NEBULIZER, INDICATOR DEVICE AND CONTAINER.

Abstract

A nebulizer and a container with a fluid and an indicator device for the nebulizer are proposed. The indicator device prevents the container from being used again when a predetermined number of administrations is reached or exceeded. The nebulizer then partially opens, preventing further use. After replacing the container, which includes the indicator device, the nebulizer can be used again.

Description

NEBULIZER, INDICATOR DEVICE AND CONTAINER FIELD OF INVENTION The present invention relates to a nebulizer according to the preamble of claims 1, 5, 10 or 16, to an indicating device according to claim 20 and to a container according to the preamble of claims 28 or 29. BACKGROUND OF THE INVENTION WO 2012 / 162305 A1 describes a nebulizer. A container can be inserted into the nebulizer housing. The housing is closed by a lower portion. By rotating this lower portion, the drive spring can be tensioned, allowing fluid to enter the compression chamber of the pressure generator. Simultaneously, the container moves downward into the lower portion of the housing, and when tensioned for the first time, the base of the container can be pierced by a pointed element located at the bottom of the housing to allow for venting. Upon manual pressing of a button, the drive spring is released, and the outlet tube moves into the pressure chamber, whereupon the drive spring pressurizes the fluid, which is then delivered or atomized through a nozzle into a mouthpiece as an aerosol without the use of a propellant gas.Therefore, the container moves axially forward and backward while the fluid to be nebulized flows and during pressure generation and nebulization. The container can be inseparably connected to the housing piece by means of a fastening device and thus form a transport lock to keep the container immobile while in use. The nebulizer includes an indicator device for counting and / or displaying the number of administrations performed or remaining. The indicator device prevents the nebulizer from being reused in the closed state once a predetermined number of administrations has been reached or exceeded with the current canister. The canister can then be replaced along with a housing component, and the nebulizer can be used with the new canister. US 7,823,584 B2 describes a similar nebulizer, wherein a counting device can be integrated into a housing piece that is interchangeable or replaceable along with the container, which cannot be separated from the housing piece. WO 2007 / 104694 A1 describes a powder inhaler with an indicating device that may comprise a worm gear for driving an indicating element. BRIEF DESCRIPTION OF THE INVENTION The object of the present invention is to provide a nebulizer, as well as an indicating device, and a container for a nebulizer that allows for easy and / or safe use and handling and / or a compact and / or reliable structure, preferably, while allowing the replacement of the container without replacing any part of the nebulizer housing. The above object is achieved by means of a nebulizer according to claims 1, 5, 10 or 16, by means of an indicating device according to claim 20 or by means of a container according to claims 25 or 28. Preferred embodiments are the subject of the dependent claims. BRIEF DESCRIPTION OF THE FIGURES Other advantages, features, and aspects of the present invention will be evident from the claims and the following description of a preferred embodiment with reference to the figures. Example: Figure 1 shows a schematic cross-section of a known nebulizer in an untensioned state. Figure 2 shows a schematic cross-section, rotated 90° compared to Figure 1 of the known nebulizer in a tensioned state. Figure 3 shows a schematic cross-section of a nebulizer with a container inserted in an untensioned state according to a preferred embodiment of the present invention. Figure 4 shows a partial enlargement of the part of Figure 3 marked with a circle. Figure 5 shows a perspective view of the nebulizer cut according to Figure 3. Figure 6 shows an enlargement of the part of Figure 5 marked with a circle. Figure 7 shows a schematic exploded view of an indicating device according to a preferred embodiment of the present invention. Figure 8 shows an axial cross-section of the indicating device in the actuated state. Figure 9 shows an axial cross-section of the indicating device in the closed state. Figure 10 shows a perspective cross-section of the indicator device in the actuated state. Figure 11 shows a perspective cross-section of the indicator device in the released state. Figure 12 shows a partial magnification of the nebulizer similar to Figure 4, but in a partially tensioned state. Figure 13 shows a partial magnification of the nebulizer similar to Figure 4, but in a fully tensioned state. Figure 14 shows a partial cross-section of the nebulizer similar to Figure 4, but in an intermediate state during administration displacement. Figure 15 shows a partial cut of the nebulizer similar to Figure 4, but with an indicator device showing the container in a closed state. Figure 16 shows a schematic cross-section of the nebulizer in the closed state after the following tensioning with the housing piece partially open and with the locking device locked. Figure 17 shows a partial enlargement of the part of Figure 13 marked with a circle. Figure 18 shows a schematic cross-section of the nebulizer similar to Figure 3 with the locking device unlocked. Figure 19 shows a schematic cross-section of the indicator device in the initial state according to a modified mode. Figure 20 shows a perspective cross-section of the indicating device according to Figure 19. DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a nebulizer for nebulizing a fluid, preferably a liquid medication, from a preferably replaceable container holding the fluid, and refers to the container. Preferably, an indicator device is provided for counting and / or indicating the number of administrations performed or those remaining in the container in use. In particular, the indicator device or an associated locking device may lock the container and / or nebulizer or may cause the container and / or nebulizer to lock to prevent reuse in the closed state when a predetermined number of administrations with the respective container is reached or exceeded. Preferably, the nebulizer comprises a housing piece that can be separated from the nebulizer or opened to replace the container. According to one aspect of the present invention, the indicator device is preferably adapted to open at least partially, or to cause at least partial opening of the nebulizer and / or the housing component when it is in the closed state and / or when the closed state is reached, and / or the indicator device is adapted to prevent the complete closure of the nebulizer and / or the housing component when they are in the closed state. In particular, this allows for a very compact and simple structure and / or safe operation. Preferably, the number of parts and components required can be reduced. In particular, this allows for intuitive handling. According to another aspect of the present invention, the indicator device locks the entire assembly of the container with the nebulizer or with the nebulizer housing and / or the housing component in the closed position. In particular, this allows for a very compact and simple structure and / or safe operation. Preferably, the number of parts and components required can be reduced. In particular, this allows for intuitive handling. According to another aspect of the present invention, the indicator device is preferably adapted to prevent the complete insertion of the container into the nebulizer and / or the housing component in the closed position. This allows for a very compact and simple design and / or safe operation. Preferably, this enables intuitive handling. Preferably, this prevents the reuse or insertion of a previously used container and thus allows for a very simple and safe design. According to another aspect of the present invention, the indicator device is preferably adapted to block all axial and downward movement of the container within the nebulizer when closed. This allows for a very compact and simple structure. Preferably, the number of parts and components required can be reduced. Furthermore, this enables safe operation. Preferably, the nebulizer and / or the container cannot be reused in the closed state when the indicator device detects that a predetermined number of administrations has been reached or exceeded, particularly with the respective container. The indicator device can directly or indirectly close, initiate, or cause the closure of the nebulizer and / or the container to prevent reuse. Specifically, the indicator device can directly actuate the locking device or indirectly initiate its activation. Preferably, indirect activation is achieved by at least partially opening the nebulizer, the housing, or a part of the housing to lock the nebulizer and prevent reuse with the current container. Preferably, the nebulizer locks (automatically) to prevent it from being used again or tightened if the nebulizer housing or housing part is open or at least partially open, or if, in other words, the nebulizer or its housing is not (completely) closed. It is also possible that the nebulizer will not immediately lock to prevent reuse when the indicator device is in the closed state. Conversely, the indicator device may initiate, cause, or trigger the locking device to lock the nebulizer to prevent reuse, for example, during the next actuation, tightening, or similar action. Therefore, the locking device may initiate the closed state later, for example, after at least partial opening of the nebulizer and / or at least partial tightening of the nebulizer, or rotation of a housing component or internal part of the nebulizer, or similar actions. Therefore, the indicator device can initiate or cause the nebulizer to lock not only indirectly, but also, alternatively or additionally, later during handling, operation, activation, or similar activities. In the latter case, the indicator device locks or initiates or causes the nebulizer and / or the container to prevent its reuse, preferably in the sense of the present invention. Preferably, the nebulizer closure to prevent reuse can be reversed by replacing the container, in particular the one that includes the indicator device, with one that has not been used. According to another aspect of the present invention, the indicator device is preferably inseparably connected to the container or to a container housing, but it can be separated from the nebulizer or its housing and from the housing component, so that the indicator device can be replaced together with the container. This allows the nebulizer and housing component to be reused with another container that includes a different indicator device. Therefore, the overall size of the interchangeable components is small, resulting in compact replacement packs that facilitate the transport of large quantities. Preferably, the indicator device is fixed to the bottom of the container and / or opposite an outlet. This allows for a very compact design. Furthermore, the indicator device does not interfere with the flow of fluids between the container and the nebulizer. According to another aspect of the present invention, the indicating device preferably comprises an insertion opening for a drive element to actuate or initiate the counting or indicator of the indicating device, wherein the indicating device is adapted to lock or close the insertion opening in a closed state when a predetermined number of counts is reached or exceeded. In particular, this allows for a very compact or simple structure and / or safe operation. Preferably, the indicating device comprises an indicator element and an actuating element for adjusting the indicator element. In particular, the indicator element displays an indication of the number of doses administered or remaining in the respective container. Preferably, a linear movement of the actuating element causes a rotational movement of the indicating element. Even more preferably, the drive element is set in motion by a relative longitudinal movement between the container with the indicating device and the housing and / or housing part of the nebulizer. According to another aspect of the present invention, the actuating element in the indicating device is preferably designed to also prevent reuse of the container in the closed state. In particular, this allows for a very compact and simple structure and / or safe operation. Preferably, the number of parts and components required can be reduced. According to another aspect of the present invention, the actuating element can preferably be moved forward and backward between a first and a second position to adjust the indicator element and can be moved—at least once—to a third position to prevent the container from being reused in the closed state. In particular, this allows for a very compact and simple structure and / or safe operation. Preferably, the number of parts and components required can be reduced. According to another aspect of the present invention, the drive element can preferably be moved transversely or longitudinally, either towards the outlet of the container or nebulizer. This allows for a very compact and simple structure and / or safe operation. Preferably, the number of parts and components required can be reduced. Preferably, the indicator device comprises a locking piece that prevents the container and / or nebulizer from being reused in the closed state. According to another aspect of the present invention, the locking piece is preferably formed or entirely constituted by the actuating element. In particular, this allows for a very compact and simple structure and / or safe operation. Preferably, the number of parts and components required can be reduced. According to another aspect of the present invention, the locking piece is preferably integrated into the housing of the indicating device. In particular, this allows for a very compact and simple structure and / or safe operation. Preferably, the number of parts and components required can be reduced. According to another aspect of the present invention, the locking piece can preferably be moved transversely or longitudinally, or towards the outlet of the container or nebulizer. In particular, this allows for a very compact and simple structure and / or safe operation. Preferably, the number of parts and components required can be reduced. According to another aspect of the present invention, the locking piece preferably closes an insertion opening of the indicator device or its housing when closed. In particular, when unlocked, the insertion opening receives a drive element attached to the housing or a part of the nebulizer housing. Through relative movement between the indicator housing and / or the container and the nebulizer housing, the drive element actuates the indicator device, specifically to count and / or indicate nebulizer usage on the indicator device. This allows for a very compact and simple design and / or safe operation. Preferably, the number of parts and components required can be reduced. According to another aspect of the present invention, the locking piece preferably actuates a closing device or its closing element of the nebulizer in the closed state. This actuation can be effected directly by the respective cooperation of the locking piece of the closing device or its closing element, or, in particular, alternatively and indirectly, by opening the nebulizer or closing an insertion opening of the indicating device, or similarly, thereby actuating the closing device or its closing element. Therefore, a new use, in particular, a new administration or nebulization of fluid, can be prevented or blocked in the closed state. The above aspects of the present invention and other aspects described below can be carried out independently of each other and in any combination. In the figures, the same reference numbers are used for identical or similar parts, resulting, preferably, in corresponding or comparable properties or advantages, even if the associated description is not repeated. Figures 1 and 2 show a nebulizer 1 known for atomizing a fluid 2, in particular a highly effective pharmaceutical composition or drug, or the like, shown schematically in an unstressed state (Figure 1) and in a stressed state (Figure 2). The nebulizer 1 is constructed, in particular, as a portable inhaler and preferably operates mechanically only and / or without propellant gas. When the fluid 2, preferably a liquid, more particularly a pharmaceutical composition, is nebulized, formed, or delivered as an aerosol 14 (Figure 1), the user can aspirate or inhale it. Inhalation is usually performed at least once a day, more particularly several times a day, preferably at specified intervals, depending on the patient's symptoms or condition. The nebulizer 1 contains or comprises an insertable or replaceable container 3 that holds the fluid 2. The container 3 thus constitutes a reservoir for the fluid 2 to be nebulized. Preferably, the container 3 holds multiple doses of fluid 2 or an active substance, in particular, sufficient to provide up to 200 dosage units or doses, i.e., to allow up to 200 sprays or applications. A typical container 3, as described in WO 96 / 06011 A1, holds, for example, a volume of approximately 2 to 20 mL. Likewise, the number of doses contained in container 3 and / or the total volume of fluid 2 contained in container 3 may vary depending on the fluid 2 or the respective medication and / or depending on container 3 and / or depending on the medication required or similar. Preferably, the container 3 can be replaced or interchanged, wherein the total number of uses of the nebulizer 1 and, therefore, the number of containers 3 that can be used with the same nebulizer 1 are, preferably, limited, for example, to a total of 4 or 5 containers 3. Additionally, WO 2012 / 162305 A1 describes a similar limitation on the total number of containers 3 that can be used with the same nebulizer 1. Preferably, the container 3 is substantially cylindrical or cartridge-shaped, and once the nebulizer 1 is opened, the container 3 can be inserted into it, preferably from below, and can be changed if desired. Preferably, it is of rigid construction, and the fluid 2, in particular, is contained in a compressible bag 4 within the container 3. In particular, the container 3 includes a vent opening or hole 23 that is opened before or during first use. The nebulizer 1 comprises a delivery mechanism, preferably a pressure generator 5, for transporting and nebulizing the fluid 2, in particular, in a predetermined amount of optionally adjustable dose. The nebulizer 1 or the pressure generator 5 preferably comprises a support 6 for holding the container 3 in a manner that allows release, a drive spring 7 associated with the support 6 (shown only partially), and / or a locking element 8, preferably in the form of a button or with a button for manual actuation or pressing. The locking element 8 can retain and lock the support 6 and can be manually operated to release the support 6, allowing the drive spring 7 to expand. The nebulizer 1 or the pressure generator 5 preferably comprises a transport element, such as a transport tube 9, a check valve 10, a pressure chamber 11 and / or a nozzle 12 for nebulizing the fluid 2 towards the mouthpiece 13. The fully inserted container 3 is fixed or held in the nebulizer 1 by means of the support 6, so that the transport element connects in such a way as to allow the conduction of fluids from the container 3 to the nebulizer 1 or to the pressure generator 5. Preferably, the transport tube 9 penetrates the container 3. The nebulizer 1 or the stand 6 are preferably constructed so that the container 3 can be replaced. When the drive spring 7 is axially tensioned during the tensioning process, the support 6, along with the container 3 and the delivery tube 9, moves downward as shown in the figures, and fluid 2 is drawn from the container 3 into the pressure chamber 11 of the pressure generator 5 through the check valve 10. In this state, the locking element 8 retains the support 6 so that the drive spring 7 remains compressed. At this point, the nebulizer 1 is in the tensioned state. During the subsequent relaxation phase of the nebulization process, following the activation or pressure of the locking element 8, the fluid 2 in the pressure chamber 11 is pressurized. Meanwhile, the delivery tube 9, with the now-closed check valve 10, retracts upward into the pressure chamber 11, as shown in the figures herein, due to the relaxation or force of the drive spring 7, functioning as a hydraulic cylinder or piston. This pressure forces the fluid 2 through the nozzle 12, at which point it is nebulized as an aerosol 14, as shown in Figure 1, and thus delivered. In general, the nebulizer 1 operates with a spring pressure of 5 to 200 MPa, preferably 10 to 100 MPa, on the fluid 2 and / or with a dosed volume of fluid 2 of 10 to 50 µL, preferably 10 to 20 µL, more preferably approximately 15 µL. The fluid 2 is converted into aerosol 14 or nebulized as an aerosol 14, the droplets of which have an aerodynamic diameter of up to 20 µm, preferably 3 to 10 µm. Preferably, the generated spray has an angle of 20° to 160°, preferably 80° to 100°. These values ​​also apply to the nebulizer f, according to the explanations of the present invention, as particularly preferred values. The user or patient (not shown) can inhale the aerosol 14, preferably, while the air supply can be drawn into the mouthpiece 13 through at least one optional air supply opening 15. The nebulizer 1 preferably comprises a housing 24 and / or an (upper) part of the housing ML / a / ZUZZ / UUDUI oy, optionally, a movable or internal part 17 which is preferably rotatable with respect to this (Figure 2) and / or has an upper part 17a and a lower part 17b (Figure 1). The nebulizer 1 or the housing 24 preferably comprises a (lower) part of the housing 18. In particular, part 18 is used and / or removed manually; in particular, it is secured or attached to the inner part 17, preferably by means of a retaining element 19. Preferably, housing parts 16 and 18 and / or other parts form housing 24 of nebulizer 1. In order to insert and / or replace the container 3, the housing 24 can preferably be opened and / or the housing part 18 can be removed from the nebulizer 1, from the inner part 17 or from the housing 24. In general and preferably, the container 3 can be inserted before the housing 24 is closed and / or before the housing piece 18 is connected to the housing 24. The container 3 can be inserted, opened, and / or connected so as to allow fluid conduction with the administration mechanism automatically or simultaneously when the housing piece 18 is (fully) connected to the housing 24 / nebulizer 1 and / or when the housing 24 / nebulizer 1 is (fully) closed. Preferably, the container 3 opens or connects so as to allow fluid conduction when the nebulizer 1 is first tightened with the current container 3. Preferably, the nebulizer 1 or the drive spring 7 can be manually actuated, tensioned or loaded, in particular by actuating a drive member, preferably, in the present case, by rotating the housing part 18 or any other component.The drive member, preferably the housing part 18, can be driven, in this instance, to rotate relative to the upper part of the housing 16, thereby driving or driving the internal part 17. The internal part 17 acts on a gear or transmission to transform the rotation into axial motion. As a result, the drive spring 7 is tensioned axially by means of the gear or transmission (not shown) formed between the internal part 17, in particular the upper part 17a, and the support 6, and acts on the support 6. During tensioning, the container 3 moves axially downwards until it reaches a final position as shown in Figure 2. In this activated or tensioned state, the drive spring 7 is tensioned, and the locking element 8 can retain it.During the nebulization process, the container 3 returns to its starting position (untensioned position or state, as shown in Figure 1) by means of the drive spring 7. Therefore, the container 3 rises or performs a downward movement during the tensioning process and during the nebulization process. The housing piece 18 preferably constitutes a lower housing portion shaped like a lid and / or fits or is placed over the lower free end of the container 3. While the drive spring 7 is being tensioned, the container 3 moves together with the (further) end towards the housing piece 18 or towards the end side thereof, while a ventilation means, such as an axially actuated spring 20 disposed in the housing piece 18, comes into contact with the base 21 of the container 3 and pierces the container 3 or a closure or aluminum sheet 50 at the base with a pointed element 22 when the container 3 first comes into contact with it, to allow the entry of air or ventilation, preferably by opening or piercing a vent hole 23.The vent hole allows for pressure compensation within container 3 when fluid 2 is drawn from container 3 during operation of nebulizer 1. The nebulizer 1 preferably comprises an indicating device 25, which counts, in particular, the actuations of the nebulizer 1, preferably by detecting the tension or rotation of the inner part 17 with respect to the upper part 16 or the housing 24. Preferably, the counting device 25 or an associated closing device 26 closes the nebulizer 1 to prevent (additional) actuation or use, for example, by blocking further rotation of the housing part 18 / the inner part 17, and thereby tensioning the nebulizer 1 or its drive spring 7 and / or blocking the actuation of the locking element 8 in a closed state when a predetermined number of actuations, operations, or dosages is reached or exceeded. Below, and with reference to other figures, a preferred embodiment of the nebulizer 1, the container 3, the indicating device 25 and / or the closing device 26 is described and shown according to the invention, wherein the principally important aspects and differences are described, and the above aspects, features and explanations are preferably applied additionally or correspondingly even without being repeated. Figure 3 shows the nebulizer 1 with the container 3 and the indicating device 25 according to the present invention in a schematic cross-section (longitudinal cut) in the untensioned state with the nebulizer housing 24 fully closed, and therefore the housing piece 18 closed, wherein the proposed container 3 and indicating device 25 are inserted or received within the nebulizer 1 and / or the housing 24. Figure 4 shows a close-up of a partial cross-section of the circled portion of Figure 3. Figure 5 shows a perspective view of the cross-section of nebulizer 1 from Figure 3. Figure 6 shows a close-up of a partial cross-section of the circled portion of Figure 5. Preferably, the nebulizer 1 has a shape or longitudinal axis that corresponds to the axial direction and / or the main outlet direction and / or the downward movement of the container 3 during tensioning and administration. In the described untensioned state, the nebulizer 1 or its mouthpiece 13 is preferably closed with a mouthpiece cap 27. Preferably, the mouthpiece cap 27 is pivotable to allow the mouthpiece 13 to be opened for use of the nebulizer 1. Preferably, the indicator device 25 is secured or fixed directly and / or immovably to or connected to the container 3. In particular, the indicator device 25 is associated with a respective container 3. If the container 3 of nebulizer 1 is replaced, the indicator device 25 must also be replaced. Preferably, the indicator device 25 is fixedly arranged at the bottom or base 21 of the container 3 and / or opposite an outlet or top 28 of the container 3. In the present embodiment, the indicating device 25 is preferably connected directly to an external housing or, preferably, a rigid housing 29 of the container 3 or spliced ​​into it. Preferably, the indicator device 25 and the container 3 are connected by form fit and / or push fit. In particular, the indicating device 25 surrounds and / or is attached to a rim 30 (lower or bottom) and / or any other projection of the container 3 or similar. In the present embodiment, the rim 30 is slightly wider in diameter, so that it projects radially from the essentially cylindrical external shape of the side walls of the container 3 / of the housing of the container 29. Preferably, the diameter of the indicating device 25 is at least essentially equal to or only slightly larger than the diameter of the container 3 or that of its rim 30. Preferably, the rim 30 is formed between the side wall and the bottom or base 21 of the container 3 or the casing of the container 29. Preferably, the rim 30 is formed by flanging, beading, curving or folding, or any other suitable material deformation process. The indicating device 25 comprises a housing 31 and / or preferably has at least an essentially cylindrical shape. Preferably, the indicating device 25 or its housing 31 are attached to the container 3 or its base 21 or housing 29 by means of at least one essentially flat and / or axial side. Preferably, the indicating device 25 or its housing 31 comprises a clamping or support area 32 for connecting the indicating device 25 to the container 3. Preferably, the clamping area 32 surrounds the rim 30 and / or is attached to the rim 30. In the present modalities, the clamping area 32 is preferably annular and / or is attached to the rim 31 in positions distributed around the circumference of the rim 30 or container 3. Preferably, the indicating device 25 and the container 3 are connected to each other by a snap fit or clamp connection. Preferably, the container 3 and the indicating device 25 are connected to each other by an axial joint. Preferably, the clamping area 32 is sufficiently elastic in the radial direction so that the container 3 can be inserted axially with its rim 30. In the present embodiment, the clamping area 32 preferably comprises an insertion side respectively inclined to facilitate the insertion of the rim 30 into the annular clamping area 32 or between circumferentially distributed clamping areas 32. It should be noted that other construction solutions are possible for connecting the container 3 or its housing 29 to the indicating device 25 or its housing 31, or vice versa. Specifically, the two parts can be connected to each other, either additionally or alternatively, by welding, brazing, gluing, screws, staples, hot pressing, or similar methods. Figure 7 shows a schematic exploded view of the indicator device 25 according to the preferred embodiment of the present invention. The indicator or its housing 31 preferably comprises an upper part 33 and a lower part 34. Preferably, the upper part 33 contains or constitutes the clamping area 32. The indicating device 25 preferably comprises an indicating element 35 and an associated drive element 36 and / or a transmission 40 or a gear 41 for adjusting the indicating element 35 or for starting the adjustment of the indicating element 35. The indicator device 25 serves to count and / or indicate the number of administrations made or remaining available in the respective or associated container 3. Preferably, the indicator element 35 comprises markings 37, such as one or more symbols, numbers, colored or shaded areas, or the like, to indicate, at least approximately, the number of administrations made or remaining available in the respective container 3. In the present embodiment, the indicator element 35 is preferably rotatable and / or comprises a circumferential wall or external surface with at least one marking 37. The indicator housing 31 preferably comprises a viewer 31a, in particular on the circumferential wall through which the user or patient can see the relevant mark 37, preferably through the housing part 18 which is, in particular, transparent. Preferably, the drive element 36 comprises a drive arm 38 which internally comprises, preferably, a drive or free end 39 for directly or indirectly actuating or adjusting the indicator element 35. Adjusting implies that the indicator element 35 moves forward progressively. An indirect drive or impulse is preferred, so that the drive element 36 or its arm 38 drives or impels the indicating element 35 by means of a transmission 40. In the present embodiment, the transmission 40 produces a reduction and / or is implemented as a worm gear device. Preferably, the indicating device 25 or the transmission 40 comprises a gear 41 and / or a worm gear 42. More preferably, the worm gear 42 is formed directly from the gear 41, such that the gear 41 forms a worm gear and, preferably, comprises radially projecting teeth 43, where at least one turn of the worm gear 42 is generated (compare the horizontal or axial cross-sections of the positioned indicating device 25 shown in Figures 8 and 9). Preferably, the gear 41 comprises a shaft, in particular, one or more shaft areas 44 that can protrude axially on opposite sides as described herein. The drive element 36 causes the gear 41 to rotate about an axis preferably perpendicular to the direction of movement of the drive element 36; the axis is preferably arranged in a horizontal plane identical to or parallel to the plane provided by the movement of the drive element 36. The gear 41 is rotatable and is preferably supported by the housing 31 or the lower part 34 of the housing, preferably by two support areas 45 of the lower part 34. Preferably, the support areas 45 comprise cavities to support and allow rotation of the shaft areas 44. However, other construction solutions are also possible. Preferably, the housing 31 or the lower portion 34 supports the indicating element 35 so that it can rotate. In the present embodiment, the lower portion 34 preferably comprises two support fragments 46 arranged on opposite radial sides and projecting axially to support the indicating element 35 so that it can rotate. The drive element 35 and / or the transmission 40 are preferably arranged at least substantially between the support fragments 46. Preferably, the indicating device 25 comprises an actuating spring 47, in ML / a / ZUZZ / ULDUI or particular, to move the drive element 36 in a preferred direction and / or to drive the indicator element 35 Figure 8 shows a horizontal or axial cross-section of the indicator device 25 mounted in the actuated state, where the actuating element 36 is moved or pushed to one side, namely from the first position shown in Figures 3 to 6 to the left to a second position shown in Figure 8. Figure 9 shows a cross-section similar to Figure 8 of the indicator device 25 in the closed state, where the actuating element 36 is in a third closed position. As can be seen in Figures 8 and 9, the projections 60 of the indicating element 35 (not shown in Figures 8 and 9) extend axially, with the worm gear 42 always retaining at least one projection 60, thus forming a worm gear drive between the gear 41 and the indicating element 35. Therefore, any rotation of the gear 41 is transformed into a reduced rotation of the indicating element 35. Furthermore, permanent engagement between the gear 41 and the indicating element 35 is guaranteed, more precisely, between at least one projection 60 and the worm gear 42. However, other construction solutions or engagements between the gear 41 and the indicating element 35 are possible. Figure 10 shows a perspective cut of the indicator device 25 mounted in the first position and start state. Figure 11 shows a similar perspective cut of the indicator device 25, but with the actuating element 36 released, i.e., just before the closing state begins. Preferably, the transmission 40 or the gear 41 forms a worm (helical groove) 42 with at least one turn, preferably approximately 1.5 or more turns, such that at least one coupling element of the indicating element 35 or of any other transmission component, in particular the inwardly or axially projecting projection 60, always engages with the worm 42. Therefore, the rotation of the gear 41 about its preferably transverse axis causes the indicating element 35 to rotate about its preferably longitudinally oriented axis of rotation. However, other design solutions are also possible. Preferably, the teeth 43 are relatively long and / or extend sufficiently radially so that the projections are securely guided within the convolutions of the worm gear 42, between the teeth 43, and so that the drive element 39 can still move radially between the projection 60 that engages the worm gear 42 and the gear 41 in order to drive or rotate the gear 41 as desired. For this purpose, the drive element 39 can be engaged in correspondingly deep recesses between the teeth 43 so that it can move beneath the respective projection 60. Preferably, the indicating device 25 comprises a piercing piece 48 (compare Figures 3 to 6). The piercing piece 48 is arranged inside the indicating device 25 or its housing 31. Preferably, the punching piece 48 can be moved axially. Preferably, the piercing piece 48 can be moved so that it can protrude into the container 3 and / or open a vent opening, preferably the vent hole 23, of the container 3, in particular by breaking or piercing an aluminum sheet 50 covering the vent hole 23. In the present embodiment, the piercing element 48 preferably comprises an opening end or point 49 that can open or pierce the aluminum sheet 50 covering the base of the container 21, in particular, a slit 51 formed in the container 3 or its base 21. Preferably, the slit 51 comprises a cutout forming the ventilation hole 23. However, other construction solutions are also possible. Figure 12 shows a partial magnification similar to Figure 4 of a lower portion of nebulizer 1 in an intermediate state after partial tensioning. The indicator device 25 is in the actuated state as shown in Figure 8 (second position). Preferably, the nebulizer 1 or the housing part 18 comprises a drive part 52 for driving or actuating the indicator device 25 when using the nebulizer 1, in particular, to actuate the indicator device 25 in response to the tensioning of the nebulizer 1 and / or any movement (axial or downward) of the container 3. Preferably, the drive piece 52 is arranged or formed in the housing piece 18, in particular on the axial end side or at the bottom 53 of the housing piece 18. Preferably, the drive piece 52 is centered and / or extends axially. Preferably, the drive piece 52 is at least substantially cylindrical and / or pin or screw shaped. Preferably, the drive piece 52 is supported by the housing piece 18 and / or is entirely formed by the housing piece 18. In the preferred mode, the movement of the container 3 and therefore of the indicating device 25 during tensioning (in the figures, downward movement) and / or during pressurization and administration (in the figures, upward movement) and / or one or both of the respective end positions in the untensioned and tensioned states, respectively, can be used to actuate the indicating device 25, i.e., for counting. Preferably, the relative movement of the container 3 and / or the indicator device 25 within the nebulizer 1 and, more preferably, the movement during administration is used to actuate or initiate the indicator device 25 and / or the count. When the nebulizer 1 is tightened and / or the indicator device 25 is moved downwards, the drive piece 25 enters through an insertion opening 54 of the indicator device 25 or its housing 31, in particular axially, or couples with it. Preferably, the drive piece 52 and the insertion opening 54 are centered and / or axially aligned. In the present mode, the drive piece 52 actuates the drive element 36, i.e., it moves the drive element 36 from a first starting position, shown in Figures 3 to 6, to a second actuated position shown in Figure 9. Preferably, the drive spring 47 moves the drive element 36 to the first position. In the present embodiment, the drive element 36 can be moved forward and backward between the first and second positions to adjust the indicator element 35, in particular, to gradually rotate the gear 41 in one direction to drive the indicator element 35 respectively. Just as any rotation of the gear 41 is transformed into a reduced rotation of the indicator element 35, any movement of the drive element 36, from the first to the second position or vice versa, causes the movement of the indicator element 35. In the present embodiment, the drive element 36 can be moved transversely, preferably perpendicularly, to the longitudinal or exit direction of the container 3 or the nebulizer 1 and / or to the downward movement of the container 3 and / or the indicating device 25. Preferably, the drive element 36 moves from the first more central position radially outwards to the second position, in particular against the force of the drive spring 47, preferably helical, associated, moving the drive element 36 in the opposite direction. In the second position, the drive element 36 was moved with its drive arm 38 or drive fragment 39 outward coupling with the gear 41 as shown in Figures 8 and 12. Figure 13 shows an enlargement of the cut similar to Figure 12 of the fully tensioned state. In the (fully) tensioned state, container 3, more precisely, the opening or vent hole 23, opens at least when nebulizer 1 is tensioned with container 3 for the first time. Preferably, the opening of the container 3 or the ventilation hole 23 to allow the entry of air is made by piercing or breaking, in particular, the aluminum foil 50. The opening or perforation can be carried out directly by means of the drive piece 52. Alternatively, the opening or perforation can be carried out independently of the drive piece 52, for example, by means of the ventilation spring 20 with the punching element 22 similar to the embodiment shown in Figure 2. Alternatively, as indicated in the present embodiment, the opening or perforation can be achieved indirectly, preferably by means of the punching piece 48 which actuates it, preferably the drive piece 52. Preferably, the piercing piece 48 forms a separate piece and / or is provided by the indicating device 25 and / or is disposed within the indicating device 25. In the preferred embodiment, the punching piece 48 is held axially movable by a support structure 55 of the indicating device 25, the housing 31, the top part 32 and / or the indicating element 35, as shown schematically in Figures 10 and 11. Preferably, the piercing piece 48 and / or the support structure 55 are a one-piece structure with an additional piece of the indicating devices 25, for example, with the indicating element 35 or with the indicator housing 31, in particular with the upper part 33 of the indicator housing 31. Preferably, the piercing piece 48, the support structure 55 and the additional part of the indicating device 25 are made of plastic in an injection molding process. Preferably, the support structure 55 comprises flexible arms or fins to support the punching piece 48 so that it can be moved axially. ML / a / ZUZZ / UUDUI or Alternatively, the piercing piece 48 can be constructed as a separate, axially movable piece that can be moved longitudinally or axially out of the container 3, optionally by means of a spring, so that the piercing tip 49 retracts from the container 3 in an untensioned state. It should be noted that the pointed piece 48 or its tip 49 are preferably received inside the indicating device 25 or its housing 31, but may protrude outwards in the actuated state. The opening or perforation can be repeated each time the nebulizer 1 is tensioned, i.e., each time the container 3 takes its final position in the tensioned state. Preferably, the punching piece 48 can be moved to its retraction or starting position shown in Figures 3 to 6, in particular by means of a moving arm or spring, or the like, entirely formed, preferably, by means of the support structure 55. The punching piece 48 may include a compensating element, such as a flexible arm 56, to compensate for tolerances in the axial direction. Such tolerances may occur, in particular, due to variations during production, specifically variations in the length of the bowl 3 and / or other components, variations in the connections of the bowl 3 to the indicating device 25, variations in the length of the indicating device 25 or its housing 31, variations in the axial position of the bowl 3 within the support 6, and the like. Consequently, different distances may occur between the free end of the drive piece 52 and the opposite side of the punching piece 48. The construction is such that the drive piece 52 and the punching piece 48 cooperate in all cases, ensuring the desired perforation. The compensating fragment allows axial compression—in this instance, by radial bending of the arms 56—when a predetermined axial force is exceeded, in order to prevent damage to the container 3 and / or any other component of the nebulizer 1. Therefore, in the preferred embodiment, the drive piece 52 first moves the piercing piece 48 toward the base of the container 21 to the piercing position, and the further axial movement of the drive piece 52 is compensated by the compensating fragment, preferably by means of radially extending flexible arms 56, which allow the tip of the drive piece 52 to enter a central cavity in the piercing piece 48 (on the side opposite the piercing tip 49). Preferably, the punching piece 48 comprises at least one axial channel, in particular one or more slots 57 extending axially and distributed circumferentially around the circumference of the tip 49, in order to ensure that ventilation is not blocked even if the punching piece 48 becomes stuck or remains in the aluminum sheet 50 or in the piercing position. Figure 14 shows a magnification similar to Figures 4, 12, and 13 of an intermediate state of pressurization or administration process, i.e., when the vessel 3 is partially moved upward again. In this state, the drive piece 52 is withdrawn from the indicating device 25 or through the insertion opening 54 partially so that the drive element 36 begins to return to its first or starting position due to the force of the drive spring 47. Finally, after the drive piece 52 has retracted sufficiently, the drive element 36 returns to the first position shown in Figures 3 to 6 when the retraction movement is complete. The return movement of the container 3 and / or the drive element 36 preferably actuates the indicating device 25 or the gear 41 and / or is detected or counted. In particular, the drive element 36 or its arm 38 or the drive segment 39 transmits the return movement or the movement from the second to the first position to the transmission 40. In particular, this movement causes a progressive rotation of the gear 41. Therefore, in the present modality, the movement of the container 3 and / or the indicator device 25 within the nebulizer 1 during administration is used, preferably, to activate or start the indicator device 25 and / or for counting. In the present embodiment, the drive arm 38 or its fragment 39 engages with a tooth 43 of gear 41 during the return movement and, therefore, gear 41 rotates, due to the return movement, one more step, in the figures, in the clockwise direction. Preferably, the indicating device 25 comprises a ratchet 5 that prevents reverse rotation of the transmission 40 or the gear 41. In the present embodiment, the ratchet 58 constitutes a flexible arm extending from the housing 31, in particular the lower part 34 of the housing and / or engaging or coupling with the gear 41 or its teeth 43. In the final position, i.e., in the untensioned state, the drive piece 52 is preferably additionally or completely retracted from the indicator device 25, the indicator housing 31 and / or the insertion opening 54 as shown in Figures 3 to 6. The transmission 40 or gear 41 transforms the drive, in particular the (return) movement of the drive element 36 or its arm 38 / its drive segment 39, into the graduation of the indicating element 35. The transmission ratio or drive function of the transmission 40 or gear 41 can be designed or constructed to achieve a non-linear reduction or drive or graduation. In the present embodiment, the transmission 40 or gear 41 preferably constitutes a worm gear drive to achieve the desired reduction. The movement of the drive element 36 – in particular, from the first position to the second – causes the drive arm 38 or its drive segment 39 to disengage from the engagement with the gear 41, specifically, to move to the next tooth 43. At that moment, the arm 38 flexes outwards. The subsequent movement in the opposite direction, i.e., the return movement or the movement from the second to the first position, causes the drive arm 38 or its drive segment 39 to engage with the next tooth 41 and transmit the linear motion of the arm 38, more precisely, the preferably linear motion of the drive element 36, to a rotation of the gear 41, more precisely, by a gear 41, preferably by tooth 43. Preferably, the teeth 43 are asymmetrical, i.e., they comprise flanges with different inclinations on one side and the other in order to facilitate and / or ensure progressive drive and movement in a rotational direction by means of back-and-forth movement and engagement of the drive arm 38. Preferably, the drive element 36 can be moved linearly and / or constitutes a sliding carriage. Preferably, the drive element 36 is supported and / or held in a movable position by the housing 31, in particular the lower part 34 of the housing 31. However, other construction solutions are also possible. The drive spring 47 preferably operates between the housing 31 or the lower part 34, on the one hand, and the drive element 36, on the other hand. In the present embodiment, the spring 47 is preferably compressed and / or moved to the first position and / or moves the actuating element 36, so that it at least partially closes or blocks the insertion opening 54. Preferably, the drive element 36 comprises a sliding surface 59 inclined over the portion protecting the insertion opening 32 in the first position. This surface 59 is inclined so that the insertion of the drive piece 52, i.e., its axial movement or engagement, is transformed into a transverse or radial movement of the drive element 36. Alternatively, the surface 59 can also be formed on the drive piece 52 to achieve the desired transformation of axial motion into transverse or radial motion by means of an inclined plane. Therefore, the drive or rotation of the transmission 40 or gear 41 is preferably achieved by the force of the drive spring 47 or any other pressure or energy storage or spring means. This is advantageous since no additional force is required to drive the indicating device 25 or its indicating element 35. Consequently, the pressurization and administration process remain unaffected. Additionally, the start of the count or the actuation of the transmission 40 / gear 41 is preferably executed by pressurization or administration process or movement, i.e., during the actual administration of fluid 2, i.e., in general, during actual use or inhalation. The drive spring 47 moves the drive element 36, preferably to close the insertion opening 54. In general, the movement of the actuating element 36 is limited so that the insertion opening 54 does not close completely before the closed state is reached. This limitation is preferably achieved in this embodiment by means of a control element or fragment 62 against which a control piece 63 is spliced, in particular to limit the return movement of the actuating element 36 in the first position. The joint is shown, in particular, in Figure 10. However, other construction solutions are also possible. After the number of administrations of nebulizer 1 with container 3 reaches or exceeds a predetermined number of administrations as detected or recorded by the indicator device 25, a shutdown state is initiated, and nebulizer 1 will lock to prevent it from being used again with the current container 3 and / or container 3 will lock to prevent it from being used again with nebulizer 1. In particular, the indicating device 25 comprises a locking piece 61 that prevents reuse of the container 3 and / or closes or locks the insertion opening 54 in the closed state, as shown in the schematic enlargement of Figure 15, which shows a piece similar to Figures 4 and 12 to 14. In the described state, the container 3 returns to its untensioned position, and the drive piece 52 retracts from the indicating device 25. During the final administration or pressurization process, the indicating device 25 moves the indicating element 35 one step further and detects or registers that the predetermined number of administrations has been reached or exceeded and, therefore, that the closed state should be initiated. In the present embodiment, the indicator element 35 preferably comprises a control fragment 62 that releases the actuating element 36 to detect the closed state that causes the current nebulizer 1 or container 3 to close so that it cannot be used again. Preferably, the control element 62 comprises a cutout or cavity that enables or initiates movement of the locking element 61 to a locked position. Preferably, the locking element 61 locks or closes the insert opening 54 in the locked position, i.e., in the closed state. Preferably, the control element 62 is a wall or edge on the inside of the rotating indicating element 35. Preferably, the locking piece 61 is integrated into the indicating device 25 or its housing 31. The locking piece 61 can be moved, preferably, transversely or perpendicularly to the longitudinal or exit direction of the container or nebulizer and / or to the downward movement direction of the container 3. Preferably, the locking piece 61 blocks the drive or insertion movement of the drive piece 52, in particular with respect to the indicating device 25 and / or the (sufficient) insertion of the drive piece 52. Preferably, the locking piece 61 can be moved linearly and / or forms a sliding carriage. However, other construction solutions are also possible. Preferably, the locking piece 61 is moved into its locking position, in the present embodiment, preferably by means of the actuating spring 47 or any other suitable means of movement. Preferably, the locking piece 61 closes or blocks the insertion opening 54 of the indicating device 25 after the last dose of fluid 2 has been administered and when the closing state has been initiated or detected. This detection is preferably achieved by the locking piece 6f or any associated component, such as the control piece 63, allowing the control fragment 62 to pass through in the closed state, most preferably by spring force, in particular by the force of the drive spring 47 or similar, as shown schematically in Figure 11. Preferably, the locking piece 61 is connected to or constituted by the actuating element 36, or vice versa. Most preferably, the locking piece 61 forms a wall or side, preferably a flat side, of the actuating element 36. However, other construction solutions are also possible. In the present embodiment, the drive element 36 can be moved in the closed state from the first position to the third position, i.e., preferably in the opposite direction to the movement towards the second position. In the present embodiment, the actuating element 36 can close the insertion opening ML / a / ZUZZ / UUDUI or 54, preferably fully, in the third position (locking position). In other words, the locking position of the locking piece 61 preferably corresponds to the third position of the actuating element 36. In the closed state or in the third position, the drive element 36 moves with the drive arm 38 or its fragment 39 additionally in the drive direction, so that the drive fragment 39 passes the previous tooth 43 in the direction of rotation of the gear 41 as shown in Figure 15. Preferably, the actuating element 36 is constructed to prevent further use of the container 3 in the closed state or in the third position (locked position). Preferably, the actuating element 36 can be moved forward and backward between the first and second positions to adjust the indicating element 35 and can be moved to the third position to prevent further use of the container 3 in the closed state. In particular, the closed indicator device 25 or locking piece 61 causes, in particular, the container 3 to not be able to be moved inside the closed housing of the nebulizer 1 in a downward manner as described above and as required for normal or additional use, thus preventing normal use. In particular, the closing of the indicating device 25 or the insertion opening 54 causes the nebulizer 1 or the housing piece 18 to open at least partially when the nebulizer 1 is re-tensioned or partially tensioned. Figure 16 shows this state (nebulizer 1 partially tensioned with housing piece 18 partially open) in a schematic longitudinal section of the nebulizer 1. During the tensioning process, the container 3 moves downwards along with the indicating device 25. From the untensioned state (upper position of the container 3), the indicating device 25 is quickly engaged with its locking piece 61 / actuating element 36 by the member that generally actuates the indicating device 25, in this case, the drive piece 52, so that no further downward movement is possible. In particular, the locking piece 61 limits the axial movement of the container 3 in the nebulizer 1 in the closed state, preferably by preventing the insertion of the drive piece 52 into the indicating device 25 or by limiting its insertion in the closed state. Due to the force applied when the nebulizer 1 is tensioned and due to the resulting axial force during the movement of the container 3, the housing piece 18 will move outwards or relative to the nebulizer 1, the inner part 17, or the upper part 16 together with the container 3 and the indicating device 25 during the additional tensioning movement in the axial direction in the closed state. The previous downward movement of the container 3, the indicating device 25, and the housing piece 18 are possible due to a respectively constructed clamping of the housing piece 18 in the nebulizer 1. In particular, the holding force is selected or set so that it can be overcome by the downward movement of the container 3. In the present embodiment, the retaining element 19 engages with a retaining peak 64 in a respective retaining cavity 65 in the housing piece 18, or vice versa. Therefore, a substantially angled cut or slit can be made. However, the splice flanges, which extend at least essentially radially from the peak 64 on one side and the cavity 65 on the other, are slightly inclined, preferably from approximately 1° to 5° towards the radial plane, so that the axial force of the tensioning process can overcome the retaining force provided by the engagement of the peak 64 in the cavity 65, causing the retaining element 19 to flex radially and overcome the retaining engagement. Consequently, the housing piece 18 also moves downwards and is thus at least partially pushed away from the nebulizer 1, or separated from the upper part of the housing 16, and / or pushed away from the inner part 17. This axial or thrust displacement of the housing part 18 or any other opening of the nebulizer 1 preferably causes the nebulizer 1 to lock by means of the locking device 26 to prevent its reuse. Therefore, the indicating device 25 or its locking part 61 indirectly effect the desired closure of the nebulizer 1 in the closed state by means of the opening of the nebulizer 1. In the preferred mode, the locking device 26 prevents the tensioning of the nebulizer 1 in the closed state. Preferably, the locking device 26 comprises a movable locking element 66 and an associated locking spring 67. The locking element 66 is preferably axially movable between a locked position and an unlocked position. The locking element 66 is preferably moved to the locked position by the locking spring 67. In the closed position, the closing element 66 is preferably in its lower axial position shown in Figure 16. Figure 17 shows an enlargement of the part of Figure 16 marked with a circle. In the closed position, the locking element 66 blocks the rotation of the inner part 17 relative to the outer part 16 and thus (additionally) prevents the tensioning of the nebulizer 1. Preferably, this is achieved in the present embodiment by the locking element 66 moving or coupling, preferably axially, to a respective pocket 68 formed in the upper part 16, thereby blocking relative rotation. In particular, the locking element 66 engages with a coupling fragment 69 in the respective cavity or pocket 68, thus preventing any additional and / or reverse rotation. However, other design solutions are also possible. The locking device 26, in particular the locking element 66 and the locking spring 67, are arranged and / or supported, preferably, by the inner part 17 and / or extend between the inner part 17 and the upper part 16. The nebulizer 1, the inner part 17 or the locking device 26 preferably comprise a cover 70 that covers the locking device 26 at least on the periphery of the lower part 17b of the inner part 17 to prevent or at least hinder any unwanted manipulation of the locking device 26 or locking element 66 by the user or patient. Figure 18 shows the nebulizer 1 in a schematic cross-section similar to Figure 16, but with the locking device 26 in the unlocked position, i.e., the locking element 66 in the upper position. The locking device 26 or the locking element 66 is preferably placed in this position or unlocked only by closing the nebulizer 1, in particular, with the housing part 18 in the fully engaged or closed position. In the described embodiment, the housing part 18 preferably comprises an axially and / or finger-shaped actuator 71 that extends to the locking device 66 and / or into the cover 70 and / or is axially spliced ​​and / or pushes the locking element 66 into its unlocked position (upper position), as shown in Figure 18. Therefore, only the fully closed nebulizer 1 or housing part 18 unlocks the locking device 26 and thus unlocks the nebulizer 1. The actuator 71 is preferably arranged inside the housing piece 18, so that any type of manipulation is not possible or at least made difficult. When nebulizer 1 is in the closed position, and preferably when nebulizer 1 or its housing part 18 is partially opened by the final tensioning process, nebulizer 1 cannot be used again with the container 3 and the indicator device 25 in their closed position. The locking device 26 locks, preferably automatically. Preferably, the locking spring 67 moves the locking element 66 to the closed position, so that during at least partial opening of nebulizer 1 or axial displacement of its housing part 18, the locking device 26 or its locking element 66 can be moved and do move to the closed position. Preferably, the closing element 66 can be moved (essentially or solely) in an axial direction. After replacing the existing container 3 with its locked indicator device 25 (locking piece 61 in the locked position) with a new container 3 that includes a new or reset indicator device 25, the nebulizer 1 or its housing piece 18 can be fully closed again. Therefore, the nebulizer 1 or its locking device 26 can be unlocked or is unlocked again. Preferably, the actuator 71 pushes the locking element 66 back into its unlocked position. Therefore, the locking device 26 is reset or unlocked again, preferably by (completely) closing the nebulizer 1, its housing 24 or its housing part 18, and the nebulizer 1 can be used with the new container 3 as described above. It should be noted that the insertion opening 54, which is preferably arranged centrally and / or opens axially and / or allows the axial insertion of a drive element, in particular the drive piece 52, in the present embodiment, can also be formed as a cavity, groove, slit or the like and / or can be arranged in any position or location in the indicating device 25 with any orientation. Alternatively, the insertion opening 54 or its closure can also be omitted. Conversely, the indicating device 25, the actuating element 36, or the locking piece 61 can communicate more or less directly with or actuate the closing device 26, or, for example, the retaining element 19 or the locking element 8, in order to cause a direct or indirect closure of the nebulizer 1 or the container 3 to prevent their reuse. Figure 19 shows a schematic cross-section of the indicating device 25 according to a modified embodiment of the present invention. Figure 20 shows a perspective view of the cross-section according to Figure 19. The following describes only the relevant differences, so that the explanations and aspects above apply additionally, in particular, in the same or similar way, without repetition. In the modified embodiment, the drive arm 38 and the drive fragment 39 are not engaged in the worm gear drive, i.e., between the gear 41 and the engagement projections 60 of the drive element, namely the indicator element 35, but rather engage with or drive the gear 41 on the opposite side of the worm gear drive, preferably from below rather than from above, as shown in Figure 19. Specifically, the drive arm 38 extends approximately in a radial plane and / or in a common plane with the drive spring 47 and / or the locking element 61 or the sliding carriage element 36. Preferably, the drive arm 38 or the drive fragment 39 are coupled with the gear 41 on the opposite side to the container 3 or the clamping area 32. In the modified embodiment, the indicating device 25 performs the count, preferably, when the nebulizer 1 is tensioned, i.e., during the tensioning process and not during the administration process as provided in the first embodiment of the present invention. In particular, the drive element 36 or its arm 38 drives or rotates the transmission 40 or the gear 41 when the drive piece 52 is inserted into the indicating device 25, its housing 31, or its insertion opening 54, and / or when the drive element 36 moves from the first position to the second position, and / or when the drive piece 52 pushes the drive element 36 transversely. In the opposite direction, the drive arm or its drive segment 39 passes to the next tooth 43 of the gear 41; that is, it does not drive the gear 41. In the modified mode, the indicating device 25 or the count is not driven by the force of the drive spring 47 or any other spring or energy storage, but by the relative movement of the indicating device 25 within the nebulizer 1 or by the insertion of a drive element, such as the drive piece 52. However, other construction solutions are also possible. In the modified mode, the carriage / drive element 36 / locking piece 61 locks to move to the third position or the closed position, releasing during tensioning when a predetermined number of administrations is reached or exceeded. The carriage / drive element 36 / locking piece 61 then engages with the drive piece 52 as the count is performed during tensioning. When nebulizer 1 is actuated or when locking element 8 is pressed, nebulizer 1 fires and the (final) dose of fluid 2 is nebulized. During this nebulization, the drive piece 52 is withdrawn from the indicator device 25 or the insertion opening 54, allowing the carriage / drive element 36 / locking piece 61 to move freely to the third position or the closed position due to the force of the drive spring 47 or any other spring-driven means. During the next tensioning, the nebulizer 1 or its housing 24 or its housing part 18 will partially open when the drive piece 52 is spliced ​​to the closed indicating device 25, in particular to the carriage / drive element 36 / locking piece 61, which limits or closes the insertion opening 54. In the previous mode, the counting or activation of the indicator device 25 occurs when the fluid is administered, i.e., when the drive piece 52 is withdrawn from the insertion opening 54. There, the carriage / drive element 36 / locking piece 61 is released during the last use of the nebulizer 1 or the administration, i.e., when it is moved from the second to the first position, so that the carriage / drive element 36 / locking piece 61 can then be moved directly to the third position or to the unlocked position. Therefore, further administration is not possible. In both cases, i.e., in the previous mode and in the modified mode, the indicator device 25 blocks the complete axial or downward mobility of the container 3 within the nebulizer 1 in the closed state and / or causes at least partially the opening of the nebulizer housing 24 and / or the housing part 18 in the closed state, in particular, when the nebulizer 1 is at least partially tightened for the last time with the current container 3. Furthermore, at least partial opening of the nebulizer 1 or its housing 24 or its housing part 18 causes the nebulizer 1 to lock up, in particular, preventing it from being tightened further or from being used with the current container 3. Figures 19 and 20 show the indicator device 26, according to the present invention, in the initial or unactuated state and / or with the actuating element 36 in the first position. The control piece 63, which extends preferably upwards and / or axially, is joined to the control piece 62, preferably in the form of a ring, which is preferably formed by or within the indicator element 35. Preferably, the control piece 62 has a radial distance from the outer wall of the indicator element 35, such that the control piece 63 can move in the middle and the actuating element 36 can move freely between the first and second positions, while the connection of the control piece 63 to the control piece 62 prevents the actuating element 36 from moving from the first position further towards the third position and / or furthermore, to (completely) close the insertion opening 54. Preferably, the protrusions 60 are notched and / or tapered at their free ends. Preferably, the protrusions 60 are molded into or connected to the control piece 62. In general, the insertion opening 54 is preferably provided with a tapered surface or edge to facilitate the insertion of the drive piece 52 or similar. Preferably, the support structure 55 forms or comprises one or more flexible arms for movably supporting the piercing piece 48, preferably in the center of the indicating device 25 or its housing 31 or a respective opening in the housing 31, such that the piercing piece 48 is generally held within the indicating device 25 but can be moved and, in particular, protrude outwards and / or towards the container 3 to open or pierce the ventilation means. However, other construction solutions are possible. In general, the indicator device 25 and the container 3 form an inseparable assembly or unit, which must be completely replaced after use, particularly after reaching the closed state. However, it is also possible that the container 3 and the indicator device 25 may be supplied as a kit that the user or patient can assemble. In general, the indicator device 25 cannot be reset after reaching the closed state, so it cannot be reused. However, it is also possible to modify the indicator device 25 so that it can be reset and reused. In this case, the indicator device 25 must be detached from the existing container 3 and connected to a new (unused) container 3. Ideally, changing the container will automatically reset the indicator device 25. In general, the drive element 36 or the locking piece 61 can be moved, preferably linearly, in particular, as a sliding carriage. Specifically, a sliding carriage is formed. Preferably, the sliding carriage forms a base part of the drive element 36 or the locking part 61. Preferably, the sliding carriage, the drive element 36, or the locking piece 61 are held in a movable position by sliding guides 72 on opposite sides, preferably on opposite sides of the insertion opening 54, as shown schematically in Figures 8 and 9. Preferably, the guides 72 are formed by the respective or similar tracks of the housing 31 or its lower portion 34, which are clamped onto the respective edges or base fragments 73 of the drive element 36 or the locking piece 61 to form the desired sliding orientation. However, other construction solutions are also possible. Instead of the drive element 36, which can preferably be moved linearly or slidingly, and / or the locking piece 61, any other movement, in particular a radial and / or pivoting movement, is possible, in particular to partially or completely close the insertion opening 54. Alternatively, the actuating element 36 and / or the locking piece 61 can be moved outwards from the indicating device 25 or its housing 31, preferably transversely and / or on one side of the indicator housing 31 to lock at least one coupling possibility and / or actuate any other component in the closed state or to lock the nebulizer 1 and / or the container 3. Additionally or alternatively, the actuating element 36 and / or the locking piece 61 can be attached to or spliced ​​to an area or contour of the housing piece 18 and / or the nebulizer housing 24 or the like, to limit or prevent operation or movement in the closed state to prevent further use of the nebulizer 1 and / or the container 3 in the closed state. The actuating element 36 and / or the locking piece 61, in particular when actuated radially, is preferably moved by the spring 47 or any other spring-like means. The spring or the spring-like means may be formed entirely and / or from plastic parts or pieces. Alternatively, a spiral or clock spring or any other spring, such as the helical spring 47 or similar, may be used to move the actuating element 36 and / or the locking piece 61, preferably in the closed position. It is also possible for the drive piece 52 to directly drive or actuate the gear 41. In this case, the drive piece 52 is preferably supported elastically by the housing piece 18, in particular by a spring means (not shown), specifically to compensate for axial clearance and / or to allow radial or transverse bending of the drive piece 52. Alternatively, the drive piece 52 may be flexible to allow transverse bending so that it engages with the gear 41 in a single direction of axial movement relative to the gear 41 to rotate the gear 41 in a single direction of rotation. The indicating device 25 may comprise any other counting mechanism, in particular, as described in WO 2009 / 037085 A1, from page 4, line 19 to page 10, line 13, which is incorporated herein by reference. The counting mechanism may also initiate, release, or actuate the drive element 36 and / or the locking piece 61. When this counting mechanism is used, the rotating indicating element 35 may also release or control the release of the carriage, the drive element 36, or the locking piece 61 in the closed position to move to the third position or to the closed position, or to close the insertion opening 54. It is also possible for the carriage or locking piece 61 to be independent of the counting function. In particular, the drive piece 52 can actuate the core of the counting mechanism described in WO 2009 / 037085 A1 or similar, and / or drive or actuate the indicating device 25, or perform the counting function without actuating the carriage or locking piece 61. In this case, the functions are separate. The carriage and / or locking piece 61 are preferably used only to limit or close the insertion opening 54 in the closed position, but not to actuate or drive the indicating device 25 of its counting mechanism, or the transmission 40, or the indicating element 35, or similar components. The container 3 or the indicating device 25 or the insertion opening 54 may have an optional guard 74, shown schematically only in Figure 19, which covers, in particular, the insertion opening 54 before its first use. Preferably, the protection 74 should be removed before the container 3 and / or the indicator device 25 can be inserted into the nebulizer 1 or the housing piece 18. Preferably, the protection 74 extends transversely over the indicating device 25 or its housing 31 and / or over the container 3 and / or has a larger diameter than the indicating device 25 and / or the container 3, in particular so that it does not enter the nebulizer 1 or the housing piece 18. Preferably, protection 74 can only be removed irreversibly, meaning it cannot be reconnected once removed. Preferably, the guard 74 covers or closes the insertion opening 54 and / or the indicator device 25. Preferably, the protection 74 is connected to the indicating device 25 or to the container 3 by form fit or force fit and / or by pressure fit or clip fit. As mentioned above, the individual features, aspects and / or principles of the described modalities can also be combined with each other as desired, and can be used, in particular, in the nebulizers described 1, but also in similar or different nebulizers. The features of the different modalities can be combined or interchanged. Unlike standalone or similar equipment, the proposed nebulizer 1 is preferably designed to be portable and is, in particular, a manually operated mobile device. However, the proposed solution can be used not only in the nebulizers 1 specifically described herein, but also in other nebulizers or inhalers, for example, powder inhalers or so-called metered-dose inhalers. Preferably, fluid 2 is a liquid, as mentioned above, specifically an aqueous or ethanolic pharmaceutical formulation. However, it can also be any other pharmaceutical formulation, a suspension, or the like. According to an alternative embodiment, the fluid 2 may also comprise particles or powder. In this case, instead of the ejection nozzle 12, any other type of delivery device may be provided, in particular, an ejection opening (not shown) or a delivery channel (not shown) for supplying the fluid or powder, or the like, to the mouthpiece 13. The optional air supply opening 15 then serves to supply ambient air, preferably in parallel and generally to allow airflow with a volume sufficient for breathing or inhalation through the mouthpiece 13. If necessary, fluid 2 can also be atomized using a propellant gas. The preferred ingredients and / or formulations of the preferably medicinal fluid 2 are listed, in particular, in WO 2009 / 115200 A1, preferably on pages 25 to 40, or in EP 2 614 15 848 A1, paragraphs 0040 to 0087, which are incorporated herein by reference. In particular, these may be solutions, mixtures, aqueous or non-aqueous formulations, containing ethanol or free from any solvent, or the like. List of reference numbers 1 nebulizer 37 brand 2 fluid 38 drive arm 3 container 39 drive fragment 5 4 bag 40 transmission 5 pressure generator 41 gear 6 support 42 worm gear 7 drive spring 43 tooth 8 locking element 44 shaft areas 10 9 transport tube 45 support area 10 check valve 46 support fragment 11 pressure chamber 47 drive spring 12 nozzle 48 piercing piece 13 mouthpiece 49 piercing tip 15 14 aerosol 50 aluminum foil 15 air supply opening 51 slit 16 upper part of housing 52 drive piece 17 inner part 53 bottom 17a upper part of inner part 54 insertion opening 20 18 housing piece (lower part) 55 support structure 19 retaining element 56 flexible arm 20 vent spring 57 slot 21 container base 58 ratchet 22 piercing element 59 surface 25 23 vent hole 60 protrusions 24 nebulizer housing 61 locking piece25 indicating device 62 control fragment 26 locking device 63 control piece 27 mouthpiece cap 64 retaining spike 30 28 stop 65 retaining cavity 29 container housing 66 locking element 30 container rim 67 locking spring 31 indicator housing 68 pocket 31a visor 69 coupling fragment 35 32 clamping area 70 cover 33 top part 71 actuator 34 bottom part 72 sliding guide 35 indicating element 73 base piece 36 actuating element 74 guard

Claims

1. An indicating device (25) for a container (3) containing a fluid (2) to be nebulized by a nebulizer (1), the indicating device (25) being adapted to count and / or indicate a number of administrations made or still available with the container (3) or nebulizer (1), characterized in that the indicating device (25) comprises a housing (31) with an insertion opening (54) for a drive piece (52) for driving, actuating or initiating the counting or indication of the indicating device (25), wherein the indicating device (25) is adapted to block or close the insertion opening (54) in a closed state when a predetermined number of administrations is reached or exceeded.

2. The indicator device according to claim 1, further characterized in that the insertion opening (54) allows the insertion of the drive piece (52) of the nebulizer (1) when the insertion opening (54) is not blocked or closed.

3. The indicating device according to claim 1 or 2, further characterized in that the insertion opening (54) is adapted to receive the drive piece (52) in the unlocked state of the nebulizer (1), so that after a relative movement between the indicator housing (31) and a housing (24) of the nebulizer (1), the drive piece (52) actuates the indicating device (25).

4. The indicating device in accordance with any of the preceding claims, further characterized in that the insertion opening (54) is arranged in a housing (31) or a lower part (34) of the indicating device (25).

5. The indicating device in accordance with any of the preceding claims, further characterized in that the insertion opening (54) is arranged in the center and / or on an axial side of the indicating device (25).

6. The indicating device in accordance with any of the preceding claims, further characterized in that the indicating device (25) comprises an indicating element (35) and an actuating element (36) for graduating the indicating element (35).

7. The conformity indicator device according to claim 6, further characterized in that the actuating element (36) is constructed to block or close the insertion opening (54) in the closed state.

8. The conformity indicator device according to claim 6 or 7, further characterized in that the actuating element (36) is adapted to be actuated by the drive piece (52).

9. The indicating device in accordance with any of the preceding claims, further characterized in that the indicating device (25) comprises a locking piece (61) that locks or closes the insertion opening (54) in the closed state.

10. A container (3) for a nebulizer (1), the container (3) containing a fluid (2), and the container (3) is characterized in that it comprises an indicating device (25) for counting and / or indicating a quantity of administrations made or still available with the container (3), wherein the indicating device (25) is constructed as claimed in any of the preceding claims.

11. The container according to claim 10, further characterized in that the indicator device (25) comprises a locking piece (61) adapted to lock the container (3) in the closed state, wherein the locking piece (61) closes the insertion opening (54) of the indicator device (25) in the closed state.

12. The container according to claim 11, further characterized in that the locking piece (61) is integrated into a housing (31) of the indicating device (25) and / or can be moved transversely to a longitudinal or supply direction of the container (3).

13. The container according to claim 11 or 12, further characterized in that the locking piece (61) is connected to or forms an actuating arm (38) for graduating the indicating element (35).

14. The container according to any of claims 11 to 13, further characterized in that the locking piece (61) comprises or is formed by means of a sliding carriage.

15. A nebulizer (1) for a fluid (2), the nebulizer (1) being characterized in that it comprises: a replaceable container (3) containing the fluid (2); a nebulizer housing (24) for receiving the container (3); a housing piece (18) that can be separated from the nebulizer housing (24) or opened to replace the container (3); and an indicating device (25) for counting and / or indicating a number of administrations made or still available in the container (3); wherein the indicating device (25) is constructed as claimed in any one of claims 1 to 9 or wherein the container (3) is constructed as claimed in any one of claims 10 to 14.

16. The nebulizer according to claim 15, further characterized in that the indicator device (25) can be moved axially or back and forth together with the container (3) inside the nebulizer (1), preferably during the supply or nebulization of the fluid (2) and / or the tensioning of the nebulizer (1).

17. The nebulizer according to claim 15 or 16, further characterized in that the indicator device (25) comprises a locking piece (61) to prevent use of the container (3) in the closed state, wherein the locking piece (61) is adapted to close the insertion opening (54) of the indicator device (25) in the closed state.

18. The nebulizer according to claim 17, further characterized in that the locking piece (61) is integrated into the housing (31) of the indicating device (25) and / or can be moved transversely to a longitudinal or supply direction of the container (3) or nebulizer (1).

19. The nebulizer according to claim 17 or 18, further characterized in that the locking piece (61) is connected to or forms an actuating arm (38) for adjusting an indicator element (35) of the indicating device (25).

20. The nebulizer according to any of claims 17 to 19, further characterized in that the locking piece (61) comprises or is formed by means of a sliding carriage.

21. The nebulizer according to any of claims 17 to 20, further characterized in that the insertion opening (54) allows the insertion of the drive piece (52) of the nebulizer (1) when the insertion opening (54) is not blocked or closed.

22. The nebulizer according to any of claims 17 to 21, further characterized in that the nebulizer (1) comprises the drive piece (52) for driving or actuating or starting the indicator device (25).

23. The nebulizer according to claim 22, further characterized in that the drive piece (52) is adapted to enter or engage through the insertion opening (54) of the indicator device (25) or its housing (31) when it tensions the nebulizer (1) and / or moves the indicator device (25) downwards.

24. The nebulizer according to claim 22 or 23, further characterized in that the indicating device (25) comprises an indicating element (35) and an actuating element (36) for adjusting the indicating element (35), wherein the drive piece (52) is adapted to actuate the actuating element (36).

25. The nebulizer according to any of claims 15 to 24, further characterized in that the indicator device (25) is inseparably connected to the container (3), but can be separated from the nebulizer housing (24) and the housing piece (18), so that it can be replaced together with the container (3).

26. The nebulizer according to any of claims 15 to 25, further characterized in that the indicator device (25) is adapted to cause at least partial opening of the nebulizer housing (24) and the housing piece (18) in the closed state when the nebulizer (1) is at least partially tensioned for the last time with the current container (3).

27. The nebulizer according to any of claims 15 to 26, further characterized in that the indicator device (25) is adapted to prevent the complete closure assembly of the nebulizer housing (24), the housing piece (18) and the container (3) in the closed state.

28. The nebulizer according to any of claims 15 to 27, further characterized in that the indicator device (25) is adapted to block the complete insertion of the container (3) into the nebulizer (1) and / or the housing piece (18) or to block the complete axial or downward movement of the container (3) in the nebulizer (1) in the closed state.

29. The nebulizer according to any of claims 15 to 28, further characterized in that the nebulizer (1) is adapted to block use or tensioning if the nebulizer housing (24) or housing part (18) is at least partially open.

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