACGT ATTATTAGTTTGACCGAGAAAGAACAAAAGAGAGAAGATTCAAGTTACTAGACATAAATGAAAGTATAG ATATCACCTTACAGAAATTAAAAGAATTCTAACAGAATATTGTGAAAAAGTGAATGTCAAAAATTAAAT pncrnn / Lznz / B / YiAi TATATGAGATACAAATCCCTCTAAAGGCACAAACTACCACAGCTGGTGTAAAAACATGAATACACC ATTTACAGTTAAAAAGACTGAATAGATAAAAATTTTAAGAAGAAATTGAGTAAGTAATTTAATTTTCAAA CTATAATCCCAAAGACCAGATGTTTTCATTGGTGAATTCTACCAAACTTTAAAAAGGATTAATATCTATTTT TCATACACTCTTTCCAGA AAATAGAAAAGGAGGGAACACTCTATAACTCACTGTATGAGGTCCGTATT ACCCTTATATCAAGACCAAACATCATAAGAAAAGAAGACTAAAGACTTATGGTTTCTGCTCTGATATGT TTGGAAGTCATCACTACTATTGTCACAAGGAAAAATCTGAACAACTAAAGTCAACGATTTCTTAAACT AACCATAGAATTGAGGTAACGGGCGAAAACTGGAGAT GTAGGCAAATACAAAAAAAATCACAGTTTAT CAGGAGCAGAAACTGCTGAAACCAGCAACTCGTATGAACATGTTAAGTGGTAATTGACAAATTTCTGG AGATTGAATGTGGACTGGATTGAGAGTTAGGAACTCCTAAGTGCCCAGTTTTGATGACCCCACACAC TTTTGTAAACTAGACTTCCAAGAGCCCCAGCAAGTTTCTTACAGTGAAG ACTGCAGAAAAATCCCCTG ATGCTTCAGATAGGAGGAAGGGAAAAGCAACTATTTTGAAATAAGCCCAGGGGACAAGTAGTTATTTC TAAACACTCTCAGAGCATTTTCTTTCACACGGCAGGGGGCTCCCTGCAAGGGAAGCTACTTTGCCTG AGCCTTGTCTGATGTAGGAGAAAAGGAATTGGATGGCTCAAGCTCCATCTAGCCTTT CTGATTTATAT AAGGGAAGCAAAAAATAGGTTAAGAAACTCTTCTGAAAGTCACAACTCAGATTTATTTTATATTTATTTA TTTATTTATATTTTTTGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGATCTCG GCTCACTGCAAGCTCCACCTCCCGGGTTCACGCCATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGA C TACAGGCGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCACGTTAGCCAGGATGG TCTCGATCTCCTGACCTCGTGATCCACCTGCCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAG CCACCGCACCTGGCCTCACAACTCAGATTTAACCATAAGATTATAGAACACTTCTCCTCCCAAAACAG AGATATAGATCAAT GGAACAGAACAGAGCCCTCAGAAATAACGCCGCATATCTACAACTATCTGATCT TTGACAAACCCGAGAAAAACAAGCAATGGGGAAAGGATTCCCTATTTAATAAATGGTGCTGGGAAAAC TGGCTAGCCATATGTAAAAAGCTGAAACTGGATCCCTTCCTTACACCTTACACAAAATTAATTCAAGA TGGATTAAAGACTTAAACGTTAGGCCTA AAACCATAAAAACCCTAGAAGAAAACCTAGGCATTACCAT TCAGGACATAGGCATGGGCAAGGACTTCATGTCTAAAACACCAAAAGCAATGGCAACAAAAGACAAA ATTGACAAACGGGATCTCATTAAACTAAAGAGCTTCTGCACAGCAAAAGAAACTACCATCAGAGTGAA CAGGCAACCTACAAATTTTCAACACCTACTCATCTGACAAAGGGC TAATATCCAGAATCTACAATGA ACTCAGACAAATTTACAAGAAAAAAACAAACAACCTCATCAAAAAGTGGGCAAAGGATATAAGCAGAC ACTTCTCAAAAGAAGACATTTATGCAGCCAACAGACATGAAAAAATGCTCATCATCACTGGCCGTC AGAGAAATGCAAATCAAAACCACAATGAGATACCATCTCACACCAGTTAGAATGGCGATCATTA AAAA GTCAGGAAACAACAGGTGCTGGAGAGGATGTGGAGAAATAGGAACACTTTTACACTGTTGGTGGGAC TGTAAACTAGTTCAACCATTGTGGAAGTCAGTGTGGCGATTCCTCAGGGATCTAGAACTAGAAATACC ATTTG ACCC AG CC ATCCC ATTG CTAT ATATATATATAT AT ACCC AAAG G ACT AT AA A TC ATG CTG CT AT AAAGACATATGCACAGGTATGTTTATTGCAGCACTATTCACAATAGCAAAGACTTGGAACCAACCCAA ATGTCCAACAATGATAGACTGGATTAAGAAAATGTGGCACATATACACCATGGAATACTATGCAGCCA TAAAAAGATGAGTTCATGTCTTTTGTAGGGACATGGATGAAATTGGAAATCATCATTCTCAGTAA ACT ATCGCAAGGACAAAAAACCAAACACTGCATGTTCTCACTCATAGATGGGAATTGAACAATGAGAACAC ATGGACACAGGAAGGGGAACATCACACTCTGGGGACTGTTGTGGGGTCGGGGGAGGGGGGAGGGA TAGCATTAGGAGATATACCTAATGGTAAATGACGAGTTAATGGGTGTAGCACACCAGCATG GCACAT encenn / Lznz / B / YiAi GTATACATATGTAACAAACCTGCACATTGTGCACATGTACCCTAAAACTTAAAGTATAATAATAAA AAAAGGCTACCTAAAAAAAAAAAAAAGAACACTTCTCCTCCCAACACCATATCACCATCAACCAGG ACTCCAGTGTAATAGCAGTGAATTCTAACTGAAAGAGGTGAAAGACACTGATTGTATTTAAGAAAGAT CTTCTAAGGAAATCCAAAAATA GTAGGGGATCAAACAAAGATACTAGAGGAAATTGAATATGTGA CACCTATAGCTACAAAAAAATTAAACATAACATAGCCCTAACCATATAAACATAAAACCTCACACAAAG ACCTATTATCTGAGATTCTGTTGCCTGATACATTGCGTTTTATTCAATAAAAAAAATTAGAGGGTATGTT AAAAAAGCAGGAAAAGTTAGTCTAAAGAGACAAATTGAGCCT CAGAAGTAGGCTCAGATATGGCAGAG ATTTGGCAATTATACCTAGAGTTTAATATAAATGATTAATATAATAAGTGTTCTAACAGAAAAAGGCAAC ATGCAAGAACGGATGGGTAATGTGATCAGCAAGAAGGAAACTCTAAGAAAGAAGTCAAAAGGAAATG CTAGGAATAAAAACCTACAAGAAATAAAGAATGCCTGTGATGGGTTCC TCAGTAGACTGGACAAGGTC AAAGAATCAGTGGATTTGAAAATATGTCAACAAAAACTGCCCCACTGAAATACAAAAGAAAAATAGAAT TTTAAAAACGTAACACAATCTCCAAAACAGTGGGACAATTACAAAGATGTAATGTGCCTAATGCAAAT GACAGTAGGAGTATAAAGGGAGAAAGGAATAGAAAATCTGAAGTAATAATGGCAGAGAGTTTT CCAAA ATTAATGCTAAACCACAGATACAGCAAGCCCAGAGAACAACAAGGAGGAAATTTAGTAAAGCGTCTG CAACCAAGTATGTCATATTCAGACTGACAAAACCAAAGGTGAAGAGAAAATATTGAAAGAAGACAAAG AGGAAAATAAATATCAAGAAAATACATACGAAATACATCATACATACATAAGAAATACATCAGACCATA CAAGCAAGAAGAGAATGGAGTGA AATGTTTAAAATGTTGAAAAAAAAACTATCAATTTGCAATTCTGTA TCCAGTGAGATTATCTTTCAAAAGTGAAGAGGGAAATGGCAGAGAAGTCATCTCCAAGACCTATGGTT TCCCTTCACAGAAACACTGAAAAATATGAACAAAAGTGGTCAGAATTAACTTTCTAAGAATTCTATAAA ATGGTAAAATGTTTACACCAGTAAAGCAAATGCT GAATTGAGAAGGCAACTTAAAAAGGTGAAGAAAA CTTCGTATTATTTTTATGTGTCCTTGCCCCACGTCCTTCCCTACCTTAGTCTTGAAGATGGCAGCCCA CATTTCTACTGTGGGGCTCTGGTTTCTGTTTCCTGGTTCAAGAGGGAGAATAACAGACCTTACTTTTA GTCATTATTATTCCTTCTTTCTGATTTCCTTGGGTTTATTTTG CTCTTCTTTCTACTTTATTGAAATGAG AACTAAGATTATGATTTGAGACATTTTTCTAATGTAAGCATTTAGTGCTATAAATTTCCATCTCAACACT GCTTTAGTCACATCCCACAAATTTTTATATGTTGTAATTTCACTTTCATTTAGTTCTATTTTAAATTTTT TCTTTTTATACTTCCTCTGACTCACAGATTACTTAGAATTGTGTTGTTCAGTTTTCAAGG ATATTGTAGA TTTTCCTGTTTCTCTGTTGTCTAATAGTTCTGTTCCATTTTGTACAGATAGCTCACGCTGTATGATTTCA ATTTTTTAAAAAATTGTGCTTTGTTTTATGGCCCAGATATGGTCTGTGCTGTGAATATTCCATGTTATTA TAAAGTATGCCTGTTATATTATTATATATATATAATATATATAATTATAAAGCATGCCCGTT TTGTATTGT TAGCAGAGTATTCTAGAAATGTCAATGAGATCTTGTTGGTTGATGGTGCTTTTCAGTTCTATATCTTTG CTAATTTTTTTTTTTTTTGCTTAGTAGCTATATGAGATTCTGAGAGAGGAAATTGAAGTCTCCAACCATA ATTGTGGATTTGTCTATTTCTCCTATCAGTTCTATCAGTTTGTGCATCACATATTTGAGGCT CTGTTGTT TGGTGCATACACAAGTGGAATCATTGTGCCCTCTTGGTGGCTTATTTTATGATTATATAGTGCCTATCT TTGTGGTATTTTTATTTGCTCTTAAATCTACTTTGTGTTATATTCATATACCCATTCTTTTTTAAAAAAAA TTGTTTGCGTGATACATCTTTTCATTCTTTAATCTCAGCCTATCTGTGCCATT GAATTTGAAGTGAGT TTTCATATAGAGAACATATTATTGAATCATCATTTTAAAAATTCCTTTTGCCAATCTTTTTTATACTGAGG TAAAATTGACATAAAATTTATCATTTTAAAGTGTACAATACAGTGGCATTTGGTAATACACATGTTATGC AACGTTAACTCTACCTGGCTCCTAAATGTTTTCATCATCCCCAAAAAGGAAACTTCATACTCATTA AGCA encenn / Lznz / B / YiAi GTTAATTCCCATTCCTTCTCTCGGCCACTGGCATCCGCAAACCTACTTTTCTGTCTCTATGAATTTACC TATTATGGATATTTTGTATAAATTGAATTATACAATAAGTGACCTTTATGTTTGGCTTCGTTCGCTTCGC ATACTATTTTTCGATATTCAACCATGTTGTAGTATGTATCAGTTTTATTTGAATAACTCAATTCTTTTTGT TGTATA GCTAAAAGTTGATTCCTAGGTCATAATGATAATTCTATGTTTAGTTTATTGAATAGCTGCCAAA GTTTTTCCACAGTGGCTCTGTCATTTTAAAATCCCACTAGCAATGGATGAGAGTTCCAATATCTCCACA TCCTTACCAATATTGTTATTTATATTTTTATAATTATAATTTTCCTAGTGAATACGCAATGGTATCTCAT TGTGTTTTTGGTTTG CCTTTCCCTAATGACTAATGATGTTGAGCATCTTACAATGTACTTGTTAACTATT TGTGTTCTTTAGAGAAATGTCTATTCAAGTGCCTTGTCCATTTTAAAAAATCGAGTTGTCTTGTTGACTTA TGAGTTCTTTAATACAGTAAACGCTTATCAGATATGATTTATAAGTATTTTAACCCATTCTGAAGGTCAC CTTTTCACTTTTGTGGTAGACC ATTATGCACAAAGGTTTTAATTTTGATAAATCCAATTTATCCGCTTTT GTTGTTGTTTTTGTTGTTCGTGCTTTTGCAAAACCTAGTGTCATGAGGTTTTCTCATTATCTTTGGAGA ATTTTATAGTTTGGGTCTATACATGTAGATTATTGATCTAATTTCCATTAATTTGTGTGTATGCTACGAG GTAGGGGTCCAAATTCAAT TTTTGCATTGAATTGAAAATTCATATTTTCAGTTTCAAATTTCAACTGCAT ATTCAGTTGTTGCAGCACAATTTGTTGAAGAGATCATTCTTTTACCACAGGGAATGATCTGGGACCCTTGTCAAAAATCAATTGATCATAGATGTATGGGATTTCAGACTTTAGATTCTTGTTCCATGAATATGCC TATTTTATGCCAGCACTGCAGTATTTTCATT ACTGTAGCTTTATCATAAATTTTGAAATCAGGAAGTAT GTATCCTCCAAGTGTGATTTTCATTTGCTAGAGTGTTTTGACTATTTGGGGTCTTTGCAATTCCATATG AATTTCAGAATTGGCTTTTCATTTAAAAAAAATGGTAGTTGAGATTTTCATAGGAATTATATTGAATCTAC AGATCACTTTGGGTAGTATTGCCATCTTAACAATATTG TATTCCAATCCATAAACACGGATGTATTGCC ATTCATATCTTTTTTTCTTTTCTTTCGGCAACATTTAGTATATGACACTTGTAACTCCTTGGTTAAATTTA TACCTAAGCATTTTATCCTTTCTGATGCTGTTTAAATGGAATTATTTTATTAATTTCTCTTTTAGATGGCT TGTTGCAGGTGTATAGAAATAGAACTGATTATTGTGCTTTTA TTGAATTATCTGAAACTTTGCTGCATTT ATTAACTCTAGTAGGTTTTTTTTCTTTAAAGTTGTCTATATATCTTGCTCTGTGAATAGATAATTTTAC TTCTTGATCTCCAATATGGATGCCTTTCTTTCTTTTTCTTACCTAATTGCTGTAGCTAGAATTTTCAGTA TAATGTATGATAGAAGTTGTTCACAACTATCCTTGTCTTCTTTCTGATCCTAG GGGTATAGCTTTCAGT CTTTCACCATTAAGCACAATGTTAGCTGTGGGGTTTTCTTAGATGCCATTTAATATATTAAGGAAGTGC TCTGCTATTCTCTAATTGGTTGAGTATTTTTATTATAAAATGGTGTTAGATTTTATGACTTTATGTACTGC ATAATTGAGATTATCATGTGGTCTTTTCATTCGATTAATGTGGTATA TTTTATGATTTTCATATGTTGAT CCACCTTTATATTCTTGGGGCAAATCCCACTGTGTACACGGGTTTTTTAGGGTCTCCTAATTTTCTTCA TTCTTTTTCTTTTCTCTCCCTGAGACTGAATAACGTTAACTGACCTATCTTCAAGTTTACTATTTTTTTCTT CTGCTGTTCAAATCTGCTTGAACCTATAGAGTGAATTTTCATTTTACTTATTGAACTTTTC AGCTCCAA AATTTCTCTTTGGCTACTTTGTATAATATACTCTCTCTCTATAGATATTCTCTATTTGGAAAGACATTTTTC TCCTGGTTTTCTTTACTTATTTGTATTTTTTAAAGTCTTTAAGCATATTTGAGACAGTTGATTTAAGTATT TGTGTACTAAGTCCATTGCCTAAGCTTTTGCATAGAGATTTTATATTAATTTCTTTTTTTTCTGTGAACA GGTC TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAGAAAACTGGACATTTTGAGTAGTATAAACGTGGC TATTTTAGAAATAATTTTCCTCCCTCCTTAGGTTTTGTTTCCACTTGTTGCATGTTGCTGTTGTTTGCTC ATTAGTGACTTTTCTAAAGTATTTTGAAAAGTCTGTGTTCTTGATCATGTGGGTCCATTGAATTCTGTAT T CTGTTAATTTCATAGTCAGCTAGTGTTCTGAAAGTTCCCTTAAGTGCATAGAGCCAATAAAAGAAAAA encenn / Lznz / B / YiAi GAAAAGAAACACAGAAAAAGAAAAGAGGAAAAAAGGAGGGAAAGAGATTTAAAAAAATAATGTCGGTT GGGCATGGTGGCTCATGCCTGTAATCCCAGCACTTTTGGGAGGCCGAGGCAGGCAAATCACTTAAG GTTGACCATCCTGGCCAACACGGAGAAACCTTGTCTCTACTGAAAATATAAAATTAGCCGGGCATGGT G GCACATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGAGGTAGGAGAATCACTTGAACTCGGGAG GTGGAGGTTGCAGTGAACTGAGATCACACCACTGCACTCCAGCCTGGGCAACAAGAATGAAACTCCA TCTCAAAAAAAAATAATAATAATAATGCCTTTGCCGATTTGCTCTGTGTTTGGGCCCTCATTCAATGCC TAGTCAGG CCATTTACAACTCTCTCTTAACTTTCACTACCTGCTTGTGTACTGACTGAAGGCCACCTAT AGGTGAAAGCTTAACATCATCTCAGATCTTTTTGGACCATGAATCCTACCCTGGGTATGCACATGATC TTCTTAATTTCCCAGTAGATGCAAGAGTTTTAGTGTTTTAAAAGTCCTTATTCCCTCATCTATCTTCTTT TCTGACCTTTTTCAGTCTGCT TATTGTTCATCTGAACTGACATCCTTTGCCCCAAGCGGCTGTGGCAA AAACTTTTACCTTTAAATGCTTTCACCACAAGCCACTTGGGAAGCTGCCCCAGACCTGGGACTGCTCT GACCCTGATGAAACAAAGACAAGACCTTGTACAGCCAGGCAGCCATAAGACAAGTCCATACCCAAAC CACAGTTCTTTCAGAATAAGGTCTATATTGGATT CTCTGGCCCTAGTAACCAGCATGAGTCTGGGCTT GCCATCTTCATGGCCACTTGTCTTAGTTTGCTAGGGCTGCCATAACAAAATATGAGAGACTGAGTGGC TTAAACAAGAGAAATTTATTTTTCACAATTCTGAAGACCAGAAGTCCATTACTCTGAAATCTCTCTCCT TGGCTTGCAGATACTGCCTTCTTGCCGTGTCCTCACACA GCCTTTTCTCTGTGTACACATCCCTGGTG TTTTTTAAGCCTGTCCAAATTTTCTGTTCTTCTGAGGACACCAATCAGATTGGATTAGCGACCACCCAT ATGATCATTTTTACCTTAAGTACCTCTTCAAAGGTATCAGAGTAGTATATTTGCTACAGTTGATGAACCTGCATACAACATCATCACTTGAGGTCTGCAGTTTACATTAGAGTTCA TCGTTAGTGTTATATATTCTAGG GTTTGTTTTGTTTTGAGACAGAACAGAGTCTTGCTGTGTTACCCAGGCTGGAGCGCAGTGGTACAATC TCATTGCTACCTCTGCTTCCCAGATTCAAGCAATTTCCATACCTCAGCCTCCTAAGTAGCTGGAACTA CAGGCGCACACCACCATGCCCAGCTAATTTTCGTATTTTTAGTGGAGATGGG GTTTCACCATGTTGG CCAGGCAGGTCTTGAACTCCTTGCCTCAAGTGATCTGCCCGCCTCAGCCTCCCCCAGTGTTGGGATA ACAGGCATGAGTCACCATGCCTGGCCTTATTCTATGGGTTTTGAAATGTATAATGACATGTATCCATC GTTGTAGTATTAGATAGAATAGCTTCATTACCCTAAAAGTCTTCTTTGCACTGGGTT GAGTTTTAAAAG CTCTTTGATTATTTTATGACAGTTCCTTATTAGATATCTTTTGCAAGTATTTTTATCAGTCTGTGGTTA TCTTGTCTTTTACAGAGCAGTAATTTTTAATTTTAATAAAATCCAATTTGTCAATTACTTATCTCATATGA CTCTGGTGTTACATCTAAAATGTTACCACCATACTCAAGGTCACCTAGGTTTTCTCTAGGAATTT TATG GTTTTGCATTTTACATTTGGTGTATGACCCATTTGAAGTTAATTTTTGTGAGGTTGTAAGGTCTGTGCC TAGATTCATTTTTTTTTTTTTTGGCATGTTACTTCAGTATTCATAAGAAACATTGTTCTGTAATCTTCTT CTTATAGTATCTTAGTCTTGCTTTAGTTTTTGGGCAATGCTGGCCTCACTGAATAAATTCAAAG TGTTC CCTCCTCTTCAATTATTTGGAAAAGTTTGAGAAAGACTATTGTTAACTGTTTTCTAAATTTTTTGGTGGAA TTTACCAGTGAACCAACTGGTCCTAGGCTTTTCTCCAGTAGGTGGTTTTGATTATGCTTTCAATCTCTT TACAAGTTACACATCTATACAGACTTTTATAATTCAGTCTTGGTAGGTTGTGCGTATTTAGGAATCT GA CCACTTCATCTAAGTTATCCAATTAGTTGGCATGCAATTATTCGTAGTTCTCTGAATAATCATTTTTATT TCCACAAAATTGGTAATATCCCAGTTTCCATTTTTTTTATTCATTGAATCTTCTTTTTTCTTAGCTAATCTA GCTAAATGTTTGCCAATTTTGTTGATCTTTTGGAAGAACCAACTTTTGATTTATTAATTTTCTCTCTACTCT TTTTCTGTTCTTTATATT ATTTATTTCCACACTAATCTTTACTATTTTCTTCCTTCTGTTGGCCTTTAATTT encenn / Lznz / B / YiAi TTTTTTTTTAATTTTTAAGGTGTAAATTTAGGTTGAGAAATTTTTAAATGAAAGCATTTAGAGCTATAAA TTTTCCTTTCTGGTGTTCCTTTCACTACCTGCCATAAATTTTGATATGTTGAGTTTTTGTTTGTCTTGGAG TATTTCTAATTTGTCTTCTAATTTCTTCCTTGACCTATTGGTTATTTAAATGTATTTAATTTTTGCATATT GTG GATTTCCCAGTTTTCCTTCTGTTATTGATTTCTAGTTTTATTCCATTGTGATCAGAAGATATTTT GTATAATCGCAGTCTATTAACATTTATTAAGTCTTGTGGCCTAACAGAGGATCTATGTTGGAGAATGTT CCAAGTGCAATTGAGAATACTATTCTGGTGCTATTAGGTGAAGTATTCTCTATATGTCTGTTAAGTCCA ATTCATCTATA GTGTTGACGTTTCCTGTTCCTTACTGATTTTCTGACTTATTATTATTATCATTATTAAAAA GTGGAGTGGTAAAGTCTCTATTATTGTAGAACTCTCTGTTTTTCAAGTCTATCAATATCTGTTTCATATA TTTTGGAGCTCTGTTTGCTGCATATGTGTTTACAATTGTTATATCTTCTTGGCAAATTGACCAGTTTCAT CAACATAAATATAATTC TTATTGTCTTCTAACAGTTTATTTTTCTTTTTACATAAAGCTTATTTTATCTG ATCTTAGATTCCCTCACACTCCACCCCAGCACGCTTTTGGTTACATTTACATAATATATTCTTTTCCATC CTTTCATTTTCAACCTGTTTGTGTCTTTAGATCTAAAGTGAATGTCTTACAGACAGCATAAGCTATGTC ATTAAAAAAATCCATTCTGCTTATTCCTGCC TTTTGACTGGGGAGTTTAATCCATTTGCATTTAAAGTAA TCACTGATCATTAAATACTTTCAGTATTTTGTTGTTTTATGTATGTCTTATAACTCTTTTGCTCTTCATTT CCTTCAATATTGCCTTTGTGTTTAGCTTATCTTTTGTGTCACACTTTGATCCCCTTCTCATTTCTTTTTT ATATTTTCTTTGTGGTTACCAGGAGGACAATGTA TCAACTTTTAAAGTTATTACAATTTTATTTTTTTAAA TCTCTCCCATTCGGGGGATTTTAGGAAGGTTAAATAATAATGTAAATGAGATACCTAGAACAATATAAGC ATTCAGGAATTATTAACTCAATTCCAATCCTTCCTCCACCTCCACCTCTTTCTCTGTGAGATTATAGAA AAGATGACAAAAAAGGATGTTTTCTGAGCCCTTTAATTGTTGAGAATGATCTTT GAGAAAAAGAAAAAAA ATGAAAGCACTAGGAATGTACAACAGCCTGGAAGTATAATTAAGTGTAAATTAAATAGATAAAAGTTAT AAGCAGAGGAAAGTATAGTAGAACTCAGTATTTAAAAGAGAATCAATGTGAAAATTATATAAATTTATG TAAAATAAAACTACCAGACAAATCTGATATCCTTAGGATTTTTCTTTCTTTCATGTGATTTCTAATTGCT ACATATGACACTAAACCATTGATCTGAGCTGTAAGAGAAACTGGAAATTGTTCTGTTATTCTTTTGTAAG ATTTCTAGAACATTTTGCCCTCAGACTTAAATGCCAACGTATTTCTCACTTATTGTTTACTGCTTTTGGA TTTACATATGATTTGATTCTTTCTTATCTCTTATCCTTACAATGTAATTCAAACTGATGCCAATTTAAGTT CAATTGCGTACAA AAACTCTACTCCTATGCAGCTCCGCCCCATCTAATTTACATTATTGATGTCGCAAA TTCCATCTTTGTACATAGTTTACATATTAACATGGATTTATACATTTTATGTATTTGGTTTTTAAATCCT GTAGAAAATAAAAAGTCAACACACCAATATTAAAATAATACTGGTTTTTATAATTTGTCCATGTGCTTACC TTTATCAGTGTTCTTTACAT CTTTATACGGGTTTGAGTTACTGTCTTGTGTCCTTTAGTTCCAACCTAAA GAACTCCCTTTAGCATTTTTATAGGGCAGGTCTAGTGGTAATGAACTCTCTGAGTTTTTATTTAGGGAT GTCTTAATTCTAGCTCCTGTTTGAAGTAAATTTTCTGGATATACAATTCTCTGTTGATTGATTTTTGT TCATTTTCCCTTCAGCTCTTTTAAATA CATTATCCCACTTTCTCTGCCTTCCAAGGTTTCTATTAACAA AATTCAGCTTATAATCTTATTAAGATCTCATGTACATGAGTGGCTTCTCTCTTGCTGTTTTCAAGATTC TGTGACTTTGGTTTCTGATAGTTTAAATATAATGTGTCTTATTGTGGGTCTCTTTGGATTTATCCTAGAG TTTCTTGGTCTTCTTACGTTGGTA TATCCATGTATTTCAAGACATTTGAGTAGTTTTCAGCCATTATTTC TTCAAACAATCTCTCCTCTTTGGGGACTTCCATTTTACCTATATTGGTTCTTTTTGATGGTGTGGCACCA GTCCCCTAGACTTTGTTCACTTTTTTCCAGTCTTTTATTTCTGCTTCTCAGACTCAACAGCTTCAAGTG TTCTGTATTCAAGTCTGCTGACTCTTTCTTC TTCCAGCTCAAATCTGCTGTTGGATCCCCCTTGTAAA rncrnn / Lznz / B / YiAi ATTTTTAATTCCATTTTAGTGTTTTTCAAGTTAAGTATTTTTATTAGGTTCCTTTTTATAATTTCTTTTTGT TGATATTCTCATTTTATTACACATAATTTGTCTGATTTCCATTAGTTTTTTTCTTTGTTTTCCTTTAGCTC TTTGAAAATATTTAAGACATTTTAAAAGTCTTTATCCAAGTTCAATTCTATGGTTCTGTAGAGATATTTT CTGCCAGTT TATGTTCTTCTTTTCCATGGGCCATGTTTTCCTGTTTCTTTGTATACTTTCTAATTTTTGG TTGAAAACTGAGCATTTGAAAATAGAGCCAACTTTCCCAGTTTCTGCAGAGAGTCTTTATGCCACAGT ATTCGTTCACTGATTAACTGGGTATATCTAAGCTTAGGGAGCAGCTGAGTCAAAAGTTTAAGGTCTTC TCAGGTCTTTT CTGAGTATACATGTTTCCTATGCCTGTGTGAAATGTTCTCAATTTCCCTATATAAACA GCTACTTCTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTCA TCTCAGCTCACTGCATCCTCCACCTCCCAGGTTCAAACAATTTCCCTATACAGGTGTGTGCCACCACGTCTGGCCAATTT TTGTATTTTTAGTAGAGACAGGGTTTCGCCGTGTTGGCCAGGCTGGTCTCAATCC CTGACCTCAGGAGGATTACAGGCTTGAGCCACAGTGTCCAGCCTAAACAGCTACTTTTGAATGCTTTA ATTTCCTGAATAGTCTCAACCCAGTTTTTCCTTGAGGTCTTAGGTGGTCCATTGTATGTCTCCACCCAT AGTTGCTTG CCCCAGGCATCTGTGGGTCTGTGGTACCACTGCAGCTTTCACCACCTGTAGCTGCCAC CTTTCCCTATCTGAGATCCAGGTTAGGTGAGAGAGATCATTCCTTCACGCAGTCCCATGACAGGTTG GAACATTTCAAATAAGGTCTGTTCTGCTCCTCTGGTTGAAGGGAGAAAATTGGGAACCGGTTTCCCAC CTTTACAAACC AAGATTCTCATGTTGCCACGGGAGTGGCAGGGCAAGTGCAAGTGAAAATGCCATAC AATTTTTCTACCATTTTGAACGCGGGTTTTTCTTCAATGGTCATTTGCTTGGTTGCTGTAGGCCTTTCAC TGTTTTCCAGAGCTCCCATAAGATTACTTTAGCCAGTTTTTTGTTCTTCCTGATGCTTCCCTGGCAGA GTAAGGGTTG GAACTTCCACCATTTTGCTGATTCATAACTCTGTAGTCAGTTTTAAATATATTGATACT TGAGTTTGTTTTATGGCCCAGAATATGGTCTTGGTAAATGTTTCACATATACTCAGAAAGAATGTGTAT TCTGATGTTGTTACATGGGCTGTTCTATAAATGTTACTTAAGGTGGTTAATAATGTTGCTCAAGTCTTC TATATTCTTGCTGATT TTCTTTTATTTATTTATTTTATTTTTTTTATTATACTTTTAAGTTCTAGGGTACAT GTGCACAACATGCAGGTTTGTTATATATGTATACATGTGCCATGTTGGTGTGCTGCATCCATTAACTC ATCATTTACATTAGGTATATCTCCTAATGCTGTCCCTCCCTGCTCCCCCCACCCCATGACAGGCCCCA GTGTGTGATGTTCC CCTTTCCTGTGTCCAAGCGTTCTCATTGTTCAATTCCCACCTATGAGTGAGAAC TTGCGGTGTTTGTTTTTTTGTCCTTGTGATAGTTTGCTGAGAATGATGGTTTCCAGCTTCATCCATGTC CCTACAAAGGACGTGAACTCATCCTTTTTTATGACTGCATAGTATTCCATGGTGTATATGTGCTACATT TTCTTAATCCAG TCTATCATTGATGGACATTTGGGTTGGTTCCAAGTCTTTGCTATTGTGAACAGTGCT GCAATGAACATACGTGTGCATGTGTCTTTATAGCAGCATGATTTATAATCCTTTGAGTATATACTCAGT AATGGGATGGGTGGGTCAAATGGTATTTCTAGTTCTAGATCTTGAGGAATCACCACACTGTCTTCCAC AAT GGTTGAACTAGTTTACAGTCCCACCAACAGTGTAAAAGTGTTCCTATTTCTTCACATCCTCTCCAG CACCTGTTGTTTCCTGACTTTTTAATGATCGCCATTCTAACTGGTGTGAGATGGGATCTCATTGTGGTT TTGATCTGCATTTTCTGATGGCCAGTGATGATGAGCATTTTTTTCATGTGTCTTTGGCTGCATAAAT GT CTTCTTTTGAGAAGTGTCTGTTCATATCCTTTGCCCACTTTTTGATGGGGTTGTTTTGTTCTTGTATATT TGTTTGAGTTCTTTGTAGATTCTGGATATTAGCCCTTTGTCAGATGAGGAGATTGCAAAAATTTTCTCC CATTCTGTAGGTTGGCTGTTCACTCTGATGGTAGTTTCTTTTGCTGTGCAGAAGCTCTTTAGTT TAATG AGACCCCATTTGTCAATTTTGGCTTTTGTTGCCATTGCTTTTGGTGTTTTAGACATGAAGTCCTCGCCC ATGCCTATGTCCTGAATGGTATTGCCTAGGTTTTCTTCTAGGGTTTTTTATGGTTTTAGGTCTAACATT encenn / Lznz / B / YiAi TAAGTCTTTAATCCATTCTTGAATTAATTTTTGTATAAGGTGTAAGGAAGGGATCCAGTTTCAGCTTTTA CATATGGCTAGCCAGTTTTCCCAGCACCATTTATTAAATAGGGAATCCTTTCCCCATTTCTTGTTTTGTCAAAGATCAGATGGTTGTAGATGTGTGGTATTATTTCTGAGGGCTCTGTTCTGTT CCA TTG GTTTATATCTGTTTTG GTACC AGT ACC ATG CTGTTTTGGTTACTGTAG CCTCGTAGTATAGTTT G A AGTCAGGTAGTATGATGCCTCCAGATTTGTCCTTTTGGCTTAGGATTGTCTTGGCAATACAGGCTCTT TTTTGGTTCCATATGAATTTTAAAGTAGTTTTTTCCAATTCTGTGAAGGAAGTC ATTGGTAACTTAATGG GGATGGCATTGAATCTATAAATTACCTTGGGCAGTATGGCCATTTTCACGATACTGATTCTTCCTATCC ATGAGCACGGAATGTTCTTCCATTTGTTTGTGTCCTCTTCTATTTCGTTGAGCAGTGGTTTGTATTTCT GCTTGAAGAGGTCCTTCACGTCCCTTGTAAGTTGGATTCCTAGGTATTTT GTTCTCTTTGACGCAACT GTGAATGGGAGTTCACTCATGATTTGGCTCTCTGTTAGTCTGTTACTGGTGTATAAGAATGCTTGTGA TTTTTGCACATTGATTTTGTATCCTGAGACTTTGCTGAAGTTGCTTATCAGCTTAAGGAGATTTTGGGC TGAGACGATGGGGTTTTCTAAATATACAATCATGTCATCTGCAAACAGGGACAAT TTGACTTCCTCTTT TCCTAATTGAATACCCTTTATTTCTTTCTCCTGCCTGATTGCCCTGGCCAGAACTTCCAACACTATGTT GAATAGGAGCGGTGAGAGAGGGCATTCCTGTCTTGTGCCAGTTTTCAAAGGGAATGCTTCCAGTTTT TGCCCATTCAGTATGACATTGGCTGTGGGGTTTGTCATAAATAGCTCTTATTATTTTGA GATATGTCCCA TCAATACCTAATTTATTGAGAGTTTTTAGCATGAAGGGCTGCTGAATTTTGTCGAAGGCCTTTTCTGCA TCTATTGAGATAAACATATGGTTTTTGTCTTTGGTTCTGTTTATATGATGGATTATGTTTATTGATTTGT GTATGTTGAACCAGCCTTGCAACCCAGGGATGAAGCCCACTTGATCATGGTGG ATAAGCTTTTTGAT GTGCTGCTGGATTCAGTTTGCCAGTATTTTACTGAGGATTTTTGCATCAATGTTCATCAGGGAAATTG GTCTAAAATTCTCTTTTTTTGTTGTGTCTCTG CC AG GCTTTGGTATC AG G ATG ATG CTGGCCTC ATAAA ATGAGTTAGGGAGGATTCTTCCTTTTTTCCTATTTACTGTACATTTATTCCAC CAGTGACTAAAACAGGT GTATCAATAAAATCTGTTCCCTCAGGTTTTGCTTCAGGTATTTTGAGGGTCTGTTATCAGGTGCATAAA CAAGATTGTTATGTCCTATTCTTAAATTAATCTCCTTATAATTATGAAGTTAATTTTTTTTTCTTGAGAT GCAGTTTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCACAATCTCGGCT CAGTGCAACCTCTGCCT CCTGGGTTCAAGCATTCTTTGCCTCAGCCTCCCGAGTAGCTGGGGTTACAGGTACCTGCCACCACG CCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAAGCTGGTCTTGAACT CCTGAACTCTTGATCCACCCACCTTGGCTCCCCAAGGTGCTGGGATTACAG GTGTGAGCCACTGCGC CTGGACCTGGCCCGAAGTAAACTTCTTTACCCTTGCTAATGATCTTTGCTCTGAAGCATGCTTTGCTG GTATTAATATAGTCATTCCTTTCTTTCTTTGATTCATGTTTGCAGGGTATATCTGTTTCCATTCTTTACTT TTAACCTATTGTCTTTATATTTAAAGTGCATTTCTTGTAAGTATAATTG GTTTCTTAAAATCCAATTATCT GCCTTTTAAATGTCATTTTTATGATTTGCATAAATATGATTATTATTACAGCTAAATTGAAATCTGTCA TCTTGCTATTTGGTTTCTATTTATCCCATTTTTTTCCCCTCTTTTTTTGCTTTCCTTGAGATTGAACATTG TATTAGTTTTCTAGGGTTGCTGTAAGAAAGTGACATAAAGTGGATGGCT TAAACAACAGAAATTTATT GTTTCAGTTTGGAGGCTAGTCATCTGAAACCAAGGTGTCATCAGGGCCGTATTCTCTCTGAAACCTGT AGGGAAGAATTCTTTTCCTGCCTGTTCTAGCTTCTAGCATTTTCCAGCAATTCTTGGCATTCCTTTGCTT GTAGATGTATCCCTCCAATCTCTGCCTCTATCATAACATAGCCATCTTCTCCCTTTATCTGTCTATTCTT CT CATCTTATAAGAACATTAATTACTGAATTGGGGCCCAGCATAGATTAGGCCTAATCTCATCTTGAAT AGGTTACATCTGCCAAAGATTCTTCTTCCAAATAAGATCACTTTTACAGCTTTTACAGGTACTGAGAGT encenn / Lznz / B / YiAi TAGAACCTCAATATATCCTTTGGTGGGGACCGACCTCTTACCCATAAAAAGTATTTTATATGATTCCATTTTATCTCCTTTTTAGGTTATTAACTACAATTTTTTTTTCTTTTTTTTGAGATGGAGTTTTGCTCTTGTAGCCCAGGCTGGAGCGCGATTTTGGCTCACTGAAACCTCTGCCTCCCGGGTTCAAGTGATTGTCCTGCC TCAG CCTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCGTGCCTGGCCAATTTTGTATTTTTAGT AGAAACAGGGTTTCACCATGTTGGCTAGGGTGGGTCTCAAATTCCTGACCTTAGGTGATCCACCCAC CTCGGCCTCCCAAAGTGCTGGGGATTACAGGCGAGAGCCACCACGCCTGGCTTTATAATtTTTTTTTAA TTCAGTGGATGTTTTAGGGTTTATAGTATACATCTTTATCACAGTCTAGCTCCAAGTGATATATCCCTT TATGTATAGTACATGACCCTTACAGTAGTGCATTTCCATTTTTCCTCTCTGGCATTTAGGCTATTGCAC ACACATACACTCAATTCATCCCTTTGTGTAGATCCGTATTTCCAGCTGCTATTCTTTTGCTTCTGTCTGA AATA TATGTATGATTTCTTTTATGACTATTTTGAGAAATTTGGTTATGTGCATTTGTCTATTTTTCTTATG TACTTTTAGCTCATCAATCTTAAGTCTGTGAGTTTATAGTTTTTAAAAAACAAATTTGAAATTATTTGGCT ATTATTTCTCAAATATTTTTTTCTGCCGCCCCTGCTTTCCCTTTCCTTAGGGATCTCTGATTTCCACCT ATATTACT CTGATTGAAGTTGTTCCACGTCTCTTTTGAAAATCTCTGAAAAATCTTTTATCATTTGGATA ATCTGTATTTGTACATCTTCAAGTACATTAATATTTTCTTTTTGCAATGTTTAATCTGCTGTTAATCCCAT GTAGTGGATTCTTCATCTCAGGTATTGCTGTTTTAATCTCTAGAAATTCCATTGAAGTCTTACTTGATG AAAAAGGCAGATAAAAACA AATGTTGGCAAAGATATGGAGAAATCAGAATCTGCACACACTGATGATG GGAATGTAAAATGGTCAAGGCAATTTGGAAAGCAGTCTGGCAGTTTCTCAAAAGGCTAAACGTAGTTC CCATATGACAGCAATCATTCATCTAGGTATATACTCCAGAGAAATAAAAACATATCCACACCAGAACTT GAACATTAATTTTCATAGCAACATTA TTCCTAGGGGTTTAAAATTTTTTACATTATTTTTATTTAAAATAG AGACAGGGTCTCACTACGTTGCATAGGCTGGTCTGGAACTCCTGGAATTAAGCATTCCTCCTGCCTTT GTCCTGTTTTCTCCACTGGAAAAGAATAAAACTTTGTACACTTGGACTAACAACTCCCGATTCCCTCCT TTACCAACATGCCCCACAGCCTCTAGTAACTTACTCTCT ACTTTCATGAATTCAACTTTTTTAAGATTCC ACATATAAGTGAGATCATACAATATTTGTCTTTCTGTGCCTGGCTTATTTCTCTTAGCATAATGTCCTC CAGATTCATACATGTTGTCTTAAATGACAGGATTTACCTTCCTTTAAAGGCTGACTAGTACTTCATTGT GTATATGTATCACATTTTCTTTATCCACTTATCTGTTGATGGGCACTTAAA TTGTTTCAATGTCTTGGCT ACTGTAAGTAATGCTTCAATAAACATGGGAATGAAGATATCCCTTCAACATATTGATTTCTGTTCTTTTT GGATAATACTCAGAAGTGAGATTACTGGATCATATGGTTGTTCTATTTTTTCAGAAACCTCCATACTG TTTTTCATAGCGGCTGTACTAATTTACATTCCCACTAACAATGCATGAGTTCACTTTTCTGGA CATCCT CCCCAACACTTGTTATCTTTCATCTTTTTCATAAAAGCCATTATATAATAGGTGTGAAGTGACATTCCA CTGTGGTTTTGATTTGCATTACTCTAATAATTAGTGTGAGCATTTTTTTTTTTCATGTACCGAATGTCT TTTGAGAAAGGTCTCTTCATTCCTTTGCCCATTTTAAAATCAGGTGGTTTTCTTGCTCTTGAGTT GTTT GAGTTCCTTATGTATTTTAGATATTTACCCATTTCCAGATATATCATTTATTTTTCCTATTCTTTGAG TTCCCTCTTCACTGTGTTGTTTCCATTGCTGTGCAGGTCTTTTATTTTGATGCCACCCATTTGTCTAT TTTTGCCATGCTTTTGCAGTCATATCCAAAAAAAATCATTCCCAAGACCAATGCTGTGGAGATTTCCCCC T ATGTTTTCTTCAGTAGGTGTACAGTTTTAGGTCTTATATGTTAAGTTTTAAATCTATTTTTTATATGGT GTAAATAAGGGTCTAATTTAATTCTTTTTGCATGTGGATATCCAGTTTTCCCAACACCATTTATTGAAGA CCCTGTCCTTTTATACTTTTCAGTATGCAGATCTTTTACCTCCTTAAATTTACACCTCAGTATTTAATAT TTGTTGC TATTATGAGATTTTCATAATTTCCTTTTCAGATAGCTCATTAATAGTAGATGGAAACACTACT encenn / ίζηζ / Β / γίΛΐ GATTTCTGTAAGATGATTTTGTATTACGGAACTTTACTGAGTTTGTGTATCAGTTCTACCAGGTTTTAG TTTTGTTCTGGTGGAGACATTACAGTTTTTTGTATATGGTTATGTCATCAGTAATTACAGATGATTTAAC CTATTCCTTTCCTATTAGGATGCCTTTTTTTTCTTTCTCTTGTCCAACTGCTCTGGTTAGGACTTCTAGT ACTATGTCAAAAAGTGATGAGGGTCGTACATGGCCTCCATACCTAATCTGTTGAGAGTTTTTACCATG AAACCAGGTTGAATTTTGTCAAATGCTTTTTCTGCATCCATTGAGATGATCATATGATTTGATTTACAC CCTCCATTTTGTTATGTGGTATATCACACTTTTTGATGTGCATATGTTGAACCACCCTTGCATCCTAAG GATAAA TCCCACTTCATCATGGTGAATCATTCTTTGTATTCGTGAATCCAGTTTGCTAATATATTGTTGA GGATTTTGCATCCATGTTCATCAGGGATATTACTTTGTAAGTTTCTGTCCTTAAAGTGTCTTTCTCTG GCTTTAATAACAGTGTAACACTACCCTTGTAAAATGAATTTAGAAGTATTCCCTCTGCTTCATTGTTTTG GAAAAGTTTGA GAATTTTTATTAGTTCTTTAAATGTCTGGTAAAATTCAGTAGTGAAGCTGCCTAATCC TGGGCTTTCCTTTGGTGGGATACTTTTTATTACTGGCTCAATCTCTTTTCTTGTTATTGGCTTATTCAGA TTTGTTTCTTCATGATTCACTCTTTGTAGGTTGTATATGTCTAGGAATTTATTCATTCTTTAGGTCATC CAATTTGATG GTGCATAACTTCATAGTAGTTTCTTATAATCCTTTGTATTTTGGTGATATCAGTAGTAAA TGTCTCCTCTTCATTTCTGATCTTATTTGAGTACTCTTTTTTTCTCCTAGTCTAGGTAAGAATTTGTTG ATTTTATCTTTCAAAAAAAAAAAAAACCAACTCTTAGCAACTCTTAGTTTTGTTCATTTTTTTCCAGTCTT TATTTCAACTGTGATCTTTG TTACTTACTTCTTTATGCTAACTTTCGGGCTTAGTCTGTTCTTTTCCTAG TTCCTTTAGGTGAAAAGTGAGATTGTGATCCTCTTCTTTATTGGCGTAGGTTTGTATCGCTATAAATT TCCATTAGGACTGATTTTGCTGCATCACATAAGTTTTGTTTCCATTTTCATTTGTTCCAAGGTAATTTTT TATTTACTTTTTGACTTCTTCTGTGAACT ATTAGTTGTTTGGGAGCATATTGTTTAATTTCCACATATTG CTGTATTTTCCACCAGAATTGATTCTTGTTCTTGATTTCTAGTTTCACGCCATTGTAATCAGAAAAGGG ATTTGATATGATTTCTGTCCACTTAAACTTAAGATTAGTTTTGTGGACTAACATATATCCTGGAGAATGT TCCATGGGCATTTGAGAACAAAATGTA TTTTGCTGCTTCTGGATGGAATGTTTCATATATGCCTGTTAA GTCCGTTTGGTCTAAAGTGTAATTGAAATCCATTGTTTCTTTATTGATTTTCTGTCTAGGTGATCAATCT GCCCATGGTGAAAAGTAGAGTATTGAGGTCCCGTATTATAGTATTGCAGCCTATCTCCCTCTTCACAT CATTTAAAAATTGCTTTATGTATTTAG GTGGGTCAATGTTGGGTGCATATACTTTTACAATTGTTATGTC TTCTTGGTGAATTAATCCCTTTATCATTATATAACAAACTTCTTTCTTTTTATAGTATTGACTTAAAGTCT ATTTTGTCTGATAGAAGTATAGCTACCCCTGCTCTCAATTTCATTTATAGAATATCTTTTTCCATCC CTTCACTTTCAGTCTATGTGTATGTTTAG TAGAAAAGTGAATCTCTTGCCGGGCGCAGTGGCTCACTC CTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGCGGGATCACCAGAGGTTGGGAGTTAGAGACCAG CCTGACCAACATGGAGAAAACCTGTCTCTATTAAAAATACAAAATTAGCCAGGCGTGGTTGTGGGCC CTTGTAATCCCAGCTACTCGAGAGGCTGA GGCAGGAGAATTGCTTAAACCCGGGAGGTGGAGGTTG CGGTGAGCTGAGATCATGCCATTGCACTCCAGCCTTGACAATAGCAAAACTCCGTCTCAAAAAAAGA AAAAGAAAAAGAAAAAAAAGTGAGTCTCTTATAGGCAGTATGTGGTTGTGACTTAAAAAAAAAAAAAAA TCCATTCTGTCATTCTATGTCTTTTTTGTTG GAGAATCTAATCCGTTTACATTCAAGGTAACTATTGGTAA GAAACTGCTAGTGTCATTTTGTAATTTGTTTTCTGATTGTTTTGTAGGTCCCTTGTTTCTTTTTTTCCCTA TTGCTACCTTCCTTTGTGGTTTGGTGGTTTTCTGTGGTGGTGTGCTTTGAATCCTTTCTTTTATAGTAT ATGCGATTACCATTGTATTT GCTGTAAGGCTAACTTAAAACATTTTATCCTTAGGCTACTTTAAGCGAT AAAAACTTGCCTTTAGTTGCATACAAAAACTCTACGCTTTCACAACCCCCCCGCCTTTCGTGATTTTGA encenn / ίζηζ / Β / γίΛΐ TGTCAAAGTTTACACTTTTTTAAATTTGTATCTCTTATTGTAGCTACAGTTACAATTACTTCTTGTAGCTA CAACTTATTGTAGCTACAGTTGTTTTTAATAGTTTCATCTTTTAAACCTCCTAATAGGAATAACATTGCT TTACCTGCCACCTTTTACAATACTAGAATTCTGACTATGAATTACTTATACCATTTAGTTTTTTACTTT TATGTTTCTCATTAACT AGCAGTCTTTTATTTAAGCCTAAAGAACTCCCTTTTAGTAATTCCAGTAGAGC AGGCCTAGTAGTGACAAACTCCCTTAGGCATTGTTTATCTGGAAAAGTGTTTATTTCTCCCCTTTGCCAA GTAAAGTATTCTTAATTAACAGCTTTGTTTCCTTCAGCACTTTGAATATACCATCCCACTCTCTACTGG CCTGTAAGGCTTTTGCTGATAAAGCCACT GAATCTGTATTGGGGCTACCTTGAATGTGATGTTTCTTAT CTTTGCTGCTTTCAGTATTCTTTGTCTTTGATTTTGATAACTTGGTTGTGATGTGTCTTGGTGAACTCT TTAGGTTGAATCTGATCGGTGACCTCAGCTTCCTGTTCCTGAATTTTGTCATCTTTTCTCAGATTTGGG AATTTTTCAGCTATTACTTCCTTA AATATGCTTTCTAGGCCTTTTTCTTTCTTTTCTCCTTAAGGACCTC CTATTATGCAAAAGTTAGCTAGCTTGATGTGTCCTGTAATTCTTATAGGCATTCTTTTTGTTTTTGTTT CTCATTGGATAATTTCAATGTCTTACCTTTGAGCTCATTGATTCTTCTGCTTGATCAAGTCTGCTGTT GAAGCGTTCTACTTAGATTTTCAGTTCA GTTACTGTATTCTTTATCTTTAGAATTTCTATTGTTTTTGTTT ATATTTGTTAAACTTCTCATTCTGTTCAGATGTTGTTTTCCAAATTTCATTTTTCTATCCATATTTTCTTG TACTTTGTTGAACTTAAGAGGATTAGTCTAAATTATTTGTCATTTCACAGGTTCTCATTTCTTCTGAGTC TGTTACTGGAGCTTTTCATATCCAATGTACACCAGAAACTTT GCTAATTCCACAGTAAATGTTAGAAATG GGTTTTTATTGATAAAATCAGTGGCTTGCTAATTAGTATGTTAGAAGCTGGCTTGCATTGGTGAAGTTG AGGGTATTCGATATACGTATCCCGGCTAAAATACTTCTAAAGAACCTCTCCAGCTTTGCAAGAATAGA GTATAGGAATCTGAGGAGGCCTTTAACATGGCCCTCAGAAAGGACA CACAGGGCTTGACCTCTAAAC ATATAAACATATACAGAAACGAGGTCAGAACATGTTTTGACTGATGCCAGTAGTAACACAGCAGAGCC TATTGCTGGTCACTGTTACCAATACCTTGTGTAATAAACCTTTCATTTAAATTGAGAGGTTGTAAGCCC CGAAAAAGCAAAGGGCTTACAGTACCTCTTGCCTGAACACTCCTGTGTGT GCTTTCTAAGAAATGCTT TTAAAATAATGCCTGTGGCACAAATTGATTTGACACTGGCTCTCTTTATAAGCTGCTATCAAGGTTGTG GGGAATAGCTAACTCTTACCCACTTTCCCTGACAAATAGGAACCCGTAGTTACCTACCAAAAGTATGT AAAAGCTATATCCGACCAAAGGCCAGTTAGGTCAAACACCTTGAAAGGAGCTCAGTTTA AGGAAAT CAGTGGTGTCACAGTGCCCCACTAGCGTGTAAAAGTTTTCATAGTTTGACTATCGGATGTGCTTAGTT TCACAGCTGAGTCTTACCTTGTGATACTTTTAGAGCAAAAGTCAAATCAAAGATGATTTAAAAAAAACAT TTCAAAGATTCATAAAGAATAAATGCCTCCTCAGGAAGTCTTCTGGAGTTCTGCCCACTTCCCTTAGG T GGCTCTTTACTGTGCCCATCTCATAGCCTGTCTCCTTCCACTTGGTGTATTGCAGAGTAAAGCTCAC TGTTTACAGGGGTGGTAGAAAGTGTGGTCCTTTCCCAGACTCCTTTTTCCCTTCCTCTCTCATTTTTC AGAAGATGTGTTTGATAATAAACGAAACAAAATGACTAACACATTGAGCTGAGCTACATAAGCAGATG TC AGTTTGACGTGAAGAGTTTAAAAGATCTATGCATTATCTGGGGACTCCTCCCCCAGACCTGAAGGA TCAGGTGCTGCCTTCTATGCCACCTGTGCAGACAGCAAAAGAGGAAAACCATACCCACGTTCAGTAT GAACAAAGGGGACATTTGAACTCTGTGTGGACCCCCTCATTGGAAGGGTGTTTCTTCTCCTGCTGCAT CCACAAAG AGCACTCCTTAGCCTTGCCTTTTGTCAGTTCTTCTCTCCAATAAGGCTTGAGCAGAGACAA CCCAGTGCAGTTCAGAGAGACTGAAGTCTGGTGTTCCAGGTCTGAGTCCTAGCTCTAGCTCTCTGTG TAACTTTGGGATGTCCCAAAGTAACTTTTCACAACTTGATAGGTGTTAACTTGAATTTTGGATACAGGT GACTCTTAGCCCA TCCCCTCTCTGTGCTTCAGATATGTCATCACTTGGGCCATATGACCTCTGGACAC encenn / Lznz / B / YiAi CTTTCCTACTTTTCCACAATTTCAGAGCAGCAGAGCAGACTGGAGCTCCTGCTGCCTCTGAGCTTCAGT GAATTATCACTCGTTGGAGGGAAGCTTCAAGCATTTTGTTATCTTTCAAGAGCAAACACAGTGTCTGT CAGCAAGAATATGTAGCAGATGCTAGTGAACAGCAGTGATTAGGGTTGAATGCTGGATTTAAATATGG A GCTTAGGCTGTGAAGGAAGCCTGAAGAACCTAGAGAGCCCCATGAAGCTGCCCTCTGTGAGATCTGAC ACCATTTCCCACTGATGAGCCATGGGTCTAATGGGTAGCACTGATTCCACATACAGTATGTGAGTGCA ATACAGTGAAAGCAAAGAGAATAAAATGATGGCTAACATGATGTTCCAAACTTTAAACAGGAGAAAAA CACACAATTC CATTATGTATAAACCCCACACAGAGATCAGGAGAATAACCTCATTGGAGAATGAATG ACCTGTGTGGGGAATTTAGGGTAGAGTTGAGATTGAAAAAATGGGCCGAAGTCAGGTGGCCAAGGG CCTTAATACCTTGTATACAAGATGTGTAGTCAAGGAAGACCATGCCTTACTTATGCATCAATTCCCTTGGGCCTACAAAGAGCTG CCTAGCCTGGGACTGTTGTAGAGAAAAGCTACAGTGTTCCAATGACACAGGGACTCCTCCATGTATGTATGAGTGCCCAGCTGGCTCTGTAATAAATCTTATTTTTATTTATTAACTTTTC TTGCGCATTGGCTTGATGCATCAGTTGGAAGTCAGAGGCCAAACGAAGTGAACACTGAGCCAAAGGA AGTTCTCAGCCTTTAGGGAG GCAGAATTCACTTTAAACACAATAAACAAATGAACTCACATTATACAG GAGAGAGTCAGAAGATCCCAGTGGCTGGTGTCATCGGGCCATATTTGCCCGAAGTGCCTATTCCTTA TAGGAACCCACTCCCAGGGTTGATGGGCTACATCCTTAGGAGGCTTTATGCCTATGTTCTCCTGACC ACTGGCTCCTCCAGGGCTGGCCTTTTTT AGTCTCTCTGTAGAGGTTCCTGTAGCTGGTTGGATATAG GCTTTCACAGAAGGGTCAGTGCCTTGGGTCTGGTTACAGGACTGTTAATCTTGCTTTGTTAAGAGTAA TGTTATTCCCCATTTCCAAATTCTCCAGGGAGATGGAATGTCAAAGATAGTATGACTGTAGCACCTA AATCCTGGGTTCCAGAAGCAGAGAAGA GAATACACTGAAGCTGTAGAAAGGCCTATTAGTCCATGTC AGAGATTAACTGGATGCGAGGACCATTTCTGGGATGGTGTATACAGAACTGGAGAACTGGATAGGGA GTCAGAAACAAAGAGCTGAAGATGATGCCTTTGAAGTTTCCAACGTGGATAACTAGGTCAACAGAATA TTACTCAAGAAAGTATTAACATAGGATTGAGATGCAGTCAGTA GTAATGGAATTGAAATTTCAAAGTAT ATACCTCATGGATCTCAGGGGGTGTTGAGCTGATCACCTGGGCTAACACTCCTATGACCCTGGGGAA AATCAAATGACCTGGTACTGTAGCCATGGTAGGGGTGTCATCACCCTTAATCCAACTGGGACAGTGCT GTTTGATATTCATCTGGAACTTGGTGCAGACCCACATTTT GCTGGGTTTCACCACAACCAAGGCTTTT TTGATTCTTTTCCTCTTTAACATCAGTACATCACTGCAAAGTTAATCCTCATATAATAGGAGATGAAACT AATTGCTTATAAAAACAAGATTTTTACAACACTAAAATTGTTCAAGCATATGGGCATATTTATAGTTGCA GGCAGTGTTTCAGATGCAGACTGTTCTTGGCTGCAGTGGTTG TTTACAGGCAGCATCTGTTCTGATTA AATATTTGATGATTATCCCCGAATGTTTTAAAGCATAGTACTGGGCTCTGCTGACTGTACAACAAACTG GCATTTTGACCTATAGGGCACTGGGCTAGGAGATACAGTTCTGAGGGAAGTGAAAGATAGTTAACA ACTGCACAACTGACCCTTTATTAGTTGCAATAAAGCAATCCAACCACCCAAC CCACTGTGATGGCTTT CCTACTATTTAAGGTTGGTGGTGTCAAAGAGACACCCTCCTGTACAGTGTGCAGTGAATCAACATCAT TTCCACAAAACCTCCTTCCTGCACAAAGGAATTATCATACTTTGTTACGAAGTAAAATTTTCCTGTATC AGTCACAGGAGTTCACCAGTTAAGATACTGTTAGTTGAAGACTTCTGGGGTGACTTA ATGAAATAGCT CAGCCATCTGGTTTAAAAACTGGATTCTTCTATCCCTCCACAGCTGTCCATGCACCTGCATCATCT CAAGGCTGGTTCTCCCTGGTGGTAGAAAGGCTGACAGTAAAAACTGGAGCCACATGATTCCTTGCTTA GGCAGTGTTTCTTCATACTCTCACATGAGAGCAGGCATGTTCTTTCCCTAGGCTCACAGTA AACACTC TGTCAAATCTCACAGGCCCAAAGTGCTTTTGGTTATCCCCATTCCAAGCCAATCTGTGGCATGGAAGA pncrnn / Lznz / B / YiAi TAGCATTACCCTGACTGCCTTAGACTAATATACCTACTCCACTTCTGGGGCTGGGAATAATTTTGAGG TCAACCATCCAAACTGCATGACAGCCATTCCATGGAAGAGGTATGGCCTAAATCTTTGGGGCAACCT GAATTCATGAAAACTCTCTTAGATTTATGTAACTATTTTTAGAATTCACTTCTGTATCATTTAATTTTACT AATAAAAATA CCACCTTTACCCTAAATGTCAGCCAAGCGTAAGGCTCCGTTGGGACAGAAGGAACTAT CAAAGCTTTGTGTTTTTATACATTAGCAGCATTTGACAAAGAAATAACTCTGAAGGAAGGAGAATAACC AGGCAGAGTCTAGATGCATGGAAAAGAAGTCTTTGAGAAGGCTTCGCAGGCTGAAGGAAAGGGCAG GACTACTTCAGGAATACAACGTTTA AGTAAAAGAGGTTGGGGTCTGTTGATCTTGAGGAGAGATGAG GATGGACTGGAAAATAGGAGTGAGATATAGTAGGAGAGGAAAGGATATGGATGATGTATATACTGTA TGGGTAACCATCAGTCGACCCTAAGAAGATAATAGTTGTTAAATGGTTAGCTATTTAATGAAAGAAAC CTGAACAAGTAATAATCTTGAGTTGCAAAG TGGCTGGAGTCACACAACAGACTAAATTTCTGGTAGAA CAAATCCAGCAGCTTATGTGAAGGTTACCATGTCTGAAGCTGGATAGAAAAGGTCTAACTTCCAACCA AAGTCACAGTTCTTGAGCTCGGTACACAGAGACAGACTGCTAACAGCTGATGTGTCCTCAGCGAGAG TGTCCTCATTTATATCCTCGTTCTCTTCTGCCTCCTTTTT TTGTTTTAAACTTTTGGGAAGTCTCATCAT TCAATACAGTTCTAATATATCACAATAACAGAGGCGGCCCAATTCTACAAATTGACTAATTCTATCCC TGAAAAGTTCATACAATAAAACTATACAAAGCATCATTTTCAACCATCCTATAGAAAAATTTCCCTATTA AATTTTAACTCTAATCCTCTATCTCTGTTAATAACCTTACTAAAAACTTCCCCATCACTGCCTG CCAG GGAGATCAAAAGAAACCAAATTTAAGAAACCTCCAACACCTGTACCTGACTGAAAAGCAAACATACAG ACCTTTCAGTCCTGCCCCTACTATTCAGCTCCTATCACAGAGACATGGTGGATGTCCCCTTGGGAAG CGGATAGCTCTTAGGTGGAAGCTAGGCCTGCAATAAGCAGGCCAGGAAACATGTCTCCCAGGCCCC ATACTCTG GCAGAAGCACTTGGCCACCAGACAGCATGTCCTGTCAACCTACGAGTTCTTAAAAACA AACACTGGGACCCAGAATAGTACCCTGTGGTCATAGTGCCCACAGTTCACTAAGCACCCTCACAGGT CTTTGACAGAACACTGACTGCCAGGTCACCTGGTGGGCAGAGAAATGGAAGATTCCCAGGCCCAACT AGCATCTCAGGGAAGA ACCACAAGCAGAGCAACTTTCAGAGCTGGTCGGCCAGCGTTGGCACCCAG GGAAGCAAGTGCTATTCCATATTTGGAGAGAACATAAAACTCAAGGAAACAGAGAAGTCCTACTCAAT ACCGTTCTCAACTGAAAACAAGAGAACTTGCAAAAAAGAAACCCAGTTTTCTGGAGTCCATGGAGAAA TATGAAGCCAATGCTCGGCTAACAGAGCAGAAAGCCTTTT ATAAATAATGCCAGTCAAAGCTCCAAAG GTCAGAGCTGATGCATGCCGGATTGTTCTGACAATTCTTAGGTTTCTAGGCAACAAGGAGCTGGTC AAACAGCTCACCTCCAAGGACATACTTTATAATACCACCCTGGTAGACGAGAGCGAGGCAGCAGTGA AGGCAATAGTCAAGAACAGGAGAGGGAGGTAAAGAACAAGATGCTCTTCAGAC AGTCTGGACAAAGA CAGTCCCTACCCAGCTCTCAGGAGTTGCCTCCTTAAGAAGGTGGAGGCCCAGGCAGCTCCCAGGGT GACCCTAAAGACAGACTCCAAGGAAAAGGGTGTGAGGGCAATGGTGAATATAAGGAGGTCCCCTTTC AGTAGGCAGAGCAAGTCAGTTCAGGTCTTATTTTTAGAGTCTCTGAACAGTGAA GAGAAGCTTTCTGT GGACAGCATTCCACCACCATGGGAGGGGAAAGGTGCCATGAGAGACTTCTCCAGTGGGGCATACAA GCATTGTGCAGTGATCCCCAAGATCCAGCCACTGGCAGGAAATCGAAAGGCAAGCTTCTTAAATACA TAGTATATGGAGACAGAAGTGTGGAGCACTCCCAAAATGAAAGGCCAAGACCCAGGAAC AACCTCCA CAACCTGGAGTATATACAAATGAACCCAGCCCTGCTGACTCAGATCCACACCATCCTAAAGCAGGGG TTTCTCATGAATGAAAGGGCTAAGTATTTGGTGGAGAGAATGAGAAGTCTCCCACTGCCCACACATTT TTTCTTCAGAGATTTCTTTTCCAAGAGCCCCTTGAATAAAGGAAGGGAGGGAGCACTGAATGCCCCA on / Lznz / B / YiAi GAAATCAGAATGCATGGTGCGGGAAGACGACAGGAAATAGTTCTCAAAGAGATCAGAAAATAAATTG GAAGCAATTTCATTACCACAAAGAACAGACATTTTTTCTAAGGCACCCCTCCCCTTTCCACCCAATTGT CATTCAGCAACTACTGAATACTTACCAATGAAAAACGTTACCCCTGACCTCAAGGCTGCTCCTGAGCT CTGGTAGAAAATGCT TTCCTTGTCTATAAAACATGGCAAGCAAGGCAGGATTTAACAGTAAGGGCACA GTAGCACTGCAAGCCTTCAAATGGAAACCTGGAGACAAGCAGTGAGAACAGGAAGCAAAAGCAGGG CAGGTGAAGCTAGGACCAGGGCATCTGGAACTTTCCACACAGGTTGGATCTCCATGCCAGACAACAG TTTTCAAGGAAAAATATCTAAGAGGAACAT GACTTTGGGAAACTTTTTGGCAGTACTGCTTACTGTATA CTAGAGAGTAAAAGAATTTGGGGAACATTCACCAATTTGCTTCTTCAGGGGCTTGGGTAGGGAACGT GAACAGGAACCTGGCTCTAATTTCTGAACTTTTTTATCAGTAAAAACAATCCAACAAACGAAAAGCTAGT CAGTGAGAGAACTGGGAGGGTCTGCCCTCCTT CCCTGAGTCAAGCCTTCTGGGGGGACCTCCTGAC ATTTAATTAAGCAAAGACAACGCCCACTGAAGGAAGCTGACCTGAAAGTGACACGCTACTGTGAAAT GAGCATGAAGTGGGAGCTTGTTACATATATGAAATGGCCAGCGATCCTGAGCAAAGCGCTTCAGAGC TTGAGACCTAAGTCTTCTCATCTATATACTGAGGGCTGGACA AGATGATCTGTCAAGCCATTTTATCC CTAATCCACCAAAATCCAATGCTTTAGTTTATTGTCACAAAAAGCAGGTATCGAATGGCTATCCTGCAGT GCCTCCAATCAACATTCAGACTTTTTCCCTGAGGCAATATAAGATAACAGTTAACATGTTTTTATCAAT TAGGTGGTCATGAGATAAATATATATGGGAAGTGGTAGTTTTTCACTTAA ATGCATATAATAATGGTAC AGCTCTCTTTGAATAGTATTTGTTTATTTCTTAAATATTTAAGTTCCTAAAGACGGTAAGAATAACCCAA GGAAGTGAAATCAATGTCACAAAGCACATGGCTAAATAACTGCAGGTTTGCAGTGCCATGTGTGAGA TCAGATGACAGAAGGGAGAACTACCTTTAGGCAGAGGCTTCTCATGTCCCCTGGAGT GGCCATGTGC TGTTCTACATGACTACTTCCACTTCGGTTATGTAGAAGCTATTTAAAGCACACAGATGTTTGTGATGAG AAAAAAGCCACCCTTAATTGAATAATGGAAATTATAAGCATGATTTGAGGGTGGGGGTGGAGGTGGG AGTAGAGATGGGTAGAAAGGAGTGCAATGGAAAACAAAGGAGCCTTCATAAA ATTCAAGTCACTTCTTA GGATAACGTGATTGATTTACTCACCACCTTCTTAGGAACATAAAGCAAACAAGTGGGTTTTCCTTTTAC TGCTTTCTGAAATGAGCTACACTCAAGAAAGCAGCACGGGGGTTGTGCTGTCCCTGCACAGTGGCA GGAGAGTATGAGGAGCAGGTGAATGCCACAACAGCTCCATCCAAGATCATTTTTC ACATGCAGGAAC CATTCTTATACTACCCTTTACTGGTAATTTCTGTAGAAATCTGGAAGTCTGGTTGACACCCTCCTGTAC AGTGTGCAGTGAATCAACATCATTTCCCTTGGACTTTGCAATCACGGTGGCATTCATACATTCATTCAA CAAGTATGTATGTACAGGACAGTGGAGTAAAGAAAACAGATAGTTCTTACTCTCACGAG GCTTAAAAT TTCAGGAGGGAACTAGGCAGTCATGAAGTAAACATAAAAACACAGATTGTAATAGGCACTAGAGAATA ATGAAGACTTTGGGGAACACAATTTAAATTGGAAAAATATCTCAGTTCCGTTAACACATGTTGAAGGG GAATAGCATTGTTTTGCTGGATTTGGGGCCTGGATGCAAGCATGTTGGGTATGCATTGTAG GGTAAT GCATTTCCTTCCATTTGGGCCCAAGTGTATATTTACCACCCAGTTGTGATGAGCTGGGATCCTCCTGC TCAATCTCAGCTTGAAGCACTTGGAGGTTATCTGCCTGCTGTGGGTGATTATTTTGGAGCAAGGTACT TCATTTGCCTCAAGAAACAGATTTGATACCACTACTGTGCCCTTTTGGAACAGAGAAG TAGGCAAGAC CCCAGTGTGAGGCAGAGTGATGGGATCTTTAGGGACATAATTGATGATGTAACTGATGATGATTTTGG AGTTTATACATTTCCAAAGTTTCAAAATATTTTCACTTGGTTGATTTATCTTATGGTGATGACACTACG TAGATATATGCCCTTCTTAAAAGTTACAGTAAGAGGCTGGGAGCGGTGGCTCA CGCCTATAATCCCA GCACTTTGGAAGGCCGAGGTGGGCAGATCATGAGGTCAGGAGATTGAGACCATTCTGGCTAACACG encenn / Lznz / B / YiAi GTGAAACTCCGTCTCTACTAAAAATACAAAAAAATTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCC CAGCTACTCAGGAAGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCT GAGATTCCGCCACTGCACTCCAGCCAGGGCAATGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAA AAAGTTACAGTGAGAGTTGACATTGAGAAAAGGGAGGCCCAGCCAGGGTTATGCAAAGAC ACAGTAGGGAGGAGGATGGGAAGTTTCTGAGACACCCCAGTAACTGCATGGGTCCACAAAGCACAT GTACAGTCTGCTCTATGCACTGCAGGTACAGCCACGAATAAGACAAAGTCTCTGCCCTCATGGAGCT TGGTGTCTGTC TACTGGAGCAGACAAAAAACAAACCTGCTTTTTCTCATTTGCCTCTACTGTGGGTTCC GTGTATAACTCTCAAATGCTAGCATTTCCATGCATTCCATCCTTGTCCTTCTCTCTCCTCTGCCTTTTC CAGGAGAATTTTCCTAGCCACAGGTTCAGCTATGGTCTATGTGCTGGAGTCATACATTTTTATCTTCT GTGTACGTTTTTCTCTAGACCC ATATTTTTAATTGCCTTAGGACAGCTCTCCCTGGATATCCCTCAGAC ACAACTAAAACATCATTCAATTGTACTATTAATAATTTTCCCTTCAAAATCCACTCCTCTTCTCTATAGA CCTAACAGCAACACTGTCCGTCCAGCTCTCAAAACCTGAAATGTGGGAGTTGTCTTTGACTCTTATCT TTCCCATGCATGAGCACTGAATCAATCAGAGTCCCTAGCATG TCTTGGACTGTGGCCTCCCCTTCTATC TTCAGATTATCTGCCTTTTTAGAATTATGGCAATAACTTAACTGCAAAGACCACATGTGCACTTGTGCT CTTTCAGTTTGTAATAAATATAAAATGAAAAGTGATTATGTCTTTGCTTAACGTCTGCAAAATAAAAGTC CAAAGTCCTTGGTATGGTCTATAAGGCCCTCATTATCTGACCTGC CTGCCTTCCCAATCTCATCTTAAT CCCTTACAGCCTGACACTCAGACATACTAGACTTTCCACCTAACTCACTCACATACACCTATCCTGTAT GTCAAGATTCGGCTTGACCTTCATCACCTACCTATCTGCAGTATTTTGGATCTGAATTCTCTGCCCAC ATTGTACTTTCACATACTTCTTTTACCCTTAGTGGTTTGTACTTATGCCTGGTCTA ACTAGATTGTCTCC CTGTAACAGACTTCTTGATTCAACAAAGCAGCTCTGAATCAGCCTGAAACCTATGGCACACTGCAAAA TGGCAAACATTCAATAGGTATTTGCCCAGTAAATGTTAATGAAAGGAAAAAATTCAAACTTCAGTTGG AATAGGATTAGAGACAAGTTAAAAAAAGTTTCCCATAGAAATCTTCCTCATCGTAAATATCATCATC C TAAATGTCCCGAGTCTTTCCATGGGTCTAATTTACCCAAATCATGAAGACTCTCTTTTCTCACTGTGTATG TGTAGTGGGAGAGGCAGAGACAGAACGGTTTTTTTTTTTTTTTTGCAAGTCTGCTCTCTGGATTCGTTTT TCTGGGGATGAAATCTCAGGCTATGTAGCTTTTTCTGGTCCCTTTTTGGTAATCAACAAATCATCAG TTT CTCTAGGTATTAAAAAGCCTACACTTTTGAAACACCAAGAGGCCAAACTCTCTCTTAATTGAAAACATA ATTCTGCCTCTTACTGAGGTCTTTGGGTGGGAAGCTTAAAGACAGCAGTGTTGGGGCAATTGGTTTTCTTTTTCCTCCCTCCACCTTCTTTCCCCATTCAAGAGCTGTTGCTGCCCTTTCTGGAGGGGAGGGAATTA GAAAAAAGATCCTGCCTTACCCAGTCACTGTTAATTATTACTTTGAGCCAGGGTGGGGAATGACTTT CTTTCCTGGAATACACCCTGCTGGAAACCACAGCTGAGATTCTCTAAGCTGGCAGCTTCCAACCTTCC CTCCCTCAACAGCTTCAACATTATATGGCACTCAGCTGCAGGGTGCCTGGCTCCAGGCCGGCAGTCC ATTT GTGCAGGGTAGTTTTCAAGATGGCTCATAGCCCATCCTTTTCAGTGACCAGCGTGGCCTATGG GAAACATACATCTTGACTCCATTATTGGTAGGAGTACTCTTTAGTTAACTGCCACAGGCCAGTTCAGA CACGTCTTACCCTGAGAGCCTTTTCAGAGTCAGGTACCATCCCTGTGTCCCCCAGCATCTGAAGATC ACAGGTGAAGGTC TCCAAGTAGTTCACTTAAAAAATACCTCAGTAGGTTTAAGAACAGGGAAAGCTCC CAATTCATTCTGTCAGGAGTATGACTCTCATCCCCCAAACTGGACAGATATATAATATGAAAACTACAGA CCAATATTCCTTATGAATATAGATGCAAACATTCTAACAAAATACTAGCAAACCAAATCCAGCAGCAT AGAACAAGGTTTATGTAGCATGGACAACTGAGA TTATCCCAGGAATGCAAAGTTAATTCAATATACAA pncrnn / Lznz / B / YiAi AAGTCCATTAATACAACATATTAATAAAGGACAAAACAACATGAAAATCTTGATACAGAAGAAGCATTT AACAAAACCCACAGCCCCTCCTTTTTTTTTTTTTTTGATTAAAAAACACTCAGTAAACTAGGTTTAATAAAA GAATTTCCTCAACTTGAAGCAAACCCACAGCTAGCTAACATCATACTCAATGGTGAAAGACTGAATGC TTTCCCCTTAAATCAGGAAC AAGAAAAAAGATGTCTGCTCTTGTCACTTCTATCCAATATTGTACTGGA GGTGCTAGCCAGCACACTAAGGCAAGAAAATGAAATAATAGGAATCTAGACTGGAAAGGAAGAAGTA AAAGTATTTCTGTTCACAGATGCATGATCTCATATGCAAAAAATACTAAGTGACAAAAAAAGAATTTTA GAAAAGCTACAATATACAAAATCAATATACAAAAAT TAATTTTATTTCTAACACCAGTGATGAATACAAA AATAAAAATTAGAAAATAATCATATAATTAAAGTGGCATCAGTAAAATACTTAGAAAAAAAATTAAAGACG TCAAGACTTGCACACTGAAATCTCTAAAACATCACTGAAATAAAGACCTAAGCAAATGCAAAGACATC CCACAGTCATGGAACAGAAAACCTAACACCATTAAAATAGCAGTTATTCTCAAATTTATC TACCAATT CAACTAAATCCCTATCAAAGATCCCAGCTGTTTTGCAGGAATTGACACAATGATCATATAAAAATTCATA TGCAATGCAAGGGACCCAAAACAGACAAAATGATTTTGGGGAAAAAAAAAAAAAAAATGGAGGACTTG CACATCCCAAATCTAAACTTACTACCAAGCTACAGCCATCAAGACAGTGCGGTGCTGGTATAACGACA GACATATAGG GCAATGGAGTAAGACTGAGAATCCAGAAAGTCTTATATTTATGGTCAACTGTTCTTTG ACAAGGGTACCAGGACCATTCATGGGGAAATAATAGTCTTTTCAACAACTGGTGCTTGGGCAGATGG ATATACAGATACCAATGCACTTATGCAAAAAATGGATGAAATAGGAAACTTCACTACATTCTACTGCAT GCTCGGTCATTTTTCAATC ATTTAGGTGGCAACACTGACAAGATAACAGAAAGATGGAGGTAATAACAT GTGAAAGGCAAAATGGTTTGTTTTTTTTTTTAAAAATGACAGTCTCTATCATGAATTTACTTACACTCCA GGCAAAGGTTATTAGAAGAAAAAAAGATGTAAGAAAATTCCTTAACTGAAATGTGGAAAGAGTATCAA GAGGAGACCCTAAGACACTCTGTAAGAATCCCAG TGACTCCTCACTGTTCAACTAAGAAATGTACCCC ATTATGCTGTGCTACCACGGAAGCATTGGAGGCACTTTGGGGGTTGATGAAGTCTTCATGGATGAGG TACTTTAAATATCTGGTCATGAAGAGTATTTGAGAAATATGACAAGTGAAGATGCTGGGTAGGAATGC AGCGAGGAAAGTGTGTAACACAAGGCCAAATTG GAAAGGTCAGTGAGGGGGCAATCTGTGGAGGCA CTGAATGCAGAGGATATTAAAATTAGCAAGATAGTGTTCTAGCACAATGAAAAGGATTGGAAGAGGGAGATGAGAGTCAGGGAGTGAAATTAGGCAGCTGCTAAGAATGTCCGGGTGAGTCAGAGGATCAGGAC CTGTAAGGGCAGTATAAAGAAGGAAGGAATGATGG GAGAGGTTTAGGGGGAAAGAAGTGACAACCT GTGACAATTGAGGAATGAGAGATTTTGATGATTGGGGTGAAGGTTACATTCTTAAAAAGAAACAAAG AATGGTCGGTCGATAGAGATGCAAGATGAAGAATTTTGTTTTTAGGACTACTGACTATGAGGTAACAA AGAAATCCCAGAGACAGAGGTCTGAGCAAAAGATATGGGATTGG GGAAGAATCTTTGGGAGTGACTG AGGTTGACTAGAGGGAACTGGGCAAGAACAGGTAAGGACTTTAAGCAGAATTGGAGGAGTATCCATC TAAAATCTGGGTAAACTGGGATGGAAAAACAAGTAGCCAGAGAAGCAACAGCCCAAGCTAGGGTGTT GTCAAGGTTATAGATGTTACTGATTTTGGCAATGAGGAGATTATAAGGATC CTTGAAGACTGTACTTTC GGTGAAACTACCATGCATTAGTAGCCTTTCACAGTGATATCTACCCCACACCTGCATCAAAATCTTGC AGTGCCTATTAATAAATGCCAACCCACTAACGGGGAGGGGAGAAAAGACTTGGGACTCTGTACTTGT AAAACCCTCTACCCTCCCCAGGCAATTCTTTACACACTAACACTGTTGAGGTAAAAGGA GACAAGTGA GGGAGCAAATGGAAGGTGTGTTTTTGGATTATACAGTGGCTCATGGAAGGGTGGGAGGGGTACAGA TGGCCCTTAGACACTGGCGGAAAGTCAGAAAAAAAAATTACAGTAAGCAGGTAAAGGGATCAAGAC TACACAGGGACTAGTCTTGGGACGACATTTCTTCCTCTGACAGTTTGTATGGAATTC TTGAGAAAAAT encenn / Lznz / B / YiAi TCCTCGAAGGGGCCTGAAATCTCAGAATGGTCATGTTTTTAATGGGAATAGGGAGTGATGCTGCCCC ATTACAACCATCTGTTCTAACAGAATGTCTGTACCGAGGAGGGATGAGTAACATCGGCAAGTTCTGTT CGAAGCCTTTTTCAAGTTTCTTTTTTGATATGTATCTATCTATCTATCATCTCCCTATACAAGCAAGCATC CCCAAA AGTAGTTGTCTCAGGAAACCAGGGTTAGGATGACCAGCTCATTTGCTGGAGCTGCCAAGGT CCAGAAAAGTTTGGCTGCAGGCTGTTTTCATGTTTTATGTATGTTTGAAATGTTCTATAATAATAAAAG GTTAAAAAAGTTTACATTTATTTGGAAAACCAGTTACTTTAGTTTATGGTTCCTTTTTTTCCCTCCAGAG CTTCCTGGAGA TTGAGGTCTAATTCAAAGAAAACCAAAATATATAATAGAGTACCTGGGCAAAAAAAAG TACTTTTATAACATAACATTTGGGGTAGAGGAAGTATCCACTGTAGTCAAAATGTCTATGTTTTGCTCT TCCTTATTGTTCAGGGACATTCCATTAAATAGTAATGAAAAGGCAGCAAAAGTAAGAGGAGTGACAAC ATGCCCGGCATAATTAAGCA AGCTAGAGCAGCTATTCTGTGCAACCGACGATTTTTTTTCTCTAAAATT TTAAGGGTAGGTTCATTCTGACTCTGTTAAAAAGTCTACTTGATGTGAACAACTCTATATCTGATAACCTATTTCAATTACCACTTTAAAACTTGTCATATGGATACGTTATTACATTGTAGAACTTTAATAAATACCA TAATAATAAAACTTGAGAACTGAAGAGCACACATTTC TTCACGAATTTATTATAAAACGCCCTCAGA GTATTTAATTCTCTCCTCACTTTAATTACACATTAAGAAGCACAGTGGATGAGAAGCCTTTAAGATGACT ACAGTTGCACGAAGGTCCCTTTCATCAAGGTAGCGTATGTACCCTAACAGTGTTCTAAAGGCTGGCC CAGAAAAACCCCATGTTACCTTATCACAATATGGAAAGCATTGTCTTCTTTTTCC ACTAAATTAAATTAT GGTGAAAAGTGCCACAGTTTTATTAGCATTATGGTACATAACAAACAGTTCTGTCTCAATTATGAAAA AAATTAATTAAATAATCCTGAAAGACATCCTTTTTCTCCCCCCAATGATTTGAAAGCTGCATTTTTCCT GCCAATTTCAAACAAACAAATCATCAGGTTGATCTACAGTAATCAGTTAAAACAATCAGTCAATCAATC AAT CAATCACCAAGGCACAAGCTCAGCACATTAGCTATAGCTTGTAGCAAAAGGATATATCAATGTCT CACCTTAGTTAAAAATACATAATCCTTTTATTTTATAATGCAATAAAAGAAATTAACAACATCACATACA CAGAAGACTAGGAAAGGGGAAACTACTTACTTCTGGAAATCAGTAATGTAAACCTACTTGTACTTTTC CATAGTACATGAAAGTAACGTTTAAC ATGTTTTGAATTAATTAATTAAATTTAATCTGTGGGGCTATACA ATGTAATTCTTAGGAGTAATAGTTTCATTCATTTCCAGGTCAGCTTACTGTATGATTAAGTAACACAAG GCACAGTAGCCATCTTTTTCATTATGTTGCAACACTGATCACGTGCCTCGATAAAATGGCTGATTCAA CAAGATGATGGCAACACGAAGGGGAGACTTTGGA TTGTCTATTTAAAATCTAGGTAATAAGTAAGTAA TTAATAAAAACTCTATCTTAAGTGCACTTTCACATGCTTTTTGTTTATAATAAACAAACAACAAACTTCC TAACTTTGTTGCAATAGGCTTGACTACCATTTCATTTGGCCAAATGCACTTTCCCCAGTAAACTTAAAA CAACAACGAGAACACAAGAACAAAAATCCCTGTCCTTTTCATATACTAAGAAAGAG GATTGGCTACTG AAACAGTTCATTGCAAGACACATGAAGACGACATACTGTGGCATGAGTTGTTTTTGTTTTTAATTTGTT GTGCTGTTACTAAAGTTCTGAGGGCTGCAGTTAAAACATTCCAATTCTCCCTTCCTTCCATCTTTCTT TATTGATTGATTCTCAAGATTTTGCACAGAAAACTCTTTGGGGGCTAGAACAGCAGTAATTG CATCAC ACTGTTTTCAAGACTTCAAGTTTCAAAAGCAAATCATTAAAAAAAATACAGTTCCTGATTTGAGTTAGAT ACAGGGACAAAAAAGTAGCACATACTTGAAGGTTACGTGGTCTACAAATGGTGGCAATATTTTCCTTG GGAGAGTAGTTCTGTTGGTATATATTTTTTAAATACTCAAAAGGCTCAACCTCAAGCAGTAATAAACAC AAGCA AAAGTGATTTAACCCTTAAAATAAATATTCAGAAAAACCTCTCTGTACATACAAGTGAAAGAAT ATGTAACACTTTCACGCAAAAAAATAATTATAATAATAATAAAGGATTTGTTCATATATGTAGCTGAAAT CTGCTGTTCCAGCCCACATGTCCCCAATAAAGAAGGGAGGCACAGACATAGGTGACTACTGTGGTTG encenn / Lznz / B / YiAi ACTATCTTACAGCCTTTTTGTACTGGGACACTATCACCACCAAAAAATTTATCCCTCGTTATATTTTTAAA ATTTTTTAAATTTTTTCTTTTTTTTTCCTTCCTTTTTTTTGTTTTATTTTGTTTTGTTTTGTTTTACAGCATG CCAAATCCTTTGGCATACGTGATGGCCTTCAACAATCTCTCTTTAAGTTTTTCCTTTGCTTGAGTATTCC GGAAGTA AAAGCACATTAAAGCAAGTATGAGATGTAGGTAACCTAAATAGAGAAAAGGGGAAAAAAC AGGAAAACTGTAAGTCATGGGAAATACACTTAGAATTAAATGCTCCTATTTTTAGATTGTATATAGTTGAGACGGTCTGCAATGCAAACTATACATTAATGCAAATCATAAACTTTTTGTTGTGTAACTACCAAGTTG CCTTTTATCCTATAAATTACTCAA AGCTAGTGACGATGATAAGATACTGTATCCATTGAGTTTTTACTACA TAACAGATACCATTTAGGTACTGAATTCTTACAGTTCATTTAACTAAATCTTTCCACAACAAAACCACA GAGAGGACATCAGTAAATGCACTTTAGAGGTTAGGTCACTGAGAAGTCAAGTAACTTCCTCTAAGGTG GAGAAAATACTCAAACCTGTTTTACAAGACTGCAAAGTGT GTGCTCTTAAATGCTTATTAGAAACACTG CTGGCAATATGACTAAGAAAATGATTTGATAACAGGATTCTAGCACAATCAAATGATAATCTTCCGAGC CTCAATGTAACCATTCTAAATAGATGATCATGTTATATGGCTTTCAATTAACAAGCTGGGAATCAAAAA AGTAAATGAATCACACTAATTTGATTCCAAACCAATGTGAGCCCCATAATAA TTTTTAACTAGGGCAAT TTCTTAAAAGTTTCCTCACACAATGACAGCAAAGTATTTTCTCAATTGTCTAATATGATTTGGGGATTTG TATATAAAATCACGAATGTGCTCAGAAACTATAAAGACAGTTCATATGTATGTGACGAGGAATGCAAG GTTTTCGGTAGGTATACAGTCACAAGTTAATAATTACCTACCTTTCTGTGTCTGG GCCATTTTTGGCTA TAATCATCTTTAATTTTCCTAGTCCTCCCACAGGTGCTCTGTCTGTGCCCGTTGTAAACTGCAAGAAG AGTCTTTTCTGTTCATCTGTAAATGAATGAACGATTTCCCAGAACTCCCTAATGAGAAAAAATACAATA CTGGTTTCAGTTTGGCATTCATTATGACTGGTACTAACATAAGCTTATGATTTGCATTA AAACTATATTA AGAGACAACTTGGAAGTTAATTATCAGGATAGTATCACTTCTGGTGATTTAAAAATTTCCAAGCAAATT TATCCTGAACAGCTCTGAATACGTAAAAATTTAGATTAGATTACAATATAGTAAAATATTAGTACTACAA TAGTAAAAAATTGAGAAAACCCAAGTGTGTAGTAACAGGAAGTGACTATTTAAACTATGGTATAATCAC ATTATGCA GTCAGTAATGAGCAAAAGACAAAAATCCTATGAATTGAAAAAGACTGAAATGAATATTTGGA AAAATTAACTCCAGGTGCCTTTGGGTATATATTTTATTTATCTTTCTCTCCTTTATTCTCCTGGTCTACTC ATCCTTTAACTCAACTTTGGGAGGAAAAAGTGATACAGATTAAGGACAAAGAAAAAAAGACCCCCTG CCCCAACCAACTGGCCCCAAAT GCAAACAACTACATACCTAATAGCAGTAATACAAAAGTTCAATTTTT ATATGAACTAGAATACTTTAACAAGTAATATGTGCTGTGTATGGAGGAGGAGAATTATTCTGACATTT CTGCCACCTGCAGTTATTTTAAGAGAATGATTTATCCTGTGGCATTCCTAAAATCTATGTAATAAAAGC TATGTTTTAATGACACTTATGTTAGTTTGAG TTCTAAAAAACGAAATACAAGCTCATAAAGTGCAATCTT GAAGTTTATTTGAATAATCAGGCATCTATAAAACATATATACACTAGTTCATAGCTAAATAAATTTTTTTT TTTTTGAGACAGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCATTGCA AGCTCCGCCTCCTGGGTTCGCGCCATTGTCCTGCCTC AGCCTCCCAAGTGGCTGGGACTATAGGTG CCTGCCACCACGCCTGGCTAATTTTCTGTACGTTTAAGTAGAGGCAGGATTTCACCATGTTAGCCAG GATGGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTGCAG GCATGAGCCACCGCGCCTGGCCTATAGCTAAATAATGTTAAG ATTAAAAAATTAAAAAAAAAATTAAAA GTATTTTAGTTGCTTATATAATATAAAATGCATTTTAATAGTTATTTAGAAAGTTCTTTCCAGAGCCAG GTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCCAGTGGATCACCTGAGGTC AGGGGTTCAAGATCAGCCTGAACCAACGTGGTGAAACCCTGTCTCTA CTAAAATACAAAAATTAGCCG rncrnn / Lznz / B / YiAi GGCGTGGTGGCAGATGCCTGTAATCTCAGCTACTTGGGAGGCCAAGGCAGAAGAATTGCTTGAACAT GGGAGGCGGAGGCTGCAATGAGCTGAGATCACACCATTGCACTCTAGCCTGGGAAACATTTTGAGC CATCTCAAAAAAAAAAAAAAATTTCTCTCAAAAAAAAAAAAAAAAAAATTCCAGAATGTTAGCAGAG AAC ATCACACATCCCAAACCAGTAATTACAATTTTCTACCTTTTGATATTCTAATATCCCAACATACTAT TTTTATTACCAAAATGCTGGCATTTTTGGTGCTGCAACACCATTTATCTGAAATAACTTAAAAGTTTTAT TAGAATTCTTGGCTTTCTCCAATCTCTTGCCACTTCCCTTCCCTGCCCCTTTACAAATCCACCAGTCAG CAAGAGAAAACAAAAAAGAAACA CACAACAACAGAAAACTGGACATGAAACTTGCAGGAGCATCTCTC AGGTAAGGAGGAGAGGAATCGGACCCCAGTTCATGATACTCCTTTTGGGGAGGCTGACAAGAGAAA ACAAGTCTGCTGTAGCACAGAACCCTCCAACATAGCAGAAAAGCTGCCCTGCAGTGGGTGGTAATAA AGCCTCCTCACACTGCAGGAGGGCTCTGA AGCTTAACTGAACCAGCTACACCTAAGGAGGTAGACCA AAGAGCACCACCGAAGAACAGAGACAGACCCTGCAGGAAGTGGCAGATCAGCAGTGGTCACAATGA CCAGTCTGGCTAT ATT ATT ACGGAGCTGTTTCTTTGGACTTTTAAACGAAACCTTTAAAAATTTT ATACA ATGAAAACAGGGAACAAAATGCATCTCTATTCCTATAAG TGTTATGTGTGTTACATTAACATTTTGAATT AAACAAGAATGCATATATTTAGAAAGCTGAAAGAAACACGAAGAAGCTTCCAGGTTTCCACATAAAAG TGGTGGGCTGTATCGATCACATCCTACTCACATCTCTAAAAAATCTACCCGGATCAAAAAGGGGAAAATA AAAAAAAAAACCTATGACTTAGGTCTAGAGTAAAACTAGGAGACAGAACAATA AACTCCAAATACCAAA GAAGTGGGGAAATGAGCAGGGTCCAGCAGGAGCTACATCGAAGAGTGGCTTGTGCGGAATCATACT GATTAGGGATCACCCAAGGCCAGACCCCACCCCCTCCACCACCTGCCCCTCAACAGAGCACTACTG AGTGTAGGTTAGAGCACTGGCAACAGGGTGGTTAAAGGAAGGACTACAGAAAAG TACTTGGGTCCAG CAATGGCAGGCTCAGGAAGGCACCATGCATGAAAGGAAGGGGGGTACCTTCAAAAGCAGAAGTGTC CCTTAAGCGGCTGTAAAGGGGTGGAAGCAGCTAATGAAAAAGAGTCTTCATTAAGCTACATGGAGCT GAAAAATCAGAAAGTGGTGATTCTGCCCTTACTAAAGCAACAGAAGAGGGATCCC TTCAACCAAGAC CCCTAAAGCCACACAATTCCTCCCTGCTCCACCATGAGGTCTAGTAATAACAGGTCCAGAAAAAAGTA ACATCTGTTATAGAAACATAAACAAGAAAAACAGAATTCGGAAGTCTAAATAAAGTTATTATGGGAAGA GTCTGGCGAATGAGAAGCAAAACTTTCCGGTAGACAAAAGTAGACCAGAAAAATTCAGTCATAAACAA TGGGAAACTAG TAACACCACATTCCAACACAAAAGGAGAATGCAGCAGCAGACAAGACAGACCACCA GTGATGAGAAATACAAATTCAGAAAGAAATGAGCACATCTTAAATAAAAATAAGAATACTAAAAAAATAC TGAAGAAATATGCAAGGTAACTTTGGAAATAAAGGCTAATTTTATTATAAGGTGACCAAAGAAGAAGC AGTATGACTAAAAATTTCTACTGAGGACAGACTCT AGAAAATTAAAAAACAAGAAAATGAATAAAATAA ACATAACTAAAGAAATGCATATCAAAGCATAATAACGAAAAAGATTAATAGCTAACTACATAAACATAA AACCTTTTCATTTGGCAAAAAAATCCTATAAGCAAGGTTAAAAGACAAATGACAAACTGGGAAAAAATAT TTGCGAATTTACCAGCGTTAAAGGACTAATCTCCTTAACATATAAAGTTTCTAAAAGTGAAGA AAACGA CCAGCTGAGCAGCAAAATGAGCAAAAGACTATATAAAACTATAAACAGCTCTACAAGAAAAAATGTCC ATTATCATTCATAATTGAGGTAAGCTCAAAAATTGTAACTATAGTAAAATACCATTCTCAATTGGCAAA TAAGTAACATCCACATTTAACAACACATTCTGTTTGGAAAGTTTTAAGAAAAGAGATACTGTTGTAAA CTGCTGGTGG GAATGCAAAATGTTATTTTCTGTGAAGGAGGATTTGGCAGTATCTAGCAAAATTACA CATGCATCTACCATTTGATGCAACAATCCCACTTCTAACAATTTATCTTAATGATACTTTACATATGTAC GGAATAATGCATGAACATTAAGAGGATTCACTGTGACATTAGTACTAACAGCAAAAGGTTAAAAATAA encenn / Lznz / B / YiA i CCTCGATGCCCATAAATATTGATAAGCTATGCTGCATCCACACAAAGGAGCAGTATTCAGTCATACAA AACAAAATGGAAAACACCTCTGCAATAATGTGGGATGATTCTCAGGATACACTAGGAAGATTATTTTC CTAGTTCTGTCCTCTGATAAGGCCTACAAGCAGTAACGTTCAAAAGCAAAGGCCATACTTTGCATCTA AAATCTGACTTC TAAATGCCATTTCCCAACAATTTATTGGAAAAATAACTTATTCCAGGCCTGAGAATG AATGTTCGAGATTAGTTAGAAATCTCAAAATCTAATAGGGTCATTTTAAAAGCACACGATAGCTAAGCA ATTTGAATATCATTTAGAGTAATGACTGTGAAACGTATTAAATACAAAAACATTCATTAGTTCGTAATATTCAAAAAGGCAGCAAAAACCAACCAAAAAACA AAATTAAATTGTCACTATTAAATTATTACATTAACTC CTTACTCTAAAAACCTTAAATCTATTTTATCATGCCTTTTCTGTAGAACTGTTTTTCAAGGTAATCAAAT GGCACCCAATGATGAGAAAAAAGAATGCCAGGTATATATGTAGGACAAGCAGATGGAAATTTTTTTCCCAAACAGCCATTTTGCAATCCCCAATGAGATAACAGATTAAGGTA ATGATACTGATAAATACGAAA ATCAGGTGAAGGGCAGGTAGCAGGTTCTGGAAAGATGATGATGGCAACGACATAGTTATTATTATTAT TATTTTTTGTTTTATTCCCTCCCAACCTCCCCTACAAAAACAGCAAACTGAATGAGAAAACCAAAGACC CAGAGACATTATCTACAACAAAACCATGAACCATTGCATATAATTGGACAGAAAACAAAGCT CTGACAA CTACAAGACTGGTTAGTAAGGAAGCAGATGCAAGGTAACTGACTGGGTTTCTGACAGCCCTGAGAAC ACTGCCAACCCACTGGAAAGCACAGGCCAATCTGAAAACAGGGCTTAAAGTTTTAAAAAGTTCTACAG GATCTAATTTGCAGATGATTACAAAGGGATCATGATGTAGTAAGCTCTGGGCCCTTAAAACACCCGAA TA CCAAACCCCCACCAGAAACAAACCTTGTACCGAGGAAAAACTTCTGGGAATAACTTCCGAATGGA CCAGGTCAGTAATAAAAACCAAAAAAAAGTTCAAATATATGTGTGGGATAGAGGAGTAAAGAAGGCAG TTTCAGAAAGCACAAGGGCATATTTTTTGACCATTTTACAAAAACACAGACTTCTCCTCGTCCCTAAAAA GCGAAAAAAGTTATCCTG GCCCATCTCTCCCTCGTCCAAGTATGAGAAACTCATTTCACTCACACACA CACACACACACACACAATAAATAAATAACAGAACAGAGTGAAACAGTGTAATTATTAGAAAAAAGTA TGTGCATATACATGAGAATGGTGTCCCTAGAAAATCAAAGTACATGAAACAATATGCAAATAAAACA TGAAAACTGTAAACAAATTTCAAACTGAGCTAAAAAG AATTTAAAAAATAACAAATCATTAGAAATGGG AAATTCTGAATGAGGGTAACTGAAAAAAAAGGAAGACATGACACAACTAAGGAGTAATTAGAAATGCA AGGAAAAAAATCCCATCAAATACAAAGAAACTAAAACTAAACTAGAGAAACATAAAGGTGAATAAAAC AGAACAATAATACCAGAACCTGAAGGCAGAAAGAAAAATCTTAAAATCAAAAAGAAAACAAAC CCATGCT TGAGACTCTCCTTGCTGGTCCAGAGCCACAGTGCTGCTGTGTACTGGCAGGAGGAATTCTGCTATAA TTGGTCCTGGCAGTGTTCACCTTTTCCTGCAAGTGTTCCACAGCCCAGGGACACAATGTGGTCAGGAG CACTGCCAGGAACACCAGCAAGGGGGAGCCTGCCACACAGGCACAAGGCTCAGGA AGCACTCTCC AGCCCACGAAAATCTAGTGGGGGTCCTCTTCCCTCACCCAAACACACTCTGCGCAGCT SEQ ID NO: 2 artificial / synthetic sequence of shRNA 5'- TGCTCTTCTTTCTACTTTATTCTCGAGAAL4AAGTAGAAAG / IAGAGCA -3' encenn / Lznz / B / YiAi SEQ ID NO: 3 Artificial / Synthetic 551 Ribo Sequence 1 GAAATAATAATCTGATGAGGCCGAAAGGCCGAAACTAAAAG -3' SEQ ID NO: 4 Artificial / Synthetic 551 Ribo 2 Sequence 5'- GAAAGAAGCTGATGAGGCCGAAAGGCCGAAAAATAATAATG -3' encenn / Lznz / B / YiAi SEQ ID NO: 5 UBE3 A-ATS Artificial / Synthetic White String 5'- TGCTCTTCTTTCTACTTTATI -3' SEQ ID NO: 6 UBE3 A-ATS Artificial / Synthetic Sequence 5,-CTTTTAGTCATTATTATTTC -3' SEQ ID NO: 7 UBE3 A-ATS Artificial / Synthetic Sequence 5'- CATTATTATTTCCTTCTTTC -3' SEQ ID NO: 8 Artificial / synthetic microRNA sequence 5'- TCCTGAATAAAGTAGAGAAGAGCAGTCAGTCAGTGGCCAAAACTGCTCTTCTTTCTACTTTATT AGC -3' SEQ ID NO: 9-508 UBE3 A-ATS Artificial / Synthetic Sequence TGTGGAGAATCATTGATATAT GTGGAGAATCATTGATATATT GTATATGAGAGTTCCATTATT TGGCTGTGGAAACGCTTATTT TGGATCGATGATGAGAATAAT GGATCGATGATGAGAATAATT GCCCTCCAATAGGACAAATAA TG ACCCAAG ACTTG CTTTAAT GACCCAAGACTTGCTTTAATT TGTGCTGAAAGAAGGAAATAT ATATGGCATGCCTCTATTAAA TATGGCATGCCTCTATTAAAT ATGGCATGCCTCTATTAAATA TGGCATGCCTCTATTAAATAA GGCATGCCTCTATTAAATAAT GACAGTGGAACCAAGTTTATT GAGACTCCATGGTTCATAATA AGACTCCATGGTTCATAATAT TTGTGGTCATACTACATTATA TGTGGTCATACTACATTATAT GTGGTCATACTACATTATATT TTGCAACAAGGTAAGTTATAT TGCAACAAGGTAAGTTATATA TTGATTGATGCCCTCATAATA TGAAGTTGGGTAAAGTATAAA GTCAATACACAACTGATAAAT CAAAGAGTTTCAGCCATAAAT CATGCTTTCCAGAGGAAATAT TCCAGAGGAAATATGTTTAAT TTTAATCATCTGCCCTATATT TTAATCATCTGCCCTATATTA TGCAAGATACCATACATTTAT GCAAGATACCATACATTTATA GGTCCATGTGATTTCTTTAAT TGCCATAACTATAGCATTTAT GGATACCATCCACACTATAAA TGTGTTTCCTTCCAGATAATT GTGTTTCCTTCCAGATAATTT GTGTGCTGAAAGGGCTATAAA TTGAACCAACCACCCTATAAA TAAACGTTGTATGGCTTATTT ATCCCTGTGTACACAATATTT ATGTGTGGTAAAATCCATTATT TGTGTGGTAAATCCATTATTT ATGAGCATTTGGCAGTAATAT TGAGCATTTGGCAGTAATATT GAGCATTTGGCAGTAATATTA AGCATTTGGCAGTAATATTAT GCATTTGGCAGTAATATTATT GAGACTCTGCTGAAGTTTATA AGACTCTGCTGAAGTTTATAA CAGTTATAGAAGTGCTAATTT TATGATGACCTCCTGAATTAT GGGTCTGGTGTTTCATTTATT GGTCTGGTGTTTCATTTATTT GGGTCTCATTATAGTTAATAT TAACAGCATGTCAGGTAATAA GCAGAGCCCTATTCCTTTAAA CTCCTAAATGTTTGGAAATTT TTAGCATTTCTGACCTATTTA TAGCATTTCTGACCTATTTAT AGCATTTCTGACCTATTTATT ACAGGATATAGGGAATAATTT CAGGATATAGGGAATAATTTA TAGCACTGAAATGCCTATATT AGCACTGAAATGCCTATATTA GAGCAGAAATCAATGAAATAT ACTTGTAACCAGACCAATTTA CTTGTAACCAGACCAATTTAA ACTCAGTGAACAAGTAAATAA TAGCCCTGTATCAAGTAAATT ACAAGATTCCAGAACATTTAA CAAGATTCCAGAACATTTAAA GAGAGTTACCCAAAGAATTTA AGAGTTACCCAAGAATTTAA AGAAGAAAGGTTTGGAAATTT AGCCCAATCTATAGGATTTAT GCCCAATCTATAGGATTTATA CCCAATCTATAGGATTTATAT CACATACTACAGGGCATATAA ACATACTACAGGGCATATAAA TTAAAGAGTTGCCACATTATA GTTGCCACATTATACATAATA AGACATTGAACCAGCTATTAA GACATTGAACCAGCTATTAAA AGGGTTAAAAAGGTATAAA ATACCCGAGATGACCAATAAA CAAAATCCACGAGAAGAAATAA ACTTGTGTTGATGGTATTATA CTTGTGTTGATGGTATTATAT ATTCATTGGAAAGGGTATAAA 100 CAGTAACAAGAGCCCATTATT 101 AGTAACAAG AG CCC ATT ATTT 102 GCCCAAGAGATCCACTTTATT 103 CCCAAGAGATCCACTTTATTT 104 TTTCATCTCACCCAGAATATT 105 TGTTATGAGATCCAGTTATTT 106 ACTGAACTGTGAGCCAATTAA 107 CTGAACTGTGAGCCAATTAAA 108 AGTCTTAGGTAGTTCTTTATA 109 CAAAGGCAGCAGCACAATAAT 110 AGACTGGCTATTTG AAATTAT 111 GACTGGCTATTTGAAATTATT 112 CACCATCAAGAGAACTAATAT 113 ACCATCAAGAG AACTAATATA 114 CCATCAAGAGAACTAATATAA 115 GGAAAGTACATAGTCAAATTT 116 CAATGCATACTACAGTATAAA 117 AGTCCTTACGTGTCAATAATT 118 GTCCTTACGTGTCAATAATTA 119 GACACATACAGGCTGAAATTA 120 ACACATACAGGCTGAAATTAA 121 CACATACAGGCTGAAATTAAA 122 CAATATTGAAGCACCTAAATA 123 ATGGATCTAACAGACATTATA 124 CATTCTCCAGGATAGATTATA 125 ATTCTCCAGGATAGATTATAT 126 CAAGATGGAAACTGGAAATTT 127 TTCTATGAGGTAAGCTTATAT 128 TCTATGAGGTAAGCTTATATT 129 ACAAAGATCAGACAGAAATAA 130 CAAAGATCAGACAGAAATAAA 131 ATACCACAGACATACAAATTA 132 TGAAGACTGCCAACCATTTAA 133 GAAGACTGCCAACCATTTAAA 134 CTAATTCAGCAACACATTATA 135 GATGCAGGATAGTTCAATATA 136 ATGCAGGATAGTTCAATATAA encenn / Lznz / B / YiAi 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 TGCAGGATAGTTCAATATAAT GTGTCTGTTGGCTGCATAAAT CTTTGTAG ATTCTG G ATATTA G CAG AAGCTCTTTAGTTT A AT CAGAAGCTCTTTAGTTTAATT CATCCTGTTACTGGGTATATA GTATATACCCAGAGGATTATA TATATACCCAGAGGATTATAA ATATACCCAGAGGATTATAAA T ATACCCAG AG G ATTAT AAAT CCCTAGAACTTAAAGTATAAT TGACAAACCTGGAGGTAATAT GACAAACCTGGAGGTAATATA GTCCATTCTCACCACTTATAT TCCATTCTCACCACTTATATT CCATTCTCACCACTTATATTT CATTCTCACCACTTATATTTA GTAGATGACATGATCTTATAT GAATAGAGAGCCCAGAAATAA ATGCTTGACATCACTAATAAT TACACTGTTG GTGTGAATTTA ACACTGTTGGTGTGAATTTAA CACTGTTGGTGTGAATTTAAA GGTATTTGCACACTCATATTT GTATTTGCACACTCATATTTA ATAAAGAGAACGTGGTATATA AGACACAGTGGAATCTATTTA G GTACAAACTTTCAGTTATAA GAAGGCACTGATATGTTAATT AGGCACTGATATGTTAATTAT ATCCATTC AAG CTAG ATTATT TCCATTCAAGCTAGATTATTT GGCATGGTGGCCCTCAATTAT GCATGGTGGCCCTCAATTATA CATGGTGGCCCTCAATTATAT ATGGTGGCCCTCAATTATATA TGGTGGCCCTCAATTATATAT GGTGGCCCTCAATTAT ATATA pncrnn / Lznz / B / YiAi 175 GTGGCCCTCAATTATATATAT 176 TGGCCCTCAATTATAT ATATA 177 GGCCCTCAATTATATATATAA 178 ATGAACAACAATGGGATTTAA 179 TGAACAACAATGGGATTTAAA 180 GAACAACAATGGGATTTAAAT 181 AGCAATAGTGGAGAAATATAA 182 GACCTAAACCCTATCTTATAA 183 ACCTAAACCCTATCTTATAAT 184 CCTAAACCCTATCTTATAATT 185 CTAGAGCAGCAATACTAATAT 186 CTGAAGTGCACATG GAATATT 187 TCTTCAGGATGACACATATTA 188 CACAATGATATGGAGATTTAA 189 CTCAATCCAATAACCTAATTT 190 GTAAACAGAAGGAAGAAATAA 191 GATATCACCTTACAGAAATTA 192 AGGTCCGTATTACCCTTATAT 193 CATCTAGCCTTTCTGATTTAT 194 ATCTAGCCTTTCTGATTTATA 195 TCTAGCCTTTCTGATTTATAT 196 CTAGCCTTTCTGATTT ATATA 197 AGTCACAACTCAGATTTATT 198 GGCCTCACAACTCAGATTTAA 199 GAACAGAGCCCTCAGAAATAA 200 GGAAAGGATTCCCTATTTAAT 201 GAAAGGATTCCCTATTTAATA 202 GACAAACGGGATCTCATTAAA 203 CATCTGACAAAGGGCTAATAT 204 ACAATGAACTCAGACAAATTT 205 CAATGAACTCAGACAAATTTA 206 GTTAGAATGGCGATCATTAAA 207 CAGCCATCCCATTGCTATATA 208 AGCCATCCCATTGCTATATAT 209 GCCATCCCATTGCTATATATA 210 CCATCCCATTGCTATATATAT 211 CATCCCATTGCTATAT ATATA 212 ATATACCCAAAGGACTATAAA 213 TATACCCAAAGGACTATAAAT 214 ATATGCACAGGTATGTTTATT 215 GAAAGACACTGATTGTATTTA 216 ACATAGCCCTAACCATATAAA 217 CCTCACACAAAGACCTATTAT 218 TGGCAGAGATTTGGCAATTAT 219 GGCAGAGATTTGGCAATTATA 220 AGAACAACAAGGAGGAAATTT 221 GAACAACAAGGAGGAAATTTA 222 GAATGGAGTGAAATGTTTAAA 223 TCTGATTTCCTTGGGTTTATT 224 CTGATTTCCTTGGGTTTATTT 225 TGCTCTTCTTTCTACTTTATT 226 GTAAGCATTTAGTGCTATAAA 227 TTAGTCACATCCCACAAATTT 228 ATGGTCTGTGCTGTGAATATT 229 TTGAAGTCTCCAACCATAATT 230 CAGTTTGTGCATCACATATTT 231 TGCCCTCTTGGTGGCTTATTT 232 TCCTAGGTCATAATGATAATT 233 CTCCACATCCTTACCAATATT 234 CGCTTATCAGATATGATTTAT 235 GGTCTATACATGTAGATTATT 236 TCATAGATGTATGGGATTATT 237 CATAGATGTATGGGATTATTT 238 CTTGTAACTCCTTGGTTAAAT 239 TTGTAACTCCTTGGTTAAATT 240 TGTAACTCCTTGGTTAAATTT 241 GTAACTCCTTGGTTAAATTTA 242 TCCTTTCTGATGCTGTTTAAA 243 CCTTTCTGATGCTGTTTAAAT 244 CTGAAACTTTGCTGCATTTAT 245 TGAAACTTTGCTGCATTTATT 246 GAAACTTTGCTGCATTTATTA 247 TTGCTCTGTGAATAGATAATT 248 TGCTCTGTGAATAGATAATTT 249 ATATGTTGATCCACCTTTATA 250 TATGTTGATCCACCTTTATAT encenn / Lznz / B / YiAi 251 ATGTTGATCCACCTTTATATT 252 TCTTTGGCTACTTTGTATAAT 253 CTTTGGCTACTTTGTATAATA 254 TAAGTGCATAGAGCCAATAAA 255 ATGCACATGATCTTCTTAATT 256 TGCACATGATCTTCTTAATTT 257 TGGCTTAAAACAAGAGAAATTT 258 GGCTTAAAACAAGAGAAATTTA 259 ATATGTTGATCCACCTTTATA 260 TATGTTGATCCACCTTTATAT 261 ATGTTGATCCACCTTTATATT 262 TCTTTGGCTACTTTGTATAAT 263 CTTTGGCTACTTTGTATAATA 264 TAAGTGCATAGAGCCAATAAA 265 ATGCACATGATCTTCTTAATT 266 TGCACATGATCTTCTTAATTT 267 TGGCTTAAAACAAGAGAAATTT 268 GGCTTAAAACAAGAGAAATTTA 269 ​​AGGTATCAGAGTAGTATATTT 270 AGTTCATCGTTAGTGTTATAT 271 GTTCATCGTTAGTGTTATATA 272 ACCACCATGCCCAGCTAATTT 273 ATGACCCATTTGAAGTTAATT 274 TGACCCATTTGAAGTTAATTT 275 ATGCTGGCCTCACTGAATAAA 276 TGCTGGCCTCACTGAATAAAT 277 GCTGGCCTCACTGAATAAATT 278 TGTTCCCTCCTCTTCAATTAT 279 GTTCCCTCCTCTTCAATTATT 280 TTCCCTCCTCTTCAATTATTT 281 TTGGTAGGTTGTGCGTATTTA 282 ATTAGTTGGCATGCAATTATT 283 ATTCGTAGTTCTCTGAATAAT 284 TTCCTTCTGTTGGCCTTTAAT 285 TCCTTCTGTTGGCCTTTAATT 286 CCTTCTGTTGGCCTTTAATTT 287 GAAAGCATTTAGAGCTATAAA 288 CTTTCACTACCTGCCATAAAT 289 TTTCACTACCTGCCATAAATT 290 TTCACTACCTGCCATAAATTT 291 TCCTTGACCTATTGGTTATTT 292 CCTTGACCTATTGGTTATTTA 293 CTTGACCTATTGGTTATTTAA 294 TTGTGATCACAGAAGATATTT 295 TGTATAATCGCAGTCTATTAA 296 TCGCAGTCTATTAACATTTAT 297 CGCAGTCTATTAACATTTATT 298 GAGTGGTAAAGTCTCTATTAT 299 AGTGGTAAAGTCTCTATTATTATT 300 AGCATAAGCTATGTCATTAAA 301 CTCTTCATTTCCTCAATATT 302 TGAGATACCTAGAACAATATA 303 GAGATACCTAGAACAATATAA 304 CTCTTTCTCTGTGAGATTATA 305 ACAACAGCCTGGAAGTATAAT 306 CAACAGCCTGGAAGTATAATT 307 ACAGCCTGGAAGTATAATTAA 308 ATTCAAACTGATGCCAATTTA 309 TTCAAACTGATGCCAATTTAA 310 AGTCAACACACCAATATTAAA 311 AGCTCCTGTTTGAAGTAAATT 312 GCTCCTGTTTGAAGTAAATTT 313 GCCTTCCAAGGTTTCTATTAA 314 TGTGGGTCTCTTTGGATTTAT 315 TATGGTTCTGTAGAGATATTT 316 TGTTCTCAATTTCCCTATATA 317 GTTCTCAATTTCCCTATATAA 318 AGGTTGGAACATTTCAAATAA 319 TTACATGGGCTGTTCTATAAA 320 TACATGGGCTGTTCTATAAAT 321 TGTTACTTAAGGTGGTTAATA 322 GTTACTTAAGGTGGTTAATAA 323 GTTGCTCAAGTCTTCTATATT 324 CAACATGCAGGTTTGTTATAT 325 ACATGCAGGTTTGTTATATAT 326 ACGTGTGCATGTGTCTTTATA encenn / ίζηζ / Β / γίΛΐ 327 CTTTATAGCAGCATGATTTAT 328 TGTGTCTTTGGCTGCATAAAT 329 CTTTGTAGATTCTGGATATTA 330 GCAGAAGCTCTTTAGTTTAAT 331 TTTCCCAGCACCATTTATTAA 332 TTCCCAGCACCATTTATTAAAA 333 TCCCAGCACCATTTATTAAAT 334 CCCAGCACCATTTATTAAATA 335 GTTGTAGATGTGTGGTATTAT 336 TTGTAGATGTGTGGTATTATT 337 TGTAGATGTGTGGTATTATTT 338 GTTCTGTTCCATTGGTTTATA 339 TTCTGTTCCATTGGTTTATAT 340 GGATGGCATTGAATCTATAAA 341 GATGGCATTGAATCTATAAAT 342 CCTAATTGAATACCCTTTATT 343 GGCTGTGGGTTTGTCATAAAT 344 GCTGTGGGTTTGTCATAAATA 345 TGTCCCATCAATACCTAATTT 346 GTCCCATCAATACCTAATTTA 347 TCCCATCAATACCTAATTTAT 348 CCCATCAATACCTAATTTATT 349 TTGTCTTTGGTTCTGTTTATA 350 TGTCTTTGGTTCTGTTTATAT 351 AGCATGCTTTGCTGGTATTAA 352 GCATGCTTTGCTGGTATTAAT 353 CATGCTTTGCTGGTATTAATA 354 ATGCTTTGCTGGTATTAATAT 355 TGCTTTGCTGGTATTAATATA 356 GAGAGTTAGAACCTCAATATA 357 AGAGTTAGAACCTCAATATAT 358 CCACCACGCCTGGCTTTATAA 359 CACCACGCCTGGCTTTATAAT 360 ACCACGCCTGGCTTTATAATT 361 CCACGCCTGGCTTTATAATTT 362 GTCTAGCTCCAAGTGATATAT 363 TTTGCTTCTGTCTGAAATATA 364 TTGCTTCTGTCTGAAATATAT encenn / Lznz / B / YiAi 365 TCTTAAGTCTGTGAGTTTATA 366 TCTCTGATTTCCACCTATATT 367 CTCTGATTTCCACCTATATTA 368 GTATATACTCCAGAGAAATAA 369 CACCAGAACTTGAACATTAAT 370 ACCAGAACTTGAACATTAATT 371 CCAGAACTTGAACATTAATTT 372 GTCTGGAACTCCTGGAATTAA 373 CTTTCTGTGCCTGGCTTATTT 374 CAGGATTTACCTTCCTTTAAA 375 TCTGTTGATGGGCACTTAAAT 376 CTGTTGATGGGCACTTAAATT 377 TCATAGCGGCTGTACTAATTT 378 CATAGCGGCTGTACTAATTTA 379 TTTACCCATTTCCAGATATAT 380 GTGTAAATAAGGGTCTAATTT 381 TGGTTATGTCATCAGTAATTA 382 CCTTGCATCCTAAGGATAAAT 383 GTGAATCCAGTTTGCTAATAT 384 TGAATCCAGTTTGCTAATATA 385 GAATCCAGTTTGCTAATATAT 386 CCATGTTCATCAGGGATATTA 387 GTGTCTTTCTCTGGCTTTAAT 388 TGTCTTTCTCTGGCTTTAATA 389 GTCTTTCTCTGGCTTTAATAA 390 TTGTGATCCTTCTCTTTATT 391 GTAGGTTTGTATCGCTATAAA 392 TAGGTTTGTATCGCTATAAAT 393 AGGTTTGTATCGCTATAAATT 394 GGTTTGTATCGCTATAAATTT 395 TCATTTGTCTCAAGGTAATTT 396 TTTGGGAGCATATTGTTTAAT 397 TTGGGAGCATATTGTTTAATT 398 TGGGAGCATATTGTTTAATTT 399 TGGATGGAATGTTTCATATAT 400 AGTATTGAGGTCCCGTATTAT 401 GTATTGAGGTCCCGTATTATA 402 CTCCCCTCTCACATCATTTAA rncrnn / Lznz / B / YiAi 403 TCCCTCTTCACATCATTTAAA 404 TATGTCTTCTTGGTGAATTAA 405 ATGTCTTCTTGGTGAATTAAT 406 CTGCTCTCAATTTCCATTTAT 407 TGCTCTCAATTTCCATTTATA 408 GCTCTCAATTTCCATTTATAT 409 TCCTTCAGCACTTTGAATATA 410 TCAGCTATTACTTCCTTAAAT 411 CAGCTATTACTTCCTTAAATA 412 TCCTTAAGGACCTCCTATTAT 413 GCTTGACCTCTAAACATATAA 414 CTTGACCTCTAAACATATAAA 415 ACCAATACCTTGTGTAATAAA 416 TTGACACTGGCTCTCTTTATA 417 TGACACTGGCTCTCTTTATAA 418 CAGAAGATGTGTTTGATAATA 419 GTTTGACGTGAAGAGTTTAAA 420 CTCTGAGCTTCAGTGAATTAT 421 AGGGTTGAATGCTGGATTTAA 422 GGGTTGAATGCTGGATTTAAA 423 GGTTGAATGCTGGATTTAAAT 424 GTTGAATGCTGGATTTAAATA 425 AGTGAAAGCAAAGAGAATAAA 426 CATGATGTTCCAAACTTTAAA 427 AGGTGGCCAAGGGCCTTAATA 428 GCCCAGCTGGCTCTGTAATAA 429 CCCAGCTGGCTCTGTAATAAA 430 CCAGCTGGCTCTGTAATAAAT 431 TGGTGTCATCGGGCCATATTT 432 TAACTAGGTCAACAGAATATT 433 GCAAAGTTAATCCTCATATAA 434 GCAGCATCTGTTCTGATTAAA 435 CAGCATCTGTTCTGATTAAAT 436 AGCATCTGTTCTGATTAAATA 437 GCATCTGTTCTGATTAAATAT 438 CTGCACAACTGACCCTTTATT 439 TGCACAACTGACCCTTTATTA 440 TGATGGCTTTCCTACTATTTA 441 GATGGCTTTCCTACTATTTAA 442 AGCTCAGCCATCTGGTTTAAA 443 CTGACTGCCTTAGACTAATAT 444 TGACTGCCTTAGACTAATATA 445 CAGCATTTGACAAAGAAATAA 446 AGGATATGGATGATGTATATA 447 GTCGACCCTAAGAAGATAATA 448 AGAAACCTGAACAAGTAATAA 449 GAAACCTGAACAAGTAATAAT 450 AGTCACACAACAGACTAAATT 451 GTCACACAACAGACTAAATTT 452 AGCGAGAGTGTCCTCATTTAT 453 GCGAGAGTGTCCTCATTTATA 454 CGAGAGTGTCCTCATTTATAT 455 ATCCTCTATCTCTGTTAATAA 456 AGCAAGTGCTATTCCATATTTT 457 CTGGAGTCCATGGAGAAATAT 458 CCTCCAAGGACATACTTTATA 459 CTCCAAGGACATACTTTATAA 460 TCCAAGGACATACTTTATAAT 461 CCAAGGACATACTTTATAATA 462 GTGAGGGCAATGGTGAATATA 463 TGAGGGCAATGGTGAATATAA 464 CGAAAGGCAAGCTTCTTAAAT 465 GAAAGGCAAGCTTCTTAAATA 466 GGCAAGCAAGGCAGGATTTAA 467 ACAGGAACCTGGCTCTAATTT 468 GGGACCTCCTGACATTTAATT 469 GGACCTCCTGACATTTAATTA 470 GACCTCCTGACATTTAATTAA 471 GTGGGAGCTTGTTACATATAT 472 CTAAGTCTTCTCATCTATATA 473 TTAGGTGGTCATGAGATAAAT 474 TAGGTGGTCATGAGATAAATA 475 AGGTGGTCATGAGATAAATAT 476 GGTGGTCATGAGATAAATATA 477 GTGGTCATGAGATAAATATAT 478 CACAAAGCACATGGCTAAATA 479 ACAAAGCACATGGCTAAATAA 480 CGGTTATGTAGAAGCTATTTA 481 GGTTATGTAGAAGCTATTTAA 482 AGCCACCCTTAATTGAATAAT 483 ACTACCCTTTACTGGTAATTT 484 TAATAGGCACTAGAGAATAAT 485 ATTTGGGCCCAAGTGTATATT 486 TTTGGGCCCAAGTGTATATTT 487 TTGGGCCCAAGTGTATATTTA 488 TGCCTGCTGTGGGTGATTATT 489 GCCTGCTGTGGGTGATTATTT 490 GGGATCTTTAGGGACATAATT 491 GATGACACTACGTAGATATAT 492 TGCTCTTTCAGTTTGTAATAA 493 GCTCTTTCAGTTTGTAATAAA 494 GTCTTTCCATGGGTCTAATTT 495 TCTTTCCATGGGTCTAATTTA 496 ATCAGTTTCTCTAGGTATTAA 497 TCAGTTTCTCTAGGTATTAAA 498 AGGCCAAACTCTCTCTTAATT 499 CTTACCCAGTCACTGTTAATT 500 TTACCCAGTCACTGTTAATTA 501 ACCCAGTCACTGTTAATTATT 502 CCCAGTCACTGTTAATTATTA 503 CTCAACAGCTTCAACATTATA 504 TCAACAGCTTCAACATTATAT 505 ATACATCTTGACTCCATTATT 506 CCCAAACTGGACAGATATATA 507 CCAAACTGGACAGATATATAA 508 CAAACTGGACAGATATATAAT pncrnn / ίζηζ / ε / γίΛΐ SEQ ID NO: 509 Human UBE3 A sequence CAATGAGAATAAACTCACTGTAGCTCCATGCTACAACATGGATACATTCCAAAAACAATTTTGATGAAA GAAGGTGGACACAAAAGAATACATGCTGTATGACTCCTTTTACATAATGTTCAAAAAACAAGAAAAACT AAACCATAGTATTTAGCAATTCAAACTTAGATGGCAAAAGTATAAAGAAATGTAGGGAAATTATTTCG TAAATGTCTCCT CTAGGGAAAAGGGAGGATTAAGTCAAGCTCATCCATCACTCCATACTGGCCCTTCC TCGCCAGTGATCTCACATGTTTATTCCAACAAGAGAGCTGGAGAAACTGTGTTTGTGCTATATCAACA ATTCTCAGTGAATGTCTTGTTGACTGGGAAAGCAATGTGGGTCCTACTTTTCTTTCTTTCATTTTGTAA AACCATTTCTGATGAGCATGAATGAGTCCTCCATTTCTTAAGTAACTGACAGCACAGGTTTGATATCA GCAATCAAAGATCTGCCAGGCCTTGTTTATCATGCCTCACCTCTGTTGCCACATGTTTCCCAGGGATC GA TTGAATGTGACTATGAGTAGCTCTCCATGTACACCATCTAGTGTCACTTCTGGGACTTGGGGGTTT CTGACTTACAGTCCTCTTCCCTATCATTTATTTACATATTCAGTAAATAATCATGAACACCTACCTTATGCCAGACAGTGTTCTGGGTGCTAAATATATAGTAGTAGAAGAGATAAAGTTTATGTTTTCATAGAACTTT CAATTCAGTA CATGAGATGGAAAGGTGGACGGTGCCTGTAGTCCCAGCTACCCGGGAGGCTGAAGT GAGAGGACTGCTTGAGCCCAGGAATTTGAGACCAGCCTGGACAACGTAGTGAGACCCTGTCTCTATT AAAGTTTTTTTAAATTACTGATATAATTTAAGGTAGTGGTGAGTACTAGAAAAATGTACCAGGAGAAA AAAACAGAAGCA AAAGTACATGTGGCCAATACTATTTTGATATGTAGAGGCCAGGAAAAGCTTCTG AAGAGGTAAACACAAAGTTGAAGGATGTACCATCACAGAGAGATGGAAGTTTTCCATAATTTCCTTGC ATATACTATGGTGTGACTTCATTTTTCACCCACGTCTGTTAGGCTGCTCAGATAAACTGCTTTTTTTTT AAACGAGATCTAAAGACC ACGTACATTCTTCATAGTCCCTGAATTAAGTATTACCCAAACCATAGCTCA TGGGCCACCTACCTGTTAATTTAATGTCTATGTATGCCTTCACTCTACAATGGCAGGCTTAAGCAGCT GGGACAGAGACCACATAACCCAGAAAGCCTAAAACTTTTATTCTCTGGCCCTTTACAGCAGCAGTCC CTAAACTTTTTGGCACCAGGGACTGGTTTC CCAGAAGACAATTTTTTCCTCCTACTGGGGGTGAGGGA TGGTTTCAGGATGATTCAAGCGCATTACTCTTACTGTGTACTTTATTTCTATTATTATTACATTGTAACA TATAAGGAAATAATTATACAGTTCACCATAATGTAGAATCAGTGGGAGCCATGAGCTTGTTTTCCTGAA ACTAGACAGTCCCATCTAGGGGTGATGGGAGACGT GACAGATCATCAGGCATTAGATTCTCATAAGG AGTGTGCAACCTAGATCCCTTGCATGTGCAGTTCACAATAGGGTTCGTGCTCCTATGAGAATCTAATG CTGCCACTGATCTGACAGGAGGCGGAGCTCAGTAATGTGAGTGATGGGCAGCAGCTGTAAATACAG ATGAAACTTCCTTGACTTCCCTGCCCTCGCCTC CTGCTGTGCAGCAATTTCCAACAGGCCACGACAG GGGTTGGGGACCCCTGCTTTACAGGAAATAATGTGCTGATCCCTGGTTTAGATAATTGATTTTGAAAT TTGATTCTATTTAAAACTATTAGTTTTCCTGTAAGCTCTTCTTTAGCTGCATTTAACTGGTTTTAATATGA TATACTGCAGTATCATTCGATTCAAACTATTTTCTAAG ATTCGAAGATTTGCTGTAACTTATCCTTTTAC CAATGGGTTATTTAGAAGTGTGCTGCTTAATTGCTAAGCTATTGGAAATTTGTCTACTTACCTTTCTGT TCTTAATTGTCAGTTTAAATTCACTGTGATGTGGTCAGAGAATACAACCTAAATGTTATCAATCATTTGAAAAAATTTTAGGACTTAAATTAGGGGCCAGCATACAG TATACTTTGGTAACTGTTCCCTGTGTAAATAA AAAGAAAATCTGATCTAGAACTGTTAACTGTGGTATCTTACATAGTCAACTTGATTAATTTAATGAATCA TGTTGTTCAAATATTTTATATTCCTGTTGATGCTTTGACAGCTGTTCTAATACTGAGAAGTGTGTGTGA AAATCTCCAACTATTATTATATGATTTTGATGTTTCCTCATCTAAT TCTGTTACACTTTGAAATATAAATT TTGAAGCTATTAGGTGCATATAGGTGAAATATTACATACAGAATATTTTATGATTTTTCTGTTTAATTGA CAGTTTTACTATTACAAATGTTCTTGTGTTCTTCTAGTGATTTTTCTTGCTTTAAAGTCTATTAACTTGA TATTATATAATAATCAACTTTCTTATAGCTATTGTTTGCATGTTATAACGTCTA TCCTTTACTCTCCATT TCACTGTGTTCTTATATTTAAACTGCCTTTCTTATCAATAGCACATACTTGAGTCTTGTTTTTGTATGCA GTGTGACAATCTGTCTTTAATTGAAATGTTTAGTTATACATATACAATATAACAAATAAAATAGATGGAT TTATATCTGCAGTCTTGCTATTTATTTTCTATTAACTCCATCTATTTTCATTTCATATTTTTTTC TCTTCTG CCTTCTTTTGAATAATCAGCTTTTTGCTATTCTATTATTTCCCTCTATTAGCTATTCTTGAATATTTTAA encenn / ίζηζ / Β / γίΛΐ TAATTAGCTAGAGATTCAATACAAACTCCTTATGTTCTACAGTCTACCTTAAGCTAGTTGTTTTTACCAC CTCCTGAGGGTGCAAGAACTTTACAACACATGTAATCAATTCACTGTCCTCAGTCTTTGTGCTATTGCT GGCATATATTTTACTTCTCCATGTTATATATTTCACAATACATCATAATTATTTTTAACAGTTATTTGTT TATATTTTTCAG ATATATTTACCCAATCCAGTGCTCTTTATTTCTCTTTCTTGCAGTTTTATGCTTTCATC TGGGATAACTTTCTTTCAGCCTGAAGAGTCTATTTTAAAAATTTTTTTCTAGAAAAAATCTGCTGGCCATG ACTATTTTCAACTTATTTTGTCTAAAACATTTTATTTTTACATTTATTTATGAAGAATATTTTCTCTGAGT ATAAAATGTTAGGTTGGCTGCT TTTTTTATTTCAGGTTTCAGAGATGCCTTTCTATTTTCTCCTGGCAC CTATAATTTCTGATAAAAAGTCAGCTGTAAGTTTTATTGTTGTTCCTTTAAAGGTTATGTGTCTCATTTC TCTGACCATATTTAGGGTCATCTCATTCTCTTTGGTTTTCAGCAGTCTGACTGTGGTGTGCTTCAGTGGGGTTTTCTTTTTACTCTACG TAAGATTCACCAGTCTGCAGTCTGTGAGTTGATAGCCATTCAACAAA GAAAAGAACAGCAGCTACCATTGAAATCTCCACCTGATTAGACTTACAATAATCCACACTGTCATTTCC TAATATCCATCTGATTTTTTGCACAAGCCAAACAACCAAGTTAAGTGGGAGAGGTAGTAGAAAGCAAC ACCCCTATGTCTTCCCAATTTTAGGTGGTG GCACTAAATCACTAATATTCTCCTTGAGGCATGGTATTG CTTTTGGTTTATTTTTTTCAAATAGAGGACTACGTTCATAGGTTTATATCACGAGAGTCCCTCATTCTAT GGGTCAGTGGAACAACTGAGGATCTTGTCAGATAACAAGTATGTCTATTACAACTCACATTCAGGATC TGAGGAATTAACAGGATGGCTCATGGACCTACTGGA CCCATTGAGAAATGATGTCAACTGATGTTCAC AAGCCCTCATCAGGCTTGAAGGACCAGAGTGTCTTTATGGTCGCCAGGAATTATTACATGTTAGCTCA GTGACAGTGCCCCCAAATCCCTGAAAGATCTGGATATTTCCTTTCCCTTGGTGAACAGTTATTCTGCT AAACGATCGCGTAGCTCCTTCAGGAGGGCTAGAAGGAAAATATA CAGCATGAACTTATTGGGTTATC CTCAGCTGTACCCAGACTCACCTTCACTCACATGACTCTGTGTCTATGAACTGACTGAGGTTTGGGAT TTGGCAAGGGGCTGTGAATCTCTATTGAGGTGGCTTAAGTCAAGCTTTGGTTTACTCAGAACTAGAAT TGTACTTATCTAAAAGGACACAGTAAACTGATTACCTATTTCAGTCC TTGGGACTTCATGACCAATTCA CCTGTCAAAGATCCCTGTAGGCTAAACTATTCAGATTGCTACTCTAGCTCTTTTCGTGCAAGATTTCACCTCCTAAATTAGACTGCACGTGGCCTGCTTAATGACTTGAACCACAATCTCTTAAATCAAAGTCTTTCCTTCAAAGCTACTTTAGTCCAGCTGACTACAAAGATCATTTAACTGTTTGGTCACTGTGT GCCATGGA CCACTGTCCCACTGCCAGCACTACTTAGATACTTACTGTTTTCAAATCCATTTCAGACACTAGTCCCA GATTTCTATTTCTTTAAGGATCTTTTGTCATCAATTCTGTGTCAATAATACTTGTTGGTTGGAGACAACA GAATCCATAGTAACTAGTCTAGGCAGGCATGTCAGATGATCCTAGATGACCCTTATGCTCAAGTATTT GCCGGA AGGACTCACAGGACTCAGAAAAGCTCTTACACTCATGGTTATAGTTCATTACAGCAAATGGA TACAGATTAAAATCAGCAAAGGGAAAAGGTACATGGGATGAAATCCAGGAGAAACTAGGTCCAGGCT TCCAGATATCTTCTCTGCTGGAGTCACATGGAGATACACTTAATTGTCTCTGCAATAATGTGTAACACA TATGAAGTAGCTTCCT GGTTGGCAAGACTTCATAAATTTTGCCATTATTTGAAGATAACCCACACCTTG GTGTCCAGGGTTTTCACAGGTATTAGTGGTCAGTCACATAGGCATATAGTACCTGTATGACTTCTATT CCAGCCACCGCAAACTTCTCCTCTCCCTGCTGGCTCCTGAGCCAAAAACAGGCATTTACCATAAATCA CTTTGTTAGGATGAACTTATCTGGCC AAACTGATACAGCATGACCCACAGCCTCAGGTATATAAAAACA CCTTCATCAGGCAGAATGTTTCAGGGTCTCAGAGGTTAGTCAGGGGCTAGTCAAGGACCAATCCTGA AGGCAGGCCTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGGGTCTTGCTCTGTCGCCCAGGCTGGAGT GCAGTGGCATGATCTCAGCTCACTGCAAG CTCTGCCTCCCAGGTTCACGCCATTTCCCTGCCTCAGC encenn / Lznz / B / YiAi CTCCTGAGTAGCTGGGACTACAGGCACCCGCCACCATGCCCAGCTAATTTTTTGTATTTTTAGTAGAG ACTGGGTTTCACCGTATTAGCCAGGATGGTCTCGATCTCCTGACCTGGTGTTCCACCTGCCTCAGCC TCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCAGCCAAGGCAGGCCTTTTTTTGGAAC C TACAGGGTTTGACCAACCCAGGACTGCTGAGTTAACCCTTTCCTGTGCAGCAAAAAGATTTATTTA AAAAAAAAAATGGAAAATCACAGTTTAATCAGAAGGGATGAAAAGACAGCTTCTAGCTTGTATTTCTGA GAACATTTCCCAGAACCATATCATAAAACTGGCCTGCTAAGGAAGATGTCTCTGCTAACCCAGAACAA GGTTAAATT GCATGTGGTTTATGGTTATATATGGGAATGCCCTGGTTCTTATGGAAAAGATACAGGGA TAAAGTGTTACAAAGTCTGTAACTTATGACAAATGGGTCCATAGCTGGAGATAACAGATAAATGGATAGATAGAACAAATATGGCCAGATATAAACTACCAGGACATCTAGCTAAGAAAATATGGTTATTGATTAT ACTATGCTCTAA ACTTTTCTTTAGATTTAAAAAATGACCAAGAATAAGGAAGTACAAAAAACTATGGC ATGTTTCATATGAGAAGTGTTTGACATAAAAGGGAAATTGGGAGGCTGGGTGTGGGGCTCACGCCTG TAATCTTAGCACTTTGGGAGGCTGAAGTGGGAGGATCGCTTGAGCCCAGGAGTTCAAGACCAGTCTG GGTAACATAGT GAAACCTAATCTCTACTTAAATATATATATATAAAATAAATTGAAAAAAAGAGAGAAAT AGGAAAAAAGCTACTGAGAACTAGATAGTAGGTTTAGTAGGTTTGAAAGTCATGAAGAAGTTCAGACT GAAGGACTTCTAGATGTGAGGAGATTACAATCAGGTAATAAAATATAGTACAGTTGACACTTGGCACA CATAGAAATGCCACAGAAATATGGAAAAAA AGGAAAATATGATTGCCTTTGGGTGTTAACCTGTTGGC TTATTCACATATGGACCAAAGCAGAGTTTGTTATAAGTCACTTAAAAAAAAGAGAAATGGCTTCCAGG CCTGCAAGATATAATGGAAGCCTGACATTTCTAAAGAAAAGGGCTAGTCATCAATGAAAACACTGGAT AAAATCAGACTAGGAAAGTCTGGCTGTAACTTCCTAGGG GATATTTGCCCAAAAGCTTCAACATACTC TCATTCCCGTCAATGATGCTTCACGGAAGTTGAATGTATCAGGTATCAATTGTCCAGTTCTTTCAGTTC CTGTTCTGTCACTTCCCTTTGTCTAGATTTCAAGCTTCCTAAGAAGCTTCTGTTATGTGGGGACCCTGT GTGTCTTCTTACAGGGAAAAAATGCTCTGGTCACCTGCATACC AGTCCTTTCCAGCATTCCAGTCCCT CTGATGGGTACTTTTCAATTTAAATCAATAAACTGGCATTCCGATTTTATAATTCCATCTCTTGAGTTTG TTAAATGTGAGTTTGATTGGTGGGCTGGCTTAAATCAGTTTCTAAGCCTGCAATCATGAGGGCCAGAC CTGAACTCTAGTCAACTCACCAAGTTTGGCTCGTTTGTTCATTT GTGTGGCAAATGCGATTGGTGCCC TGGATCTTCCTACTGTATTGTATGCCAGTCCTAGTTTCAATTGCCAGCTCCTGCATTTCTTGCTTAGGG CTCTCTCTGACCAGCTGGAGCTGCTGTGTCCCAACCACAGCAAGCCAGCCAGATGAGGATAACAACA TTATACACTCACAGGATAATTGTGAAGTGTGTGTTCTAC ACTGGCTCCCAGAGTTCTTCAACATAAGC AAATTCCAGTTGCCCAAAGTGGACACTTGATTGATAATACACCCTTTTTGGTTTCCTCCCTTCCGTAAC TCACTTACTTTCTTACCAGTGTTTCTAGGGATCACCTCCCAAATAAATTACTTGCACTGAAATCATTGT CTCAAGGTCTGTTTTCGTGAGAAACACAAACTAAGACAACTTCGTCCATTCAT TCATCATTTATTGAGC TTAATCAATTATTAATAAGTCCTTAAGGCACAAAATAAGTCCTTAGCAACATGTTATCTCTTTTCTCATC ACAGTATTATCCCCTTTACAAATGAAGAAATCAAGGTTGAAATAAATTAAGTAGCTGACTCAGTATCAC ATAATCAGGACAGAGTGCTGGAAAGGACTGATGGCAGATGAAGATGGCTGAGACTCCCAGATGCC C AGTCTTGAATGGAGAGTATAAAAAATGAGTTTTCTGCTGGGGTAATAATTTGAGTATATTATAAGATTG CTACGAAGCAATGAAAAAAGGGATTATTGAATGAGGAAACATTTCAATGAAATATATTTTGAAATTTTTGTTTCTAGGAAAGCAACATGCTACAATAAGAGCGCACACATACACCTGTGGGTTTAAATCCTAGC ACTACTAG TTTTTAGCTGTAAGACATGGGCAAGTTGCTTACTTACTCTAAGCTCAATTTTCTAATCCAT encenn / Lznz / B / YiAi AAAGTATATAATATCCAAGAATGTTGTATGAATTAATGAGATTTATTTAAACAACTGGCACCTAATGAGT GTACAAATTTAATTTGCAGAAATGTACTGTCCTTTCAGGAACTTTGTGGTAAGTACTGAAATATGGATG CAATCAGTACTATGCTTAGCAGTAACTTAAAAAAAGAAGCAATATAAAATTTGTATGTCATAAATGATAA CTATATT ACTATCTTTAAAAATCTTGGTCTTTCCATATGTAGTATGCTAATTTAATGTTACAAATAAAAG TAAAATCAATAATTTTAAAAAAGTCAGACTTTAAGTATAAAATTTTGTTTGAAGCAATGCCAAAGAATCCA CATAGTAACATTTACATTTTGATAACAGAATTTTGTGTTCTGTATGTGGGCCTCAAGCAGTACTAAAA CAAAATAGTGTATC AATTATAAATGATACTCATGATTCTTCCCTAGTCAGATGTTTTTTTCAGTTGAGAG ATTCTGAAGAAAAACAATAAGTGTAGAATGTCTGTACCATCTTTAATACTAAGATTTAATTGAATCAATG CATTTCCTTAGATTTAAAAAATCATTTTGTTAGAGTCTGTGTTAGAATCAGTATGATACGTATTTAAAATG GAATTAGAGATATGGACTGTAGTA GGAATGACTTCAAATAACTCAAATGATGCGCATGTCAGAAAGAA ACAATTTCTAAGGGCTGCTTCATTGATTCAAGTGGAACTGTTTTATTCAGAACAGCTCAGATTAGCAG CAGCAGCAGCTGGTGTTCAATGAAATGCTTCCCTTTTCCACCTACTCTCCAGCTGGGTTAAGACAGG CACAAAGAGATTGGGATGACCAAGGTCAAAGCATG ATTTGATAGACTTCCAGGTTTTTGCTCCAGTAA CTTCTTGTGTAGTCTTGGCTATAGAGGCAATTCGTGAAATTGGTGGTTGAAAAAGTCATAGCTTTAGA AGGACTTCATAGATCATCTTGTTCAATATCTTAATTTTATACTTCATATACCACGGTTCTAATTAAATA CTTTATTGTTGCATATTTATTGGAATTGACAAGAAGTTAAGAT TTCTTACATTTATTTCATTTGCCTGATT TTTCTGTTCCCACTGAATTGTATAAGCAGGCACTACTGCACTTTGTATCTCCTACTTGACATAGCTGAAA AATGAAACATTCAAAGATACACTACTTTATTACATGTTAGCTCAGTAAAGGGGCCCTCTATTAGACATG CTGGTCTCAGTTCTTAACTTTTACACTCACAAAGCCCGATTCACTCATTCAAACCTT TTTTGAGGAGTT ACCAGGTTTTAGCCATTGAGATAGATACTGGGAACACAAGAAGTCAAGGGTGCTTCCCTCTCTCAAG AAGCTTAAGAGAGACAGAAGTGCTAAGCACATACATCGAGTATGCGGAGGGCACACAGAGGTATAA GCAATGACCCTCCTTGAGTAGATCTGAAAGGCTTCTCAGAGGAGGAGCTTGAACTTGTCTAAAAG GT AGAATAAACTGCATGCAAAAGAGCTCCAAATGACTCTCAAGCTTAAGTATTGCCTAAGCAATACATTC ATGTGGGAAGTGGGAGATGGGGCTGGAATGGAGGCAGAGGCCACATCCAATGGGCCGTTTTTGGAG TTTAGACATTATTCAGAAGGCCATGGTGAGCCACTGATAGAGTTAAGAAAGGCAGCAAGGTGATA AC ACATGTTTCTTAAGAAAACATACTGTGATGAGGACATTTGGCAGGAAAGTAGTATAATATGAACCAGC ATTCTCTGAATGTTGGGGTTAAAATAGTGAATGAGGTAATATGATCTTACCCTTCTGGAACTTACAGTC TAGTTCAGAAACACAACGGTCTAAACACTAAGGGTCTAAATTAAGGTAGTAGCAGTGGAAAT ATACA GAAGGAAATGGATGTTATGATAATGATGATGATGATATTGCTTATTACCATTTATTGAACACCTCCAT GTGTCAGGCACTAAACACCCTCATATGCACTATCTTTGTCCATTCTCCACACAGTAGCTAGAGTTATTCT ATGGATCTTGTCATAACTCTCTCAAACCCTTCCAGAGGCTTCCCACCCTCATTCAGCACAAATACCTAA GTTCTTAGGAAAAGCT AAAAAGTCCTCCAGGCTGTGACCCACTGTGACTTCTCTGAGCTCATCTTCAA CTCCTCCTTTCTCTCCTTAGCCACAACGCCTTGCTACTGTTCCTAGATGACTCTAGGCACCTTTCTGC TTCAGGGCCCCCTCTGTCTAGAAGGTTGTTTCCTTTGTATTTCCACAGTTCATTCCTCACTTCTGTCAA GCCTCTGATTAAACGAATTCTTTTCAATAA GATCTTCCCTGGCCACTCGGCATGACGGAACTCCTGTA GCACTCCCTATTCCCTTTGCCTTGCTTTGTATTTCTCCTTAACATATCATATTCTGACATAACACATATG TGTTGGTTTTCTTCCTCCATGGATCACAAACTCCATGAAGGTAGACTGTTTTTGTTCATTGCTGTATTC TCAGCACTGATAACAGTGCTCGCACATATCCATTCAATAAATATG TACTGAATAGATGAATGAAGGATT encenn / Lznz / B / YiAi ACAATGGTCCTATGAGGATGGTACTATTATTTTTCCCACTTTCCTAAAGAGGAAACAGACACCAATTG AGGTACTCAAGGTTGTATTTCTGGTAACTGGCAGAACTGGGATTTGCGTGGGGCGGGGGGAAGCCT GCCTTTGTTGAGTTGTACTATGTGCCCAGCATTATTCTAAGAACTTTATGTACATTAACACTTAATCC C TACACCTCCATTTTATAGATGAGGAAACTAAATCAGAAAGGGGTTTACAATCTTGCCTGGTATCTGTG CACTTGCCAGTAAGTTGGGGGCCTGTGCTCTCAGCTACTTTGCTACACTAATTCTAAAGCCAATTCTT TAGAGAGATACAACTTTGCCTCTTAATTGCCAGGAGAGTGAGGGAAAGGAAGAAATCCAGGATTGCT ACCAT TATTATGACTGTGGACCGCCATAGATGGTAGAGTCACCAATCAAGTCAAAGAATGTAAGATGA GTTGGTTTCATTCTCCTCTAACTCTAGACTTCCACATCCAACTGCCTCCTGATATCTTTGCTTGGATAT TAAGACACAAGGTCAGCTGCAGTTAAAGGGATTTAGAATAACCATGGCAGATCATAGAAGTTAGTAGC TGTCTTACATCAGAGTTGA CCTGGTACACAGGACCTGCCCAATGAAGTCCTCAGGGCCCCAACTTGT TGCTCTGCAATCCCTAGAATGTTTCCCAGTGTCTTAGTCTTGTTTATGCTGCTGTAACAAATACCTGA AACTGGGAAATTTGTGAAGAACGAAATATACTTTTTCACAGTTCTAAAGGCTGGGAAGTACAAGCTC AAGACCCCCAGCAGGTTTAGT GTCTGGTGAGGGCTGCAGTTTCCAAGGTGGGACCTTACTGCTATAT CCTCTGGAGGGGGTGAATGCTGTGTCCTCGTGTGGCTAAAGGGATGGAAGGGCAAAAGAAGGCCTA AGCTAGTTCCCTCCAGTCCTTTTACAAGGTATTAATCCATCCATGAGGCAGGGCCTCCATGATTTCAT CAGCTGTTAGTATCAT CACAATGGGGATTAAGTTTCAACATGAATTTTGAAGGGGACACCATCATTGA AACCACAGCATCTTTTCAACATGGTTTACTACCCCAACTATTTAATACATACATTCATCAGAAAAGGACA AAAGAAAGGGCAAGTGACACCCAATTTCTTTTAGAAAATGATCTGGAAGTTGCATACATAATTTCTGCT CACATCCTACTGGCCAGAACTTAAGAGATATG GCCACACTTAAGGGTGTATTATAGGCAACCATGTGT CTGGCTAGATGTTCTATTATCATGGATAAAGAGCAGAATGCATAAGAGTCAGCTAGGAAGCAGTTTGT ACAACAGATATCCAACAGGTATCTCAAATTTAACATTACCAAAACTAAATTCCTGCTTGTTCTCCCAAA ACCTGCTCCTTTGCACTGTTATCACATCTCAGTCCATGGT GGAAGACAGAACAAACTCAGGGGTTTGA TGTTAATCATGTTGAGCTTGAGGTGCCTGTAGAACACCCAGTACAGGTTTCCAATAAGGGGTTGAAGA TACTGTGTCTGATGCTTCTGACTGAGATCTGTGTTCAAGATTCAGACTTGATTCCTGACTGAAATAAGT GATAGAAGAGTATACGTAAATGGTACTGTCAAAGATTATAAC ATGGTAGGCAGAGAACCAAGAATGG GGAGGGAGGATTCTGCACAGGAGACCTGAGAAAGAGTGGCCTAAGACAAGGCAGAAGAGCAGAGAA TGTAAGGTGACAGAACCAAGGGAGCAGTTTCCAGGAGGCAGTGGTCAGCAGTGTGGAAGGCTGCAG AGAGATCAGATGTTATGAAAACTGAGAAGCAACCTTTCAATTTG GCCATTATGCCACAGTGAAATTGATACAAGCAATGTATACAGTAAAATGGAGGGAGCTGCTAAATTTCTGTAGTTGAAGAGGAATTTGGAAG GTAATAGCAATCTAAGTATAGACAGCTTTTCTAAATAGAAGGGACAAAGTAGAGGGAGAATTTATGAA CAGGAGTGGGAATATTTAAGGGAGTAAGAGTCTTGAGTCAATCTCTCTTCCCTCA AGAAATAAAAATT ACCTGTAGAAAGGACAGAAGGATGGCTTCTACCTTAAGACTCGAGGTCAGAAAGAATGCAAATTTAG ACAGGTCTGCAGGCATAAGGGTGGGGGTATGTAGGAGTTCATGCCTGATGTGTGCAGTACTAAACAA TGATACATATACTACTACTACCACTACTAAGCACTAACATTTACTGAGCACTTATCATATG CCAGT GTTCTTCATGGAGCTAAGTTTGCTTAACAGTATTTCTTAAATAATGGGAGCTATTCATATATTGAAAGC TTAGTGTTTTTCAGAAGTTGAGTGTGTAACATTTGGATGTGGCCTAAAAATAGCAACCGTGACTTCTAT CCCACCATATCTGAATTTTGTCTCTTCCATGCTCGACTTATTTCTGATCCTGGGGCATGCTGAG TAGT AAAAAAAAGTTGTTCTTGCATTTTGATTCATCTGTTATGACTGGCATCAATAAGAAATCTTCAGCAATAAA encenn / Lznz / B / YiAi ACAGCTCTGTCAAAAAACAACTTCACCAGCAATTTAGGGCAAAATGTTTCCTTTTAAAAAAAAGTTTGTT GGCTGGGCATGGTGGATCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACG AGGTCAGGAGATCGAGCCCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAA TT AGCCAGGCGTGGTGGCGGGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGG CATGAACCTGGGAGGTGGAGCTTGCAATGAGCCAAGATTGCGCCACTGCACTCCAGCATGGGCGAC GGAGCAAGACTCTGTCTCAAAAAAATAATAATAATAAAATAAAAAAGTTTGTTAGTATTAGCAGATA CATATTACTAG GTACCCCCCATGCTCAATGAAGTGTTGGGTTACTCTGAAAAAGTGTCCAATCTTACA GGTGTGACTTCCTCTGGAACTGCAAGTTCTTGAGGGCAGGGATAGAGATTGTTCATCTTTTATTGTTT CCCAAGGTCTGGCACATAAATAGTAGTTCAAGTAGTCCAACATATGACACATAAATAGTTCTGGGTAA ACATTAGCTCAAAG TTTGCTCAAGGCATTGATGCAGATGCTTATAAAATTAAATTGCTCTTTTTACTGT ATACCTGAAATGAGAAAATTATTAGAAACTACTGGGTCTCATTTGGACTAGAAAAGTCTGAAGAAATCA CTGTTCACTTAGTAGATACAAAGTTGTTTTTCTGGGAAAAAACACACCTAAAAAAAAAAAACACATGGG TCTGATATGGGAGAATTTT TTTATTTTTCATATAAACAGGTGTATAGGGAAGTGGAACACTGCTAGTAT CTTAAGGATTCCTGAAAGTATTTATGTTGGTAAGTTTGATGAGCAAACATTTCTAAATTTGAAAATGGA TAAAACAAAAAGCACAGTGAAATCTTGAAAGAATTCTAATAACTAATGTCACACATAAGAATACAGATTT AAAATTAATGAACTAAAACGGATATACGTAAT TTCTCCAGGAGGAATTAAGATCCTCCTTGATCTCAGT AAAGCAATGAATAGTCATTCTGACATCTAGCTAAAAGCAGACTTATTTCCCTTCGGTCTTTAATCTTTTT GGAACTCAGGGATTTCCGCCACACTTTGATACACCAGGCCATTATAAAATTACACTTAATTTATTGTCAATTTCTTAAAAGGAAGAATACCTATAAGTATCTCCATATGCTAGATATAG TAGAAATGGTATGCTT TAATTAGTCCAACAATAAAGTCCTTAAAGATTTACATTCTTTGTTGCCTATTTTGAAAACTTGCGAAGAT AAATTTTTTTAAAGATTATAATTCTTACTAGTCCTTTCCATGAAATATAACAGCAAATAGTTTCCAAATGT GGATGTGTAATGAGAGGAAATGAAAAGTGAGTAAAGAGCTGAGTTAAAACATCTTAAAATCGA ATATG GCTTAATACTATCATTATCATCAGTTGTCCTGGAATAACTTAAATTCTCTAGCTTATTGTTGGTTTTTC AATGGTTGGTTATAGTTGTGAGGCGGATACACACACACACCCACACACTTGGCTATACAAAAAAGATG TTCCGAGACTGACAGTTAAAAATTACACTGCTGGCCGAGCACTGTGGCTCATGCCTGTAGTCCCAAA ACT TTGGGAGGCCGAGGTGGGAGGATCACTTGAGGCCAGGAGCTCGAGACCAGCCTGGGCCTAAC ATAGCAAGACACCATTTCTAAGTTTAAAAATAAAAATAAATTTAAAAAAGATACACTGCTATGTACGACT GTTGATATAAAAAATCTGAATACTAGACATGGGTACTCATCTAGTACTTCAAGGGCTTATCAACAAAGT TGCAAGTTGTAAC ACTATGAATTGTTAGTGATACTCTTTGGGCTTTGCTAGCAAGTGTTGTAAAGCTAT ACACACACACACACACACACACACACATACACACACACACCTTTTAAAATGGTGACCCTGGTACCAAA TATGACTTTAAATGGATTTAATTTTAATGGCTTTAACTACGTTCAGCTGTCATATGGATCAAAATTAGCC TCTATCCAGCTGGGGTCAACCAG GGAGCCACTTTTCTTAACCGACGACCTACTGAACGTCAACAACT GCAGGAGACGGGACTTTACCTTCGTCTCTGGTAAACTAGTTGACACATCCTGTGTTGGCAAGAGGCC TAAGTAGATGACCTTGGTCCTCTAAAATCTGGCCTGCACTCTCGGGGCACCCCTGCAACATCTACAA AGGCAGCTCCAGATAGAAAAGGGTTGGGGTC GAAAAGCCAATAACGGCAGGCACCTGCCCCGCCTC GGGGCTGGGGGGCTATTCCAGCGGCTTCAGCTAACTTTCAGAGCCATTCGTTTCCCAACAAAGTCTG AGGCGTTCCCTGCTGGGTACACCAAGGGGCTCTGCAACCCTCCTGGGGGGGGGGGTGCCCAGAG GGCTTCCGGAAGTCCCAGGTTTATT CTTTCGGGTCACAGACAGCAGAAACTAAAAAGAGGGATTACC encenn / Lznz / B / YiAi CTTTCTGTCCAGTCGCAAGATGGCGACCGAGCCTGGTGGGACTCCGAGGGGCCGCAGGCCACCTC CTTTCCCAATGGCCCGTGCGCCGGCGGCGACGGCAAGCGGGAGGGAGGCGGGGCCGCGAAGG AAGGAGGGGCGGAGCGCGGCGCCCTCCCGCGCGTCTTGGCCCCGCCCCACGTCCCCGTC CCG GCCTGGAGCCCTCGCCCGGCCGGGCGGCGCGCGCTGCCTGCCGGGATACTCGGCCCGCCCAGCC AGTCCTCCCGTCTTGCGCCGCGGCCGCGAGATCCGTGTGTCTCCCAAGATGGTGGCGCTGGGCTC GGGGTGACTACAGGAGACGACGGGGCCTTTTCCCTTCGCCAGGACCCGACACACCAGGCTTCG CTC GCTCGCGCACCCTCCGCCGCGTAGCCATCCGCCAGCGCGGGCGCCCGCCATCCGCCGCCTACTT ACGCTTCACCTCTGCCGACCCGGCGCGCTCGGCTGCGGGCGGCGGCGCCTCCTTCGGCTCCTCCT CGGAATAGCTCGCGGCCTGTAGCCCCTGGCAGGAGGGCCCCTCAGCCCCCCGTGTGGACAGGCA GCGG CGGCTGGCGAACGAACGCCGGGATTTCGGCGGCCCCGGCGCTCCCTTTCCCGGCCTCGTTTT CCGGATAAGGAAGCGCGGGTCCCGCATGAGCCCCGGCGGTGGCGGCAGCGAAAGAGAACGAGGC GGTGGCGGGCGGAGGCGGCGGGCGAGGGCGACTACGACCAGTGAGGCGGCCGCCGCAGCCCAG GCGCG GGGGCGACGACAGGTCAGTGTTGCCGCGGCCTGCGCCAGGCGGCGCTGGCTCCCTCCCG TCACTCGGCCGGCCTTCGGGGCCCGCTGTGGCGAGGTCGACACCCCCCTTCCCCGCCCCCCGCCGCCGAGGCGAGTGTTTGGGGGCGCGTGGTCCGAAGGGGCTGGTGCCAGAAGTAGGCCCCTGGT GGC CGCGGCTGCTGCAGCCGTAACTGTCAGTCCTGGCTGAGCGACGGCGGGAGGGTTTTGTCGCCCGA GGGGACGCGAGCGGGCCCGGGGCGGGGCGGGACGTGCGAGGCGTCGAGATTTGGGCCTCCTAGG AGCCAGGCTCTTCGAGCCAGCCGGGGCCCCAGACAGGGAAGGGCAGGCCCTTTCCTTCA AAGGGG AGCCCTTTCTCGGCGTTTTCAAGGTTTTTGGCTCTCTTGGGGAAGACATATTTAGCCGTGTGCTTGGT GGGTTGGGGTTTTGGGGGTGGATTGATGGGAAGGGAGGGCGGATGAAGTGGTATGTCAAGCCCAA GGGTTGTGCGCACAGGTTACTCTGTGTTACCGGCCACCAGG ATTTCTGAAGTTGAACGTGAGTTATT GGCTTTGCCAGAGACTGCTGTGTTATATGCAGACCTGTATGCAAGCAGTTGGCCTTTTTTCCCCCCC CTTTTCAGTGTAGAAAATGAAAAGGATGCTTTCCTCATCTTGGTGGTAAAGGCTTTTGTTGGTAAAGG TAGAATTGAATGTACCAAATGCCTTAGTCCGTAAAATTTTAGA AATAATTTTAATACAGACACTGGTGA AGCTTGGCAACCTTGAAAGAGAATTTAGCGTCTACATTTTTTAAATGACTTTTTATGGATATGCTAAATT AGTAACAGTCCAAAATCTGTTTGAGATTAAGTGGCGAGGGTGCTGTTGAAAATGTAAACTAATAG CATATGGGGTTTACAGTGCACAGTTAACCTCAATCATGAAGAAATG TGGATATGACCCGTAATTTTGG ATCATTTTACTGCCTGCAATATTGAGAGAAGCAGCAAATTATTACAGTTTTTTTTGGGAGACGACCTAA AGTTTAAGAAATACAACTGTTGAAAGTTACCTGTCAGAGACACAAAGGTACCCAATCAATCTTGTTGAA TAAATTGGACAAGTGGGATAAGGTGTTTGTCTCACACTTCTGATCAATAAGTAC TCTTACTTAAGAAGT GATTTGGTAAATCATGTAAAATTTAGAATTTAGGAGAGATAAGAAAGTTGTAACTTGGTGTGTATAGTG GAAATAGCTTTGAAATTAGATCCTGTTTTTAAATCCAAGCTACTTACCACATTTTAGTGAAATGAATAC ATTATTAATGATGCTACTGATAAGCCCTAAGGATGACCAGAAGCCCTTTTAAGAAACACTAATACAG TT GACCAAAAAATAAAAAAGGAAATAGCTTCAAGAAATAATTTTCAATCTTTGTGTATTTATAATATACACA GGAGAAATAAAAGAACAGAATATGAAGAGGTAACTTATAATCTTTACAAATTAGAATGTAAACTATGC TAGTCTTACTGTGTCAATATTTATTAACCTGCATTAGTTTGCTAAGTAGTATGCTCACTATCCTCTGGA CATTGCCCCTG TCCCTGAGGAGCTTAACTTTATACAGAGATACAAAATACTGTGTTTTGATTTCCTTTTC AGAGGATTTATAAGCTACTTATGTTTTATCTGTCCTAAATTCTGCCCTTTTTTTTCCCATGGCTGAAAAA encenn / Lznz / B / YiAi ATAACTTCCTAAGAAAGGTACATACTAGTCAGAGGTGTGGGGAAAACGTGTTCTCATCCCACTTGTGC AGTCCATTTAACAGGATTTATTGGGTACCTACAGTGTCTTTGACATGTAACATTTAATCAGTTGTATTT CTTAAACTTTAGATAATTCTATTTCGATCATTTCTATTTCAATCTCCTCCCTCTCCCCTCCAAAAAAAT TTACTG TGTAAACTGTGATAATACACTGTTTCTCTCAGTGTCAGTCAGTGGAATGATCCAGATTTATAG GTCATAGCAAAATTTTCATCCCAAGCTCTTGAAATGATGTTTCCAAATGTCCATTTTCTTAAATGACTG CTAGTTATGTTCTCCAATCATGTTACACATATTTTGTTTAGACTTATAATTGTGTAGGTCTAAATGTAGA AACATTACATT ATGTACATATGCAGCTGCTGAAAGAAAATTAGTTTTCTAATTTTTAGATCGGGGTGAA GACAAACTTTTAGAAGTGATCTTTCGGTAAAATACTGGATGAAGTCTTAGGTGCTCTTTTTATGTTGGT TCAGGACAAAAGTTTTTTGACTGCTTTTTGAGTTTTCCCCTCACTGCCAAATGTAAGGATAAAATGTAG TAACAAGACTCTTGG TATGTATAGTGGTAATATCTTTGGAATTAGACCCTAATTTTAATTCTGGCCTT ATTAATCTTGGTAAGCCACAGTTTTGTCATCTGTAAAATGGGTTGGTGAAACTTCCCCAGAGTTGTGA GGCTTAAAGTATGTAAAACGCCTAACACGTAGGCACTCAATAAGTATTACCTTAGAAATCTTCCTATCC AGTTTTTCTGAATGGTCT GGAAGCACCTTGTATGTAGTGGACTACAGCATGTTATCCTTTATGTTGTTT ATTTCTTTTCTCATTAGCTATGAACTTTTTAAGGCCAGGAATTCCTAGTGTTTACCAGAGAATGTGTTA CTAGATGTCTTAGTCTGTTCTGGCTGCTATTACAAACACCACAGACAGCATGGCTTATAAACAACAG AAGTTTATTTCTCACGGTTCT GGGGGCTGAGAAGTCCAAGATCAAGGTACCAACAAATTTGACATCTT AGTGAGGGCCCTCTTCCCTTGTTCATAGATAGCTAGCTGTCTTTTCACCATTACCTCATGTAGTAGAA GAGTAGACGGGGCTCTATAGGGCCTCTTTTATAGAGGCATTAATTCCATTAATGATGGCAAAGCTTCC CAAAGGCCCCACCTCTTAATACTATCACCTT GGAGGTTAGGCTTTCAACATGAATTTTGGGGGACACA TTCAGACCACAGCACTAGAGCAGGCATGAATTGGTTATTGGTAAATCAGTAAATGATCAACTAACATT TATTAGGTTCCTCCTGTGGCTTCTATGAGCTGAGCTAAGTACAGGACCCACAAAGACAAGAAAGATGT CTGTCTTTTTTGAATGCTTATAGTTGAGTG ACTTTCTCACATTTGTGTGTGTGTGTGTGTGTGTGTGTG TGTAAAACCCTATCACATAATGGAACTTCATTTTCCCATGCCCTTCCAATCTAAGAGCAGTTCTATGGA CTCAATACCTCCTACCCACAGCTGCTACTGTAAAGATTTACTTTTTTTACTCCTTTTAAAAAGTTCAAC CCTCTGGCACATGCATTACTTCATTCCTTG GTCCCAGCCCACCACCCCAGTATCTGGCACGTAGTGT ATTAGTATTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTATAT AGAATTTAAAATTTTTACTCCGGCAGTTGTCTTCAAATACTCTAATTTTGGGGGGCATGATTATC ATTC TGTCTTCTGGCAGTACATGGATAGATGCTACCTGAGTAGGATTGTCTATGAGGTCAGCTGCTCCAGT CATTTTATACAAGAGGAAATTGGAGTGCAAAGCTTTAAAATGATTTTCTTAAAGTCACCCAGGTGTCAG AACCAGAACCAGAGTCCATGTCTCTAGTTCAGGACTCTGCACACATTGGCACATGTTCTGTCCTACCT TTTGGGATGAATAGTTATACTTGCTTTGTGATTACTCACCCACCTTTTTGGAGACATATGAGTGTTTTG TACACTATTAATAGAAGGCAGCCTTTCACAAAATGCCATCTGCAGATCTGTTATTTCTTCTAATAAAGGA AATGATGTAAAATTACCTTAAATAGAAATAGTGTTAATTCTTCTGGAGACATATTCCATAATCCAAACAC GAAATGTTTGA AATACTTGAAGATGCCATATAAATAAGTCCTTTGTAAAAAGATAATATTAAAAATTTTT GTTTTATAGAGATGGGGGTCTCACTGTGTTGCCCAGGCTGGTCTTGAACTCCTCAGCTTTTACTTTAG CTTCCCAGTGTGTTGGGATTACAGGCATGAGCCACAATACCTGGCCAAGTCCTTTTTTTTAATCAAAT GACTTATTAATACACAGTTTC TTTGCCAGCTTTTGTTTTCATTTGCTATCAAAAATGTTGCTTAGTAGTG CTTTGATCTGAGTTATCAATAACAGGTAAATGCCATTATGGATAATAATTCAAAAAGAAGCTTATTAATT encenn / Lznz / B / YiAi ATTAGGCCTATCTGAGAGTGAAGTAAAGTTAGCATTTTCTTTTTGTTTATTTTACTTATTGTTTATTTGTT TAGAGACAGGGTCTCGCTGTGTTGCCCAAGTTGGAGTGCAGTGGTGCTGTCATAACTCATTGCAGTC TCAGGCTGGAGTGATCCTCCCATCTCACCCTCCTGAGTAGGTGGGATTAGCATATGCCACCAT GCCT GGCTAATTTTTTATTTTTAATTTTTTGTGGAGATGGGGTCTTGCCGTGTTCAGGTTGGTTTCAAACT CCTGGTTCTCAAGCGGCTTGGCCTCCCAAGGTGCTAGGATTACAGGTGTGAGCTACCATGCCCAGCT GAGCATTTTTAAAAAATACTGGTCTTTGTACATGAGTCGTTACTATTTGATTCTAAGCC TTATGACTGAT ATCCCTAAAAATTATTTATAAAATTTTAAGTGCATCAGAGTCATTGAAATGGAATGAGCACTGTCTTTTG GTCTTGAGGTTGTTTTAACTAGCTTCGTAATGGTCATGAGCAGGTTATTTAGCTTTGAAGCCTTCGTT CCTTCTTTTGTCAAATGAAAGTGATAGTTGCTTTGTTTTAAAAGAGTATGCTTTTCAAACGTGA TCATTC TTGAAAATGTAGATTAAGAGCTTTTTAGAGGCCAAGTGCCATGGCTCACGCCTGTCATCCCAGCACTT TGGGAAGCCGAGGCGGGCGGATCACGAGATCAGGAGATCGAGACCATCCTGGCCAACACGGTGAA ACTCATCTCTACTAAAATACAAAAAAAAAATTAGCCGGACGTGGTGGCGCATGCCTGTAGTCCCA AC TACTCAGGAGGCTGAGGCAGGGGAAACGCTTGAACACGGGAGGCGGAGGTTGCAGTGAGCCAAGA TCATGCTACTGCCTGGCGACAGAGTGAGACTGCCTCTCAAAAAAAAAAAAAAACTTTTTAGAAACG TTGTTTTGGGGAATTTTTAGTGTGTGAATTCATTTTAAATATGTGAACTCCATTTGACATGGACAATG G ATCTTAATAGTTTGTGATACATTATTCAGTGTATTAATCAAAAGTCAAATCTCTTTGTAATTTGCTGTA CCAGACCTGTTGTGTTAATCTGATCAATGGCAAGTGAATCATAAGATTGACCTGAAAGGAAAAGATAT TTTTAGGGGACATAGAATCATATTGGATAAGATTATTCCTATAGTTCATTTTCAGGAAATCTGAACAGG AAT CTCGTGTAAGGAATCACATGTGAATTATAGAAGAGAGTCTGATGTAAGACTTTATTTATTAAGGTC TGCATCTGTGTTTCAAGTAAGAGCATAGAGGTAGTATATGAGCCCTGAACACTCATACAAGTAGGATA AAATTTTCTTAAAACTGTTGGCTGGACAGTGTAGAGTCTAATGCTGTGACTCTTAACAGTTTTGTGTG TTCCA GAAGTTCATCTCCTCAGGATCAATTGAGGTTAGTCTAGCACAGACTTTAGTTATAGAAACCAAA CATGAGAAAAAATTTTTTGACCCATGTCTTCGTAGCATGCAGGCTTGGTAGCTCTTTCCTAGTTCTGGA TGTGTGCCCGTTGTATATACTTTCAGCAATTCAGGATGTTCCTTTTCATATTTAAGACAAGCACTCTTG CATACAAATTACATA GCTGTGGGCTGAATGAAGATGCTACCATTGCTGTACTTCTACACAGGTTCTTTT CATGTAATGAAATCAGAAGGGATGGCTTTTCCATTTCAAGCTTCTGTTAATAAGTAGTCTTAGAATTGC CTTTGTGTACTGTAGCCAACACCCCAACTCATATATTTTTATAATCTTTGTGATGCAGAATAAATTCTGA AACTTTCCACCTCCTAAT TAAATATAGAAATACTGAAAACAATAAAGCACCATGTATTCACTATGGACA TATGTCACATTTTGTCACTTTCTTGCACTCTTGTAATCCCTCTCTAAAGCTCATGTTAAACTCATGTTCT TTATTTTCTTCTCAGATGATTCCTTTGGCACTGCATGTAACAGTACAGGAATTCTTCCTTTCGTACTTC CAACAAATACTTTTTGTCTCTTAACAGATG TGAACCATAATGCTGTTCTTTAGAAAGCAAAGGATGAA GTGCACAGCAGTGTTTTCTATATAAAGCTAATGGGTCATAAGGGGAAATATGGGTTATTTCCAGCTTG TTAATTGTCTTAATACATTTTTCCTAAGAATTCTATTGTGCCTCTGTGGTTATATGCACCAATATTGATA ATCTTACAGCGTGCCATAAATAAGGATTTTTATA TTATCTTTGCTAAATATTTTAAGTTTTTGTTTTGGG AATTGAAAAAATCTTTTGTGCATCTATGGTATGTGATACGTATACTAATGGATAAATCCTGTTTCACAC AAAGATTAATTGGGTAACATTTTCTTTCCTAGTTTTCTGAAGTCAGTGGTCATGTTGTGTGTTGGTGA TTGAAAATATGCTGTTTAGGCTGGG CGCCTTGGCTCACTCCTGTAATCCCAGCACTTTGGGAGGCCG AGGCACACGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCT on / ίζηζ / Β / γίΛΐ CTACTAAAAATACAAAAATTAGCTAGGCGTGGTGGCACACGTCTGTAATCCCAGTTACTTGGGAGGCT GAGGCACGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCACACCATTGCAC TCCAGCCTGGGCAAGCAAGATTTCATTCCAAAAAGAAAAGAAAAAGAAAAGAAAATATGCTGTTTAAG ATC ATTCAAATTCAGTTTCTAAGAAGTGTAAAGTTTTCCTAATTACTTAAGCTGCTTCATTTCCATTCCC TTTTGTAACACATTTTGCCATCTCTGTAACATGTTGAACATGTTTAAAGAACAGAGTGGGAGAATAGGA AGTTACGTGGATAAAGTTTGGTAATCAAGGTAGGAATACATCCTGCTTCACAGAATGGGAATATTTCT GAAAAGTTG ACTGTAGTATTGAAGAACACTTAAGTGTAGTGTATTAGACGAACTGAGCTAATTTTGGT CTTTTATACACATAAATCAAGATTTCTGCATTTCAAATCATGCATATTTCTTTAAATTTATTGCTCAGTGT ACTGTATTTCAAATATTGTAAAAATGAAAAGATCTTGTGGTCTTATTTAACTCAGTATGGGATAAGTCCT TCCCACCTTCCCAT TCTTATTCCCTCTTTTAGGCTGAATGAAAGGCTGGGGGAGTGAATTTAAAAATA GATGGATCTCAGCTGGAGAATGGGTTGGTCACGTATCTCAACTGATATTAAATAATTTCTTAAATCCTG GATTGAAGATTATAAGAAAACAGTAAATGTTTGCTCTCAGTTCATTCTTTGTTTTGTTTTTTCATGTAC AGTTTTAGGCACTTGTA ACTGCTGGATGCATGAACTACTTTCTAGTTCTTTCAGGCCTACTTTTAGATA TCTGCTGTGGGGACAGTCCTCAACACTTAAAGTAATTTTAAATAGTGATAGGCAGAACTAGGGGTCAG TTTTACTGCCTATGCCTGTGCTGAATTTGACATGGCATTCCTAGGAGGGGAGGTGGAACGAGGGCGG TGCACACATTGTCC ATATTGCTAGTCAGTGCCAGATTTTGAGAAACTGGGGCTAATCTCTCTCTTAAAT GGTCAAGATCTAATTCCCCAAAGTGCTGTTTCAGATAACCTAGTATTTGTCCAAAATTGCCCTGCTACA ATAGTATTTATCTTATATATATGTATTATATATATAATATATATATAATCTTATATATATGTATTATATATAT TATATATATAATCTTATATATGTATT ATATATATAATATATATATAATCTTATATATATGTATTATATATATATATATATATATAATCTTATATATATGTATTATATATATAATATATATATAATCTTATATATATATGTATTATATAT ATAATATATATATATAATCTTATATATATAATCTTATATATATAATCTTATATATATGTATTATATATATATAATACATATAAATATATATATATATATATATATAGGTTTT TTTTGTTTTTCCTCCTGAGATGTA GTCTCGCCCTGTTGCCCAGGCTGGTGTGCAATGGTGCAGTCTTAGCTCACTGCAGCCTCCGCCTCCT GGGTTCAAGTGATTTCCCTGCCTCAGCCTCCTGAGTAGCAGAGACTACAGGTGTGCACTACCACGCC CGGCTAATTTTTGTATTTTTAGTAGATACAGGGTTTCACCATG TTGGCCATGCTGGTTTCAAACTCCTA ACCTCAGGTGATCTGCCTGCCTCAACCTCTGAAAGCACTGGGATTACAGGCATGAGCCACCACACCA ATCCTATTACATTCTTAAAAAAATGTTTGTTTGTTTGTTTTGTAGAGATGAAGTTTCACTATATTACCC AGCCTGGTCTTGACTCCTGGGCTCAAGTGATCCTCCTGCCTT GGCGTCCCAAAGTGCTGGGATTATA GACATGAGCCACTGCGTCCAGCCTGTATCATATTTTTATTCTGATATCTTTTGTAATTTTGTTTTTAGTGTG AAGTAGGGAGGTTTATATTAGATAATCTTCCAAGGTAATTATCAGCTTGGACATTATATGCTAATATGT CTTTTGTTTGTTTTTAAAATAAGTGTATATGTTTTAATTGTAAAATTT TTAAAACATCCAGAAAATGACAT AGCAAGTGCCTATTTATCCACCACCTGGAAATATAAATTATGTCCATTTTTATCCCTTGGGGGGAAAGG ATGCAGTTATATAATCACTTTTAACAACCCCAACTGTTCAAGTCCTGTTACCCGTCTCTACAAAAGTA ACAACTGTCTTGAGATTCTTAAGTAAATTTCACATCCTTGTTTTATACTTTTACTATACATGT GTACATG TATCTGTAAGTGATATGTGGTGTTGGTTTTTGTATTAAATTTTACAGACATGTATAACGCTGTCTTTCA ATAGCTTGATTTTTTTAAACTCAGTATCAAGTTTTGAGGTGTATATGTTGATGCGTGTACATGTAGTTT ATTCAGTTTCACTGCTGTATGGCACTTCATTTTATGCATAGATAAAATG TATGTGTCCCACTATTGATG GATATTTTGAGTTGTTTTCTTTTTGCTATTATAAATAATGCTGCAGTGTTTATTTTTACATGAGTGTATGT pncrnn / Lznz / B / YiAi GCAGGTGTTTTGGGAAAAACCGTAGAAGTGAAATTGCTGGTTACTAGATATTGGTAAATTCTTTTTCCTA AATGGATATGCCCATGTATACTTTATCAGCATTATGTGGGCATTTCTAGCATCCTCACCCATACTTGG GATTGTCAGATTTTAAAATAGTTACTAATTTGAGGCATGTGAAATGCTATTCTCATTTTAATTTACAG TTG CTTGATTATTCTGAATCGTAGGTAAAAGGATAGGAAATTTATTATTTTCTGTATGTTTTAAATATCTCAA AAATAAATGTTTTTAAAGGAAAGGCACACTATCGTACAACATTTATGTTGAAAAGGACCATGAAGATCA TTTCATCCAACCTTCTTACTTTACAGTGCAGCCAAAGAAAGTTACCAGAATAAGAGTAAAATATAAAAT CCTGCCCATTGTAG TATTCTCTGGTAGTATGAGCCTTAATTTTTGATGTAAAAATCATGTCTTTTTCTTT ATGATTGTGCTTTTTGTTTAAGAAATCCTCTTTTTATATTGTCTGCTAATAGTTGAGGATTTTTTGTTACT CTTTGTTATTTGCATTTAGGTTCATCTGAAAGGAGTTAGGATTTTTTATTTAAATATGAAAAGCTAGTT GTTCCAGCATTAAGTA TTGAATTTTAAATTTTGTATTGAGGTTAAATATATACATACATAATTTACCATCT TTTTTAAGTGTACAGTTCATTTTTAATGATTTTTAAGTGTACAGTTTTTTTAAGTGTACAGTTCAGCAATA ATAAATACAGTTATGTTCTTCGCCTTTGTCCTTCACTCCCCACTTCGGCTGCTAGTAACCACCAGTC TATGCTTATCTTCTTGAGATAT ACTTTTTTAGCCCATGTATGAGTGAGAACATGTGGTATTTGTCTTTCT GTGTTTGGCTTATTTCACTTAACATAATGGCTTCTTGTTCCATCCGTGTTCCTGCAAATTACAGGGTTT TATTCTTATTTTATAGCTGAGTAGTATTCCACTGTGTGTATAAACTACATTTTAAAGTCTATTCGTCCT AATTATTGAATTTCCCCCACCCCAC CCACCTTTTTTTTTTTTTTTTTTTTTCCAGGAGACAGGGTCTCCC TCTCTTCCCCAGGCTGGAGTGCAGTGCCATGATCATAGCTCCCTGCATCCTTGAACCCCCTGGCCTC AAGCGATAGTCTTGCCTCAGCCTCCCAAGTAGCTGGGACTGCAGGCAGGCACCTCCAGGCCCTGCT AAGTTTTGTGGGTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTGTAGAGATGGGGTCTTCCTATGTTGCCCAC TTTGGTTTGTTAGTTTTAGTAGTTTATAATTCCTTTGTATTATTGTGAACAAATAACAGTTATTTTGAAAT AGAAGAGTGCTTTCTATTTAAAATTTTGCTTTGATAGGGTTCTGTCTACTTTCTGAGCCTTACCTTCCT GTGCATTCCCCTTTGGTCAGTACCATCTTA CCACACAGGCTGCTTTTAGTTTCTTGAGTTATCCATCTT CCTTCTATCTTATAGGGCTCAACCTAAATATTACTCAGGGAAGCCTTCCTTGAGAGTCTTTCTTTTTTGC ACTCATTGGTTTGGGGCTTCTTTATATTATACTGTTAATTGAATTCTGAGTCGTGTTTATTCCAACTGAGATTAGGTAATTTATTTTGAGAACAGTAAATGTTTATC ATCTGTCATTCTTTTTTTTCATGCCCACATTCA GTTATTTGTAAGTGCTGAATGTATAAGTGTTCATCTACAGATAAGGATCAGTTCTTTTTTCCCCAACTA GAAATGTTACTCCAGTTGATAATAACAGCTCAAACGGAAATATAAGGCAGAGGTGAGAGAGTCACTTG AGGCCACGAATTGGAGACCAGCCTGGGCAACAAAGTGAGACCTTATCCCTAT GAAAAATAAAATTAG CCCAGCTTGGGAGGCTGAGGTGGGGGGATTGCTTGAACCCTGGAGTTCCAGGCTGCAGTGAGTTGT TATCACACCACTGCACTCCAGCCGCGGTGACAGACCCTGTCCCTTAAAAAAAAAAAATTATAACCAG CCACATTGAAATATTTTGTAAGACATTAATAGAAGACTAAATGTTCTCATATGTTTACTG TTTGTGTTAA GTACGTATGGTTTTTAGAACAACAGTTTTCTATCAAGTGTGGTCTGGTTCACTTAGAATTAGATGGGGT AGATTTTTTGAAAAGCGTTTTGAAGTTAAATTAGAAGCTAATGGTTTTTTGTCACTAAATCAAATTTTGT TTTATGCGTTTAAGTGCTACATTTATTTGATAGGCAGGTGAATGTAACAGATTAAACT TGAAAATAATG TAGCTATGATTCCTTCAAGGAAAAACCCCACCTTAGTTCTTTTAGTATATTGCATTATAAGTCTTTTGTGTGTGCATATATAGCAGGCATAAATTGGCATAATTCTGGGTTTAATTTTAGGCTAGGCGCTATGG AAGTTTGAACTCTAATTACAGTGTAAAAATAACCCAGAGGAAAATTTCAGAATAATAAATCATTGG GAC TATATGGTACAGATGTCCCTGTTTTCAGATTGTAGAATTGTTGACCAGTAGGAATGCTTTATGATTAAA encenn / Lznz / B / YiAi AGCCAGGAAATTAAAGTAATTCTGATGATTTGGTATTTCTAAAGATTTTCATAGATGACAGTTGAGAAC TACTCTCAGATGAGATTCTTCCATTGCTGGTAAGTCATGTAATAAAACACTTAAGTAAATATTTTAATGA GGAATGATAACATTTTAATATTGGCACATTGTGAGTCTACCTTCTGTAGTTAGTAGGTAAATAAGAAAT AAACATACCTTAT TTAAAAAAAAAATTTCAAGAACCCAAGGGAGGGGAGAGCCAAGGTGCACATTAG AAGGAGATTACAGTACTCTTCCAGTGCACAGTGGATGTGTTGTGATTCCAGAGTTCTATGTATGTATG ACTGTGTAGCCCAGATTTACCAGCATGGGCTCAGTTTTAAATGTTAGGTTAGGCTCATAAATCATGAA AAGTTCCTAGGA ATTCTAACATTTTTACATTTCCAGAAGAGAGCCTCTTGTATTTTGTGGTAGTTGCCC CACCATCCCTCAAATATTGGTGTGTAGAATCTATTTTTTGAGGATGAGGAAATACAGAAAAGAAAAAATAA AAAGCTATTTTTTTTTAAGTATAAGAAGAAATGAAAGGTTTCTCTTCGCTTCATAGCCAATTCTAAAACT TAACAGTTGTTAAGTGTG TTTAACTGTAGAGGGAAAAAAAATGCCTGGAAGGAAATTACCAATCAAATAT AAAATGTAAGATAGCTGTAAAAGTACTGATATACATACAGCTTTTTTCCTTTTGGGGAGGCAGTATTTA AAAAAATCCTACCAAACATATTCTCTAACTTTCAAAACTGTTAATAGCTTTATTGAGATAATTCACATA CTATAAAATTCACCCCTTTTAAAGTTTTTAGTATA TTCACAGTTCTGCAGCCATCACCACTATTGAATTTT AGAACATTTTCATCATCCCCAAAATAAATCCTAACCTGTTAGCAGCCATTCCCCATTCTTTTCCTGGCCT CTGGAAACCACTAATCTGCTTTGTCTCTATGAATTTATTTATTCTGGATATTTCATATAAATGGGAATCA TACAGTATGTGTCCTTTTGTGTGTGGGTTCTTTT ACTTACCATGGTATTTTCAAGGTATGTTCATTGAC ATGTATGTCTGTTTTTTTTGGGTAACACACACTCTTGATTACTGTAGCTTTGTAGTAAGTCTTGAAACC AGGAAATGTGAGTATTCTAACTTATTCTTTTTCAAAATTGTTTTGGGTCTCTGGGTTTCTCAAATTTCCA TAGAATTTTAGGGTTAGCTTGCAAAAAAAT GCAACTGGGATTTTAATAGGACTTGGATTTGTGTTGAAT CTGTAGGTCTATTTGGGAAGTATTGCTACCTTAATACTGTCTTCTCATTCATGAGCATGGGATATCTTT CCATTTATTAAGGTGTTCTTTAATTTCTTTCATGTTTTGTAGTTTTCAGTATACAGGTCTTGTACTTATTA CTTTAAAAATTTATTTCTAAGAATTTTATG TTTTGATGGTATTGCAAATTGAATTTTTAAAATTTCATTTC AGGTTTTTAATTCCTTGTGCATAGATTTTTGTGTACTAAAACTTGTGTTTCATATAATTTTTTTTTCCTCT TAACTGTGTTATAGGAATCTTTCAAATGGTTGGCTACATACACATCCATCTGATTCACTTAGTAAACAT TTCTTGAACACCTACTGTGTAGTGGG CCTTTTTTTCTAGGTCCTGGTAGAGACAGCAGTGTATAAAAC CCACTCAGTCCTTTGCTTTCATGGCACTTAAATCCTAAAAAGAGATCATAAAGATAGGTAAAATATATG TTACATAGTGCTAAGGAGAAGAAACAAATAAGGGAAGTGTTTGCAGGTGAAAAGGATGATGGGAAAT TTTAGATAGGGTAGGTAGAGAAAACTTCACTGA AATGGTAACTTGGGTGAAGAACTGAGGGAGATGA GAGAGCTAGCCATGTGGATATTTGGGGGAAGAGCATTTCAGGCAGAGTGTAGTGAATAGGGAAACC CCAAAGTGAGAGTGCCTGATGTGTTTGAAGAACTCGAGGTGTGGCCAGTGTAGCTTTAGAAAAGTAA TTGATGGGAAATAGAGAGAATGGAG GGTACAGATATTTTGATCATAATAAGGTGTTTGATTTTTACCTA TAAGTGAGATGGGAAGCTATTGGAAGTCTTTGAGCAGAGTAGTGAAAAAGTATGACTTATGTTTAGCA AGGTCACTCTGGTTGCTGTGTTAATCATAGACTGAAAAAGGGGACAAGGGCAGAAACAGACCAATTG GTAGACCATTAGTACAGATTAAGACGTGACT GAAATGGACAGAGTGGTCACAGTGAGGGTGGTGAGA AGTGGTTGAATTCTTGATATATGTTGAAATAGAGTCCATAGGATTTGGTAGTAGACCAGATGAAAGTG GGAAATAAAGGGAGGAGTAAAACATGATGCCAAAG1TTTTGACCAGAGCAGCTGAGAGAATGGAGTT GGATAATTCTTATAAATTATTGCATTAAAT CTGTGCATCATATCACATGCCCACTTAACTACAGGTAATT TTACCATATAAGCTTGTGGGGGGAAAAGAGGAAAAACAGAAAAAAGGATGGAAAAGCATGTTTTAAAA encenn / Lznz / B / YiAi TATAATAAATTAGGCCTTAATGAAAAATTGTCCTTGAGAAACCTGAGATGGAATACTCTAAATCTGATG TGTTCTCTCAATCTTTAGAACTGAACTAGGAATTAACTCTGAGAGTTCATGATGTTATGAGACCCTTTG CCTGTTTTGGAAATTCGGTTGTTTTCAATATTTGCTTTGCAATGATGGTACCTGTTATTTTTTCTGTAA GGTAGA TTCCTACAAATAAGATGTCAGGCCATTAGATCATGTCAATCTAAATATTTGATAGGTTTTGCC AATTACCTTTTAAAAAATAATTTTAGCAAGTTTCATTCCTTAAAATATATTAGGGACTGCTCATTTACCTT GTTTTGATTCATGTATATATAAAATCTGTTTAAGTCTTTATAAATAACCTGGGAAATTGCCTGGTTTTTT GGTCCATTTCTATTGTG GTGTTTGTTTTTTAAATTTGTAAGCATTCTTTATATATCATTTAATTCTTTATT ATAATTTGCAAATATTATCTCTACCTACCTTTAATTTTATAGTATCTAGTCATGTGAAATTTTAAAGTTTT TATGTAGGCAAATCTGTCCATCTTTTATGGTTTCTGGGTTTCAGCATGCTAACAAAGTTGATATAAATA TGATCTCATATATATATTACAAAAACT TTTTAGAGATAGGATCTCACTCTGTCACCCGGGCTGGAGCAA CCATAGCTCCCTGCAACCTCAAACTCCTGGGCTCAAGTGATCCTCCTGCCTCAGCTTCCCAAGTAGC TAAGATTATAGACATGTGCCACTATAGCTAGTTGGTTTTTTTTGGTTGGTTGGTTTTTTTTTTTTTTTT GGTAGAGAACGTATCTCAGTGTGTTGCC CAGACTGGTCTCAAACTTCTGGCCTCAAGCTATCCTCCC ACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCTACTATACCTGGCCAATCTCTTGTATTTT CTTCTGATACTTTTGTGATTTTACTTTATAGACTTTAATTTAGAAAGTTAGATATGAGCATTCAGCATAT TTTTGGATATGGTATGATATGGTTTAGATCTGGATT GCATTTGTCATGGTTTGGGAATTATATCTACCT TTTATTTTCTTCC ACTTGG GTAG CTG ATTGTCTTGTAAGG C ATCCTTTCCCC ACTG ATAATG CC ACCTT TTTCTATATTAAGTTCTCACAAACTTTGAAAAAAATCAAGTTTATTGATGTATAATTGATACACAATGAA ATGCACCCATTTTAACTATATAGTTTTATTGATTTTG ATAAATATATACACTATCACTGCTACTACAATC AAGCTTTAGAACAATTGAATTACCTCCAAAAAGTTCCTTCCTGTCTGTAGTCATTCTTCCCTCTCTTGGCC CCAGGCAACCACTGATCTGTTTATTAGTTTTCCTACTCTAGAATTGCATATCCATGGAATCAAGTAACA TGTACTCTTCCATGCCTGGTTTCTTTCACTTGGCATGTTTTTTGAGA TTCATCCAATTTGTGTTTGTCAC AGATTTTTGTTTGTTTCGTTTTTTTAAATACAATATGACTATACCACAGTTCATTCATTTTCTGGTGAAC ATTTAAATTGTTTTCAGTTTTAGGCTGTTGCGAATAAAGGTACTGTTTTGTGTGCATGTTTTGTGTGAA CATATGTTTTCATTTTTCTAGGGTAAATACCTTTAAATTGGA ATTACTGGGTCACATGGTAAGTTTATGTT TAAATGTATAAGGAACTGCCAAACTATTTTCCAGATGATTATACTACTTTACATTCCCATCATCAGTGTA TGAGAGTTCCAGTTCTCCAAATGTCAGCATTTGATGTTCTCAGTCTTTAATTGCACACGTTCTGAGAG GTGTGTAGTGGTATCCCATTGCAGTGTTTTTTTTTAAGTGGTAC TAAAATACACAACATCAAATATACC ATTTTAACTATTTTTAAGTGTACAGTTCAGTGACATAAAGTACATTCACATTATTCTGCAGCCATCACCA CTATCCATCTCTGAAACTTTTTCATCTTCTCAGTCTGAAACCCTATCCATTAAACAGTAACTCTTCATTG CCTACTCTCCCTATCTGCTGGTAATCACTGTTCTACTTCATATGTGAATTTGACTCTTC CAGGTACTTC ATATAAGTGGAATCATACGATTTTTGTCCTTTTGTGTCTGGCACATTTCATTTAATAATAATAATGTCCT TGCGTTAGGCCATTCTTGCGTTGCCTTAAATGAATATCTGAGACTGGGTAATTTAAAAAAAAAGAAG TTTATTTGGCCCCTGGTGCTGCAGGCTGTACAAGCATGGCGCCACCATCTGCTCAGCTT CTGGGGAG CCCTCATGGTGAGTTTACTCATGGTGGAAGGCAAAGGGGGAGCAGGCGTGTCATATGGCGAGAGCA GGAGCAAGAGAGAGGGTGGGGAAGTGGCACACCCTTTTTAAACGACCACATCTGCGAACTCACTCT GTATCCCAAGGAGAGCACCAAGCTATGAGGGGATTGCTCCCATGACCCAGTTACCTCCCACC AGGCC CCACCCCCAACATTGGGGATTATATTTTAACATGAGATTTGGGCAGGACAAATATTCAAACCGTATCA on / Lznz / B / YiAi GTCATCAAAGTTCATTCATGTTGTAGCATGTATCCAAATTTGATTCTTTAAGGTTGAGTAATATTTCATT GTGTGCATATATCACTTTTTGTTTTATTTATTTATTTGTCAGTGGACATTTGGACTCTTTGTAACTTTTAA CTATGTGAATGATGCTGCTATGAACATTGGTATATAAGTATCTGTTTGAGTCCCTTCTTTTAATTCTTT GGTTATGTACTTAGGAGTGGAATTGCTGGGTCATGTGGTAATTGTATGTTTAATTTTTTTAGAGACTGC CATACTGTTTTCCACAGTGACTGCACCATTTTACATTCCCACCAGCAGTGAATAAGGGTTCCAATTTCT CTGCATCTTTTCTAACACTTGGTAATTTCTGTTTTTTATTTAAAATAATTGCCATTCTAATGGGTG TAAA AAGTCATTATGGTCTTAATTTACATTTTCTTCATGACTGCTGTTGAGAAGTTTTCTTTGTGTGTCTGTT CAAATATTTTCACATTCTTTTCAGAACATATGTTCTTTGTCAGATAGATAAATGTATTTCTTCTGTATCCT TACTGATTTTCTGTCCACTTACTAATTACCGAGAGAGGAATGTTGAAATCTTCAACTATAATTTTGAGTT TATCTT CCTTCTGCTCTGTTCATTTTTTCTTCATATGCTTTGAAGCAAAGTCTTTAAAGTTGTGTCCTTA GGTGTGTTCACATTTAGGACTGTTAGATCTCCTTGATTAATTGATGTCTTTATCATTATGAAATGTCTCTGTTTATCGCTGGTAATGTTCCTTATCTAAAGTCTACTTTGATATTAGTGTATCCATTCCTTTCTTATGAT TAATTTTGCA CATTATATCATTTTGCTGTGTTTTTATTTCAGCTTATTGGTCATTTAATGTCTTTCTTT TAGATAGCATATAGTTGCATCTTGCTTTCAGATTGACTTTTTACGATCGTTGCTTTTTGATTAAGTCCAT TTACATTTATTGCAGTTGGCAATATAATTGTGTTTAAGACACTATTTGTTTTCTATTTGTCTAATCTTTTC TTCCTTTTCTGCCTT CTTTTCGGTTAATGGAGCATTTTGGAATTTTGTATTGTCTCCATTATTAGCTTG TCCCTCTGTTTTTTTTCCCCCCAGTGATACTTCTAGGATTTACAATATGCACCTTTAACTTACCTCAATC TACCTTCAAAAATATTATTCCTCTTAATGTATAATGTAAGAATTTTGGAATAGTATACATCCATTTACTCTCCCTCATTCTTTTTGGTATTATGATCTT AACATTTTACTTCTATATGTGTTATAGATTCCACAGCAGCGT TTGAAACTATTCTTTCAAAGGCCAGTTGTCTTACGAAGAAACTTAAAAACTAAGAATAACATTCCTTTA TATTTACCTTCATATTTACCATTTTTATTTATTTTCTTTGTGGAGATTCCTTTTTGTAGATCCAAGTTTG TTGCTGGTGTTATTTTCCTTTACTTGAAAAAATTTTCTTA AACATTCTAAAGTATAGGTCTACTGGCTA CAAAATCTTTCAGCTTTTGTTTGTATGGAAATGTCTTTATTTCACTCTTCATTTTATCGTACAATTTTTCA AACCACACAGACTTTAAAATAATTGTAGAATATAATTTCACACATTTTGTTCTATTTGTTATTGTCTTCT ATCTTGTCCATTCTATCCATCCTGTCTTCTTCTAGTGTCTTTTTTTA TGCTTTTCAAAGTAAGTTGCAGTT GTTAGTATACCACACCCCTTAACTTGAGCATGTATGTTAACTAAAAACTTAGTAGTTTAGTATTTTTAACTA GAATTTACTATGCTGTTCCAGTTATTTATTGCTGTGTAATACATTGCCCCAAACTTAGTGCCTTAAATAT CAGCAACTATTTATTTTGCTCATGAATCTTCCATTTGGTCAGGGATTGG CAAGGAGAGCTTGTCTTTG ACAATACATTGTAACAACTGTTTACATAGCATTACATTGTATTTGGTATTATAAGTAATCTAGAGATGGT TTAACATATTTGAAGATGCATGTAGGTTATATGCAAATACCATGCCATTTTATATAAGGGATTCGAAGC ATCCTTGGATTTTGGGATCCATGGGAGTCCTGGAACCAGTCCTCTGTAG ATAGTTGAGGTATGACTGT AGTCTTTGGATTGAAAGACTCACTAATTTCACTCAGATTCAAGGAGAAGGGCCATAGACTCCACCACC TGATGAAAAAATGACAGTGTTACATTGTTAAGAGCATGTGGAATGGCTTCTATTGTGACCATCTTTGG AAAATACAGTTGACCACATATACCATTTCATGAGCTGTGACAAATGTATACACCTTT GCCAGAAAGTTC TATCAGGGTATAGAACCTACACCTCTTCCTAGTTATTCCTTCCCCCACACCACCCTAGAACCTAAC ATTGTTCAGATTGTTTTCATCTTAGTTTAGCTTGCGCAGAACTTTATGTAAGTAGAGTCATACAATACTT ATATGTTGTAAAAAGTTTCTTTTTTGCTCAACATAATGTTTTGAGATTCATCCCATATTGTTGAATGTTTC GG TGGTTTGTGACTTCATCTGTTAAGGGACACCTGGGCTGTTTTCAGTTCCAGGCTGTTTTCAGTTCC encenn / Lznz / B / YiAi CAGCTATTATAAAAAGGTACAATGAACATTTGTGTAAAAAAAGAAGTCTCTGTGTGGACATATATGTTT CTTTTTTCTTGGTTAGTTGATGTGTTTTTCTTTCAGCATTTGTTTTGATGAGAAGTCTGGTTATACAGT CATGTGCCGCATGCTGACATTTCAGTCAACGAGATCATAGTTGACAATAGTCATTTAAGATTATAC CA CCATATTTTCACTGTACCTTTTCTAGGTTTAGATGTATAAATACTTACACTTTGTTACAGTTGCTTACAG TATTCATTCAGTATAGTAACATGCTGTACAGCTTTATAACCTAGGAGCACCCGGGCTATACCATGTAT CCTAGTTCTGTAGTAAGCTATACCATCTAATCTAGATTTGTGTAAGTACGTTCTATGATATTTGCACAA TGATTACCATG CTGAGAGTTGTTGGGGTTTTGTTTTTTTTTTCTTTTTGAATCTGTACATTTATGGTTTT CCTTAAATTTGGAAGATTGTTGCCATTGTTTCTTCTATATATATATATTTTTTTACCACCTTTACTCCTCTTTC ATCATTTCCTCTTTTTCTGGGACTCCAGTTACACATATGTTAGACTGTTTGGTATTATCCACAGGTCAT TAACATCATATTCATTATTTT TCAGTCAGTCTTTTTATTTCCCTGTGCTTCAGTTTGCTTTGTCTTCTATTTTAC TGTTTTTTCTCCTCCCTTGTTAAATAATTTCAGATATTTCGCTTTATATTTCAAGAAATTCCATTTGATTC ATTTTATTCATGTATTTTTTGAATTCTTGAGCATATTTGTAATAGCTGTTTGAAAATCAGGTTACTTATT GATTTCTTGAATTTTTCACTCTGAATTTGTT GGTTGGTTTTTTCTCTTGGTCATGGGTTGTATTTTCCT AGTATTTATTTTATTTTATTTTTTGTTTTTTACATATTTAATGATTTTTTAAGATTGGATGCTGGACATTGT AATATTTTGTTGTTGGGTGTCTAGATTTTGTTTTCTTTTAGAGTGTTTTGTTTTGTAGCCACCTAAATAA CTTGCTGGTCAGTTTTATCCCTTCAGG GCTACATTGGAGTTTGTCTAGAGAAGGCTTTGCTTTAATGG TAGTAGCTCCTACCTAAGGCATGATCCTTCTGAGTCTTTACTAAATGCTCCCAGTGTCACCGTGTTCT CTTCACTCAGGTTAGAGAGAATTTTAGGAGTCTCCCAGTCCTTTATAAGTACTGGGAATATTTCAGCTT ACTGCCCCTCTTTCACTAGCTTCATGGAGTCACTTA CCTTAATCGTGTACAGTTAGTACTCAGCAGTG GACTCTCAAATGGCAGATTTCTGAAGCCATTTCTCTGCCTTCTCAGACAAGCACTTGTCTGGCACTTG TCATCAATTTTACCCACTTCAGCTTTCTCAGCTCTGATCTCTTGATTCTGAACTCAGTAAAACTGCTGT CTTCTCACTGGATTTCCCCTCCATTGACTGCAGGTTGGAAATTACCT CCAGGCAGACATCCAAGCAGT GGATGGCTCACCTCCTTTGTTTTTGTCCTTTCATGCATTATAGTCCTCTGCTGCCTGTTATCCAAGGTC TGAAAATTTCCGTTTGAGAAGGAGCAACTGTCAGATACTTTCGGATCTTTCTCTGAAATTAGCTTTCTG TTGTGCTTGTTGTGCTTACCTCTTTGTCTAATGCTAATACCATATGAGG TTTTTTTTTTTTTTTTTAGAAT GTTTTAAGCTATACACTTCTAAGTGTATAGCTTGTTGCACTTTCACACACTGAGCACCCGTTTAGCTAG C ATTC AG ATC AAAAAAC AG C AG C AG CTCCTGCGTAG CCCCTTGTGCTCTGTGTCACTACCCCTTTTTCT TCCATGTGTAACCACTGTCCTGACTTCTCATAGCATAGATTAGATTTGC CTGTTTTCATCCTTTAACTA GAATCAAGCACATTTAGTTGTGTCTGACTTCTTTTAATGTATTTGTGAGATTTATTCACATTGTTGGTTG TAGTAATTGTTTATGATAGTCGCTGTATATTCCATTTTAAGAATGGAAGTGATATTCCATTTTAAGAATA TGCCATAGTTTAATCTGCTGTTACGGACATTTAATCATTTTTGGTTTG GAACTGTTAAGAATATTGCTG CTGCTCTAAACATTTCAGTGATTGTCTTCTTGTGAATATGTTTACTTCTGTTTGGTATACTTAAGAGTGA AATTTTTAAGTCATAAGGTATGCATATATTTAGTGTATACTCAGTTTTTTAAAGGCATGCCGATTTTAAT TATTCCATTTAAGTTAATATGTTTTAATATCTGGTAGAGAAAGGAACAT TATTAGAAACAATTGTTTTGG TTATTCTTACATATTTAGTCTTTGAAAAAACGTTTCTTAAATTGGCATTTACTTATATTTGTGTTAATTTGGGAAGAAATGGTATCTTTGTTCATCTATGAGTCACATTTGGAACTAGCTCAAAGGCCATGGGTCCTGA TTCCTTTTTTTTTTTTTTTTTTTTCTTGTAGAGGGGAGGTATGGTG TCAAGAAAACATAGTCACCATTAT TACGAAAAGTAAAATATGGAAGAGATGATCCCTACCATCAATCAGCTTACAACTAGAGGCACTGACAA pncrnn / Lznz / B / YiAi ATGTATACAGATAGCTGTAATGTAAGGTATAACATAATAAATATAAGGAGAAATTAATAAATTATTTTAT GGTATTAAGAATGTATAATAAGACATGAAGGAGATGGTGATTATGTATAAGAGTTTAGATAACCCTGT GAGATACAGTGTTTAGAATGAGGCCAGTTTTTAACATGGCATGATAGGTGGGTGGGGGATAGAGGTT A GTAATGGATAGAGGACCATTTCCGAGTGAAGTCTCCTCAGAAGCAAAAGCATTGAAGTCAGAAACA CAAATATCCAGTACATTATAGCCAATAGTCAAATGATGGGACTAGATCTGGTAACTGGTGATGATGTC ATATAGTGGGCAGTAGTGCTGGGATGGCTGGGGTCAGGGCCACATGGCAGGGGCCTCAAATAAAAT GT GAAGGAGTTAGAAATTTATTCTGTTGGCATGAGAAAGTGTTAAAGCTTTTGAATATAGAATGATATG TGTAACTTTGAGTTTTTAGGAAGATAATTCTAGTGGCAAAGTTGAGGATAAAGGCAAAAGGGAAACCA GATGAAATAATGGGGCACTGTAGTAGGACAGTGTTGGTAAGTTTGAGGAAAAAAGGAGTAAGAGATA TTTT TAAGGAAATTCATAGGGTTTGAGTATAAATTAGAAGGCAAGTACAAGGGAATAAGCGTGGTCTT TAGAATCAGACAAATTAGGGTTTGAATCTTAACCTTGCATTTACTAAAGGACTGAAAGCTAGTTCCCTA AGAGAAAAATTTTCTCTTTTGTAAGATGCTTATTCTATAAACATTTGCAAGCACTGGAAGTATAAAAGC AAATGATACACATG TTCTCTTGAAGTCTGGTCTAGTCTGTAAGAAGAGGCTGCACTGGCAGGTTTTGA CCAAATTGTGTAGAATCTCATCTGACGTGATTGGGAGCTTTGGCTTTATTCTGGAAGCAACTAAAAGC AATCAAAAAAGACTGGGGAATAATGTGAGAATGTAGAAATGTAGGGGAATTTCTAAGGATGAATTGGT AGCAATTG GTAACAATTTGATATACTGGGAAAGAGAGAGACTCTTTAGAATATGACTGAGAATCTTC CAATTTGAGCAGCTGGACTGATAGTGCTACCATCATTACTCTCACAGGGTTTTTCTTAGTGTGTCTTGT AAATCTTGCTTGTCCCTCATAAAGAATGGTTTTCCTTTTCTTCAGACTAAGGACTTTTTATTACAGTACA CAACTTAACACCCCCCTGTATCTC TCCATCACAACACTTAACTGTGCATTGTTATTGCATAATTAATTGT GGTTTTTATTGTGCCCATTTCCTTCACCACATGAGGGCAAGAAATTATGTCTAGTTTTTCTACCTCTG CATCTTCATCCACCTAGTAGGCACTCAAAATCTAGTAGACAGTTTTGAATTAATGATTATGAAGAATT TGAAGGCTGAACAAGTATCAACCTACACAG TGGTTAGGGCAAATAAAAATGAGGGGGAGAAAGTAAT GAATGGCACCAATtTTTTTAGTCCTTAACCAGGACAGTGAGATTAGGCAGAGTGAGTTCTTTGGGAAA ATAATTGAGTTTGATATTAGATACGTTGAATGTAGATGTTAATGAGACATCCAAATGGATGTGTACCGT TGGTAATATGTAGTTGCAGGC ATACCATGCCAGACATAAGGACTTAAAGATACAGAGTTAGGGGTTTG TAAGCATAGAGGTGCTATGGGAATGGATGACATTGCGCAGAAAATTGGTTTAGGTTAAGAAAAGTGG CTATTGACAGAAACTTGGAGAGAGGCCATGTATGAGGTAGGAAGATGAACTAGCAGAAGACCTTATT GCCTTTAGAGAGATGGAAGAAAATGAG TGGATACAACATTAGGGAAGCCAGAGGAGGTGAGGAGTC ATTAGCAGTCTTAAAAGCTACAAAAATTAAGTAGGATTAAGGGGCCAAAGCACTGGGAATATACAGAA ATGATGGAAACTTTACAAGAAAAATTTCAGTAGATAGAAAAATAGCAGCTGAGCTAGTGGTTTTCACGTCTTTTTGGCAGTAAAAGGAAAGAAGATAAAGAAATG GTACTCTGAGGAGCTAATGGAGTTGAGGGA ATTATGTTGCAAGTATTATTTGAAAGCAGTATTTAAAACTTTTTAAGTCTTAACTGCAGAATGGACTGG AATAAGGAGAAACTAAAGCAGGAGGACTTAGGAAAATTGTTGTAGTAGTCCTTTAATTGTGAAATGTG TAAACGGACAAAACTTAGACAGTTTTAATAAGTAGCATTATCCATA AATATAAGACACCATAAACATGA TGCAAAGGAGAACAGAAGTGTTGGGTGTTATAATAAAAAGTGATAGAAAAAAAACAGTTTGTGAAATTA AGTTTTGAAACAGCTTTAGAAGGAGGTGAAGGAAAAATAGAAATGAATAAAATGAAAATTTTAGGGAG GTAGATATAGATCAACATAGGCATTTATTATTAGACTATACTTATTTATAAGATTATTAG ACTGAGCCCT CTGTTGAAGAGATAAAGTAAGAGAACTATGTCTGGTATTAGGATTCTTATGGTTAAATTGGCAAGTGA rncrnn / Lznz / B / YiAi GTGTGCCTAATATTTGTAGTGCTTACAGTTTTTGTTATTCTGTATTTTTATAGATTTGGTATATTTCCTC CATGATTATGTGTTCCTAACTCATAATTTGGAAGGCAGGGCTTCTAAAATGAGATCTGTGTGTCATGT GAAGTATATGTTAAAATGCAAATTCATTTCTGCGTTCTTGGGTTGGTCTGAAAAAAA TTAAAAAAAAAA TTCATTTACCCCTACTTCATGCACTGAATGAAAATCTTTGCGAGTAGAGCCCAAGTAGTTGCATTTTTA GATTCCCCAGGTAATTCTATTATAGACTGAAGTTTGAAAGTCAGTCTCTAAAACCTTAAAAGTTGGTT AATTTTATTTCAAAATGTTTTATATGCAGTGTATTCACTTTCTACCATCAACCTCTAGGACACTGGATAG GTTTCT TAACCTTTGAGATTTGCTTTCTTTATATGTAATGCAGTACATGAAAGGACTTTATTTTGTTCC ATTGAGGAATGTTCTGATTGTATACAAACAAGTTAAGAATTTACAGTGATAATTTAGGGGCTTGCTTTA AGCTTCAGGATTTTTTTTTAAGAGTTAAGTTTTGATATATATTAAGTGGTTGATTTAATAAATTATAATTA TCGTCGTATATTGAAG TCCTGTTTTGTGCCAGGTAGGCATTATACTATAACTTTTTAACGCATTTTCTC TGCTACAATAACCTGACATTGGAGACTCAAGGGTCAGAGGGTCGGCCCAAGGCTGCTACTCTAGAAA GTGGTAGATGCCCAGATTTGTACCTAACATAGCCGATGCTTAGCATATAGAATTTAATTAAAAACAAAA TTGCTATAGGTATTTGAAAGGATTAG AGGGATATAGTCAAATAGTTTTCATATGTGTTTAGCCCTTTTG GAGGGAGGATAGAGTAAATAAATAGAAGGCACTAAGCTTTATGGATGAATATGGGAAATATGGCTTTG CCTGCTGAAAGCACTCAGGCCACAGGGCCTGCCTACCTATGCTTTCCTCATCCCGGCAACAGCAGTA ATTTGTTTCTTGATACGTTTTTTGGAT GTTCATAATTATAGAAAATAAATTTGCCTTTATGATGAAATTTAG TACCTTTTTTTTTGAAAGTTCATCCAGTTGTTTATGTAAAAAGAATTGAGTGAGGTGTTTTATATTTTAG GTTAAAAATCTGTAAGAGCCTGATTTTAGAATTCACCAGCTCCTCAGAAGTTTGGCGAAATATGGTAT GTTTTTGTTTTATTTTTTGGAATTCGTATTG CATGTGTATCTTAATGTCATAATAATGACAGATGTGTTC AGCAAATTTGGGCCCCTGCCATTTTAAAGCATTGTGTCAGGTGCTCACTAACTACACTTCCAAGACT GTATGAGGGACCCAGGTAGGGTGCTGAAAAAATTTACAAGAGATTAGTGTGCTATGAGAGGTAAAAT AATATGCATAAAAAGATTGAGAGGGCAGG TTTGGATTTTGGGCTATGAGTATTAATAATAGCTTTCATT TGTTGTTGTTGTTGCTGCTGCTGCTGCTGCTGTTGTTTTTGAGACAGAGTCTTGCTCTGTTGCCCAGG CTGGAGTGCAGTGGCACCTTCTTGACTCACTGCAACGTCCATCTCCCAGGTTCAAGTGATTTCCATG CCTTGGCCTCCCAGGTAGCTGG GATTACAGGCGTGTGCCACCACACCTGGCTAAGTTTTGTATTTTT AGTAGAGACGGGGTTTCACCGTGTTGGCCAGGCTAGTCTCGAACTCCTGGCCTCAAGTGATCCACC CGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTTAGCCACCACGCCCAGCCATTTGTGAGCAC ATTATGTCAGGCACTGTTCTGAGAT ACTTAGATGTTAGCTTGTTTATCCATGACAGCTCTATGGAATAG GTACTATTATCCTAGTTCTACCTATAAGGAAACTGAGACTCGGAGAGGTTAAGTAACTTGCCCAAGAT TTCTCAGCTAGTGAATGACCAAACAGAGACATAAGTCCAGCCTGGCCTTGGAGCCTTTTGAGCACCG GATCTCATAAAAGAGGGGACTGGAAGAGAGGACTTGACTCTAGTT TTCAAATACATATAGCTCTTTA ATTACATTGAGGTCAATTAGTCAATTAAAGATATTTTAACTTTATTATTTTTGTGTTTACAAGATGGAA AGTTAGACTTGTTTGAATCTTCTAATTCCACATACCATTAGTCTCTTGAGAACCCAAGGGGAAGCTGTA TCATGACCACATTGTTTATTTTAGGGAAGGTGGTGTTTCCCATATGACCTCAG CAATGTCTAAGTTCTT ATTAGGCAATGTATAGTTAGGATAGGAGTATCTGGGAGATTGCGTTATTCTTACAGATACTATAAATC CCATTTATTGGAATCCCCTGCAATTATTTTTATATATTCAGGCCAATCCTCACCTAATCTGGATTTTGAA GCCCTGCGTTCATAGCTGCATAGGTATGGGCTCAAACATTCATGTTTTAACCGTTGG TATTCGCAGAT ACCTTGCTGTTTTATATTGGGTTCTGAATCCACACTGGTAACCACCTTTTACGCTTGACTATTGTTGCT rncrnn / Lznz / B / YiAi TTGAGGATGTTAATTATGAAAGGTTTCTTCCTCCTAATTTCCTCATCTTTTCCGTAGTTGATGCCTCAGA TTTGGCCTGGATAGGGGAATCGTGAGGGGAAAGAACTAGTTGCACAAAATGATCTTTTGATACTGGG ATATTTCAGATGTATGGTATCTTTGCCAGAACTACAGTGTCAGTAAAGAGGCCTGCTAAATTTGAACT GT GACAATCAGAAAAGTTCAGCTAAGGCCATGTAAGGGGTTAAAAAGATATTTGGTTGAGGGAGGAG GATATGCTTTCATCTTTTGCCATACTTTTTTCATGAAATTAATCTTAGTAGATTTATGGCCAAGAAAGAG TAGAATATATTTTTATGCAGTACTTAAGGGGTTTTGACTGATGTTTTTTATTATTATTATACTTTAAGTTT TAGGG TACATGTGCACAATGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGTGCTGCAC CCATTAACTCGTCATTTAGCATTAGGTATATTTCCTAATGCTATCCCTCCCCTTCCCCCCACCCCACAA CAGTCCCCAGAGTGTGATGTTCCCCCTTCCTGTGTCCATGTGTTCTCATTGTTCAGTTCCCCACCTGTGA GTGAGAACATGCGGTGACTGATGTTAAATGACTTTACGTACATACAGAATTAGTGGGACTAGACTTTG TGTTTATGTGTGTGTGTTTATGTGTATGTATATAACTATTCCATTAAGCAGTTGCCCTCCTTGGTGACTGATTGCTCTATCAGCTTAGGAATCTTTTGACTGAATTTGTCCGTATTTGAAAGATCTCAATCTGT GTTC TGAATCTTTACTCATTTACATATACTTAAATCTTGAAACCCAGTATAGCAAAACTAAGCCAAAACAAACA AAAAAATCCATCCCTTGATAGGAAGTCAGTATATCTGGGTTTTAGTCAGTCCTTCAACACTAGTTCCAA AATCTTGGGCAAGTCAGTTAATCACTCGGAGGCTGCTTAATTTTTTTTTTTTTAATTCTTAGTATATTA TCTGTCTTGATT AGGTAAAGCCAAAGTTGTTATAAGACTCAAGGTACTATTGACCAAAATGCTTCAGAA ACTATAACATTACATAAAAGTACAAGGAATTATTACATTTTCTCAAATGAAGAGATCATTTAAGAAAAAC AAAATGCTGGAAAATAGTCCTTAAAAACTTTTCTATAATAATTACTCTTCTGATGAATTTTACATTGACA CCTAATTTGAAGCTTTGAATATTATTTTTTGAACAATGA ATTGGGTTTATATATTAAAGTGTTCTAACCA AAGGTTTGTTTAATTTATTAGAGGTTATTAAGCCTACGCTCAGATCAAGGTAGCAGCTAGACTGGTGTG ACAACCTGTTTTTAATCAGTGACTCAAAGCTGTGATCACCCTGATGTCACCGAATGGCCACAGCTTGT AAAAGGTAATTTTGAATTATTTTACAGCCTTTAAAAGG CTGTCATTGTAAAGTGAAATACATACTGTAAA AATGAAGACAATGTATAGTTGGCAGGAATACTGCTAAGAATAGTGGGCCTGAGAGTTGACCTACTTCA TTTAATCTCCTTAAAATATTTTAGTGTCTTTTTTTCTCATTAAAAATATCAGTAGCCACTATCAAAAGACCT ATCTGTATGTATAAACAGGAAAGTATTTCTCAAAAAAACTTCAAG GTTTTAAACATTTTACTATAAACAT TATAGAAAACATTAAAAATTCTTAATATGCATTTTAAAGTATGCCTTTTATGTGGTGAACGTTTTAACT AAACATTTCTCTAGAAGTTTTTATAACATTAATAAAACTAGTATACTTTTCTCTCCTAGAGAGTTACAGT GGAGGTAAAAGGAGTGGCTTGCAGGATGGAGAAGCTGCACCAGTGTTATTGGA AGTGAGCCACCAT TTGAATTTGCTAGCTCATGCTGCAGTATTCAGATTAGTGGGTGTTTTGTGATCATATTTTCTGCGATTC AAATCAAGACCTAAAATTGATTCTCATTCTGAGATTTACATTTTATTATCCAATGTTATTTGGTTATTGTT TCAGTTTTAAAATTTCTGACTTGTTATTCTGACACACTTTAGGATAACCTAAGTCAATAG TTTAATACAA AAATTTCCCCTTTGGTTATATGTTTTGAATTAGGTTATATGTTCTGCATTTACAAGCACATACAGGATTCT TACTTCCAGCAACTTGGCAGTAAAAGAATAAGTAGACTCTTTAGGAGCCAAAGTCAAGCTTGGGAACT GTTGCTAGGTGGTATATATTTCATAGTTTATGTTTGTTTCCAAGACAAGGTCTCACTCCATCGCCCAG GCTGGAGTGCAGTGGCACGATCACAGTTCACTGCAACTTTGACCTTCTGGGCTCAAGTGACCCTCCC ACCTCAGCCTCCCAAGTTGCTGGGACTAAAGGCACCCACCACCACACCCGGCTAAGAGACGAGGTT TCATCATGTTGCCCAGGTTGACCTTGAACTCCTGAGCTCAAGTGGTCCTTATGTCTTGACTCTCCAAA GTGCTGAGA TTACAGACATGAACTACCACACCTGGCATATGTCATAGTTTTGAGAGTTTGAATTCTAA pncrnn / Lznz / B / YiAi CCTCGGGACTTTGGTAACTTATTTATAATATTCTAGAAATATACTGTTATTAGGATGAGTAGAAATTCAT TCAGACAGAAACTATTATAAATTACTGCAAGAAAAATGTCTGCTAGTTCTGCATATATTCATTTTTCTCT TGATTAAAAACAATTTCCAATTTGAGTAGAACAACTTTGCTATGTTTAATAGACCCAGGACAGATTTA TTTTAAGGTAATAATCT TTCAATCCTTCTTCTTCTATACTGGATTGGTTTAAATTACTTAGCTTGTCTTAT CAATGGTTTTTAATAGCCTACTTTAATATATGTAAAAAGTAGTAATTAATATGTTACAGTTTGGTGGCAA ACATTTTGATGCCAAAGTTCACATATTCTCTTGCTTAGGGAACAGAAATTGGGAAGATAGATGTAGTTA TCATTTGATAATGTATTTA AACTCTATCCCATTTCAGGATCTCAAAACTTTGTAACAGTTACATATTGTA CTTCTAAGACTTAGATTTGTTTTTCTTCTTGTGTCTTACCTTTTTGCAGTAATATTTTTATTTTCCTATCA TCATGTCCTCATTTTTCCCTCTCTTCTCTTTCCCTGTTAATTTTGAAAGTTTTGCTGCCTACGTGTTTG AAAACTTCTAATCTGCCTCTCTTCCCTCAG TGCCAGCAGGTTTATTTTTTGTTTTGCAAGCCAGCTCTG CCTCCTTACAGTATGACATCTGATGCTGGAGGGTCGCACTTTCAAAAATGAGTCAGCTGGTACATGG GGTTATCATCAATTTTAGCTCTTCTGTCTGGGAGATACAAGTTTGGAAGCAATCTTGGGGTACTTAC CCACAAGGCTGGTGGAGACCAGGT GTGTCACATAGGTGATTTGCTTGCTCCCTGGGGGAGAGGGTG GAGTGAAATTTTTGCATTTGTGTCACAGCCAAGTCACTGCCACCTCCAGCATGCCCCAGTTTTTAGTT GTTATGTAATTTTGTGCAAAATTGAAAATTTAAATACATTGCAAAGAAGATCTAAAATAAATATTTGAGC TGCTGGAGTCTTTTTTTTTTTT TTTTTTCCTTTTCCATTCTTGTCCTTGGAATCTGAATGAATTGCAGTG AGGGTAATTTTGAGAGTCTGATAAAGAAGTGAGGGGTTGTTTTTTGTTTTTGTTTTGTTTTTAGCTAA GAAATTTAGAAAACAGGTTTGTGTGTGTGCGTGTGTGTGTGTGTGTGTGTGTGTGTGACTGATT TTAA GATTCTTGTTAGAGTTGCTTAAAGTTGGAAGCCTAAAGTCAGTGAGAAGTTCACAAATCAGGACTTTG TAATGCCAATTTGAAAATTTAGCTTTTGACCTCAAAAACATTTTTTATCTAGTTTGGGAATTTCTAAGT GTTAGAAATCAATATTATATTGACTCATTCATTGTTGCTGATGCTGTTTATAAAAGTGAATAGATAGGG AAATACTG ATTCATATCTCGTGAAATGAAAATGAAAGGCTTTTTAGTGACTTAGAATTTTAAATATTTCT ACATGAGAGAGCAGTAGTATATTTAGAAATAACAAAGTAACTGGCAACTGTTTAAAACTGAAGTTAATT CACAGCTATCCAGTGCAAAACTTCACCTCAGGTGATACACTTTTGACAGGTAATACATACAGTAAGTG TATTTTAGGGAAACAGTTTCATT GTTGAACCAAGATAATCATCATTAGAATGTTGTATCTGATTTAAGT GTCTTTAAACTTACCAAGGTATTAGATTTAGTTTGAATTGTCTGGAGTAGCGGTAGCGGTTGGCACA TTTGTTCTTAAAGGGCCAGAAAATAAATATTTTAGGCTTTATGGGCCATGTGGTTTCTGCCACAAGTCC TCAGCTCTGTTCTTTTAGTGT GAAAGCAGCCATAGATGATACCTAAATGAATGAGTATGGCTGCATCC CAATAAAACTTCATTTACAAAACTACATGGCTGGCCTAAGCTTTAGTCTGTCTGCCTAGGGAGTAGTTT ACTGAGCCACTAATCTAAAGTTTAATACTGTGAGTGAATACCAGTGAGTACCTTTGTTAATGTGGATAA CCAATACTTGGCTATAGGAAGTTTT TTAGTTGTGTGTTTTATTACACGTATTTGACTTTGTGAATAATTA TGGCTTATAATGGCTTGTCTGTTGGTATCTATGTATAGCGTTTACAGTTTCCTTTTAAAAAACATGCATT GAGTTTTTAATAGTCCAACCCTTAAAATAAATGTGTTGTATGGCCACCTGATCTGACCACTTTCTTTC ATGTTGACATCTTTAATTTTAAAACT GTTTTATTTAGTGCTTAAATCTTGTTTACAAAATTGTCTTCCTAA GTAATATGTCTACCTTTTTTTTTGGAATATGGAATATTTTGCTAACTGTTTCTCAATTGCATTTTACAGA TCAGGAGAACCTCAGTCTGACGACATTGAAGCTAGCCGAATGTAAGTGTAACTTGGTTGAGACTGTG GTTCTTATTTTGAGTTGCCCTAGACTGCTTTAA ATTACGTCACATTATTTGGAAATAATTTCTGGTTAAA AGAAAGGAATCATTTAGCAGTAAATGGGAGATAGGAACATACCTACTTTTTTTCCTATCAGATAACTCT encenn / Lznz / B / YiAi AAACCTCGGTAACAGTTTACTAGGTTTCTACTAGATAGATAAATGCACACGCCTAAATTCTTAGTC TTTTTGCTTCCCTGGTAGCAGTTGTAGGGAAATAGGGAGGTTGAGGAAAGAGTTGAGTTTAACAGTCT CAACGCCTACCATATTTAAGGCATCAAGTACTATGTTATAGATACAGAGATGCGTAATAATTAGTTTTC ACCCTACAGA AATTTATATTATACTCAAGAGTGAAAGATGCAGAAGCAAATAATTTCAGTCACTGAGGT AGAATGGTATCCAAAATACAATAGTAACATGAAGGAGTACTGGAGTACCCAGGTATGCAATAGGAATC TAGTGTAGATGGCAGGGAAGTAAGAGTGGCCAGGAAATGCTAAGTTCAGTCTTGAAATGTGACTGGG AATCAGGCAGC TAGAAGCATGAGCGGCTTATTCCAGGCAGAAGTATGAGCCAAAGTTAGAAGCAGCA TAGGGAGTAGGGGACAATAGGCAGTTGAGGACTTTTAGATCATAAACTAGCTGAGAGGTAGGAAAAT GAAGAAGATAAGATGTGATAGAAGGTATTAGGGAGTCAGCAAAGAATTTGCTCAGTAGGTAGATAGTA AGTTTGTCAAACGTGTATT TTTAATAACCTTGCAAGAGAGAAAGGATTGAAGAGAAACGTGTGGTGGT AAGGTAGTTCAGTCAGTGAGAGCCTTGACAATGACAGTGGTATAATAGGAATTCAAAATAAATTTTCT GGATTTAAGACAAATATTTAGGACATGAAGTAAGTAAGACTTTAGTGATTTATTGTGAAGACTAAAGATTGTTTCAGATAATAGAGGTAGTAATTATCAAAG CAAAGTTTTTCGAGGTATTAAGGGTTGGAATGAAAAA TACAGGTGTATCTCTCATACAGGTAATATAAAAAAAGAAAAATGCAGATATAGTGATTGACCTTGAATA AGAGGAAAGATGCCCATCTAATGAAATTAGAACAAGGAAGTAAAGATGGATGTGTGATATTAATTGTA ATTGTGGGTGAGGGTGGAAAAATCAAGATTTTT TTACTGAAAATATTGGAACCTTATTTAAATGCCGGT ATATATTGTGAATCTGCAAGAAACGACTATAAAATGTATTTCTCAAATTTATGTGACCCAACCATGTGA CTTGTCTTTTAAGCTTTAAAAAATTGTAGTAAAATACACATAATGTAAAATTTTCCATTTCACCATTTTTA AGTATTTGGCTCAATGGTATTAAGTATATTAATATTGTTGCA CAGTCACGATCAGAACTCTCTGTTTTG CAGAACTGAAACTCTGTACCCATTAAACAATAATTCCCTCATTTCCTTATCTTCACAGCCTCTGACAACC ATTATTCTACTTTGTGTCTAATTTTGACTGCTCTAAGTACCCCCTATAAGTGCAATCATACAGTTTTGC CCTTTTATGATTGGCTTATTTTACTTCGCAGTGTCATCAAGTTTCATCCATCTTTAG CATGTTTCAAAAT TTGCATCCTTTTTCAGGCTGAATAATGTTTTATTGTATGTATATACCACATTTTGCTTATTCCATTTACCT GTTGATGAGCGCTCAGGTTGCTTCCATGTTGTAGCTATTACAGATAATGTTGCTATGAACAGGAGTGT ACAAATATCTTTTTGAGACCCTGCTTTGAATTGTTTTCCCAGAAGTGGAATTGTTG GATCATATGGTAA TTTTATTTTTAAAATTTTGAGAAACTGCCATACTCTTCCAGAGCAACTGTACCTATTTGCGTTTCTACCA CTAGTGCACAAGGGGTCCAGTTTCTCTACATCCTTGCCATCACATATTGTGTGAGAGTGTGTGTGTGT GTGTACTTCAATAGTAGTCATTGTAGTGGATATAAGGTAGTATGTTACT GTAGGTTAGTGACCACGAA ACTTTTTATGAAACATTTTTAATAATATTTTGTGGAATACAAGGTTTGTTTAGAGGTTTTGAGAAGACT GAAAACTTAGGAAGCTACTGAGGGGAATGGGTGAAGAAGTGGATCAGAAGTTGAGAGTCTTGACTGG CTGGCTACCTGAAATCAGAAACCGTATCAGAGTAGGAGAATCTCATTCCACTGAGTG ACTAGTTAAGA TTAAAGACTTTATCACATTTGAAATTTAAAGACTTTTCTCCAATAGCCAGAAGATTATGCATGGTATTTT AGGGTTGGATATTAGCAGAGCTGATGGAACAGAATCATTAGTGGCATGTGCATAAGATGTTAACATTG GAGTATTTGAATTTATATGCTGTGGATGATGGCCATGATTGGAAAGGTTGGGATGCC AGACCAAAGT GTTGAGTTGTTTTAAGAAAAGCCTGAGGTCTAGATAACAGCAAGATGGCAGACTAGCACTTTGCAGCA CTCATCTCATTGTAGAACCATCAATTTGAACAACTGTCTACACACAAAAATATAAGAGCTAAGAAACCA GACGAGAGATTACCTGAATGTGGCACACAGATAAGAAAAGACACATTGAAAAGGGTAAGAAGGACAG TTTTA CATTACTTGTGTCACACCTCCCTCAGTCCCTGAGATCCCAGCATGGAGAGAGAGACTGTTCAC encenn / Lznz / B / YiAi CTGGGGGAAGGAGGGGAAGTGTACACCAGACTTAGACCCTAACATTGAGCTCGCCCCAGTAAAACT CAATGCTAGGCAGGCCCCCATGGCCCCAAACTTCAGGCCAATACCCACAAACCAAGCTTGGAGGCC CACCCCAGCACCAAGCTGGATCCCACAGCCCTAGGCTCTAAGCCTGTCTAGTGCTAGGGTGGTCCC TGCAGCC CTGCCCTCTAGATCGGCCCCTGTGGCCTCACATCACTGCAGAACAAGGGTCCAAACCCA GTACTTGGCCAGCCCCTTGTGATCCAAATTCTAGGCCAATCCACCTACCCAGCCTTCACACTGGT CCTTGCAGATCCAAGGTTCAGGCTCACTCTAGTAGACCAGGATGCCAGGCCAGCAGCACCTGTGTAC CAAGGCTCCAGGACCTACC CTGCTGACCCAGACTCCAGGCCAGCCCCGGTAGACTCAGGCTGCATA ATCTCTGGACAGGCTGACTGGTGAAGGGCTTTACCCAATAAAGTCACTCTGCAAAGACTGGAACAAG TCTCAGCTTCTTCAAATGTGCAGGTGCCAACACATGACTACAGGGATCAAGAACAGTCAGGGAAACG TGACACCAGTCAAAGGAACACAATAAGGCA CCTGAACCAACCATAAAGAAATGGAGATATATGAACTG CCTGACAAAGAATTCAAAGTAATTGTTTAAGGAAGCTCAATGAATTTCAAGAAAATGCAGATAAACAAT TCAACAAAATCAGGAAAACAGCAATCAAAATGAGAAATTTTGAGATTGAAATTATTTTTAACAAATTCT GAAGCTGAAAATGCAATAAATGGAATGAAAAATGCAAAAGAGCATTAAAAG CAGAATTGAGCAAGCAG ACAAAAGAATCTGAACTCAAAAGACAGGTTATTTGGCTAGACTAAGGAAAAAAGAGATGACTCAAGAT AAAAAAAATAAAGAGTTGTGTTTTTTGATGATAAAAGCAACAAGTCTTTAGCTAGACTAAGAAAAAAAAG AGATGACTCAAGTTAAATCAGAAATGAAAGAGGAACCATTGCAGCTGATACCAGAGAAGTACAAGAAA TA AGAGGATCATAAGAGACTGAACAATTATATGCCAACAAATTGATTACCATAGAAGAAATGGATAAAT TCCTAGACACATGCAACTTGTCCAAGCTTAATCATGAAATGAAAAATGTGAACAGTCCAGTGACAAGG ATTGTATCAGTCATAAAAATATCTCCCACCAAAGGAAGCCCAAGACTTGGTGACTTTACTGCTGAATT CTAGCAGACATTTAAAGAAGA ACTAGTACAGATTGTTCTCATAATTTTATGAGAAATTTAAGAAGAGGG AGTAATTTCAACTCATTTTGGGAGATGAGCATTACCTAGATACCAAAGCCAGACAAGAACTCTCCAG GAAAAGAAAATTACAGACCCGTATTCTTAATTTAGATGCAGAAATTCTGAAGAAAATAATAACTAAATT CAACAGTGTATTAGAAGGATCATTTACTGTGATCATATGGGATTTA CCTCAAGGGTACAAGGATTATC CAACAGACCTGAATCCATAAAATGTGATATACAACATTAGGAGAACAAAGGCCAAAACCATGTTATCA TTTCAATAGATAATTGAGATAATTGAGAAAAAGCATTTGACAGAATTCAGTATTCTCTTGTGCTACAA ATTTTAAAAAATTAAGTATAGAAGGAATGTACCTCTATAAAATAAAGGCCATATTGACAAACACACT GC TAACGTTATACTGAATGTTGAAAAGTTAAAAGCTTTTCTTTTGAGATCAGGAAGAAAACGAGAATGCCC ACTTTTGCCATTTCTATTCAGCACAGTACCGGAAGTCCTTGCAAGAGCAATTAGGCAAGAGAAAGAAA AGGCATCCCAGTAGGAAAGGAAGACATTGTTGTCCCTGTTTGAAGATGACATGATCTTGTATATAGAA AAACCTAA AGACTCCACCAGAGAATTGTTAGAACTGATAAATTCAGTAAAGTTGTAAGATATAAAATCA AGATACAAAAATCCGTAGAATTTCTGTACATTAATGACAAATTATCTAAAAGAAAAATCAAGAAGACAA TTCCATGTATAATAGGTACCAAAACAAAACATGCAGTGGCTCCCAGTATCAGTGGTTCTGCATTTGC AAATTGAACCAACATTTGGAT GAAAATATTTGAGAAAAAAAATACAACAATAAAAATACTGTTTTCTTATA CAATAAGGAAACTACAGTATAGCAACTATTTACATAGCATTTACGTTGTATTAGGTACTAAGTAATGAT TTAAAGTATACACGAGGATGTGTGTAGGTTGTATGCAAATACTATACCATTTTATATAATGGACTTGAG CATCCATGGATTTTGGTATCTACAGGAGATCCTG GAACCAATATCCTGCAGATACCGAGGGATGATTG TACTTAGAAATAACTTTAACCAAAGAGTTGAAAACTATGTAACATTGATTAAAGAAATTGAAGATGATA CAAATAATGGAAAGTTATCTTGTGTTTATGGATTGGAAGAATTAATATTGTAAAATGTTTTTATTATCCA encenn / Lznz / B / YiAi AAGCAATCTGCAGTTTTAATGCAATCCTGATCAAAATTCCAATGTTAAATTTCAGAACTAGAAAACA GTGCTAAAATTTATATGGAACCACATAAGATCCTAAATAGCCAAAGCTGTCATGAGTGAAAAGAACAAAGCTGGAGACATCACACTATCTGATTTCAAAATATAGTTCAAAGCTACAGTAATTATAACAGCATGATA GTCACATAGAAGTAGACA GGCCAGGCACAGTTGCTCACACGTGTATTCCCACACTCTGGGAGACTGA GGCAGAAGGATTACTTGAAACCAGGAGTTCGAGAGCAGCCTGGGCAACATAGTGAGACCCTGTCTCT AAAATTAAAAAAAAAAAAATTTTAAAGCCAGGCGCGGTGCTGTGTATCTGTAGTCCTAGCTACCCG AGAGGCTGAAGAAGGAGGATTGC TTGAGCTCAGGAGCTTAAGGTGGCAGTGAACTGTGATTGCATCA CTGCACTCCAGCCTGGATGACAGCGTGAGACCCTGTCTTTTAAAAACAAAAGAAACAAAAAAACAGAC ACATCGACCCACAAAACAGAATGGAGAGCACAGAAATAAATTCGTGTACTATCAGTTGATTTTGGACA GGGTGCAAAGAACACACAGCGGGGAAAGGGA AGTCTGTTCAATAGGTGGTGTTGGGAAAATGGAATAT CTACATGCATGAGAATGAAATCAGACCTGTATCTCACATCATATACCAAATTCAAGTTAAAATGGATTAAGGTCTTAAATATAAGACCTGAAACTGTAGAACTACCAGAATAAAGTATAGGAGAAATGTACATGACA TTGGTTTGGACAGTGATTTTTTGGATATGACCCC CTCGAAGCACAGGCAACAAAAATAAAAATTGAT GAATGAGATCACATCAAACTAAAAAGCTTCTGCATGGCAAAAAGAAAAAATCTACAGAATGAAAAAAC TCACAGAATGGAAGATAGTATTTCCAAACCATATATCTGGTAAGGGGTTAATATGCAAAATATATAAGG AACTCAGACATTCCAATAGTAAGAAAGCACCTCACTTAAGAAATGGGCAAAG GACTTGAATAGACATT TCTCAAAATAAGACATACAAATGGCCATTAGAATGGCTATTAAAGTATGATGAGGATTTGCAGACAAG AG ATAT ATTG CGC ATG G C AG G AATGT AAATTAGTAC AG C ATTTATG G AAAATAG C ATG ACGTTTG CTC AGAAATTAAAAAATAGAACTACCATATGATTCAGCAGTCACACT TGGATATATATGTATTTTTATATATA TATATAT ATAT ATAT ATAT ATAT ATAT ATAT ATAT AAATAAAAGAATAAAATCAGTGCGCTGAAGAGATCT GTACTCCCATGTTCCTTTCGGTATCATTTGCAATACCCATGATACAGCATCAGCCTAAGTGTTCATGG ATAAGAAAATGTGGTATGTATACACAGTGGAATATACT TCAGCCATAAAAAGGAGGAAATGCTGTCA TTTGTGACAGCAGGGATGAACCTGGAGGGCATTGTTGAAAGTAAGCCAGCCACAGAAAGGCAAATAC TACATCTCTCTTAAATGTGGAATCTTAACTCAGGGATGTAAAATGGTGGTTACCAGGGGCTGGGGGT GAGTGGACTGGGTTGCAGAGGTGTTGGTCAGAGGACACAAAATTTCAATTAAGAGGAATTTGTTCAA GGTATCTATTGTACAACATGGAAACTAGTTAATAATAACAGTGTATTTTTGGAAATCACTGAGAGTAGATTT TAAATGTTCTG CC ATAAAATAT AAGTATGTG AG GTATTG C ATGTATTAATTAGCTTG ATCTAG CC ATTG CACAGTGTATACATATTTTGGAACATCATGTGAATACAATAAATATGTATCCTTTTTTTGTTTTTTGTG TTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTTTGTCACCCAGGCTGGAGTGTAGTAGCATG ATCTTGGCCACTGCATCCTCTGCTTCCTGGGTTCAAATGATTTCCCTGCCTCAGCCTCCCAA ATACGT ATCATTTTATTTGTCACCAAACCTGGTGTCTTGACAGGTGAAAGGAGATATGAGTATGAGTGAAACT CTTACAAAGATAGCTGAGATGATCATTGTCAGAGGTTTTAGTATGTCTAACAAAGACAAGGGAGTGAT TTGCTGAAATGAGGAGGTGAAGATGTCTCAAATTTAGAAAGGCAAATATTTTGGGGGCCTA GAGTATT GGGATAGAACCATGTACAGGGACATTGAAGTCACTTTGCTGATGATGTAACTGGGGGCAAAGTGGAG GCTTAAATATGTGGGTTTAATTGACCAGAACAGGGAGGGAAAGAGAAGGCATTCGGTTAGATGACAT GAGTTTCAAATTACAAGCTGTTTTTTGTTGTTTTTAATACAGGGAATTTTGCCGTTTATTTT TAATACA GGGAATTAGAAGAATAATGGTGGACTTAGGAGTTTTAGGAGTCACATAAAAGGGTTGCATGATAGGC AGTGCCTTTGGGGAGGAGCCAGGCTTTCATGAAAGCTAAGAAGTTGAGGGGCCATTATGTAAAGTAG encenn / Lznz / B / YiAi TTGAAGATGGGGGATAGCCTATGGGTCTTCAGAAAGCCTCTGGGTTTCTAGAGATCTTTCTGGAAGA GGTTAGGAGGATGAGTCAAGTTTAGAATGGAAGAGGATAGATGAAGCTTGCATTTGGTAGTAAAAAC CAAGGATGAATGTGTGAGGCATGATTATTTGTCACAAGTTTCCAGGTGACACTCTGGCACT CAGTCCT TGTTGAATTAAGCAAGCTTTTCTTACTGTTTTACTTGGCTGTGTTAAAGTAGAGTAACAGGAAATTAGAC TTCCCATAATGTCTCAATAGAGCTGTTTTAAGTTTCTAGCCATAATTGGTATGGGAATATAGCTCTAAA CCTTCAAGGCTGCTACCATTTCTCACATTCCTATATCTAGAAACTGTAGCCAGGCAGCACTTTCAGTG AG GTGAGTGGGTCCAGGTTTGTTCAATTACTTTTGTACCAACCTAATACCTTAATAGTATTTGTCCTAA TTTACAAAAATAGGTAATGAAGGATTCTTGGTTTTACCTCAGAGCTAACTGTCCATTAATGGCAACATC CCACATTTGTTGAAGCATGATTTTGTTGTTTGTACTTTGACATGCATTTGATATTTTAAGTAACGCCTTG A ATGCATCTTAAATAATAATTTATATACAGTTAACACTCCTGTTTGTTTTTAGGAATTCTTAGTGTTGCC AATTTCCTAGGATGTAGAAGAGCATAGTAAAAAAAAAAAATTAATTAATACTCTTAAACAAGTGTTTTTAAC AACTGGACACCATTTTGTAGTTAAGCCTAGAAACAGAACTAATGCAATAACCCAGATCTTTTCATTTAT TCGTATGTTTATTTAC CTGGATTTACTTTAGTTTTTTGTTTTGTTTGCTTGTTGTTTGAGATATTGTCTT GCTCTGTCATAAGTGATACAGCTAGAGTGCAGTGGTGTGATCAGAGCTCACTACAACTTTGAATTCCT GGGCTCAAGTGATCCTCATGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCATGTGCCACCATGC CAGGCTAAACAGT GTTTTTGTTTGTTTGTTTGTTTTTTGTAGAGACAGGGTCTCACTATGTTGCCCAG GCTGGTCTTGAACTCTTGGCCCCAAAGTAATCCTTCTGCCTTGGCCTCACAAAGTGCTGGGACTACA GACGTGAGCCACCGTGCCTGGCCATGGATTTTGTTTAAATTTATAAATACCGTGTTGTAGAATCTCTTT GTATGTATTAA TTTAGACACCTTAGTTTTCTTAATGATTTCATACCAGTTTCTCAGTAACTTCAGATTTTTTTTTGAGATGGAATCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCAATTTGGCTCACTGCAA CCCCTGCCTCCCAGGATGAAGCAATTTCCCTGCCTCAGCCACCCGAGTAGCTGAGATTACAGGCATG TGCCACCATGCCTGGCTAA TTTTGTATTTTTAGTAGAGACAGAGTTTCACCATATTGGCCAGGCTGGT CTTGAACTCCTGACCTCGTGATCTGCCTGCCTCGGCCTTCCAGAGCGCTGGGATTACAGGCTTGAGC CACCGCACCCAACCAGATCAGATTTTTTATGTTTGGTATTTACTCTTTTACCTCTAACACTAAGGCTATG TTTCCAGATGTATAACTATAAATGGA GCAGGGGTAAATACAACAAGTGATTTATGGTTCAGTAAAGCA AGTTAGTTTAATAAATGCTCAGTTTACTGTAAATGTCAGAAATGCCCCAGGACTCTGTCTATTGACAA CTCTTCTATTTCCATCGTCAGCTCTTGCCCTCTGAACTGTAGACTGATTTATCCAACAGTTAAGTCTGG TTCTCAAACTTAACCTGTCCTAAGTGGAGC TCCTGATTTTCATCATCCCAAACCTACGTCTCTCATAAT ATTTTGCCATCTCAGTCAATAACAGCTTTTTTCCCCTCCTGTGCAGCCAGAAGCCTTGGAAGCATCTT TTAATTTCTCTATGTCACATACTCAAATTATTGGTAAATCTTGTTGGCTACACCTTCCAAATACCCATAA TTCATTTTATTTTTTTAACCATTATACTTCTGTTTACTCTGTTTAA AGGCATCATCTTTGGCAAAAGAA AGAAATTGTTTCCCAGGAGTCTTGTGCTTTACAGTGTATTCTCTAGTAGCAGCCGGAATGATCTTTTTA AAATCTGAGTTAAACCATGTTATTTACTATGCACAGAACTTTTCAGAGGCTTCCCATCTTAAAAGTAAA ATCTGGAGATTTACATGGCCCTGTGTGAACTGGCTTCCTTTCATTTCGT GATCTCTCTACCGCACTT GCTCATCTCTGTCTAAAATGGCTGTATCTTTGTCATCTTAAGGCTTGTAACTATTGTCTGTGACCCTGT GACCCTTCTCTGTGATAATCCATGTGGCTTCCTTCCTCACTTGATTCAGAGAGCTCTCTGCTCAAATG ATGCTTTTCCTGACCGGCTGCATCAAAGAATGATCATGTTCTTCTGCAT TCCCCTTAACTTGCTGCATT TTTCTTCATGGGATTTAATGTCATTTGACTTCTTGCATATTGATTTCTTTGTTGTTTTGCTTCTTTACCAC encenn / Lznz / B / YiAi TAGAATGGAAGCCTAATGACAGTGCCTGGCATACAGTAGGTAGTCAGTAACTACTTCCTACATGAAAG AATGAAGCTAGTAAATTTATGCAAAATGTTTGTTTCTGCCTTTTTAATTATCTTGCAGAAATGTAGGAAG AATTTTTAGGATCAGTTTATGTATATATATAAACTGATAAGTATGTACACAGCCTGTAGAATGTGGG T AATACCACCTATCATCTTTTTGAGCATTTACCATGTAGCAAGTGACTGTGCTCCATAATCCACATGCAT TATCTTGAATTTGATAGGAGAGCTGAGCTTTTTAATCAGAGTAGACCATAGAAATATAGCTTGGATGCT TTTATTTCCTATATGACTTCTTCGGTGTACTTACACATCTATAAGCATTTATGGGTCAAGTAACATACTG AAATATT TTCTGAAGTAAAAGAAATCTCTTTAATCAAATAAGTGGTTCTCCTATAGGTTCTCATATCATA TTCTTGGTCTCCAGATTGAGAAGGTCCTTTTGTATGCTTCCAGTATACTCGAAACCAGGAGGTAGTCT GACATCTATTTCCCTTCAAGGTCAAATAATTAGAGAAAGGTTTAATTGACACTGTTATCGAGACAGTAT CAGAAGAGAAATTGAAAAAT CTCTGTTGAGACTCTGTAATTTGCTAGGTTCTGAGGATACGACAGTAA ATAAGTTATTAGGTCATATACCTCAGCTTCCCATTTAATTAATAGGCAGTTATTATATATAATAGAATAG GTACTGGTTGGTATGAGACTACAGAGGAAGAATACCTAATTATTCTAAAAGTGGTATATAAGCTGAAA CCTTGAGGATGCTTGGGAATAGCTAAGAATCATAG TGTTCTAGGCAGGAAGAATAACACCTGGAATC AGAGAAGACAGCAGAACAAGTCCACTGAGTAGTAAGAAGTTCCGTATTGCAGTAATGTAGAGTTAGC TGATGGGAGAAGGTGTGAAAAAATGCATTTGGATATAGAAAGCCAGGAGCACGCTAAGGCCCTTTGC TTTCTTCTGACAGACACAGGAGCCCATGAAAGGCATCAC GTGTGGAAGGAAGTGACACGAGTCATAG TCTGCCCTGCTTTTCTACCACCTGAAGCATCATATAAACCTATATCTTCTGTTTCAAATGTAAGGAAAC ATACTTCTAGTTCACAGTAGGGATAGTTGAATGGATGAACTGTTTCTGGCTGAATCTTCTCAAAGTAG AATGAGCAAAACATGGCTATATTATGAGATTATCTAAGGAAAGATTTTTATAAT CATGTGAATTTTGAAT TTCTTTATATCTTAATTATTCCAAGAGATTTTTGGGAACATTAATGAGAATAGTTTACCTTTAGTACATA GAACTTCTTGTCAGCTATAAATGAGGATCAAACCCAAAAAGATTAACAAAAATAAAAGGGATGCTATT TCCCCAAATTAGCAGAACTTTTTGATTCACCGAGTTCTTTGTTTTTAACTGCTGTCTGCCTCTTAAC AT AATTGAGTATTCAGTGATATAATATAAATAAATCACTTACTAAATGCTGATGAACGCTTGTTTTTACTAA CATCTCAGCTTGTAGCATATCTTGTTGCCCATACCAGAAACCCTACCCATTACCTCTGGCTCTTCCAG CTTATTTACCTCTTACAAACTACTTATTTTAAATATTTCCTGGGTCAATTTCATTCTTTTTTTCTTCCTA CTGCTACATTAT TTGTCCGGACTATTACAGTAGTCATTACCTAACTGGATTGCTTGCCTCCAGTTTTGC CCACTTTGGTTTCAGTTATTGAAAAGGCAAATTTTGTCAGTCACTTAACCTGCTTAAAACCCTTCAGTG ACTCCTTGTGTTTTAGTTCTTATCTAATGGTTTATGAATGTAGTGGGTTACGAATCTTCCGGAAGAGTG CATTTGCACTCCTGAAG TGTGCATGTATTTTTATGAGGAGAAGATCTTTAGCTTTTATTAGATTACTCC TCTTTTGGCTAAAAAAAGAATTACTTATCATGGCTATTGAGGTCTTCCATGATCTGGCTTTTCCCTGCC TCTCCATTTTCATATTTTGAAACTTTTCTTGAACTTTAGGCTCTTGAAGTGCTTGGAATTGTCTTATAA TATCATGTTTTCAGGCCCCT GTGCTTTACTCATTTTCCTCTATCTGAAACATTCTTCCCCTGTCTGAA ACATTCTTCCCACCCATAGTGTCATCAGCTCCTAGTCATCTTTTGTGATTCACCCTTCTCTAAGTTGCCT CTCTTTTTATTGCTATTCCTCTGTAGTCATCTCTGTGATATTGAAATCGTGGCTTTCTCTTTCTTTAGAC ATCATAATTCCTTGAAGAGCCCTTTTTAT GTAGCCTGACAAGCAGAATTTATACTGAAGTAGACATTTG GAAGTCATTTAGTTATTGCTCAATCCTTGAAAGATGAAACTGTCCAAAGGGAAATTTAAAAGGGAAAG TATCTAATAGCTGATCCCTGGAGAATACAAATGTCTCTAGATTTGGAAGGGAAGTCTCTGAAAAACAG CCAGAGAGAAGGGAGGAAACCAAGAAATAGTGTCCTAGA CCCAAAAGTCAATAATTTCCAAAAGGTC encenn / ίζηζ / Β / γίΛΐ TATATTTCTTAGGAAGGCCAAGTAAAATAAGTAGTGAAAAGTGATGACCTGACTAGAGCAGATTCTTC ATTTCCAGTTACAGAAGCTAGGTTATAGGTACAGTAAGCTCTGGACATGTTCTTTTCCCACATGGAAC GTTATTCGTGTTCTCCACTGCTGCTTTGAACTATTCCTTTACTCTCTCAGCATAAAAATCCCTGCTCC TTTGAAGCTTATGCC TTCTGGTTTTGTCTTCCTCTGTCTGCCTTCAGTGAGCTATCAGTTTCTTCTCGG TTTTTGAGGACTGCTACCTGAACTTATTCTTCTTCACTCTTTCCCAAATCTGCTGCCATCTTTATTTATA TGATTAACCCCTCAGTCCCTAGCAAGTCAAATTCCCATCCGTTTTTATCTACAGTAATGTTCACCTCTG CATCACTGCTGCTTCCCATGTCTACAG GCATGCCAACTCAAAACTGTTTTACCCCAAAAGCTTCAGTG AAAACACCTTACCTCAGGTTGCCGTCTTTGAATGCTTTTTCTACTATCTTAAACTTGTTTTCTTTCATTGC GCCTTTTCTTCCTTCTCTTAGAGACTTGTCCTATGGCTCTTCACTGTCTTCCAGCTACAATTCCCTCT TGTTCCTGACATGTACTGCTCAGAGCCAGGAGATGG ATAAGTAGTAGTATTTCACATGCACTTTTTTC TCTGGGGAGCAGTAGTCATACAATAATTGATTAAGATAAAACAGGTTTTTATCAGTTTATATAAGAGGT AAAGAAAACAATGGGGTAGAGTTTTAAAAATTGTCAAAAACAACACATTTTACCATATTAATGATTTGAAGTGTACGGTACAATTGTGGTAACTGTGCACATTGTTGT GCAGCAGATCTCTAGAACTTTTTCATCTT GTAAAACAGAAACTCTACATTCATTGAACAACTCTTCTTTTCCCCCTTCTTCCTATTCCTTGGCAAATG CCATTCTACTTTTTGCCTCTAAAATTTGACTGTTTTGGCTACTTCATGTCAGTGGAATCATTAAGTATTT GTCTTTTGTTGACTGGCCTATTTCACATAGCAATGTCCTCAAGGTTCATTTGTG TTGTAGCATATTACA GAATTCTTTCTTTTCTTTTAGGCTGAATAACATTTTGTTATATATGTATACCACATTTTCTTTAACCATT TGTTGATGGATGTTTAGGTTCCTTCCACTTCTTGAATATTGTAATGTTGAAATAAACATGGGTATACAA ATATTTTTTGAGAACCTGTTTTTAATATATTTGGAAGTATACCCAGGTGTAGGATTACTG GATCATATG TATTCTATTTTTTTTTAGATTTTTTTTTTTTTCAGGAGTTCTAGGTTCACAGAATTGAGAGGAAGGTA CAGAGATTTCCCCTGTACCTCCTTCCACACACATGTATGGATTTCTCATAGCCAGTGTGCATCTCCC ACCAGAGTGGTACATGTCTTTCTGATGAACCTATATTGATACATCATAATTACCCAAAGTCCGTAGTTT ATA TTAGGGATCATTCTTAGTGCTGTACGTTCTGTGGCTTTGAACAAAGTACAATGACATGTATCTACC ATTATATCATACAGAATGTTTTCACTGCCCCAAAATCCTCTGTGTTCTGCCTATTTATCTTTCCTTCCCT CCCACTCCTTGGCAATCACCGATCCTTTTACTGTGTCTCTAACTTTGCCTTTTCCAGCATATTATATAC TTGTAATCATACAGTA TATAGCCCTTTCAGCTTGACTATTTTACTTACTAATATGCATTAAAGTTTCTT CCATGTCTTTTCATAGGTTGTTAGTACCTCTCTTTTTCCATTTTCTGGACATATCACAGTTTGTGAATGA ATATTCACCTAATGAAGGACATTGTGGTTGCTTCCACATTTTGCTAATTATGAATAAAACTGCTGTAGA TATCGGTGTGCAGGTTTTTTGTG TGGACTTAGGTTTTCAGCGACTTTCTGTAAATACTAGGGAGTGCAA TTGCTGGATCTTATGGTAAAAGTGTTTAGTTTTGTAGGAAACATCCAAACTGTCTTCTAATATGACGCT ATCCTTTTACATTTTTCACCAGCAATGAGTGAGTGTTTCTTTTGCTCTACATCTTCACCAGTATTTGGT GTTATCAGTGTTCTGAATTTTG TCCATTCTGATAGGTGTGTAGAGGTATCTTATAATTTTAATTTGTGTT TCTCTGATGCCATATGATGTGTGGGACATCTTTTCATATGCTGAATTGCCATCTGTATATCTTTGGTGA GGTGTCTGTTAAGGTTGTTGGCCAATTTTTTAATTGGGTTGTTTGTTTTCTTGTGGAATTTTAAGAGTT CCTTACACTG TCTCTGTCTGTCTTGTCTGTCTGTCTGTCTGTCTGTTGAGACAGAGCCTCGCTCTGTC ACCCAGGTTGCAGTACAGTGGCACAGTCTTGGCTCCCTGCAACCTCTGCCACCTGGGTTCAAGTGAT TCTCCTGCGTCAGCCTCCCGAGTAGCTGGGATTATACCCGTGCACCACCACCCTGGCTAATTTTTG TATTT TTAGTAGACACGGGGTTTCACTATGTTAGCCAGGCTGGTCTCGACCTCCTGACCTCAGGTGAT encenn / Lznz / B / YiAi CCACCCACCTTGGCCTCCCAAAGTGCTGGGATGTGAGCCACCACCCAGCCTCCTTACACATTTTAGTTTAATAGTTCTTTATCAGATGTGTCTTATGTAAATATTTCCTCCCTATCTGTGGCTTGTCTTTTCATAC TCTTGACATTGTCTTTTGCAAAAGACAACAATTTTTAAGAACAAGTAGACAATTTTAATGAAGTCTGG CTTA TCAGTTCTTTCTTCATGGTTGGTACCTTTGGTGCCGTATCTAAAAGTCATCACCAAACCCAAGA TCTAGATTTTTTTCTTATGTTATCCTCTAGGAGTTTTATAGTTTTGAGTTTTACATTTAATTCTCTGGTTTA TTTTGAGTTTATTTTGTGAAGGGTGTAAGACCTGTGTCTAGACTCTTTTTTTTTGCATGTGGATGTT CA GTTATTACCACTGTTTATTGAAAAAGACTATTTTCTTCATTGTATTGCCTTTGCCTCTTTGTCAAATA CTGCCATTGCTCCTTTGACTATGTGGGTCCATTTCTGGGCTCTCTATTCTGTTTCGTTGGTCTGTTTTG TCAGTTCTTTTGTCAGTACCACACCATCTTGACTACTGTAGCTTTACAGTAAATCTTGAAATCAGTAGT GTCC ATCTGACTTTTTCTGTCAATATTGAGTTGTCTCTCACGGGTCATGGAATAGCTCTTCATTATTTA GTTATTTGATTTCTTTCATCAGAGTTCTAAACATTTTTCTCATATATCTTGTACTAATTTTGTTAGATC TGTACTTAAATATTTCATTTTGGGACACGCTAATGTAAAATGGTATTGTGTTTTTAATTTCAAATTCAAC TTATGCATTGCT GGTTTACAGGAAAGCTATTAACTTTTTTATATGAACCTTGTATCCTGCAGCTTTGCT ATAATCACTTATTAGTTCTAGGAGGTTTTTGTTGTTTTTCTTTTTCTTTTTTTCAATTCCTGTCTATGTTC TACACATATAGTCATTTCATCTGCAAACAAAGGCAGTTGTATTTTTTTTGTTCCCCGTTAGTATACCCTTT ATTTCCTTTTCTTGTC TTAGCTAGGACTTCCAGTATGGAGTGGTGAGGTGGGGATATTCTTTTCTTGTT CCTGATCTTAGTAAGAAAGTTTCTAGTTTCTCATCATTAAGGATGGTGTTAGCTGTATGTTTTTTGTAAA CGTTCTTTATCAAGTTGAAGGTGTTCCCTCTATTCCTAGTTTACTAGTTTCTATCATGAGTGGGTGTTA AATTTTGTCAC ATACTTCTCTCCATCTATGGTATGGTCATGTGATTTTTCTTCTTTAGTCTGTTGATATG GTGAATTGCATTAATTGATTTTCCAATATTGAACCAGTCTTGCATACCTGGGATAAATCCTACTTTGTG CTGGTGTATACTTCTTTTTATACATTGTAGTAAAATTTAGTTTGCTAATACTTTGCTAATACAAAGATTTT TGCATCTTTGTT CATGACAAATATGGGTCTGTAGTTTTCTTTTTCTGATAATGTCTTTGTCTGGTTTGGG TATTAGAGTAATGCTGACTTCATACAATGAGATAGGAGCATCTCCTTTGCTTCTGTCTTCTGAAGGAG ATTGTAGAGAACTGGTGTGGTTTCTTCCTTAAATGTTTAGTAGAATTCATCATCAGAGAATCCATCTGGGC CTGATGCC TTCTCTTTTAGAACATTATTAATTATGGATTTAATTCTTTTAATATATGCTTTTTAATCAAGA TTATTTCTTCTTAGAGTTCTAATAGATTGTGTCTTTTAAGGAATTGATTCATTTCATCTAGGTTACCAAA TTCGTGGCCGTAAAGTTGTTCATAATATCCCTTGATTATCCTTTTAATGTCCATGAGATCTGTAATGAT GTCCACTCTTTTCATTCTG ATATTAGTTATTTTGTCCTTTGTCTCTTTTTCTTAGCCTGGCTAGAGGCTT ATTGATTTTATTGATCTTTTCAGAGAACTAGTTGATTTCTTTGATTTTTCTCTATTGATATCTTGTTTTCA ATTTCATTGATTTCTGCTCTAATTTTTATTACTTCTATTTGGATTTAATTTGCTTTTTCTAGTTTCATAAGT TGGTAGCTCAGATAATTGATTTTTAGATCAT TCTTTTCTTTTCTTTTTTTTTTGAGATGGAGTCTCGCTT TGTCGCCCAGGCTGGAGTGCAGTGGCTCGATCTCGGCTCACCGCAAGCTCCGCCTCCCGGGTTCAC GCCATTCTCTTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGCCTGCCACCACGTGTGGCTAAT TTTTTTGTATTTTTAGTAGAGACGGGG TTTCACTGTGTTAGCCAGGATGGTCTTGATCTCCTGACCAT GTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACAGCGCCCGGCCTA GATAATTCTTTTCTAATAAATGCATCAGTGTTGTATGTTTCTTTCTAAGCGCTGCTTTCACTGTATCCCA CAAATTTGGATAAGTTGTGTTTTCATGATATTTTCAATTT ATAATGGTATTGGGACACAACCCAATAAGT AAGTTTAGGAGCATTTGTATGCATAAGCACAATTGTTGACATTATTTTGAACAAATTCTTATTTGTTAGA encenn / Lznz / B / YiAi TCAATTAAGTATAAAAAAATAAAAGGTTTTATTTTACTTTCAGTGTTTCCTTCTTTTGATGCTCTATATA TGTAGATTTCAGTTTCTGAACTTCCCAACACTTATTGCAAGGCAGGTGTACTGACAACAAATTTCCTTAATTTTGTCTGAGAAAGTGTTTCTTTTTAACTTTTGAATAATAATCTCACAAGGTAGAGTGCTAGGTTTA TGGTTTT TTTTTCTCTCAACACTATGAATATTTCACTCTTTTTTCTTGTTGGAAGTCACATGTATTTTTTCT TTTTTTTCTTTTTTTCCTCTACAGGTAAGGTGATTTTTTCCCTCTGGCTTACTTCGGATTTTTTCTTATC CTTGAATTTCTGTAATTACAACGTTTTATGCCCAGATGTAGTTTTTTGGCATATTTTCAAGCTCAGAGAT TCTTCATCCATGCCCAG CCTACTAATAAGCCCATCAAAGGCATTCTTCATTTCTCTTACAGTGTTCTGT TTTTTGTTTTTGTTTGTGTTTTATCTCTAGCACTTCCTTTTTGGTTCTTAGGATTTTCATCTCTACTTTTTT AACATGTTGTTTACTCAGTTCGTTAGGGCCCTTAGCATATTAATCATAGTTGTTTTAGATTCCAAGTTT GATAATTCCAAATCCCTGCTGTA TCTGGTCCTGGTGCTTGTTTTTTACCTTTTATTATGCCCTGTAATTT TTTTCTTGATAGCTTGGACATGATGTACTAGGTAAAAGGAACTGTTGTAAATGAGCATTTAGTAATGTG GTTGTAAGGTGTAGGGAGAGGAGAAGAGTTCTGTAGTCTTATGATTAGGTCAGTCTTTTTAGTGAGCT TATGCCTCTGGACTGT GAACTTCACAAGTGTTTCTCAATCCCACCCCTCCCTCATTCCCTTAGTTAGA ACAAGATAGCTATAATGGCCTGAAGTTGGGTTATTTCTCTTCCCCCACATCATTTTGGCTTTGCTACAA CCCCAGCAGGTTAGGCTCTGGTTAACTAGTTTCTCCTGAGGACAAACCTTGTTAAGACTGGAATAGTC TAGTGTACTTGAAAATCATTCTCTTTGCC TCCCCTGCTGAGGGTTGAGGATTTTTCTCCTATATTTAC TGTGAGAAGCTGGTCAATTGCCTGGATGTAAAACTTAGAAAATTGTAGGGCTCCCCCTATAATTGGGT AACTCTGGAGTTTTTAGCTTTCAGAGTTGTCCACACTGAGCCTTCATCAATTTGTCTATTACACTTCAGGATTTCCTACCCCGTGGAGGTTTCTGCTTG TGTTTTTCATCTCAGATAAATGGTGATGCTATGTGTTCA CCTGTTCTCTGCTCTCACAGGCAGTCATTTGCCCTGTGACCTCACTTATCCTATCTCAGATTTGTTTAT TTTTAAGTTTGTCATTTTTACTTGTTGTTAGGATGGAGTGGTGACTTCCAAGCTCTTCATATGTGGAA CTGGAGGTAATTCTATTTCAAATT TTTTGAGGGACCTTCATGTTGTTTTCCACAGTGCCTGGCACCATT TTACATTTTCACCAGTGGTGCATAAGGGTTCCAGTTTCTCCATATCTTCACCAATACTTATTTTCTGTTT TTTTAATGGTGGCCATCCTAATGGTTTCAGATGATGTATCATTGCAGTTTTAATTGACATTTCTCCCTA CTGATCAGTGATGGTGAGAAT CTTTTCATGGGCTTATTGCCCATTTGTATATATTCTTTGGAAAAATGA CTATTCAAGTCCTTTGTCCACTTTTTAACTAGATTTTTTGTTGTTGAATTGTAGGAGTTATTTATATATTC TGGATATTAACCAAATAACAGATACATGGTATAGAAATATTTTCTCCTGTTTTGTAGGTTGCCATTTTAC TCCATTTACTGTTTGCTTTGTAGAA ATTTTTGAGTTTATGTATCCCCAGTTTGTCTATTTTTGCTTTGGT TGCTTGTGCTTTTGGTGATCTATTCAAGAAATCATTGCCAAGTCCAATGTCATGAAGCTTTTTCTCCAT GTTTTCTTGTAGTAGTTTTATAATTCGATGTTTTAAGTTTAGGTCTGTAATCCAGCTTGAGTTCATCTTT GTATATGGTGTGAGATAAGG CTCCAACTTCATTCTTTTTGCATGTTAGATTCCAGATTTCCCAATACAGT TTGTTGAAGAACCTCTTTTCCCTATTTCTGTGTTCTTCTCTTCTGCTCACTTGGTCTGTATATCTGTCTTT ATGCCAGCACCATAGTGTTTTGATTACTATAGCTTTGCAATATCTTTAGAAATCAGGGAATGTGAGGC CTCTAGCTTTGTTTTTTGTCCAGA TTGTTACGGCTATTCAGGGTCCTTCAAGATTCTGTATTAATTTTAA GATTTTTTTTTTCTGTTTCTGTAGAAAATGCCATTGGGATTTTGATAGGGATTGCTTTGAATTTGCAGAT TGCTTTGGGTAGTATTGCCATCTTAACAGTACTAAATCTTCCAATTCATAAACTTGGATGTCTTTCCATT TATTTGTATTGTCTTTAATTTTCTTCA GCATTGTTGTATAATTTTCTTTTTCTTTTTTTTTTTTTTTTGAGA CAGAGTCTCACTCTGTCACCAGGCTGGAGTAGAGTGGCGTGATCTTGGCTCACTGCACCTCTGCCTC encenn / Lznz / B / YiAi CCAAATTCAAGTGACAACTCCTGCCTCAGCCTCCCGAGTGGCTGGGATTACAGGCGCGCGCCACCA AGCCCAGCTAATTTATTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGATGGTTCCA ATCTCTTGACCTCGTGATCAGCCCACCTTGGCCTCCCAAACTGCTGGGGTTACAGGCGTGAGCCACC ACG TCCGGCCTATGTTGTTTAATTTTCAATGTACATGTCTTTCATTTGCTTGGTGAAAATATTCCCTAA GTATTTTTTACTCTTTGATTTCATTTTTAAATGGGTTTAAAAAATTAATTTCCTTTTTGGATTCTTCATTTTTT AGTATTTAGAAATGCAACTCTTTTTCTTAATATTGGTTTTTATATCCTGTAACTTTACTGAATTCCTTTATT CTAACGGTTTT TTTTCTTTTTGGTAGGCTAGAGTTTTCAACATAAAAGATCATGTCATTTGCTAACAGAA GTAATTTTACTTCTTACTTTTCTCATTTAATACCTTTCATTTCTTTTTCTTGCCCAGTTGCTAACTCTGGC AGGATGTCTAACAGTATGTTGAATAGAAGTGGTGAATGTGTGCATTCTTGTTCCATTTGTGATCTTAGA GGGAAAACTTTCAG TTTTTCATCATTGAATAACATTAGCTGTGGTCTTTCTATATATGGCCTTCATTATG TTGAAGTAATTTCCATATCTTTCTAGCGAATTGAGCGTTTTTTGTTTTTGTTTTTTTTGAGACAGAATCTTG CTCTTGTCACCCAGGCTGGAGTGCAATGATGCTATCTCACCTCACTGCCAGCTCCGCCTCCCGGGTT CTCAAGTGATTGTCCTG CCTCAGCCTCCCGAGTAGCTGGAATTACAGGCGCCCACCACCATGCCCGA TTAGTTTTTGTATTTTTAGTAGAGACAGGGTTTCACTGTGTTGGCCAGGCTGGTCTCACACTCCTGAC CTCAGGTGATCCACCCACCTTGCCCTTCTAAAGTGCTGGGATTACAGGCATGAGCCACCCCTGTCTGG CCTTTTTTTAAAATCCTAAA AGGGTGTTGATTTTTGTCAAATGCTTCTTCTGAGTCAGTTGAGATTATTGG TTTTTGTCCTAAGAATGCAGTGTATTAAAGTGATTTTTTGTATGTTGAACCATCCTTGGATTTTATGAA TAAATTCCAGTTGAGAATTTATGAAATATAATCTTTTAATGCATTGTTGAATTCTGTTTCTTGGTATTTT GTTGATTTTTTTTGCATC AGTATTTATTAGGGATTCTTTTTTCTTGTAAATTTGTCTGATTTCGATATCTA AGTAATGCTTACCTCATAAAATGATTTTGAAAGTGTTCTGTCCTCTAGTTTTTTCAAAGAGTTTGAGAA GGGTTGTTAGTTTTTAAATGTTTGGTAGAGTTTTCAGTGAAGCCCTGGCGTTGTTGGACAGTTACTGA TTCAATCTCTAATAGTTATAGGTC CATTCAGAAGTTGTATGTATTTGTGGCTCAGTCTTGGTGGGTTTG ATGTGTCTATCCGTTCTCAAAGGTTATCAAATTTTTTTTGGGTCATAGTTGTTCATATTAGTCTTTTAAGG TCCTATTTATTTCTGTGGCAGCAGTTGTTGTATCGCCTTTCTAATTTCCAGTTGTTGCTGTTTGTGTCT ATTCTCTTCAT TTCTTAATCTAAGAATTTGCCAGTTTTGTTGATCTTTTCAATAAAACAGCTACTCCTAA TTTTGTTGATTTTTTTCTATTGCAAAATTTTCTATTTTTCTCTATTTTATTTTAGCTGTAATTTATTTTTA TTTTTTTTATTTTTTGGTAAGTTTGAGTCTCATTTGTTCTTCATTCCTAATTCCATAAGATGTAAAGTTAATTTGTTGATTTAAGGTTTTTC TTCCTTTCTAACTGTGAAATATGACACTGTAAAACAGATTTTCATTTTA CAGATGAATTATGTAAATATTTAGTTCTACAATTTTACTTTTTTTTTTATCATATATCACGCATTCTGGAT ATTGAGACTATAAAAATGAAAAAAAACAGTTCTTTCTTTTCTTTTTTTTTTTTGAGACAGAGTCTCGCTC TTTTGCCCAGGCCACAGTGCAGTGGCTCTG TCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCAT GCCATTCTTCTGCATCAGCCTCCCAAGTAGCTGGGACTATAGGCGCCCACCACGGCGCCCAGCTAAT TTTTTTTTGTATTTTTAGTAGGGACGTAGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCT CATGATCCGCCTGCCTCGGCCTCCCAAAGTGCTG GGATTAGAGGCGTGGCGTGAGCCACTGCACCC GGCCATAAAACAGTAATTGAAGGTTAACCTATATTTCAAACAACTGAAAATACTGATTTGTTCATATTTA TTTTTTCATGAAAATCGTCTTGTTCTATATTTAATAGGTTTTGTTCGGTTCATGGTACTAATGAGTTCA CAATTGTAGGTTTAGTCTTGAAATAATCTAAATTCACTTCATCCCATT GTAACAGACCCTACATCATACT GAATATAGTTGTGTCACAGATGTCTCTTACAGTCTATTTCTACAAGGCCTAGAACTATTTAGGATACCG encenn / Lznz / B / YiAi TTGCTCACTCTTACAAATTTTAACATTAAAAATAACTTTGAGATGGAATGGAGTTTTGCAACGTCTCAG AACAAAGAGACTCCACTTACGAGAAATTACTAAGCAGTGGTTCCTAGCTTTATAGACTAATTATATAAG CCTTCAGTTGTTTCTATTTTATATCTGTTTTTAGATTCCTCACATGTTCATTCTGCTTTACCTTCTGTAT AATATAAAGGTC ACTCTACTTACAGTCACATTTTCCTTTTAATCTTTCCGTTTTTATTTTTTATTCTTTGC TTTGTTCACCATTAGTTTTTATATTGCATCTCACAGTTCATGTTTCTTTTTTGTCATTTCTGATTCTAATT GTAATTCTAATCTTACTTGTTTGGCGTTCACTGTCACATCTTCACTTTCTGGCAGCTGTTTCTATGGCT TCATCTTCTTAGTGCTTGTA TTCATTGCTTATATTCCAGTTGTCTTGTAAATTCATTTTTTAGTGAACTA AGCCAGACACGGAAAGACAGATATCACATGTTCTCACTGATATGTGGGAACTAAAAAAACATTGAACA CAAATTTTACAGCTGACACACATATGCCTGCCACCTAGATTCTGCCATTAATACTTACATTGCTTTATC GTATAACCATCCTTGTATCCATCAATCCATCTTA ATTTTTATGCCTTTCAAAGTTAATTGCTAACATTAG TACACATCCCTCTAGGTGAAACCATTTTAAACTGATTGCTGTCAAGTTGTCTAGAGTAAACTCTGATC TTCCAAGTATGACTTATTCCATAGGACTTCTGTTTGTAGCACTGTCCCATTAATTCAATCATAGAAATA AATAATTGGAAAGTATTGTCTGTTTTAAATGGATAAGTATTTTCATG TGTCTGACTTTAGAGGACTTTTA CTAGAAGGTCTCACTTGACCTTCATTGCTGACTAAATAAGAAAAGTTTGTTTTATTTTAAAAATCAACAC ATTATAACATACTTTGTTTTTTGAGTAATAAGAAAAGTCAATGGAATGTGAAGAAATTATAGCAAGTAA GCTGTTGTTCCTCTTCTAGGAATTTTGATTATGAACAGCTGATAAGGTATTACTAAGGGATC TCATCAG GGAAATTCCTTTCTTTCCTTCTTTTTCTTTTGCATCCTCTCCCTTTCCTCACTTTCTTTTCCCCTTTTTCC CTTTTCCCCTCTCCTCTTCTTTTCTTTAATAGTACTTGGGGAAAGGTATACCTTTTATTTTACGGATTTG CTCAGGGTAAAGAGAGAGTTAAGAGGCCAAATGATTAGATGGCAGGGTCACTGGAGGGCAGAGATA AATAATA GATCCTAAACTAAGGGTTGGCAAACATTTTCTGTAAAGGGCAGGTGGTATTTGTTTTAGGTT TTGCAGGCCTAAAGTACTCAACTCTGCCATTGTAGTATGAAAAAACAGCCATAAACTATATAGTATATTG TATTAGTCCTTTTTCACGCTGCTGATAAAGACGTACCTGAGACTGGGAAAAAAAAAAAGAAGTTTAATTG GACTTACACT TCCACATGGCTGGGAAGGCTTCAGAATCATGGCGAAAGGTGAAAGACACTTCTTGCA TGGCAGTGACAAGAGAAAATGAGAAGGATGCAAAAGCGGAAACCCCTGATAAAACCATCAGATCTGTGAGACTTACTACCACAAGAACAGCATGTGGGAAACTGCCCCCATGATTCAGATTATTCTCCCAGGGG GTCACTCCTACAACACATGAGA ATTATGGGAGTACAATTCAAGATGAGATTTGGGTGGGGACACAGA GCCAAAGCATTATCATATATAGTATATTTATAAATCAATGAACTTGGGTATGTTCCAGTACACTTGATG GATACTGGAACTTGAATTCTTATAATTTTCACGTTACAAACTATTATTATTTTTCAACTTTTTCCAGCC ATTTAAAAATGTAAAATATTCTAAGCTTGAGA GACATAAACAGGTGGTGGACTCGATTTGACTTACGAG CTATGATTTGGTGACCCATATGGTACAAGGATTTCCCTTGCGCAGGAACTATACCAAAAAGTCGTTAT TAGTGTATACTTTTCCAACGTAGAGGCCCTTTTATGTGCTCTTAAATTTTGTATGCCTTTTACATATCCTA AATTAGATAGTGATGCAGATGAGGTCAGATAA ATTAAGGTGTCATTGGAGTGAGGAAAAAAGAAGAAT GCTTAATATAGTTGATTCCACCATTAACTTGGAGGTTCTGGCATGGCTTCCTTTAGTCCTGTCTCATCA GTGTAGCTGCTATTTGTTAAACTTGGCACAGAAAGGCAGATCAAATATAGAGGGCTACTTTCAGATCC TCCTCTTAATAGTTATTAAAAAGCTCAAGTTTAGTAGCTGA GTTCAAATCTCTTATTAGATGTATGACTTA TGTAATTTCCTGAGCATCAGCAGAATGAAGGTTTATAGTGCTAACTCATACACTTGTGAGGGTGATA GTAACAATTACAACAATAATAGTAGTAGCTAACACTTTCATAGTGCTTAGTATGTGCCAGGCAATGTTC TAAGCACTTTATATATATTAACACATTTAATTTTTCTCACAATTGG TAATGTGAAGAAGAATAATACTCTC rncrnn / Lznz / B / YiAi ACCATGATAATGCTCGTAGATACTACCATTTAAATTACGAGGAAACTTACGTCCAGAAAGATCAAGTAA TTCATTCAGGGTCACATAGTTAATTAAGAGGTAGAGCCATTATGTGAACTTGGGCATCTGGCCTCAGA ATGCGAGCTCTTAACTGTTAAGGTTTATTCCCCTCTAAAGTGGGAATGTCTATAAAATGCATAGCACAT AG GTCCTCAACAAATTAGAGAGAAATTAACTTTGCAGAATATAGTGGTTCCATTTCTCAAGAAACTTG GTCTGCCTTTGTGGTACCAGATAGATGCATAAATGTGAGGTTCACGTTATGATTCTTCAGATTTTTTTC CCAGTTGCACATTAGTTATGAGATTTTTTTCCATAGAATTCTTCAGTATTACTCATGTTAAAAAAATAATT ATTTTGAAATGAAT CACCTTCTGCAAAACAATATAGTCAAAATGACTTAGACTCTGAAGCTGAAAGACT CCTGGACTCCTATTCTTGTCTTGGTTCTGTACTTTCTTTGAGATCTTGGTTTCGTGATTTGACTCCAGT TCTATTTCTCTCTTTGGCTGTGGACTGAAGATAATCCTCAATGTCATGGTATTCAAATGAGATAACCCA TGTCAAAGTGCCCCGCAGT GTGTGTAATAAGTTATCAGGCATCCAGCAAATACTAGTTTCTTGCTCAC CTCCCTATTACATAAAATAACTTTTAAAATTAGAACTGAAGGGACTCATAAAGCTGGGAAAACTGAGGC CCAGACAATTGTTTCCCTAGGATCCTACAGCTGCTTAGGGACAGAAGGATGACACTTAATGCAGATCT TCTGATTTTTCAGTCTCGTTCTGTTTGTGCTGA TCACTCTCCTCCTATGTAGTATATAAAGAAGTACTAT GTATCTGACAAGTTTTGGGGAGGTTATTTAGTATAAAAGCTCACATTAAAAATATCTATTTTGGTATTT TGACTTTTGTAATTTTTTAAAAATCAGAGACAATTTAGTAAATCTCGGGGCCATTCAAAATCATGTATAT GAAGTTTTATAACTGCTATTGTTTTCCCCTTATAGTTATTAATTTT TAATATGCAAGTAGCATCCTTACT ATGGAAAGAATAAATAAGAAATCAAAAGATGGAAGAAGTTTTAAAACTCACTTAATCACATCATCCAGA GAAAATGCTATTAATGCTTTGAAATAACAATGGGTTCATCCTACACCTGCTACTTTTTAACTGACTTTT GTCAGTTAGTGATATCAGGAAGACTAGGCAGTTCTTTGTCGAATTCAAATCTTGATAGTT TTTATTT TATTGTGTGACCTATTATCAGTTCATTTAAGTAATCTTTTATTAGACATGTTTTTTTCAGATATAGAAACA ATGCATTTTGTAAAATTGTCAAATTATTTTCCACAAGTAGGATCTCATTCACACGGTATTCGTGTTTT AAGACTTTCGATACATGTTCACTGTTTTCCTCCAGAAAGGAAATACCTACTTACATTTTCACCAGGGAA G TCACTGTAGTTTGGGAGAACATGACATTATCTCCCTTTCTTTACTGAAGGGTAGCAATATATATTTTA AATTTTCTAGATTCTGCATTTCCATTTTATTTTTCATGTTTTCACTTTCATATTTTGCATAGTGCTAAAT CTGTGATAACAGTTTTTAATTTTCAGGTGGGGTTTATAGCTTCATAGATAGCAAAATGTCTTTAAGTCA TGTTTATG CAATTTTACATGTGCTTTGTGGGTTTTCTTTTTCTCTGTTTGCATGCAGTGAGTGGTAAA TTTGCATGGAACATTTGAAAAATAAGCACCAGAATGAATTGAATGTGTGTGAATTATCACTTTTTGTCA CCTACCTGGACAGAGAGTGAAAGTTCTTCTGTTGAGACAAAATTGGATCTCGTGTGTTTCTTCACTTA CTTGCTGCCTTGTTAATTGTTGAGTTTCTCATGATTAGCAAGATGTAAACTCTGGCATTGGTCATCTAG TCCTACATGTTAGATAATTCTGTGAATGTTTTGAAAATCAGCTGAACTATTTTCTTATAATTTTGATTCT TTGTAGTTGTTATTTCCATGCTTGTGAATTTGGGACCAAAAAGGAATGGCTATGACTTATGTTTCTTTGG ATCCAGTAGTTTATTCTACTGAAATTATGGTAATTTATCAGTTAGTAGAAGCATAGACTCTTTAGTGTT GAATATAATGTCATCTAACTTCTTACATGGTCACATAATTCCTCCCTCAGTTTTGGTAGCTTCCCTGAA ACAGCCATAATAGGACATTAATCTGTGTACTTTAAGTTGACAGAGTAAAAGGAATATAAGATTTCACGTGATGGAACTTAAAATATT CCATCTTGTGACGTGGAACTAATGAGGAGGTTTAGTGACAAGTTTTAGATT TAAGATTCTACACTTTGGAGCCTCTTTTTCTTTTTCTTTTTTTGGTTTTGTTTGTTTGTTTGTTTTGAGAC AAAGTCTAGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCAATTTCAGCTTATGGCAGCCTTGACTC TCAGG CTCAAGTGATCCTCAGCCTCCCAAGTAGCTGGGACTACAGGTGCATGCCACCACACTTGGCT encenn / ίζηζ / Β / γίΛΐ AATTTTTTTAAAAAAGTTTGTAGAGAGTAGCCTCACTATGTTGCCCAGGCTGGTGTTGACCTCCTGG GCTCAAGTAGTCGGCCTGCCTCAGCCTCCCACAGTTATGGGATTGATTACAGTCATGATCTGCCTCA CTCAGGCTGCAGCCGCTTTCTTTCAGTGTAACACTATCTTTGGATATTCCACTTACAAATTTATTTTTAA GTCTC CCATGTTGTTGATAATTGGGAAAAATAGTTTTTATTCCAGATAGATATTCTGTGTTAACTATAAG TCAAATGTTTACAAGCTGTTAAAAATGAAATACTGATTATGTAAAAGAAAACCGGATTGATGCTTTAAA TAGACTCATTTTCCTAATGCTAATTTTTAAAATGATAGAATCCTACAACTCTTAGCTGTAAACCTTGTGA TTTTTCAGCTGTTGTAC TAAACACTTAAGCACATATACCATCAGACAAGCCCCCCTCCCCCCTTTTAA ACCAAAGGAATGTATACTCTGTTAATACAGTCAGTAAGCATTGACATTCTTTATCATAATATCCTAGAAAATATTTATTAACTATTTCACTAGTCAGGAGTTGTGGTAAATAGTGCATTCCCATTTTCTACTTCTCATC TTCATACACAGGTTAATCACTTCAGTGCTTGACTAACTTT TGCCTTGATGATATGTTGAGCTTTGTACT TGAGAGCTGTACTAATCACTGTGCTTATTGTTTGAATGTTTGGTACAGGAAGCGAGCAGCTGCAAAGC ATCTAATAGAACGCTACTACCACCAGTTAACTGAGGGCTGTGGAAATGAAGCCTGCACGAATGAGTTT TGTGCTTCCTGTCCAACTTTTCTTCGTATGGATAATAATG CAGCAGCTATTAAAGCCCTCGAGCTTTAT AAGATTAATGCAAAACTCTGTGATCCTCATCCCTCCAAGAAAGGAGCAAGCTCAGCTTACCTTGAGAA CTCGAAAGGTGCCCCCAACAACTCCTGCTCTGAGATAAAAATGAACAAGAAAGGCGCTAGAATTGAT TTTAAAGGTAAGATGTTTTATTTTTCAATTGAGAATTGTTGCCTGAAAACCATG TGGGAGATTTAAATGT ATTAGTTTTTATTTGTTTTTTCTTCTGTGACATAAAGACATTTTGATATCGTAGAACCAATTTTTTATTGT GGTAACGGACAGGAATAATAACTACATTTTACAGGTCTAATCATTGCTAATTAGAAGCAGATCATATGC CAAAAGTTCATTTGTTAATAGATTGATTTGAACTTTTTAAAATTCTTAGGAAAAATGTATTA AGTGGTAG TGAATCTCCAAAACTAGGCCACAACATCTATTTAAGTTATAGAATAACTGGACTAAGTATCTGGCATGA GTTCTGGAACCTCAGGATGATGTGATGAAAGAAGCAGAAAGAGGAAACAGTGGGTTTTTTCCATTTT GAAGGCAAGACAAAATTTTGTGATAGTTATGTGAGAATTCTACGTTTCCTTCAGATATATGCTTCTCAC TCTCCTTCCGGACATTTGGTACAGTCATGCTGCCAAGGATCATGACCTACCAATGACAGTCTTCACTC AGGTCTTTTGTTTTCTAAATGGTCCTACGTCCAAAATTCAGAATTCGATTACCTTGTCGCTAATACTAA AACTCCAAGTTATTTTCTTCAGTGAAGGTAATTAGTAACAAAGTAATCAAATTTTTGAATGACTACCAG GGCTTAGCG CCCCTCCACTCTCACCCCTACACACACCCAGAGGCAATTGTATTTTAAGAGAGAAAGC TTTTTTTTTATGACATACAAGTCAGAGAATTTTAGAGGCATTTGCCTCTAAAACTTTCACTAACATCATT TGAATCAAGTTTGAAAGAATTAGTGAAGTGGCATTGTGTTATAACCTCTACTCTGTTTCCACAATAAAA TTATTTCGTCACTTTACACAACTTTG TTGCTTCAGAGTGTATAATTCTGTTTCATGAATTAGTTCACAC ACTATGGGAAAATAGGTAAATGTTGTCTGTATATATAGTGTGTCAGTATAATGTGGAAGCTGCATTGA CTTTATTGTACACAGTTCTCCAGTAAGTGTGCACCAGAGAGTACCAGTAACTGAATGTAGAGTGCTGG CACAGTGGAATGCAGCCAGCTGCG GGGGATGTGGTACATGAGGAATGTGCTCATCTGCTCTTTTGG CCACGTGCTCCATCTTAGAGGTGCTTATTGTGTGGCTTTATCCAGTCTTTATGCCCCTCCTCTTTTTG CTCAAGTCTGCATTATAGCAGTTGTGACCTTTCCTTATCCCTGTTTTCTAATATGCTACTGTTACTGTT CCCTGTTCGTTACTGGT TTTTTTGTTTTTGTTTTTGCATTGTTCTATAGTTACTATTGTATATTGGAAATT AGAGATGCTTTCTGTACACTAGTACTCTTATTTTGATTAATTATGTTTGTTAACACTAATTACAAAG TTGCATAAGTATTAAGTAGTCTGCACCAAACTGTTTTGCGTAGGAGGTTTTTAAGTGCAAAATTTAAA AGATTGAGTATTTTCAGG GACACATTTATCACAAGAAATCTTATAAAAATGTCTTTCTCAGTAGAACAC rncrnn / Lznz / B / YiAi CTGTATCAATAAACCAAACTTTTTGAATGTTCATATCTAATTACAGTGTTTTTTGACTAATTTTATCTAT ATACCTGAAAAATTCAGTTTAACATATTAAACACTACAGGCCAGGCACAGTGGCTCACGCCTGTAATC CCAGCACTTTGGGAGGCTGAGGCGGGCGAATCACGACGTCAAGAGATCGAGACCAACCTGGCCAAC GTGGTGA AACCCCCTCTCTACTAAAAATACAAAAAAATTAGCCAGTTGTGGTGGCGTGCATCTGTAGT CCCAGCTACTTGGGAGGCTGAGGTAGGAGAATCGTTTGAACCCGGGAGGCAGAAGTTGCAGTGAGC CGAAATGGTGCCACTGCATTCCAACCTGGCAACAGAGTGAGACTCCATGTCAAAAACACAACAAA AAACACTCCTT GGAAAAAGTATAGGTACATTCTATATAGGATTAGTAGACTGTCAGAATCACTTGAAGA TGTTCCGAAAGCATGACATATCAACAAAGGACATGTGAGTCTAGAATGGTGATCCCTAGGACAGGCC ATATTACTGCATGCAAAGCAAGTCTTTGTTAACCTTATGACTTGCTCAGGAAGCAAAGTGTTTCATGTC CTAATAGGATAGTAG TATTTTCTGTTATGTTACATTTTAGGAAATTAGGAGTTTTGCATTGTCTTGTAAG AAGGTATTTTAAAAATTTTCAATGAAAATAATGAGAAATAGGTTTCCAGTGGTTTTATGCTTTTGGGGA AGAGGTTACTGATGTTTAGCAAAAGATGCTTATATATTCTTAATAGAACAAACCTGAGAATTAGTTCTT AAAGAGTTAAGGCCCATAAAAG AAACTGTAAGTGTTGGTACTCTTGTAGCTGGGCCACAGATCAGATC CTTAGTATGATAAAATTTGGTATTTTTGTGCTTCAATTTTTGGAGACCATTCAATGATCACTTACATTTT ATATTGTCTTTCATTGTGAAACATATATTATAGCAGAGGTGGGAGTCATTAAAAATTCTACATGTTGTA CACTACATGTATAAGGGTATATTT GGCGCAATGGAGGTAGGATTGTCTGTGTGCCTCTAAAATTAACC TCTCAAGTAGTTAATCTGATGATGACAAGTATGTCACTTTATTGATAAAAGGGAGAATTAAGACTATTC TCAGTATTATGTTGGTCAGTACACAAAATATCATTTGTTTTTACCTGTGAAATGAAATATCTTTCATC CTATTAGCCAGAAGGGAGAAAGCCTTG GCCTGAAAATAACACTTATCTCAAAAAAGTTGGGAAATGTGG TCCAACTCTGTGCCCAGGAAAAGAGGAAATAGATTTTGATGACTACATAGTCTCTGCACTGCTTGCCA GCTCATAAGTTTACTTCTTTGCACTGTTTGTTTTCATTGCTCAAAAACTATTTTCTGTCACTCTATGAGA TTTAGTCTAACCTGATTCCTGGCTGTGGAAAG CAGTTTCTACTTAAGAGCCGATGAGAAATGGTATAT TCTTCTCAATCACTCACAGAATGACTACCCTGGAACAAACTAGGAAGACCCAAAATGAACCAGTTTGA TTTTAATACATACATAGATGCTGAAGGAGCCTTTTTTTAAGACCTTGCCTTCTTAGTCTTTGGAGAACA GAGTACTGAAACAAAGAAAACTCACAGATTAGTAGTATTTCTGTGTG TTCTACAGTGAGGTTTTAAGAG CTGTATTATGATTAATCAGTACATGACATATTGGTTCATATTTATAATTAAAGCTATACATTAATAGATAT CTTGATTATAAAGAAAGTTTAAACTCATGATCTTATTAAGAGTTATACATTGTTGAAAGAATGTAAAAGC ATGGGTGAGGTCATTGGTATAGGTAGGTAGTTCATTGAAAAAAATAGGTA AGCATTAAATTTTGTTTGC TGAATCTAAGTATTAGATACTTTAAGAGTTGTATATCATAAATGATATTGAGCCTAGAATGTTTGGCTG TTTTACTTTTAGAACTTTTTGCAACAGAGTAAACATACATATTATGAAAATAAATGTTCTCTTTTTTCCTC TGATTTTCTAGATGTGACTTACTTAACAGAAGAGAAGGTATATGAAATTCTTGAATTATGTA GAGAAAG AGAGGATTTCCCCTTTAATCCGTGTTATTGGAAGAGTTTTTTCTAGTGCTGAGGCATTGGTACAGA GCTTCCGGAAAGTTAAACAACACACCAAGGAAGAACTGAAATCTCTTCAAGCAAAAGATGAAGACAAA GATGAAGATGAAAAGGAAAAAGCTGCATGTTCTGCTGCTGCTATGGAAGAAGACTCAGAAGCATCTT CCTCAAGG ATAGGTGATAGCTCACAGGGAGACAACAATTTGCAAAAATTAGGCCCTGATGATGTGTC TGTGGATATTGATGCCATTAGAAGGGTCTACACCAGATTGCTTCTCTAATGAAAAAATTGAAACTGCCT TTCTCAATGCACTTGTATATTTGTCACCTAACGTGGAATGTGACTTGACGTATCACAATGTATACTTCC GAGATC CTAATTATCTGAATTTGTTCATTATCGTAATGGAGAATAGAAATCTCCACAGTCCTGAATATC pncrnn / Lznz / B / YiAi TGGAAATGGCTTTGCCATTATTTTGCAAAGCGATGAGCAAGCTACCCCTTGCAGCCCAAGGAAAACT GATCAGACTGTGGTCTAAATACAATGCAGACCAGATTCGGAGAATGATGGAGACATTTCAGCAACTTA TTACTTATAAAGTCATAAGCAATGAATTTAACAGTCGAAATCTAGTGAATGATGATGATGCCATTGTTG CTGCTTC GAAGTGCTTGAAAATGGTTTACTATGCAAATGTAGTGGGAGGGGAAGTGGACACAAATCA CAATGAAGAAGATGATGAAGAGCCCATCCCTGAGTCCAGCGAGCTGACACTTCAGGAACTTTTGGGAGAAGAAAGAAAACAAGAAAGGTCCTCGAGTGGACCCCCTGGAAACTGAACTTGGTGTTAAACCC TGGATTGTCGAAA ACCACTTATCCCTTTTGAAGAGTTTATTAATGAACCACTGAATGAGGTTCTAGAAA TGGATAAAGATTATACTTTTTTCAAAGTAGAAACAGAGAACAAATTCTCTTTTTATGACATGTCCCTTTAT ATTGAATGCTGTCACAAAGAATTTGGGATTATATTATGACAATAGAATTCGCATGTACAGTGAACGAAG AATCACTGTTCTCTACAGCTTAGTTCAAGGA CAGCAGTTGAATCCATATTTGAGACTCAAAGTTAGAC GTGACCATATCATAGATGATGCACTTGTCCGGGTAAGTTGGGCTGCTAGATTAAAAACCTAATAATGG GGATATCATGATACAGTTCAGTGAATTCATTTTAAAAGTGACTGAAAAAAATGATACCATATAGCATAG GAACACATGGACATTTCTGATCTTATATAAGTATTATACTTTTGTTG TTCCTGTGCAAGTTTATAGATGT GTTCTACAAAGTATCGGTTGTATTATATAATGGTCATGCTATCTTTGAAAAAGAATGGGTTTTCTAAAT CTTGAAAACTAAATCCAAAGTTTCTTTCATTCAGAAGAGAATAGAGTGTTGGACAAAGACCAGAACAAGAGAAATGTGGAGATACCCAATAATAAGTGTGGATGTGCAGTCTTGAACTGGGA GTAATGGTACAGT AAAACCATACCATAAAATTATAGGTAGTGTCCAAAAAATTCCATCGTGTAAAATTCAGAGTTGCATTAT TGTGGACTTGATGAAGTGACCATGGCAGATCAGTGCCTGTTGCCAGTAAGAGTTGAGTCCTGCTGGG CCACTTAGAATATCCCTGTGTGGACGGCACTGCCTGGCTGTGGTAGTTTC TTCCCACTTAAAAATTCA TAGAGACAACTCTGGGTCTTGGAACTTCTGGAAAACAGCAGCTATTCCAAAAATCTGGGGATTAGTG GTGCCTGTAACATCAAGTCCAGGGAGATTGAGCAGGGAAATACTGGAAACTCAGGTACTCATCCTAA CTTCCTGGTTTTCCAGATGGGGTTGCCATTTGTTCCTTTTCTTTCCTCCACAAGATAATTT TAGTGTAT CTGTTTAAGAATATAAGAGTGGCCAGAGACAGAAAGCAGTCGTCAGTCACATTTCACCAAAATTTAC ATTTGTCTCAGGTGCATTATCGCAGAGCTTTATTGTATTTCTAGTATTAGCTATCCCTGTCATTGCTGC TACTTTTTTATCATCTTCAAGTAAAATTTAATGTCAACAAAAATTAAGGTAGTTAATAATACTATAG TATA CTAGTAAAGTTGTCTGACACAGACAACTAGGAAATGTGATTTTACTTTAAAATGTATTTTAGTTTTAGA ATGTCTAAATTTTAGTTTTAGAATTGTCTAAATTCGAGAATTCATAAAGCTGTAGCCCGGTGGAAAAAG TTATTTGATCTCGAAATTAAAAATTGCAGAGATTTTGTGTGTTTTTTTTTTTTTTGTTACTGGTTTG T TTTTTTTTTTTAATGTCAGATATGTTTATAGTGTTGGAGAAAGATTCTGCATTATTTAAGCAACTCAGGT GGTTTTCTAGCAGAGACAAAAGGGGGCTTTAACTGCCTGAAGTCATTATTATTGCTTGCTTTCTGGTA CCTTTTTATTTCACTTACATAGTTTTGAGACACATGAATAATTAATACACTTAATGACTGATCATAAGG CAGCCAGCA CCTTACTTTACATAGTTTAGCAGAATGATAGGGTATTTTATAAGAATGTGAGTGATGTTT TATGAAAGGTATGTTGAGGTCTGTCTATGACTATCCATTGTTGGAGCAGAACTGCAAATGCCAAAGCT ACATACTTTATGTTTGGCTTCTTGAGGTGAGATCCCTTCAGCTGTCTTCATCAAAAGCTATGTCTAGCC TTTAAAAGG CAATGAAATTACACTGTAAGAATCATTCCAGGGTTCAAAAAATTGTCTACCTTCCTTATC TGTCTTTCGCTCAGAAGTCTACTCAGTCTTATTTTCCTCAGTCCCCCATTTTTTCTCTAGTAAAGCAA GACTAAAAACAAAGTTTAAGTACTTGGTATATACTTTATTCTATATTTTAAATTCTATTCTAGAATTTTA AGGAAACAACTGCTTTTAAAGCCTT AGGTGTTAGTGTAAAATTAACTGTGAGCTCTTTAATTATGGTAA encenn / Lznz / B / YiAi CTTGTTTTTAGCAAGTTCTGCTTAATTATATCAAAATTAGATAATATAGTGTGGCCTATCATAAATCAGG ATTCACTAGATAGTATATGTACTTGAATATTGCCAGCCCACAAAAGCAGTTCACTTCAGAAATCATGTG TGTTAGGCAGTTTAATAAACTGTGAAAATAGAAAGAGATGATGCTTACAGAGAAGCTTCCTTAGGGGC TCTGAAT GCTCACACTAAGCAGATTTTACTCTTAACTTTCTTTTCTCCCTTGCTTTTTCTTCCTTTTCTTTT TTTTAAAAAAAATAACAGAATGTGAAAAGACTAGAAAACCAGCATCGAAATAGGTCTTATAAGTAAAAT TGATAACCTGTGTAATTTTTTGAAGTAAGTATTCACAGCAGGTGATGATTATGATAAAGCCACATATTT TAGTAACACATAGTAGAAGTTCTATA ATAGAAAGTGGTTTAAGATTATTCTTCTCATATGAAAGCTCAAA AGTGATGAATTTTCAAGATCTTATTTCCCAAGGATCTCTGCTTTTTTAAGCCTCATTCTTATATATCACA GTGAACAAACTAGTGGCCACTTTTTTATGACTTGCTAATTTTGGAATTGTATAGCAGGGTTGGGTGGA AAAGAAGAAATGAGAAACTTTGTGGTAAGCT TAATATTGATAAATAAAATTATGGGATCCTAGGCTTTA AGAGCTAAAAGAAACCTTAGAGTTATCCACTCCTTAGTTTAGAAATCAAGCCCAGAAAATAGTGACTT CATATATGAGACTCTTGTATGTTTTCTGTTGAGGAGTGGTAACTTGAATTAATAATTGTGGATTTTTTTA AAAAAGAAAAAATATATTCATTGCTTTTATATATTGTGAAATTCA AACCAGACTAGCAGCTTTTTTCCTGA GGTTTTTAGAGAAATTGTCTTTGATGACAAGAGAAGAATTCATGTTGATAGTATTTTCACTAATCTCTG ATTGTAGGAAACACTATCATTTTATTACTGCTAAGACAGAAAAATACCAGCAATTCATTGTAAGATGCT ATCATTTGTATGGTGTAATCTGATTTCAGAGATAATGTGAAAAAAGTGAATTTTAGA ATCAATAGAATAT AAGTTGTCTCTTCACAATACCTTAGAACTGCTTAAGAACACCCCCACCCTACCCGTTTAACTTACTGC CATAGTTCCCCTAGGACTTATTTTCAGTATTTTTTCGTTATTGTTCCTTAGAAAACAGTACAGTGATAAA CATGAGCTTAGACTTCACCTTTTCATTTGAATGACATTCCTAATGTGATGAGGTTTTTACAAATATGTAA A ACCATATTTACAAATTTACATTTTTAATATAAATATGTAATTTAATTTAATATGTAAATTAATTTAATTTA AATATGTAAATATTTACATATTTACAAATATGCAAATATTTACATATTTACAAATATGTAAATATTTACAT ATTTACAAATATGTAAATATTTACATATTTACAAATATGTAAATATACCCATTTGTGTGTTCTTTTACAAG TAGATAATTTCT CATTTTTCTTAGATGAAGCACTTCCAATGATAGTATGTATTAAGATTTTTAAATTACT TCTTAAAGGAGAAGATAGAGGTTATAAGTTTATGGAAGAATATAGTATTGCCATCATGAGGTCCCTCA AACTGCCTTCACATCTGAATGGGAAAATTGTTTAAAAAAAATAAATAAATAAATAAATAAAATCCAGGG CCCTAACCTCTAGAGGTTTAGATTAGA AGCTGTATTGTAGAGCCTATGAATCTGAACTTCTGGTAATA CTCCACAAATATTTTGATAAAGCCAGACTCCAATATTTGGGAAGATGGCCTTTGGTTCAGCTCAGGTG GGGGTGTGTGTGCATGTGTGTTTATGTGTGTATGTGTGCATATATAGAGAGAAAGAGAAAGGCCATTT TGATATACAAGTATG TTTATGTGTTTTGGAAACTCAGATTTTTAAGAGGATCATGGGGACAGCAAGCTT GGAATAGAGGATGATGATGATGTGAAACTTGGTTCCAATTAGTCAGGGAGTTCTAGCATTTCACATAA ATATCTAAAAACCAAAAGGAATGGCTGAGATGTGGAATTGAATAGGGAAGTTCAAAAATAGGAATTAG CACAGATAAAGGTGATTG GCACAGATAAAAAGCCCCACTACCAGGAGGTTCTGCAAAATCCCCTCTA AAAGTCACTGGCCCTTTTTATCTGGTTTCTAATAGCCTAGTCTAACCCAGCTTCCAGCATTTTCAGCTC CCAGCTTCCAGCATTGGTGAACACTCTTACTAGTGAAACATGAACGTAATTCTTTTATTTATTCATTGA CTCACAGAGCTTTAAAAATGAGATTATTCTGTG CTGCACTAGGTATGTTTAATTTTGTCTTACACATAC ACTATATTGTGGTTAACATGTAATTTCCATTGTTCTTTTCTTGTGATTTATTCTAATTGAAATCAAAAAATGA AACCAAGAAATATGCTTGGTTTATGCCCTCAAAGTAATTCTCAGAAACTGAATGAGAGAATGAAGCC TATATATACATAGATCCTCAGCATTATATAATAATTTAAGACAATGA AACATCAAACTTAGTATTACATG encenn / Lznz / B / YiAi 100 TGAGGAAAATGAAATCTAAAGAGATTCCAGCCTACATAAATTAATGGCAGAATTGGAAATAGAAGTC AGGATTCCAGGTCTCATGGACGAACGTGATTATGTGATTTGGTGTTACCCAAACATTTAAACTACATTT GAGATATAACAGACTTTTCTTCATGTGTTTATCGTGAACATGAAAAAATTAATTTGGATAATCTGGAAAT CTCAAGCA ATAGTTTAAGCCTCAAGTTGACTGAAGTAGTTGAAGCTAGCCTTTCTTTCTTTTTCCTCTT TTTTTTTTTTTTTTTTTAGACGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCAATCTTGGCTCACTGCAAGCCCCGCCTCCCAGGTTCATGCCATTTCCCTGCCTCAGCCTCCCGAGTAGCTGGG ACTACAGGCGCCTGC CACCATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTCACCGTG TTAGCCAGGATGGTCTCAATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAGAGTGCCGGGG ATTACAGGCATGAGCCACCACGCCCGGCCTTGAAGCTAGCCTTTTCTTAGAAATCCCAGGCATTCTTA AGTATTAGAGGTCTCTTTTATCT GATTATTGCTTCTACTTAAATATTCATGGTATTAAGGAATTTTTTAA AAAATTATGAATTGATTTGATGTAATAGCTCAGAAAACTATAAGATTTTAAGTGATAAGGTTTTCCTTTTGATTCCTGTAAGTCTAGTAATATCATATTTTGATATTAAGATGTCATCCTGCTAGGTATTCTGCAAATG CTTTGATATCAGGTCAGATTTTTTTTTTAAAAAAT GAACTCCCTAGGATTTCATCATCATGGCCAATTAA AAAGTTCAGAAATTAAAAATCATTTTATCCAGCAATTGATGAAATCAAGAGTCTTAAAGAAGAGGAAGT TACGCAGTGAAGAGGTAGATATGATTATATCCAGGATATTTTTGTTTATTTTTCCCCAGTAATCTCTGT CTGTTGCTAGTCTCCATGTTAAATAAATACAACATACACTGTACTTTTA AATATACCTAAAAATTGGCCT GGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCAGATCACAAGGTCA GGAGACCGAAACCATCCTGGCTAACACAGTGAAACCCCATCTCTACTAAAAAAATACAAAAAAAATAG CCAGGCGCGGTGGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAG GCAGGAGAATGGCATG AACCTGGGAGGCGGGGCTTGCAGTGCGCCAAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGA GCGAGACTCCGTCTCAAAAAAAAAAAAAAACAACAAAAAAAACCCTAAAAATCCACGTGTGTATTG TAAATAAATTCAGGCATGCATGCACGTTCTCCTTTTCAGAATGTTTAGACATAGTCCT CCAAATTTCAA ATATCCTAATGCATTTAAAAACAACTTCTGACTTAAAAAATACAGTTTTATGGTGAGGTTTGGGTTTAAAC AACAACATACAATTTTTAAATAATATAGCTATTATGTAAAGAATACACCTTTACAGTTTATTTGTTAAATCT TTTTTAAATTGACCGAACAATTGATGGAGGTTATTTTTAAGAAAAGAATTATCAGTACAGCTGTT TATG CAATAATGGCCTTTATCAAAATGGTTATTGCTAAATTTTATGTGTTAATAATTTAAAATAAAATAGTTTTA AAGGCTATTTATGTATTCTGTTTTCTACTTTTATTTATTTTAATTTTGAGACAGGGTCTTAACTCTGTC ACCCAGGCCTGGAGTACAGTGGCACGATCTCTACTGACTGCAGCCTTGACCTCCCACCTCAGCCTCC CAAGTAGCTGGGATGACAGGCGCATGCCACCACCCCCCACTATTTTTATTTATTTATTTATTTATTTA TTTATTTATTTATTAGTTTTTTGTAGAAACAAGGTTTCATCATGTTGCCCAGGCTGATCTCAAACTGCTG GGCTCAGGCAATCTGCCTGCATTGGCCTCCCAAAGTGGTGGGATTACAGGTGTGAGCCACGGCGCC CA GCCTTTATTCTTAAGTGGTACAGTATTTTATGAAATCACTTATGTGTACCAGAATGGTAATCTAAAAT AGGTAATAACAAATTTTTGCCTACAGAATTCAGTTACCAACTACTTTTCAAATTATTCTTTTTACATATT TATATTTGAACACATTCTGACTCTGAAAAATGTATTTGTTGTAAAAAATGGAAAAATATGGAAAAGAATA AGGAAAATAAAAA TCACTCATAATCCTAAAAAAAAAATTTTGGTCGTCATTGAAGAGAGTGAGTAAAG CATAGTAGTTAAGAGCTTGTTTCCTGGATTAGTATTCCTCTGTTCCACAACTTACTGTGACTTACTGTGAC TTGAAGTTATTCACCTTTCAGTATCTTGGGGTCCTTATCTGTAAAGTGGAGTTAATGTTTCCTTCCTC ATAAGGGTGTTG TGAAGATTAAATTAGTTGCTATGTGTGAAATGCTACAAAAAGTGCTATATATTATTGT encenn / Lznz / B / YiAi 101 TGCTGTATTCATGGAATATTTTTGTTCTATAATGCTATGGTAGGTTTTCAGAAAATATTTTAGAACCAAT AAAATAACAGCAACAACAGCTAGTACTTTTAAGCACTAACTTTATGCAGGGAATTAATCTAAGCAGTTC ATACATTAATTTATTACTATATTATTATGGTTATTTTACAGATGAAATAAGAGAGGTAAAGTTGTATGTTT GCATTTA CAATAGAACATATTGCATTGCATTACATTCTTTTGGCACCAAGGTGGGGAGCATAGAATAG AGATCAGTGGAAGTGGACAGACATGTAATATTTTATGGAGAATAAAGATAAATTTGCTTCAGTTATCAT TTGACATGTCTTAGGTAGAGCTAAGACTAGATAGAACACAGGGCCTCTCAATCCTGTAGAAATTCACC ACCACATCCTTTAAAAGGTT TTACATTGATAAGGAGTCAGCTTCTCATCTATGAATGTTAGTGGGGAAAA GCTGTAGAATGCACAGTCTAAATACCAGATAACCTTTTTTTTCCCCACTTTGGAATACATTATATTTGAT AAAAGCAAGTATACCTTTGGATGTAAAGGTAAATATAAACACTGACTTACATCTTTAACACCTAGCCAG TTGGGAACTGGCATAAGGAAACTCAGAATGGA TTACATGGCAATATGGAATGTTGGCCTGGTCCCAC ATTTGAGCTAAGATGTTAATTCTAATTTTAGTCTCCTCAGAATTCTGTATACTCCGTAGCTTGAAACAG GTTTCCAACTGAAACTATTTTTTTCCCCAAGGTTATTTCACATCTACATTTGTTTGACTCTAGATCTTG GAACTAGTCTATATCAAGTTCCTTTGGGGACACAAAA TTGCAAATCTGTTGTTCAGAGAGCAAAACTAT TTTAAAAGGTAACACTCGTTCTCATATATTCTTAATAAGCCTTCACAACTTACAGTATGTTGAGGAAAC TGAGGCTTAATTGAATCGCGTGCTAAAGTTTAAAGGTTAAAGTTATGGTAAGTGAGAGTTGGGACTA GTAAGGTGAATTCTGACTGACTCTTGGTCTTTCCATAACAAAACA TTGTCTAAAAGTAAACTGTGTGGC CTAAAAATGATTTTGTAAATATTAGAGATCGGTGTTGAACAACAACAGACATTATTTAAAGCTAAAGAC TAAATTCACAGAATAGGACCCTAAAGTTGAAGATACCCAGAAGATAATTTCAGCTAGTTTTGTCAAACT CTTTGACTGCAATCCCTAGTATTTTACATAGCATCCCAGTACATGCTTATCCATCTGTACA TCTAATTG AAACAAAAGTTTCACAAAAACAGTAGGTTCCATTACTATGTGGAATGCATTCTGATTTTCCCATTGCTGA TTGCAAACCACTAAATGGATTAGACTACCCACTAATGAGTTGCAGGTGACAAGTTTGAAAAAACAATG CTCTCGGGCAACCTGACCTGATGCGTTAATTTATGAGATTTTATTTTTTGTAGACAGACTAGATTGTC C AAATGAGTATTATTACTTTAACTACTATAGTGCTGTGTTACAGTTGTTTCAGTGATTATTGCATTTTCA AAACCATTTTTAAAATTCTGTTTGAAATAGTTGGAATAACCTGAAAACATTTAATATCCTGTTTTGGTAA ATTTTCATCTCCAAGATTAAATTTTTTTAACCAGCCAACAGATGTTTGAAGGCAAGTTAGGAGATATGA TGGAT ACTGGATACAGTATCCATCCATGTACTAGATACAGTATCCATCCATGTACTGGATACAGTCAT ACTGTTAGCAAATTTTAGATACATAAAGTAAAACAACAAAATGCAGTATAAACAGTTAATATTGGAAT CTAGTGTTGATTTTATGATTAATCTCAATGAGGTTACTGTATATTCATAATTCTATAGGTACACAAAAATATTTGGTAAAAGATTT ATAGTTGAGAAAATGCTAGACACTAAAGTTTGTTAACTTACAATTTAAGAATAA GGGCTGGGTGCAGTTGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCTGAGGTGGGCGGATCATG AGGTCAGGAGTTCAAGACCATCCTGGCAAACGTAGTGAAACCCCATCTCTACTAAAAATAAAAAATTT AGCCAGGCGTAGTGGCGCCT GCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTT GAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCGCGCCACTGCACTCCAGCCTAGGCGACAG AGTGAGATTTCATGTCAAAAAAAAAAAAAAAAAGTAAGGACATGAGTAAGGTTATGTCTCACCTGTT TTTAAGGAAATGTGGATATAAGATG GGTTCTAGTCCATTAAAGGTGGTAATTTATAACTAAGTCTTACT GTGAGAGACCATAAACTGCTTTAGTATTCAGTGTATTTTTCTTAATTGAAATATTTTACTTATGACTTAG TAGATACTAAGACTTAACCCTTGAGTTTCTATTCTAATAAAGGACTACTAATGAACAATTTTGAGGTTA GACCTCTACTCCATTGTTTTGCTGAAATGATTTAGCTGCT TTTCCATGTCCTGTGTAGTCCAGACTTA pncrnn / Lznz / B / YiAi 102 ACACACAAGTAATAAAATCTTAATTAATTGTATGTTAATTTCATAACAAATCAGTAAAGTTAGCTTTTA CTATGCTAGTGTCTGTTTTGTGTCTGTCTTTTTGATTATCTTTTAAGACTGAATCTTTGTCTTCACTGGCT TTTTATCAGTTTGCTTTCTGTTTCCATTTACATACAAAAAGTCAAAAATTTGTATTTGTTTCCTAATCCTA CTCCTTGTTTTTATTTTGTTTTTTTCCTGATACTAGCAATCATCTTCTTTTCATGTTTATCTTTTCAATCA CTAGCTAGAGATGATCGCTATGGAAAATCCTGCAGACTTGAAGAAGCAGTTGTATGTGGAATTTGAAGGAGAACAAGGAGTTGATGAGGGAGGTGTTTCCAAAGAATTTTTCAGCTGGTTGTGGAGGAAATCTT CAATCCAG ATATTGGTAAATACATTAGTAATGTGATTATGGTGTCGTATCATCTTTTGAGTTAGTTATTT GTTTATCTTACTTTGTAAATATTTTCAGCTATGAAGAGCAGCAAAAGAAGGATTTGGTATGGATTACCC AGAATCACACATCATGACTGAATTTGTAGGTTTTAGGAACTGATTTGTATCACTAATTTATTCAAATTCT TTTATTCTTAGAAGGAATATT CTAATGAAGGAAATTATCTCTTTGGTAAACTGAATTGAAAGCACTTTA GAATGGTATATTGGAACAGTTGGAGGGATTTCTTTGCTTTTTGTTGTCTAAAACCATCATCAAACTCAC GGTTTTCCTGACCTGTGAACTTCAAAGAACAATGGTTTGAAGAGTATTGAGAGACTGTCTCACAAGTA TGTCATGCTCAAAGTTCAGAAACACTAG CTGATATCACATTAATTAGGTTTATTTGCTATAAGATTTCTT GGGGCTTAATATAGGTAGTGTTTCCCCCAAACTTTTTGAACTCCAGAACTCTTTTTCTGCCCTAACAGA AGAGTTGTTATTGAACACAGTTTGGGAAAGGCTGATGGGATTTGGAAATTTGAAAGTGAAGGATCAGA ATTTTAGTTTTTTCCCTTTGTGATAAAGTAGA ACAGGGAAAAGATGCAGTCTTTTGGGTAGTCTACTT AACTTCATAATTCTGAACTGGTTCAGTTTCTACTGTAAATATAACCACTTAGTAACTGAGCTTGCTTAC GTTTAAAATTGAGTACATGACAATTACAGGAAAAGGTTTCCACTGAAGGTACCATCAGAATTGTGAGG AGTGTGCATAGAATAATGTATGTCATTTCCCTTCAGCTTT GAGATTTGAGCTGTTATAGCCTGTTGATT CTAATTGAGTTGACCTTTCTGTTACTGTTCTTAGTCACACACACACACACACACACACACACACACACACACA CACACACACACGCATCCCTTATCTATAATCTAGCTAGCTAGTGTTTTATTAATAACTAAAAAGCTATGCCATTT GTATGTAGTTTGTTCTAAGTAAATCAGAGATACATAAGACGACGCCCTTTTTGAGATAGAAA ATTATAA ACTTCATAAAGTTCTTAAATTTGGTAAACCTTAGCTCTAGCTTTTGATGTATCTAGAAATGTTAAACCTT AGCTATAAAGCATACTTGCATTATATGCAGAAATACTTGTAAGAAAAAACATAGATTAAGCAGTTCCAG TAAGATAACTGAAGTGATGGCAGTAGAAGTATCAAAAAGGAGTATTTTACCAGGAGGTTATGGTGC TT TTCTCCCTGGAACATGAGAAAATGTGCCTAAAATGGAACTTCAGAGTTATATTCTGATTAACTTATAGC TTGTTGCTCTTGGTTCCAAGGAAGGGCATTTGTGACATTTTATTAAATTCATTAATTTTTAGACACACC ATTGTCAGCTTGAACAAATTTATTAATTGTAATTATTTGTCAGCTGTTCTTGATCCTGTTAATACCATAC TT ATAACTAAAAAGCATTTCCATGGATGTTGTAACTTGGCCTGTAAAAAAAATGTTTAGATAGAAACCAT GAAACTCAAATATGAATTGTTTAATTTTTCAAACCATTTTGCATTCAGAAAATGTCCTAAGCTTAATTCAT ACTCCTAGTGATCAAGGAAACATGTTAAAGCTCCTTATTTTAAACTTAAAGTGACAATGACATTTTCA AAGATTTTTAAAATTCTTATA AACAGGTTAAAATACTTATATACTGTATAATTTGATTTCTGATTTCTAAGC TCTACTTTTCTATTGGAAATTACAGATTTTTTTCAGACTTAATTCTTAAGATGTTTTCATTGTTTCACAGT AGCAACTAAACATGTAGTAAAATGATTTAAATTCAATTAAATTTTTTCCTTAGTCATTTAAAAGGGAA GAAATCAATTTTAGTAGTACTCATTCCAAAGATTC CAATTTTCCTTTTTTTTAATCTTTTATTTTTTGGT GGAGGGAGGCAGGATCTGGCTCTGAGGCCCAGGCTGGAGTGTAGTGGTTCTGTCTCGGCTCACTGC AACCTCCACCTCCCAGGCTGAAGACTCAAACCATCCCCATGCATCACCCTTCCAAGTAGCTGAGACT ATAGGCACATGCTACCACACCCAGCTTATTTTTTGT GTTTTTGTAGAGATGGGGTTTCTCCATCTTGCC encenn / Lznz / B / YiAi 103 C TTGCACTAAGCTGAGTGCTGCTGCACTCCAGCTTGGGCGACAGAGCGAGACCGTCTCAAAAAAAAAAAAAAAAAAAAAAAGCCTCCATGATTGGGGCTTGCATAGTGAAGACCATGTGAAATTGAAAGACTACGA AACTACTTTTCTTTTACGTATTGGCCCATAATTAACATGTGTATTGAATAGCTTTGTTTATCTAAGTTCA TCAGATTTA TCCAGGTTTATGTATTTCCAGATCATCTGATTTTATTAGGAAAATGCTAGAAAAATTTCATG GCACCATTGTCTAATTTTGAAAAAACGAACCTTTCTTTACTGTGATTAAAAATTGTTTTTTAGGCCAGGT GTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCTGGCAGATCACGAGGTCAAGA GGTTGAGAC CATCCTGGCAAACATGGTGAAACCCCTTCTCTACTAAAAATACAAAAATTAGCTGGCGT GGTGGTGCACACCTGTAGTCCTAGCTACTCAGGAGGCTGAGGCAGGAGAATTGTTTGAACCTAGGA GGCAGAGGTTGCAGTGAGCTGAGATCGTGCCACTCCAGCCCACCCTGGGTAACAGAGCGAGACTCC ATCTCAAGGAAAAAA ATGAAAAATTGTTTTCAAAAATAGTACGTGTGGTACAGATATAAGTAATTATATT TTTATAAATGAAACACTTTGGAAATGTAGCCATTTTTTGTTTTTTTATGTTTATTTTTCAGCTATGGGTG GATAAAGCATGAATATAACTTTTCTTATGTGTTAGTAGAAAATTAGAAAGCTTGAATTTAATTAACGTAT TTTTCTACCCGATGCCACCAAA TTACTTACTACTTTATTCCTTTGGCTTCATAAAATTACATATCACCAT TCACCCCAATTTATAGCAGATATATGTGGACATTGTTTTCTCAAGTGCTAATATAATAGAAATCAATGTT GCATGCCTAATTACATATATTTTAAATGTTTTATATGCATAATTATTTTAAGTTTATATTTGTATTATTCAT CAGTCCTTAATAAAATACAAAAGTAATGTATTTTTAA AAATCATTTCTTATAGGTATGTTCACATACGAT GAATCTACAAAATTGTTTTGGTTTAATCCATCTTCTTTTGAAACTGAGGGTCAGTTTACTCTGATTGGC ATAGTACTGGGTCTGGCTATTTACAATAACTGTATACTGGATGTACATTTTCCCATGGTTGTCTACAGG AAGCTAATGGGGAAAAAAGGAACTTTTCGTGACTTG GGAGACTCTCACCCAGTAAGTTCTTTGTCATT TTTTTAATTCAGTCTCTTAGATTTTATTTAAATGCAAAAATTTAATTTATGTCAAAATTTTAAAGTTTTTGT TTAGAATCTTTGTTGATACTCTTATCAATAAGATAAAAATGTTTTAATCTGACCGAAGTACCAGAAACAC TTAAAAACTCAAAGGGGGACATTTTTATATATTGCTGTCAGCACGAAG CTTTTGTAAGATTGATTTCAT AGAGAAGTGTTTCTAAACATTTTGTTTGTGTTTTAGTGAAATCTTAAGAGATAGGTAAAAATCAGAGTA GCCCTGGCTAAGGGTCTTGGTAGTTACAACGAGTGTGCCTGCTCCTACCACCCCCACCCCCACCTTG AGACACCAGAATTTCTCATAGAGCACAGTGTGAATTCTATTGCTAAATT GGTGGTATGGGGTTTCT CAGCAGAGAATGGGACATCACAGTGACTGACAATCTTTCTTTTATAGGTTGGAAACTATTTGGGGGAC TGGAGGGATACTGTCTACACTTTTTACAATTTTTATTGATAAGATTTTTGTTGTCTTCTAAGAAGAGTGA TATAAATTATTGTTGTATTTTGTAGTTCTATGGTGGCCTCAATTTACCAT TTCTGGTTGCTAGGTTCTA TATCAGAGTTTAAAAAGATTTATTGGAGTATGAAGGGAATGTGGAAGATGACATGATGATCACTTTCCA GATATCACAGACAGATCTTTTTGGTAACCCAATGATGTATGATCTAAAGGAAAATGGTGATAAAATTCC AATTACAAATGAAAACAGGAAGGTAATAAATGTTTTTATGTCACATTTTGTCTC TTCATTAACACTTTCA AAGCATGTATGCTTATAATTTTTAAAGAAGTATCTAATATAGTCTGTACAAAAAAAAAACAAGTAACTAA GTTTATGTAAATGCTAGAGTCCACTTTTCTAAATCTTGGATATAAGTTGGTATGAAAGCACACAGTTGG GCACTAAAGCCCCTTTTAGAAAGAGGACATGAAGCAGGAGATAGTTAATAGCTAAGTGTG GTTGT AGTATAAAGCAAGAAGCAGGGTGTTTCTTGTATTAAGCTGTAAGCAGGAACCTCATGATTAAGGTCTT pncrnn / Lznz / B / YiAi 104 TATCACAGAACAAATAAAAATTACATTTAATTTACATGTATATCCTGTTTGTGATAAAAATACATTTCT GAAAAGTATACTTTACGTCAGATTTGGGTTTCTATTGACTAAAATGTGTTCATCGGGAATGGGAATAAC CCAGAACATAACAAGCAAAAAATTATGACAAATATATAGTATACCTTTAAGAAACATGTTTATATTGATA TAATtTT TTGATTAAATATTATACACACTAAGGGTACAAAGCACATTTTCCTTTTATGATTTGATACAGTA GTTTATGTGTCAGTCAGTACTTCCACATTTTTGCTGAACTGGATACAGTAGGCAGCTTACCAAATATTC TATGGTAGAAAACTTGGGACTTCCTGGTTTGCTTAAATCAAATATATTGTACTCTCTTAAAACGGTTGG CATTTATAAATAGATG GATACATGGTTTAAATGTGTCTGTTTACATACCTAGTTGAGAGAACCTAAAGA ATTTTCTGCGTCTCCAGCATTTATATTCAGTTCTGTTTAATACATTATCGAAATTGACATTTATAAGTAT GACAGTTTTGTGTATATGGCCTTTTCATAGCTTAATATTGGCTGTAACAGAGAATTGTGAAATTGTAAG AAGTAGTTTTCTTTGTAGG TGTAAAATTGAATTTTAAGAATATTCTTGACAGTTTTATGTATATGGCCT TTTCATAGCTTAATATTGGCTATAACAGAGAATTGTGAAATTGTTAAGAAGTAGGTGTAAAATTGAATTT TTAAGAATATTCTTGAATGTTTTTTTCTTGGAAAATTAAAAAGCTATGCAGCCCAATAACTTGTGTTTT GTTTGCATAGCATATTATAAGAAGTT CTTGTGATTAATGTTTTCTACAGGAATTTGTCAATCTTTATTCT GACTACATTCTCAATAAATCAGTAGAAAAACAGTTCAAGGCTTTTCGGAGAGGTTTTCATATGGTGAC CAATGAATCTCCCTTAAAGTACTTATTCAGACCAGAAGAAATTGAATTGCTTATATGTGGAAGCCGGG TAAGAAAGCAGGTGTCTGCAAAAAGTCATG TATCGATTTATTGTTTGTAATGATACAGTAGTATAGCAG ATAACTAAGACATATTTTCTTGAATTTGCAGAATCTAGATTTCCAAGCACTAGAAGAAACTACAGAATA TGACGGTGGCTATACCAGGGACTCTGTTCTGATTAGGTGAGGTACTTAGTTCTTCAGAGGAAGATTTGATTCACCAAAGGGGTGTGTGATTTTGCTTCAGACCTTT ATCTCTAGGTACTAATTCCCAAATAAGCAAA CTCACAAATTGTCATCTATATACTTAGATTTGTATTTGTAATATAATCACCATTTTCAGAGCTAATCTT GTGATTTATTTCATGAATGAAGTGTTGTTATATATAAGTCTCATGTAATCTCCTGCATTTGGCGTATGG ATTATCTAGTATTCCTCACTGGTTAGAGTATGCTTACTGCTGGTTAGAAG ATAATTAAATAAGGCTAC CATGTCTGCAATTTTCCTTTCTTTTGAACTCTGCATTTGTGAACTGTTACATGGCTTCCCAGGATCAA GCACTTTTTGAGTGAAATGGTAGTCTTTTATTTAATTCTTAAGATAATATGTCCAGATACATACTAGTAT TTCCATTTTACACCCTAAAAAACTAAGCCCTGAATTTCCAGAAAAGATGTAGAGGTTCCCAGTTCT AT CTGCTTTTAAGCAAATGCCCTTACTACTCTACTGTCTACTTCTGTGTACTACATCATCCAATTCTGAAA GACATAGGCTTCCCCATCCCCTGCTAAGACTGGTTCAAGTGGCAGCTACTGATGGATTGCAGTGAGA AGGCATGCAAACACGTACCTTCCTGGAAGTTGTCTCCAAAGGCTATTGCTCTAAGACTCAAGTATATA AACACT AGAATGAATATCAACTCTATCTAGCAATAAATGTTATTTTATATTACAGTTGACCCTTGAACA ACACAGCTGTGAACTTCATGGGCCCTCTGACATGCAGATTTTTTTTCTCAACTAAGAGCAGATTCAGT ATTGGTGGGACTCAGAACCTGCATATACAGAGGGCTGACTTTCATACATGCCAGTTTCACAGGGCCA ACTGCAGAACTTGAGCGT GCATGGATTTTGGTATACACACGTGGTCCTGGAACCAATCCCTGTCACA TATACCAAGGGATGGCTGTATGTTACTTTATATTCATTTGTTCTGTTATTTTATAAGGTTGTTCGTCGTG GTATGTGGGAATTCACCAGTATTTCTTCTTTCTGGTGCACCGTTGGTCATTTCTGGCAGCAGTGGTGA ATGTATTTACT CTTAGCAACCTCTGTGCTGCTACCTGTTCTGAGTTTCAAAGGTGATTCATTAAAGGGT TGGGATAACATGGTGATAGGAAAAACCCCCCTCATCAGTCACAAGGAGTATAACAGCAATATCTCTGT AATATGATTGATCATAGATATAATTCTAGTAGGAAAAAAAAGTCATATCTTGATGCATCTCTGAGAATA GTTGAACATATCTTGTGCTAT TCTTTATAGAGAAATTATCTTTGAAATTAAAGTCTTAATTTTACTTCTAG encenn / Lznz / B / YiAi 105 CTTTTTATAACAACATAATCCCTACTTGGTATGTATCTTAAGATCATTTTAAATGTATGATTTGAAGGG CAAACTAGTGTTATGTGAAAAATGACAGATAAAGTAGCTTCCAACTCATCCTCAAGAGTTGATGATATT CTAAACCTTTTCTAACTAAATTCAGCTTCTTAATTTTCTCAATATAAATATGATGAAAATATTAATTCATT AAATAGTCTACAAG TATTCGGTAGTTGAAGACTTAAAGTAGTGCTTGTAATAACAGAAGAGAAAAAAG ACATTACAGGCGTATCTCACTTTATTGCACTTTGCAGATACTGAGTTTTTTGGTGGCAACCCTGCATC AAGCAGGTCTACCAGCACCATTTTCCAACAAAATGTGCTCACTTCATTAGCATTTTTAGCAATGATTT TAAATTAAGATAATGTACTTATTTT TAGACAATGCTGTTACACACTTGACTACAGTATAATGTAAACGTA ACTTTTATAAGCACTGGGAAACAAAAAAAATTTGTGTGACTCACTTTACTGCCATAATCACTTTATTTGC CATGGTCTGAAACTGAACCGGCAGTATCTCTGGGGTATGCCTGTATAGATATTTTGGTTGGTATTTAT TTATTGTATGCAGAATTCATAAAAATAAAA ACTGCGAGGCTGTTTAATACATTTCAACTAAAAGTTGCC AGCATCATTAATATGTAAACCACTAGAAATAAGATTTTGTTAATTTTTTGTTTGTTTGTTTAAACAGTCTT GCTCTGTCACTGAGGCTGGAGTGCAGTGGCGCAGTCTCAGTTCACTGCAACCTCCGCTTCCTGGGTT CAAGTGATTTCCCTGCCTCAGCCTCCTGAGTAGCT GGGGTTACAGGTGCACACCACTACACCTGGCT AATGTTTGTATTTTTAGTAGAGATAAGGGTTTTGCCATGTTGGCCAGGCTGGTCTCAAACTCCTGACC TCTGGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATACCTAG CAAAATCAACTCTGAATCTGAATCAAACCTTTGAAACAAAATT ACCAATCAAAAAAAACGTGCAATCCC TGCTCCTAACTTTGAAAAAGTGACAAGGAAGGACATTTGGAAAGATGTCTCTAAGCAGTCAACAAGAA ATGAAATCAGGGAGAGCTTTTTCAGCACCTGAAAAAATACATGCAAAAAGCCCGAGGCGGGCAGAT CACCGGAAGCCAGGAGTTTGAGACCAGCCTGGCAAACATGGGGGAAACCCCG TCTCTACTAAAAATA CAAAAATTAGCTGGGTTTGGTGGCAGGCAGCTGTAATCCCAGCTCCTCGGGAGGCTGAGGCAGGAG AATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCTAGATCGTGCCACTGCACTCCAGCCTGG GCAACAGAGTGAGATTCCATCTCAAAAAACGAAAAAACAGATTCAGAGTTTATTTCCT TCCCAAATACT TCATAGATGTTGGTTTGTAGGAATAACTTAAAAGTCTCACTCGCTTTCTGTCTTTTCTAGTAATTTTAT CGTGGATTCTGATTGCCTAGATCTGCTAATTCATTGAGGGTTACAAAATTGTGATACTCGAATTCTTTA TTCCTCCTTCCTTTATTACCTGTAATACTTCTTAAGAAAAACTCTTTTCTCATCAACTCTATGACTACCCT AAATT ACAGATCCACATATAGGATCTGTATACATGTATATAAATATGTACATATCATATACGATAATGCT TAATTCTTTCCCATTACTTACTAATTTTCAAAATAATGTGATTCCCTAACTGCTCTCTGAATGTTATCAA TGTGGTGGTAATAATGGTGGTGTCGATGTTGTGTGGGGTAAAATTTGAATACAGTGAAATACCCAGG GCTTAA TTGGGTTAGTTTTTAAAAATTACATTTATGTAACCATATTTCAGTCAAGGTGTAGACTATGTCC ATCAGCACAGAGTTCCCATGTTTTCCCTTCCAGTGAATCTCCATCCCCCATTAGAACAGACAATAACT GTCCTAATTACTGTCACTGTAGCTTACTTTTGTCTGCTCTAGAATTTCTTATGAATGGAATCTTATGTAC TTGTACTGCATGAAG ACTCTTTAGATTCATCCATGTTATTGCATTGATTTATAGTGCCTTTTAAAAATT ATAGAGTAGTGTTGCATTATATGAATACGCAAAGTGTTTTTTTTTTACCTGTTGGTGGACAGTTGGATT GTTTCCAGTTTGGGACTATTGTGAATAAAGCTGTGTAGTCTTATTGTGGAAATGTTTTATTTCTCCTGG GCAAACATGTA GGAGTGGAGTTTCCAAAGCATATAGCAGGTGCATATTTAACTAAAAGTGTCTTTTCC TCATTTTTAATATTGGATTTTTGTATTTCTATTGACTATAGATATTTTCTTAAAATATAGCAGTATGTCTT ATCCTTAGTTTTGCTTTTTTTGGTTTCAGTTATCTTTGGTCAGCAGTGGTCCAAAAATATTTATTAAGT AGAAAATTCCATGA ATAATTCAGGGTTTTTGATGTATGTGTGTGTTGGCGGGTGCAGGGCAGGGAGA encenn / Lznz / B / YiAi 106 GTTGGTTGGTTGGTTCGTTGGTTTTTTTTTTTTTAAAGAGACAAAGTCTCTGTCATCCAGGCTGGAGTG CAGTAGCATGACTACAGATTGTTATAAACTGAAACTCCTGGGCTCATGCAATCTTCTTACCTCAGTCC TCTGAGTATCTGGGCTCATGCAATCTTCTTACGTCAGCCCTCTGAGTAGCTGGTACTACAGGT GTGCA GCTAATTTTAGTTGGTTATTTTTTGTAGAAACAGGGTCTCACTATGTTGCCCAGGCTGGTTTCAAAC CCCTGGACTCTAGCAATTCTTCCACTTCAGCCTTCCAAAGTGCTGGGATTACAGGCGTGAGCCACTG CACCCAGCCAACAACTCTTAAGTTTTAAATTACATGCTATTCTGAGTAACATGGTGAAATCTCCCACCT TTCC ACCCAGGGCATGAATTATCCCTTTTTCCAGTATATCGTTGTTGTCTAGACTACCCACCACTTTTA GTCTACTGGTTATCAGATCGACTGTTGCAGTATCACATGCTTGTGTTCAAGTAACCCTTATTTTACTTA ATAATGGCCCTAAAGCACAAGAGCAGTGATGTTGGAAATTCGAATATATATGCCAAAGAGAAGCTGGA AAGTGCTTCCTT TAAGGAAAGAATTTAAAAATCATATGTTGAGGTTGCTAAAATCTATGGTAAAAATGA GTATTGTATCTATGAAATTGTGAAGAAGGAAAAATAAATCATGCATAGTATATACAGGGTTCAGTACTA TTTGCAATTTCAGACATCACTGGAGGTCTTGGAACGTATTCCCCATGGGTAAGTGGGGAATACTGTAT ATTCTATATAAAAGG CCCATTTCTGATAAGTAGTTTATGATTTTCTCCAAGTTTTCATTTTCTTAAGT GTCTTCTGGTGAGCAGAAATTATTCATTTTTTGAGGTCTAATTTATTTTTTTCTTTTATGGTTTTTTATGTC CTTTTATATCTTTGCCTAGCCCAAAGCCACAAATATCTTATGTTTTCTTCTAATTGTGTAATATAGGTTT AACTTTTATGTGTAAATCT GTGATCCACCACCAATAAAATTTTGTGATGCTGTTAGACAGTGGATGTCA TTCATTTTTCTAAATAGTTTTATTTATTTGTTCCAGTACCATTTGTTAAAGAGACTTTTCTTTCCCCATTGA ATTGCCTTTGCACCTTTGTTGAAAATCAATCTGTGTGTGAGCCGTGTTTCTGGATTCTCCATTCTGTTC TATTAATTTGTTTTGTC CTTTTGCCAAAATGACACTGTTATGGTTACTGCAGCTTCAAATCAGATGCTG TGAGTCCCACAACTTTTTCATTAGGTTGCTTTGACTTTTATTTGCATATAAATATTAGAATCAGTTAATT TTTACAAACAAAAGGGCAAAGCCTGCAGAGATTTTGATTTGGGTTGCCTTGACTGGGGCAGGTCAATT TGGAGAGAATTCACATTTTA ACAATATATTCTTCCAATCCTTGAACACCGTACGTCTCTCCATTTATTTA GATGTTTGTTAGTTTATCTCAGCACTGTTTTATAGTTTTTAATGTTGAAATCATGTACTCTTTGGTTAGG AATAAACTTAAAATATGTTTCTAATGCTATTAGTGGTATTTTTTAAATACTGCTTTTCACTTGTTTATTAC TATCTTGAAATAAAATCGATTTTTATATATTGATCTT ATATCCTATAACCTTTTCTAAATTGACTTATTCTA GTAGTTATTTAGTAGATTTCATAGGGTTTTCTAGTAAACAGCTATGTCATCTACAAATCAAGACAGGTT TCTTTCTTTCCAATGTTTATGTTATTTATTACTGTTCCTCTATTGCACTGGCTAGAACCTTTGGTAGAAG GTATTCTTACTTTATTCCTCATTTTATTGAGAGAGACTATAATATTTACCATTAACTG TGATGTTACTTG TAAACAAAAAGTTTGTATTTCTCTGGGATTAAAAACCAAGAGTCCATTTGGTTTTTTACTGTTGAGTTTT AAGGGTTCCTTATGTATTTTCTAGGTATGTTCTTCCTTCATTGAATTGTTTTTTTCACATACGTTAAAAA TCACTTGAGAATATTTATATAGGTCTGCTTCTGAGATTTATCTGTTTATCAGGTTTTGTT TCATTTATTTT GAGGCTCTATCATTTGGTTCATACCCATTTAGAATTACTATGTCTTGGTGATTGGTCCTTTATCATTATA TAAGTTTTTTCTGTTTTGCGATTTTCTTTGCTCTGAATCTGATATGAGTGTAACCATTTGTTTTTTTTTAA ATTAATGTTTGCATGATCTGTCTTTTACTATCATTTTACTTTCATCCTGTGTTGCTGAAT TTGAAACGAA TCTCTTGTAAACAGCATATAGTTGTCATTTTAATAAAAACTGTTAGTCTCTGCCTTTTAATTTTTTTTATTT AGACCATTTATATTTAAGGTAATTATTGATATGTTAGGGAGAGGTCTGCCATTTTATTATTGTTTTCTG TTTCTGTCTTCTGTTTATGGTTATTTATTTATTGCCTTCCATGATTACTTGAACATTTTTTTAAGATT TTTA AGACCCTTGATTTATTTAGTGTTTGGGTTTTGTTTTGTTTGTTTGTTTGTTTTTGTTTCGAGACACAGTC encenn / Lznz / B / YiAi 107 TCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAACATCGGCTTCCCAGGTTCAAGCAATCCTCCCGCCTCAGCCTCCTGGGTAGCTGGGACTACAGGCACATGCCACCACACCTGGCTAATTTTGTATTTTTATTAGAGATGAGGTTTCACCATATTGGCCAGGCTGGTCTCGAACTCTTGA CCTT GTGATCTGTCCACCTCAGCCTCCCAAAGTGCTGGAATTACAGGCATGAGCCACCATGCCTGGC CTTCTATGTGTTTTTTATAGTTGTTTTCACGGTCATTGTGGGTATCACATTATAGATAATGTGACTTACC ACCATTCACTGCCATCAATACCATTACATGGAATGAGATATGGAAACCTTAATTTCAGTTGGGTCTCTT TCCCC ACTTTTAAATAGTATTGTTTTGAGGATTAATGCTATTACAGTTTTTGTATCAGTTATCCAATATG ACTTATAGAACTTATCAAGGGAGTGATGCTCTGTTGTATGTACCCATGTTTCTGCTATTTCCATTATTTT TTCCAAGATTCCATCTTTTATTACTTCCATTAGCCAGTCTTCAAAGGCAGTTCTGCTAGTGAGAAATTC TTTTTGTTTTTC TCTTTCTGAAGATGACTTTATTTTCCCTTTATTCCCAAAGAATAGTTTTATTTGTGCTA TTTGGGGTTCGCTCAGCTTCTTGAAGCTGTAAGTTTGTGTCTTTTGCCAAACATGGAAAATTTTTCAACC ATTATTCTTCAGGTGTTCTTTCAGCGTCACTCTTTTCTTCCATTCTAGGCCTCTAATGATACAAATGTTG AGTCATTTGTTACTGTTCC ACATGGACCTGAGGCATGGTTCATTTTTCAGTCTATTTTCTTCTCTTTTGTT CAGATTTCTCTCCTTTGTCATCTTCACTCTACTGTTGAGCCCATCTAATGATTATTTTCTCCTATTGTA TTTTTTAGGTCTATAATTTCCATTTGCTTTTTTTTCCTTGTATCTTGTTTCCTTGCTGAGATTTTCTATTG TTTCGTTTTGAAACAGTAGAACTTGTA ATTGCTTGTCAAATCATTTCTCTGATGGCAGCATTAAGATC CTTGCCAGATAATTTCAGCATCTTACTCATCCCAGTGTTGGCGTTTTCTTTTCCTTCATGTAATTTTCCT GGTTCTTGGTATGACAGATAATTTTGGATTGTGTCTCGGACATTTTAGTTATTATATCAGGAGACTCT GTACTTTTTAAAAATTTTAACTTCAGTAGTAACCTGTTA AGGTATAGCATGTAGGTACTAGCATATATTT GTGAGCTGTGGTTCCAGTGACCATTTTTCAGAGGCTTTATGGTGCTGTTTTGGTTTGTTGCTTTTATCT CAGTCCACTGGGGCTCGCACTGGTTCCTAGTAGTGCTGCTTGAGGGGCCTTCTCCAGGCTGAGCTG CGCAGAGTGTGTTTGGGTGAG GGAAGAGGACCCCCACTAGATTTTCGTGGGCTGGAGAGTGCTTCC TGAGCCTTGTGCCTGTTGTGGCAGGCTCCCCCTTGCTGGTGTTCCTGGCAGTGCTCCTGACCACATT GTGTCCCTGGGCTGTGGAACACTTGCAGGAAAGGTGAACACTGCCAGGACCAATTATAGCAGAATTC CTCCTGCCAGTACA CAGCAGCACTGTGGCTCTGGACCAGCAAGGAGAGTCTCAAGCATGGGTTTGTT TCTTTTTGATTTTAAGATTTTTCTTCTGCCTTCAGGTTCTGGTATTATTGTTCTGTTTTATTCACCTTTATGTTCTTCTAGTTTAGTTTTAGTTTCTTTGTATTTGATGGGATTTTTTTCCTTGCATTTCTAATTACTCCT TAGTTGTGTCAT GTCTTCCTTTTTTTCAGTTACCCTCATTCAGAAATTTCCCATTTCTAATGATTTGTTA TTTTTTAAATTCTTTTTAGCTCAGTTTGAAATTTGTTTACAGTTTTCATGTTTTATTTGCATATTGTTTCAT GTACTTTGATTTTCTGTAGGGACACCATTTCCATGTATATGCACATACTTTTTCTCTTAATAATTACACTG TTTCACTCTGTTCTGTTATTTAT TTATTTGTGTGTGTGTGTGTGTGTGTGTGTGAGTGAAATGAGTTTTCCA TACTTGGACGAGGGAGAGATGGGCCAGGATAACTTTTTTCGCTTTTTAGGGACGAGGAGAAGTCTGT GTTTTTGTAAAATGGTCAAAAATATGCCCTTGTGCTTTCTGAAACTGCCTTCTTTACTCCTCTATTCCCA CACATATATTTGAACT TTTTTTTGGTTTTTATTACTGACCTGGTCCATTCGGAAGTTATTCCAGAAGTT TTTTCTCGGTACAAGGTTTGTTTCTGGTGGGGGTTTGGTATTCGGGTGTTTTAAGGGCCCAGAGCTTA CTACATCATGATCCCTTTGTAATCATCTGCAAATTAGATCCTGTAGAACTTTTTAAAACTTTAAGCCCT GTTTTCAGATTGG CCTGTGCTTTCCAGTGGGTTGGCAGTGTTCTCAGGGCTGTCAGAAACCCAGTCA GTTACCTTGCATCTGCTTCCTTACTAACCAGTCTTGTAGTTGTCAGAGCTTTGTTTCTGTCCAATTATA encenn / Lznz / B / YiAi 108 TGCAATGGTTCATGGTTTTGTTGTAGATAATGTCTCTGGGTCTTTGGTTTTCTCATTCAGTTTGCTGTT TTTGTAGGGGAGGTTGGGAGGGAATAAAACAAAAATAATAATAATAATAACTATGTCGTTGCCATCA TCATCTTTCCAGAACCTGCTACCTGCCCTTCACCTGATTTTCGTATTTATCAGTATCATTACCTTAATCT GTTA TCTCATTGGGGATTGCAAAATGGCTGTTTGGGGAAAAAAAATTTCCATCTGCTTGTCCTACATAT ATACCTGGCATTCTTTTTTCTCATCATTGGGTGCCATTTGATTACCTTGAAAAACAGTTCTACAGAAAAA GGCATGATAAAATAGATTTAAGGTTTTTAGAGTAAGGAGTTAATGTAATAATTTTAATAGTGACAATTTA ATTTTG TTTTTTGGTTGGTTTTTGCTGCCTTTTTGAATATTACGAACTAATGAATGTTTTTGTATTTAATA CGTTTCACAGTCATTACTCTAAATGATATTCAAATTGCTTAGCTATCGTGTGCTTTTAAAATGACCCTAT TAGATTTTGAGATTTCTAACTAATCTCGAACATTCATTTCCAGGCCTGGAATAAGTTATTTTTCCAATAA ATTGTTGGAGAATGG CATTTAGAAGTCAGATTTTAGATGCAAAGTATGGCCTTTGCTTTTGAACGTTAC TGCTTGTAGGCCTTATCAGAGGACAGAACTAGGAAAATAATCTTCCTAGTGTATCCTGAGAATCATCC CACATTATTGCAGAGGTGTTTTCCATTTTGTTTTGTATGACTGAATACTGCTCCTTTGTGTGGATGCAG CATAGCTTATCAATATT TATGGGCATCGAGGTTATTTTAACCTTTTGCTGTTAGTACTAATGTCACAGT GAATCCTCTTAATGTTCATGCATTATTCCGTACATATGTAAAGTATCATTAAGATAAATTGTTAGAAGTG GGATTGTTGCATCAAATGGTAGATGCATGTGTAATTTTGCTAGATACTGCCAAATCCTCCTTCACAGA AAAATAACATTTTGCATT CCCACCAGCAGTTTACAACAGTATCCTTTTTCTTAAAACTTTCCAAACAGAA TGTGTTGTTAAATGTGGATGTTTACTTATTTGCCAATTGAGAAATGGTATTTTACTATAGTTACAATTTT TGAGCTTACTCCAATTATGAATGATAATGGACATTTTTCTTGTAGAGCTGTTTATAGTTTTATATAGTC TTTTGCTCATTTTGCTGCTCAGCTG GTCGTTTTCTTCACTTTTAGAAACTTTATATGTTAAGGAGATTAG TCCTTTAACGCTGGTAAATTCGCAAATATTTTTTCCCAGTTTGTCATTTGTCTTTTAACCTTGCTTATAG GATTTTTTGCCAAATGAAAGGTTTTATGTTTATGTAGTTAGCTATTAATCTTTTTCGTTATTATGCTTTG ATATGCATTTCTTTAGTTATGTTTATTTTAT TCATTTTCTTTGTTTTTTAATTTTCTAGAGTCTGTCCTCA GTAGAAATTTTAGTCATACTGCTTCTTCTTTGGTCACCTTATAATAAAATTAGCCTTTATTTCCAAAGTT ACCTTGCATATTTCTTCAGTATTTTTTAGTATTCTTATTTTTATTTAAGATGTGCTCATTTCTTTCTGAAT TTGTATTTCTCATCACTGGTGGTCTGTCTTGTCTGCT GCTGCATTCTCCTTTTGTGTTGGAATGTGGTG TTACTAGTTTCCCATTGTTTATGACTGAATTTTTCTGGTCTACTTTTGTCTACCGGAAAGTTTTGCTTCT CATTCGCCAGACTCTTCCCATAATAACTTTATTTAGACTTCCGAATTCTGTTTTTCTTGTTTATGTTTCT ATAACAGATGTTACTTTTTTCTGGACCTGTTATTACTAGACCTC ATGGTGGAGCAGGGAGGAATTGTG TGGCTTTAGGGGTCTTGGTTGAAGGGATCCCTCTTCTGTTGCTTTAGTAAGGGCAGAATCACCACTTT CTGATTTTTCAGCTCCATGTAGCTTAATGAAGACTCTTTTTCATTAGCTGCTTCCACCCCTTTACAGCC GCTTAAGGGACACTTCTGCTTTTGAAGGTACCCCCCTTCCTTTCATGC ATGGTGCCTTCCTGAGCCTG CCATTGCTGGACCCAAGTACTTTTCTGTAGTCCTTCCTTTAACCACCCTGTTGCCAGTGCTCTAACCT ACACTCAGTAGTGCTCTGTTGAGGGGCAGGTGGTGGAGGGGTGGGGTCTGGCCTTGGGTGATCC CTAATCAGTATGATTCCGCACAAGCCACTCTTCGAT GTAGCTCCTGCTGGACCCTGCTCATTTCCCCA CTTCTTTGGTATTTGGAGTTTATTGTTCTGTCTCCTAGTTTTACTCTAGACCTAAGTCATAGGTTTTTTT TTTATTTTCCCCTTTTTGATCCGGGTAGATTTTTAGAGATGTGAGTAGGATGTGATCGATACAGCCACC ACTTTTATGTGGAAACCTGGAAGCTTCTTCGTGTTTTCT TCAGCTTTCTAAATATATGCATTCTTGTTTA ATTCAAAATGTTAATGTAACACACATAACACTTATAGGAATAGAGATGCATTTTGTTCCCTGTTTTCATT encenn / Lznz / B / YiAi 109 GTATAAAATTTTAAAGGTTTCGTTTAAAAGTCCAAAGAAACAGCTCCGTAATAATATAGCCAGACTGG TCATTGTGACCACTGCTGATCTGCCACTTCCTGCAGGGTCTGTCTCTGTTCTTCGGTGGTGCTCTTTG GTTACCTCCTTAGGTGTAGCTGGTTCAGTTAAGCTTCAGAGCCCTCCTGCAGTGTGAGGAGGCTTT ATTACCACCCACTGCAGGGCAGCTTTTCTGCTATGTTGGAGGGTTCTGTGCTACAGCAGACTTGTTTT CTCTTGTCAGCCTCCCCAAAAGGAGTATCATGAACTGGGGTCCGATTCCTCTCCTCCTTACCTGAGA GATGCTCCTGCAAGTTTCATGTCCAGTTTTCTGTTGTTGTGTGTTTCTTTTTTGTTTTCTTCTTGCTGACT GGTGGATTTGTAAAGGGGCAGGGAAGGGAAGTGGCAAGAGATTGGAGAAAGCCAAGAATTCTAATA AAACTTTTAAGTTATTTCAGATAAATGGTGTTGCAGCACCAAAAATGCCAGCATTTTGGTAATAAAAAT AGTATGTTGGGATATTAGAATATCAAAAGGTAGAAAATTGTAATTACTGGTTTGGGATGTGT GATGTTC TCTGCTAACATTCTGGAATTTTTTTTTTTTTTTTTTTTGAGATGAAATTTTTTTTTTTTTTGAGATGGCTC AAAATGTTTCCCAGGCTAGAGTGCAATGGTGTGATCTCAGCTCATTGCAGCCTCCGCCTCCCATGTT CAAGCAATTCTTCTGCCTTGGCCTCCCAAGTAGCTGAGATTACAGGCATCTGCCACCACGCCCGG CT AATTTTGTATTTTAGTAGAGACAGGGTTTCACCACGTTGGTCAGGCTGATCTTGAACCCCTGACCTC AGGTGATCCACTGGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACCTGGCT CTGGAAAGAACTTTCTAAATAACTATTAAAATGCATTTTATATTATATAAGCAACTAAAAATACTTTTAAT TTTTTTTTTAATTTTT TAATCTTAACATTATTTAGCTATAGGCCAGGCGCGGTGGCTCATGCCTGCAAT CCCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACGAGGTCAGGAGATCGAGACCCATCCTGGCTA ACATGGTGAAATCCTGCCTCTACTTAAACGTACAGAAAATTAGCCAGGCGTGGTGGCAGGCACCTAT AGTCCCAGCCACTTG GGAGGCTGAGGCAGGACAATGGCGCGAACCCAGGAGGCGGAGCTTGCAAT GAGCCGAGATCGCGCCACTGCACTCCAGCCTGAGCGACAGAGCAAGACTCTGTCTCAAAAAAAAAAA AATTTATTAGCTATGAACTAGTGTATATATGTTTTATAGATGCCTGATTCAAATAAACTTCAAGAT TGCACTTTATGAGCTTGTATTTCGTTT TTTAGAACTCAAACTAACATAAGTGTCATTAAAACATAGCTTT TATTACATAGATTTTAGGAATGCCACAGGATAAATCATTCTCTTAAAATAACTGCAGGTGGCAGAAATG TCAGAATAATTTCTCTCCTCCATACACAGCACATATTACTTGTTTAAAGTATTCTAGTTCATATAAAAAT TGAACTTTTGTATTACTGCTATTAGGTATGTAGTTGTTTG CATTTGGGGCCAGTTGGTTGGGGCAGGG GGTCTTTTTTTCTTTTGTCCTTAATCTGTATCACTTTTTCCTCCCAAAGTTGAGTTAAAGGATGAGTAGA CCAGGAGAATAAAGGAGAAAGGATAAATAAAATATATACCCAAAGGCACCTGGAGTTAATTTTTCCAA ATATTCATTTCAGTCTTTTTCAATTCATAGGATTTTGTCTTTTGCTCATT ACTGACTGCATAATGTGATT ATACCATAGTTTAAATAGTCACTTCCTGTTACTACACACTTGGGTTTTCTCAATTTTTTACTATTGTAGT ACTAATATTTTACTATATTGTAATCTAATCTAAATTTTTACGTATTCAGAGCTGTTCAGGATAAATTTGCT TGGAAATTTTTAAATCACCAGAAGTGATACTATCCTGATAATTAACTTCCAAGTTGTCTCTTAATATA GT TTTAATGCAAATCATAAGCTTATGTTAGTACCAGTCATAATGAATGCCAAACTGAAACCAGTATTGTAT TTTTTCTCATTAGGGAGTTCTGGGAAATCGTTCATTCATTTACAGATGAACAGAAAAGACTCTTCTTGC AGTTTACAACGGGCACAGACAGAGCACCTGTGGGAGGACTAGGAAAATTAAAGATGATTATAGCCAA AAATGG CCCAGACACAGAAAGGTAGGTAATTATTAACTTGTGACTGTATACCTACCGAAAACCTTGCA TTCCTCGTCACATACATATGAACTGTCTTTATAGTTTCTGAGCACATTCGTGATTTTATATACAAATCCC CAAATCATATTAGACAATTGAGAAAATACTTTGCTGTCATTGTGTGAGGAAACTTTTAAGAAATTGCCC TAGTTAAAAATTATTATGG GGCTCACATTGGTTTGGAATCAAATTAGTGTGATTCATTTACTTTTTTTGAT encenn / ίζηζ / Β / γίΛΐ 110 TCCCAGCTTGTTAATTGAAAGCCATATAACATGATCATCTATTTAGAATGGTTACATTGAGGCTCGGAA GATTATCATTTGATTGTGCTAGAATCCTGTTATCAAATCATTTTCTTAGTCATATTGCCAGCAGTGTTTC TAATAAGCATTTAAGAGCACACACTTTGCAGTCTTGTAAAACAGGTTTGAGTATTTTCTCCACCTTAGA GGAAGTTACT TGACTTCTCAGTGACCTAACCTCTAAAGTGCATTTACTGATGTCCTCTCTGTGGTTTTG TTGTGGAAAGATTTAGTTAAATGAACTGTAAGAATTCAGTACCTAAAATGGTATCTGTTATGTAGTAAA AACTCAATGGATACAGTATCTTATCATCGTCACTAGCTTTGAGTAATTTATAGGATAAAGGCAACTTGG TAGTTACACACAAAA AGTTTATGATTTGCATTAATGTATAGTTTGCATTGCAGACCGTCTCAACTATAT ACAATCTAAAAATAGGAGCATTTAATTCTAAGTGTATTTCCCATGACTTACAGTTTTCCTGTTTTTTTCC CCTTTTCTCTATTTAGGTTACCTACTCTCATACTTGCTTTAATGTGCTTTACTTCCGGAATACTCAAG CAAAGAAAAACTTAAAGAGATTGTT GAAGGCCATCACGTATGCCAAAGGATTTGGCATGCTGTAAA ACAAAACAAAACAAAATAAAACAAAAAAAGGAAGGAAAAAAAAAGAAAAAATTTAAAAAATTTTAAAAA TATAACGAGGGATAAATTTTTGGTGGTGATAGTGTCCCAGTACAAAAAAGGCTGTAAGATAGTCAACCA CAGTAGTCACCTATGTCTGTGCTCCCCTTCTT TATTGGGGACATGTGGGCTGGAACAGCAGATTTCA GCTACATATATGAACAAATCCTTTATTATTATTATAATTATTTTTTTGCGTGAAAGTGTTACATATTCTTT CACTTGTATGTACAGAGAGGTTTTTCTGAATATTTATTTTAAGGGTTAAATCACTTTTGCTTGTGTTTAT TACTGCTTGAGGTTGAGCCTTTTGAGTATTTA AAAAATATATACCAACAGAACTACTCTCCCAAGGAAA ATATTGCCACCATTTGTAGACCACGTAACCTTCAAGTATGTGCTACTTTTTTGTCCCTGTATCTAACTC AAATCAGGAACTGTATTTTTTTTAATGATTTGCTTTGAAACTTGAAGTCTTGAAAACAGTGTGATGCAA TTACTGCTGTTCTAGCCCCCAAAGAGTTTTCTGTGCAAAAT CTTGAGAATCAATCAATAAAGAAAGATG GAAGGAAGGGAGAAATTGGAATGTTTTAACTGCAGCCCTCAGAACTTTAGTAACAGCACAACAAATTA AAAACAAAAACAACTCATGCCACAGTATGTCGTCTTCATGTGTCTTGCAATGAACTGTTTCAGTAGCC AATCCTCTTTCTTAGTATATGAAAGGACAGGGATTTTTGTTCTTGTTGTTCT CGTTGTTGTTTTAAGTTT ACTGGGGAAAGTGCATTTGGCCAAATGAAATGGTAGTCAAGCCTATTGCAACAAAGTTAGGAAGTTTG TTGTTTGTTTATTATAAACAAAAAAGCATGTGAAAGTGCACTTAAGATAGAGTTTTTATTAATTACTTACT TATTACCTAGATTTTAAATAGACAATCCAAAGTCTCCCCTTCGTGTTGCCATCA TCTTGTTGAATCAGC CATTTTATCGAGGCACGTGATCAGTGTTGCAACATAATGAAAAAGATGGCTACTGTGCCTTGTGTTAC TTAATCATACAGTAAGCTGACCTGGAAATGAATGAAACTATTACTCCTAAGAATTACATTGTATAGCCC CACAGATTAAATTTAATTAATTAATTCAAAACATGTTAAACGTTACTTTCATGTACTATGGAAA AGTACA AGTAGGTTTACATTACTGATTTCCAGAAGTAAGTAGTTTCCCCTTTCCTAGTCTTCTGTGTATGTGATG TTGTTAATTTCTTTTATTGCATTATAAAATAAAAGGATTATGTATTTTTAACTAAGGTGAGACATTGATAT ATCCTTTTGCTACAAGCTATAGCTAATGTGCTGAGCTTGTGCCTTGGTGATTGATTGATTGATT GACTG ATTGTTTTAACTGATTACTGTAGATCAACCTGATGATTTGTTTGTTTGAAATTGGCAGGAAAAATGCAG CTTTCAAATCATTGGGGGGAGAAAAAAGGATGTCTTTCAGGATTTTAATTAATTTTTTTCATAATTGAGACAGAACTGTTTGTTATGTACCATAATGCTAAATAAAACTGTGGCACTTTTCACCATAATTTAATTT AG TGGAAAAAGAAGACAATGCTTTCCATATTGTGATAAGGTAACATGGGGTTTTTCTGGGCCAGCCTTTA GAACACTGTTAGGGTACATACGCTACCTTGATGAAAGGGACCTTCGTGCAACTGTAGTCATCTTAAAG GCTTCTCATCCACTGTGCTTCTTAATGTGTAATTAAAGTGAGGAGAAATTAAATACTCTGAGGGCGTTT TATATAATAAATTCGTGAAGAAATGTGTGCTCTTCAGTTCTCAAGTTTTATTATTATGGTATTTATTAAA rncrnn / Lznz / B / YiAi 111 GTTCTACAATTGTAATAACGTATCCATATGACAAGTTTTAAAGTGGTAATTGAAATAGGTTATCAGATAT AGAGTTGTTCACATCAAGTAGACTTTTAACAGAGTCAGAATGAACCTACCCTTAAAATTTTAGAGAAAA AAAATCGTCGGTTGCACAGAATAGCTGCTCTAGCTTGCTTAATTATGCCGGGCATGTTGTCACTCCTC TTACT TTTGCTGCCTTTTCATTACTATTTAATGGAATGTCCCTGAACAATAAGGAAGAGCAAAACATAG ACATTTTGACTACAGTGGATACTTCCTCTACCCCAAATGTTATGTTATAAAAGTACTTTTTTTGCCCAG GTACTCTATTATATATTTTGGTTTTCTTTGAATTAGACCTCAATCTCCAGGAAGCTCTGGAGGGAAAAAAAGGAACCATAAACTAAAGTAACTG GTTTTCCAAATAAATGTAAACTTTTTTAACCTTTTATTATTATAG AACATTTCAAACATACATAAAACATGAAAACAGCCTGCAGCCAAACTTTTCTGGACCTTGGCAGCTCC AGCAAATGAGCTGGTCATCCTAACCCTGGTTTCCTGAGACAACTACTTTTGGGGATGCTTGCTTGTAT AGGGAGATGATAGATAGATAGATACATATCAA AAAGAAACTTGAAAAAGGCTTCGAACAGAACTTGCC GATGTTACTCATCCCTCCTCGGTACAGACATTCTGTTAGAACAGATGGTTGTAATGGGGCAGCATCAC TCCCTATTCCCATTAAAACATGACCATTCTGAGATTTCAGGCCCCTTCGAGGAATTTTCTCAAGAAT TCCATACAAACTGTCAGAGGAAGAAATGTCGTCCCAAGACTAGTCCCT GTGTAGTCTTGATCCCTTTA CCTGCTTACTGTAATTTTTTTCTCTGACTTTCCGCCAGTGTCTAAGGGCCATCTGTACCCCTCCCAC CCTTCCATGAGCCACTGTATAATCCAAAAACACACCTTCATTTGCTCCCTCACTTGTCTCCTTTTACC TCAACAGTGTTAGTGTGTAAAGAATTGCCTGGGGAGGGTAGAGGGTTTTA CAAGTACAGAGTCCCAA GTCTTTTCTCCCCTCCCCGTTAGTGGGTTGGCATTTATTAATAGGCACTGCAAGATTTTGATGCAGGT GTGGGGTAGATATCACTGTGAAAGGCTACTAATGCATGGTAGTTTCACCGAAAGTACAGTCTTCAAG GATCCTTATAATCTCCTCATTGCCAAAATCAGTAACATCTATAACCTTGACAACACCCTAG CTTGGGCT GTTGCTTCTCTGGCTACTTGTTTTTCCATCCCAGTTTACCCAGATTTTAGATGGATACTCCTCCAATTC TGCTTAAAGTCCTTACCTGTTCTTGCCCAGTTCCCTCTAGTCAACCTCAGTCACTCCCAAAGATTCTTC CCCAATCCCATATCTTTTGCTCAGACCTCTGTCTCTGGGATTCTCTTTGTTACCTCATAGTCAGTAGTCC TAAAAACAAATTCTTCATCTTGCATCTCTATCGACCGACCATTCTTTGTTTCTTTTTAAGAAATGTAAC CTTCACCCCAATCAATCAAAATCTCTCATTCTCTCAATTGTCACAGGTTGTCACTTCTTTCCCCCTAAACC TCTCCCATCATTCCTTCCTTCTTTATACTGCCCTTACAGGTCCTGATCCTCTGACTCACCCGGACATTC TTAGCAGCTGCCTAATTTCACT CCCTGACTCTCATTCTCCCCTCTTCCAATCCTTTTCATTGTGCTAGAAC ACTATCTTGCTAATTTTTAATATCCTCTGCATTCAGTGCCTCCACAGATTGCCCCCTCACTGACCTTTTCC AATTTGGCCTTTGTGTTACACACTTTCCTCGCTGCATTCCTACCCAGCATCTTCACTTGTCATATTTCTC AAATACTCTTCATGACCAGATATTTAAAGTACCTCATCC ATGAAGACTTCATCAACCCCCAAAGTGCCT CCAATGCTTCCGTGGTAGCACAGCATAATGGGGTACATTTCTTAGTTGAACAGTGAGGAGTCACTGG GATTCTTACAGAGTGTCTTAGGGTCTCCTCTTGATACTCTTTCCACATTTCAGTTAAGGAATTTTCTTA CATCTTTTTTTCTTCTAATAACCTTTGCCTGGAGTGTAAGTAAATTC ATGATAGAGACTGTCATTTTAA AAAAAAAACAAACCATTTTGCCTTTCACATGTTATTACTCTCATCTTTCTGTTATTCTTGTCAGTGTTGC CACCTAAATGATTGAAAATGACCGAGCATGCAGTAGAATGTAGTGAAGTTTCCTATTTCATCCATTTTTT TGCATAAGTGCATTGGTATCTGTATATCCATCTGCCCAAGCACCAGTTGTT GAAAAGACTATTATTTCC CCATGAATGGTCCTGGTACCCTTGTCAAAGAACAGTTGACCATAAATATAAGACTTTCTGGATTCTCA GTCTTACTCCATTGCCCTATATGTCTGTCGTTATACCAGCACCGCACTGTCTTGATGGCTGTAGCTTG GTAGTAAGTTTAGATTTGGGATGTGCAAGTCCTCCATTTTTTTTTTTTTTTCCCCAAAATCATT TTGTC rncrnn / Lznz / B / YiAi 112 TGTTTTGGGTCCCTTGCATTGCATATGAATTTTATATGATCATTGTGTCAATTCCTGCAAAACAGCTG GGATCTTGATAGGGATTTAGTTGAATTGGTAGATAAATTTGAGAAATAACTGCTATTTTAATGGTGTTA GGTTTTCTGTTCCATGACTGTGGGATGTCTTTGCATTTGCTTAGGTCTTTATTTCAGTGAT GTTTTAGA GATTTCAGTGTGCAAGTCTTGACGTCTTTAATTTTTTTCTAAGTATTTTACTGATGCCACTTTAATTATA TGATTATTTTCTAATTTTTTATTTTTTGTATTCATCACTGGTGTTAGAAATAAAATTAATTTTTGTATATTGAT TTTGTATATTGTAGCTTTTCTAAAATTCTTTTTTTGTCACTTAGTATTTTTTGCATATGAGATCATGCATC T GTGAACAGAAATACTTTACTTCTTCCTTTCCAGTCTAGATTCCTATTATTTCATTTTCTTGCCTTAGT GTGCTGGCTAGCACCTCCAGTACAATATTGGATAGAAGTGACAAGAGCAGACATCTTTTTCTTGTTCC TGATTTTAAGGGGAAAGCATTCAGTCTTTCACCATTGAGTATGATGTTAGCTAGCTGTGGGTTTGCTT CAAGTTGAGGA AATTCTTTATTAAACCTAGTTTACTGAGTGTTTTTAATCAAAAAAAAAAAAGGAG GGGCTGTGGGTTTTGTTAAATGCTTCTTCTGTATCAAGATTTTCATGTTGTTTTGTCCTTTATTAATATG TTGTATTAATGGACTTTTGTATATTGAATTAACTTTGCATTCCTGGGATAATCTCAGTTGTCCATGCTAC ATAAACCTTGTT CTATGCTGCTGGATTTGGTTTGCTAGTATTTTGTTTAGAATGTTTGCATCTATATTCA TAAGGAATATTGGTCTGTAGTTTTCATATTATATATCTGTCCAGTTTGGGGATGAGAGTCATACTCCTG ACAGAATGAATTGGGAGCTTTCCCTGTTCTTAAACCTACTGAGGTATTTTTTAAGTGAACTACTTGGAG ACCTTCACCTG TGATCTTCAGATGCTGGGGGACACAGGGATGGTACCTGACTCTGAAAAGGCTCTCA GGGTAAGACGTGTCTGAACTGGCCTGTGGCAGTTAACTAAAGAGTACTCCTACCAATAATGGAGTCA AGATGTATGTTTCCCATAGGCCACGCTGGTCACTGAAAGAGATGGGCTATGAGCCATCTTGAAAACT ACCCTGCACA AATGGACTGCCGGCCTGGAGCCAGGCACCCTGCAGCTGAGTGCCATATAATGTTGA AGCTGTTGAGGGAGGAGAGGTTGGAAGCTGCCAGCTTAGAGAATCTCAGCTGTGGTTTCCAGCAGG GTGTATTCCAGGAAAGAAAGTCATTCCCCACCCTGGCTCAAAGTAATAATTAACAGTGACTGGGTAAG GCAGGATCTTTTTT TCTAATTCCCTCCCCTCCAGAAAGGGCAGCAACAGCTCTTGAATGGGAAAGAAG GTGGAGGGAGGAAAAGAAAAACCAATTGCCCCAACACTGCTGTCTTTAAGCTTCCCACCCCAAAGACC TCAGTAAGAGGCAGAATTATGTTTTCAATTAAGAGAGAGTTTGGCCTCTTGGTGTTTCAAAAGTGTAG GCTTTTAATACCTAGAGAAACTG ATGATTTGTTGATTACCAAAAAAGGGACCAGAAAAGCTACATAGC CTGAGATTTCATCCCCAGAAAAACGAATCCAGAGAGCAGACTTGCAAAAAAAAAAAAAACCGTTCTG TCTCTGCCTCTCCCACTACACATACACAGTGAGAAAGAGAGTCTTCATGATTTGGTAAATTAGACCCA TGGAAAGACTCGGGACATTTAGGATGATGATATTTACGAT GAGGAAGATTTCTATGGGAAACTTTTTTT TAACTTGTCTCTAATCCTATTCCAACTGAAGTTTGAATTTTTTCCTTTCATTAACATTTACTGGGCAAA TACCTATTGAATGTTTGCCATTTTGCAGTGTGCCATAGGTTTCAGGCTGATTCAGAGCTGCTTTGTTG AATCAAGAAGTCTGTTACAGGGAGACAATCTAGTTAGACCAGGC ATAAGTACAAACCACTAAGGGTAA AAGAAGTATGTGAAAGTACAATGTGGGCAGAGAATTCAGATCCAAAAATACTGCAGATAGGTAGGTG ATGAAGGTCAAGCCGAATCTTGACATACAGGATAGGTGTATGTGAGTGAGTTAGGTGGAAAGTCTAG TATGTCTGAGTGTCAGGCTGTAAGGGATTAAGATGAGA TTGGGAAGGCAGGCAGGTCAGATAATGAG GGCCTTATAGACCATACCAAGGACTTTGGACTTTTATTTTGCAGACGTTAAGCAAAGACATAATCACTT TTCATTTTATATTTATTACAAACTGAAAGAGCACAAGTGCACATGTGGTCTTTGCAGTTAAGTTATTGC CATAATTCTAAAAAGGCAGATAATCTGAAGATAGAAGGGAGGCCACAG TCCAAGACATGCTAGGGAC TCTGATTGATTCAGTGCTCATGCATGGGAAAGATAAGAGTCAAAGACAACTCCCACATTTCAGGTTTT encenn / Lznz / B / YiAi 113 C ATAGCTGAACCTGTGGCTAGGAAAATTTCCCTGGAAAAGGCAGAGAGGAGAGAAGGACAAGGATG GAATGCATGGAAATGCTAGCATTTGAGAGTTATACACGGAACCCACAGTAGAGGCAAATGAGAAAA GCAGGTTTGTTTTTGTCTGCTCCAGTAGACAGACACCAAGCTCCATGAGGGCAGAGACTTTGTCTTAT TCGTGGCT GTACCTGCAGTGCATAGAGCAGACTGTACATGTGCTTTGTGGACCCATGCAGTTACTGG GGTGTCTCAGAAACTTCCCATCCTCCTCCCTACTGTGTCTTTGCATAACCCTGGCTGGGCCTCCCTTT TCTCAATGTCAACTCTCACTGTAACTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCAT TGCCCTG GCTGGAGTGCAGTGGCGGAATCTCAGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCC ATTCTCCTGCCTCAGCTTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCACGCCCGGCTAATTTT TTTGTATTTTTAGTAGAGACGGAGTTTCACCGTGTTAGCCAGAATGGTCTCAATCTCCTGACCTCATG ATCTGCCCACCTCG GCCTTCCAAAGTGCTGGGATTATAGGCGTGAGCCACCGCTCCCAGCCTCTTAC TGTAACTTTTAAGAAGGGCATATATCTACGTAGTGTCATCACCATAAAGATAAATCAACCAAGTGAAAA TATTTTGAAACTTTGGAAATGTATAAACTCCAAAATCATCATCAGTTACATCATCAATTATGTCCCTAAA GATCCCATCACTCTGCCTCACACTGGG GTCTTGCCTACTTCTCTGTTCCAAAAGGGCACAGTAGTGG TATCAAATCTGTTTCTTGAGGCAAATGAAGTACCTTGCTCCAAAATAATCACCCACAGCAGGCAGATA ACCTCCAAGTGCTTCAAGCTGAGATTGAGCAGGAGGATCCCAGCTCATCACAACTGGGTGGTAAATA TACACTTGGGCCCAAATGGAAGGAAATG CATTACCCTACAATGCATACCCAACATGCTTGCATCCAG GCCCCAAATCCAGCAAAACAATGCTATTCCCCTTCAACATGTGTTAACGGAACTGAGATATTTTTCCA ATTTAAATTGTGTTCCCCAAAGTCTTCATTATTCTCTAGTGCCTATTACAATCTGTGTTTTTATGTTTAC TTCATGACTGCCTAGTTCCCTCCTGAAATTTTAAGCCTC GTGAGAGTAAGAACTATCTGTTTTCTTTAC TCCACTGTCCTGTACATACATACTTGTTGAATGAATGTATGAATGCCACCGTGATTGCAAAGTCCAAG GGAAATGATGTTGATTCACTGCACACTGTACAGGAGGGTGTCAACCAGACTTCCAGATTTCTACAGAA ATTACCAGTAAAGGGTAGTATAAGAATGGTTCCTGCATGT GAAAAATGATCTTGGATGGAGCTGTTGT GGCATTCACCTGCTCCTCATACTCTCCTGCCACTGTGCAGGGACAGCACAACCCCCGTGCTGCTTTC TTGAGTGTAGCTCATTTCAGAAAAGCAGTAAAAGGAAAACCCACTTGTTTGCTTTATGTTCCTAAGAAG GTGGTGAGTAAATCAATCACGTTATCCTAAGAAGTGACT TGAATTTTATGAAGGCTCCTTTGTTTCCAT TGCACTCCTTTCTACCCATCTCTACTCCCACCTCCACCCCCACCCTCAAATCATGCTTATAATTTCCAT TATTCAATTAAGGGTGGCTTTTTTCTCATCACAAACATCTGTGTGCTTTAAATAGCTTCTACATAACCG AAGTGGAAGTAGTCATGTAGAACAGCACATGGCCACTCCAGGGGAC ATGAGAAGCCTCTGCCTAAAG GTAGTTCTCCCCTTCTGTCATCTGATCTCACACATGGCACTGCAAACCTGCAGTTATTTAGCCATGTGC TTTGTGACATTGATTTCACTTCCTTGGGTTATTCTTACCGTCTTTAGGAACTTAAATATTTAAGAAATAA ACAAATACTATTCAAAGAGAGCTGTACCATTATTATATGCATTTAAGTGAAAAACTACCACTTC CCATA TATATTTATCTCATGACCACCTAATTGATAAAAACATGTTAACTGTTATCTTATATTGCCTCAGGGAAAA AGTCTGAATGTTGATTGGAGGCACTGCAGGATAGCCATTCGATACCTGCTTTTGTGACAATAAACTAA AGCATTGGATTTTGGTGGATTAGGGATAAAAATGGCTTGACAGATCATCTTGTCCAGCCCTCAGTATA TAG ATG AG AAG ACTTAG GTCTC AAG CTCTG AAG CG CTTTG CTC AG G ATCG CTGG CCATTTC ATATATG encenn / Lznz / B / YiAi 114 TAACAAGCTCCCACTTCATGCTCATTTCACAGTAGCGTGTCACTTTCAGGTCAGCTTCCTTCAGTGGG CGTTGTCTTTGCTTAATTAAATGTCAGGAGGTCCCCCCAGAAGGCTTGACTCAGGGAAGGAGGGCAG ACCCTCCCAGTTCTTCCACTGACTAGCTTTCGTTTGTTGGATTGTTTTTACTGATAAAAAAGTTCAGAA ATTAGAG CCAGGTTCCTGTTCACGTTCCCTACCCAAGCCCCTGAAGAAGCAAATTGGTGAATGTTCC CCAAATTCTTTTTACTCTCTAGTATACAGTAAGCAGTACTGCCAAAAAGTTTCCCAAAGTCATGTTCCTC TTAGATATTTTTCCTTGAAAACTGTTGTCTGGCATGGAGATCCAACCTGTGTGGAAAGTTCCAGATGC CCTGGTCCTAGCTTCAC CTGCCCTGCTTTTGCTTCCTGTTCTCACTGCTTGTCTCCAGGTTTCCATTT GAAGGCTTGCAGTGCTACTGTGCCCTTACTGTTAAATCCTGCCTTGCTTGCCATGTTTTATAGACAAG GAAAGCATTTTCTACCAGAGCTCAGGAGCAGCCTTGAGGTCAGGGGTAACGTTTTTCATTGGTAAGT ATTCAGTAGTTGCT GAATGACAATTGGGTGGAAAGGGGAGGGGTGCCTTAGAAAAAATGTCTGTTCT TTGTGGTAATGAAATTGCTTCCAATTTATTTTCTGATCTCTTTGAGAACTATTTCCTGTCGTCTTCCCGC ACCATGCATTCTGATTTCGGGGCATTCAGTGCTCCCTCCCTTCCTTTATTCAAGGGGCTCTTGGAAA AGAAAT CTCTGAAGAAAAAATGTGTGGGCAGTGGGAGACTTCTCATTCTTCCACCAAATACTTAGCC CTTTCATTCATGAGAAACCCCTGCTTTAGGATGGTGTGGATCTGAGTCAGCAGGGCTGGGTTCATTT GTATATACTCCAGGTTGTGGAGGTTGTTCCTGGGTCTTGGCCTTTCATTTTGGGAGTGCTCCACACTT CTGTCTCCATATACTATGTATTTAAGAAGCTTGCCTTTCGATTTCCTGCCAGTGGCTGGATCTTGGGG ATCACTGCACAATGCTTGTATGCCCCACTGGAGAAGTCTCTCATGGCACCTTTCCCCTCCATGGTG GTGGAATGCTGTCCACAGAAAGCTTCTCTTCACTGTTCAGAGACTCTAAAAATAAGACCTGAACTGAC TTGCTCT GCCTACTGAAAGGGGACCTCCTTATATTCACCATTGCCCTCACACCCTTTTCCTTGGAGTC TGTCTTTAGGGTCACCCTGGGAGCTGCCTGGGCCTCCACCTTTCTTAAGGAGGCAACTCCTGAGAGCT GGGTAGGGACTGTCTTTGTCCAGACTGTCTGAAGAGCATCTTGTTCTTTACCTCCCTCTCCTGTTCTT G ACTATTG CCTTC ACTG CTGCCTCG CTCTCGTCTACC AGGGTGGTATTATAAAGTATGTCCTTG G AGG TGAGCTGTTTGACCAGCTCCTTGTTGCCTAGAAACCTAAGAAATTGTCAGAACAATCCGGCATGCATC AGCTCTGACCTTTGGAGCTTTGACTGGCATTATTTATAAAAGGCTTTCTGCTCTGTTAGCCGAGCATT GG CTTCATATTTCTCCATGGACTCCAGAAAACTGGGTTTCTTTTTTGCAAGTTCTCTTGTTTTCAGTTG AGAACGGTATTGAGTAGGACTTCTCTGTTTCCTTGAGTTTTATGTTCTCTCCAAATATGGAATAGCACT TGCTTCCCTGGGTGCCAACGCTGGCCGACCAGCTCTGAAAGTTGCTCTGCTTGTGGTTCTTCCCTGA GAT GCTAGTTGGGCCTGGGAATCTTCCATTTCTCTGCCCACCAGGTGACCTGGCAGTCAGTGTTCTG TCAAAGACCTGTGAGGGTGCTTAGTGAACTGTGGGCACTATGACCACAGGGTACTATTCTGGGTCCC AGTGTTTGTTTTTAAGAACTCTGTAGGTTGACAGGACATGCTGTCTGGTGGCCAAG TGCTTCTGCCAA GAGTATGGGGCCTGGGAGACATGTTTCCTGGCCTGCTTATTGCAGGCCTAGCTTCCACCTAAGAGCT ATCCGCTTCCCAAGGGGACATCCACCATGTCTCTGTGATAGGAGCTGAATAGTAGGGGCAGGACTGA AAGGTCTGTATGTTTGCTTTTCAGTCAGGTACAGGTGTTGGAGGTT TCTTAAATTTGGTTTCTTTTGAT CTCCCTGGCAGGCAGTGATGGGGAAGTTTTTAGTAAGGTTATTAACAGAGATAGAGGATTTAGAGTTA AAATTTAATAGGGAAATTTTCTATAGGATGGTTGAAAATGATGCTTTGTATAGTTTTATTGTATGAACT TTTCAGGGATAGAATTAGTCAATTTGTAGAAATTGGGCCGCCT CTGTTATTGTGATATATTAGAACTGT ATTGAATGATGAGACTTCCCAAAAGTTTAAAACAAAAAAAGGAGGCAGAAGAGAACGAGGATATAAAT GAGGACACTCTCGCTGAGGACACATCAGCTGTTAGCAGTCTGTCTCTGTGTACCGAGCTCAAGAACT encenn / Lznz / B / YiAi 115 GTGACTTTGGTTGGAAGTTAGACCTTTTCTATCCAGCTTCAGACATGGTAACCTTCACATAAGCTGCT GGATTTGTTCTACCAGAAATTTAGTCTGTTGTGTGACTCCAGCCACTTTGCAACTCAAGATTATTACTT GTTC AG GTTTCTTTC ATTAAAT AG CTAACC ATTTAAC AACTATTATCTTTCTTAG GGTCG ACTG ATG GTTA CCCATACAGTATATACATCATCCATATCCTTTCCTCTCCTACTATATCTCACTCCTATTTTCCAGTCCAT CCTCATCTCTCCTCAAGATCAACAGACCCCAACCTCTTTTACTTAAACGTTGTATTCCTGAAGTAGTCC TGCCCTTTCCTTCA GCCTGCGAAGCCTTCTCAAAGACTTCTTTTCCATGCATCTAGACTCTGCCTGGT TATTTCCCTTCCTTCAGAGTTATTTCTTTGTCAAATGCTGCTAATGTATAAAAACACAAAGCTTTGATAG TTCCTTCTGTCCCAACGGAGCCTTACGCTTGGCTGACATTTAGGGTAAAGGTGGTATTTTTATTAGTA AAATTAATGATACAGAAG TGAATTCTAAAAATAGTTACATAAATCTAAGAGAGTTTTCATGAATTCAG GTTGCCCCAAAGATTTAGGCCATACCTCTTCCATGGAATGGCTGTCATGCAGTTTGGATGGTTGACCT CAAAATTATTCCCAGCCCCAGAAGTGGAGTAGGTATATTAGTCTAAGGCAGTCAGGGTAATGCTATCT TCCATGCCACAGATTGGCTTGGAAT GGGGATAACCAAAAGCACTTTGGGCCTGTGAGATTTGACAGA GTGTTTACTGTGAGCCTAGGGAAAGAACATGCCTGCTTCCATGTGAGAGTATGAAGAAACACTGCCT AAGCAAGGAATCATGTGGCTCCAGTTTTACTGTCAGCCTTTCTACCACCAGGGAGACCAGCCTTGA GATGATGCAGGTGCATGGACAGCTG TGTGGAGGGATAGAAGAATCCAGTTTTTAAACCAGATGGCTG AGCTATTTCATTAAGTCACCCCAGAAGTCTTCAACTAACAGTATCTTAACTGGTGAACTCCTGTGACTG ATACAGGAAAATTTTACTTCGTAACAAAGTATGATAATTCCTTTGTGCAGGAAGGAGGTTTTGTGGAAA TGATGTTGATTCACTGCACACTGTACAG GAGGGTGTCTCTTTGACACCACCAACCTTAAATAGTAGGA AAGCCATCACAGTGGGTTGGGTGGTTGGATTGCTTTATTGCAACTAATAAAGGGTCAGTTGTGCAGTT GTTAACTATCTTTCACTTCCCTCAGAACTGTATCTCCTAGCCCAGTGCCCTATAGGTCAAAAATGCCA GTTTGTTGTACAGTCAGCAGAGCCCAGT ACTATGCTTTAAAACATTCGGGGATAATCATCAAATATTTA ATCAGAACAGATGCTGCCTGTAAACAACCACTGCAGCCAAGAACAGTCTGCATCTGAAACACTGCCT GCAACTATAAATATGCCCATATGCTTGAACAATTTTAGTGTTGTAAAAATCTTGTTTTTATAAGCAATTA GTTTCATCTCCTATTATATGAGGATTAACTTTGCAGTGAT GTACTGTTAAAAGAGAAAAGATCAA AAAAGCCTTGGTTGTGGTGAAACCCAGCAAAATGTGGGTCTGCACCAAGTTCCAGATGAATATCAAA CAGCACTGTCCCAGTTGGATTAAGGTGATGACACCCCTACCATGGCTACAGTACCAGGTCATTTGATT TTCCCCAGGGTCATAGGAGTGTTAGCCCAGGTGATCAGCTCA ACACCCCCTGAGATCCATGAGGTAT ATACTTTGAAATTTCAATTCCATTACTACTGACTGCATTCAATCCTATGTTAATACTTTCTTGAGTAAT ATTCTGTTGACCTAGTTATCCACGTTGGAAACTTCAAAGGCATCATCTTCAGCTCTTTGTTTCTGACTC CCTATCCAGTTCTCCAGTTCTGTATACACCATCCCAGAAATGGTCCTCGCATCCAGT TAATCTCTGAC ATGGACTAATAGGCCTTTCTACAGCTTCAGTGTATTCTCTTTCTCTGCTTCTGGAACCCAGGATTTAGG TGCTACAGTCATACTATCTTTGACATTCCATCTCCCTGGAGAATTTGGAAATGGGGAAATAACATTACT CTTAACAAAGCAAGATTAACAGTCCTGTAACCAGACCCAAGGCACTGACCCTTCTGTGAAAGCCTATA TCCAACCAGCTACAGGAACCTCTACAGAGAGACTAAAAAAGGCCAGCCCTGGAGGAGCCAGTGGTC AGGAGAACATAGGCATAAAGCCTCCTAAGGATGTAGCCCATCAACCCTGGGAGTGGGTTCCTATAAG GAATAGGCACTTCGGGCAAATATGGCCCGATGACACCAGCCACTGGGATCTTCTGACTCTTCTCCTGT ATAATGT GAGTTCATTTGTTTATTGTGTTTAAAGTGAATTCTGCCTCCCTAAAGGCTGAGAACTTCCTT TGGCTCAGTGTTCACTTCGTTTGGCCTCTGACTTCCAACTGATGCATCAAGCCAATGCGCAAGAAAAG encenn / Lznz / B / YiAi 116 TTAATAAATAAAAATAAGATTTATTACAGAGCCAGCTGGGCACTCATACATACATGGAGGAGTCCCTG TGTCATTGGAACACTGTAGCTTTTCTCTACAACAGTCCCAGGCTAGGCAGCTCTTTGTAGGCCCAAG GGAATTGATGCATAAGTAAGGCATGGTCTTCCTTGACTACACATCTTGTATACAAGGTATTAAGGCCC TTG GCCACCTGACTTCGGCCCATTTTTTCAATCTCAACTCTACCCTAAATTCCCCACACAGGTCATTCA TTCTCCAATGAGGTTATTCTCCTGATCTCTGTGTGGGTTCTTATACATAATGGAATTGTGTGTTTTTCT CCTGTTTAAAGTTTGGAACATCATGTTAGCCATCATTTTATTCTCTTTGCTTTCACTGTATTGCACTCAC ATACT GTATGTGGAATCAGTGCTACCCATTAGACCCATGGCTCATCAGTGGGAAATGGTGTCAGATCT CACAGAGGGCAGCTTCATGGGGCTCTAGGTTCTTCAGGCTTCCTTCACAGCCTAAGCTCCATATTTAA ATCCAGCATTCAACCCTAATCACTGCTGTTCACTAGCATCTGCTACATATTCTTGCTGACAGACACTGT GTTTGC TCTTGAAAGATAACAAAATGCTTGAAGCTTCCCTCCAACGAGTGATAATTCACTGAAGCTCA GAGGCAGCAGGAGCTCCAGTCTGCTCTGCTGCTCTGAAATTGTGGAAAGTAGGAAAGGTGTCCAGA GGTCATATGGCCCAAGTGATGACATATCTGAAGCACAGAGAGGGGATGGGCTAAGAGTCACCTGTAT CCAAAATTCAAG TTAACACCTATCAAGTTGTGAAAAGTTACTTTGGGACATCCCAAAGTTACACAGAG AGCTAGAGCTAGGACTCAGACCTGGAACACCAGACTTCAGTCTCTCTGAACTGCACTGGGTTGTCTC TGCTCAAGCCTTATTGGAGAGAGAACTGACAAAAGGCAAGGCTAAGGAGTGCTCTTTGTGGATGCAG CAGGAGAAGAAACACCCCTTCCAATGA GGGGTCCACACAGAGTTCAAATGTCCCCTTTGTTCATACTG AACGTGGGTATGGTTTTCCTCTTTTGCTGTCTGCACAGGTGGCATAGAAGGCAGCACCTGATCCTTC AGGTCTGGGGGAGGAGTCCCCAGATAATGCATAGATCTTTTAAACTCTTCACGTCAAACTGACATCTG CTTATGTAGCTCAGCTCAATGT GTTAGTCATTTTGTTTCGTTTATTATCAAACACATCTTCTGAAAAATG AGAAGAGGAAGGGAAAAAGGAGTCTGGGAAAGGACCACACTTTCTACCACCCCTGTAAACAGTGAG CTTTACTCTGCAATACACCAAGTGGAAGGACAGGCTATGAGATGGGCACAGTAAAGAGCCACCTA AGGGAAGTGGGCAGAACTCCAGAAGACT TCCTGAGGAGGCATTTATTCTTTATGAATCTTTGAAATGT TTTTTTAAATCATCTTTGATTTGACTTTTGCTTCTAAAAGTATCACAAGGTAAGACTCAGCTGTGAAACTA AGCACATCCGATAGTCAAACTATGAAAACTTTTACACGCTAGTGGGGCACTGTGACACCACTGATTTC CTTAAACTGAGCTCCTTTCAAGGTGTTTTGACCTAACTGG CCTTTGGGTCGGATATAGCTTTTACATAC TTTTG GTAGGT AACTACG G GTTCCTATTTGTC AGG G AAAGTGGGTAAG AGTT AG CTATTCCCC AC AAC CTTG ATAG C AGCTTATAAAG AG AG CC AGTGTC AAATC AATTTGTGCC AC AG G C ATTATTTTAAAAG C AT TTCTTAGAAAGCACACAGGAGTGTTCAGGCAAGAGGTACTGTAAGCCCTTTGCTTTTTCGGGGCTT ACAACCTCTCAATTTAAATGAAAGGTTTATTACACAAGGTATTGGTAACAGTGACCAGCAATAGGCTCT GCTGTGTTACTACTGGCATCAGTCAAAACATGTTCTGACCTCGTTTCTGTA TATGTTTATATGTTTAGA GGTCAAGCCCTGTGTGTCCTTTCTGAGGGCCATGTTAAAGGCCTCCTCAGATTCCTATACTCTATTCT TGCAAAGCTGGAGAGGTTCTTTAGAAGTATTTTAGCCGGGATACGTATATCGAATACCCTCAACTTCA CCAATGCAAGCCAGCTTCTAACATACTAATTAGCAAGCCACTGATTTTATCAATAAAAACCCATTTC TA ACATTTACTGTGGAATTAGCAAAGTTTCTGGTGTACATTGGATATGAAAGCTCCAGTAACAGACTCAG AAGAAATGGAGACCTGTGAAATGACAAATAATTTAGACTAATCCTCTTAAGTTCAACAAAGTACAAGAA AATATGGATAGAAAAATGAAATTTGGAAAACAACATCTGAACAGAATGAGAAGTTTAACAAATATAAAC AAAAACAATAGAAA TTCTAAAGATAAAGAATACAGTAACTGAACTGAAAATCTAAGTAGAACGCTTCAA CAGCAGACTTGATCAAGCAGAAGAATCAATGAGCTCAAAGGTAAGACATTTGAAATTATCCAATGAGA pncrnn / Lznz / B / YiAi 117 AAC AAAAAC AAAAAAG AATG CCTATAAG AATTAC AG G AC AC ATC AAG CTAG CTAACTTTTG C ATAATAG GAGGTCCTTAAGGAGAAAAGAAAAAAAAAAGGCCTAGAAAGCATATTTAAGGAAGTAATAGCTGAAAAA TTCCCAAATCTGAGAAAAGATGACAAAATTCAGGAACAGGAAGCTGAGGTCACCGATCAGATTCAAC CTAAAGAGTTCA CCAAGACACATCACAACCAAGTTATCAAAAATCAAAGACAAAGAATACTGAAAGCA GCAAAGATAAGAAACATCACATTCAAGGTAGCCCCAATACAGATTCAGTGGCTTTATCAGCAAAAGCC TTACAGGCCAGTAGAGAGTGGGATGGTATATTCAAAGTGCTGAAGGAACAAAGCTGTTAATTAAGAA TACTTTACTTGGCAAAGGGAGAA ATAAACACTTTTCCAGATAAACAATGCCTAAGGGAGTTTGTCACT ACTAGGCCTGCTCTACTGGAATTACTAAAAGGGAGTTCTTTAGGCTTAAATAAAAGACTGCTAGTTAAT GAGAAACATAAAAGTAAAAAACTAAATGGTATAAGTAATTCATAGTCAGAATTCTCTAGTATTGTAAAG GTGGCAGGTAAAGCAATGTTATTCCTATTAGGAGGTTTA AAAGATGAAACTATTAAAACAACTGTAG CTACAATAAGTTGTAGCTACAAGAAGTAATTGTAACTGTAGCTACAATAAGAGATACAAATTTAAAAAAA GTGTAAACTTTGACATCAAAATCACGAAAGGCGGGGGGGTTGTGAAAGCGTAGAGTTTTTGTATGCA ACTAAAGGCAAGTTTTTATCGCTTAAAGTAGCCTAAGGATAAAATGTTTTA AGTTAGCCTTACAGCAAA TACAATGGTAATCGCATATACTATAAAAGAAAGGATTCAAAGCACACCACCACAGAAAACCACCAAAC CACAAAGGAAGGTAGCAATAGGGAAAAAAAGAAACAAGGGACCTACAAAACAATCAGAAAACAAATTA CAAAATGACACTAGCAGTTTCTTACCAATAGTTACCTTGAATGTAAACGGATTAGATTTCCCAACAAAA AGACATAGA ATGACAGAATGGATTTTTTTTTTTTTTTAAGTCACAACCACATACTGCCTATAAGAGACT CACTTTTTTTTCTTTTTCTTTTTCTTTTTTTTGAGACGGAGTTTTGCTATTGTCAAGGCTGGAGTGCAATG GCATGATCTCAGCTCACCGCAACCTCCACCTCCCGGGTTTAAGCAATTTCCCTGCCTCAGCCTCTCG AGTAGCTGGGATTACAAGGGCC CACAACCACGCCTGGCTAATTTTGTATTTTTAATAGAGACAGGTTT TCTCCATGTTGGTCAGGCTGGTCTCTAACTCCCAACCTCTGGTGATCCCGCCGCCTTGGCCTCCCAA AGTGCTGGGATTACAGGAGTGAGCCACTGCGCCCGGCAAGAGATTCACTTTTCTACTAAACATACAC ATAGACTGAAAGTGAAGGGATGGAAAAAGATA TTCTATATAAATGGAAATTGAGAGCAGGGG...

Claims

1. A polynucleotide comprising a first nucleotide sequence encoding a short hairpin RNA (hRNA), ribozyme, or microRNA, wherein the hRNA, ribozyme, or microRNA is capable of inhibiting parental UBE3A silencing.

2. The polynucleotide according to claim 1, wherein the first nucleotide sequence encodes the hRNA.

3. The polynucleotide according to claim 1, wherein the hRNA comprises a second nucleotide sequence that is at least 85%, at least 90%, at least 95% or 100% complementary to an RNA encoded by either SEQ ID NO: 5 or SEQ ID NO: 9-508.

4. The polynucleotide according to claim 2 or 3, wherein the first nucleotide sequence is SEQ ID NO:

2.

5. The polynucleotide according to claim 1, wherein the first nucleotide sequence encodes the ribozyme.

6. The polynucleotide according to claim 5, wherein the ribozyme comprises a second nucleotide sequence at least 85%, at least 90%, at least 95% or 100% complementary to an RNA encoded by any of SEQ ID NO: 6 or 7.

7. The polynucleotide according to claim 5, wherein the first nucleotide sequence is SEQ ID NO: 3 or SEQ ID NO:

4.

8. The polynucleotide according to claim 1, wherein the first nucleotide sequence encodes the microRNA.

9. The polynucleotide according to claim 8, wherein the microRNA comprises a second nucleotide sequence at least 85%, at least 90%, at least 95% or 100% complementary to an RNA encoded by either SEQ ID NO: 5 or SEQ ID NO: 9-508.

10. The polynucleotide according to claim 8 or 9, wherein the first nucleotide sequence is SEQ ID NO:

8.

11. The polynucleotide according to any of claims 1 to 10, wherein the hRNA, ribozyme, or microRNA enhances the expression of paternal UBE3 A.

12. The polynucleotide according to any of claims 1 to 11, wherein the parental UBE3A comprises a nucleotide sequence of SEQ ID NO:

509.

13. The polynucleotide according to any of claims 1 to 12, wherein the silencing of the paternal UBE3 A is by means of the RNA transcript encoded by SEQ ID NO:

1.

14. An expression vector comprising the polynucleotide according to any of claims 1 to 13 and a promoter.

15. The expression vector according to claim 14, wherein the promoter is a U6 promoter.

16. The expression vector according to claim 14 or 15, wherein the polynucleotide is a DNA polynucleotide. encenn / Lznz / E / YiAi 120 17. The expression vector according to any of claims 14 to 16, wherein the expression vector is an adeno-associated viral vector (AAV) or a lentiviral vector.

18. A viral particle comprising the polynucleotide according to any of claims 1 to 13.

19. The viral particle according to claim 18, wherein the particle is an AAV particle or a lentiviral particle.

20. The viral particle according to claim 19, wherein the particle is an AAV particle with specific neurotropism.

21. The viral particle according to claim 19, wherein the particle is an AAV9 or AAV10 particle.

22. A pharmaceutical composition comprising the polynucleotide according to claims 1 to 13 or the viral particle according to any of claims 18 to 21 and a pharmaceutically acceptable carrier.

23. A method for treating Angelman syndrome comprising administering to a patient in need thereof, a therapeutically effective amount of the viral particle according to any of claims 18 to 21 or the pharmaceutical composition according to claim 22.

24. A method for activating or increasing the expression of the paternal UBE3A gene comprising administering to a patient in need thereof, a therapeutically effective amount of the viral particle according to any of claims 18 to 21 or the pharmaceutical composition according to claim 22.

25. A method for inhibiting the silencing of the paternal UBE3A gene by the antisense RNA transcript encoded by SEQ ID NO: 1 comprising administering to a patient in need thereof, a quantity of the viral particle according to any of claims 18 to 21 or the pharmaceutical composition according to claim 22 effective in cutting the antisense RNA transcript encoded by SEQ ID NO:

1.

26. The method according to any of claims 23 to 25, wherein the viral particle or the pharmaceutical composition is administered to the patient's brain.

27. The method according to any of claims 23 to 25, wherein the viral particle or the pharmaceutical composition is administered to the patient's neurons.

28. The method according to any of claims 23 to 27, wherein the patient is a human.

29. The method according to any of claims 23 to 28, wherein the hcRNA, ribozyme or microRNA inhibits the silencing of the paternal UBE3A gene by the antisense RNA transcript encoded by SEQ ID NO:

1.

30. The method according to any of claims 23 to 29, wherein the hRNA, ribozyme or microRNA interrupts the transcription of a polynucleotide comprising the sequence of SEQ ID NO:

1. encenn / ίζηζ / Β / γίΛΐ 121 31. The method according to any of claims 23 to 30, wherein the hRNA, ribozyme or microRNA decreases the levels of the antisense RNA transcript encoded by SEQ ID NO:

1.

32. The method according to any of claims 23 to 31, wherein the hRNA, ribozyme or microRNA cuts the antisense RNA transcript encoded by SEQ ID NO:

1.

33. The polynucleotide according to any one of claims 1 to 13, the viral particle according to any one of claims 18 to 21 or the pharmaceutical composition according to claim 22 for use in the treatment of Angelman syndrome, for use in activating paternal UBE3A, or for use in inhibiting the silencing of the paternal UBE3A gene by the antisense RNA transcript encoded by SEQ ID NO:

1.

34. The use of the polynucleotide according to any of claims 1 to 13, the viral particle according to any of claims 18 to 21 or the pharmaceutical composition according to claim 22, in the preparation of a medicament for the treatment of Angelman syndrome, to activate paternal UBE3A or to inhibit the silencing of the paternal UBE3A gene by the antisense RNA transcript encoded by SEQ ID NO:

1.

35. An hRNA, ribozyme, or microRNA encoded by the polynucleotide according to any of claims 1 to 13.