NOVEL INSECT-INHIBITING PROTEINS

Abstract

The present invention relates to a recombinant nucleic acid molecule characterized in that it comprises a heterologous promoter operatively linked to a polynucleotide segment encoding a pesticide protein or a pesticide fragment thereof, wherein: a) the pesticide protein comprises the amino acid sequence of SEQ ID NO: 61, or SEQ ID NO: 83; b) the pesticide protein comprises an amino acid sequence having at least 99% identity with respect to SEQ ID NO: 61, or SEQ ID NO: 83.

Description

The present application claims the benefit of US Provisional Application No. 62 / 480,614, filed April 3, 2017, which is incorporated herein in its entirety by this reference. Adding Sequence Listing On April 2, 2018, the file named “MONS443WO-sequence_listing.txt” was created, with an electronic sequence listing. This file is 653 kilobytes (measured on MS-Windows®) and is filed simultaneously electronically (using the United States Patent Office's EFS-Web filing system) and is incorporated into this application in its entirety. through this reference. TECHNICAL FIELD The invention relates, in general terms, to the field of insect inhibitory proteins. A novel class of proteins exhibiting insect inhibitory activity against agriculturally relevant pests of crop plants and seeds is described. In particular, the proteins described are active at the insecticidal level against pests relevant in the agriculture of crop plants and seeds, in particular the insect species of Coleoptera and Lepidoptera. Plants, plant parts and seeds are provided with a recombinant polynucleotide construct encoding one or more of the described toxin proteins. BACKGROUND OF THE INVENTION Improving the yield of agriculturally relevant plant crops, including corn, soybeans, sugarcane, rice, wheat, vegetables, and cotton, among others, has gained great importance. In addition to the growing need to grow agricultural products for food, clothing and energy supply for a growing human population, climate-related effects and pressure from a growing population to use land for purposes other than agriculture reduce the amount of arable land for agriculture. These factors have led to discouraging food security forecasts, particularly without major improvements in agronomic and plant biotechnology practices. In light of these pressures, ecologically sustainable improvements in technology, agricultural techniques and pest control are vital tools for expanding crop production on the limited amount of arable land available for agriculture. Insects, particularly insects from the orders Lepidoptera and Coleoptera, are considered a major cause of crop damage, thereby decreasing crop yields in infested areas. Historically, intensive application has been used CQCLLn / LZnZ / E / Yli of synthetic chemical insecticides as a pest control agent in agriculture. Concerns for the environment and human health, in addition to problems that have arisen regarding resistance, have stimulated research and development of biological pesticides. These investigations led to the progressive discovery and use of various entomopathogenic microbial species, including bacteria. The biological control paradigm changed with the discovery and development of the potential of entomopathogenic bacteria, especially bacteria of the genus Bacillus, as a biological pest control agent. Strains of the Bacillus thuringiensis (Bt) bacteria have been used as a source of pesticide proteins since it was discovered that strains have high toxicity against specific insects. Bt strains are known to produce delta endotoxins found in parasporal inclusion crystal bodies at the onset of sporulation and during the static growth phase (e.g., Cry proteins) and are also known to produce an insecticidal protein secreted. Upon ingestion by a susceptible insect, delta endotoxins and secreted toxins produce their effects on the surface of the midgut epithelium, destroying the cell membrane and leading to cell destruction and death. Genes encoding insecticidal proteins have also been identified in bacterial species other than Bt, including other Bacillus and several additional bacterial species, such as Brevibacillus laterosporus, LysínibaciHus sphaericus ("Ls", formerly known as Bacillus sphaericus), and PaenibaciiiuspopiHiae. Secreted and crystalline soluble insecticidal toxins are highly specific to their hosts and have gained global acceptance as alternatives to chemical insecticides. For example, insecticidal toxin proteins have been used in various agricultural applications to protect agriculturally important plants from insect infestations, decrease the need for chemical pesticide applications, and increase yields. Insecticidal toxin proteins are used to control agriculturally relevant pests of crop plants with mechanical methods, such as spraying to disperse microbial formulations with various bacterial strains on plant surfaces, as well as with genetic transformation techniques to produce transgenic seeds and plants that express insecticidal toxin protein. The use of transgenic plants with expression of insecticidal toxin proteins has been adapted worldwide. For example, in 2012, 26.1 million hectares of transgenic crops expressing Bt toxins were planted (James, C., Global Status of Commercialized Biotech / GM Crops: 2012. ISAAA report no. 44). The global use of transgenic insect-protected crops and the limited amount of insecticidal toxin proteins used in these crops has created a selection pressure for existing insect alleles that impart resistance to currently used insecticidal proteins. The development of resistance in target pests to insecticidal toxin proteins creates the CQCLLn / LZnZ / E / Yli continued need to find and develop new forms of insecticidal toxin proteins that are useful in controlling the increase in resistance in insects to transgenic crops with expression of insecticidal toxin proteins. New protein toxins with better efficacy and control over a broader spectrum of susceptible insect species will reduce the number of surviving insects that can develop resistance alleles. Likewise, the use in a plant of two or more transgenic insecticidal toxin proteins toxic to the same insect pest and exhibiting different modes of action reduces the likelihood of resistance in any individual target insect species. Therefore, the inventors herein describe a family of novel protein toxins from Bacillus taterosporous, together with similar toxin proteins, variant proteins and examples of recombinant proteins that exhibit insecticidal activity against target lepidopterans and coleopterans, in particular against the corn chrysomelid. western and northern corn chrysomelid. BRIEF DESCRIPTION OF THE INVENTION Described herein is a group of novel pesticidal proteins with insect inhibitory activity (toxin proteins), referred to herein as TIC7040-related protein toxins, which demonstrate inhibitory activity against one or more crop plant pests. The TIC7040 protein and proteins in the TIC7040 protein toxin class can be used alone or in combination with other insecticidal proteins and toxic agents in formulations and in planta, providing alternatives to the insecticidal proteins and insecticidal chemicals currently used in agricultural systems. In one embodiment, the present application describes a recombinant nucleic acid molecule comprising a heterologous promoter operably linked to a polynucleotide segment encoding a protein or a pesticidal fragment thereof, wherein: (a) said protein pesticide comprises the amino acid sequence of SEC. ID. No. 2, SEC. ID. No. 4, SEC. ID. No. 6, SEC. ID. No. 8, SEC. ID. No. 10, SEC. ID. No. 12, SEC. ID. No. 14, SEC. ID. No. 16, SEC. ID. No. 18, SEC. ID. No. 20, SEC. ID. No. 22, SEC. ID. No. 24, SEC. ID. No. 26, SEC. ID. No. 28, SEC. ID. No. 30, SEC. ID. No. 32, SEC. ID. No. 34, SEC. ID. No. 43, SEC. ID. No. 46, SEC. ID. No. 48, SEQ ID. No. 50, SEC. ID. No. 53, SEC. ID. No. 55, SEC. ID. No. 57, SEC. ID. No. 59, SEC. ID. No. 61, SEQ ID. No. 63, SEC. ID. No. 65, SEC. ID. No. 67, SEC. ID. No. 69, SEC. ID. No. 71, SEC. ID. No. 73, SEQ ID. No. 75, SEC. ID. No. 77, SEC. ID. No. 79, SEC. ID. No. 81, SEC. ID. No. 83, SEC. ID. No. 85, SEQ.ID. No. 87, SEC. ID. No. 89, SEC. ID. No. 91, SEC. ID. No. 93, SEC. ID. No. 95, SEC. ID. No. 97, SEQ.ID. No. 99, SEC. ID. No. 101, SEC. ID. No. 103, SEC. ID. No. 105, SEC. ID. No. 107, SEC. ID. #109, SEC. ID. No. 111, SEC. ID. No. 113, SEC. ID. No. 115, SEC. ID. No. 117, SEC. ID. No. 119, SEQ ID. No. 121, SEC. ID. No. 123, SEC. ID. No. 125 or SEC. ID. #127; or (b) said pesticidal protein PQCLLn / LZnZ / E / Yli comprises an amino acid sequence with: (i) at least 75% identity with respect to SEC. ID. No. 18, SEC. ID. No. 20, SEC. ID. No. 22, SEC. ID. No. 24, SEC. ID. No. 26, SEC. ID. #28, SEC. ID. No. 63, SEC. ID. No. 65, SEC. ID. No. 67, SEC. ID. No. 69, SEC. ID. No. 75, SEC. ID. #85, SEC. ID. No. 87, SEC. ID. No. 89, SEC. ID. No. 91, SEC. ID. No. 93, SEC. ID. No. 95, SEC. ID. #97, SEC. ID. No. 99, SEC. ID. No. 101, SEC. ID. No. 103, SEC. ID. No. 105, SEC. ID. No. 107 or SEQ ID. #109; or (ii) at least 80% with respect to the SEC. ID NO. 111, SEC. ID NO. 113, SEC. ID. No. 115, SEC. ID. No. 119, SEC. ID. No. 125 or SEC. ID. #127; or (i¡) at least 85% identity with respect to the SEC. ID. No. 121 or SEC. ID. #123; or (iv) at least 90% identity with respect to the SEC. ID. No. 2, SEC. ID. No. 4, SEC. ID. No. 6, SEC. ID. No. 8, SEC. ID. No. 10, SEC. ID. No. 14, SEC. ID. No. 34, SEC. ID. No. 43, SEC. ID. No. 46, SEC. ID. No. 48, SEC. ID. No. 50, SEC. ID. No. 57, SEC. ID. No. 71, SEC. ID. No. 73, SEC. ID. No. 77, SEC. ID. No. 79, SEQ NO:81 or SEC. ID. #117; or (v) at least 93% identity with respect to the SEC. ID. No. 12, SEC. ID. No. 16, SEC. ID. No. 30 and SEC. ID. #59; or (vi) at least 94% identity with respect to the SEC. ID. No. 53 and SEC. ID. #55; or (vii) at least 99% identity with respect to the SEC. ID. No. 32, SEC. ID. No. 61 or SEC. ID. #83; or (c) said polynucleotide segment is hybridized with a polynucleotide with the nucleotide sequence of SEQ. ID. No. 1, SEC. ID. No. 3, SEC. ID. No. 5, SEC. ID. No. 7, SEC. ID. No. 9, SEC. ID. No. 11, SEC. ID. No. 13, SEC. ID. No. 15, SEC. ID. No. 17, SEC. ID. No. 19, SEC. ID. No. 21, SEC. ID. No. 23, SEC. ID. No. 25, SEC. ID. No. 27, SEC. ID. No. 29, SEC. ID. No. 31, SEC. ID. No. 33, SEC. ID. No. 35, SEC. ID. No. 36, SEC. ID. No. 37, SEC. ID. No. 38, SEC. ID. No. 39, SEC. ID. No. 40, SEC. ID. No. 41, SEC. ID. No. 42, SEC. ID. No. 44, SEC. ID. No. 45, SEC. ID. No. 47, SEC. ID. No. 49, SEC. ID. No. 51, SEC. ID. No. 52, SEC. ID. No. 54, SEC. ID. No. 56, SEC. ID. No. 58, SEC. ID. No. 60, SEC. ID. No. 62, SEC. ID. No. 64, SEC. ID. No. 66, SEC. ID. No. 68, SEC. ID. No. 70, SEC. ID. No. 72, SEC. ID. No. 74, SEC. ID. No. 76, SEC. ID. No. 78, SEC. ID. No. 80, SEC. ID. No. 82, SEC. ID. No. 84, SEC. ID. No. 86, SEC. ID. No. 88, SEC. ID. No. 90, SEC. ID. No. 92, SEC. ID. No. 94, SEC. ID. No. 96, SEC. ID. No. 98, SEC. ID. No. 100, SEC. ID. No. 102, SEC. ID. No. 104, SEC. ID. No. 106, SEC. ID. No. 108, SEC. ID. No. 110, SEC. ID. No. 112, SEC. ID. No. 114, SEC. ID. No. 116, SEC. ID. No. 118, SEC. ID. No. 120, SEC. ID. No. 122, SEC. ID. No. 124 or SEC. ID. #126; or (d) said recombinant nucleic acid molecule is operably linked to a vector and said vector is selected from the group consisting of a plasmid, phagemid, bacmid, cosmid and a yeast or bacterial artificial chromosome. The recombinant nucleic acid molecule may comprise a sequence that expresses the pesticidal protein in a plant or is expressed in a plant cell to produce an amount of pesticidal protein effective as a pesticide. In another embodiment of this application are host cells comprising a recombinant nucleic acid molecule of the application, wherein the host cell is selected from the group consisting of a plant and a bacterial cell. host cells CQCLLn / LZnZ / E / Yli include Agrobacterium, Rhizobium, Bacillus, BrevibaciHus, Escherichia, Pseudomonas, Klebsiella, Pantoeay Erwinia. In certain embodiments, said species Bacillus is Bacillus cereus or Bacillus thuringiensis, where said BrevibaciHus is BrevibaciHus iaterosperus or said Escheríchia is Escheríchia coii. Contemplated plant host cells include a dicot cell and a monocot cell. Other contemplated plant host cells include alfalfa, banana, barley, bean, broccoli, cabbage, Brassica, carrot, tapioca, castor, cauliflower, celery, chickpea, bok choy, citrus plant, coconut, coffee, corn, clover, cotton (Gossypium sp.), a cucurbit, cucumber, Douglas fir, eggplant, eucalyptus, flax, garlic, grapes, hops, leek, lettuce, bronco pine, millet, melons, walnut, oats, olive, onion, ornamental plants, palm tree, pasture grass, pea, peanut, pepper, pigeonpea, pine, potato, poplar, pumpkin, pine consigne, radish, rapeseed, rice, roots, rye, safflower, bush, sorghum, southern pine, soybean, spinach , pumpkin, strawberry, sugar beet, sugar cane, sunflower, sweet corn, American storax, sweet potato, meadow grass, tea, tobacco, tomato, triticale, grass grass, watermelon and wheat. In yet another embodiment, the pesticide protein exhibits activity against a coleopteran insect, including western corn chrysomelid, southern corn chrysomelid, northern corn chrysomelid, Mexican corn chrysomelid, Brazilian corn chrysomelid, doryphora, Brazilian corn chrysomelid with Diabrotica viríduia and Diabrotica speciosa, aphid beetle, cruciferous banded flea and jumping flea. In another embodiment, the pesticidal protein exhibits activity against a lepidopteran insect, including black cutworm, corn earworm, diamondback moth, European screwworm, armyworm, bollworm, soybean looper, corn borer. southwestern corn, tobacco budworm, legume caterpillar, sugarcane leafworm, lesser borer, African bollworm, beet beetle, cabbage caterpillar, defoliator or pink cotton bollworm. Also contemplated in the present application are plants comprising a recombinant nucleic acid molecule comprising a heterologous promoter operably linked to a polynucleotide segment encoding a protein or a pesticidal fragment thereof, wherein: (a) said protein pesticide comprises the amino acid sequence of SEQ. ID. No. 2, SEC. ID. No. 4, SEC. ID. No. 6, SEC. ID. No. 8, SEC. ID. No. 10, SEC. ID. No. 12, SEC. ID. No. 14, SEC. ID. No. 16, SEC. ID. No. 18, SEC. ID. No. 20, SEC. ID. No. 22, SEC. ID. No. 24, SEC. ID. No. 26, SEC. ID. No. 28, SEC. ID. No. 30, SEC. ID. No. 32, SEC. ID. No. 34, SEC. ID. No. 43, SEC. ID. No. 46, SEQ ID. No. 48, SEC. ID. No. 50, SEC. ID. No. 53, SEC. ID. No. 55, SEC. ID. No. 57, SEC. ID. No. 59, SEQ ID. No. 61, SEC. ID. No. 63, SEC. ID. No. 65, SEC. ID. No. 67, SEC. ID. No. 69, SEC. ID. No. 71, SEQ ID. No. 73, SEC. ID. No. 75, SEC. ID. No. 77, SEC. ID. No. 79, SEC. ID. No. 81, SEC. ID. No. 83, SEQ ID. No. 85, SEC. ID. No. 87, SEC. ID. No. 89, SEC. ID. No. 91, SEC. ID. No. 93, SEC. ID. No. 95, SEQ ID. CQCLLn / LZnZ / E / Yli η.° 97, SEC. ID. No. 99, SEC. ID. No. 101, SEC. ID. No. 103, SEC. ID. No. 105, SEC. ID. No. 107, SEC. ID. No. 109, SEC. ID. No. 111, SEC. ID. No. 113, SEC. ID. No. 115, SEC. ID. No. 117, SEC. ID. No. 119, SEC. ID. No. 121, SEC. ID. No. 123, SEC. ID. No. 125 or SEC. ID. #127; or (b) said pesticidal protein comprises an amino acid sequence with: (i) at least 75% identity to SEQ. ID. No. 18, SEC. ID. No. 20, SEC. ID. No. 22, SEC. ID. No. 24, SEC. ID. #26, SEC. ID. No. 28, SEC. ID. No. 63, SEC. ID. No. 65, SEC. ID. No. 67, SEC. ID. No. 69, SEC. ID. #75, SEC. ID. No. 85, SEC. ID. No. 87, SEC. ID. No. 89, SEC. ID. No. 91, SEC. ID. No. 93, SEC. ID. #95, SEC. ID. No. 97, SEC. ID. No. 99, SEC. ID. No. 101, SEC. ID. No. 103, SEC. ID. No. 105, SEC. ID. no. 107 or SEC. ID. #109; or (ii) at least 80% with respect to the SEC. ID NO. 111, SEC. ID NO. 113, SEC. ID. No. 115, SEC. ID. No. 119, SEC. ID. No. 125 or SEC. ID. No. 127; or (iii) at least 85% identity with respect to the SEC. ID. No. 121 or SEC. ID. #123; or (iv) at least 90% identity with respect to the SEC. ID. No. 2, SEC. ID. No. 4, SEC. ID. No. 6, SEC. ID. No. 8, SEC. ID. No. 10, SEC. ID. No. 14, SEC. ID. No. 34, SEC. ID. No. 43, SEC. ID. No. 46, SEC. ID. No. 48, SEC. ID. No. 50, SEC. ID. No. 57, SEC. ID. No. 71, SEC. ID. No. 73, SEC. ID. No. 77, SEC. ID. No. 79, SEQ NO:81 or SEC. ID. #117; or (v) at least 93% identity with respect to the SEC. ID. No. 12, SEC. ID. No. 16, SEC. ID. No. 30 and SEC. ID. #59; or (vi) at least 94% identity with respect to the SEC. ID. No. 53 and SEC. ID. #55; or (vii) at least 99% identity with respect to the SEC. ID. No. 32, SEC. ID. No. 61 or SEC. ID. #83; or (c) said polynucleotide segment is hybridized under stringent hybridization conditions with the complement of the nucleotide sequence of the SEQ. ID. No. 35, SEC. ID. No. 36, SEC. ID. No. 37, SEC. ID. No. 38, SEC. ID. No. 39, SEC. ID. No. 40, SEC. ID. No. 41, SEC. ID. No. 42, SEC. ID. No. 44, SEC. ID. No. 45, SEC. ID. No. 47, SEC. ID. No. 49, SEC. ID. No. 51,SEC. ID. No. 52, SEC. ID. No. 54, SEC. ID. No. 56, SEC. ID. No. 58, SEC. ID. No. 60, SEC. ID. No. 62, SEC. ID. No. 64, SEC. ID. No. 66, SEC. ID. No. 68, SEC. ID. No. 76, SEC. ID. No. 78, SEC. ID. No. 80,SEC. ID. No. 82, SEC. ID. No. 84, SEC. ID. No. 86, SEC. ID. No. 88, SEC. ID. No. 90, SEC. ID. No. 92,SEC. ID. No. 94, SEC. ID. No. 96, SEC. ID. No. 98, SEC. ID. No. 100, SEC. ID. No. 102, SEC. ID. No. 104, SEC. ID. No. 106, SEC. ID. No. 108, SEC. ID. No. 110, SEC. ID. No. 112, SEC. ID. No. 114, SEC. ID. No. 116, SEC. ID. No. 118, SEC. ID. No. 120, SEC. ID. No. 122, SEC. ID. No. 124 or SEC. ID. #126; or (d) said plant presents a detectable amount of said pesticidal protein. In certain embodiments, the pesticidal protein comprises the SEC. ID. No. 2, SEC. ID. No. 4, SEC. ID. No. 6, SEC. ID. No. 8, SEC. ID. No. 10, SEC. ID. No. 12, SEC. ID. No. 14, SEC. ID. No. 16, SEC. ID. No. 18, SEC. ID. No. 20, SEC. ID. No. 22, SEC. ID. No. 24, SEC. ID. No. 26, SEC. ID. No. 28, SEC. ID. No. 30, SEC. ID. No. 32, SEC. ID. No. 34, SEC. ID. No. 43, SEC. ID. No. 46, SEC. ID. No. 48, SEC. ID. No. 50,SEC. ID. No. 53, SEC. ID. No. 55, SEC. ID. No. 57, SEC. ID. No. 59, SEC. ID. No. 61, SEC. ID. No. 63, SEC. ID. No. 65, SEC. ID. No. 67, SEC. ID. No. 69, SEC. ID. No. 71, SEC. ID. No. 73, SEC. ID. No. 75, SEC. ID. No. 77, SEC. ID. No. 79, SEC. ID. No. 81, SEC. ID. No. 83, SEC. ID. No. 85, SEC. ID. No. 87, SEC. CQCLLn / LZnZ / E / Yli ID. No. 89, SEC. ID. No. 91, SEC. ID. No. 93, SEC. ID. No. 95, SEC. ID. No. 97, SEC. ID. No. 99, SEC. ID. No. 101, SEC. ID. No. 103, SEC. ID. No. 105, SEC. ID. No. 107, SEC. ID. No. 109, SEC. ID. No. 111, SEC. ID. No. 113, SEC. ID. No. 115, SEC. ID. No. 117, SEC. ID. No. 119, SEC. ID. No. 121, SEC. ID. No. 123, SEC. ID. No. 125 or SEC. ID. No. 127. In one embodiment, the plant is neither monocotyledonous nor dicotyledonous. In another embodiment, the plant is selected from the group consisting of alfalfa, banana, barley, beans, broccoli, cabbage, Brassica, carrot, tapioca, castor bean, cauliflower, celery, chickpea, Chinese cabbage, citrus plant, coconut, coffee, corn, clover, cotton, cucurbit, cucumber, Douglas fir, eggplant, eucalyptus, flax, garlic, grape, hops, leek, lettuce, bronco pine, millet, melons, walnut, oats, olive, onion, ornamental plants, palm tree , pasture grass, pea, peanut, pepper, pigeonpea, pine, potato, poplar, pumpkin, pine, radish, rapeseed, rice, roots, rye, safflower, bush, sorghum, southern pine, soybean, spinach, pumpkin, strawberry, sugar beet, sugar cane, sunflower, sweet corn, American storax, sweet potato, meadow grass, tea, tobacco, tomato, triticale, lawn grass, watermelon and wheat. In other embodiments, seeds comprising the recombinant nucleic acid molecules are described. In another embodiment, an insect inhibitor composition comprising the recombinant nucleic acid molecules described in the present application is contemplated. The insect inhibitor composition may further comprise a nucleotide sequence that encodes at least one additional pesticidal agent other than said pesticidal protein. The additional pesticidal agent(s) are selected from the group consisting of an insect inhibitory protein, an insect inhibitory dsRNA molecule and an auxiliary protein. The additional pesticidal agent(s) in the insect inhibitor composition exhibit activity against one or more pest species from the orders Lepidoptera, Coleoptera or Hemiptera. The additional pesticidal agent(s) in the insect inhibiting composition in one embodiment is selected from the group consisting of CrylA, CrylAb, CrylAc, CrylA.105, CrylAe, CrylB, CrylC, variants of CrylC, CrylD, CrylE, CrylF, chimeras of CrylA / F, CrylG, CrylH, Cryll, CrylJ, CrylK, CrylL, Cry2A, Cry2Ab, Cry2Ae, Cry3, variants of Cry3A, Cry3B, Cry4B, Cry6, Cry7, Cry8, Cry9, Cryl5, Cry34, Cry35, Cry43A, Cry43B, Cry51Aal, ΕΓ29, ΕΓ33, ET34, ET35, ΕΓ66, ΕΓ70, TIC400, TIC407, TIC417, TIC431, TIC800, TIC807, TIC834, TIC853, TIC900, TIC901, TIC1201, TIC1415 , TIC2160, TIC3131, TIC836, TIC860, TIC867, TIC869, TIC1100, VIP3A, VIP3B, VIP3Ab, AXMI-AXMI-, AXMI-88, AXMI-97, AXMI102, AXMI-112, AXMI-117, AXMI-100, AXMI-115, AXMI-113 and AXMI-005, AXMI134, AXMI -150, AXMI171, AXMI-184, AXMI-196, AXMI-204, AXMI-207, AXMI-209, AXMI-205, AXMI-218, AXMI-220, AXMI221z, ΑΧΜΙ-222Ζ, AXMI-223z, AXMI-224z and AXMI-225z, AXMI-238, AXMI-270, AXMI-279, AXMI345, AXMI-335, AXMI-R1 and variants thereof, IP3 and variants thereof, DIG-3, DIG-5, DIG-10, DIG657 DIG-11, Cry71Aal, Cry72Aal, PHI-4 variants, PIP-72 variants, PIP-45 variants, CQCLLn / LZnZ / E / Yli PIP-64 variants, PIP-74 variants, PIP-75 variants, PIP-77 variants, Axm¡422, Dig305, Axm¡440, PIP-47 variants, Axmi281, BT -009, BT-0012, BT-0013, BT-0023, BT0067, BT0044, BT-0051, BT-0068, BT-0128, DIG-17, DIG-90, DIG-79, CrylJP578V, CrylJPSl and Cryl JPS1P578V. Commodities comprising a detectable amount of the recombinant nucleic acid molecules described herein are contemplated. These commodities include basic corn packaged by a grain handler, corn flakes, corn cakes, corn flour, corn syrup, corn oil, corn silage, corn starch, corn cereal and the like, as well as corresponding cotton commodities such as whole or processed cotton seed, cotton oil, lint, seeds and plant parts processed for food or meal, fiber, paper, biomasses and fuel products, such as fuel derived from cotton oil or sludge derived from cotton ginning waste, as well as the corresponding soybean commodities such as whole or processed soybean seed, soybean oil, soybean protein, soybean meal, soybean flakes, soybean bran, soymilk, tofu cheese, soy wine, soy animal feed, soy paper, soy cream, soy biomass and fuel products produced from soy plants and parts of soy plants, as well as the basic products of rice, wheat, sorghum, pigeon peas, peanut, fruit, melon and vegetables, including juices, concentrates, jams, jellies and other edible forms of said commodities with a detectable amount of said polynucleotides and / or polypeptides of the present application, where applicable. Also contemplated in the present application is a method of producing a seed with the recombinant nucleic acid molecules described in the present application. The method comprises planting at least one seed with the recombinant nucleic acid molecules described in the present application, growing the plant from the seed and harvesting the seed from the plants, wherein the harvested seed comprises the recombinant nucleic acid molecules in this application. In another illustrative embodiment, a plant resistant to insect infestation is provided, wherein the cells of said plant comprise: (a) a recombinant nucleic acid molecule encoding an insecticidal effective amount of a pesticidal protein as indicated in the SEC. ID. No. 2, SEC. ID. No. 4, SEC. ID. No. 6, SEC. ID. No. 8, SEC. ID. No. 10, SEC. ID. No. 12, SEC. ID. No. 14, SEC. ID. No. 16, SEC. ID. No. 18, SEC. ID. No. 20, SEC. ID. No. 22, SEC. ID. No. 24, SEC. ID. No. 26, SEC. ID. No. 28, SEC. ID. No. 30, SEC. ID. No. 32, SEC. ID. No. 34, SEC. ID. No. 43, SEC. ID. No. 46, SEC. ID. No. 48, SEC. ID. No. 50, SEC. ID. No. 53, SEC. ID. No. 55, SEC. ID. No. 57, SEC. ID. No. 59, SEC. ID. No. 61, SEC. ID. No. 63, SEC. ID. No. 65, SEC. ID. No. 67, SEC. ID. No. 69, SEC. ID. No. 71, SEC. ID. No. 73, SEC. ID. No. 75, SEC. ID. No. 77, SEC. ID. No. 79, SEC. ID. No. 81, SEC. ID. No. 83, SEC. ID. No. 85, SEC. ID. No. 87, SEC. ID. No. 89, SEC. ID. No. 91, SEC. ID. No. 93, SEC. CQCLLn / LZnZ / E / Yli ID. No. 95, SEC. ID. No. 97, SEC. ID. No. 99, SEC. ID. No. 101, SEC. ID. No. 103, SEC. ID. No. 105, SEC. ID. No. 107, SEC. ID. No. 109, SEC. ID. No. 111, SEC. ID. No. 113, SEC. ID. No. 115, SEC. ID. No. 117, SEC. ID. No. 119, SEC. ID. No. 121, SEC. ID. No. 123, SEC. ID. No. 125 or SEC. ID. #127; or (b) an insecticidal effective amount of a protein comprising an amino acid sequence with: (i) at least 75% identity with respect to the SECs. ID. No. 18, SEC. ID. no. 20, SEC. ID. No. 22, SEC. ID. No. 24, SEC. ID. No. 26, SEC. ID. No. 28, SEC. ID. No. 63, SEC. ID.No. 65, Sec. ID. No. 67, SEC. ID. No. 69, SEC. ID. No. 75, SEC. ID. No. 85, SEC. ID. No. 87, SEC. ID.No. 89, SEC. ID. No. 91, SEC. ID. No. 93, SEC. ID. No. 95, SEC. ID. No. 97, SEC. ID. No. 99, SEC. ID.No. 101, SEC. ID. No. 103, SEC. ID. No. 105, SEC. ID. No. 107 or SEC. ID. #109; or (ii) at least 80% with respect to the SEC. ID NO. 111, SEC. ID NO. 113, SEC. ID. No. 115, SEC. ID. No. 119, SEC. ID. No. 125 or SEC. ID. No. 127 or (i¡¡) at least 85% identity to SEQ. ID. No. 121, SEC. ID. No. 123, or (iv) at least 90% identity to SEQ. ID. No. 2, SEC. ID. No. 4, SEC. ID. No. 6, SEC. ID. No. 8, SEC. ID. No. 10, SEC. ID. No. 14, SEC. ID. No. 34, SEC. ID. No. 43, SEC. ID. No. 46, SEC. ID. No. 48, SEC. ID. No. 50, SEC. ID. No. 57, SEC. ID. No. 71, SEC. ID. No. 73, SEC. ID. No. 77, SEC. ID. No. 79, SEC. ID. No. 81 or SEC. ID. No. 117, or (v) at least 93% identity to SEQ. ID. No. 12, SEC. ID. No. 16, SEC. ID. No. 30 and SEC. ID. No. 59 or (iv) at least 94% identity to SEQ. ID. No. 53 and SEC. ID. #55; or (vii) at least 99% identity to SEQ. ID. No. 32, SEC. ID No. 61 or SEQ. ID#83. The present application also describes methods for controlling a pest of the Coleoptera or Lepidoptera species and controlling an infestation of a plant with a pest of the Coleoptera or Lepidoptera species, in particular a crop plant. The method comprises, in one embodiment, (a) contacting the pest with an insecticidally effective amount of one or more pesticidal proteins as set forth in the SEC. ID. No. 2, SEC. ID. No. 4, SEC. ID. No. 6, SEC. ID. No. 8, SEC. ID. No. 10, SEC. ID. No. 12, SEC. ID. No. 14, SEC. ID. No. 16, SEC. ID. No. 18, SEC. ID. No. 20, SEC. ID. No. 22, SEC. ID. No. 24, SEC. ID. No. 26, SEC. ID. No. 28, SEC. ID. No. 30, SEC. ID. No. 32, SEC. ID. No. 34, SEC. ID. No. 43, SEC. ID. No. 46, SEC. ID. No. 48, SEC. ID. No. 50,SEC. ID. No. 53, SEC. ID. No. 55, SEC. ID. No. 57, SEC. ID. No. 59, SEC. ID. No. 61, SEC. ID. No. 63, SEC. ID. No. 65, SEC. ID. No. 67, SEC. ID. No. 69, SEC. ID. No. 71, SEC. ID. No. 73, SEC. ID. No. 75, SEC. ID. No. 77, SEC. ID. No. 79, SEC. ID. No. 81, SEC. ID. No. 83, SEC. ID. No. 85, SEC. ID. No. 87, SEC. ID. No. 89, SEC. ID. No. 91, SEC. ID. No. 93, SEC. ID. No. 95, SEC. ID. No. 97, SEC. ID. No. 99,SEC. ID. No. 101, SEC. ID. No. 103, SEC. ID. No. 105, SEC. ID. No. 107, SEC. ID. No. 109, SEC. ID. no. 111, SEC. ID. No. 113, SEC. ID. No. 115, SEC. ID. No. 117, SEC. ID. No. 119, SEC. ID. No. 121, SEC. ID. No. 123, SEC. ID. No. 125 or SEC. ID. #127; or (b) contacting the pest with an insecticidally effective amount of one or more pesticidal proteins comprising an amino acid sequence with: (i) at least 75% identity with respect to the SECs. ID. No. 18, SEC. ID. no. CQCLLn / LZnZ / E / Yli 20, SEC. ID. No. 22, SEC. ID. No. 24, SEC. ID. No. 26, SEC. ID. No. 28, SEC. ID. No. 63, SEC. ID. no. 65, SEC. ID. No. 67, SEC. ID. No. 69, SEC. ID. No. 75, SEC. ID. No. 85, SEC. ID. No. 87, SEC. ID. no. 89, SEC. ID. No. 91, SEC. ID. No. 93, SEC. ID. No. 95, SEC. ID. No. 97, SEC. ID. No. 99, SEC. ID. no. 101, SEC. ID. No. 103, SEC. ID. No. 105, SEC. ID. No. 107 or SEC. ID. #109; or (ii) at least 80% with respect to the SEC. ID NO. 111, SEC. ID NO. 113, SEC. ID. No. 115, SEC. ID. No. 119, SEC. ID. No. 125 or SEC. ID. No. 127 or (iii) at least 85% identity with respect to the SECs. ID. No. 121, SEC. ID. No. 123, or (iv) at least 90% identity with respect to the SECs. ID. No. 2, SEC. ID. No. 4, SEC. ID. No. 6, SEC. ID. No. 8, SEC. ID. No. 10, SEC. ID. No. 14, SEC. ID. No. 34, SEC. ID. No. 43, SEC. ID. No. 46, SEC. ID. No. 48, SEC. ID. No. 50, SEC. ID. No. 57, SEC. ID. No. 71, SEC. ID. No. 73, SEC. ID. No. 77, SEC. ID. No. 79, SEC. ID. No. 81 or SEC. ID. No. 117, or (v) at least 93% identity with respect to the SECs. ID. No. 12, SEC. ID. No. 16, SEC. ID. No. 30 and SEC. ID. #59 or (iv) at least 94% identity with respect to the SECs. ID. No. 53 and SEC. ID. #55; or (vii) at least 99% identity with respect to the SECs. ID. No. 32, SEC. ID #61 or SEC. ID #83. Further provided herein is a method for detecting the presence of a recombinant nucleic acid molecule comprising a polynucleotide segment encoding a pesticidal protein or a fragment thereof, wherein: (a) said pesticidal protein comprises the sequence of amino acids of the SEC. ID. No. 2, SEC. ID. No. 4, SEC. ID. No. 6, SEC. ID. No. 8, SEC. ID. No. 10, SEC. ID. No. 12, SEC. ID. No. 14, SEC. ID. No. 16, SEC. ID. No. 18, SEC. ID. No. 20, SEC. ID. No. 22, SEC. ID. No. 24, SEC. ID. No. 26, SEC. ID. No. 28, SEC. ID. No. 30,SEC. ID. No. 32, SEC. ID. No. 34, SEC. ID. No. 43, SEC. ID. No. 46, SEC. ID. No. 48, SEC. ID. No. 50,SEC. ID. No. 53, SEC. ID. No. 55, SEC. ID. No. 57, SEC. ID. No. 59, SEC. ID. No. 61, SEC. ID. No. 63, SEC. ID. No. 65, SEC. ID. No. 67, SEC. ID. No. 69, SEC. ID. No. 71, SEC. ID. No. 73, SEC. ID. No. 75, SEC. ID. No. 77, SEC. ID. No. 79, SEC. ID. No. 81, SEC. ID. No. 83, SEC. ID. No. 85, SEC. ID. No. 87, SEC. ID. No. 89, SEC. ID. No. 91, SEC. ID. No. 93, SEC. ID. No. 95, SEC. ID. No. 97, SEC. ID. No. 99,SEC. ID. No. 101, SEC. ID. No. 103, SEC. ID. No. 105, SEC. ID. No. 107, SEC. ID. No. 109, SEC. ID. no. 111, SEC. ID. No. 113, SEC. ID. No. 115, SEC. ID. No. 117, SEC. ID. No. 119, SEC. ID. No. 121,SEC. ID. No. 123, SEC. ID. No. 125 or SEC. ID. #127; or (b) said pesticidal protein comprises an amino acid sequence with: (i) at least 75% identity with respect to SEC. ID. No. 18, SEC. ID. No. 20, SEC. ID. No. 22, SEC. ID. No. 24, SEC. ID. No. 26, SEC. ID. No. 28, SEC. ID. #63, SEC. ID. No. 65, SEC. ID. No. 67, SEC. ID. No. 69, SEC. ID. No. 75, SEC. ID. No. 85, SEC. ID. #87, SEC. ID. No. 89, SEC. ID. No. 91, SEC. ID. No. 93, SEC. ID. No. 95, SEC. ID. No. 97, SEC. ID. #99, SEC. ID. No. 101, SEC. ID. No. 103, SEC. ID. No. 105, SEC. ID. No. 107 or SEC. ID. #109; or (i) at least 80% with respect to the SEC. ID NO. 111, SEC. ID NO. 113, SEC. ID. No. 115, SEC. ID. No. 119, SEC. ID. No. 125 or SEC. ID. #127; or (iii) at least 85% identity with respect to the SEC. ID. No. 121 or SEC. ID. #123; or (iv) at least 90% identity with respect to the SEC. ID. No. 2, SEC. CQCLLn / LZnZ / E / Yli ID. No. 4, SEC. ID. No. 6, SEC. ID. No. 8, SEC. ID. No. 10, SEC. ID. No. 14, SEC. ID. No. 34, SEC. ID. No. 43, SEC. ID. No. 46, SEC. ID. No. 48, SEC. ID. No. 50, SEC. ID. No. 57, SEC. ID. No. 71, SEC. ID. No. 73, SEC. ID. No. 77, SEC. ID. No. 79, SEQ NO:81 or SEC. ID. #117; or (v) at least 93% identity with respect to the SEC. ID. No. 12, SEC. ID. No. 16, SEC. ID. No. 30 and SEC. ID. #59; or (vi) at least 94% identity with respect to the SEC. ID. No. 53 and SEC. ID. #55; or (vii) at least 99% identity with respect to the SEC. ID. No. 32, SEC. ID. No. 61 or SEC. ID. #83; or (c) said polynucleotide segment is hybridized with a polynucleotide with the nucleotide sequence of SEQ. ID. No. 1, SEC. ID. #3, SEC. ID. No. 5, SEC. ID. No. 7, SEC. ID. No. 9, SEC. ID. No. 11, SEC. ID. No. 13, SEC. ID. No. 15, SEC. ID. No. 17, SEC. ID. No. 19, SEC. ID. No. 21, SEC. ID. No. 23, SEC. ID. No. 25, SEC. ID. No. 27, SEC. ID. No. 29, SEC. ID. No. 31, SEC. ID. No. 33, SEC. ID. No. 35, SEC. ID. No. 36, SEC. ID. No. 37, SEC. ID. No. 38, SEC. ID. No. 39, SEC. ID. No. 40, SEC. ID. No. 41,SEC. ID. No. 42, SEC. ID. No. 44, SEC. ID. No. 45, SEC. ID. No. 47, SEC. ID. No. 49, SEC. ID. No. 51,SEC. ID. No. 52, SEC. ID. No. 54, SEC. ID. No. 56, SEC. ID. No. 58, SEC. ID. No. 60, SEC. ID. No. 62, SEC. ID. No. 64, SEC. ID. No. 66, SEC. ID. No. 68, SEC. ID. No. 70, SEC. ID. No. 72, SEC. ID. No. 74, SEC. ID. No. 76, SEC. ID. No. 78, SEC. ID. No. 80, SEC. ID. No. 82, SEC. ID. No. 84, SEC. ID. No. 86, SEC. ID. No. 88, SEC. ID. No. 90, SEC. ID. No. 92, SEC. ID. No. 94, SEC. ID. No. 96, SEC. ID. No. 98,SEC. ID. No. 100, SEC. ID. No. 102, SEC. ID. No. 104, SEC. ID. No. 106, SEC. ID. No. 108, SEC. ID. No. 110, SEC. ID. No. 112, SEC. ID. No. 114, SEC. ID. No. 116, SEC. ID. No. 118, SEC. ID. No. 120, SEC. ID. No. 122, SEC. ID. No. 124 or SEC. ID. No. 126. In one embodiment of the invention, the method comprises contacting a sample of the nucleic acids with a nucleic acid probe that hybridizes under stringent hybridization conditions with genomic DNA of a plant with a polynucleotide segment that encodes a pesticidal protein or fragment thereof provided herein that does not hybridize under said hybridization conditions to genomic DNA from a plant that is otherwise isogenic and without the segment, in which the probe is homologous or complementary of the SECs. ID. No. 35, SEC. ID. No. 36, SEC. ID. No. 37, SEC. ID. No. 38, SEC. ID. No. 39, SEC. ID. No. 40, SEC. ID. No. 41, SEC. ID. No. 42, SEC. ID. No. 44, SEC. ID. No. 45, SEC. ID. No. 47, SEC. ID. No. 49, SEC. ID. No. 51, SEC. ID. No. 52, SEC. ID. No. 54, SEC. ID. no. 56, SEC. ID. No. 58, SEC. ID. No. 60, SEC. ID. No. 62, SEC. ID. No. 64, SEC. ID. No. 66, SEC. ID.No. 68, SEC. ID. No. 76, SEC. ID. No. 78, SEC. ID. No. 80, SEC. ID. No. 82, SEC. ID. No. 84, SEC. ID.No. 86, SEC. ID. No. 88, SEC. ID. No. 90, SEC. ID. No. 92, SEC. ID. No. 94, SEC. ID. No. 96, SEC. ID.No. 98, SEC. ID. No. 100, SEC. ID. No. 102, SEC. ID. No. 104, SEC. ID. No. 106, SEC. ID. No. 108, SEC. ID. No. 110, SEC. ID. No. 112, SEC. ID. No. 114, SEC. ID. No. 116, SEC. ID. No. 118, SEC. ID. No. 120, SEC. ID. No. 122, SEC. ID. No. 124 or SEC. ID. No. 126, or a sequence that encodes a pesticidal protein with an amino acid sequence with: (i) at least 75% identity with respect to SEC. ID. No. 18, SEC. ID. No. 20, SEC. ID. No. 22, SEC. ID. No. 24, SEC. ID. #26, CQCLLn / LZnZ / E / Yli SEC. ID. No. 28, SEC. ID. No. 63, SEC. ID. No. 65, SEC. ID. No. 67, SEC. ID. No. 69, SEC. ID. #75, SEC. ID. No. 85, SEC. ID. No. 87, SEC. ID. No. 89, SEC. ID. No. 91, SEC. ID. No. 93, SEC. ID. #95, SEC. ID. No. 97, SEC. ID. No. 99, SEC. ID. No. 101, SEC. ID. No. 103, SEC. ID. No. 105, SEC. ID. no. 107 or SEC. ID. #109; or (ii) at least 80% with respect to the SEC. ID No. lll, SEQ. ID #113, SEC. ID. No. 115, SEC. ID. No. 119, SEC. ID. No. 125 or SEC. ID. No. 127 or (iii) at least 85% identity with respect to the SECs. ID. No. 121, SEC. ID. No. 123, or (iv) at least 90% identity to SEQ. ID. No. 2, SEC. ID. No. 4, SEC. ID. No. 6, SEC. ID. No. 8, SEC. ID. No. 10, SEC. ID. No. 14, SEC. ID. No. 34, SEC. ID. No. 43, SEC. ID. No. 46, SEC. ID. No. 48, SEC. ID. No. 50, SEC. ID. No. 57, SEC. ID. No. 71, SEC. ID. No. 73, SEC. ID. No. 77, SEC. ID. No. 79, SEC. ID. No. 81 or SEC. ID. No. 117, or (v) at least 93% identity with respect to the SECs. ID. No. 12, SEC. ID. No. 16, SEC. ID. No. 30 and SEC. ID. No. 59 or (iv) at least 94% identity to SEQ. ID. No. 53 and SEC. ID. #55; or (vii) at least 99% identity to SEQ. ID. No. 32, SEC. ID No. 61 or SEQ. ID No. 83. The method may further comprise (a) subjecting the sample and the probe to stringent hybridization conditions and (b) detecting hybridization of the probe with the DNA of the sample. The invention also provides methods for detecting the presence of a pesticidal protein or a fragment thereof in a protein sample, wherein said pesticidal protein comprises the amino acid sequence of SEC. ID. No. 2, SEC. ID. No. 4, SEC. ID. No. 6, SEC. ID. No. 8, SEC. ID. No. 10, SEC. ID. No. 12, SEC. ID. No. 14, SEC. ID. No. 16, SEC. ID. No. 18, SEC. ID. No. 20, SEC. ID. No. 22, SEC. ID. No. 24, SEC. ID. No. 26, SEC. ID. No. 28, SEC. ID. No. 30, SEC. ID. No. 32, SEC. ID. No. 34, SEC. ID. No. 43, SEC. ID. No. 46, SEC. ID. No. 48, SEC. ID. No. 50,SEC. ID. No. 53, SEC. ID. No. 55, SEC. ID. No. 57, SEC. ID. No. 59, SEC. ID. No. 61, SEC. ID. No. 63, SEC. ID. No. 65, SEC. ID. No. 67, SEC. ID. No. 69, SEC. ID. No. 71, SEC. ID. No. 73, SEC. ID. No. 75, SEC. ID. No. 77, SEC. ID. No. 79, SEC. ID. No. 81, SEC. ID. No. 83, SEC. ID. No. 85, SEC. ID. No. 87, SEC. ID. No. 89, SEC. ID. No. 91, SEC. ID. No. 93, SEC. ID. No. 95, SEC. ID. No. 97, SEC. ID. No. 99, SEC. ID. No. 101, SEC. ID. No. 103, SEC. ID. No. 105, SEC. ID. No. 107, SEC. ID. No. 109, SEC. ID. No. lll, SEC. ID. No. 113, SEC. ID. No. 115, SEC. ID. No. 117, SEC. ID. No. 119, SEC. ID. No. 121, SEC. ID. No. 123, SEC. ID. No. 125 or SEC. ID. #127; or said pesticidal protein comprises an amino acid sequence with: (i) at least 75% identity with respect to SEC. ID. No. 18, SEC. ID. No. 20, SEC. ID. No. 22, SEC. ID. No. 24, SEC. ID. No. 26, SEC. ID. No. 28, SEC. ID. #63, SEC. ID. No. 65, SEC. ID. No. 67, SEC. ID. No. 69, SEC. ID. No. 75, SEC. ID. No. 85, SEC. ID. #87, SEC. ID. No. 89, SEC. ID. No. 91, SEC. ID. No. 93, SEC. ID. No. 95, SEC. ID. No. 97, SEC. ID. #99, SEC. ID. No. 101, SEC. ID. No. 103, SEC. ID. No. 105, SEC. ID. No. 107 or SEC. ID. #109; or (ii) at least 80% with respect to the SEC. ID No. lll, SEQ. ID NO. 113, SEC. ID. No. 115, SEC. ID. No. 119, SEC. ID. No. 125 or SEC. ID. No. 127 or (iii) at least 85% identity with respect to the SECs. ID. CQCLLn / LZnZ / E / Yli η.° 121, SEC. ID. No. 123, or (iv) at least 90% identity to SEQ. ID. No. 2, SEC. ID. No. 4, SEC. ID. No. 6, SEC. ID. No. 8, SEC. ID. No. 10, SEC. ID. No. 14, SEC. ID. No. 34, SEC. ID. No. 43, SEC. ID. No. 46, SEC. ID. No. 48, SEC. ID. No. 50, SEC. ID. No. 57, SEC. ID. No. 71, SEC. ID. No. 73, SEC. ID. No. 77, SEC. ID. No. 79, SEC. ID. No. 81 or SEC. ID. No. 117, or (v) at least 93% identity with respect to the SECs. ID. No. 12, SEC. ID. No. 16, SEC. ID. No. 30 and SEC. ID. No. 59 or (iv) at least 94% identity to SEQ. ID. No. 53 and SEC. ID. #55; or (vii) at least 99% identity to SEQ. ID. No. 32, SEC. ID No. 61 or SEQ. ID #83. In one embodiment, the method comprises: (a) contacting a sample with an immunoreactive antibody and (b) detecting the presence of the protein. In some embodiments, the detection step comprises an ELISA or a Western blot. Brief Description of the Sequences The SEC. ID. #1 is a nucleic acid sequence obtained from Brevibacillus laterosporus strain DSC005019, which encodes a pesticidal protein sequence TIC7040. The SEC. ID. #2 is the amino acid sequence of protein TIC7040. The SEC. ID. #3 is a nucleic acid sequence obtained from Brevibacillus laterosporus strain DSC005019, which encodes a pesticidal protein sequence TIC7040HT. The SEC. ID. #4 is the amino acid sequence of protein TIC7040HT. The SEC. ID. #5 is a nucleic acid sequence encoding a TIC7040_4 pesticidal protein sequence comprising a C-terminal truncation with respect to the TIC7040HT protein. The SEC. ID. #6 is the amino acid sequence of the TIC7040_4 protein, consisting of amino acids 1 to 671 of TIC7040HT. The SEC. ID. #7 is a nucleic acid sequence encoding a pesticidal protein sequence TIC7040_5 comprising an N-terminal and C-terminal truncation with respect to the TIC7040HT protein. The SEC. ID. #8 is the amino acid sequence of the TIC7040_5 protein, comprising amino acids 13 to 611 of TIC7040HT. The SEC. ID. #9 is a nucleic acid sequence encoding a pesticidal protein sequence TIC7040_6 comprising an N-terminal and C-terminal truncation with respect to the TIC7040HT protein. The SEC. ID. #10 is the amino acid sequence of the TIC7040_6 protein, comprising amino acids 13 to 671 of TIC7040HT. The SEC. ID. #11 is a nucleic acid sequence obtained from Brevibacillus laterosporus strain DSC005973, which encodes a pesticidal protein sequence TIC7042. The SEC. ID. #12 is the amino acid sequence of protein TIC7042. CQCLLn / LZnZ / E / Yli The SEC. ID. #13 is a nucleic acid sequence obtained from BrevíbacíHus laterosporus strain DSC006713, which encodes a pesticidal protein sequence TIC7381. The SEC. ID. #14 is the amino acid sequence of protein TIC7381. The SEC. ID. #15 is a nucleic acid sequence obtained from BrevíbacíHus laterosporus strain DSC007657, which encodes a pesticidal protein sequence TIC7382. The SEC. ID. #16 is the amino acid sequence of TIC7382 protein. The SEC. ID. #17 is a nucleic acid sequence obtained from BrevíbacíHus laterosporus strain DSC008106, which encodes a pesticidal protein sequence TIC7383. The SEC. ID. #18 is the amino acid sequence of protein TIC7383. The SEC. ID. #19 is a nucleic acid sequence encoding a TIC7383_2 protein comprising an N-terminal truncation with respect to the TIC7383 protein. The SEC. ID. #20 is the amino acid sequence of the TIC7383_2 protein, comprising amino acids 15 to 1256 of TIC7383. The SEC. ID. #21 is a nucleic acid sequence encoding a TIC7383_3 protein comprising an N-terminal truncation with respect to the TIC7383 protein. The SEC. ID. #22 is the amino acid sequence of the TIC7383_3 protein, consisting of amino acids 1 to 659 of TIC7383. The SEC. ID. #23 is a nucleic acid sequence encoding a TIC7383_4 protein comprising an N-terminal truncation with respect to the TIC7383 protein. The SEC. ID. #24 is the amino acid sequence of the TIC7383_4 protein, consisting of amino acids 1 to 679 of TIC7383. The SEC. ID. #25 is a nucleic acid sequence encoding a TIC7383_5 protein comprising an N-terminal and C-terminal truncation with respect to the TIC7383 protein. The SEC. ID. #26 is the amino acid sequence of the TIC7383_5 protein and comprises amino acids 15 to 659 of TIC7383. The SEC. ID. #27 is a nucleic acid sequence encoding a TIC7383_6 protein comprising an N-terminal and C-terminal truncation with respect to the TIC7383 protein. The SEC. ID. #28 is the amino acid sequence of the TIC7383_6 protein, comprising amino acids 15 to 679 of TIC7383. The SEC. ID. #29 is a nucleic acid sequence obtained from BrevíbacíHus laterosporus strain DSC007651, which encodes a pesticidal protein sequence TIC7386. The SEC. ID. #30 is the amino acid sequence of TIC7386 protein. The SEC. ID. #31 is a nucleic acid sequence obtained from BrevíbacíHus laterosporus strain DSC007962, which encodes a pesticidal protein sequence TIC7388. The SEC. ID. #32 is the amino acid sequence of TIC7388 protein. CQCLLn / LZnZ / E / Yli The SEC. ID. #33 is a nucleic acid sequence obtained from strain DSC006878 of BrevibaciHus laterosporus, which encodes a pesticidal protein sequence TIC7389. The SEC. ID. #34 is the amino acid sequence of TIC7389 protein. CQCLLn / LZnZ / E / Yli The SEC. ID. #35 is a synthetic coding sequence, CR-BREIa.TIC7040.nno_Mc:l, which encodes a pesticide protein TIC7040 used for expression in plant cells. The SEC. ID. #36 is BREIa.TIC7040_10.nno_Mc:l, which encodes expression in plant cells. The SEC. ID. #37 is BREIa.TIC7040_10.nno_Mc:3, which encodes expression in plant cells. The SEC. ID. #38 is BREIa.TIC7040_10.nno_Mc:4, which encodes expression in plant cells. The SEC. ID. #39 is BREIa.TIC7040_10.nno_Mc:5, which encodes expression in plant cells. The SEC. ID. #40 is BREIa.TIC7040_10.nno_Mc:6, which encodes expression in plant cells. The SEC. ID. #41 is BREIa.TIC7040_10.nno_Mc:7, which encodes expression in plant cells. The SEC. ID. #42 is a synthetic coding sequence, CRa TIC7040HT pesticide protein used for a synthetic coding sequence,CRa TIC7040HT pesticide protein used for a synthetic coding sequence,CRa TIC7040HT pesticide protein used for a synthetic coding sequence synthetic coding,CRa TIC7040HT pesticidal protein used for a synthetic coding sequence,CRa TIC7040HT pesticidal protein used for a synthetic coding sequence,CRa TIC7040HT pesticidal protein used for a synthetic coding sequence,CRBREIa.TIC7040_l.nno_Mc :l, which encodes a protein with an N-terminal and C-terminal truncation with respect to the TIC7040HT protein that is used for expression in plant cells. The SEC. ID. #43 is the amino acid sequence of the CRBREIa.TIC7040_l.nno_Mc:l protein, comprising amino acids 15 to 651 of TIC7040HT. The SEC. ID. #44 is a synthetic coding sequence, CRBREIa.TIC7040_2.nno_Mc:l, which encodes a pesticidal protein sequence TIC7040_6 (SEQ ID NO:10) comprising an N-terminal and C-terminal truncation with respect to the TIC7040HT protein that is used for expression in plant cells. The SEC. ID. #45 is a synthetic coding sequence, CRBREIa.TIC7040_ll.nno_Mc:l, which encodes a protein with an N-terminal and C-terminal truncation of the TIC7040HT protein that is used for expression in plant cells. The SEC. ID. #46 is the amino acid sequence of the CRBREIa.TIC7040_ll.nno_Mc:l protein, comprising amino acids 14 to 671 of TIC7040HT. The SEC. ID. #47 is a synthetic coding sequence, CRBREIa.TIC7040_12.nno_Mc:2, which encodes a protein with a C-terminal truncation from the TIC7040HT protein that is used for expression in plant cells. The SEC. ID. #48 is the amino acid sequence of the protein CRBREIa.TIC7040_12.nno_Mc:2, which consists of amino acids 1 to 660 of TIC7040HT. The SEC. ID. #49 is a synthetic coding sequence, CRBREIa.TIC7040_13.nno_Mc:l, which encodes a protein with a C-terminal truncation from the TIC7040HT protein that is used for expression in plant cells. The SEC. ID. #50 is the amino acid sequence of the protein CRBREIa.TIC7040_13.nno_Mc:l, which consists of amino acids 1 to 627 of TIC7040HT. The SEC. ID. #51 is a synthetic coding sequence, CR-BREIa.TIC7042.nno_Mc:l, which encodes a TIC7042 protein (SEQ ID NO:12) that is used for expression in plant cells. The SEC. ID. #52 is a synthetic coding sequence, CRBREIa.TIC7042_l.nno_Mc:l, which encodes a protein with an N-terminal and C-terminal truncation to the TIC7042 protein that is used for expression in plant cells. The SEC. ID. #53 is the amino acid sequence of the protein CRBREIa.TIC7042_l.nno_Mc:l, which comprises amino acids 11 to 646 of TIC7042. The SEC. ID. #54 is a synthetic coding sequence, CRBREIa.TIC7042_2.nno_Mc:l, which encodes a protein with an N-terminal and C-terminal truncation relative to the TIC7042 protein that is used for expression in plant cells. The SEC. ID. #55 is the amino acid sequence of the CRBREIa.TIC7042_2.nno_Mc:l protein, comprising amino acids 11 to 665 of TIC7042. The SEC. ID. #56 is a synthetic coding sequence, CRBREIa.TIC7381_l.nno_Mc:l, encoding a TIC7381 protein, in which an additional alanine is inserted immediately after the initial methionine codon used for expression in plant cells. The SEC. ID. #57 is the amino acid sequence of CR-BREIa.TIC7381_l.nno_Mc:l, in which an additional alanine amino acid is inserted immediately after the initial methionine with respect to the TIC7381 protein sequence. The SEC. ID. #58 is a synthetic coding sequence used for expression in plant cells, CR-BREIa.TIC7382_l.nno_Mc:l, encoding a TIC7382 protein, in which an additional alanine is inserted immediately after the initial methionine codon . CQCLLn / LZnZ / E / Yli The SEC. ID. #59 is the amino acid sequence of CR-BREIa.TIC7382_l.nno_Mc:l, in which an additional alanine amino acid is inserted immediately after the initial methionine with respect to the TIC7381 protein sequence. The SEC. ID. #60 is a synthetic coding sequence used for expression in plant cells, CR-BREIa.TIC7382_2.nno_Mc:l, which encodes a CRBREIa.TIC7382_2.nno_Mc:l protein comprising a C-terminal truncation with respect to the TIC7382 protein, in which an additional alanine is inserted immediately after the initial methionine codon. The SEC. ID. #61 is the amino acid sequence of CR-BREIa.TIC7382_2.nno_Mc:l, which comprises a C-terminal deletion and in which an additional alanine amino acid is inserted immediately after the initial methionine with respect to the sequence of TIC7382 protein and comprising amino acids 1 to 659 of TIC7382. The SEC. ID. #62 is a synthetic coding sequence, CRBREIa.TIC7383_l.nno_Mc:l, encoding a TIC7383 protein, in which an additional alanine is inserted immediately after the initial methionine codon used for expression in plant cells. The SEC. ID. #63 is the amino acid sequence of CR-BREIa.TIC7383_l.nno_Mc:l, in which an additional alanine amino acid is inserted immediately after the initial methionine with respect to the TIC7383 protein sequence. The SEC. ID. #64 is a synthetic coding sequence, CRBREIa.TIC7383_7.nno_Mc:l, encoding a CR-BREIa.TIC7383_7.nno_Mc:l protein comprising an N-terminal and C-terminal truncation with respect to the TIC7383 protein, in which an additional alanine is inserted immediately after the initial methionine codon that is used for expression in plant cells. The SEC. ID. #65 is the amino acid sequence of CR-BREIa.TIC7383_7.nno_Mc:l, which comprises an N-terminal and C-terminal deletion and in which an additional alanine amino acid is inserted immediately after the initial methionine with respect to the TIC7383 protein sequence and comprising amino acids 54 to 668 of TIC7383. The SEC. ID. #66 is a synthetic coding sequence, CRBREIa.TIC7383_8.nno_Mc:l, encoding a protein CR-BREIa.TIC7383_8.nno_Mc:l comprising a C-terminal truncation with respect to the TIC7383 protein, in which inserts an additional alanine immediately after the initial methionine codon that is used for expression in plant cells. The SEC. ID. #67 is the amino acid sequence of CR-BREIa.TIC7383_8.nno_Mc:l, which comprises a C-terminal deletion and into which an additional alanine amino acid is inserted CQCLLn / LZnZ / E / Yli immediately after the initial methionine with respect to the TIC7383 protein sequence and comprising amino acids 1 to 661 of TIC7383. The SEC. ID. #68 is a synthetic coding sequence, CRBREIa.TIC7383_9.nno_Mc:l, encoding a CR-BREIa.TIC7383_9.nno_Mc:l protein comprising a C-terminal truncation with respect to the TIC7383 protein, in which inserts an additional alanine immediately after the initial methionine codon that is used for expression in plant cells. The SEC. ID. #69 is the amino acid sequence of CR-BREIa.TIC7383_9.nno_Mc:l, which comprises a C-terminal deletion, in which an additional alanine amino acid is inserted immediately after the initial methionine with respect to the sequence of TIC7383 protein and comprising amino acids 1 to 668 of TIC7383. The SEC. ID. #70 is a coding sequence that encodes the tryptic core (TIC7040HT_Tryp) of the TIC7040HT protein, as determined by mass spectrometry. The SEC. ID. #71 is the amino acid sequence of the tryptic core (TIC7040HT_Tryp) of the TIC7040HT protein, as determined by mass spectrometry and comprises amino acids 43 to 624 of TIC7040HT. The SEC. ID. #72 is a coding sequence encoding the chymotryptic core (TIC7040HT_Chymo) of the TIC7040HT protein, as determined by mass spectrometry. The SEC. ID. #73 is the amino acid sequence of the chymotryptic core (TIC7040HT_Chymo) of the TIC7040HT protein, as determined by mass spectrometry and comprises amino acids 45 to 641 of TIC7040HT. The SEC. ID. #74 is a coding sequence encoding the tryptic core (TIC7383_Tryp) of the TIC7383 protein, as determined by mass spectrometry. The SEC. ID. #75 is the amino acid sequence of the tryptic core (TIC7383_Tryp) of the TIC7383 protein, as determined by mass spectrometry and comprises amino acids 55 to 668 of TIC7383. The SEC. ID. #76 is a synthetic coding sequence, CRBREIa.TIC7040_14.nno_Mc:l, encoding a CR-BREIa.TIC7040_14.nno_Mc:l protein with an N-terminal and C-terminal truncation relative to the TIC7040HT protein, in which that an additional alanine is inserted immediately after the initial methionine codon that is used for expression in plant cells. The SEC. ID. #77 is the amino acid sequence of the protein CRBREIa.TIC7040_14.nno_Mc:l, into which an additional alanine amino acid is inserted CQCLLn / LZnZ / E / Yli immediately after the initial methionine and comprises amino acids 52 to 660 of TIC7040HT. The SEC. ID. #78 is a synthetic coding sequence, CRBREIa.TIC7381_2.nno_Mc:l, encoding a protein CR-BREIa.TIC7381_2.nno_Mc:l with a C-terminal truncation relative to the TIC7381 protein, into which it is inserted an additional alanine immediately after the initial methionine codon that is used for expression in plant cells. The SEC. ID. #79 is the amino acid sequence of the protein CRBREIa.TIC7381_2.nno_Mc:l, in which an additional alanine amino acid is inserted immediately after the initial methionine and comprises amino acids 1 to 658 of TIC7381. The SEC. ID. #80 is a synthetic coding sequence, CRBREIa.TIC7381_3.nno_Mc:l, encoding a protein CR-BREIa.TIC7381_3.nno_Mc:l with an N-terminal and C-terminal truncation relative to the TIC7381 protein, in which that an additional alanine is inserted immediately after the initial methionine codon that is used for expression in plant cells. The SEC. ID. #81 is the amino acid sequence of the protein CRBREIa.TIC7381_3.nno_Mc:l, in which an additional alanine amino acid is inserted immediately after the initial methionine and comprises amino acids 50 to 658 of TICTIC7381. The SEC. ID. #82 is a synthetic coding sequence, CRBREIa.TIC7382_3.nno_Mc:l, encoding a protein CR-BREIa.TIC7382_3.nno_Mc:l with an N-terminal and C-terminal truncation relative to the TIC7382 protein, in which that an additional alanine is inserted immediately after the initial methionine codon that is used for expression in plant cells. The SEC. ID. #83 is the amino acid sequence of the protein CRBREIa.TIC7382_3.nno_Mc:l, in which an additional alanine amino acid is inserted immediately after the initial methionine and comprises amino acids 52 to 659 of TIC7382. The SEC. ID. #84 is a synthetic coding sequence, CRBREIa.TIC7383_19.nno_Mc:l, which encodes a protein CR-BREIa.TIC7383_19.nno_Mc:l with an N-terminal and C-terminal truncation with respect to the TIC7383 protein and which is used for expression in plant cells. The SEC. ID. #85 is the amino acid sequence of the protein CRBREIa.TIC7383_19.nno_Mc:l and comprises amino acids 15 to 668 of TIC7383. The SEC. ID. #86 is a synthetic coding sequence, CRBREIa.TIC7383_20.nno_Mc:l, which encodes a CR-BREIa.TIC7383_20.nno_Mc:l protein with a CQCLLn / LZnZ / E / Yli N-terminal and C-terminal truncation with respect to the TIC7383 protein and used for expression in plant cells. The SEC. ID. #87 is the amino acid sequence of the protein CRBREIa.TIC7383_20.nno_Mc:l and comprises amino acids 15 to 661 of TIC7383. The SEC. ID. #88 is a synthetic coding sequence, CRBREIa.TIC7383_21.nno_Mc:l, which encodes a protein CR-BREIa.TIC7383_21.nno_Mc:l with an N-terminal and C-terminal truncation with respect to the TIC7383 protein, in the that an additional alanine is inserted immediately after the initial methionine codon that is used for expression in plant cells. The SEC. ID. #89 is the amino acid sequence of the protein CRBREIa.TIC7383_21.nno_Mc:l, in which an additional alanine amino acid is inserted immediately after the initial methionine and comprises amino acids 54 to 661 of TIC7383. The SEC. ID. #90 is a synthetic coding sequence, CRBREIa.TIC7383_22.nno_Mc:l, which encodes a protein CR-BREIa.TIC7383_22.nno_Mc:l with an N-terminal and C-terminal truncation with respect to the TIC7383 protein and which is used for expression in plant cells. The SEC. ID. #91 is the amino acid sequence of the protein CRBREIa.TIC7383_22.nno_Mc:l and comprises amino acids 54 to 668 of TIC7383. The SEC. ID. #92 is a synthetic coding sequence, CRBREIa.TIC7383_23.nno_Mc:l, which encodes a protein CR-BREIa.TIC7383_23.nno_Mc:l with an N-terminal and C-terminal truncation with respect to the TIC7383 protein and which is used for expression in plant cells. The SEC. ID. #93 is the amino acid sequence of the protein CRBREIa.TIC7383_23.nno_Mc:l and comprises amino acids 54 to 661 of TIC7383. The SEC. ID. #94 is a synthetic coding sequence, CRBREIa.TIC7383_24.nno_Mc:2, which encodes a protein CR-BREIa.TIC7383_24.nno_Mc:2 with an N-terminal and C-terminal truncation with respect to the TIC7383 protein and which is used for expression in plant cells. The SEC. ID. #95 is the amino acid sequence of the protein CRBREIa.TIC7383_24.nno_Mc:2 and comprises amino acids 73 to 661 of TIC7383. The SEC. ID. #96 is a synthetic coding sequence, CRBREIa.TIC7383_25.nno_Mc:3, which encodes a protein CR-BREIa.TIC7383_25.nno_Mc:3 with an N-terminal and C-terminal truncation with respect to the TIC7383 protein and which is used for expression in plant cells. The SEC. ID. #97 is the amino acid sequence of the CRCQCLLn / LZnZ / E / Yli protein BREIa.TIC7383_25.nno_Mc:3 and comprises amino acids 94 to 661 of TIC7383. The SEC. ID. #98 is a synthetic coding sequence, CRBREIa.TIC7383_26.nno_Mc:l, which encodes a protein CR-BREIa.TIC7383_26.nno_Mc:l with an N-terminal and C-terminal truncation with respect to the TIC7383 protein and which is used for expression in plant cells. The SEC. ID. #99 is the amino acid sequence of the protein CRBREIa.TIC7383_26.nno_Mc:l and comprises amino acids 114 to 661 of TIC7383. The SEC. ID. #100 is a synthetic coding sequence, CRBREIa.TIC7383_27.nno_Mc:l, which encodes a protein CR-BREIa.TIC7383_27.nno_Mc:l with an N-terminal and C-terminal truncation with respect to the TIC7383 protein, in the that an additional alanine is inserted immediately after the initial methionine codon that is used for expression in plant cells. The SEC. ID. #101 is the amino acid sequence of the protein CRBREIa.TIC7383_27.nno_Mc:l, in which an additional alanine amino acid is inserted immediately after the initial methionine and comprises amino acids 54 to 658 of TIC7383. The SEC. ID. #102 is a synthetic coding sequence, CRBREIa.TIC7383_28.nno_Mc:l, which encodes a protein CR-BREIa.TIC7383_28.nno_Mc:l with an N-terminal and C-terminal truncation with respect to the TIC7383 protein and which is used for expression in plant cells. The SEC. ID. #103 is the amino acid sequence of the CRBREIa.TIC7383_28.nno_Mc:l protein and comprises amino acids 15 to 658 of TIC7383. The SEC. ID. #104 is a synthetic coding sequence, CRBREIa.TIC7383_29.nno_Mc:l, encoding a protein CR-BREIa.TIC7383_29.nno_Mc:l with a C-terminal truncation relative to the TIC7383 protein, into which it is inserted an additional alanine immediately after the initial methionine codon that is used for expression in plant cells. The SEC. ID. #105 is the amino acid sequence of the protein CRBREIa.TIC7383_29.nno_Mc:l, in which an additional alanine amino acid is inserted immediately after the initial methionine and comprises amino acids 1 to 963 of TIC7383. The SEC. ID. #106 is a synthetic coding sequence, CRBREIa.TIC7383_30.nno_Mc:l, encoding a protein CR-BREIa.TIC7383_30.nno_Mc:l, in which an additional alanine codon is inserted immediately after the initial methionine codon and comprising mutations of the codons corresponding to amino acid positions 964, 966 and 968 with respect to TIC7383 and which is used for expression in plant cells. The SEC. ID. #107 is the amino acid sequence of the CR protein CQCLLn / LZnZ / E / Yli BREIa.TIC7383_30.nno_Mc:l, in which an additional alanine amino acid is inserted immediately after the initial methionine and comprises the mutations K964A, R966A, K968A, with respect to TIC7383. The SEC. ID. #108 is a synthetic coding sequence, CRBREIa.TIC7383_31.nno_Mc:l, encoding a CR-BREIa.TIC7383_31.nno_Mc:l protein with a C-terminal truncation relative to the TIC7383 protein, into which it is inserted an additional alanine codon immediately after the initial methionine codon and comprising mutations of the codons corresponding to amino acid positions 964, 966 and 968 with respect to TIC7383 and which is used for expression in plant cells. The SEC. ID. #109 is the amino acid sequence of the protein CRBREIa.TIC7383_31.nno_Mc:l, in which an additional alanine amino acid is inserted immediately after the initial methionine and comprises amino acids 1 to 1065 and also includes the mutations K964A, R966A, K968A, with respect to TIC7383. The SEC. ID. #110 is a synthetic coding sequence, CRBREIa.TIC7383_32.nno_Mc:l, encoding a protein CR-BREIa.TIC7383_32.nno_Mc:l, in which an additional alanine codon is inserted immediately after the initial methionine codon and comprising deletion of the codons corresponding to amino acid positions 964 to 969 with respect to TIC7383 and used for expression in plant cells. The SEC. ID. #111 is the amino acid sequence of the protein CRBREIa.TIC7383_32.nno_Mc:l, in which an additional alanine amino acid is inserted immediately after the initial methionine and comprises deletion of amino acids 964 to 969 with respect to TIC7383. The SEC. ID. #112 is a synthetic coding sequence, GOI-TIC10743.nno_Mc:l, which encodes a chimeric protein GOI-TIC10743.nno_Mc:l composed of domains one and two of TIC7383 and domain three of TIC7042. The SEC. ID. #113 is the amino acid sequence of chimeric protein GOITIC10743.nno_Mc:l. The SEC. ID. #114 is a synthetic coding sequence, GOI-TIC10744.nno_Mc:l, which encodes a chimeric protein GOI-TIC10744.nno_Mc:l composed of domains one and two of TIC7383 and domain three of TIC7381. The SEC. ID. #115 is the amino acid sequence of chimeric protein GOITIC10744.nno_Mc:l. The SEC. ID. #116 is a synthetic coding sequence, GOI-TIC10745.nno_Mc:l, which encodes a chimeric protein GOI-TIC10745.nno_Mc:l composed of domains one and two of TIC7383 and domain three of TIC7382. CQCLLn / LZnZ / E / Yli The SEC. ID. #117 is the amino acid sequence of chimeric protein GOITIC10745.nno_Mc:l. The SEC. ID. #118 is a synthetic coding sequence, GOI-TIC10746.nno_Mc:l, which encodes a chimeric protein GOI-TIC10746.nno_Mc:l composed of domains one and two of TIC7382 and domain three of TIC7383. The SEC. ID. #119 is the amino acid sequence of chimeric protein GOITIC10746.nno_Mc:l. The SEC. ID. #120 is a synthetic coding sequence, GOI-TIC10747.nno_Mc:l, which encodes a chimeric protein GOI-TIC10747.nno_Mc:l composed of domains one and two of TIC7381 and domain three of TIC7383. The SEC. ID. #121 is the amino acid sequence of chimeric protein GOITIC10747.nno_Mc:l. The SEC. ID. #122 is a synthetic coding sequence, GOI-TIC10748.nno_Mc:l, which encodes a chimeric protein GOI-TIC10748.nno_Mc:l composed of domains one and two of TIC7042 and domain three of TIC7383. The SEC. ID. #123 is the amino acid sequence of the chimeric protein GOITIC10748.nno_Mc:l. The SEC. ID. #124 is a synthetic coding sequence, TIC10764NTermExtl, encoding a chimeric protein TIC10764NTermExtl composed of domains one and two of TIC7382 and domain three of TIC7383 that also includes the N-terminal extension peptide derived from TIC7382. The N-terminal extension of TIC7382 comprises amino acids 1 to 51 of the TIC7382 toxin protein and is encoded by the first 153 nucleotides of the TIC7382 coding sequence. The SEC. ID. #125 is the amino acid sequence of the chimeric protein TIC10764NTermExtl. The SEC. ID. #126 is a synthetic coding sequence, TIC10764NTermExt2, encoding a chimeric protein TIC10764NTermExt2 composed of domains one and two of TIC7382 and domain three of TIC7383 that also includes the N-terminal extension peptide derived from TIC7383. The N-terminal extension of TIC7383 comprises amino acids 1 to 53 of the TIC7383 toxin protein and is encoded by the first 159 nucleotides of the TIC7383 coding sequence. The SEC. ID. #127 is the amino acid sequence of the chimeric protein TIC10764NTermExt2. DETAILED DESCRIPTION OF THE INVENTION The problem in the technique of agricultural pest control can be characterized as a need to have new toxin proteins effective against target pests, which present broad-spectrum toxicity against target pest species, which have the ability to be expressed in plants without causing unwanted agronomic problems and that provide an alternative mode of action compared to the current toxins that are used commercially in plants. Classes of novel insecticidal proteins are described, of which TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389 are examples, as well as members of the related family that provide resistance against Coleoptera and Lepidoptera insect pests and, more particularly, against corn chrysomelid pest species. Also described are synthetic coding sequences designed for expression in a plant cell that encode members of the family related to TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382 and TIC7383, along with N-terminal and C-terminal truncation variants and protein chimeras in the TIC7040 class of toxins. Also described are recombinant nucleic acid molecules comprising a promoter operably linked to a coding sequence encoding a toxin protein TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 or TIC7389 or members of the related family. or fragments of these. Reference in the present application to TIC7040, "TIC7040 protein", "TIC7040 protein toxin", "TIC7040 toxin protein", "TIC7040 pesticidal protein", "TIC7040-related toxins" or "TIC7040-related toxin protein" and the like refers to to any novel pesticidal protein or insect inhibitory protein comprising, consisting of, substantially homologous to, similar to, or derived from any insect inhibitory protein or pesticidal protein sequence of TIC7040 (SEQ ID NO: 2) and insect or pesticide inhibitory segments thereof or combinations thereof, conferring activity against Coleoptera pests or Lepidoptera pests, including any protein exhibiting insect inhibitory or pesticide activity if alignment of such protein with TIC7040 produces sequence identity of amino acids of any percentage fraction between about 90 and about 100 percent. Reference in the present application to TIC7040HT, "TIC7040HT protein", "TIC7040HT protein toxin", "TIC7040HT toxin protein", "TIC7040HT pesticidal protein", "TIC7040HT-related toxins" or "TIC7040HT-related toxin protein" and the like to any novel pesticidal protein or insect inhibitory protein comprising, consisting of, substantially homologous to, similar to, or derived from any insect inhibitory protein or pesticidal protein sequence of TIC7040HT (SEQ ID NO: 4) and insect or pesticide inhibitory segments of these or combinations of these, which confer activity against pests of PQCLLn / LZnZ / E / Yli coleopteran or lepidopteran pests, including any protein exhibiting insect-inhibiting or pesticidal activity if alignment of such protein with TIC7040HT produces an amino acid sequence identity of any fraction of a percent between about 90 and about of 100 percent. Reference in the present application to TIC7042, "TIC7042 protein", "TIC7042 protein toxin", "TIC7042 toxin protein", "TIC7042 pesticidal protein", "TIC7042-related toxins" or "TIC7042-related toxin protein" and the like refers to to any novel pesticidal protein or insect inhibitory protein comprising, consisting of, substantially homologous to, similar to, or derived from any insect inhibitory protein or pesticidal protein sequence of TIC7042 (SEQ ID NO: 12) and insect or pesticide inhibitory segments thereof or combinations thereof, conferring activity against Coleoptera pests or Lepidoptera pests, including any protein exhibiting insect inhibitory or pesticide activity if alignment of such protein with TIC7042 produces sequence identity of amino acids of any percentage fraction between about 93 and about 100 percent. Reference in the present application to TIC7381, "TIC7381 protein", "TIC7381 protein toxin", "TIC7381 toxin protein", "TIC7381 pesticide protein", "TIC7381-related toxins" or "TIC7381-related toxin protein" and the like refers to to any novel pesticidal protein or insect inhibitory protein comprising, consisting of, substantially homologous to, similar to, or derived from any insect inhibitory protein or pesticidal protein sequence of TIC7381 (SEQ ID NO: 14) and insect or pesticide inhibitory segments thereof or combinations thereof, conferring activity against Coleoptera pests or Lepidoptera pests, including any protein exhibiting insect inhibitory or pesticide activity if alignment of such protein with TIC7381 produces sequence identity of amino acids of any percentage fraction between about 90 and about 100 percent. Reference in the present application to TIC7382, "TIC7382 protein", "TIC7382 protein toxin", "TIC7382 toxin protein", "TIC7382 pesticidal protein", "TIC7382-related toxins" or "TIC7382-related toxin protein" and the like refers to to any novel pesticidal protein or insect inhibitory protein comprising, consisting of, substantially homologous to, similar to, or derived from any insect inhibitory protein or pesticidal protein sequence of TIC7382 (SEQ ID NO: 16) and insect or pesticide inhibitory segments thereof or combinations thereof, conferring activity against Coleoptera pests or Lepidoptera pests, including any protein exhibiting insect inhibitory or pesticide activity if alignment of such protein with TIC7382 produces sequence identity of CQCLLn / LZnZ / E / Yli amino acids of any percentage fraction between about 93 and about 100 percent. Reference in the present application to ΊΊΟ7383, "TIC7383 protein", "TIC7383 protein toxin", "TIC7383 toxin protein", "TIC7383 pesticidal protein", "TIC7383-related toxins" or "TIC7383-related toxin protein" and the like refers to to any novel pesticidal protein or insect inhibitory protein comprising, consisting of, substantially homologous to, similar to, or derived from any insect inhibitory protein or pesticidal protein sequence of TIC7383 (SEQ ID NO:18) and insect or pesticide inhibitory segments thereof or combinations thereof, conferring activity against Coleoptera pests or Lepidoptera pests, including any protein exhibiting insect inhibitory or pesticide activity if alignment of such protein with TIC7383 produces sequence identity of amino acids of any percentage fraction between about 75 and about 100 percent. Reference in the present application to TIC7386, "TIC7386 protein", "TIC7386 protein toxin", "TIC7386 toxin protein", "TIC7386 pesticide protein", "TIC7386-related toxins" or "TIC7386-related toxin protein" and the like refers to to any novel pesticidal protein or insect inhibitory protein comprising, consisting of, substantially homologous to, similar to, or derived from any insect inhibitory protein or pesticidal protein sequence of TIC7386 (SEQ ID NO:30) and insect or pesticide inhibitory segments thereof or combinations thereof, conferring activity against Coleoptera pests or Lepidoptera pests, including any protein exhibiting insect inhibitory or pesticide activity if alignment of such protein with TIC7386 produces sequence identity of amino acids of any percentage fraction between about 75 and about 100 percent. Reference in this application to TIC7388, “TIC7388 protein”, “TIC7388 protein toxin”, “TIC7388 toxin protein”, “TIC7388 pesticidal protein”, “TIC7388-related toxins” or “TIC7388-related protein toxin” and the like refers to to any novel pesticidal protein or insect inhibitory protein comprising, consisting of, substantially homologous to, similar to, or derived from any insect inhibitory protein or pesticidal protein sequence of TIC7388 (SEQ ID NO:32) and insect-inhibiting or pesticide-inhibiting segments thereof or combinations thereof, which confer activity against coleopteran pests or lepidopteran pests, including any protein exhibiting insect-inhibiting or pesticidal activity if alignment of said protein with TIC7388 produces sequence identity of amino acids of any percentage fraction between about 99 and about 100 percent. CQCLLn / LZnZ / E / Yli Reference in the present application to TIC7389, "TIC7389 protein", "TIC7389 protein toxin", "TIC7389 toxin protein", "TIC7389 pesticidal protein", "TIC7389-related toxins" or "TIC7389-related toxin protein" and the like refers to to any novel pesticidal protein or insect inhibitory protein comprising, consisting of, substantially homologous to, similar to, or derived from any insect inhibitory protein or pesticidal protein sequence of TIC7389 (SEQ ID NO: 34) and insect or pesticide inhibitory segments thereof or combinations thereof, conferring activity against Coleoptera pests or Lepidoptera pests, including any protein exhibiting insect inhibitory or pesticide activity if alignment of such protein with TIC7389 produces sequence identity of amino acids of any percentage fraction between about 90 and about 100 percent. The term "segment" or "fragment" is used in the present application to describe consecutive nucleic acid or amino acid sequences shorter than the complete nucleic acid or amino acid amino acid sequence describing a TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382 protein. , TIC7383, TIC7386, TIC7388 or TIC7389 or a related family member insecticidal protein. In specific embodiments, fragments of a TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 or TIC7389 protein comprising at least about 50 contiguous amino acids, at least about 75 contiguous amino acids, at least about 95 contiguous amino acids, at least about 100 contiguous amino acids, at least about 125 contiguous amino acids, at least about 150 contiguous amino acids, at least about 175 contiguous amino acids, at least about 200 contiguous amino acids, at least about 225 amino acids contiguous, at least about 250 contiguous amino acids, at least about 275 contiguous amino acids, at least about 300 contiguous amino acids, at least about 500 contiguous amino acids, at least about 600 contiguous amino acids, at least about 700 contiguous amino acids, at least about 750 contiguous amino acids, at least about 800 contiguous amino acids, at least about 850 contiguous amino acids, at least about 900 contiguous amino acids, at least about 950 contiguous amino acids, at least about 1000 contiguous amino acids, at least about 1050 contiguous amino acids, at least about 1100 contiguous amino acids, at least about 1150 contiguous amino acids, at least about 1200 contiguous amino acids, at least about 1250 contiguous amino acids, at least about 1300 contiguous amino acids or at least about 1350 contiguous amino acids, or more, of a protein that has insecticidal activity as described herein. In certain embodiments, the invention provides fragments of a protein provided herein, which has the activity of the sequence CQCLLn / LZnZ / E / Yli complete. The methods of producing said fragments from a starting molecule are known in the art. This application also describes a segment or fragment that exhibits insect inhibitory activity if the alignment of said segment or fragment with the corresponding part of the TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 or TIC7389 protein that indicated in the SECs. ID. #2, 4, 12, 14, 16, 18, 20, 30, 32, and 34 yields any fraction of percent between about 75 and about 100 percent amino acid sequence identity between the segment or fragment and the corresponding part of the TIC7383 and TIC7386 proteins or if it produces, respectively, an amino acid sequence identity of any fraction of a percentage between about 90 and about 100 percent between the segment or fragment and the corresponding part of the TIC7040, TIC7040HT proteins, TIC7381 and TIC7389 or if it produces respectively any fraction of an amino acid sequence identity between about 93 and about 100 percent between the segment or fragment and the corresponding part of the TIC7042 and TIC7382 proteins or if it produces respectively amino acid sequence of any percentage fraction between about 99 and about 100 percent between the segment or fragment and the corresponding part of the TIC7388 protein. Reference in this application to the terms "active" or "activity", "pesticide activity" or "pesticide" or "insecticide activity" "insect inhibition" or "insecticide" refers to the efficacy of a toxic agent , as a protein toxin, to inhibit a pest (inhibit growth, feeding, fecundity, or viability), suppress a pest (suppress growth, feeding, fecundity, or viability), control a pest (control infestation control pest feeding activities on a particular crop with an effective amount of the TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, or TIC7389 protein or a related family member insecticidal protein) or destroy a pest (cause morbidity, mortality or reduced fertility). These terms are intended to include the result of delivery of a pesticidally effective amount of a toxic protein to a pest, wherein exposure of the pest to the toxic protein results in morbidity, mortality, reduced fecundity, or stunting. These terms also include repulsion of the pest by the plant, a plant part, a seed, plant cells, or the particular geographic location in which the plant is grown, as a result of delivery of a pesticidally effective amount of the toxic protein. in the plant. In general, pesticidal activity refers to the ability of a toxic protein to effectively inhibit growth, development, viability, feeding behaviour, reproductive behaviour, fecundity or any measurable decrease in adverse effects caused by a insect that feeds on this CQCLLn / LZnZ / E / Yli protein, protein fragment, protein segment, or polynucleotide of a particular target pest, including, but not limited to, insects of the orders Lepidoptera, Coleoptera, or Hemiptera. The toxic protein may be produced in the plant or may be applied to the plant or the environment at the location of the plant. The terms "bioactivity", "effective", "efficient" or variations thereof are also terms that are used interchangeably in the present application to describe the effects of the proteins of the present invention on target insect pests. When provided in the diet of a target pest, a pesticide-effective amount of a toxic agent exhibits pesticidal activity when the toxic agent comes into contact with the pest. A toxic agent may be a pesticidal protein or one or more chemical agents known in the art. The pesticide or insecticidal chemical agents and insecticidal or pesticide protein agents can be used alone or in combination with each other. Chemical agents include, but are not limited to, dsRNA molecules targeting specific genes for suppression in a target pest, organochlorides, organophosphates, carbamates, pyrethroids, neonicotinoids and ryanoids. Protein insecticidal or pesticide agents include the protein toxins set forth in the present application, as well as other proteinaceous toxic agents including those that target lepidopteran and coleopteran pest species, as well as protein toxins used to control other pests. vegetables such as Cry proteins, available in the art for use in the control of homopteran or hemipteran species. Reference to a pest, in particular a pest of a crop plant, is intended to indicate insect pests of crop plants, in particular those controlled by a protein TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386 , TIC7388 or TIC7389 or a related family member insecticidal protein. Reference to a pest may also include plant pests of homopteran and hemipteran insects, as well as nematodes and fungi, when the toxic agents that target these pests are co-located or present in conjunction with a protein TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7388, TIC7389 or insecticidal protein member of the related family or a protein about 75 to about 100 percent identical to TIC7383 and TIC7386 or a protein about 90 to about 100 percent identical to TIC7040, TIC7040HT, TIC7381 and TIC7389 or a protein about 93 to about 100 percent identical to TIC7042, TIC7386 and TIC7382 or a protein about 99 to about 100 percent identical to TIC7388. The proteins TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389 and related family member insecticidal proteins exhibit insecticidal activity against insect pests of Coleoptera and Lepidoptera insect species, including adults, pupae, larvae and neonates. CQCLLn / LZnZ / E / Yli Insects of the order Lepidoptera include, but are not limited to, tracer worms, cutworms, inchworms and heliotines in the family Noctuidae, e.g. e.g., armyworm (Spodoptera frugiperda), beet worm (Spodoptera exigua), African bollworm (Spodoptera exempta), cruciferous bollworm (Mamestra configurate), bollworm (Spodoptera eridania), black cutworm (Agrotis ípsilon) , cabbage looper (Trichopiusia ni), soybean looper (Pseudopiusia indudend), legume caterpillar (Anticarsia gemmataiis), green clover looper (Hypena scabrá), tobacco budworm (HeHothis virescens), roundworm grainworm (Agrotis subterranean), armyworm (Pseudaietia unipuncta), western cutworm (Agrotis orthogonia), borers, leafminers, weaver caterpillars, pyrals, cabbage caterpillars and caterpillars of the family Pyralidae, e.g. e.g., corn rootworm (Ostrinia nubüaiis), orange navel worm (Amyetois transiteiia), corn rootworm (Crambus caliginosellus), grass caterpillar (Herpetogramma licarsisalis), sunflower moth (Homoeosoma eiecteiium), lesser borer of corn (Eiasmopaipus lignosellus), curler moths, corn earworms, seed worms and fruit worms of the family Tortricidae, p. e.g., apple moth (Cydiapomoneiia), cluster spider (Endopiza viteana), oriental peach moth (Graphoiita molesta), sunflower bud moth (Su / eima helianthaná) and many other lepidopterans of economic relevance, e.g. e.g., diamondback moth (Plutella xytosté Ha), pink cotton caterpillar (Pectinophora gossypieiia) and striped lizard (Lymantria dispar). Other lepidopteran insect pests include e.g. e.g., cotton leafworm (Alabama argi Hacea), fruit tree roller (Archips argyrospHa), shoot roller (Archips rosaná) and other species of Archips, (Chito suppressaiis, rice borer or rice piral), rice leaf bender (Cnaphatocrocis medinalis), corn rootworm (Crambus caliginosellus), grass caterpillar (Crambus teterrellus), southwestern corn borer (Diatraea grandiosella), sugarcane stem borer (Diatraea saccharaüs ), spiny bollworm (Earias insulana), spotted bollworm (Earias vittella), bollworm (HeHcoverpa armigera), corn corn earworm (Heíicoverpa zea, also known as soybean bollworm and cotton bollworm), western bean cutworm (Striacosta albicosta), grapevine cluster moth (Lobesia botrana), citrus leaf miner (Phyííocnistis citreíía), cabbage white butterfly (Pieris brassicaé), cabbage whitefly (Pieris rapae, also known as cabbage caterpillar), tobacco cutworm (Spodoptera / tura, also known as gray tobacco worm) and tomato moth (Tuta ABSOLUTA). Insects of the order Coleoptera include, but are not limited to, Agriotes spp., Anthonomus spp., Atomaria Hnearis, Chaetocnema tibialis, Cosmopolitas spp., CurcuHo spp., Dermestes spp., Diabrotica spp., EpUachna spp., Eremnus spp. ., Leptinotarsa ​​decemüneata, Lissorhoptrus spp., Metotontha spp., OrycaephHus spp., Otiorhynchus spp., Ph / yctinus spp., PopiHia CQCLLn / LZnZ / E / Yli spp., Psyllíodes spp., Rhizopertha spp., Scarabeidae, SítophHus spp., Sítotroga spp., Tenebrío spp., TríboHum spp. and Trogoderma spp, particularly when the pest is western corn rootworm (Diabrotica virgifera, WCR), northern corn rootworm (Diabrotica barberi, NCR). ), Mexican corn rootworm (Diabrotica virgifera zeae, MCR), Brazilian corn rootworm (Diabrotica baiteata, BZR), corn rootworm southern corn (Diabrotica undecimpunctata howardü, SCR), doryphora (Leptinotarsa ​​decemiineata, CPB), a Brazilian corn rootworm complex (BCR, with Diabrotica viriduia and Diabrotica speciosa ), aphid beetle (Phyiiotreta cruciferae), banded cruciferous flea (Phyiiotreta strioiata) and jumping flea (Phyiiotreta pusiHa). Insects of the order Hemiptera include, but are not limited to, bugs of the family Pentatomidae: green bugs of the genus Chinavia (Chinavia hiiaris, Chinavia marginata and Chinavia pensyivanica), bugs of the genus Chiorochroa (Chiorochroa granulóse, Chiorochroa kanei, Chiorochroa Hgata, Chiorochroa linéate, Chiorochroa opuntiae, Chiorochroa persimilis, Chiorochroa rossiana, Chiorochroa sayi, Chiorochroa uhleri, Chiorochroa belfragii, Chiorochroa faceta, Chiorochroa osborni, Chiorochroa saucia and Chiorochroa senilis), southern green stink bug (Nezara viriduia), bed bugs of the genus Ed essa (meditative Edessa , Edessa bifida and Edessa florida), the brown bug (Euschistus heros), bed bugs of the genus Euschistus (Euschistus acuminatus, Euschistus biformis, Euschistus conspersus, Euschistus crenator, Euschistus eggiestoni, Euschistus ictericus, Euschistus inflatus, Euschistus iatimarginatus, Euschistus obscures, Eu schistus poiitus , Euschistus quadrator, Euschistus sevus, Euschistus strenuous, Euschistus tristigmus and Euschistus variolarius), brown marbled bug (Haiyomorpha haiys), red-shouldered bug (Thyanta accerra), bugs of the genus Thyanta (Thyanta caiceata, Thyanta custator, Thyanta paiiidovirens, Thyanta perditor, Thyanta maculate and Thyanta pseudocasta), the green-bellied stink bug (Dichelops meiacanthus) and other bugs of the genus Dichelops (Dichelops avi / apiresi, Dichelops bicolor, Dichelops dimidatus, Dichelops furcatus, Dichelops furcifrons, Dichelops lobatus, Dichelops miriamae, Dichelops nigrum, Dichelops peruanus, Dichelops phoenix and Dichelops saitensis), alfalfa stink bug (Piezodorus guiidinni), as well as Piezodorus Hturatus, and insects of the Plataspidae family such as the kudzu stink bug (Megacopta cribraria), black plant stink bug (Lygus hesperus) and plant bug ligus (Lygus Uneoiaris). The reference in the present application to an "isolated DNA molecule" or an equivalent term or phrase is intended to indicate that the DNA molecule is present alone or in combination with other compositions, but not in its natural environment. For example, nucleic acid elements such as a coding sequence, intron sequence, untranslated leader sequence, promoter sequence, transcription termination sequence and the like, which occur naturally in the DNA of an organism's genome, are not considered "isolated" CQCLLn / LZnZ / E / Yli as long as the element is found in the organism's genome and at the location where it occurs naturally in the genome. However, each of these elements and subparts of these elements would be "isolated" within the scope of the present description as long as the element is not found in the organism's genome and at the location in which it is naturally found in the genome. . Similarly, a nucleotide sequence encoding an insecticidal protein or any naturally occurring insecticidal variant of such a protein would be an isolated nucleotide sequence as long as the nucleotide sequence was not found in the DNA of the bacteria in which it is naturally found. the sequence that codes for the protein. A synthetic nucleotide sequence encoding the amino acid sequence of the naturally occurring insecticidal protein would be considered isolated for the purposes of the present disclosure. For the purposes of the present description, any transgenic nucleotide sequence, that is, the nucleotide sequence of DNA inserted into the genome of plant or bacterial cells or present in an extrachromosomal vector would be considered an isolated nucleotide sequence, regardless that it is present in the plasmid or a similar structure used to transform cells, within the genome of the plant or bacteria or present in detectable quantities in tissues, progeny, biological samples or basic products derived from the plant or bacteria. As further described herein, an open reading frame (ORF) encoding TIC7040 (SEQ ID NO:1) was discovered in DNA obtained from BrevibaciHus laterosporus strain DSC005019, which encodes the protein toxin that appears as SEC. ID. 2. Following amplification with primers designed from the TIC7040 ORF, a slightly longer coding sequence was amplified with DNA obtained from BrevibaciHus laterosporus strain DSC005019, which is indicated herein as TIC7040HT (SEQ ID . no. 3), which encodes the protein presented as SEC. ID. #4. Bioassays with microbial host cell-derived protein TIC7040HT demonstrated activity against coleopteran pests western corn lacewing (Diabrotica virgifera virgifera, WCR), Cry3Bb-resistant western corn lacewing (Diabrotica virgifera virgifera, WCRHP, by its acronym in English), northern corn lacewing (Diabrotica barberi, NCR), southern corn lacewing (Diabrotica undecimpunctata howardü, SCR) and doryphora (Leptinotarsa ​​decemiineata, CPB), as well as the lepidopteran insect pests corn earworm corn (Heiicoverpa zea (CEW), also known as soybean earworm and cotton bollworm), diamondback moth (Plutella xylostella, DBM), corn kernel (Ostrinia nubHaiis, ECB), armyworm (Spodoptera frugiperda, FAW), soybean looper (Pseudopiusia inciudes, SBL), corn borer ( Diatraea grandioseiia, SWCB) and legume caterpillar (Anticarsia CQCLLn / LZnZ / E / Yli gemmatalis, VBC). As further described herein, an ORF encoding TIC7042 (SEQ ID NO:11) was discovered in DNA obtained from Brevibacillus laterosporus strain DSC005973, which encodes the protein toxin reported as SEQ. ID. #12. Bioassays with microbial host cell-derived protein TIC7042 demonstrated activity against Coleopteran pests WCR, WCRHP, NCR, SCR, and CPB and Lepidopteran pests BCW, CEW, DBM, FAW, SBL, and VBC. As further described herein, an ORF encoding TIC7381 (SEQ ID NO:13) was discovered in DNA obtained from Brevibacillus laterosporus strain DSC006713, which encodes the protein toxin reported as SEQ. ID. #14. Bioassays with microbial host cell-derived protein TIC7381 demonstrated activity against Coleopteran pests WCR, WCRHP, NCR, SCR, and CPB and Lepidopteran pests CEW, DBM, ECB, FAW, SBL, SWCB, and VBC. As further described herein, an ORF encoding TIC7382 (SEQ ID NO:15) was discovered in DNA obtained from Brevibacillus laterosporus strain DSC007657, which encodes the protein toxin reported as SEQ. ID. #16. Bioassays with microbial host cell-derived protein TIC7382 demonstrated activity against coleopteran pests WCR, WCRHP, NCR, SCR, and CPB and lepidopteran pests DBM, ECB, SBL, SWCB, and VBC. As further described herein, an ORF encoding TIC7383 (SEQ ID NO:17) was discovered in DNA obtained from Brevibacillus laterosporus strain DSC008106, which encodes the protein toxin reported as SEQ. ID. #18. Bioassays with microbial host cell-derived protein TIC7383 demonstrated activity against coleopteran pests WCR, WCRHP, NCR, SCR, and CPB and lepidopteran pests CEW, DBM, ECB, and VBC. As further described herein, OFRs encoding TIC7386 (SEQ ID NO: 29), TIC7388 (SEQ ID NO: 31) and TIC7389 (SEQ ID NO: 33) were discovered in DNA obtained from Brevibacillus laterosporus strains DSC007651, DSC007962 and DSC006878, respectively, and encoding the proteins included herein as SEQ. ID. No. 30, SEC. ID. No. 32 and SEC. ID. #34 Bioassays with microbial host cell-derived TIC7389 protein demonstrated activity against the lepidopteran insect pest SBL and the coleopteran pests WCR and CPB. As further described herein, tryptic and chymotryptic digests of TIC7040HT, as well as tryptic digests of TIC7383, retained activity against WCR, relative to full-length TIC7040HT and TIC7383. Likewise, truncations of TIC7040HT CQCLLn / LZnZ / E / Yli and TIC7383 retained activity and, in some cases, increased activity against WCR and CPB, relative to full-length TIC7040HT and TIC7383. Also described herein are chimeric toxins composed of domains derived from TIC7381, TIC7382, TIC7383 and TIC7042. The chimeric toxin TIC10743 (SEQ ID NO: 113, encoded by SEQ ID NO: 112) is composed of domains one and two of TIC7383 and domain three of TIC7042. The chimeric toxin TIC10744 (SEQ ID NO: 115, encoded by SEQ ID NO: 114) is composed of domains one and two of TIC7383 and domain three of TIC7381. The chimeric toxin TIC10745 (SEQ ID NO: 117, encoded by SEQ ID NO: 116) is composed of domains one and two of TIC7383 and domain three of TIC7382. The chimeric toxin TIC10746 (SEQ ID NO: 119, encoded by SEQ ID NO: 118) is composed of domains one and two of TIC7382 and domain three of TIC7383. The chimeric toxin TIC10747 (SEQ ID NO: 121, encoded by SEQ ID NO: 120) is composed of domains one and two of TIC7381 and domain three of TIC7383. The chimeric toxin TIC10748 (SEQ ID NO: 123, encoded by SEQ ID NO: 122) is composed of domains one and two of TIC7042 and domain three of TIC7383. The chimeric toxin TIC10746NTermExtl (SEQ ID NO: 125, encoded by SEQ ID NO: 124) is composed of domains one and two of TIC7382, domain three of TIC7383 and the N-terminal extension of TIC7382 . The N-terminal extension of TIC7382 comprises amino acids 1 to 51 of the TIC7382 toxin protein and is encoded by the first 153 nucleotides of the TIC7382 coding sequence. The chimeric toxin TIC10746NTermExt2 (SEQ ID NO: 127, encoded by SEQ ID NO: 126) is composed of domains one and two of TIC7382, domain three of TIC7383 and the N-terminal extension of TIC7383 . The N-terminal extension of TIC7383 comprises amino acids 1 to 53 of the TIC7383 toxin protein and is encoded by the first 159 nucleotides of the TIC7383 coding sequence. For expression in plant cells, TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382 or TIC7383 or variants, truncation variants or chimeras thereof can be expressed such that they reside in the cytosol or target various organelles of the plant cell. For example, targeting a protein to the chloroplast can result in higher levels of protein expressed in a transgenic plant, while avoiding inactivation phenotypes. Targeting may also result in an increase in the effectiveness of pest resistance in the transgenic event. A target peptide or transit peptide is a short peptide chain (3 to 70 amino acids in length) that directs the transport of a protein to a specific region in the cell, including the nucleus, mitochondria, endoplasmic reticulum (ER), the chloroplast, the apoplast, the peroxisome and the plasma membrane. Some target peptides are cleaved from the protein by signal peptidases upon transport of the proteins. For targeting to the chloroplast, proteins contain transit peptides of about 40 to 50 amino acids. HE Descriptions of the use of chloroplast transit peptides can be accessed by CQCLLn / LZnZ / E / Yli in US Patent Nos. 5,188,642 and 5,728,925. Many proteins located in the chloroplast are expressed from nuclear genes as precursors and are targeted to the chloroplast by a chloroplast transit peptide (CTP). Examples of such isolated chloroplast proteins include, but are not limited to, those associated with the small subunit (SSU) of ribulose-l,5,-bisphosphate carboxylase, ferredoxin, ferredoxin oxidoreductase, the scavenger complex. lumen protein I and protein II, thioredoxin F, enolpyruvyl shikimate phosphate synthase (EPSPS) and the transit peptides described in US Patent No. 7,193,133. It has been shown in vivo and in vitro that non-chloroplast proteins can be targeted to the chloroplast using protein fusions with a heterologous CTP and that the CTP is sufficient to target a protein to the chloroplast. It has been shown that incorporation of a transit peptide into the appropriate chloroplast, such as the Arabidopsis thah'ana EPSPS CTP (CTP2) (see Klee et al., Mol. Gen. Genet. 210:437-442, 1987) or the Petunia hybrida EPSPS CTP (CTP4) (refer to della-Cioppa et al., Proc. Nati. Acad. Sci. USA 83:6873-6877, 1986) directs heterologous EPSPS protein sequences to the chloroplast in transgenic plants (refer to US Patent Nos. 5,627,061; 5,633,435 and 5,312,910; and EP 0218571; EP 189707; EP 508909 and EP 924299). To target TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382 and TIC7383 and variants, truncation variants and chimeras thereof to the chloroplast, a sequence encoding a 5' chloroplast transit peptide operably linked and in frame with a sequence synthetic coding that encodes the proteins TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382 and TIC7383 or variants, truncation variants or chimeras thereof, designed for optimal expression in plant cells. The creation of additional toxin protein sequences related to TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389 is contemplated, using the naturally occurring amino acid sequence of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 , TIC7386, TIC7388 and TIC7389, to create novel proteins with novel properties. The toxin proteins TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389 can be aligned with other proteins similar to TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC 7386, TIC7388 and TIC7389, to combine differences to amino acid sequence level into novel amino acid sequence variants and make appropriate changes to the recombinant nucleic acid sequence encoding the variants. The present description additionally contemplates the in planta modification of improved variants of the protein toxin classes TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389, using various gene editing methods known in the art. PQCLLn / LZnZ / E / Yli technique. These technologies used for genome editing include, but are not limited to, ZFN (zinc finger nuclease) systems, meganucleases, TALEN (transcription activator-like effector nucleases), and CRISPR (clustered regularly spaced short palindromic repeats) / Cas (associated with CRISPR). These genome editing methods can be used to alter the coding sequence of the transformed toxin protein within a plant cell into a different toxin coding sequence. Specifically, these methods alter one or more codons in the toxin coding sequence to modify a new protein amino acid sequence. Alternatively, a fragment in the coding sequence is replaced or deleted or additional DNA fragments are inserted into the coding sequence to create a new toxin coding sequence. The new coding sequence may encode a toxin protein with new properties, such as increased activity or spectrum against insect pests, in addition to providing activity against an insect pest species in which resistance has developed against the original insect toxin protein. The plant cell comprising the gene-edited toxin coding sequence can be used in methods known in the art to generate whole plants that express the novel toxin protein. It is also contemplated that fragments of the TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389 proteins or protein variants thereof may be truncated forms, in which one or more amino acids are removed from the N terminus, the C terminus, the middle part of the protein or combinations of these with insect inhibitory activity. These fragments may be synthetic or naturally occurring variants of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389 or protein variants thereof, but must retain the insect inhibitory activity of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389. Proteins resembling TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389 can be identified by comparing them with each other using various computer algorithms known in the art. For example, the amino acid sequence identities of proteins related to TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 can be analyzed using a Clustal W alignment with the following predefined parameters: weight matrix: blosum , gap opening penalty: 10.0, gap extension penalty: 0.05, hydrophilic gaps: on, hydrophilic residues: GPSNDQERK, residue-specific gap penalties: on (Thompson, et al. (1994) Nucleic Acids Research, 22 :4673-4680). Percent amino acid identity is further calculated by the product of 100% multiplied by (amino acid identities / length of target protein). There are also other alignment algorithms CQCLLn / LZnZ / E / Yli available in the art that provide results similar to those obtained with a Clustal W alignment. A protein that exhibits insect inhibitory activity against a lepidopteran or coleopteran insect species is indicated to be related to TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389 if the alignment of said queried protein with TIC7383 or TIC7386 presents at least 75% to about 100% amino acid identity over the entire length of the query protein with about 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83 %, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 100% amino acid identity (or any fraction of a percentage in this range) between the target and query protein or if the alignment of said query protein with TIC7040HT, TIC7381 or TIC7389 has at least 90% to about 100% amino acid identity over the entire length of the query protein with about 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, 100% amino acid sequence identity ( or any fraction of a percentage in this range) between the target and query protein or if the alignment of said query protein with TIC7042 or TIC7382 presents at least 93% to about 100% amino acid identity over the entire length of the query protein with about 93%, 94%, 95%, 96%, 97%, 98%, 99%, 100% amino acid sequence identity (or any percentage fraction in this range) between the target and query protein or if the Alignment of said query protein with TIC7040HT, TIC7381 or TIC7388 presents at least 99% to about 100% amino acid identity over the entire length of the query protein (or any fraction of a percentage in this range) between the target and query protein . The protein examples TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 were aligned to each other using a Clustal W algorithm. A pairwise matrix of percentage amino acid sequence identity was created for each of the full-length proteins, as indicated in Table 1. The number of identical amino acids between two sequences is indicated in parentheses. CQCLLn / LZnZ / E / Yli > α c h c Table 1. o o Paired array presentation of protein examples TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383.0 TIC7386,TIC7388vTIC7389. Toxin TIC7042 SEC. ID. No. 12 TIC7386 SEC. ID. ηθ30 TIC7388 SEC. ID. η.® 32 TIC7382 SEC. ID. No. 16 TIC7040 SEC. ID. #2 TIC7040HT SEC. ID. No. 4 TIC7381 SEC. ID. No. 14 TIC7389 SEC. ID. No. 34 TIC7383 SEC. ID. No. 18 TIC7042 SEC. ID. #12 - 99.1 (1254) 92.3 (1169) 87.8 (mi) 85.7 (1085) 86.3 (1093) 86.7 (1097) 86.7 (1098) 73.3 (928) TIC7386 SEC. ID. #30 98 (1254) - 91.5 (1170) 86.7 (1109) 85.1 (1089) 85.7 (1096) 86 (1100) 86.1 (1101) 72.6 (928) TIC7388 SEC. ID. #32 92.1 (1169) 92.2 (1170) - 93.7 (1189) 88.8 (1127) 89.4 (1135) 89.8 (1140) 89.9 (1141) 76.1 (966) TIC7382 SEC. ID. ηθ 16 89.2 (mi) 89 (1109) 95.4 (1189) - 90.6 (1129) 91.4 (1139) 91.2 (1136) 91.5 (1140) 76.2 (949) TIC7040 SEC. ID. #2 86.2 (1085) 86.5 (1089) 89.5 (1127) 89.7 (1129) - 99.9 (1258) 98.5 (1240) 99 (1247) 76.6 (965) TIC7040HT SEC. ID. #4 84.4 (1093) 84.6 (1096) 87.6 (1135) 88 (1139) 97.1 (1258) 96.6 (1251) 97.2 (1259) 74.8 (969) TIC7381 SEC. ID. #14 86.4 (1097) 86.7 (1100) 89.8 (1140) 89.5 (1136) 97.7 (1240) 98.6 (1251) - 99.5 (1263) 76.5 (971) TIC7389 SEC. ID. #34 83.2 (1098) 83.5 (1101) 86.5 (1141) 86.4 (1140) 94.5 (1247) 95.5 (1259) 95.8 (1263) - 73.9 (975) TIC7383 SEC. ID. #18 73.9 (928) 73.9 (928) 76.9 (966) 75.6 (949) 76.8 (965) 77.1 (969) 77.3 (971) 77.6 (975) - In addition to percent identity, proteins TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 may also be related by backbone structure (conserved amino acid motifs), length (about 1243 to about 1259 amino acids) and other characteristics. Bioinformatics analysis suggests that TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 belong to the Cry43 protein family. Table 2 shows the characteristics of the TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389 proteins. CQCLLn / LZnZ / E / Yli > α r c h c Table 2. Selected features of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389 proteins v related family member proteins. Protein Molecular weight (in Daltons) Length of amino acids Isoelectric point Charge at dH 7.0 Quantity of very basic amino acids 21.27 1295 5.8643 14.0 161 156 636 659 TIC7040_4 75400.92 671 7.0053 2.5 68 61 333 338 TIC7040_5 67268.98 600 7.5498 4.0 61 53 303 297 TIC7040.6 74075.56 660 7.0051 2.5 67 60 332 338 TIC7040HT_Tryp 65150.72 582 8.1625 5.5 59 50 294 288 TIC7040HT_Chymo 66845.58 597 7.8790 4.5 59 51 302 295 CR-BREIa.TIC7040_l.nno_Mc:l 71805.04 640 6.7230 1.0 62 57 325 315 CR-BREIa.TIC7040_ll.nno_Mc:l 65281.91 583 8.1625 5.5 59 50 295 288 CR-BREIa.TIC7040_12.nno_Mc:2 74125.45 660 6.5260 1.5 59 54 311 300 TIC7042 143469.54 1266 6.1143 9.0 158 148 617 649 CR- BREIa.TIC7042_l.nno_Mc:l 71715.51 637 6.6825 1.0 62 56 312 325 CR-BREIa.TIC7042_2.nno_Mc:l 73986.03 657 6.9127 2.5 67 59 319 338 TIC7381 143793.24 1269 6.2077 7.0 162 150 626 643 CR-BREIa.TIC7381_l.nno_Mc:l 143850.30 1270 6.2077 7.0 162 150 627 643 CR-BREIa.TIC7381_2.nno_Mc:l 73892.21 659 6.5260 0.0 64 60 331 328 CR-BREIa.TIC7381_3.nno_Mc:l 6 8253.10 611 6.8814 1.5 59 54 312 299 TIC7382 140890.86 1246 5.7572 13.0 149 147 614 632 CR-BREIa.TIC7382_l.nno_Mc:l 140961.94 1247 5.7572 13.0 149 147 615 632 CR-BREIa.TIC7382_2.nno_Mc:l 73858.00 660 6.6112 0.5 63 58 329 331 CR-BREIa.TIC7382_3.nno_Mc:l 67924.61 610 6.9577 2.0 58 52 310 300 TIC7383 142470.64 1256 5.5492 17.5 151 152 627 629 TIC7383_2 140903.05 1243 5.5471 -17.5 150 151 626 617 TIC7383.3 74526 .97 659 5.7950 3.0 61 61 343 316 Protein Molecular weight (in Daltons) Length of amino acids Isoelectric point Charge at PH7.0 Number of basic muv amino acids 0 Number of acidic muv amino acids Number of hydrophobic amino acids Number of polar amino acids TIC7383_4 76846.56 679 5.9941 -2.5 66 65 350 329 TIC7383_5 72959.38 646 5.7903 3.0 60 60 342 304 TIC7383_6 75278.97 666 5.9913 2.5 65 64 349 317 nC7383_Tryp 69242.24 614 5.822 5 2.5 57 57 326 288 CR-BREIa.TIC7383_l.nno_Mc:l 142541.72 1257 5.5492 17.5 151 152 628 629 CR-BREIa.TIC7383_7. nno_Mc:l 69545.62 617 5.8225 2.5 57 57 328 289 CR-BREIa.TIC7383_8.nno_Mc:l 74772.20 662 5.7950 3.0 61 61 344 318 CR-BREIa.TIC7383_9.nno_Mc: l 75669.20 669 5.5878 4.0 62 63 347 322 CR-BREIa.TIC7383_19 .nno_Mc:l 74030.53 655 5.5815 4.0 61 62 345 310 CR-BREIa.TIC7383_20.nno_Mc:l 73133.53 648 5.7903 3.0 60 60 342 306 CR-BREIa.TIC7383_21.nno _Mc:l 68648.63 610 6.0997 1.5 56 55 325 285 CR-BREIa. TIC7383_22.nno_Mc:l 69474.54 616 5.8225 -2.5 57 57 327 289 CR-BREIa.TIC7383_23.nno_Mc:l 68577.55 609 6.0997 1.5 56 55 324 285 CR-BREIa.TIC73 83_24.rmo_Mc:2 66643.51 590 6.6807 0.5 55 52 315 275 CR- BREIa.TIC7383_25.nno_Mc:3 64647.09 569 6.3851 0.5 54 52 299 270 CR-BREIa.TIC7383_26.nno_Mc:l 62376.52 549 6.6802 0.5 54 51 287 262 CR-BREIa .TIC7383_27.nno_Mc:l 68417.42 607 6.0997 1.5 56 55 324 283 CR-BREIa.TIC7383_28.nno_Mc:l 72902.33 645 5.7903 -3.0 60 60 341 304 CR-BREIa.TIC7383_29.nno_Mc:l 108909.43 964 5.0905 -17.0 104 112 489 475 CR-BREIa.TIC7383_30.nno_Mc:l 142342.42 1257 141715.7 1 1251 5.3252 -21.5 146 151 628 623 TIC7386 144952.03 1279 6.1338 9.0 161 150 621 658 TIC7388 143562.87 1269 6.0794 -9.5 157 148 629 640 TIC7389 149398.97 1319 5.6940 -17.5 162 160 652 667 GOI-TIC10743,nno_Mc:l 69704.53 617 6.0297 2.0 57 56 314 303 GOI-TIC10744.nno_Mc:l 69405.21 616 6.0308 -2.0 57 56 317 299 GOI-TIC10745.nno_Mc:l 69732.59 617 6.2812 1.0 58 56 314 303 GOI-TIC10746.nno_Mc:l 67737.64 610 6.6433 0.5 57 53 324 286 GOI-TIC10747. nno_Mc:l 68393.51 612 6.8012 1.0 59 58 323 289 GOI-TIC10748, nno_Mc:l 68118.77 609 6.7284 1.0 59 54 312 297 TIC10746NTermExtl 73599.95 659 6.3342 1.0 62 59 342 317 TIC10746NTermExt2 73790.14 661 6.3342 1.0 62 59 342 319 As further described in the examples in the present application, recombinant nucleic acid molecule sequences encoding TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382 and TIC7383 and variants, truncation variants and chimeras thereof were designed for use in plants. Examples of recombinant nucleic acid molecule sequences subjected to plant optimization, designed for use in plants, are presented in Table 8 of Example 5, along with the corresponding protein and nucleotide sequences, description and modifications. Expression cassettes and vectors can be constructed with these recombinant nucleic acid molecule sequences and introduced into corn, soybean, cotton or other plant cells, according to transformation methods and techniques known in the art. For example, Agrobacteríum-mediated transformation is described in US Patent Application Publications No. 2009 / 0138985A1 (soybean), 2008 / 0280361A1 (soybean), 2009 / 0142837A1 (corn), 2008 / 0282432 (cotton), 2008 / 0256667 (cotton), 2003 / 0110531 (wheat), 2001 / 0042257 Al (sugar beet), US Patent Nos. 5,750,871 (cane), 7,026,528 (wheat) and 6,365,807 (rice), as well as in Arencibia et al. (1998) Transgenic Res. 7:213-222 (sugarcane), all of which are incorporated herein in their entirety by this reference. The transformed cells can be regenerated into transformed plants expressing TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382 or TIC7383. To analyze the pesticide activity, bioassays are carried out with larvae of lepidopteran pests, using plant leaf discs obtained from transformed plants, as described in the examples. To analyze the pesticide activity against Coleoptera pests, transformed plants of the Roy Fi generation are used in rootworm assays, as described in the examples. To analyze the pesticide activity against hemipteran pests, pods, ears or leaves of transformed plants are used in the test, whether they are from tissue extracted from the plant or that have remained on the plant, as described in the examples. As an alternative to traditional transformation methods, a DNA sequence, such as a transgene, one or more expression cassettes, etc., can be inserted or integrated into a specific point or locus in the genome of a plant or plant cell, using point-directed integration. Therefore, the recombinant DNA construct(s) and molecule(s) of the present disclosure may include a donor template sequence with at least one transgene, expression cassette or other DNA sequence for insertion into the plant genome or plant cell. This donor template for point-directed integration may additionally include one or two homology groups on the sides of an insertion sequence (i.e., the sequence, transgene, cassette, etc., that is desired to be inserted into the plant genome). . The recombinant DNA construct(s) of the present disclosure may further comprise one or more expression cassettes encoding a point-specific nuclease and / or any protein to perform point-directed integration. This nuclease expression cassette(s) may be present CQCLLn / LZnZ / E / Yli in the same molecule or vector as the donor template (in cis) or in a separate molecule or vector (in trans). Various methods of point-directed integration are known in the art, involving different proteins (or protein complexes and / or guide RNA) that cleave genomic DNA to produce a cut or double-strand break (DSB). English) at a desired genomic locus or point. As is understood in the art, during the DSB repair process that is introduced by the nuclease enzyme, the donor template DNA may become integrated into the genome at the point of the cut or DSB. The presence of the homology group(s) in the donor template can promote the adoption and targeting of the insertion sequence in the plant genome during the repair process, through homologous recombination, although an insertion event can occur by joining non-heterologous extremes (NHEJ). Examples of point-specific nucleases that can be used include zinc finger nucleases, natural or modified meganucleases, TALEendonucleases, and RNA-guided endonucleases (e.g., Cas9 or Cpfl). For methods with RNA-guided site-specific nucleases (e.g., Cas9 or Cpfl), the recombinant DNA construct(s) will also comprise a sequence encoding one or more guide RNAs to direct the nuclease to the desired site in the genome. vegetable. Compositions of recombinant nucleic acid molecules encoding TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389 or related family member insecticidal proteins are contemplated. For example, TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389 or related family member insecticidal proteins can be expressed with recombinant DNA constructs in which a polynucleotide molecule with an OFR encoding the protein is is operatively linked to gene expression elements, such as a promoter and any other regulatory element necessary for expression in the system for which the construction is intended. Non-limiting examples include a plant functional promoter operably linked to the coding sequences of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389 or the related family member insecticidal protein, for expression of the protein in plants or a functional Bt promoter operably linked to coding sequences of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389 or the related family member insecticidal protein, for expression of the protein in a bacteria Btu another species Bacillus. Other elements may be operatively linked to the coding sequences of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389 or the insecticidal protein member of the related family, including, but not limited to, enhancers , introns, non-translational leaders, encoded protein immobilization tags (His tag), shuttle peptides (i.e., plastid transit peptides, CQCLLn / LZnZ / E / Yli signal peptides), polypeptide sequences for post-translational modification enzymes, ribosome binding sites and ¡RNA targeting sites. Examples of recombinant polynucleotide molecules provided herein include, but are not limited to, a heterologous promoter operably linked to a polynucleotide, such as SEC. ID. No. 1, SEC. ID. #3, SEC. ID. No. 5, SEC. ID. No. 7, SEC. ID. No. 9, SEC. ID. No. 11, SEC. ID. No. 13, SEC. ID. No. 15, SEC. ID. No. 17, SEC. ID. No. 19, SEC. ID. No. 21, SEC. ID. No. 23, SEC. ID. No. 25, SEC. ID. No. 27, SEC. ID. No. 29, SEC. ID. No. 31, SEC. ID. No. 33, SEC. ID. No. 35, SEC. ID. No. 36, SEQ ID. No. 37, SEC. ID. No. 38, SEC. ID. No. 39, SEC. ID. No. 40, SEC. ID. No. 41, SEC. ID. No. 42, SEQ ID. No. 44, SEC. ID. No. 45, SEC. ID. No. 47, SEC. ID. No. 49, SEC. ID. No. 51, SEC. ID. No. 52, SEQ ID. No. 54, SEC. ID. No. 56, SEC. ID. No. 58, SEC. ID. No. 60, SEC. ID. No. 62, SEC. ID. No. 64, SEQ ID. No. 66, SEC. ID. No. 68, SEC. ID. No. 70, SEC. ID. No. 72, SEC. ID. No. 74, SEC. ID. No. 76, SEQ ID. No. 78, SEC. ID. No. 80, SEC. ID. No. 82, SEC. ID. No. 84, SEC. ID. No. 86, SEC. ID. No. 88, SEQ.ID. No. 90, SEC. ID. No. 92, SEC. ID. No. 94, SEC. ID. No. 96, SEC. ID. No. 98, SEC. ID. No. 100, SEC. ID. No. 102, SEC. ID. No. 104, SEC. ID. No. 106, SEC. ID. No. 108, SEC. ID. No. 110, SEC. ID. No. 112, SEC. ID. No. 114, SEC. ID. No. 116, SEC. ID. No. 118, SEC. ID. No. 120, SEC. ID. No. 122, SEQ ID NO: 124 and SEQ. ID. No. 126 which encodes a polypeptide or a protein with the amino acid sequence indicated in SEQ. ID. No. 2, SEC. ID. No. 4, SEC. ID. No. 6, SEC. ID. No. 8, SEC. ID. No. 10, SEC. ID. No. 12, SEC. ID. No. 14, SEC. ID. No. 16, SEC. ID. No. 18, SEC. ID. No. 20, SEC. ID. No. 22, SEC. ID. No. 24, SEC. ID. No. 26, SEC. ID. No. 28, SEC. ID. No. 30, SEC. ID. No. 32,SEC. ID. No. 34, SEC. ID. No. 43, SEC. ID. No. 46, SEC. ID. No. 48, SEC. ID. No. 50, SEC. ID. No. 53,SEC. ID. No. 55, SEC. ID. No. 57, SEC. ID. No. 59, SEC. ID. No. 61, SEC. ID. No. 63, SEC. ID. No. 65, SEC. ID. No. 67, SEC. ID. No. 69, SEC. ID. No. 71, SEC. ID. No. 73, SEC. ID. No. 75, SEC. ID. No. 77, SEC. ID. No. 79, SEC. ID. No. 81, SEC. ID. No. 83, SEC. ID. No. 85, SEC. ID. No. 87, SEC. ID. No. 89,SEC. ID. No. 91, SEC. ID. No. 93, SEC. ID. No. 95, SEC. ID. No. 97, SEC. ID. No. 99, SEC. ID. No. 101, SEC. ID. No. 103, SEC. ID. No. 105, SEC. ID. No. 107, SEC. ID. No. 109, SEC. ID. No. 111, SEC. ID. No. 113, SEC. ID. No. 115, SEC. ID. No. 117, SEC. ID. No. 119, SEC. ID. No. 121, SEC. ID. No. 123, SEC. ID. No. 125 and SEC. ID. No. 127. A heterologous promoter may also be operatively linked to synthetic DNA coding sequences encoding TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, variants, truncation variants and chimeras thereof, targeting or non-targeting. a plastid, as well as TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, variants, truncation variants and chimeras of these non-targeting or related family member insecticidal proteins. Codons of a recombinant nucleic acid molecule encoding proteins described herein may be substituted with synonymous codons (known in the art as a silent substitution). A recombinant DNA construct with a TIC7040 coding sequence, CQCLLn / LZnZ / E / Yli TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389 or related family member insecticidal protein may further comprise a region of DNA encoding one or more insect inhibitory agents that may be configured to be expressed concomitantly or jointly. with a DNA sequence encoding a TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389 or insecticidal protein member of the related family, a protein other than TIC7040, TIC7040HT, TIC7042, TIC7381, TIC738 2, TIC7383, TIC7386, TIC7388, TIC7389 or a related family member insecticidal protein, an insect inhibitory dsRNA molecule or an auxiliary protein. Auxiliary proteins include, but are not limited to, cofactors, enzymes, binding partners or other agents that assist in the effectiveness of an insect inhibitory agent, for example, by contributing to its expression, affecting its stability in plants, optimizing free energy. for oligomerization, increasing its toxicity and its spectrum of activity. An auxiliary protein may facilitate the uptake of one or more insect inhibitory agents, for example, or enhance the toxic effects of the toxic agent. A recombinant DNA construct can be assembled such that all proteins or dsRNA molecules from a promoter are expressed or that each protein or dsRNA molecule is expressed with separate promoter control or some combination of these. TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389 and related family member proteins of the present invention can be expressed from a multiple gene expression system, in which one or more of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389 or related family member proteins are expressed from a common nucleotide segment, which also contains other promoters and open reading frames, depending on the type of selected expression system. For example, a multiple bacterial gene expression system may use a single promoter to derive expression of double or multiple linkage open reading frames from within a single operon (i.e., polycistronic expression). In another example, a multiple plant gene expression system may use multilinker-free expression cassettes, each of which expresses a different protein or other agent, such as one or more dsRNA molecules. Recombinant nucleic acid molecules or recombinant DNA constructs comprising a coding sequence of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389 or related family member protein can be delivered to host cells by vectors. , p. e.g., a plasmid, baculovirus, synthetic chromosome, virion, cosmid, phagemid, phage or other viral vector. Such vectors can be used to achieve transient or stable expression of a coding sequence of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389 or family member protein. related CQCLLn / LZnZ / E / Yli in a host cell or subsequent expression of the encoded polypeptide. An exogenous recombinant polynucleotide or a recombinant DNA construct comprising a protein coding sequence and introduced into a host cell is referred to herein as a "transgene." Provided herein are transgenic bacteria, transgenic plant cells, transgenic plants and parts of transgenic plants containing a recombinant polynucleotide that expresses any one or more of the coding sequences of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389 or related family member protein. The term "bacterial cell" or "bacteria" may include, but is not limited to, a cell of Agrobacterium, Bacillus, Escherichia, Salmonella, Pseudomonas or Rhizobium. The term "plant cell" or "plant" may include, but is not limited to, a dicot cell or a monocot cell. The plants and plant cells contemplated include, but are not limited to, plant cells or plants of alfalfa, banana, barley, bean, broccoli, cabbage, brassica, carrot, tapioca, castor bean, cauliflower, celery, chickpea, bok choy, citrus plant , coconut, coffee, corn, clover, cotton, a cucurbit, cucumber, Douglas fir, eggplant, eucalyptus, flax, garlic, grape, hops, leek, lettuce, bronco pine, millet, melons, walnut, oats, olive, onion , ornamental plants, palm tree, pasture grass, pea, peanut, pepper, pigeonpea, pine, potato, poplar, pumpkin, pine, radish, rapeseed, rice, roots, rye, safflower, shrub, sorghum, southern pine, seed soybean, spinach, pumpkin, strawberry, sugar beet, sugar cane, sunflower, sweet corn, American storax, sweet potato, meadow grass, tea, tobacco, tomato, triticale, lawn grass, watermelon and wheat. In certain embodiments, transgenic plants and transgenic plant parts regenerated from a transgenic plant cell are provided. In certain embodiments, transgenic plants can be obtained from a transgenic seed by cutting, breaking, grinding or other dissociation of the plant part. In certain embodiments, the plant part may be a seed, weevil, leaf, flower, root or any part thereof or a non-regenerative part of a transgenic plant part. As used in this context, a "non-regenerable" part of a transgenic plant part is a part that cannot be induced to form a whole plant or that cannot be induced to form a whole plant capable of sexual reproduction. and / or asexual. In certain embodiments, a non-regenerable part of a plant part is a part of a transgenic seed, weevil, leaf, flower, stem or root. Methods are provided for making transgenic plants comprising insect, coleopteran or lepidopteran inhibitory amounts of a TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389, variant, truncation variant, chimera or member protein. related family. These plants can be prepared by introducing CQCLLn / LZnZ / E / Yli of a recombinant polynucleotide encoding any of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389, variant, truncation variant, chimera or related family member protein provided in the present application in a plant cell and selection of a plant derived from said plant cell that expresses an insect, coleopteran or lepidopteran inhibitory amount of the proteins. Plants can be derived from plant cells by seed, pollen or meristem transformation or regeneration techniques. Methods for transforming plants are known in the art. Also described in the present application are processed plant products, wherein the processed product comprises a detectable amount of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389, variant, truncation variant, chimera or member protein of the related family, an insect-inhibiting segment or fragment thereof, or any separable part thereof. In certain embodiments, the processed product is selected from the group consisting of plant parts, plant biomass, oil, mill, sugar, animal feed, flour, flakes, bran, lint, hulls, processed seed and seed. In certain embodiments, the processed product cannot be regenerated. The plant product may comprise commodities or other commercial products derived from a transgenic plant or transgenic plant part, wherein the commodity or other product can be traced in commercial activity by detecting nucleotide segments or expressed RNA or proteins that encode or comprise identifiable parts of a TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389, variant, truncation variant, chimera or related family member protein. Plants expressing TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389, variant, truncation variant, chimera or related family member protein can be crossed by breeding with transgenic events expressing other toxin proteins and / or or that express other transgenic traits, such as herbicide tolerance genes, yield-conferring genes or pressure tolerance traits and the like, or these traits can be combined into a single vector so that all traits are linked. As further described in the examples, sequences encoding TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382 and TIC7383, variants of TIC7040HT, TIC7042, TIC7381, TIC7382 and TIC7383, truncation variants of TIC7040HT, TIC7042, TIC73 were designed. 81, TIC7382 and TIC7383 and chimeras of TIC7383, TIC7042, TIC7381 and TIC7382 for use in plants and are presented in Table 8 in Example 5. Expression cassettes and vectors can be constructed with these artificial or synthetic nucleotide sequences and introduced into corn, cotton and soybean plant cells, according to transformation methods and techniques known in the art. The transformed cells CQCLLn / LZnZ / E / Yli regenerate in transformed plants that are observed to express TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382 or TIC7383 or variants, truncation variants or chimeras thereof. To analyze the pesticide activity, bioassays are carried out with lepidopteran, coleopteran and hemipteran pests. As further described in the examples, sequences encoding TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, variants, truncation variants, chimeras or related family member proteins and sequences with a considerable percentage of identity with regarding these proteins, using methods known to those skilled in the art, such as polymerase chain reaction (PCR), thermal amplification and hybridization. For example, a protein TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 and variants, truncation variants, chimeras or related family member proteins can be used to produce antibodies that specifically bind to related proteins and can be used to analyze and find other closely related protein members. Additionally, nucleotide sequences encoding TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382 or TIC7383 and variants, truncation variants, chimeras or related family member proteins can be used as probes and primers to analyze and identify other members of the class, using isothermal or thermal cycling hybridization and amplification methods. For example, oligonucleotides derived from sequences indicated as SEC can be used. ID. No. 35, SEC. ID. No. 36, SEC. ID. No. 37, SEC. ID. No. 38, SEC. ID. No. 39, SEC. ID. No. 40, SEC. ID. No. 41, SEC. ID. No. 42, SEC. ID. No. 44, SEC. ID. No. 45, SEC. ID. No. 47, SEC. ID. No. 49, SEC. ID. No. 51, SEC. ID. No. 52, SEC. ID. No. 54, SEC. ID. No. 56, SEC. ID. No. 58, SEQ ID. No. 60, SEC. ID. No. 62, SEC. ID. No. 64, SEC. ID. No. 66, SEC. ID. No. 68, SEC. ID. No. 76, SEQ ID. No. 78, SEC. ID. No. 80, SEC. ID. No. 82, SEC. ID. No. 84, SEC. ID. No. 86, SEC. ID. No. 88, SEQ ID. No. 90, SEC. ID. No. 92, SEC. ID. No. 94, SEC. ID. No. 96, SEC. ID. No. 98, SEC. ID. No. 100, SEC. ID. No. 102, SEC. ID. No. 104, SEC. ID. No. 106, SEC. ID. No. 108, SEC. ID. No. 110, SEQ ID NO:112, SEQ. ID. No. 114, SEC. ID. No. 116, SEC. ID. No. 118, SEC. ID. No. 120, SEC. ID. No. 122, SEC. ID. No. 124 and SEC. ID. No. 126 to determine the presence or absence of a TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382 or TIC7383 protein or related family member protein variants, truncation variants, chimeras or transgenes in a deoxyribonucleic acid sample derived from a basic product. Given the sensitivity of certain nucleic acid detection methods using oligonucleotides, it is anticipated that oligonucleotides derived from the sequences indicated as SEC can be used. ID. No. 35, SEC. ID. No. 36, SEC. ID. No. 37, SEC. ID. No. 38, SEC. ID. No. 39, SEC. ID. No. 40, SEC. ID. No. 41, SEC. ID. No. 42, SEC. ID. No. 44, SEC. ID. No. 45, SEC. ID. No. 47, SEC. ID. No. 49, SEC. ID. No. 51, SEC. ID. No. 52, SEC. CQCLLn / LZnZ / E / Yli ID. No. 54, SEC. ID. No. 56, SEC. ID. No. 58, SEC. ID. No. 60, SEC. ID. No. 62, SEC. ID. No. 64, SEC. ID. No. 66, SEC. ID. No. 68, SEC. ID. No. 76, SEC. ID. No. 78, SEC. ID. No. 80, SEC. ID. No. 82,SEC. ID. No. 84, SEC. ID. No. 86, SEC. ID. No. 88, SEC. ID. No. 90, SEC. ID. No. 92, SEC. ID. No. 94,SEC. ID. No. 96, SEC. ID. No. 98, SEC. ID. No. 100, SEC. ID. No. 102, SEC. ID. No. 104, SEC. ID. #106, SEC. ID. No. 108, SEC. ID. No. 110, SEC. ID. No. 112, SEC. ID. No. 114, SEC. ID. No. 116, SEC. ID. No. 118, SEC. ID. No. 120, SEC. ID. No. 122, SEC. ID. No. 124 and SEC. ID. #126 to detect TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382 or TIC7383, variants, truncation variants or chimeric transgenes thereof in commodities derived from pooled sources in which only a fraction of the commodity is derived from a transgenic plant with any of the SEC. ID. No. 35, SEC. ID. No. 36, SEC. ID. No. 37, SEC. ID. No. 38, SEC. ID. No. 39, SEC. ID. No. 40, SEC. ID. No. 41, SEC. ID. No. 42, SEC. ID. No. 44, SEC. ID. No. 45, SEC. ID. No. 47, SEC. ID. no. 49, SEC. ID. No. 51, SEC. ID. No. 52, SEC. ID. No. 54, SEC. ID. No. 56, SEC. ID. No. 58, SEC. ID# 60, SEC. ID. No. 62, SEC. ID. No. 64, SEC. ID. No. 66, SEC. ID. No. 68, SEC. ID. No. 76, SEC. ID# 78, SEC. ID. No. 80, SEC. ID. No. 82, SEC. ID. No. 84, SEC. ID. No. 86, SEC. ID. No. 88, SEC. ID# 90, SEC. ID. No. 92, SEC. ID. No. 94, SEC. ID. No. 96, SEC. ID. No. 98, SEC. ID. No. 100, SEC. ID. No. 102, SEC. ID. No. 104, SEC. ID. No. 106, SEC. ID. No. 108, SEC. ID. No. 110, SEC. ID. No. 112, SEC. ID. No. 114, SEC. ID. No. 116, SEC. ID. No. 118, SEC. ID. No. 120, SEC. ID. No. 122, SEC. ID. No. 124 or SEC. ID. No. 126. It is further recognized that such oligonucleotides can be used to introduce nucleotide sequence variation in the SECs. ID. No. 35, SEC. ID. No. 36, SEC. ID. No. 37, SEC. ID. No. 38, SEC. ID. No. 39, SEC. ID. No. 40, SEC. ID. No. 41, SEC. ID. No. 42, SEC. ID. no. 44, SEC. ID. No. 45, SEC. ID. No. 47, SEC. ID. No. 49, SEC. ID. No. 51, SEC. ID. No. 52, SEC. ID. no. 54, SEC. ID. No. 56, SEC. ID. No. 58, SEC. ID. No. 60, SEC. ID. No. 62, SEC. ID. No. 64, SEC. ID. no. 66, SEC. ID. No. 68, SEC. ID. No. 76, SEC. ID. No. 78, SEC. ID. No. 80, SEC. ID. No. 82, SEC. ID. no. 84, SEC. ID. No. 86, SEC. ID. No. 88, SEC. ID. No. 90, SEC. ID. No. 92, SEC. ID. No. 94, SEC. ID. no. 96, SEC. ID. No. 98, SEC. ID. No. 100, SEC. ID. No. 102, SEC. ID. No. 104, SEC. ID. No. 106, SEC. ID. No. 108, SEC. ID. No. 110, SEC. ID. No. 112, SEC. ID. No. 114, SEC. ID. No. 116, SEC. ID. No. 118, SEC. ID. No. 120, SEC. ID. No. 122, SEC. ID. No. 124 or SEC. ID. No. 126. Such "mutagenesis" oligonucleotides are useful for identifying TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389 or related family member amino acid sequence variants exhibiting a range of inhibitory activity of insects or varied expression in host cells of transgenic plants. Homologs of nucleotide sequences, e.g. e.g., insecticidal proteins encoded by the nucleotide sequences that hybridize with each or any of the sequences described in the present application under hybridization conditions also form an embodiment of the present invention. The invention also provides a method for detecting a first sequence of CQCLLn / LZnZ / E / Yli nucleotides that hybridize with a second nucleotide sequence, in which the first nucleotide sequence (or its reverse complement sequence) encodes a pesticidal protein or a pesticidal fragment thereof and hybridizes under hybridization conditions rigorous with the second nucleotide sequence. In this case, the second nucleotide sequence may be the nucleotide sequence selected from the group consisting of: SEQ. ID. No. 1, SEC. ID. #3, SEC. ID. no. 5, SEC. ID. No. 7, SEC. ID. No. 9, SEC. ID. No. 11, SEC. ID. No. 13, SEC. ID. No. 15, SEC. ID. #17, SEC. ID. No. 19, SEC. ID. No. 21, SEC. ID. No. 23, SEC. ID. No. 25, SEC. ID. No. 27, SEC. ID. n°29, SEC. ID. No. 31, SEC. ID. No. 33, SEC. ID. No. 35, SEC. ID. No. 36, SEC. ID. No. 37, SEC. ID. #38, SEC. ID. No. 39, SEC. ID. No. 40, SEC. ID. No. 41, SEC. ID. No. 42, SEC. ID. No. 44, SEC. ID. #45, SEC. ID. No. 47, SEC. ID. No. 49, SEC. ID. No. 51, SEC. ID. No. 52, SEC. ID. No. 54, SEC. ID. n°56, SEC. ID. No. 58, SEC. ID. No. 60, SEC. ID. No. 62, SEC. ID. No. 64, SEC. ID. No. 66, SEC. ID. #68, SEC. ID. No. 70, SEC. ID. No. 72, SEC. ID. No. 74, SEC. ID. No. 76, SEC. ID. No. 78, SEC. ID. #80, SEC. ID. No. 82, SEC. ID. No. 84, SEC. ID. No. 86, SEC. ID. No. 88, SEC. ID. No. 90, SEC. ID. #92, SEC. ID. No. 94, SEC. ID. No. 96, SEC. ID. No. 98, SEC. ID. No. 100, SEC. ID. No. 102, SEC. ID. No. 104, SEC. ID. No. 106, SEC. ID. No. 108, SEC. ID. No. 110, SEC. ID. No. 112, SEC. ID. No. 114, SEC. ID. No. 116, SEC. ID. No. 118, SEC. ID. No. 120, SEC. ID. No. 122, SEC. ID. No. 124 and SEC. ID. #126 under stringent hybridization conditions. The nucleotide coding sequences hybridize to each other under appropriate hybridization conditions and the proteins encoded by these nucleotide sequences cross-react with antiserum against any of the other proteins. Stringent hybridization conditions, as defined herein, comprise at least hybridization at 42°C, followed by two washes for five minutes each at room temperature with 2X SSC, 0.1% SDS, followed by two washes for thirty minutes. each at 65°C in 0.5X SSC, 0.1% SDS. Washing at even higher temperatures constitutes even more rigorous conditions, e.g. e.g., hybridization conditions at 68°C, followed by washing at 68°C in 2x SSC with 0.1% SDS. The person skilled in the art will recognize that, due to the redundancy of the genetic code, many other sequences have the capacity to encode proteins related to TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 or TIC7389 and said sequences, to the extent in which they express pesticide proteins in Bacillus strains or in plant cells, are embodiments of the present invention, obviously recognizing that many redundant coding sequences of this type will not hybridize under these conditions with the natural BrevibaciHus sequences that encode TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 or TIC7389. The present application contemplates the use of these and other identification methods known to those skilled in the art to identify coding sequences of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, CQCLLn / LZnZ / E / Yli TIC7389 or related family member proteins and sequences with a considerable percentage of identity with respect to them. Also described in the present application are methods for controlling insects, in particular lepidopteran or coleopteran infestations in crop plants, with TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389 or related family member proteins. These methods may comprise growing a plant with an insect, coleopteran or lepidopteran inhibitory amount of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389, a variant, truncation variant, chimera or member toxin protein of the related family. In certain embodiments, said methods may further comprise any of: (i) applying any composition comprising or encoding TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389. a variant, truncation variant, chimera or toxin protein family member related to a plant or a seed that generates a plant and (i) transform a plant or a plant cell that generates a plant with a polynucleotide that encodes TIC7040, TIC7040HT , TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389, a variant, truncation variant, chimera or related family member toxin protein. Generally, it is contemplated that TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389, the variant, truncation variant or related family member toxin protein may be provided in a composition, provided in a microorganism or provided in a transgenic plant to confer insect inhibitory activity against lepidopteran or coleopteran insects. In certain embodiments, a recombinant nucleic acid molecule of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389, a variant, truncation variant, chimera or related family member toxin protein is the active insecticidal ingredient. of an insect inhibitory composition made by culturing recombinant Bacillus or any other recombinant bacterial cell transformed to express the protein. Said composition can be prepared by dissecting, lyophilization, homogenization, extraction, filtration, centrifugation, sedimentation or concentration of a culture of said recombinant cells that express / produce said recombinant polypeptide. Said process can give rise to a Bacillus or other entomopathogenic cell extract, bacterial cell extract, cell suspension, cell homogenate, cell lysate, cell supernatant, cell filtrate or cell pellet. By obtaining the recombinant polypeptides produced in this way, a composition that includes the recombinant polypeptides can include bacterial cells, bacterial spores and paraspore inclusion bodies and can be formulated for various uses, including as agricultural insect-inhibiting aerosol products or as formulations insect inhibitors in feeding bioassays. CQCLLn / LZnZ / E / Yli In one embodiment, to reduce the likelihood of resistance development, an insect inhibitor composition with TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389, a variant, truncation variant, chimera or family member related may additionally comprise at least one additional polypeptide known to those skilled in the art, which exhibits insect inhibitory activity against the same species of lepidopteran and coleopteran insects, but other than TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389, variant, truncation variant, chimera or related family member toxin protein. Possible additional polypeptides for such a composition include an insect inhibitory protein and an insect inhibitory dsRNA molecule. An example of the use of said ribonucleotide sequences to control insect pests is described in Baum, et al. (US Patent Publication No. 2006 / 0021087 Al). Said additional polypeptide for controlling lepidopteran pests can be selected from the group consisting of an insect inhibitory protein such as, but not limited to, CrylA (US Patent No. 5,880,275), CrylAb, CrylAc, CrylA.105, CrylAe, CrylB ( US Patent Publication 10 / 525,318), CrylC (US Patent No. 6,033,874), CrylD, CrylDa and variants thereof, CrylE, CrylF and CrylA / F chimeras (US Patent Nos. 7,070,982; 6,962,705 and 6,713,063), CrylG, CrylH, Cryll, CrylJ, CrylK, CrylL, Cryl-like chimeras such as, but not limited to, TIC836, TIC860, TIC867, TIC869 and TIC1100 (International Application Publication WO2016 / 061391 (A2)), TIC2160 (International Application Publication WO2016 / 061392(A2)), Cry2A, Cry2Ab (US Patent No. 7,064,249), Cry2Ae, Cry4B, Cry6, Cry7, Cry8, Cry9, Cryl5, Cry43A, Cry43B, Cry51Aal, ET66, TIC400, TIC800, TIC834, TIC1415, Vi p3A, VIP3Ab, VIP3B, AXMI-001, AXMI-002, AXMI-030, AXMI-035, AND AXMI-045 (US Patent Publication 2013-0117884 Al), AXMI-52, AXMI-58, AXMI-88, AXMI-97 , AXMI-102, AXMI-112, AXMI-117, AXMI100 (US Patent Publication 2013-0310543 Al), AXMI-115, AXMI-113, AXMI-005 (US Patent Publication 2013-0104259 Al), AXMI-134 (US Patent Publication 2013-0167264 Al), AXMI-150 (US Patent Publication 20100160231 Al), AXMI-184 (US Patent Publication 2010-0004176 Al), AXMI-196, AXMI-204, AXMI-207, AXMI -209 (U.S. Patent Publication 2011-0030096 Al), AXMI218, AXMI-220 (U.S. Patent Publication 2014-0245491 Al), AXMI-221Z, AXMI-222z, AXMI-223z, AXMI-224z, AXMI-225z (U.S. Patent Publication US Patent Publication 2014-0196175 Al), AXMI-238 (US Patent Publication 2014-0033363 Al), AXMI-270 (US Patent Publication 2014-0223598 Al), AXMI-345 (US Patent Publication 20140373195 Al), AXMI -335 (International Application Publication WO2013 / 134523(A2)), DIG-3 (US Patent Publication 2013-0219570 Al), DIG-5 (US Patent Publication 2010-0317569 Al), DIG-11 (Patent Publication US 2010-0319093 CQCLLn / LZnZ / E / Yli Al), AflP-lA and derivatives thereof (US Patent Publication 2014-0033361 Al), ΑΠΡ-1Β and derivatives thereof (US Patent Publication 2014-0033361 Al), PIP-1APIP-1B (US Patent Publication 2014 -0007292 Al), PSEEN3174 (US Patent Publication 2014-0007292 Al), AECFG-592740 (US Patent Publication 20140007292 Al), Pput_1063 (US Patent Publication 2014-0007292 Al), DIG-657 (International Application Publication WO2015 / 195594(A2)), Pput_1064 (US Patent Publication 2014-0007292 Al), GS-135 and derivatives thereof (US Patent Publication 2012-0233726 Al), GS153 and derivatives thereof (US Patent Publication 2012-0192310 Al), GS154 and derivatives thereof (US Patent Publication 2012-0192310 Al), GS155 and derivatives thereof (US Patent Publication 2012-0192310 Al), SEC. ID. No. 2 and derivatives thereof as described in US Patent Publication 2012-0167259 Al, SEC. ID. No. 2 and derivatives thereof as described in US Patent Publication 2012-0047606 Al, SEC. ID. No. 2 and derivatives thereof as described in US Patent Publication 2011-0154536 Al, SEC. ID. No. 2 and derivatives thereof as described in US Patent Publication 2011-0112013 Al, SEC. ID. Nos. 2 and 4 and derivatives thereof as described in US Patent Publication 2010-0192256 Al, SEC. ID. No. 2 and derivatives thereof as described in US Patent Publication 2010-0077507 Al, SEC. ID. No. 2 and derivatives thereof as described in US Patent Publication 2010-0077508 Al, SEC. ID. No. 2 and derivatives thereof as described in US Patent Publication 2009-0313721 Al, SEC. ID. No. 2 or 4 and derivatives thereof as described in US Patent Publication 2010-0269221 Al, SEC. ID. No. 2 and derivatives thereof as described in US Patent No. 7,772,465 (B2), CF161_0085 and derivatives thereof as described in WO2014 / 008054 A2, lepidopteran toxic proteins and their derivatives as described in the publications US patent US2008-0172762 Al, US2011-0055968 Al and US20120117690 Al; SEC. ID. No. 2 and derivatives thereof as described in US7510878(B2), SEC. ID. No. 2 and derivatives thereof as described in US Patent No. 7812129(B1), Cry71Aal and Cry72Aal (US Patent Publication US2016-0230187 Al), Axm¡422 (US Patent Publication US2016-0201082 Al) , Axm¡440 (US Patent Publication US2016-0185830 Al), Axm¡281 (US Patent Publication 2016-0177332 Al), BT0044, BT-0051, BT-0068, BT-0128 and variants thereof (WO 2016- 094159 Al), BT-009, BT-0012, BT-0013, BT-0023, BT0067 and variants thereof (WO 2016-094165 Al), CrylJP578V, CrylJPSl, Cryl JPS1P578V (WO 2016-061208 Al) and the like. Said additional polypeptide for control of coleopteran pests can be selected from the group consisting of an insect inhibitory protein such as, but not limited to, Cry3Bb CQCLLn / LZnZ / E / Yli (U.S. Patent No. 6,501,009), CrylC Variants, Cry3A, Cry3, Cry3B, Cry34 / 35, 5307 Variants, AXMI134 (U.S. Patent Publication 2013-0167264 Al) AXMI-184 (U.S. Patent Publication 2013-0167264 Al) US Patent Publication 2010-0004176 Al), AXMI-205 (US Patent Publication 2014-0298538 Al), AXMI-207 (US Patent Publication 20130303440 Al), AXMI-218, AXMI-220 (US Patent Publication 20140245491A1), AXMI221z, AXMI-223z (US Patent Publication 2014-0196175 Al), AXMI-279 (US Patent Publication 2014-0223599 Al), AXMI-R1 and variants thereof (US Patent Publication 2010-0197592 Al, TIC407, TIC417 , TIC431, TIC807, TIC853, TIC901, TIC1201, TIC3131, DIG-10 (US Patent Publication 2010-0319092 Al), eHIPs (US Patent Application Publication 2010 / 0017914), IP3 and variants thereof (US Patent Publication 2012-0210462 Al), - -Hexatoxin-Hvla (US Patent Application Publication 2014-0366227 Al), PHI-4 variants (US Patent Application Publication 2016-0281105 Al), PIP-72 variants (WO 2016- 144688 Al), PIP-45 variants, PIP-64 variants, PIP-74 variants, PIP-75 variants and PIP-77 variants (WO 2016144686 Al), DIG-305 (WO 2016109214 Al), PIP variants -47 (US Patent Publication 2016-0186204 Al), DIG-17, DIG-90, DIG-79 (WO 2016-057123 Al), DIG-303 (WO 2016-070079 Al) and the like. In other embodiments, said composition / formulation may further comprise at least one additional polypeptide exhibiting insect inhibitory activity with respect to an insect that is not inhibited by another insect inhibitor protein of the present invention, to expand the spectrum of insect inhibition. that is obtained, e.g. e.g., an additional polypeptide that exhibits insect inhibitory activity with respect to Hemipterans or Thysanoptera. The possibility of insects developing resistance to certain insecticides is documented in the art. One strategy for controlling resistance in insects is the use of transgenic crops that express two different insect inhibitory agents that act through different modes of action. Therefore, any insect with resistance to any of the insect inhibiting agents can be controlled with the other insect inhibiting agent. Another insect resistance management strategy uses unprotected plants against Coleopteran or Lepidopteran pest species to provide a refuge for such unprotected plants. A particular example is described in US Patent No. 6,551,962, which is incorporated in its entirety by this reference. Other modalities, such as topically applied pesticidal chemicals designed to control pests that are also controlled by the proteins described herein for use with the proteins in seed treatments, spray, drip, contact formulations, may be applied. directly to the soil (soil wetting), they can be applied to CQCLLn / LZnZ / E / Yli growing plants that express the proteins described herein or can be formulated for application in seeds with one or more transgenes that encode one or more of the proteins described. Such formulations for use in seed treatments can be applied with various adhesives and adherents known in the art. Said formulations may contain synergistic pesticides in the mode of action with the described proteins, such that the pesticides in the formulation act through a different mode of action to control the same or similar pests that can be controlled with the described proteins or that such pesticides control pests on a broader spectrum of hosts or plant pest species that are not effectively controlled by TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, TIC7389, the variant, truncation variant, chimera or pesticidal protein member of the related family. The above composition / formulation may further comprise an agriculturally acceptable carrier such as a bait, a powder, a powder, a pellet, a granule, an aerosol, an emulsion, a colloidal suspension, an aqueous solution, a crystalline / spore preparation of Bacillus, a seed treatment, a recombinant plant / seed / plant tissue / plant cell that is transformed to express one or more of the proteins or bacteria transformed to express one or more of the proteins. Depending on the level of insect inhibition or insecticidal inhibition inherent in the recombinant polypeptide and the level of formulation being applied in a plant or feeding trial, the formulation / composition may include various weight amounts of the recombinant polypeptide, e.g. e.g., from 0.0001% to 0.001% to 0.01% to 1% to 99% by weight of the recombinant polypeptide. EXAMPLES Based on the foregoing, those skilled in the art should note that changes can be made to the specific aspects described and still obtain the same or similar result, without departing from the spirit and scope of the invention. Therefore, the specific functional and structural details described should not be interpreted as exhaustive. It should be understood that the full description of each reference cited is incorporated herein. EXAMPLE 1 Finding of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TICZ386^TICZ388^TICZ389 This example describes the finding of the pesticide proteins TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388 and TIC7389. Sequences encoding novel pesticidal proteins from Brevibacillus laterosporus (Bl) were identified, cloned, their sequences confirmed, and analyzed in insect bioassays. Pesticide proteins TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, PQCLLn / LZnZ / E / Yli TIC7386, TIC7388 and TIC7389 were isolated from the BrevibaciHus / aterosporus strains indicated in Table 3 and represent novel pesticide proteins belonging to the Cry43 toxin family. Table 3. Novel Crv43 pesticide toxin proteins and corresponding BrevibaciHus aterosporus strains. eocLLn / Lznz / E / Yii SEC Toxin ID. DNA No. SEQ. ID. protein # BrevibaciHus / aterosporus strains Length (a.a.) TIC7040 1 2 DSC005019 1259 TIC7040HT 3 4 DSC005019 1295 TIC7042 11 12 DSC005973 1266 TIC7381 13 14 DSC006713 12 69 TIC7382 15 16 DSC007657 1246 TIC7383 17 18 DSC008106 1256 TIC7386 29 30 DSC007651 1279 TIC7388 31 32 DSC007962 1269 TIC7389 33 34 DSC006878 1319 Polymerase chain reaction (PCR) primers were designed according to the contigs derived from the sequencing of each of the BrevibaciHus iaterosporus strains indicated in Table 3. Amplicons of the full-length coding sequence were produced for each protein toxin using total DNA isolated from each of the strains listed in Table 3. With respect to TIC7040, a coding sequence of 3888 bp was produced by amplification and this differed from the predicted coding sequence of 3780 bp. The amplified coding sequence and corresponding amino acid sequence is denoted as “TIC7040HT”, to distinguish it from the intended original contig, TIC7040. Each of the amplicons, with the exception of TIC7040, was cloned using methods known in the art into Bacillus thuringiensis (Bt) expression vectors operably linked to a promoter that allows Bt expression. EXAMPLE 2 TIC7040HT, TIC7042, TIC7381, TIC7382 and TIC7383 demonstrate activity against Coleoptera and Lepidoptera in insect bioassays This example illustrates the inhibitory activity that the TIC7040HT, TIC7042, TIC7381, TIC7382 and TIC7383 proteins presented against various species of Coleoptera and Lepidoptera. The pesticidal proteins TIC7040HT, TIC7042, TIC7381, TIC7382, and TIC7383 were expressed in Bt and tested for toxicity against various Lepidopteran and Coleopteran species. Preparations of each toxin were tested against the coleopteran species western corn lacewing (Diabrotica virgifera virgifera, WCR), Cry3Bb-resistant western corn lacewing (Diabrotica virgifera virgifera, WCRHP), northern corn lacewing (Diabrotica barberi, NCR), southern corn chrysomelid {Diabrotica undecimpunctata howardii, SCR) and doryphora {Leptinotarsa ​​decemiineata, CPB). Preparations of each toxin were also tested against the lepidopteran species black cutworm (Agrotis ipsilon, VON), corn earworm (He / icoverpa zea, (CEW), also known as soybean earworm, and cotton bollworm). ), diamondback moth (Plutella xyiosteiia, DBM), corn bollworm (Ostrínia nubiiaiis, ECB), military caterpillar (Spodoptera frugiperda, VAN), army worm (Spodoptera eridania, SAW), soybean looper worm (Pseudopiusia indudes, SBL), corn borer (Diatraea grandiosella, SWCB), tobacco budworm (Heiiothis virescens, TBW) and legume caterpillar (Anticarsia gemmatalis, VBC). Toxin preparations were also tested against the Hemipteran species ligus bug (Lygus Hneoiarís), opaque plant bug (Lygushesperus), and brown bug (Euschistus heros). Bttransformants expressing TIC7040HT, TIC7042, TIC7381, TIC7382, or TIC7383 were cultured for twenty-four (24) hours and spores, as well as solubilized proteins, were added to the insect feed for evaluation. Mortality and stunting were assessed by comparing the growth and development of insects fed a diet with a culture of a Bt strain expressing TIC7040HT, TIC7042, TIC7381, TIC7382 or TIC7383 with insects fed an untreated control culture diet. No activity was observed in hemipteran insect pests for TIC7040HT, TIC7042, TIC7381, TIC7382, or TIC7383. Activity was observed in Coleoptera and Lepidoptera insect pests. The activity of the bioassays with respect to stunting (S) and mortality (M) observed for each of the proteins is presented in tables 4 (coleoptera) and 5 (lepidoptera), in which "+" indicates activity, a empty cell indicates no observed activity and "NT" indicates no toxin analysis was performed for that specific insect pest. CQCLLn / LZnZ / E / Yli cor l Ln / Lznz / E / YiAi Table 4. Activity in bioassays of TIC7040HT, TIC7042, TIC7381, TIC7382 and TIC7383 against beetle insects. WCR WCRHP NCR SCR CPB Toxin S M S M S M S M S M TIC7040HT + + + + + + + + + TIC7042 + + + + + + + + + TIC7381 + + + + + + + + + + TIC7382 + + + + + + + + + TIC7383 + + + + + + + + + TIC7389 + + NT NT NT NT NT NT + + Table 5. Activity in bioassays of TIC7040HT, TIC7042. TIC7381. TIC7382 v TIC7383 against lepidopteran insect pests. BCW CEW DBM ECB FAW SAW SBL SWCB TBW VBC Toxin S M S M S M S M S M S M S M S M S M S M TIC7040HT + + + + + + + + + TIC7042 + + + + + + + + TIC7381 + + + + + + + + + + TIC7382 + + + + + + + + TIC7383 + + + + + As can be seen in Tables 4 and 5, the pesticidal proteins TIC7040HT, TIC7042, TIC7381, TIC7382 and TIC7383 demonstrated activity against many of the coleopteran and lepidopteran insect pest species. TIC7040HT demonstrated activity against WCR, WCRHP, NCR, SCR and CPB coleopteran pests and CEW, DBM, ECB, FAW, SBL, SWCB and VBC lepidopteran pests. TIC7042 demonstrated activity against WCR, WCRHP, NCR, SCR, and CPB coleopteran pests and BCW, CEW, DBM, ECB, FAW, SBL, and VBC lepidopteran pests. The mortality caused by TIC7042 against WCR was very high. TIC7381 demonstrated activity against WCR, WCRHP, NCR, SCR and CPB coleopteran pests and CEW, DBM, ECB, FAW, SBL, SWCB and VBC lepidopteran pests. TIC7382 demonstrated activity against the coleopteran pests WCR, WCRHP, NCR, SCR and CPB and the lepidopteran pests DBM, ECB, SBL, SWCB and VBC. TIC7383 demonstrated activity against the beetle pests WCR, WCRHP, NCR, SCR and CPB and the lepidopteran pests CEW, DBM, ECB and VBC. The pesticide protein TIC7389 demonstrated activity against the beetle pests WCR and CPB. TIC7389 was also tested against the lepidopteran insect pest species corn earworm, bollworm, and soybean earworm, as well as the hemipteran species ligus stink bug and plant opaque stink bug. Stunting was observed in SBL, but not in the other two lepidopteran species and the two hemipteran insect pests. The insect toxins TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383, and TIC7389 demonstrated activity against various species of Coleoptera and Lepidoptera insect pests. The insect toxin TIC7389 demonstrates toxicity toward the lepidopteran insect pest soybean looper. EXAMPLE 3 TIC7040HT and TIC7383 from tryptic digestion and TIC7040HT from guimotryptic digestion demonstrated activity against western corn chrysomelid This example illustrates the inhibitory activity of the tryptic and chymotryptic digestion proteins TIC7040HT and tryptic digestion proteins TIC7383 with respect to western corn chrysomelid. TIC7040HT protein samples were subjected to tryptic and chymotryptic digestion in separate reactions. Similarly, TIC7383 underwent tryptic digestion. Tryptic and chymotryptic digestions were performed using methods known in the art. The digested proteins were analyzed by mass spectrometry to determine the resulting protein fragments. Table 6 presents the tryptic and chymotryptic fragments resulting from TIC7040HT and the tryptic fragment resulting from TIC7383. The digested proteins were used in a bioassay against western corn chrysomelid. Table 6 shows the activity assay of each digested protein preparation and the full-length TIC7040HT and TIC7383 proteins. Table 6. Activity in bioassay of TIC7040HT, TIC7040HT from tryptic digestion v Chymotryptic, TIC7383 v TIC7383 from tryptic digestion with respect to western corn chrysomelid. CQCLLn / LZnZ / E / Yli Toxin SEQ ID. DNA No. SEQ. ID. protein # Amino acid position relative to full-length protein Stunting Mortality TIC7040HT 3 4 + + TIC7040HT_Tryp 70 71 43 to 624 + + TIC7040HT_Chymo 72 73 45 to 641 + + TIC7383 17 18 + + TIC7383_Tryp 74 75 55 to 668 + + As can be seen in Table 6, the tryptic and chymotryptic digestion proteins TIC7040HT and tryptic digestion TIC7383 retained activity against western corn chrysomelid. EXAMPLE 4 Truncations of TIC7040HT and TIC7383 demonstrated activity against Coleoptera in insect bioassays This example illustrates the inhibitory activity that the truncations of TIC7040HT and TIC7383 presented against various species of Coleoptera. Coding sequences encoding truncations of TIC7040HT and TIC7383 were produced with methods known in the art and cloned into bacterial expression vectors for expression in Bt. The truncated proteins were fed in the insect diet and analyzed for activity against Coleoptera insect pests. Table 7 shows the amino acid positions of the truncated TIC7040HT and TIC7383 toxins relative to full-length TIC7040HT and TIC7383. Transformed Bt with expression of truncations of TIC7040HT and TIC7383 were cultured for twenty-four (24) hours and spores, as well as solubilized proteins, were added to the insect diet for evaluation. Mortality and stunting were assessed by comparing the growth and development of insects receiving a diet with a culture of a Bt strain expressing truncations of TIC7040HT or TIC7383 with insects receiving a diet with an untreated control culture. Truncations of TIC7040HT and TIC7383 were analyzed for toxicity against various Coleoptera species. Preparations of each toxin were tested against the beetle species western corn chrysomelid, Cry3Bb-resistant western corn chrysomelid, and doryphora. Activity was observed in Coleoptera insect pests. The activity of the bioassays with respect to stunting (S) and mortality (M) observed for each of the proteins is presented in Table 7, in which "+" indicates activity, an empty cell indicates no observed activity, and " NT” indicates that no toxin analysis was performed with respect to that specific insect pest. The activity of full-length TIC7040HT and TIC7383 is also provided for comparison with the activity of the truncated protein. CQCLLn / LZnZ / E / Yli POP L Ln / ίΖΠΖ / Β / ΥΙΛΙ Table 7. Activity in bioassays of truncations of TIC7040HT v TIC7383 against coleopteran insect pests. WCR WCRHP NCR SCR CPB Toxin SEC. ID. DNA No. SEQ. ID. protein # Amino acid positions relative to full-length protein S M S M S M S M S M TIC7040HT 3 4 + + + + + + + + + TIC7040HT_5 7 8 13 to 611 + + NT NT NT NT + + TIC7040HT_6 9 10 13 to 671 + + NT NT NT NT + + TIC7383 17 18 + + + + + + + + + TIC7383_2 19 20 12 to 1256 + + NT NT NT NT + + TIC7383_3 21 22 1 to 659 + + + NT NT NT NT + + TIC7383_4 23 24 1 to 679 + + NT NT NT NT + + TIC7383_5 25 26 15 to 659 + + NT NT NT NT + + TIC7383_6 27 28 15 to 679 + + NT NT NT NT + + As can be seen in Table 7, truncations of TIC7040HT and TIC7383 retained activity against WCR and CPB. EXAMPLE 5 Design of synthetic coding sequences encoding TIC7040, TIC7040HT. TIC7042. TIC7381. TIC7382. TIC7383 v truncation variants of TIC7040HT, TIC7042, TIC7382 v TIC7383 for expression in plant cells Artificial or synthetic coding sequences were constructed for use in the expression of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 and truncation variants of TIC7040HT, TIC7042, TIC7382 and TIC7383 in plants. These synthetic coding sequences were cloned into binary plant transformation vectors and used to transform plant cells. The synthetic nucleic acid sequences were synthesized according to methods generally described in US Patent No. 5,500,365, avoiding certain sequences with adverse problems, such as A / T-rich plant polyadenylation sequences and ATTTA, but retaining the sequence of B protein amino acids! natural. Table 8 presents the synthetic coding sequences for the pesticide proteins TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 and the truncation variants of TIC7040HT, TIC7042, TIC7382 and TIC7383. Table 8. Synthetic coding sequences used for expression in plant cells encoding TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 v truncation variants of TIC7040HT, TIC7042, TIC7382 and TIC7383. CQCLLn / LZnZ / E / YI Description SEC. ID. DNA No. SEQ. ID. protein no. Additional alanine residue after the initial methionine N-terminal truncation C-terminal truncation Amino acid position with respect to the full-length protein and mutations CR-BREIa.TIC7040.nno_Mc:l 35 2 No No No CR-BREIa.TIC7040_10.nno_Mc:l 36 4 No No No CR-BREIa.TIC7040_10.nno_Mc:3 37 4 No No No CR-BREIa.TIC7040_10.nno_Mc:4 38 4 No No No CR-BREIa.TIC7040_10 .nno_Mc:5 39 4 No No No CR-BREIa.TIC7040_10.nno_Mc:6 40 4 No No No CR-BREIa.TIC7040_10.nno_Mc:7 41 4 No No No CR-BREIa ,TIC7040_l. n no_Mc: 1 42 43 No Yes Yes 15 to 651 CR-BREIa.TIC7040_2.nno_Mc:l 44 10 No Yes Yes 13 to 671 CR-BREIa ,TIC7040_l 1. nno_Mc: 1 45 46 No Yes Yes 14 to 671 CR-BREIa .TIC7040_l 2. nno_Mc: 2 47 48 No No Yes 1 to 660 CR-BREIa .TIC7040_l 3. nno_Mc: 1 49 50 No No Yes 1 to 627 CR-BREIa.TIC7040_14.nno_Mc:l 76 77 Yes Yes Yes 52 to 660 CR-BREIa.TIC7042.nno_Mc:l 51 12 No No No CR-BREIa.TIC7042_l.nno_Mc:l 52 53 No Yes Yes 11 to 646 CR-BREIa.TIC7042_2.nno_Mc:l 54 55 No Yes Yes 11 to 665 CR- BREIa.TIC7381_l.nno_Mc:l 56 57 Yes No No CR-BREIa.TIC7381_2.nno_Mc:l 78 79 Yes No Yes 1 to 658. CR-BREIa.TIC7381_3.nno_Mc:l 80 81 Yes Yes Yes 50 to 658 CR-BREIa .TIC7382_l.nno_Mc:l 58 59 Yes No No CR-BREIa.TIC7382_2.nno_Mc:l 60 61 Yes No Yes 1 to 659 CR-BREIa.TIC7382_3.nno_Mc:l 82 83 Yes Yes Yes 52 to 659 CR-BREIa.TIC7383_l .nno_Mc:l 62 63 Yes No No CR-BREIa.TIC7383_7.nno_Mc:l 64 65 Yes Yes Yes 54 to 668 CR-BREIa.TIC7383_8.nno_Mc:l 66 67 Yes No Yes 1 to 661 CR-BREIa.TIC7383_9.nno_Mc :l 68 69 Yes No Yes 1 to 668 CR-BREIa.TIC7383_19.nno_Mc:l 84 85 No Yes Yes 15 to 668 CR-BREIa.TIC7383_20.nno_Mc:l 86 87 No Yes Yes 15 to 661 CR-BREIa.TIC7383_21. nno_Mc:l 88 89 Yes Yes Yes 54 to 661 CR-BREIa ,TIC7383_22. nno_Mc: 1 90 91 No Yes Yes 54 to 668 cor l Ln / Lznz / E / YiAi Description SEC. ID. DNA No. SEQ. ID. protein no. Additional alanine residue after the initial methionine N-terminal truncation C-terminal truncation Amino acid position with respect to the full-length protein and mutations CR-BREIa.TIC7383_23.nno_Mc: 1 92 93 No Yes Yes 54 to 661 CR-BREIa.TIC7383_24.nno_Mc:2 94 95 No Yes Yes 73 to 661 CR-BREIa.TIC7383_25.nno_Mc:3 96 97 No Yes Yes 94 to 661 CR-BREIa.TIC7383_26.nno_Mc:l 98 99 No Yes Yes 114 to 661 CR-BREIa.TIC7383_27.nno_Mc: 1 100 101 Yes Yes Yes 54 to 658 CR-BREIa.TIC7383_28.nno_Mc: 1 102 103 No Yes Yes 15 to 658 CR-BREIa.TIC7383_29.nno_Mc: 1 104 105 Yes No Yes la 963 CR-BREIa.TIC7383_30.nno_Mc: 1 106 107 Yes No No K964A; R966A; K968A CR-BREIa .TIC7383_31. nno_Mc: 1 108 109 Yes No Yes 1 to 1065; K964A; R966A; K968A CR-BREIa.TIC7383_32.nno_Mc: 1 110 111 Yes No No Elimination 964 to 969 EXAMPLE 6 Expression cassettes for expression of TIC7040, TIC7040HT, TIC7042, TIC7381. TIC7382, TIC7383 v truncation variants of TIC7040HT, TIC7042, TIC7382 v TIC7383 in plant cells Various plant expression cassettes were designed with the sequences indicated in Table 8. These expression cassettes are useful for transient expression in plant protoplasts or transformation of plant cells. Typical expression cassettes are designed with respect to the eventual placement of the protein in the plant cell. For a plastid-targeting protein, the coding sequences of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 or truncation variants of the synthetic pesticide protein TIC7040HT, TIC7042, TIC7382 or TIC7383 are operably linked in frame to a sequence coding signal peptide for targeting to the chloroplast. The resulting plant transformation vectors comprise a first transgene cassette for expression of the pesticidal protein, comprising a consecutive promoter, operably linked 5' to a leader, operably linked 5' to an intron (or , optionally, without intron), operably linked 5' to a synthetic coding sequence encoding a TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 protein or truncation variant of TIC7040HT, TIC7042, TIC7382 or TIC7383 targeting plastid or non-targeting which, in turn, is operatively linked 5' to a 3' UTR, and a second transgene cassette for selection of transformed plant cells with glyphosate or antibiotic selection. All of the elements listed above are placed contiguously, often with additional sequence provided for construction of the expression cassette, such as endonuclease restriction sites or junction-independent cloning sites. EXAMPLE 7 TIC7382 provides effective resistance to western corn chrysomelid when expressed in stably transformed corn plants This example illustrates the inhibitory activity that TIC7382 truncations exhibited against Coleoptera, such as the western corn chrysomelid, when expressed in plants and supplied as food to the respective insect pests. Binary plant transformation vectors were cloned with transgene cassettes designed to express non-targeting TIC7382 (CR-BREIa.TIC7382_l.nno_Mc:l), as well as the truncation variants CR-BREIa.TIC7382_2.nno_Mc:l and CR-BREIa.TIC7382_3. nno_Mc:l, using methods known in the art. The plant transformation vectors comprised a first transgene cassette for expression of the pesticide protein TIC7382 or one of the truncation variants comprising a root-preferred promoter, operably linked 5' to a leader, operably linked 5' to an intron, operably linked 5' to a synthetic coding sequence encoding TIC7382 or the truncation variants, each of which comprised an additional alanine residue immediately after the initial methionine which, in turn, was linked operatively 5' to a 3' UTR, and a second transgene cassette for selection of transformed plant cells using glyphosate. The resulting vectors were used to stably transform corn plants with methods known in the art. Individual T-DNA insertion events were selected and cultured. The pesticide activity against western corn chrysomelid was analyzed with feeding on the roots of stably transformed corn plants. Ro stably transformed plants were used to analyze resistance to Coleoptera as well as the generation of Fi progeny. Multiple events were selected from single copies of each binary vector transformation. A portion of the events arising from each binary vector transformation was used in the Coleoptera assay, while another portion of the events was used to generate Fi progeny for subsequent analysis. The Ro test plants were transplanted into eight-inch pots. Plants were inoculated with western corn chrysomelid eggs. The eggs were incubated for approximately ten (10) days before inoculation, to allow hatching four (4) days after inoculation and to ensure the survival of a sufficient number of larvae that could attack the CQCLLn / LZnZ / E / Yli roots of corn. The transformed plants were inoculated at approximately the V2 to V3 stage. The plants were grown after infestation for approximately twenty-eight (28) days. The plants were removed from the pots and the roots were carefully washed to remove all soil. Root damage was evaluated using a damage rating scale from 1 to 5, as presented in Table 9. A comparison with the negative control was also made to ensure correct performance of the assay. Low root damage scores indicate that the TIC7382 protein or truncation variants conferred resistance to WCR. An RDR rating of 1.0 to 2.5 represents good effectiveness, an RDR rating of 2.6 to 3.5 represents average effectiveness, and an RDR rating of 3.6 to 5.0 represents low effectiveness. PQCLLn / LZnZ / E / Yli Table 9. Ro Root Damage Rating Values Root Damage Rating Description 1 No visible feeding 2 Some feeding, no cutting 3 Cutting at least one root 4 Cutting entire node 5 Cutting more than one node For the Fi assay, western corn chrysomelid eggs were incubated for approximately ten (10) days to allow hatching within four (4) days of inoculation. Plants were inoculated at approximately the V2 to V3 stage. Each pot was inoculated with around two thousand eggs. The plants were grown after infestation for approximately twenty-eight (28) days. The plants were removed from the pots and the roots were carefully washed to remove all soil. Root damage was evaluated using a damage rating scale from 0 to 3, as presented in Table 10. A comparison with the negative control was made to ensure correct performance of the test. Low root damage scores indicate that TIC7382 or truncation conferred resistance to WCR. An Fi RDR score of 0.0 to 0.75 represents good effectiveness, an RDR score of 0.76 to 1.5 represents average effectiveness, and an RDR score of 1.6 to 3.0 represents low effectiveness. CQCLLn / LZnZ / E / Yli Table 10. F1 Root Damage Rating Values Root Damage Rating Description 0 No visible feeding 0.01 to 0.09 Feeding marks and traces 0.1 to 0.9 Cutting of roots, but not reaching a whole node 1.0 to 1.9 Destruction of at least one whole node (or equivalent) up to 1.5 inches plants 2.0 to 2.9 Removal of two or more nodes 3 Removal of three or more nodes Table 11 shows the average root damage scores (RDRs) analyzed for the TIC7382 protein and truncation variants. Table 11. Average root damage scores (RDR) of transgene maize plants with TIC7382 expression or truncation variants. Description SEC coding sequence. ID. SEC. ID. protein # Amino acid position relative to full-length protein Average RDR in Ro Average RDR in Fi CR- BREIa .TIC7382_1. n no_Mc: 1 58 59 3.7 2.4 CR- BREIa .TIC7382_2.n no_Mc: 1 60 61 1 to 658 3.3 1.1 CR- BREIa .TIC7382_3.n no_Mc: 1 82 83 50 to 658 1.6 1.0 As can be seen in Table 11, a C-terminal truncation of the TIC7382 protein resulting in the truncation variant CR-BREIa.TIC7382_2.nno_Mc:l improved efficacy with respect to CR-root damage scores. BREIa.TIC7382_l.nno_Mc:l. Truncation of the TIC7382 protein at both the N-terminus and C-terminus resulting in the truncation variant CR-BREIa.TIC7382_3.nno_Mc:l resulted in less damage to maize roots and further improved efficacy, as demonstrated via a lower root damage rating in Ro, compared to CR root damage ratings BREIa.TIC7382_l.nno_Mc:l and CR-BREIa.TIC7382_2.nno_Mc:l. EXAMPLE 8 Activity assay of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382. TIC7383 v truncation variants of TIC7040HT, TIC7042, TIC7382 or TIC7383 against chrysomelid beetle pests of corn when expressed in corn plants with stable transformation This example illustrates the inhibitory activity of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 or truncation variants of TIC7040HT, TIC7042, TIC7382 or TIC7383 against different species of beetles that feed on corn roots. Binary plant transformation vectors with transgene cassettes designed to express TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 or truncation variants of TIC7040HT, TIC7042, TIC7382 or TIC7383, targeting or non-targeting, were cloned using methods known in the art. and comprise the sequences illustrated in Table 8. The resulting vectors are used to stably transform corn plants transformed with methods known in the art. Individual T-DNA insertion events are selected and cultured. The pesticidal activity against the beetle pests is analyzed: western corn chrysomelid (Diabrotica virgifera virgifera, WCR). Brazil (Diabrotica baiteata, BZR), southern corn chrysomelid (Diabrotica undecimpunctata howardü, SCR), doryphora (Leptinotarsa ​​decemiineata, CPB) or a complex of Brazilian corn chrysomelids (BCR, with Diabrotica viriduia and Diabrotica speciosa) that feed from the roots of stably transformed corn plants. Ro stably transformed plants are used to analyze resistance to Coleoptera, as well as the generation of Fi progeny. Multiple events are selected from individual copies of each binary vector transformation. A portion of the events arising from each binary vector transformation in the Coleoptera assay in Ro is used, while another portion of the events is used to generate Fi progeny for further analysis. Ro test plants are transplanted into eight-inch pots. Plants are inoculated with eggs of western corn chrysomelid, northern corn chrysomelid, or southern corn chrysomelid. The eggs are incubated for approximately ten (10) days before inoculation, to allow hatching four (4) days after inoculation, to ensure the survival of a sufficient number of larvae that could attack the roots of the corn. The transformed plants are inoculated at approximately the V2 to V3 stage. The plants are grown after infestation for approximately twenty-eight (28) days. The plants are removed from the pots and the roots are carefully washed to remove all soil. The damage is evaluated in the CQCLLn / LZnZ / E / Yli roots using a damage rating scale from 1 to 5, as presented in Table 9 of Example 5. A comparison with negative controls is also made to ensure correct performance of the assay. Multiple Ro events are used for each binary vector transformation in the Coleoptera assay. Low root damage scores indicate that TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 or the truncation variants of TIC7040HT, TIC7042, TIC7382 OTIC7383 conferred resistance to the tested beetle pest. A portion of the stably transformed Ro events arising from each binary vector transformation was used to produce progeny Fi. Stably transformed Ro plants can self-fertilize and produce Fi progeny. The Fi seed was planted. Heterozygous plants were identified with molecular methods known in the art and used for assays against Coleoptera pests, as well as toxin protein expression measurements in ELISA. A portion of the heterozygous Fi progeny from each event was used for insect analysis, while another portion was used to measure toxin protein expression. Western Corn Lacewing, Northern Corn Lacewing, or Southern Corn Lacewing eggs were incubated for approximately ten (10) days, to allow hatching within four (4) days of inoculation. For WCR, each pot is inoculated with around two thousand eggs. For NCR, fewer eggs can be used, due to the lower availability of eggs of this species. Plants are inoculated at approximately the V2 to V3 stage. The plants are grown after infestation for approximately twenty-eight (28) days. The plants are removed from the pots and the roots are carefully washed to remove all soil. Root damage is assessed using a damage rating scale from 0 to 3, as presented in Table 10 of Example 5. A comparison with the negative control is made to ensure correct performance of the assay. Low root damage scores indicate that the protein TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 or truncation variants of TIC7040HT, TIC7042, TIC7382 or TIC7383 conferred resistance to the Coleopteran pest. EXAMPLE 9 Activity assay of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 or truncation variants of TIC7040HT, TIC7042, TIC7382 or TIC7383 against lepidopteran pests when expressed in maize, soybean or cotton plants with stable transformation This example illustrates the activity assay against various tissue-feeding lepidopteran pest species of stably transformed corn, soybean or cotton plants expressing TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 or variants of truncation of TIC7040HT, TIC7042, TIC7382 or TIC7383. CQCLLn / LZnZ / E / Yli Binary plant transformation vectors with transgene cassettes designed to express TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 or truncation variants of TIC7040HT, TIC7042, TIC7382 or TIC7383, plastid-targeted or non-targeted, were cloned using methods known in the technique and comprise the coding sequences presented in Table 8. Maize, soybean or cotton were transformed with the binary transformation vectors described above, using an Agrobacterium-mediated transformation method. The transformed cells were induced to form plants with methods known in the art. Bioassays were performed with plant leaf discs, analogous to those described in US Patent No. 8,344,207. An untransformed corn, soybean or cotton plant was used to obtain tissue for use as a negative control. Multiple transformation events of each binary vector were evaluated against lepidopteran pests such as, but not limited to, black cutworm, corn earworm, diamondback moth, corn bollard, military caterpillar, armyworm, looper. soybean, corn borer, tobacco budworm and legume caterpillar. Insects that demonstrated stunting and / or mortality in the insect bioassay are determined to be susceptible to the effects of the insect toxin pesticidal protein tested TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 or the truncation variant of TIC7040HT, TIC7042, TIC7382 or TIC7383. EXAMPLE 10 Activity assay of TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 or truncation variants of TIC7040HT, TIC7042, TIC7382 or TIC7383 against oulauilla pests when expressed in canola plants with stable transformation This example illustrates the assay of activity against various flea species, when allowed to feed on whole transgenic canola plants or tissues derived from transgenic canola plants expressing TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 or variants of truncation of TIC7040HT, TIC7042, TIC7382 or TIC7383. Binary plant transformation vectors with transgene cassettes designed to express either TIC7040, TIC7040HT, TIC7042, TIC7381, TIC7382, TIC7383 or truncation variants of TIC7040HT, TIC7042, TIC7382 or TIC7383, plastid-targeted or non-targeted, were cloned using methods known in the art. technique and comprise the coding sequences presented in Table 8. The resulting binary transformation vectors were used to stably transform transformed canola plant cells with methods known in the art. The transformed cells were induced to form plants. Plant leaf disc bioassays, analogous to those described in US Patent No. 8,344,207, were performed using flea CQCLLn / LZnZ / E / Yli collected in the field. An untransformed canola plant was used to obtain tissue for use as a negative control. Multiple transformation events of each binary vector were evaluated against flea beetle pests such as, but not limited to, aphid beetle (Phyllotreta cruciferae}, cruciferous banded flea {Phyllotreta stríolatá) and jumping flea {Phyllotreta pusilla). Flea mortality was determined each day as they continued feeding. The leaf discs were changed every two (2) to three (3) days over a period of twelve (12) days, to ensure the availability of fresh material for the flea beetles to feed on and to reduce the impact of protein degradation on the sample. Alternatively, transformed canola plants can be planted in a field with flea infestations. Plants can be placed in a tent to prevent fleas emerging from the soil from escaping the experiment plots. Canola leaf damage ratings can be made to determine which plants experienced the least damage and demonstrated resistance to flea beetles. EXAMPLE 11 Truncation of TIC7383 improves efficacy against corn chrysomelid in stably transformed corn plants This example illustrates improving the efficiency of TIC7383 through truncations at the N-terminus, the C-terminus, or both ends. Binary plant transformation vectors were cloned with transgene cassettes designed to express TIC7383 without targeting, as well as the truncation variants, using a method known in the art. The plant transformation vectors comprised a first transgene cassette for expression of the pesticide protein TIC7383 or truncation variants comprising a root-preferred promoter, operably linked 5' to a leader, operably linked 5' to an intron , operably linked 5' to a synthetic coding sequence encoding TIC7383 or truncation variants, some of which comprised an additional alanine residue immediately after the initial methionine which, in turn, was operably linked 5' to a 3' UTR, and a second transgene cassette for selection of transformed plant cells using glyphosate. The resulting vectors were used to stably transform corn plants with methods known in the art. Individual T-DNA insertion events were selected and cultured. The pesticide activity against western corn chrysomelid was analyzed with feeding on the roots of stably transformed corn plants. Ro stably transformed plants were used to analyze western maize chrysomelid resistance as well as the generation of Fi progeny. Multiple events were selected from single copies of each binary vector transformation. A part of the CQCLLn / LZnZ / E / Yli events arising from each binary vector transformation in the Coleoptera assay, while another part of the events was used to generate Fi progeny for further analysis. The root damage score values ​​in Ro and Fi were determined using the root damage score values ​​presented in Tables 9 and 10, respectively, of Example 7. Table 12 shows the average values ​​of the scores. of root damage obtained from the stably transformed maize plants Ro and Fi with expression of TIC7383 and truncation variants. The protein expression levels of TIC7383 and the corresponding truncation variants are also shown in Table 12 and are expressed as parts per million (ppm). As can be seen in Table 12, truncations at the N-terminus, the C-terminus, or both ends improved efficacy in some of the truncation variants, as demonstrated by lower average root damage score values ​​with with respect to the full-length TIC7383 protein (CR-BREIa.TIC7383_l.nno_Mc:l). Truncations of the TIC7383 toxin also improved expression in planta in most cases. Table 12. Average values ​​of root damage scores (RDR) of maize plants stably transformed with expression of TIC7383 v truncation variants. POP L LO / ίΖΠΖ / Β / ΥΙΛΙ Description Additional alanine residue after initial methionine Amino acid position relative to CR-BREIa.TIC7383_l.nno_ Mc:l Protein expression (ppm) Average RDR in Ro Average RDR in Fi CR-BREIa.TIC7383_l.nno_Mc:l Yes 11.9 3.8 2.2 CR-BREIa.TIC7383_7.nno_Mc:l Yes 54 to 668 421.3 2.9 1.6 CR-BREIa.TIC7383 8.nno Mc:l Yes 1 to 661 289.2 2.4 CR-BREIa.TIC7383_9.nno_Mc:l Yes 1 to 668 317.2 3.3 Cr -breia.tic7383_19.nno_mc: l no 15 to 668 23.7 3.3 Cr -breia.tic7383_20.nno_mc: l no 15 to 661 29.1 3.9 Cr -breia.tic7383 21.nno mc: l Yes 54 to 661 617.4 2.7 CR-BREIA .TIC7383_22.nno_Mc:l No 54 to 668 451.3 2.6 CR-BREIa.TIC7383_23.nno_Mc:l No 54 to 661 343.1 2.8 CR-BREIa.TIC7383_24.nno_Mc:2 No 73 to 661 356.5 2.9 CR-BREIa. TIC7383 26.no Mc:l No 114 to 661 8.5 3.9 CR-BREIa.TIC7383_27.nno_Mc:l Yes 54 to 658 356.2 2.9 CR-BREIa.TIC7383_28.nno_Mc:l No 15 to 658 25.4 3.7 EXAMPLE 12 Assay of the activity of chimeras of TIC7381, TIC7382, TIC7383 v TIC7042 against western maize chrysomelid in stably transformed maize plants 1) This example illustrates the design of chimeras of TIC7381, TIC7382, TIC7383 and TIC7042, as well as the analysis of activity against western corn chrysomelid (WCR), in plants stably transformed with expression of the chimeras. Chimeras of TIC7381, TIC7382, TIC7383 and TIC7042 were designed in which domains one and two (D1D2) of one toxin were combined with the third domain (D3) of another toxin. Table 13 below shows the composition of each chimera. Table 13. Composition of the TIC7381, TIC7382, TIC7383 and TIC7042 chimeras. CQCLLn / LZnZ / E / Yli Description SEC. ID. SEQ nucleotide no. ID. protein # D1D2 D3 GOI-TIC10743.nno_Mc:l 112 113 TIC7383 TIC7042 GOI-TIC10744.nno_Mc:l 114 115 TIC7383 TIC7381 GOI-TIC10745.nno_Mc:l 116 117 TIC7383 TIC7382 GOI -TIC10746.nno_Mc:l 118 119 TIC7382 TIC7383 GOI-TIC10747.nno_Mc:l 120 121 TIC7381 TIC7383 GOI-TIC10748.nno_Mc:l 122 123 TIC7042 TIC7383 Binary plant transformation vectors were cloned with transgene cassettes designed to express non-targeting chimeras of TIC7381, TIC7382, TIC7383 and TIC7042, using methods known in the art. The plant transformation vectors comprised a first transgene cassette for expression of the chimeric toxin pesticidal protein comprising a root-preferred promoter, operably linked 5' to a leader, operably linked 5' to an intron, operably linked 5' operatively to a synthetic coding sequence encoding the chimeras of TIC7381, TIC7382, TIC7383 and TIC7042, which comprised an additional alanine residue immediately after the initial methionine which, in turn, was 5' operatively linked to a 3' UTR, and a second transgene cassette for selection of transformed plant cells using glyphosate. The resulting vectors were used to stably transform corn plants with methods known in the art. Individual T-DNA insertion events were selected and cultured. The pesticide activity against western corn chrysomelid was analyzed with feeding on the roots of stably transformed corn plants. Ro stably transformed plants were used to analyze western maize chrysomelid resistance as well as the generation of Fi progeny. Multiple events were selected from single copies of each binary vector transformation. A portion of the events arising from each binary vector transformation was used in the Coleoptera assay, while another portion of the events was used to generate Fi progeny for subsequent analysis. The root damage score values ​​in Ro and Fi were determined using the root damage score values ​​presented in Tables 9 and 10, respectively, of Example 7. Table 14 shows the average score values. of root damage obtained from the stably transformed plants Ro and Fi with expression of the chimeras of TIC7381, TIC7382, TIC7383 and TIC7042 or truncation variants, in which "NT" indicates not analyzed. A comparison was made with an N-terminally truncated TIC7382 variant and a C-terminal protoxin domain (CR-BREIa.TIC7382_3.nno_Mc:l), as well as an N-terminally truncated TIC7383 variant and a C-terminal protoxin domain. C (CR-BREIa.TIC7383_7.nno_Mc:l). Table 14. Average values ​​of root damage scores (RDRj of stably transformed maize plants, with expression of chimeras of TIC7381, TIC7382, TIC7383 v TIC7042 against western maize chrysomelid. CQCLLn / LZnZ / E / Yli Description Avg. TIC10747.nno_Mc:l NT NT GOI-TIC10748.nno_Mc:l 3.3 2.7 CR-BREIa.TIC7382_3.nno_Mc:l 1.6 1.0 CR-BREIa.TIC7383_7.nno_Mc:l 3 1.5 As can be seen in Table 14, the chimeric toxin GOI-TIC10746.nno_Mc:l that comprised domains one and two of TIC7382 and domain three of TIC7383 provided better efficacy in Ro and Fi with respect to the negative control, CR-BREIa .TIC7382_3.nno_Mc:l and CRBREIa.TIC7383_7.nno_Mc:l. Four Fi events with GOI expression were included in the trial. TIC10746.nno_Mc:l. The values ​​of root damage scores ranged from 0.11 to 0.79 with (RDR: 0.11, 0.20, 0.30, and 0.79). The event with expression of GOI-TIC10746.nno_Mc:l, with an RDR of 0.11, was equal to a commercial control. In addition to the data presented above, the protein isolated from bacteria expressing the chimeric toxin GOI-TIC10746.nno_Mc:l also demonstrated activity against northern corn chrysomelid when presented in a feeding bioassay. EXAMPLE 13 Assay of the activity of TIC7382 v TIC7383 chimeras against corn chrysomelid in stably transformed corn plants This example illustrates the design of chimeras of TIC7382 and TIC7383, as well as the analysis of activity against western corn chrysomelid (WCR), in plants stably transformed with expression of the chimeras. Synthetic coding sequences encoding chimeric toxins composed of domains one and two of TIC7382 and domain three of TIC7383, designed for expression in plants, were cloned using methods known in the art. The chimeric toxin TIC10746NTermExtl (SEQ ID NO: 125, encoded by SEQ ID NO: 124) comprises the N-terminal extension of TIC7382. The chimeric toxin TIC10746NTermExt2 (SEQ ID NO: 127, encoded by SEQ ID NO: 126) comprises the N-terminal extension of TIC7383. The synthetic coding sequences were cloned into binary plant transformation vectors similar to those described in Example 12 and used to transform corn plants. Root analyzes were performed as previously described in Example 8 for Ro and Fi plants after infestation with corn chrysomelid species such as western corn chrysomelid (Diabrotica virgifera virgifera, WCR), northern corn chrysomelid (Diabrotica barberi , NCR), Mexican corn chrysomelid (Diabrotica virgifera zeae, MCR), Brazilian corn chrysomelid (Diabrotica baiteata, BZR), southern corn chrysomelid (Diabrotica undecimpunctata howardii, SCR), doryphora (Leptinotarsa ​​decemiineata, CPB) or a Brazilian corn chrysomelid complex (BCR, with Diabrotica viriduia and Diabrotica speciosa). The low average root damage score (RDR) values ​​of Ro and Fi plants relative to non-transformed maize plant controls demonstrate resistance to maize chrysomelid species conferred by expression of the chimeric toxins. All compositions described and claimed herein can be made and practiced without undue experimentation by virtue of the present description. While the compositions of the present invention have been described through the preferred preferred embodiments, it will be apparent to those skilled in the art that variations, changes, modifications and alterations can be applied to the compositions described herein without departing from CQCLLn / LZnZ / E / Yli of the concept, spirit and actual scope of the invention. More specifically, it will be apparent that the agents described herein can be substituted for certain chemically and physiologically related agents and obtain the same or similar results. Such modifications and similar substitutes apparent to those skilled in the art are deemed to fall within the spirit, scope and concept of the invention, as defined in the appended claims. All published publications and patent documents cited in the specification are incorporated herein by reference to the same extent as they would be incorporated if each individual publication or patent application were mentioned as specifically incorporated herein by reference. .

Claims

1. A recombinant nucleic acid molecule characterized in that it comprises a heterologous promoter operatively linked to a polynucleotide segment encoding a pesticide protein or a pesticide fragment thereof, wherein: a) said pesticide protein comprises the amino acid sequence of SEC. ID. No. 61, or SEC. ID. No. 83; b) said pesticide protein comprises an amino acid sequence having at least 99% identity with respect to SEC. ID. No. 61, or SEC. ID. No. 83; c) said polynucleotide segment is hybridized under rigorous hybridization conditions with a polynucleotide having the nucleotide sequence of SEC. ID. No. 60 or SEC. ID. No.

82.

2. The recombinant nucleic acid molecule of claim 1, characterized in that: a) The recombinant nucleic acid molecule comprises a sequence expressing the pesticide protein in a plant; b) the recombinant nucleic acid molecule is expressed in a plant cell to produce an amount of the pesticide protein that is effective as a pesticide; c) the recombinant nucleic acid molecule is operatively linked to a vector, and said vector is selected from the group consisting of a plasmid, phagemid, bacmid, cosmid, and yeast or bacterial artificial chromosome.

3. The recombinant nucleic acid molecule of claim 1, characterized in that it is comprised in a host cell, wherein said host cell is selected from the group consisting of a bacterium and a plant cell.

4. The recombinant nucleic acid molecule of claim 3, characterized in that the bacterial host cell is derived from a genus of bacteria selected from the group consisting of: Agrobacterium, Rhizobium, Bacillus, BrevibaciHus, Escherichia, Pseudomonas, Klebsiella, Pantoea, and Erwinia.

5. The recombinant nucleic acid molecule of claim 4, characterized in that the Bacillus species is Bacillus cereus or Bacillus thuringiensis, wherein the BrevibaciHus species is BrevibaciHus iaterosperus or the Escherichia species is Escherichia coii.

6. The recombinant nucleic acid molecule of claim 3, characterized in that said plant cell is a dicotyledonous or monocotyledonous plant cell.

7. The recombinant nucleic acid molecule of claim 6, characterized in that said plant host cell is selected from the group consisting of a plant cell of CQCLLn / LZnZ / E / Yli alfalfa, banana, barley, bean, broccoli, cabbage, Brassica, carrot, tapioca, castor bean, cauliflower, celery, chickpea, Chinese cabbage, citrus plant, coconut, coffee, maize, clover, cotton, a cucurbit, cucumber, Douglas fir, eggplant, eucalyptus, flax, garlic, grape, hops, leek, lettuce, Norway pine, millet, melons, walnut, oats, olive, onion, ornamental plants, palm, pasture grass, pea, peanut, pepper, pigeon pea, pine, potato, poplar, squash, Monterey pine, radish, rapeseed, rice, root vegetables, rye, safflower, shrub, sorghum, southern pine, soybean seed, spinach, squash, strawberry, sugar beet, sugar cane, sunflower, sweet corn, American storax, sweet potato, prairie grass, tea, tobacco, tomato, triticale, lawn grass, watermelon, and wheat.

8. The recombinant nucleic acid molecule of claim 1, characterized in that said pesticide protein exhibits activity against a coleopteran insect.

9. The recombinant nucleic acid molecule of claim 8, characterized in that said insect is a western maize chrysomelid, southern maize chrysomelid, northern maize chrysomelid, Mexican maize chrysomelid, Brazilian maize chrysomelid, doryphora, Brazilian maize chrysomelid complex with Diabrotica viriduta and Diabrotica speciosa, aphid beetle, banded cruciferous flea beetle, or jumping flea beetle.

10. The recombinant nucleic acid molecule of claim 1, characterized in that said pesticide protein exhibits activity against a species of insects of the order Lepidoptera.

11. The recombinant nucleic acid molecule of claim 10, characterized in that said insect is a black cutworm, corn earworm, diamondback moth, European borer, armyworm, fall armyworm, soybean looper, southwestern corn borer, tobacco budworm, pulseworm, sugarcane miner, lesser borer, African fall armyworm, beet armyworm, cabbage caterpillar, defoliator, or pink bollworm.

12. A plant or part thereof characterized in that it comprises the recombinant nucleic acid molecule of claim 1.

13. The plant or part thereof of claim 12, characterized in that said plant is a monocotyledonous plant or a dicotyledonous plant.

14. The plant or part thereof of claim 12, characterized in that the plant is selected from the group consisting of alfalfa, banana, barley, bean, broccoli, cabbage, Brassica, carrot, tapioca, castor bean, cauliflower, celery, chickpea, Chinese cabbage, citrus plant, coconut, coffee, maize, clover, cotton, a cucurbit, cucumber, Douglas fir, eggplant, eucalyptus, flax, garlic, grape, hops, leek, lettuce, Norway pine, millet, melons, walnut, oats, olive, onion, ornamental plants, palm, pasture grass, pea, peanut, pepper, pigeon pea, pine, potato, poplar, pumpkin, Monterey pine, radish, rapeseed, rice, root crops, rye, safflower, shrub, sorghum, PQCLLn / LZnZ / E / Yli southern pine, soybean seed, spinach, squash, strawberry, sugar beet, sugar cane, sunflower, sweet corn, American storax, sweet potato, prairie grass, tea, tobacco, tomato, triticale, lawn grass, watermelon, and wheat.

15. A seed of the plant of claim 12, characterized in that said seed comprises said recombinant nucleic acid molecule.

16. An insect-inhibiting composition characterized in that it comprises the recombinant nucleic acid molecule of claim 1.

17. The insect-inhibiting composition of claim 16, characterized in that it further comprises a nucleotide sequence encoding at least one additional pesticidal agent different from said pesticidal protein.

18. The insect-inhibiting composition of claim 17, characterized in that said additional pesticide agents are selected from the group consisting of an insect-inhibiting protein, an insect-inhibiting cdRNA molecule, and an auxiliary protein.

19. The insect-inhibiting composition of claim 17, characterized in that said additional pesticide agents exhibit activity against one or more pest species of the orders Lepidoptera, Coleoptera or Hemiptera.

20. The insect-inhibiting composition of claim 19, characterized in that said additional pesticidal protein(s) are selected from the group consisting of CrylA, CrylAb, CrylAc, CrylA.105, CrylAe, CrylB, CrylC, variants of CrylC, CrylD, CrylE, CrylF, chimeras of CrylA / F, CrylG, CrylH, Cryll, CrylJ, CrylK, CrylL, Cry2A, Cry2Ab, Cry2Ae, Cry3, variants of Cry3A, Cry3B, Cry4B, Cry6, Cry7, Cry8, Cry9, Cryl5, Cry34, Cry35, Cry43A, Cry43B, Cry51Aal, ET29, ET33, ET34, ET35, EG66, ET70, TIC400, TIC407, TIC417, TIC431, TIC800, TIC807, TIC834, TIC853, TIC900, TIC901, TIC1201, TIC1415, TIC2160, TIC3131, TIC836, TIC860, TIC867, TIC869, TIC1100, VIP3A, VIP3B, VIP3Ab, AXMI-AXMI-, AXMI-88, AXMI-97, AXMI-102, AXMI-112, AXMI-117, AXMI100, AXMI-115, AXMI-113 and AXMI-005, AXMI134, AXMI-150, AXMI-171, AXMI-184, AXMI-196, AXMI204, AXMI-207, AXMI-209, AXMI-205, AXMI-218, AXMI-220, AXMI-221Z, AXMI-222z, AXMI-223z, AXMI-224Z and AXMI-225z, AXMI-238, AXMI-270, AXMI-279, AXMI-345, AXMI-335,AXMI-R1 and variants thereof, IP3 and variants thereof, DIG-3, DIG-5, DIG-10, DIG-657, DIG-11, Cry71Aal, Cry72Aal, variants of PHI-4, variants of PIP-72, variants of PIP-45, variants of PIP-64, variants of PIP-74, variants of PIP-75, variants of PIP-77, Axm¡422, Dig-305, Axm¡440, variants of PIP-47, Axm¡281, BT-009, BT-0012, BT-0013, BT-0023, BT0067, BT-0044, BT-0051, BT-0068, BT0128, DIG-17, DIG-90, DIG-79, CrylJP578V, CrylJPSl and Cryl JPS1P578V., 21. The insect-inhibiting composition of claim 16, characterized in that it comprises a plant cell expressing said recombinant nucleic acid molecule.

22. A basic product characterized in that it is produced from the plant or part thereof CQCLLn / LZnZ / E / Yli of claim 12, wherein the basic product comprises a detectable amount of said recombinant nucleic acid molecule or a pesticide protein encoded by it.

23. The basic product of claim 22, characterized in that it is selected from the group consisting of basic corn packaged by a grain handler, corn flakes, corn tortillas, corn flour, corn syrup, corn oil, corn silage, corn starch, corn cereal and the like, whole or processed cottonseed, cottonseed oil, yarn, seeds and parts of plants processed for food or feed, fiber, paper, biomass and fuel products, such as fuel derived from cottonseed oil or sediments derived from cotton ginning waste, whole or processed soybean seed, soybean oil, soybean protein, soybean meal, soybean flakes, soybean bran, soybean milk, soybean cheese, soybean wine, animal feed containing soybeans, paper containing soybeans, cream containing soybeans, soybean biomass and fuel products produced from soybean plants and parts of soybean plants.

24. A plant resistant to insect infestation, characterized in that the cells of said plant comprise the recombinant nucleic acid molecule of claim 1.

25. A method for controlling a pest of the Coleoptera or Lepidoptera species or a pest infestation, characterized in that it comprises: a) contacting the pest with an insecticidal amount of a pesticidal protein as specified in SEC. ID. No. 61 or SEC. ID. No. 83; b) contacting the pest with an insecticidal amount of one or more pesticidal proteins having an amino acid sequence that is at least 99% identical to that in SEC. ID. No. 61 or SEC. ID. No.

83.

26. A method for detecting the presence of the recombinant nucleic acid molecule of claim 1 in a sample containing plant genomic DNA, characterized in that it comprises: a) contacting the sample with a nucleic acid probe that hybridizes under rigorous hybridization conditions with genomic DNA of a plant to the DNA molecule of claim 1 and that does not hybridize under said hybridization conditions with genomic DNA of a plant that is otherwise isogenic and without the recombinant nucleic acid molecule of claim 1, wherein the probe is homologous or complementary to SEQ. ID. No. 60 or SEQ. ID. No. 82, or a sequence encoding a pesticide protein with an amino acid sequence having at least 99% identity with respect to SEQ. ID. No. 61 or SEQ. ID. No. 83; b) subject the sample and probe to rigorous hybridization conditions and b) detect the hybridization of the probe with the DNA of the sample.

27. A method for detecting the presence of a pesticide protein or a fragment thereof in a protein sample, wherein said pesticide protein comprises the amino acid sequence of SEC. ID. No. 61, or SEC. ID. No. 83; or an amino acid sequence having at least 99% identity to CQCLLn / LZnZ / E / Yli with respect to SEC. ID. No. 61 or SEC. ID. No. 83; wherein said method is characterized in that it comprises: i. contacting the sample with an immunoreactive antibody; and ii. detecting the presence of the protein.