AZETIDIN-3-YLMETHANOL DERIVATIVES AS CCR6 RECEPTOR MODULATORS

Abstract

The present invention relates to compounds of Formula (I), their synthesis and use as modulators of the CCR6 receptor for the treatment or prevention of various diseases, conditions or disorders. (see Formula).

Description

[0001] AZETIDIN-3-YLMETHANOL DERIVATIVES AS CCR6 RECEPTOR MODULATORS

[0002] The present invention relates to novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, and their use as CCR6 receptor modulators in the treatment or prevention of various diseases, conditions or disorders ameliorated by modulating said receptor. Furthermore, the present invention concerns related aspects such as pharmaceutical compositions containing one or more compounds of Formula (I) and processes for the preparation of said compounds.

[0003] Chemokine receptors comprise a family G-protein coupled receptors (GPCRs) that recognize and bind to peptide chemokine ligands. The predominant functions of chemokine receptors and their ligands are to induce leukocyte trafficking to-and-from lymphoid organs and tissues in the steady state, as well as in the context of an infection or inflammation. Additionally, chemokine signaling events can induce the activation of integrin molecules on the surface of immune cells, allowing firm adhesion to activated endothelium, facilitating migration from blood into inflamed tissue (Montresor A, Frontiers in Imm., 2012; Meissner A, Blood, 2003). Chemokine receptor 6 (CCR6, aliases BN-1, C-C CKR-6, CD196, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22) is a GPCR mainly expressed on effector CD4+ T helper cells, but is also present on B cells, CD8+ cytotoxic T cells, regulatory T cells (Treg), immature dendritic cells (DC) and type 3 innate lymphoid cells (ILC3) (Cua DJ, Nat Rev Immunol. 2010 Jul; 10(7):479-89. doi: 10.1038 / nri2800). CCR6 binds to the chemokine CCL20 (chemokine (C-C motif) ligand 20) (Greaves DR, J Exp Med. 1997 Sep 15; 186(6):837-44. doi: 10.1084 / jem.186.6.837.). CCL20 is also called macrophage inflammatory protein 3a (MIP-3a), liver and activation-regulated chemokine (LARC), or Exodus-1 (Schutyser E, Cytokine Growth Factor Rev. 2003 Oct; 14(5):409-26. doi: 10.1016 / s1359-6101 (03)00049-2) . CCR6 / CCL20 interactions dictate the humoral response in the intestinal mucosa and are required for lymphocyte homeostasis in the mucosa of the small intestine (Cook DN, Immunity. 2000 May; 12(5):495-503. doi: 10.1016 / s1074-7613(00)80201-0). Under steady state conditions, CCR6 and CCL20 regulate production of IgA in the intestine, where CCL20 expressed in Peyer's patches guides CCR6+lgA+ B cells to the mucosa and secretory IgA can be released into the gut lumen (Lin YL, Front Immunol. 2017; 8:805. doi: 10.3389 / fimmu.2017.00805; Reboldi A, Science. 2016 May 13; 352 (6287) :aaf4822. doi: 10.1126 / science. aaf4822). Under inflammatory conditions, expression of CCL20 is highly upregulated by proinflammatory cytokines including IL-17A, TNFa and IL-1 b in both endothelial and epithelial cells (Harper EG, J Invest Dermatol. 2009 Sep; 129(9):2175-83. doi: 10.1038 / jid.2009.65; PLoS One. 2015; 10(11):e0141710. doi: 10.1371 / journal. pone.0141710) and tissue fibroblasts (Hattori T, Mediators Inflamm. 2015; 2015:436067. doi: 10.1155 / 2015 / 436067). Interleukin (IL)-17A expression is restricted to cells expressing the transcription factor RORgt (Cell. 2006 Sep 22; 126(6): 1121-33. doi: 10.1016 / j.cell.2006.07.035). I L-17A expression has been shown to segregate with CCR6 expression on human T cells (Singh SP, J Immunol. 2008 Jan 1; 180(1):214-21. doi: 10.4049 / jimmunol.180.1 .214; Nat Immunol. 2007 Jun; 8(6):639-46. doi: 10.1038 / ni1467). CCR6 was also described as a target gene of RORgt (PLoS One. 2017; 12(8):e0181868. doi: 10.1371 / journal. pone.0181868; Skepner J, J Immunol. 2014 Mar 15; 192(6):2564-75. doi: 10.4049 / jimmunol.1302190), thus clarifying the co-expression of IL-17A and CCR6 in RORgt+ cell types.

[0004] Certain disclosures in the prior art may be regarded as relating to modulation of CCR6. For instance, Tawaraishia et al. (Bioorganic & Medicinal Chemistry Letters, Volume 28, Issue 18, 2018, Pages 3067-3072, ISSN 0960-894X, https: / / doi.Org / 10.1016 / j.bmcl.2018.07.042) disclose a series of benzenesulfonyl-aminocyclohexane derivatives as selective CCR6 inhibitors. CN103588697 teaches sulfonamide derivatives as CCR6 antagonists and their use in treating CCR6-mediated diseases such as autoimmune diseases, inflammation, psoriasis, multiple sclerosis or cancer. WO2014 / 075580 describes the use of aurintricarboxylic acid for targeting chemokine receptors. WO2015 / 084842 teaches certain sulfonamides which may be used in treating CCR6 related diseases. WO2017 / 087607, WO2010 / 131145, WO2013 / 061004, WO2013 / 061005, WO2019 / 036374 and W02020 / 058869 provide certain cyclobutenediones for use in the treatment of chemokine / CCR6 related diseases. WO2019 / 136370 teaches a method of treating a certain type of psoriasis. WO2019 / 147862 proposes azetidine derivatives which may be used as chemokine modulators.

[0005] Further, W01999 / 43664 discloses certain pyrrolidinones with anti-inflammatory and analgesic properties. In W02019 / 105915 certain heterocyclic compounds are provided which may be used as MAGL inhibitors. WO2015 / 057626, US2015 / 0105366, WO2014 / 062658, W02015 / 057205 and Tanis VM et al. (Bioorg Med Chem Lett. 2019 Jun 15; 29(12): 1463-1470. doi: 10.1016 / j.bmcl.2019.04.021) relate to modulators of the RORyt receptor which may be used in treating rheumatoid arthritis or psoriasis. W003 / 022808 proposes certain azetidine derivatives for use as pesticides. W02008 / 103426 and W02007 / 022351 disclose certain quaternary ammonium compounds useful as muscarinic receptor antagonists. W02006 / 136830 teaches certain heteroaryl-alkylamines as protein kinase inhibitors. W091 / 13359 proposes heterocyclic cholinergic enhancers. US28141 teaches certain pyrrolidines which may be used for treating depression. GB 1304650 discloses spasmolytic pyrrolidines. US3479370, US3489769, US3499002, US 3542807 and US3651085 relate to certain pyrrolidines with analgesic / tranquilizing activity.

[0006] The present CCR6 modulators may be useful, alone, or in combination in the treatment or prevention of the following diseases or disorders: Rheumatoid arthritis (RA) causes chronic inflammation of the joints and chemokines regulate infiltration of the inflamed synovium by inflammatory cells. RA is characterized by the increased release of CCL20 and the subsequent recruitment of CCR6+ T cells to the inflamed joints. CCL20 is highly expressed in the synovial fluid of RA (Hirota, J Exp Med. 2007 Nov 26; 204(12):2803-12. doi: 10.1084 / jem.20071397; Matsui T, Clin Exp Immunol. 2001 Jul; 125(1): 155-61. doi: 10.1046 / j.1365-2249.2001.01542.x). In patients with RA, CCR6+ Th cells have been found in the inflamed synovium and increased proportions of peripheral blood CCR6+ Th cells have been found in patients with early RA (van Flamburg JP, Arthritis Rheum. 2011 Jan; 63(1):73-83. doi: 10.1002 / art.30093; Leipe J Arthritis Rheum. 2010 Oct; 62(10):2876-85. doi: 10.1002 / art.27622; Nistala K, Arthritis Rheum. 2008 Mar; 58(3):875-87. doi: 10.1002 / art.23291 ). The production of CCL20 is known to be up-regulated in synovium explants or fibroblast-like synoviocytes from RA patients after stimulation of TNF-a, IL-1 b and IL-17 (Matsui T, Clin Exp Immunol. 2001 Jul; 125(1): 155-61. doi: 10.1046 / j.1365-2249.2001 .01542.x; J Immunol. 2001 Nov 15; 167(10):6015-20. doi: 10.4049 / jimmunol.167.10.6015; Chevrel G, Ann Rheum Dis. 2002 Aug; 61 (8):730-3. doi: 10.1136 / ard.61.8.730). CCR6+ B cells in RA synovium have been reported, contributing to pathogenesis by antigen presentation, autoantibody production and / or inflammatory cytokine production. Furthermore, Rituximab is an efficacious therapy for RA (Cohen SB, Arthritis Rheum. 2006 Sep; 54(9):2793-806. doi: 10.1002 / art.22025), supporting a role for CCR6+ B cells in RA pathogenesis. Additionally, CCR6-deficient mice have impaired lgG1 -dependent memory B cell responses (J Immunol. 2015 Jan 15; 194(2):505-13. doi: 10.4049 / jimmunol.1401553). Preclinical rodent models showed that CCR6-deficient mice developed a less severe joint inflammation in the collagen-induced arthritis (CIA) model. Reduced production of collagen-specific antibodies in CCR6-deficient mice were observed compared to WT mice, and arthritic inflammation was also reduced (J Cell Mol Med. 2018 Nov; 22(11):5278-5285. doi: 10.1111 / jcmm.13783). Furthermore, depletion of CCR6+ cells reduced the severity of SKG arthritis (Hirota K, J Exp Med. 2007 Nov 26; 204(12):2803-12. doi: 10.1084 / jem.20071397).

[0007] CCR6+ Th17 are increased in peripheral blood in ankylosing spondylitis patients (Shen FI, Arthritis Rheum. 2009 Jun; 60(6): 1647-56. doi: 10.1002 / art.24568). Circulating interleukin-17-secreting interleukin-23 receptor-positive g / d T cells were also reported in patients with active ankylosing spondylitis (Kenna TJ, Arthritis Rheum. 2012 May; 64(5): 1420-9. doi: 10.1002 / art.33507). Secukinumab, an IL-17A inhibitor, in was shown to be efficacious in ankylosing spondylitis (AS) (Baeten D, N Engl J Med. 2015 Dec 24; 373(26):2534-48. doi: 10.1056 / NEJMoal 505066). CD32B expression on memory B cells in AS was increased and was associated with disease activity. Furthermore, CCR6- cytotoxic T-cells and CD32B- memory B-cells were highly enriched within the synovial compartment of AS patients (Sueur A, Clin Exp Rheumatol. 2019 Nov 20; PMID: 31820725).

[0008] Psoriasis is a commonly occurring autoimmune skin disease. The role of Th17-associated cytokines has been clinically validated and their role in psoriatic inflammation confirmed (Paul C, J Eur Acad Dermatol Venereol. 2015 Jun; 29(6): 1082-90. doi: 10.1111 / jdv.12751). An IL-17R-blocking antibody (brodalumab, AMG 827) were shown to reduce clinical manifestations of psoriasis and also to reduce CCL20 expression in skin biopsies from psoriasis patients (Papp KA, N Engl J Med. 2012 Mar 29; 366(13):1181-9. doi: 10.1056 / NEJMoa1109017). Also, an IL-23 neutralizing antibody (guselkumab) was shown to be efficacious in reducing psoriatic inflammation (Reich K, Lancet. 2019 Sep 7; 394(10201):831 -839. doi: 10.1016 / S0140-6736(19)31773-8). CCR6-deficient mice failed to develop psoriasiform skin lesions following intradermal IL-23 injections (Hedrick MN, J Clin Invest. 2009 Aug; 119(8):2317-29. doi: 10.1172 / jci37378). Small molecule CCR6 antagonists have also been shown to be efficacious in the Aldara and IL-36a- injection mouse psoriasis models (Campbell JJ, J Immunol. 2019 Mar 15; 202 (6): 1687- 1692. doi: 10.4049 / jimmunol.1801519; Campbell JJ, J Immunol. 2017 Nov 1; 199(9):3129-3136. doi: 10.4049 / jimmunol.1700826). Furthermore, CCR6-deficient mice have been shown to be protected from imiquimod-induced ear swelling (Yu S, J Invest Dermatol. 2019 Feb; 139(2): 485-488. doi: 10.1016 / j.jid.2018.07.036).

[0009] Anti-CCR6 neutralizing antibodies have also shown efficacy in Aldara induced ear swelling in mice (Robert R, JCI Insight. 2017 Aug 3; 2(15): e94821. Published online 2017 Aug 3. doi: 10.1172 / jci.insight.94821). An engineered disulfide-linked CCL20 dimer, which binds CCR6 but inhibits T cell migration, was shown to reduce skin swelling in an IL-23-dependent mouse model of psoriasis (Getschman AE, Proc Natl Acad Sci U S A. 2017 Nov 21 ; 114(47): 12460- 12465. doi: 10.1073 / pnas.1704958114). Collectively, these data show that a positive feedback consisting of epidermal and dermal production of CCL20, potent recruitment of CCR6+ T cells or into inflamed psoriatic skin, their activation by IL-23 and their expression of IL-17A and IL-22, drives a pathogenic Th17 response in psoriatic skin lesions. Inhibition of CCR6 has therefore been recognized as a potential therapeutic pathway to treat psoriasis (Hedrick MN, Expert Opin Ther Targets. 2010 Sep; 14(9):911-22. doi: 10.1517 / 14728222.2010.504716; Mabuchi T, J Dermatol Sci. 2012 Jan;65(1):4-11. doi: 10.1016 / j . jdermsci .2011.11.007). CCR6 expression was shown to be upregulated in synovial membranes of psoriatic arthritis (PsA) patients (Dolcino M, PLoS One. 2015 Jun 18;10(6):e0128262. doi: 10.1371 / journal. pone.0128262). IL-17A- and GM-CSF-expressing CD4+ T cells isolated from synovial fluid of PsA patients also expressed CCR6 (Al-Mossawi et al., Nat Commun. 2017 Nov 15;8(1):1510. doi: 10.1038 / s41467-017- 01771-2). CCL20 was shown to be highly upregulated in synovial fluid retrieved from PsA patients (Melis L, Ann Rheum Dis. 2010 Mar;69(3):618-23. doi: 10.1136 / ard.2009.107649).

[0010] Additional inflammatory skin disorders including rosacea have been shown to have highly elevated levels of CCL20 in inflamed skin (Buhl T, JID, 2015).

[0011] CCR6 and CCL20 are highly elevated in active Crohn's disease (CD) and ulcerative colitis (UC) (Skovdahl et al., PLoS One. 2015 Nov 4;10(11):e0141710. doi: 10.1371 / journal. pone.0141710). Increased enterocyte CCL20 production has been proposed to play an important role in lymphocyte recruitment to the colonic epithelium in irritable bowel disease (IBD) (Kwon JH, Gut. 2002 Dec; 51 (6):818-26. doi: 10.1136 / gut.51 .6.818). CCL20 and CCR6 expression are also correlated with histological severity in rectum resected from UC patients. CCL20 expression in chronic UC is higher than that in acute UC after pathological examination (Uchida K, Gastroenterol Res Pract. 2015; 2015:856532. doi: 10.1155 / 2015 / 856532). Expression of CCL20 was significantly up-regulated in the PBMCs of patients with UC compared with those of normal healthy controls. UC groups treated with sulfasalazine and GC showed decreases of CCL20 expression in PBMCs, accompanied by ameliorated disease. TNFa or IL-1 b-induced CCL20 secretion was strongly reduced by sulfasalazine and / or GC treatment of human intestinal epithelial cell lines (Lee FI J, 2 Inflamm Bowel Dis. 2005 Dec; 11 (12): 1070-9. doi: 10.1097 / 01. mib.0000187576.26043.ac). CCR6 deficiency resulted in reduced intestinal pathology in mice treated with dextran sodium sulfate (DSS) to induce colonic inflammation (Varona R, Eur J Immunol. 2003 Oct; 33(10): 2937-46. doi: 10.1002 / ej i .200324347) . Th17 cells expressing CCR6 were shown to be important effectors mediating dry eye disease (DED), an inflammatory state at the ocular surface, potentially resulting in corneal perforation. Antibody-mediated neutralization of CCL20 in a DED mouse model reduced Th17 recruitment into the ocular surface, resulting in improved clinical readouts (Dohlman TH, Invest Ophthalmol Vis Sci. 2013 Jun 12; 54(6):4081-91 . doi: 10.1167 / iovs.12-11216). Inhibition of the CCR6 / CCL20 axis was therefore proposed as a therapeutic mechanism to treat DED.

[0012] CCR6 expression has been described on T cells isolated from the cerebrospinal fluid of multiple sclerosis (MS) patients (van Langelaar J, Brain, 2018 May 1; 141 (5): 1334-1349. doi: 10.1093 / brai n / awy069) . CCR6 expression was also shown on T cells infiltrating the inflamed CNS in experimental autoimmune encephalomyelitis (EAE) (Mony JT, Front Cell Neurosci. 2014; 8:187. doi: 10.3389 / f ncel .2014.00187). Furthermore, CCL20 gene polymorphisms have been shown to be associated with MS patient cohorts (El Sharkav et al., Gene. 2019 Feb 15; 685:164-169. doi: 10.1016 / j. gene.2018.11.006). Preclinical data has shown that CCR6 is important for development of EAE (Reboldi A, Nat Immunol. 2009 May; 10(5):514-23. doi: 10.1038 / ni.1716). This finding was confirmed in later study, showing that CCR6-deficient mice were resistant to disease induction with reduced peak severity. In the same study, vaccination with hCCL20 produced an anti-mouse CCL20 response in the host mice, which was sufficient to reduce clinical scores (Abraham M, Clin Immunol. 2017 Oct; 183:316-324. doi: 10.1016 / j. dim.2017.09.018). However, conflicting data exists concerning the role for CCR6 in EAE development (J Neuroimmunol. 2009 Aug 18; 213(1-2):91-9. doi: 10.1016 / j.jneuroim.2009.05.011). EAE severity and histopathology were significantly reduced after injection of anti- CCL20 upon first clinical manifestations (Kohler RE, J Immunol. 2003 Jun 15; 170(12):6298-306. doi: 10.4049 / jimmunol.170.12.6298). Anti-CCR6 neutralizing antibodies were shown to reduce the severity of EAE in mice (Robert R, JCI Insight. 2017 Aug 3; 2(15): e94821. Published online 2017 Aug 3. doi: 10.1172 / jci.insight.94821). IL-6 and IL-17 increase the expression of CCL20 from murine astrocytes (Meares GP, Glia. 2012 May; 60(5):771-81. doi: 10.1002 / glia.22307).

[0013] CCR6 and CCL20 are proposed to influence kinetics of germinal center (GC) formation and B cell responses and CCR6 is considered a marker memory B cell precursors in both mouse and human germinal centers (Suan D, Immunity. 2017 Dec 19; 47(6): 1142-1153.e4. doi: 10.1016 / j.immuni.2017.11.022). Expression of CCR6 on naive, pre-GC, GC / plasma cell and memory B cells in peripheral B cells of systemic lupus erythematosus (SLE) patients was increased (Lee AYS, Clin Rheumatol. 2017 Jun; 36 (6): 1453- 1456. doi: 10.1007 / s10067-017-3652-3). CD4^JCR6+ cells may also contribute to disease severity in SLE patients and were shown to be increased in anti-DNA+ SLE patients, which correlated with disease severity and erythrocyte sedimentation rate (Zhong W, PeerJ. 2018; 6:e4294. doi: 10.7717 / peerj .4294). Increased CCR6 expression in the salivary glands of patients with primary Sjogren's syndrome (pSS) was demonstrated [Scand J Immunol. 2020 Mar;91(3):e12852. doi: 10.1111 / sji.12852], A trend towards increased CCL20 mRNA expression was also observed. Significant reductions in CCR6+ Th cells (both CCR9- and CCR9+) in the circulation of patients with pSS as compared with healthy controls (HCs) were demonstrated [Scand J Immunol. 2020 Mar; 91 (3) :e 12852. doi: 10.1111 / sji.12852],

[0014] In an animal model of autoimmune hepatitis (AIH), administering anti-TNF-a suppressed hepatic CCL20 expression. Mice receiving anti-CCL20 showed reduced AIH. Furthermore, TNFa stimulation enhanced CCL20 expression in hepatocytes. These findings suggest that TNFa is essential in the induction of AIH through upregulation of hepatic CCL20 expression, which recruits CCR6+ T cells which drive pathology (Clin Immunol. 2013 Jan; 146(1): 15-25. doi: 10.1016 / j.clim.2012.10.008).

[0015] The present CCR6 modulators may be useful, alone, or in combination in the treatment or prevention of autoimmune diseases or disorders including Posterior uveitis, allergic conjunctivitis, allergic disease in the gastrointestinal tract, type I diabetes and endometriosis (Medicina (Kaunas). 2018 Nov 16; 54(5). doi: 10.3390 / medicina54050088). CCR6 modulators may also be useful, alone or in combination, to treat diseases of the ocular surface in which elevated levels of IL-17A have been recorded, including meibomian gland dysfunction; GVHD, graft-versus host disease; autoimmune keratitis, filamentary keratitis, dry eye syndrome with rheumatic arthritis; dry eye syndrome without systemic disease; Stevens-Johnson syndrome. (J Korean Med Sci. 2011 J u I ; 26 (7) : 938-44. doi: 10.3346 / jkms.2011 .26.7.938).

[0016] The present CCR6 modulators may be useful, alone, or in combination in the treatment or prevention of malignant diseases. Modulation of the CCR6 / CCL20 axis using siRNA, shRNA, CCR6 knock-out animals, CCL20 ligand treatment or antibodies has been shown to alter tumor growth and metastatic processes in experimental disease models as single agents, or in combination with immunotherapy (such as especially PD1 and / or PDL1 blockade) for the prevention / prophylaxis or treatment of cancers.

[0017] The therapeutic potential of modulating this axis for the treatment of malignancies has been described in tumor mouse models using small interfering RNA (siRNA) or small hairpin RNA (shRNA)-mediated silencing of CCR6 or CCL20. Specifically, in a mouse model of cutaneous T cell lymphoma (My-La cells), Abe et al. reported that the administration of a CCR6-targeted siRNA prolonged survival of animals when compared with control animals (Oncotarget. 2017 Jan 31; 8(5)7572-7585. doi: 10.18632 / oncotarget.13810.). Using another approach, Ito and colleagues demonstrated that mice, injected with T lymphoma cells (My-La) harboring a CCR6 silencing siRNA construct, survived significantly longer than mice injected with control cells (Blood. 2014 Mar 6; 123(10): 1499-511 . doi: 10.1182 / blood-2013-09-527739.). Zhu and co-workers demonstrated that, the average volume and weight of tumor nodules in mice injected subcutaneously with a set of colorectal cancer cell lines was decreased when CCR6 was silenced in the cancer cells by means of shRNA (PMID Biochim Biophys Acta Mol Basis Dis. 2018 Feb; 1864(2): 387-397. doi: 10.1016 / j.bbadis.2017.10.033.). In glioblastoma xenograft models using patient-derived glioblastoma cell lines, mice injected with cells harboring a shRNA construct silencing CCR6 expression survived longer than those injected with control cells. In addition, histology and immunohistochemistry revealed that tumors formed by glioma cells with CCR6-targeting shRNA were much smaller, and tumor vessel formation was significantly lower versus control tumors. Collectively, these data further support the notion that CCR6 signaling enhances the oncogenic potential of malignancies including lymphoma, colorectal tumors and glioblastoma (Oncogene. 2018 Jun; 37(23): 3070-3087. doi: 10.1038 / s41388-018-0182-7. ) . Specifically, the implication of the CCR6 / CCL20 axis in tumorigenesis using CCR6 knock-out animals was reported in the literature. In the CMT93 mouse model of colorectal cancer (CRC), the infiltration of T regulatory cells was completely prevented in tumors of mice deficient in CCR6 in comparison to wildtype animals. The reported data further suggest that the homing and trafficking of tumor-infiltrating T regulatory cells to the tumor mass is dependent on the chemokine receptor CCR6 in vivo (PLoS One. 2011 Apr 29; 6(4):e19495. doi: 10.1371 / journal. pone.0019495.). According to Nandi and colleagues, in a mouse model of spontaneous intestinal tumorigenesis [APCMIN / + mice, heterozygous for a mutation in the adenomatous polyposis coli (APC) gene], mice deficient in CCR6 had a lower occurrence of spontaneous intestinal tumorigenesis (PLoS One. 2014; 9(5):e97566. doi: 10.1371 / journal .pone.0097566.).

[0018] The potential role of the CCR6 / CCL20 axis in tumorigenesis was also demonstrated by administrating the recombinant CCL20 chemokine. Specifically, in a mouse model of colorectal cancer (CMT93 cells), Liu and colleagues showed that tumor size was significantly increased in mice treated with recombinant mouse CCL20 compared with PBS controls, suggesting a critical role for CCL20 in colorectal cancer growth and development (PLoS One. 2011 Apr 29; 6(4):e19495. doi: 10.1371 / journal. pone.0019495.).

[0019] Specifically, using neutralizing CCL20 antibodies, the potential role of the CCR6 / CCL20 axis in tumor promotion was demonstrated in the literature using mouse models. Ikeda and co-workers used a specific cutaneous T cell lymphoma (CTCL) mouse model in which animals succumb to metastasis of CTCL cells into multiple organs. However, administration of a neutralizing CCL20 antibody significantly prolonged the survival of the xenografted mice (Oncotarget. 2016 Mar 22; 7(12):13563-74. doi: 10.18632 / oncotarget.6916.). Lee and co-workers described in a mouse model of metastatic breast cancer (MDA-MB-231 cells were injected into the left cardiac ventricles of nude mice) that the administration of an anti-CCL20 antibody prevented the development of bone metastasis, one of the major site of breast cancer metastasis in human disease (Sci Rep. 2017 Aug 29; 7(1):9610. doi: 10.1038 / s41598-017-09040-4.). In a humanized mouse model of nasopharyngeal carcinoma, Mrizak et al. observed a significant decrease of T regulatory cell recruitment into the tumor when mice were injected with anti-CCL20 monoclinal antibody in comparison to sham treated animals (J Natl Cancer Inst. 2015 Jan; 107(1):363. doi: 10.1093 / jnci / dju363.). In addition, in a mouse model of hepatocarcinoma (Hepa1-6 cells), blockade of CCL20 activity in immunocompetent mice using an anti-CCL20 antibody, attenuated tumor incidence, restrained tumor growth and distal metastasis. Moreover, the authors reported that in this mouse model, tumor angiogenesis was significantly inhibited upon CCL20 neutralization. (He at al., PMID 28560063 - Am J Cancer Res. 2017; 7 (5) : 1151-1163.). Using the same mouse model, the administration of the anti-CCL20 neutralizing antibody remarkably reduced the infiltration of T regulatory cells into the tumor, especially CCR6 positive T regulatory cells, and significantly decreased tumor growth. Antitumor efficacy was further enhanced when the mice were co-treated with an anti-PDL-1 antibody. Collectively these data sets suggest that CCL20 blockade could abrogate anti-PD-L1 resistance in a mouse model of hepatocarcinoma by inhibiting T regulatory recruitment to the tumor (Hepatology. 2019 Jul; 70(1): 198-214. doi: 10.1002 / hep.30593.).

[0020] Specifically, the potential role of the CCR6 / CCL20 axis in tumor metastasis was described in the literature. Dellacasagrande and colleagues reported that, in a mouse model of plasmacytoma, tumor cells that disseminated to the liver overexpressed functional CCR6 in comparison with tumor cells of the primary tumor (from s.c. injection of mouse plasmacytoma (MOPC315)). The same authors found that CCR6 was overexpressed in small liver metastases of colon, thyroid and ovarian carcinomas compared with normal liver (Scand J Immunol. 2003 Jun; 57(6):534-44. doi : 10.1046 / j .1365-3083.2003.01263.x.).

[0021] Furthermore, the present CCR6 modulators may be useful, alone, or in combination in the treatment or prevention of cancers where the expression of CCR6 and / or CCL20 correlates with disease progression and resistance to standard treatment care. Specifically, the correlation of CCR6 expression with disease progression was described in the literature for numerous cancer indications. For example, in renal cell carcinoma CCR6 expression is associated with a lower overall survival (Cancers (Basel). 2019 Dec 30; 12(1). doi: 10.3390 / cancersl 2010089.). In colorectal cancer, tumor expression of CCR6 positively correlates with metastasis and upregulated CCR6 predicts poor survival, shorter disease- free survival (PLoS One. 2014; 9(6):e101137. doi: 10.1371 / journal. pone.0101137.), and poorer 5-year overall survival (Biochim Biophys Acta Mol Basis Dis. 2018 Feb; 1864(2):387-397. doi: 10.1016 / j.bbadis.2017.10.033.). In ovarian cancer high CCR6 mRNA expression was also associated with a worse prognosis (Cancer Lett. 2020 Mar 1; 472:59- 69. doi: 10.1016 / j. can let.2019.12.024.). CCR6 expression was associated with rectal cancer aggressiveness, indeed, high-level expression of CCR6 protein was more common in non-responders to radiotherapy than in responders (Cancer Res Treat. 2018 Oct; 50(4) : 1203- 1213. doi: 10.4143 / crt.2017.538.). The expression level of CCR6 in prostate cancer was associated with clinical and pathologic features of more advanced and aggressive disease (J Cancer Res Clin Oncol. 2008 Nov; 134(11):1181-9. doi: 10.1007 / s00432-008-0403-5. ) . In non-small cell lung cancer (NSCLC) high CCR6 expression was associated with shorter disease-free survival and conferred a disease stage-independent 5-fold increased risk for disease recurrence (PLoS One. 2011; 6(9):e24856. doi: 10.1371 / journal. pone.0024856.). Hepatocarcinoma patients with increased infiltrated CCR6 positive immune cells in tumor tissues showed a poorer prognosis (Am J Cancer Res. 2017; 7(5): 1151-1163.).

[0022] Analogous to CCR6, expression of its ligand CCL20 has been reported to correlate with poorer disease outcome for several indications. Specifically, in breast cancer, elevated CCL20 expression significantly correlated with lower overall free survival, lower percent metastasis free survival (Sci Rep. 2017 Aug 29; 7(1):9610. doi: 10.1038 / s41598-017- 09040-4.), with higher histological grade, higher Ki67 index, and axillary lymph node metastases. Moreover, breast tumor CCL20 expression positively correlated with expression of FOXP3, a marker of T regulatory cells. Patients with axillary lymph node metastases, and concomitant elevation in CCL20 expression and FOXP3-positive T regulatory cells, had the worst overall survival. (Medicine (Baltimore). 2019 Dec; 98(50):e18403. doi: 10.1097 / M D.0000000000018403.). In NSCLC higher expression of CCL20 was associated with a lower overall survival (Biomed Pharmacother. 2015 Feb; 69:242-8. doi: 10.1016 / j.biopha.2014.12.008.)(Cancer Lett. 2015 Jul 10; 363(1):60-70. doi: 10.1016 / j.canlet.2015.04.005.). Analogous to NSCLC, hepatocellular carcinoma patients with high CCL20 expression had poorer overall survival and poorer recurrence-free survival. The same authors described that CCL20 expression was significantly associated with tumor size, tumor number, vascular invasion, tumor differentiation and tumor recurrence (J Gastrointest Surg. 2012 Apr; 16(4):828-36. doi: 10.1007 / s11605-011-1775-4.). In addition to CCR6 or CCL20 alone, correlation of CCR6 / CCL20 co-expression with disease progression is stated in literature. Indeed, overexpression of both, CCL20 and CCR6, was detected in high-grade glioma tissues as compared to low-grade tissues and increased with ascending tumor World Health Organization (WHO) grades. Particularly glioma patients with CCL20 / CCR6 co-expression had the shortest overall survival (Med Oncol. 2012 Dec; 29(5):3491-7. doi: 10.1007 / s 12032-012-0314-9.).

[0023] Besides, CCR6 and / or CCL20 expression correlates with enhance chemotherapeutic resistance and is associated with metastasis. Indeed, CCL20 expression can increase the chemotherapeutic resistance of breast cancer cells (PLoS Biol. 2018 Jul; 16(7):e2005869. doi: 10.1371 / journal. pbio.2005869.). Rubie and colleagues describe that in colorectal liver metastases (CRLM) and in human samples of hepatocellular carcinoma (HCC), significant up-regulation of CCL20 / CCR6 was detected (RT-PCR). Moreover, CCL20 was significantly overexpression in colorectal liver metastases as compared to the primary HCC, indicating an involvement of the CCL20 / CCR6 ligand-receptor pair in the carcinogenesis and progression of hepatic malignancies (World J Gastroenterol. 2006 Nov 7; 12(41):6627-33. doi: 10.3748 / wjg.v12.Ϊ41 .6627.).

[0024] The present CCR6 modulators may be useful, alone, or in combination in the treatment or prevention of diseases or disorders where CCR6 and / or CCL20 are expressed or overexpressed in patient samples or cancer cell lines. Specifically, the chemokine receptor CCR6 is described to be expressed in several cancer types or cancer cell lines in the literature. Lu and coworkers describe that CCR6 expression was higher in laryngeal cancer tissues compared with their normal controls. The authors reported that CCR6 was also expressed in commonly used laryngeal cancer cells such as TU212, M4E, M2E and Hep-2 (Biomed Pharmacother. 2017 Jan; 85:486-492. doi: 10.1016 / j.biopha.2016.11.055.). Based on gene expression data from malignant melanoma, among the biological networks reported CCR6 gene was described and characterized as a valuable factor involved in immune responses and tumor progression (PLoS One. 2018; 13(1 ):e0190447. doi: 10.1371 / journal. pone.0190447.) Whole exome sequencing in 21 MALT lymphomas of the salivary gland and thyroid revealed that CCR6 was expressed (Haematologica. 2018 Aug; 103(8): 1329-1336. doi: 10.3324 / haematol.2018.191601.). In samples of adult human T-cell leukemia / lymphoma (ATLL) transcripts of CCR6 were detected, and CCR6 was further found at the protein level using flow cytometric analysis (Leuk Lymphoma. 2006 Oct; 47(10):2163-73. doi: 10.1080 / 10428190600775599.). In patient- derived prostate cancer samples the gene expression of CCR6 (mRNA) was significantly higher in tumor tissue as compared to adjacent normal tissue (Cancer Res Treat. 2015 Apr; 47(2):306-12. doi: 10.4143 / crt.2014.015.). CCR6 expression was detected in commonly used cancer cell lines, indeed, according to Mays and co-workers, in salivary adenoid cystic carcinoma cells SACC-83, among other CC chemokine receptors, CCR6 was expressed using RT-PCR gene analysis (Anticancer Res. 2016 Aug; 36 (8): 4013-8.). According to Moller and colleagues, in multiple myeloma (MM) cell lines including U266 1970, U-266 1984, U-1958, Karpas 707, LP-1,28 L-363, HL407E and HL407L.3, CCR6 was also expressed (Leukemia. 2003 Jan; 17(1):203-10. doi: 10.1038 / sj. leu.2402717.).

[0025] Analogous to CCR6, the ligand CCL20 was reported to be expressed in multiple tumor samples and tumor cell lines in the literature. For example, Zhang and co-workers demonstrated that in samples from NSCLC patients, using RT-PCR, CCL20 showed higher expression in tumor samples than in samples of adjacent tissue, this was also verified at the protein level using immunohistochemistry (Biomed Pharmacother. 2015 Feb; 69:242-8. doi: 10.1016 / j.biopha.2014.12.008.). Gene expression analysis of cholangiocarcinoma samples and corresponding normal tissue revealed CCL20 to be one of the genes most significantly over-expressed in malignant vs healthy tissue (EXCLI J. 2020; 19:154-166. doi: 10.17179 / excli2019-1893.). CCL20 expression was also reported in multiple myeloma (MM) human samples (Cancer Res. 2008 Aug 15; 68(16):6840-50. doi: 10.1158 / 0008-5472. CAN-08-0402.). Besides, according to Rubies et al., CCL20 mRNA and protein was significantly up-regulated in pancreatic carcinoma (8-fold) as compared to matched normal pancreas in which CCL20 was weakly expressed (J Transl Med. 2010 May 10; 8:45. doi: 10.1186 / 1479-5876-8-45.). .). CCL20 is also expressed in oral squamous cell carcinoma (IHC staining) and Lee et al. reported that expression is enriched in human CCR6+ regulatory T cells with superior suppressive activity (J Immunol. 2017 Jul 15; 199 (2): 467-476. doi: 10.4049 / jimmunol.1601815.).

[0026] In addition to CCR6 or CCL20 alone, the co-expression of both CCR6 and CCL20 is reported for samples of cancer patients and cancer cells lines in literature. Both genes have been described to be expressed in adult T-cell leukemia / lymphoma patient samples (Microarray and IHC protein staining) (Int J Oncol. 2014 Sep; 45(3):1200-8. doi: 10.3892 / ijo.2014.2524.) and in CTCL. In the latter, CCL20 and CCR6 were detected at the mRNA and protein levels (Clin Cancer Res. 2011 Dec 15; 17(24)7529-38. doi: 10.1158 / 1078-0432. CCR-11-1192.). Transcriptomic analysis (nanostring) of samples of hepatocellular carcinoma revealed CCR6 and CCL20 expression. Moreover, a chemotactic gradient between non-tumor and tumor tissues was reported and a recruitment process of T regulatory cells, tumor associated macrophages and natural killer cells involving the CCR6 / CCL20 axis suggested (Proc Natl Acad Sci U S A. 2017 Jul 18; 114(29): E5900-E5909. doi: 10.1073 / pnas.1706559114.). Similarly, Guo and co-workers reported CCR6 and CCL20 upregulation in hepatocarcinoma lesions compared to healthy tissue as well as CCR6 and CCL20 expression in hepatocarcinoma cell lines (L02, Li- / , Huh-7, SNU-387, Hep3B) (Oncol Rep. 2019 Sep; 42(3): 1075-1089. doi: 10.3892 / or.2019.7221 .). In human colorectal cancer, both CCL20 and CCR6 are expressed according to Nandi et al. (IHC protein staining). Both, CCR6 and CCL20, were found to be highly expressed in samples of NSCLC (protein and mRNA) (Oncol Lett. 2017 Dec; 14(6):8183-8189. doi: 10.3892 / ol .2017.7253) . Using in situ hybridization, both CCL20 and CCR6 mRNA moieties were strongly expressed in all pancreatic cancer samples analysed. In contrast, in healthy pancreas CCL20 and CCR6 expression was low (Int J Cancer. 1999 May 17; 81 (4):650-7. doi: 10.1002 / (sici)1097-0215(19990517)81 :4<650::aid-ijc23>3.0.co;2-#.). Jin and co-workers examined CCR6 and CCL20 expression in glioblastoma using publicly available datasets. The authors used the GEO dataset GSE2223 to compare the mRNA levels of CCL20 and CCR6, between normal brain and glioblastoma tissues. Again, CCR6 and CCL20 expression levels were significantly higher in glioblastoma tissues than in normal brain tissues (Oncogene. 2018 Jun; 37(23) :3070-3087. doi : 10.1038 / s41388-018-0182-7. ). In addition, Wallace and colleagues observed that in endometrial adenocarcinoma explants and cell lines, expression of CCL20 and its receptor CCR6 were higher compared to non-malignant endometrium (mRNA, RT-PCR) (Mol Cell Endocrinol. 2011 Jan 1; 331 (1): 129-35. doi: 10.1016 / j.mce.2010.08.018.). CCL20 / CCR6 axis may play a role in breast cancer, cholangiocarcinoma, and thyroid cancer since expression of CCR6 / CCL20 genes and / or proteins was reported in patient derived breast cancer cells (Mol Carcinog. 2016 Jul; 55(7): 1175-86. doi: 10.1002 / mc.22360.), in HuCCTI and TFK-1 cholangiocarcinoma cell lines () (Win et al., PMID 32194362 ) (EXCLI J. 2020; 19:154-166. doi: 10.17179 / excli2019-1893.) and thyroid cancer cell lines such as TPC-1, BCPAP, FTC-133, and SW1736 (Tumour Biol. 2016 Apr; 37 (4): 5569-75. doi: 10.1007 / s 13277- 015-4418-7.). Furthermore, the present CCR6 modulators may be useful, alone, or in combination in the treatment or prevention of cancers where the expression and / or evidence of CCR6 / CCL20 axis activity has been reported, or where CCR6+ regulatory T cells have been identified inside the tumor microenvironment.

[0027] 1) One aspect of the present invention relates to compounds of Formula (I), wherein

[0028] Formula (I)

[0029] A represents a 6-membered heteroaryl containing from one to three ring nitrogen atom(s) (notably one or two ring nitrogen atoms; especially one or two ring nitrogen atoms in n?efa-position(s) and / or para- position of A with respect to the point of attachment of A to the rest of the molecule), wherein said 6-membered heteroaryl is independently unsubstituted, mono-, di- or tri-substituted (notably mono- or di-substituted in meta- and / or para- position of A with respect to the point of attachment of A to the rest of the molecule), wherein the substituent(s), if any, is(are) independently selected from

[0030] • halogen (especially fluorine);

[0031] • cyano;

[0032] • hydroxy-Ci-6-alkyl which is optionally further substituted with one to three fluorine atoms (wherein notably the hydroxy group is separated from any one fluorine atom by at least two carbon atoms; especially such hydroxy- Ci-6-alkyl represents 3-hydroxy-propyl, 4-hydroxy-butyl, 3-hydroxy-butyl, 3-hydroxy-3-methyl-butyl, 3-hydroxy- 4-methyl-pentyl, 3-hydroxy-3-trifluoromethyl-butyl, or 2,2-difluoro-3-hydroxy-prop-1-yl);

[0033] • Ci_5-alkyl (notably methyl, ethyl, propyl, isopropyl, butyl, or isobutyl) which is unsubstituted or mono-substituted with

[0034] > Ci-3-alkoxy (especially methoxy);

[0035] > C3-6-cycloalkyl which is optionally fused with a pyridine ring (notably at positions 2 and 3 adjacent to the nitrogen atom of said pyridine ring), wherein said C3-6-cycloalkyl is unsubstituted or mono- substituted with hydroxy (notably at the point of attachment of the C3-6-cycloal kyl to the C -alkyl);

[0036] > -O-R01, wherein R01represents C3-6-cycloalkyl (especially cyclopentyl) or pyrrolidinyl (especially pyrrolidin-2-yl) which is independently unsubstituted or mono-substituted with Ci_3-alkyl (especially methyl) or Ci-4-al kyl-carbonyl (especially acetyl);

[0037] > phenyl— L1—, wherein said phenyl is unsubstituted or mono-substituted with fluorine, Ci_4-alkoxy- carbonyl (especially methoxy-carbonyl), or hydroxy-Ci_4-alkyl (especially hydroxy-methyl); wherein - L1- represents a bond (i.e. the phenyl is attached directly to said alkyl), oxygen (i.e. the phenyl is attached via oxygen to said alkyl), or the group -CH2-O- (wherein the phenyl is attached to the methylene group);

[0038] > C4-6-heterocyclyl containing one or two ring heteroatoms independently selected from nitrogen and oxygen (notably azetidinyl, imidazolidinyl, pyrrolidinyl, oxazolidinyl, piperidinyl, or tetrahydropyranyl; especially azetidin-3-yl, tetrahydropyran-4-yl, imidazolidin-1-yl, pyrrolidin-1-yl, oxazolidin-3-yl, pyrrolidin-2-yl, pyrrolidin-3-yl, piperidin-4-yl), wherein said C4-6-heterocyclyl is unsubstituted, mono-, or di-substituted with oxo, hydroxy, Ci_3-alkyl (especially methyl), Ci_4-alkyl-carbonyl (especially acetyl), or Ci.4-alkoxy-carbonyl (especially tert-butoxy-carbonyl);

[0039] [in particular such C4-6-heterocyclyl represents 1-(tert-butoxy-carbonyl)-3-hydroxy-azetidin-3-yl, tetrahydropyran-4-yl, 4-hydroxy-tetrahydropyran-4-yl, 2-oxo-imidazolidin-1-yl, 2-oxo-3-methyl- imidazolidin-1-yl, 2-oxo-pyrrolidin-1-yl, 2-oxo-oxazolidin-3-yl, 2-oxo-oxazolidin-3-yl, N-acetyl-2- methyl-pyrrolidin-2-yl, N-(tert-butoxy-carbonyl)-3-hydroxy-pyrrolidin-3-yl, N-acetyl-piperidin-4-yl, or N-(tert-butoxy-carbonyl)-piperidin-4-yl]

[0040] > 5-membered heteroaryl containing one or two ring nitrogen atoms (notably pyrazolyl; especially pyrazol-4-yl), wherein said 5-membered heteroaryl is unsubstituted or mono-substituted with Ci_3- alkyl (especially methyl);

[0041] > -NRN1RN1wherein RN1represents hydrogen and RN2represents C 1 _3-al kyl-carbonyl (especially acetyl) or hydroxy-Ci-3-alkyl-carbonyl (especially hydroxymethyl-carbonyl) [in particular such -NRN1RN2represent acetyl-amino or hydroxymethyl-carbonyl-amino]; > indolyl (especially indol-2-yl);

[0042] > pyrrolopyridinyl (especially 1H-pyrrolo[2,3-b]pyridin-2-yl));

[0043] > N-(Ci-3-alkyl)-amino-carbonyl-oxy; or

[0044] > 1 -hydroxy-1- C3-5-cycloalkyl-1-(pyridinyl)-methyl (especially 1 -hydroxy-1 -cyclopropyl-1 -(pyridin-2-yl)- methyl);

[0045] [in particular such C -alkyl represents methyl, ethyl, isopropyl, cyclopentyl-oxy-methyl, 2-(1-hydroxy- cyclopropyl)-ethyl, 2-(1-hydroxy-cyclobutyl)-ethyl, 2-(1-hydroxy-cyclopentyl)-ethyl, 3-methoxy-propyl, 4-fluoro- phenoxy-methyl, 2-(2-(methoxy-carbonyl)-phenyl)-ethyl, benzyl-oxy-methyl, N-(isopropyl)-amino-carbonyl- oxy-methyl, 2-(1-(tert-butoxy-carbonyl)-3-hydroxyazetidin-3-yl)-ethyl, 3-methyl-3-(2-oxo-imidazolidin-1-yl)- butyl, 3-methyl-3-(2-oxo-3-methyl-imidazolidin-1-yl)-butyl, 3-methyl-3-(2-oxo-pyrrolidin-1-yl)-butyl, 2-(N-(tert- butoxy-carbonyl)-3-hydroxy-pyrrolidin-3-yl)-ethyl, 3-methyl-3-(2-oxo-oxazolidin-3-yl)-butyl, 2-(1 -methyl-1 H- pyrazol-4-yl)-ethyl, 2-(2-hydroxymethyl-phenyl)-ethyl, 2-(tetrahydropyran-4-yl)-ethyl, 2-(4-hydroxy- tetrahydropyran-4-yl)-ethyl, 2-(indol-2-yl)-ethyl, 2-(8-hydroxy-5,6,7,8-tetrahydroquinolin-8-yl)-ethyl, 2-(7- hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl)-ethyl, 2-(N-acetyl-piperidin-4-yl)-ethyl, 2-(N-(tert-butoxy- carbonyl)-piperidin-4-yl)-ethyl, N-acetyl-2-methyl-pyrrolidin-2-yl-oxy-methyl, acetyl-amino-isopropyl, N- (hydroxymethyl-carbonyl)-amino-methyl, 3-hydroxy-3-cyclopropyl-3-(pyridin-2-yl)-propyl, 2-(indol-2-yl)-ethyl, or 2-(1 H-pyrrolo[2,3-b]pyridin-2-yl)-ethyl]

[0046] • C3-5-alkyl (especially n-propyl, n-butyl, or n-pentyl) which is substituted with hydroxy and RA1, wherein said substituents are both at position 3 with respect to the point of attachment of said C3-s-alkyl to the rest of the molecule; wherein

[0047] > RA1represents

[0048] ■tetrahydropyranyl (especially tetrahydropyran-4-yl);

[0049] ■phenyl which is unsubstituted or mono-substituted with fluorine (especially 3-fluoro-phenyl) or Ci-3-alkoxy (especially 2-methoxy-phenyl or 4-methoxy-phenyl);

[0050] ■5- or 6-membered heteroaryl containing one or two ring heteroatom(s) being independently selected from nitrogen or sulfur (notably thiazolyl, pyrazolyl, pyridinyl, pyrazinyl, or pyrimidinyl; especially thiazol-4-yl, thiazol-5-yl, pyrazol-3-yl, pyrazol-4-yl, pyridin-2-yl, pyridin-3-yl, pyrimidin-2-yl, pyrazin-2-yl, or pyrimidin-4-yl), wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono- or di- substituted, and wherein the substituent(s), if any, is(are) independently selected from Ci_3-alkyl (especially methyl), Cs s-cycloalkyl (especially cyclopropyl), or Ci.3-alkoxy (especially methoxy); or

[0051] ■indazolyl (especially indazol-3-yl); [in particular such C3-5-alkyl which represents 3-hydroxy-3-(tetrahydropyran-4-yl)-propyl, 3-hydroxy-3-phenyl- propyl, 3-hydroxy-3-phenyl-butyl, 3-hydroxy-3-(3-fluoro-phenyl)-butyl, 3-hydroxy-3-(2-methoxy-phenyl)-butyl,

[0052] 3-hydroxy-3-(4-methoxy-phenyl)-butyl, 3-hydroxy-3-(1,5-dimethyl-pyrazol-3-yl)-butyl, 3-hydroxy-3-(1-methyl- pyrazol-3-yl)-butyl, 3-hydroxy-3-(1 -cyclopropyl- 1 H-pyrazol-3-yl)-butyl, 3-hydroxy-3-(1,5-dimethyl-pyrazol-3- yl)-propyl, 3-hydroxy-3-(2-methyl-thiazol-4-yl)-butyl, 3-hydroxy-3-(2-methyl-thiazol-5-yl)-butyl, 3-hydroxy-3-(6- methoxy-pyridin-2-yl)-butyl, 3-hydroxy-3-(5-methyl-pyridin-3-yl)-butyl, 3-hydroxy-3-(pyridin-2-yl)-butyl, 3- hydroxy-3-(6-methyl-pyridin-2-yl)-butyl, 3-hydroxy-3-(pyrimidin-2-yl)-butyl, 3-hydroxy-3-(6-methoxy-pyrimidin-

[0053] 4-yl)-butyl, 3-hydroxy-3-(6-methyl-pyrimidin-4-yl)-pentyl, 3-hydroxy-3-(2-methyl-pyrimidin-4-yl)-butyl, 3- hydroxy-3-(5-methyl-pyrazin-2-yl)-butyl, 3-hydroxy-3-(1 H-indazol-3-yl)-butyl, 3-hydroxy-3-(1 ,3-dimethyl- pyrazol-4-yl)-propyl, 3-hydroxy-3-(2-methyl-thiazol-4-yl)-propyl, 3-hydroxy-3-(pyridin-2-yl)-pentyl, or 3- hydroxy-3-(6-methoxy-pyridin-2-yl)-pentyl]

[0054] • C3-5-alkenyl which is unsubstituted (especially isopropenyl) or mono-substituted with hydroxy (especially 4- hydroxy-but-1 -en-2-yl);

[0055] • C4-6-cycloalkenyl (notably cyclopentenyl; especially cyclopent- 1 -en- 1 -y I) which is unsubstituted, mono-, or di- substituted with Ci-3-alkyl, oxo, or hydroxy; wherein optionally one ring carbon atom of said C4-6-cycloalkenyl is replaced by an oxygen atom;

[0056] [in particular such C4-6-cy cl o al ke ny I represents cyclopent-1-en-1-yl, 3-oxo-cyclopent-1-en-1-yl, 3-hydroxy- cyclopent-1 -en-1 -yl, 3-hydroxy-3-methyl-cyclopent-1 -en-1 -yl, or 2,3-dihydro-furan-3-yl]

[0057] > C3-6-cycloalkyl which is unsubstituted, mono-, or di-substituted with Ci-3-alkyl (especially methyl, ethyl, isopropyl), hydroxy or hy droxy-Ci -3-al ky I (especially 1 -hydroxy-1 -methyl-ethyl), wherein optionally one ring carbon atom of said C3-6-cycloalkyl is replaced by an oxygen atom;

[0058] [in particular such C3-6-cycloalkyl represents cyclopropyl, cyclopentyl, 3-hydroxy-cyclopentyl, 3-hydroxy-3- methyl-cyclopentyl, 3-hydroxy-3-ethyl-cyclopentyl, 3-hydroxy-3-isopropyl-cyclopentyl, 2-(2-hydroxy- isopropyl)-cyclopropyl, 4-hydroxy-cyclohexyl, 4-hydroxy-4-methyl-cyclohexyl, oxetan-3-yl, tetrahydrofuran-3- yl, tetrahydrofuran-2-yl, tetrahydropyran-4-yl, 5-methyl-tetrahydrofuran-2-yl, or 5,5-dimethyl-tetrahydrofuran- 2-yl]

[0059] > -O-R02, wherein

[0060] > R02represents

[0061] ■Ci-4-alkyl (especially methyl, ethyl, isopropyl, sec-butyl, or isobutyl);

[0062] ■C2-5-alkyl which is mono-substituted with hydroxy or Ci_3-alkoxy (especially methoxy);

[0063] [in particular such C2-5-alkyl represents 2-hydroxy-ethyl, 3-hydroxy-propyl, 2-hydroxy-2- methyl-propyl, 3-hydroxy-3-methyl-butyl, or 2-methoxy-ethyl]■-L2-CY2, wherein

[0064] ❖ -L2- independently represents a bond (i.e. the CY2is directly attached to the rest of the molecule), -CH2-, or -CH2-CH2-; and

[0065] ❖ CY2independently represents o phenyl which is unsubstituted or mono-substituted with hydroxy-Ci-3-alkyl (especially 2-hydroxy-ethyl); o benzyl-oxy; o 5- to 6-membered heteroaryl containing one to three ring heteroatom(s) being independently selected from nitrogen, oxygen, or sulfur (notably pyridinyl, oxadiazolyl, or triazolyl); especially pyridin-2-yl, 1,2,4-oxadiazol- 5-yl, or 1,2,4-triazol-1-yl), wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono- or di- substituted; wherein the substituent(s), if any, is(are) independently selected from Ci_3-alkyl (especially methyl) or Ci-3-cycloalkyl (especially cyclopropyl); o C3-6-cycloalkyl, wherein optionally one carbon ring atom is replaced by one heteroatom selected from oxygen and nitrogen (especially oxetanyl, cyclopentyl or cyclohexyl); wherein said C3-6-cycloalkyl is unsubstituted, mono-, or di-substituted, wherein the substituents are selected from C1-3- alkyl (especially methyl), hydroxy, fluoro, oxo, Ci-3-alkyl-carbonyl (especially acetyl), and Ci.3-alkoxy (especially methoxy); o benzooxazolonyl (especially 3H-benzooxazol-2-on-6-yl); o chromanyl (especially chroman-6-yl);

[0066] [in particular such -L2-CY2represents phenyl, 4-(2-hydroxy-ethyl)-phenyl, 2-(2-hydroxy- ethyl)-phenyl, benzyl, 2-(benzyl-oxy)-ethyl, 2-(pyridin-2-yl)-ethyl, 3-cyclopropyl-1 ,2,4- oxadiazol-5-yl-methyl, 2-(3,5-dimethyl-1,2,4-triazol-1-yl)-ethyl, oxetan-3-yl-methyl, 2,2- dimethyl-cyclopentyl, 3,3-difluoro-cyclopentyl, 3-methoxy-cyclopentyl, cyclohexyl, 4- hydroxy-cyclohexyl, 4-methyl-4-hydroxy-cyclohexyl, 4-oxo-cyclohexyl, tetrahydrofuran-3-yl, tetrahydropyran-4-yl, tetrahydropyran-4-yl-methyl, N-acetyl-piperidin-4-yl-methyl, 3H- benzooxazol-2-on-6-yl, or chroman-6-yl]

[0067] [in particular such -O-R02represents methoxy, ethoxy, isopropoxy, isobutoxy, sec-butoxy, phenoxy, 4-(2- hydroxy-ethyl)-phenoxy, 2-(2-hydroxy-ethyl)-phenoxy, benzyl-oxy, 2-(benzyl-oxy)-ethoxy, 2-methoxy-ethoxy, 3-hydroxy-propoxy, 2-hydroxy-2-methyl-propoxy, 2-hydroxy-ethoxy, 3-hydroxy-3-methyl-butoxy, 2,2-dimethyl- cyclopentyl-oxy, 3,3-difluoro-cyclopentyl-oxy, cyclohexyl-oxy, 4-hydroxy-cyclohexyl-oxy, 4-methyl-4-hydroxy- cyclohexyl-oxy,4-oxo-cyclohexyl-oxy, tetrahydrofuran-3-yl-oxy, tetrahydropyran-4-yl-oxy, tetrahydropyran-4- yl-methoxy, 3-methoxy-cyclopentyl-oxy, oxetan-3-yl-methoxy, 2-(pyridin-2-yl)-ethyl-oxy, (3-cyclopropyl-1 ,2,4- oxadiazol-5-yl)-methoxy, 2-(3,5-dimethyl-1,2,4-triazol-1-yl)-ethoxy, N-acetyl-piperidin-4-yl-methyl-oxy, 3H- benzooxazol-2-on-6-yl, or chroman-6-yl-oxy]

[0068] • -CºC-RT1, wherein

[0069] > RT1represents

[0070] ■Ci-4-alkyl (notably methyl, ethyl, isopropyl, or isobutyl), wherein said C -alkyl independently is mono-substituted with

[0071] ❖ hydroxy;

[0072] [in particular said Ci-4-alkyl represents hydroxy-methyl, 1 -hydroxy-ethyl, 2-hydroxy-ethyl, 1- hydroxy-2-methyl-propyl, 1 -hydroxy-1 -methyl-ethyl, or 1 -hydroxy-1 -trifluoromethyl-ethyl];

[0073] ❖ Ci-3-alkoxy (especially methoxy);

[0074] ❖ -S(=0)2-Rsot, wherein RS0Trepresents Ci_3-alkyl, Ci_3-alkyl-amino, or C3.5- cycloalkyl (especially such -S(=0)2-RS0Trepresents methyl-sulfonyl, methyl- amino-sulfonyl or cyclopropyl-sulfonyl);

[0075] ❖ -NRNT1RNT2wherein RNT1represents hydrogen and RNT2represents Ci.3-alkyl- carbonyl, Ci-3-alkoxy-Ci.3-alkyl-carbonyl, or C3-5-cycloal kyl-carbonyl (especially such -NRNT1RNT2represent acetyl-amino, isopropyl-carbonyl-amino, methoxy- methyl-carbonyl-amino, or cyclopropyl-carbonyl-amino);

[0076] ❖ C4-6-heterocyclyl containing one or two ring heteroatom(s) independently selected from nitrogen and oxygen (notably oxazolidinyl, imidazolidinyl, or pyrrolidinyl; especially oxazolidin-3-yl, imidazolidin-3-yl, or pyrrolidin-1-yl); wherein said C4-6- heterocyclyl is mono-substituted with oxo; or di-substituted with oxo and Ci.3-alkyl (especially methyl); (especially such C4-6-heterocyclyl represents oxazolidin-2-on- 3-yl, imidazolidin-2-on-3-yl, 1-methyl-imidazolidin-2-on-3-yl, or pyrrolidin-2-on-1- yl); or

[0077] ❖ N-(Ci-3-alkyl-carbonyl)-piperidinyl-Ci-3-al kyl (especially N-acetyl-piperidin-4-yl- methyl);

[0078] ■C3-6-cycloalkyl (especially cyclopropyl) which is mono-substituted (especially at the point of attachment of the C3-6-cycloalkyl to the rest of the molecule) with

[0079] ❖ hydroxy;

[0080] ❖ amino-sulfonyl which is optionally di-substituted with methyl;

[0081] ❖ phenyl which is mono-substituted with halogen (especially 4-fluoro-phenyl); ❖ pyridinyl (especially pyridine-2-yl);

[0082] ❖ pyrimidinyl which is mono-substituted with Ci_3-alkyl (especially 6-methyl-pyrimidin- 4-yi);

[0083] ❖ oxazolidinonyl (especially oxazolidin-2-on-3-yl);

[0084] [in particular such C3-6-cycloalkyl represents 1 -hydroxy-cyclopropyl, 1 -hydroxy-cyclobutyl, 1- hydroxy-cyclopenty, 1 -(amino-sulfonyl)-cyclopropyl, 1 -(dimethyl-amino-sulfonyl)- cyclopropyl, 1-(6-methyl-pyrimidin-4-yl)-cyclopropyl, 1-(pyridine-2-yl)-cyclopropyl, 1-(4- fluoro-phenyl)-cyclopropyl, 1-(pyridine-2-yl)-cyclopropyl, or 1-(oxazolidin-2-on-3-yl)- cyclopropyl];

[0085] ■C3-6-cycloalkyl (notably cyclopentyl or cyclohexyl) fused with a pyridine ring (notably at positions 2 and 3 of the pyridine ring), wherein said C3-6-cycloalkyl is mono-substituted with hydroxy (notably at position 1 of the C3-6-cycloalkyl ring); wherein optionally one ring carbon atom in said C3.6-cycloalkyl is replaced with one oxygen atom;

[0086] [in particular such C3.6-cycloalkyl represents 8-hydroxy-5,6,7,8-tetrahydroquinolin-8-yl, 7- hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl, or 4-hydroxy-3,4-dihydro-2H-pyrano[3,2- b]pyridin-4-yl);

[0087] ■C4-6-heterocyclyl containing one ring heteroatom independently selected from nitrogen and oxygen (notably azetidinyl, pyrrolidinyl, piperidinyl, tetrahydropyranyl; especially azetidin-3- yl, piperidin-4-yl, pyrrolidin-3-yl, pyrrolidin-2-yl, pyrrolidine-1-yl, or tetrahydropyran-4-yl); wherein said C4-6-heterocyclyl is mono-, di-, or tri-substituted (especially mono- or di- substituted), wherein the substituent(s) is(are) independently selected from Ci_3-alkyl (especially methyl), hydroxy, oxo, Ci.3-alkyl-carbonyl (especially acetyl), Ci_3-alkoxy- carbonyl (especially tert-butoxy-carbonyl), Ci.3-alkyl-sulfonyl (especially methyl-sulfonyl), and Ci-3-alkyl-amino-sulfonyl (especially methyl-amino-sulfonyl);

[0088] [in particular such C4-6-heterocyclyl represents N-(isopropyl-carbonyl)-3-hydroxy-azetidin-3- yl, N-(tert-butoxy-carbonyl)-3-hydroxy-azetidin-3-yl, N-methyl-3-hydroxy-pyrrolidin-2-one-3- yl, N-acetyl-2-methyl-pyrrolidin-2-yl, 3-hydroxy-N-(tert-butoxy-carbonyl)-pyrrolidin-3-yl, 2- oxo-pyrrolidine-1-yl, N-acetyl-piperidin-4-yl, N-acetyl-4-methyl-piperidin-4-yl, N-(methyl- amino-sulfonyl)-4-methyl-piperidin-4-yl, N-acety l-4-hydroxy-pi peri di n-4-yl , N-(methyl- sulfonyl)-piperidin-4-yl, N-(tert-butoxy-carbonyl)-piperidin-4-yl, 3-hydroxy-2-oxo-1-methyl- pyrrolidin-2-yl, or 4-hydroxy-tetrahydropyran-4-yl);

[0089] ■pyrazolyl (notably 1 H-pyrazol-4-yl) which is N-substituted with methyl;■indolyl (especially indol-2-yl);

[0090] ■3-hydroxy-1 -methyl-1, 3-d i hy d ro-i ndol-2-on-3-y I ; or

[0091] ■4-hydroxy-3,4-dihydro-2H-pyrano[3,2-b] pyridin-4-yl;

[0092] [in particular such -CºC-RT1represents 3-hydroxy-3-trifluoromethyl-but-1-yn-1-yl, 3-hydroxy-prop- 1 -y n-1 -yl , 4- hydroxy-but-1 -yn-1 -yl, 3-hydroxy-but-1-yn-1-yl, 3-hydroxy-3-methyl-but-1-yn-1-yl, 3-methyl-3-(pyrrolidin-2-on- 1-yl)-but-1-yn-1-yl, 3-methyl-3-(cyclopropyl-sulfonyl)-but-1 -yn-1 -yl, 3-methyl-3-(acetyl-amino)-but-1 -yn-1 -yl, 3- methyl-3-(oxazolidin-2-on-3-yl)-but-1 -yn-1 -yl, 3-methyl-3-(imidazolidin-2-on-3-yl)-but-1 -yn-1 -yl, 3-methyl-3-(1- methyl-imidazolidin-2-on-3-yl)-but-1-yn-1-yl, 3-methyl-3-(2-oxo-pyrrolidine-1 -yl)-but-1 -yn-1 -yl, 3-methyl-3- (methyl-sulfonyl)-but-l -yn-1 -yl, 3-methyl-3-(cyclopropyl-carbonyl-amino)-but-1 -yn-1 -yl, 3-methyl-3-( isopropyl- carbonyl-amino)-but-1 -yn-1 -yl, 3-methyl-3-(methoxy-methyl-carbonyl-amino)-but-1-yn-1-yl, 3-hydroxy-4- methyl-pent-1 -yn-1 -yl, 3-methoxy-prop-1 -yn-1 -yl, 3-(N-acetyl-piperidin-4-yl)-prop-1-yn-1-yl, (1-hydroxy- cyclopropyl)-ethynyl, (l-hydroxy-cyclobutyl)-ethynyl, (l-hydroxy-cyclopentyl)-ethynyl, (8-hy d roxy-5, 6,7,8- tetrahydroquinolin-8-yl)-ethynyl, (7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl)-ethynyl, (1-methyl- pyrazol-4-yl)-ethynyl, (tetrahydropyran-4-yl)-ethynyl, (4-hydroxy-tetrahydropyran-4-yl)-ethynyl, indol-2-yl- ethynyl, (1-(isopropyl-carbonyl)-3-hydroxy-azetidin-3-yl)-ethynyl, (1-(tert-butoxy-carbonyl)-3-hydroxy-azetidin- 3-yl)-ethynyl, (1-(6-methyl-pyrimidin-4-yl)-cyclopropyl)-ethynyl, (N-acetyl-4-methyl-piperidin-4-yl)-ethynyl, (N- acetyl-4-hydroxy-piperidin-4-yl)-ethynyl, (1-(4-fluoro-phenyl)-cyclopropyl)-ethynyl, (N-acetyl-piperidin-4-yl)- ethynyl, (N-(methyl-sulfonyl)-piperidin-4-yl)-ethynyl, (1-(dimethyl-amino-sulfonyl)-cyclopropyl)-ethynyl, (1- (amino-sulfonyl)-cyclopropyl)-ethynyl, (N-(methyl-amino-sulfonyl)-4-methyl-piperidin-4-yl)-ethynyl, (1- (pyridine-2-yl)-cyclopropyl)-ethynyl, (3-hydroxy-N-(tert-butoxy-carbonyl)-pyrrolidin-3-yl)-ethynyl, (1- (oxazolidin-2-on-3-yl)-cyclopropyl)-ethynyl, (3-hydroxy-1 -methyl-1, 3-dihydro-indol-2-on-3-yl)-ethynyl, (4- hydroxy-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-ethynyl, (N-(tert-butoxy-carbonyl)-piperidin-4-yl)-ethynyl, (N-acetyl-2-methyl-pyrrolidin-2-yl)-ethynyl, or (3-hydroxy-2-oxo-1-methyl-pyrrolidin-3-yl)-ethynyl]

[0093] • -CºC-C(OH)(RT2)(RT3), wherein

[0094] > RT2represents hydrogen or Ci_3-alkyl (notably methyl or ethyl; especially methyl);

[0095] > RT3represents

[0096] ■phenyl which is unsubstituted or mono-substituted, wherein the substituent, if any, is selected from Ci_3-alkoxy (notably methoxy) or halogen (notably fluorine);

[0097] [in particular such phenyl which is unsubstituted or mono-substituted is 2-fluoro-phenyl, 4- methoxy-phenyl, or 2-methoxy-phenyl]

[0098] ■5- to 6-membered heteroaryl containing one or two ring heteroatom(s) being independently selected from nitrogen, oxygen, or sulfur (notably thiophenyl, thiazolyl, pyrrolyl, pyrazolyl, isoxazolyl, pyridinyl, pyrazinyl, or pyrimidinyl; especially thiophen-2-yl, thiazol-4-yl, thiazol- 5-yl, pyrrol-2-yl, pyrazol-3-yl, pyrazol-4-yl, isoxazol-5-yl, pyridin-2-yl, pyrimidin-2-yl, pyrazin- 2-yl, or pyrimidin-4-yl), wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono- or di- substituted, and wherein the substituent(s), if any, is(are) independently selected from Ci-3-alkyl (especially methyl), Ci-3-cycloalkyl (especially cyclopropyl), Ci-3-fluoroalkyl (notably Crfluoroalkyl; especially difluoromethyl or trifluoromethyl), and Ci-3-alkoxy (especially methoxy);

[0099] [in particular such 5- to 6-membered heteroaryl is 5-methyl-thiophen-2-yl, 2-methyl-thiazol- 5-yl, 1 -methyl-1 H-pyrrol-2-yl, 1 -cyclopropyl- 1 H-pyrazol-3-yl, 1 -methyl-1 H-pyrazol-3-yl, 1,3- dimethyl-pyrazol-4-yl, 1,5-dimethyl-1 H-pyrazol-3-yl, 2-methyl-thiazol-4-yl, 3-methyl- isoxazol-5-yl, 1 -methyl-1 H-imidazol-2-yl, pyridin-2-yl, 6-methoxy-pyridin-2-yl, 6-methyl- pyridin-2-yl, pyrimidin-2-yl, 2-methoxy-pyrimidin-4-yl, 6-methoxy-py rimi di n-4-yl , pyrimidin-4- yl, 2-methyl-pyrimidin-4-yl, 6-methyl-pyrimidin-4-yl, 2,6-dimethyl-pyrimidin-4-yl, 2,6- dimethoxy-pyrimidin-4-yl, 2-methyl-6-methoxy-pyrimidin-4-yl, 2-methoxy-6-methyl- pyrimidin-4-yl, 5-methyl-pyrazin-2-yl, 1 -cyclopropyl- 1 H-pyrazol-3-yl, 6-cyclopropyl- pyrimidin-4-yl, 6-difluoromethyl-pyrimidin-4-yl, 2-trifluoromethyl-pyrimidin-4-yl, 6- trifluoromethyl-pyrimidin-4-yl, or 1 ,5-dimethyl-1 H-pyrazol-3-yl]

[0100] ■C4-7-heterocyclyl containing one ring heteroatom selected from nitrogen and oxygen; wherein said C4-7-heterocyclyl is unsubstituted, mono-, or di-substituted, wherein the substituent(s), if any, is(are) independently selected from Ci_3-alkyl (especially methyl) or Ci_3-alkyl-carbonyl (especially acetyl); or

[0101] [in particular such C4-7-heterocyclyl represents N-acetyl-piperidin-4-yl, N-acetyl-4-methyl- piperidin-4-yl, or tetrahydropyran-4-yl]

[0102] ■indazolyl (especially indazol-3-yl);

[0103] [in particular such -CºC-C(OH)(RT2)(RT3) represents 3-hydroxy-3-(5-methyl-thiophen-2-yl)-but-1 -yn-1 -yl, 3- hydroxy-3-(2-methyl-thiazol-5-yl)-but-1-yn-1-yl, 3-hydroxy-3-(1 -methyl-1 H-pyrrol-2-yl)-but-1 -yn-1 -yl, 3-hydroxy-3- (3-methyl-isoxazol-5-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(1-methyl-1H-pyrrol-2-yl)-but-1-yn-1-yl, 3-hydroxy-3-(1-methyl- 1H-imidazol-2-yl)-but-1-yn-1-yl, 3-hydroxy-3-(5-methyl-pyrazin-2-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(tetrahydropyran- 4-yl)-prop-1-yn-1-yl, 3-hydroxy-3-(N-acetyl-piperidin-4-yl)-prop-1-yn-1-yl, 3-hydroxy-3-(N-acetyl-4-methyl- piperidin-4-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-phenyl-prop-1 -yn-1 -yl, 3-hydroxy-3-(2-methyl-thiazol-4-yl)-prop-1 -yn-1 - yl, 3-hydroxy-3-(1,3-dimethyl-pyrazol-4-yl)-prop-1-yn-1-yl, 3-hydroxy-3-phenyl-but-1 -yn-1 -yl, 3-hydroxy-3-(1- methyl-1 H-pyrazol-3-yl)-but-1-yn-1-yl, 3-hydroxy-3-(1-cyclopropyl-1H-pyrazol-3-yl)-but-1-yn-1-yl, 3-hydroxy-3- (1,5-dimethyl-1H-pyrazol-3-yl)-but-1-yn-1-yl, 3-hydroxy-3-(1 -methyl-pyrazol-3-yl)-but-1 -yn-1 -yl, 3-hydroxy-3- (pyrimidin-2-yl)-but-1-yn-1-yl, 3-hydroxy-3-(1 -methyl-pyrazol-3-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(3-fluoro-phenyl)-but- 1-yn-1-yl, 3-hydroxy-3-(6-methyl-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(2-methoxy-pyrimidin-4-yl)-but-1-yn-1- yl, 3-hydroxy-3-(2-methoxy-6-methyl-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(6-methoxy-pyrimidin-4-yl)-but-1- yn-1-yl, 3-hydroxy-3-(2,6-dimethoxy-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(2-methyl-pyrimidin-4-yl)-but-1-yn- 1-yl, 3-hy d roxy-3-(6-methoxy-2-methy l-py ri midi n-4-y l)-but- 1 -y n- 1 -y 1 , 3-hydroxy-3-(pyridin-2-yl)-pent-1-yn-1-yl, 3- hydroxy-3-(6-methoxy-pyridin-2-yl)-but-1-yn-1-yl, 3-hydroxy-3-(6-methyl-pyridin-2-yl)-but-1-yn-1-yl, 3-hydroxy-3- (6-methyl-pyridin-2-yl)-pent-1 -yn-1 -yl, 3-hydroxy-3-(2,6-dimethyl-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(6- methoxy-pyridin-2-yl)-pent-1-yn-1-yl, 3-hydroxy-3-(1H-indazol-3-yl)-but-1-yn-1-yl, 3-hydroxy-3-(6-cyclopropyl- pyrimidin-4-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(6-difluoromethyl-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(2- trifluoromethyl-pyrimidin-4-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(6-trifluoromethyl-pyrimidin-4-yl)-but-1-yn-1-yl, 3- hydroxy-3-(indazol-3-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(4-methoxy-phenyl)-but-1-yn-1-yl, or 3-hydroxy-3-(2-methoxy- phenyl)-but-1 -yn-1 -yl]

[0104] • -NRN3RN4wherein

[0105] > RN3represents Ci_3-alkyl (especially methyl); and

[0106] RN4represents hydroxy-Ci-3-alkyl (especially 2-hydroxy-ethyl) or 2-(benzyl-oxy)-Ci-3-alkyl (especially 2-(benzyl-oxy)-ethyl); or

[0107] > RN3and RN4form, together with the nitrogen to which they are attached, a heterocyclic ring of 4 to 6 members (notably 5 to 6 members), wherein the members needed to complete said heterocyclic ring are each independently selected from -CH2-, -0-, -(C=0)-, -CHRX- and -C(RY)2-; wherein said heterocyclic ring does not contain more than one member independently selected from the group consisting of -O- and -(C=0)-; wherein said heterocyclic ring does not contain more than two members selected from the group consisting of -CHRX-; and wherein said heterocyclic ring does not contain more than two members selected from the group consisting of -C(RY)2-; wherein Rxindependently represents fluorine, methyl, isopropyl, isobutyl, tert-butyl, hydroxy, trifluoromethyl, hydroxy-methyl, 1 -hydroxy-ethyl, 1 -hydroxy- 1 -methyl -ethyl , cyclopropyl, 2-methoxy-ethyl, 2-methyl- thiazol-5-yl, 4-methyl-thiazol-2-yl, phenyl, benzyl, tetrahydropyran-4-yl, N-acetyl-piperidin-4-yl, 1,2,4- oxadiazolyl, 3-methyl-1,2,4-oxadiazol-5-yl, 2-methyl-2H-[1,2,3]triazol-4-yl, 1 -methyl-1 H-pyrazol-4-yl, 1 -difluoromethyl-1 H-pyrazol-4-yl, 1 ,3-dimethyl-1 H-pyrazol-4-yl, pyridin-2-yl, 6-methyl-pyridin-3-yl, 6- isopropyl-pyridin-2-yl, 6-trifluoromethyl-pyridin-3-yl, 2-isopropyl-pyrimidin-4-yl, or 1-methoxy-methyl; and wherein RYindependently represents fluorine, hydroxy, cyclopropyl, methyl, hydroxy-methyl, or trifluoromethyl [notably such -NRN3RN4is pyrrolidinyl; 2-pyrrolidonyl; oxazolidinonyl (especially 1,3- oxazolidin-2-on-3-yl); piperidinyl; or morpholinyl, optionally independently substituted with one or two substituents independently selected from a group consisting of Rxand R11];

[0108] [in particular such -NRN3RN4represents pyrrolidin-1-yl, 3-fluoro-pyrrolidin-l-yl, 3,3-difluoro-pyrrolidin-1-yl, 3,4- difluoro-pyrrolidin-1-yl, 3-isopropyl-pyrrolidin-1-yl, 3,3-dimethyl-pyrrolidin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 2- methyl-pyrrolidin-1-yl, 3-hydroxy-3-methyl-pyrrolidin-1-yl, 3-(hydroxy-methyl)-pyrrolidin-1-yl, 2-(hydroxy- methyl)-pyrrolidin-1-yl, 3-(1-hydroxy-ethyl)-pyrrolidin-1-yl, 3-hydroxy-3-cyclopropyl-pyrrolidin-1-yl, 3-hydroxy- 3-trifluoromethyl-pyrrolidin-1-yl, 3-trifluoromethyl-pyrrolidin-1-yl, 3-(1-hydroxy-1-methyl-ethyl)-pyrrolidin-1-yl,

[0109] 3-(1-hydroxy-ethyl)-pyrrolidin-1-yl, 3-(hydroxy-methyl)-3-methyl-pyrrolidin-1-yl, 1,3-oxazolidin-2-on-3-yl, 5- (tert-butyl)-1,3-oxazolidin-2-on-3-yl, 5-phenyl-1,3-oxazolidin-2-on-3-yl, 5-benzyl-1,3-oxazolidin-2-on-3-yl, 5- isopropyl-1 ,3-oxazolidin-2-on-3-yl, 5-(tetrahydropyran-4-yl)-1,3-oxazolidin-2-on-3-yl, 5,5-dimethyl-1,3- oxazolid i n-2-on-3-yl , morpholin-4-yl, piperidin-1-yl, 4-hydroxy-piperidin-1-yl, 3-hydroxy-piperidin-1-yl, 3- (tetrahydropyran-4-yl)-pyrrolid-2-on-1-yl, N-methyl-N-(2-(benzyl-oxy)-ethyl)-amino, N-methyl-N-(2-hydroxy- ethyl)-amino, pyrrolidin-2-on-1-yl, 4-phenyl-pyrrolidin-2-on-1-yl, 4-(N-acetyl-piperidin-4-yl)-pyrrolidin-2-on-1-yl,

[0110] 4-(pyridin-2-yl)-pyrrolidin-2-on-1-yl, 4-(6-methyl-pyridin-3-yl)-pyrrolidin-2-on-1-yl, 4-(2-isopropyl-pyrimidin-4- yl)-pyrrolidin-2-on-1-yl, 4-(6-isopropyl-pyridin-2-yl)-pyrrolidin-2-on-1-yl, 4-(6-trifluoromethyl-pyridin-3-yl)- pyrrolidin-2-on-1-yl, 4-methyl-pyrrolidin-2-on-1-yl, 4-isopropyl-pyrrolidin-2-on-1-yl, 3-isopropyl-pyrrolidin-2-on- 1-yl, 3,3-dimethyl-pyrrolidin-2-on-1-yl, 4,4-dimethyl-pyrrolidin-2-on-1-yl, 3-(piperidin-4-yl)-pyrrolidin-2-on-1-yl, 4-(1 -methyl-1 H-pyrazol-4-yl)-pyrrolidin-2-on-1-yl, 4-(1-difluoromethyl-1H-pyrazol-4-yl)-pyrrolidin-2-on-1-yl, 4- (1,3-dimethyl-1H-pyrazol-4-yl)-pyrrolidin-2-on-1-yl, 4-(6-isopropyl-pyridin-2-yl)-pyrrolidin-2-on-1-yl, 4-isobutyl- pyrrolidin-2-on-1-yl, 4-cyclopropyl-pyrrolidin-2-on-1-yl, 4-trifluoromethyl-pyrrolidin-2-on-1-yl, 3-(2-methoxy- ethyl)-pyrrolidin-2-on-1-yl, 4-(2-methoxy-ethyl)-pyrrolidin-2-on-1-yl, 2,2,6,6-tetrafluoro-morpholin-4-yl, 2,6- dimethyl-morpholin-4-yl, 2-(methoxy-methyl)-morpholin-4-yl, 3-(3-methy I- 1 , 2, 4-oxad i azol-5-y I )-pyrrol idin- 1 -y I, 4-(2-methyl-thiazol-5-yl)-pyrrolidin-2-on-1-yl, 4-(2-methyl-2H-[1,2,3]triazol-4-yl)-pyrrolidin-2-on-1-yl, 3-(4- methyl-thiazol-2-yl)-pyrrolidin-1-yl, or 3-(phenyl)-pyrrolidin-1-yl]

[0111] • -(C=0)-N(RN5)(RN6), wherein

[0112] > RN5represents hydrogen; and

[0113] RN6represents C3-6-cycloalkyl (especially cyclopentyl) or tetrahydropyranyl (especially tetrahydropyran-4-yl); or

[0114] > RN5and RN6form, together with the nitrogen to which they are attached, pyrrolidinyl;

[0115] [in particular such -(C=0)-N(RN5)(RN6) represents N-cyclopentyl-amino-carbonyl, N-(tetrahydropyran- 4-yl)-amino-carbonyl, or pyrrolidinyl-carbonyl] > piperidin-4-yl or pyrrolidin-3-yl which are mono-substituted at the nitrogen ring atom, wherein the substituent is independently selected from C -alkoxy-carbonyl (especially tert-butoxy-carbonyl), pyridinyl (especially pyridin-2-yl), phenyl and (4-methylphenyl)-sulfonyl;

[0116] [in particular such piperidin-4-yl or pyrrolidin-3-yl are N-(tert-butoxy-carbonyl)-piperidin-4-yl, N-(tert-butoxy- carbonyl)-pyrrolidin-3-yl, N-(pyridin-2-yl)-piperidin-4-yl, N-(phenyl)-piperidin-4-yl, or N-((4-methylphenyl)- sulfonyl)-piperidin-4-yl]

[0117] > 5- or 6-membered heteroaryl containing from one to three (notably two or three; especially three) ring heteroatom(s) independently selected from nitrogen, oxygen and sulfur (notably pyrazolyl, triazolyl, oxazolyl, thiazolyl, oxadiazolyl, pyrimidinyl, or pyridinyl; especially pyrazol-1-yl, 1 H-1 ,2,3-triazol-1-yl, oxazol-2-yl, thiazol- 2-yl, 1,2,4-oxadiazol-5-yl, 1,2,4-oxadiazol-3-yl, pyrimidin-2-yl, or pyridin-2-yl); wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono-, di-, or tri-substituted (notably mono-substituted; especially mono-substituted in position 3 with respect to the point of attachment of said 5- or 6-membered heteroaryl to A), wherein the substituent(s), if any, is(are) independently selected from

[0118] > Ci-4-alkyl (notably methyl, ethyl, propyl, isopropyl, or tert-butyl) which is

[0119] ■unsubstituted; or

[0120] ■mono-substituted with

[0121] ❖ hydroxy;

[0122] ❖ Ci-4-alkoxy (especially methoxy and tert-butoxy); or

[0123] ❖ -N(RN7)(RN8), wherein RN7represents hydrogen or Ci_3-alkyl (especially methyl); and RN8independently represent C3-5-cycloalkyl-carbonyl (especially cyclopropyl- carbonyl), Ci-3-alkyl (especially methyl), Ci_3-alkyl-carbonyl including deuterated Ci-3-alkyl-carbonyl (especially acetyl, ethyl-carbonyl, isopropyl-carbonyl, or acetyl- 2,2,2-d3), Ci-3-alkoxy-Ci-3-alkyl-carbonyl (especially methoxy-methyl-carbonyl), tetrahydropyranyl-carbonyl (especially tetrahydropyran-4-yl-carbonyl), or hydroxy- Ci-3-alkyl-carbonyl (especially hydroxy-methyl-carbonyl);

[0124] ■di-substituted, wherein one substituent is hydroxy, and the other substituent is trifluoromethyl; or both substituents are hydroxy; or

[0125] ■di- or tri-substituted, wherein two substituents are fluorine and, if present, a further substituent is hydroxy (wherein especially the hydroxy group is separated by at least two carbon atoms from any of said fluorine substituents);

[0126] [in particular such C -alkyl represents methyl, isopropyl, hydroxy-methyl, 1-hydroxy-1-methyl-ethyl, 2-hydroxy-2-methyl-propyl, 2-hydroxy-1 , 1 -dimethyl-ethyl, methoxy-methyl, 2-methoxy-ethyl, 1- methoxy-1 -methyl-ethyl, 2-methoxy-2-methyl-propyl, 2-methoxy-1, 1-dimethyl-ethyl, tert-butoxy- methyl; 1,2-dihydroxy-ethyl, N-acetyl-2-amino-ethyl, N-(acetyl-2,2,2-d3)-2-amino-ethyl, 2- (methylcarboxamido)-2-methyl-propyl, 2-(ethylcarboxamido)-2-methyl-propyl, 2-(cyclopropyl- carboxamido)-2-methyl-propyl, 2-(tetrahydropyran-4-yl-carboxamido)-2-methyl-propyl, 2-(methoxy- methyl-carboxamido)-2-methyl-propyl, 2-(ethyl-carboxamido)-2-methyl-propyl, 2-(isopropyl- carboxamido)-2-methyl-propyl, 2-(methyl-d3-carboxamido)-2-methyl-propyl, N-methyl-N-(hydroxy- methyl-carbonyl)-2-amino-ethyl, N-methyl-N-acetyl-2-amino-ethyl, 2, 2, 2-trifluoro-1 -hydroxy-1 - methyl-ethyl, 1 , 1 -difluoro-2-hydroxy-ethyl, 1,1-difluoro-ethyl, or N-methyl-N-(acetyl-2,2,2-d3)-2- amino-ethyl; in particular such C -alkyl group is 1 -hydroxy-1 -methyl-ethyl, 2-hydroxy-2-methyl- propyl, or 2-hydroxy-1 , 1 -dimethyl-ethyl]

[0127] > -L3-CY3, wherein

[0128] ■-L3- independently represents a bond (i.e. the CY3is directly attached to the rest of the molecule), -CH2-, -CH2-CH2-, -C(CH3)2-, -CH(OH)-, or -0-CH2-, wherein when -L3- is -0- CH2-, said CY3is attached to the oxygen atom of said -0-CH2-; and

[0129] ■CY3independently represents C3-6-cycloalkyl or C4-6-heterocyclyl, said C4-6-heterocyclyl containing one or two ring heteroatoms independently selected from nitrogen and oxygen (especially CY3represents cyclopropyl, cyclobutyl, oxetanyl, azetidinyl, pyrrolidinyl, tetrahydropyranyl, tetrahydrofuranyl, morpholinyl, imidazolidinyl, piperidinyl, or piperazinyl); wherein said CY3independently is unsubstituted, mono-, di-, or tri-substituted, wherein the substituents is selected from

[0130] > halogen (especially fluorine);

[0131] > oxo;

[0132] > hydroxy;

[0133] > Ci-3-alkyl which is optionally mono-substituted with Ci-3-alkoxy (especially such Ci_ 3-alkyl represents methyl, ethyl, isopropyl, or methoxy-methyl);

[0134] > Ci-3-alkoxy (especially methoxy);

[0135] > -(C=0)-Rco, wherein Rcorepresents o Ci-3-alkyl which is optionally mono-substituted with hydroxy or Ci-3-alkoxy (especially methyl, ethyl, n-propyl, isopropyl, tert-butyl, hydroxy-methyl, methoxy-methyl, benzyl-oxy, or 2-methoxy-ethyl); o Ci-3-fluoroalkyl (especially 2,2,2-trifluoro-ethyl); o Ci-3-alkoxy, wherein said Ci-3-alkoxy is optionally mono-substituted with Ci-3-alkoxy (especially methoxy, ethoxy, or 2-methoxy-ethoxy); o C3-6-cycloalkyl-(CH2)n-, wherein optionally one or two carbon ring atom(s) is / are replaced by one or two oxygen ring atom(s); wherein n represents the integer 0, 1, or 2 (especially such C3-5-cycloalkyl-(CH2)n- represents cyclopropyl, cyclopentyl, oxetan-3-yl, oxetan-3-yl-methyl, 1,4-dioxan-2-yl, or tetrahydropyran-4-yl); or o phenyl;

[0136] [especially such -(C=0)-Rcorepresents acetyl, ethyl-carbonyl, n-propyl-carbonyl, isopropyl-carbonyl, tert-butyl-carbonyl, hydroxymethyl-carbonyl, 2,2,2-trifluoro- ethyl-carbonyl, methoxy-methyl-carbonyl, 2-methoxy-ethyl-carbonyl, methoxy- carbonyl, ethoxy-carbonyl, 2-methoxy-ethoxy-carbonyl, cyclopropyl-carbonyl, cyclopentyl-carbonyl, oxetan-3-yl-carbonyl, oxetan-3-yl-methyl-carbonyl, phenyl- carbonyl, or tetrahydropyran-4-yl-carbonyl, methoxy-methyl-carbonyl, or 1,4- dioxan-2-yl-carbonyl]

[0137] > -N(RN9)(RN10), wherein RN9represents hydrogen or Ci_3-alkyl (especially methyl); and RN1° represents Ci_3-alkyl (especially methyl), C i -3-al kyl-carbony I (especially acetyl), Ci-3-alkyl-sulfonyl (especially methyl-sulfonyl), Ci-3-alkoxy-carbonyl (especially ethoxy-carbonyl), C i -3-al koxy-C 1-3-alky l-carbony I (especially methoxy- methyl-carbonyl), or tetrahydropyranyl-carbonyl (especially tetrahydropyran-4-yl- carbonyl);

[0138] > -S(=0)2-Rso, wherein Rsorepresents o Ci_3-alkyl which is optionally mono-substituted with hydroxy, Ci_3-alkoxy, or amino (especially such Ci_3-alkyl is methyl, n-propyl, isopropyl, 2- hydroxy-ethyl, 2-methoxy-ethyl, or methyl-amino); or o C3-5-cycloalkyl, wherein optionally one carbon ring atom is replaced by one oxygen ring atom (especially represents cyclopropyl, cyclopentyl, or tetrahydropyranyl);

[0139] [especially such -S(=0)2-Rsorepresents methyl-sulfonyl, n-propyl-sulfonyl, isopropyl-sulfonyl, 2-hydroxyethyl-sulfonyl, cyclopropyl-sulfonyl, cyclopentyl- sulfonyl, 2-methoxy-ethyl-sulfonyl, methyl-amino-sulfonyl, or tetrahydropyran-4-yl- sulfonyl]

[0140] > 5-membered heteroaryl containing one ring heteroatom selected from nitrogen, oxygen, and sulfur (notably oxygen); wherein said 5-membered heteroaryl is unsubstituted (notably furanyl; especially furan-2-yl); and > phenyl-(CH2)P-, wherein p represents the integer 0, 1 , or 2 (especially such phenyl- (CH2)p- represents phenyl or benzyl);

[0141] [in particular such -L3-CY3representsl -hydroxy-cyclopropyl, 1-(methyl-amino)-cyclopropyl, 1- (acetyl-amino)-cycloprop-l-yl-methyl, 1-(N-acetyl-N-methyl-amino)-cycloprop-1-yl-methyl, 1-(N- (methoxy-methyl-carbonyl)-amino)-cycloprop-1-yl-methyl, 1-(N-(ethoxy-carbonyl)-N-methyl-amino)- cycloprop-1-yl, 1-(N-methylacetamido)-cycloprop-1-yl (including 1-(N-methylacet-d3-amido)- cycloprop-1-yl), 1-(1-(methoxy-methyl)-cyclopropyl)-methyl, 1-(tetrahydropyran-4-yl-carbonyl- amino)-cyclopropyl-methyl, cyclobutyl-oxy-methyl, 1 -hydroxy-cyclobutyl, 3-hydroxy-cyclobutyl, 1- methoxy-cyclobutyl, 1-hydroxy-cyclopentyl, 3-hydroxy-3-methyl-cyclopentyl, 1 -hydroxy-cyclohexyl, 4-hydroxy-cyclohexyl, (1 -hydroxy-cyclohexyl)-methyl, (1 -hydroxy-cyclobutyl)-methyl, 1 -hydroxy-1 - cyclohexyl-methyl, 1-methoxy-cyclopentyl, oxetan-3-yl, tetrahydrofuran-2-yl-methyl, tetrahydrofuran-

[0142] 2-yl, tetrahydrofuran-3-yl, tetrahydropyran-3-yl, tetrahydropyran-4-yl, 4-hydroxy-tetrahydropyran-4-yl, 4-hydroxy-tetrahydropyran-4-yl-methyl, 4-methyl-tetrahydropyran-4-yl-methyl, 4-methyl- tetrahydropyran-4-yl, 2,6-dimethyl-tetrahydropyran-4-yl, 4-methoxy-tetrahydropyran-4-yl, 4-fluoro- tetrahydropyran-4-yl, tetrahydropyran-4-yl-methyl, 2-(tetrahydropyran-4-yl)-ethyl, 1 -(tetrahydropyran- 4-yl)-1 -methyl-ethyl, tetrahydropyran-4-yl-oxy-methyl, (4-methyl-tetrahydropyran-4-yl)-oxy-methyl, N- acetyl-3-fluoro-azetidin-3-yl (including N-acetyl-d3-3-fluoro-azetidin-3-yl), N-acetyl-3-methyl-azetidin-

[0143] 3-yl (including N-acetyl-d3-3-methyl-azetidin-3-yl), 2-oxo-azetidin-3-yl, 2-oxo-azetidin-4-yl, N-acetyl- azetidin-3-yl, 5-oxo-py rrol i d i n-2-yl , N-phenyl-5-oxo-pyrrolidin-2-yl, N-phenyl-5-oxo-pyrrolidin-3-yl, N- benzyl-5-oxo-pyrrolidin-3-yl, N-benzyl-2-oxo-pyrrolidin-3-yl, 5-oxo-py rrolid i n-3-y I , N-(furan-2-yl- methyl)-5-oxo-pyrrolidin-3-yl, 3-methyl-5-oxo-pyrrolidin-3-yl, 1-methyl-5-oxo-pyrrolidin-3-yl, 1- isopropyl-5-oxo-pyrrolidin-3-yl, 1,3-dimethyl-2-oxo-pyrrolidin-3-yl, 2-oxo-pyrrolidin-1 -yl-methyl, 2- oxo-pyrrolidin-1-yl-methyl, 1-ethyl-5-oxo-pyrrolidin-3-yl, 1-isobutyl-5-oxo-pyrrolidin-3-yl, N-acetyl- pyrrolidin-3-yl, N-acetyl-pyrrolidin-3-yl-methyl, 2, 5-dioxo-3,3-dimethyl-pyrrolidin-1 -yl-methyl, 2-oxo- imidazolidin-1-yl-methyl, 2-oxo-oxazolidin-3-yl-methyl, piperidin-4-yl, 1 -methyl-2, 6-dioxo-piperidin-4- yl, 4-methyl-piperidin-4-yl, 4-fluoro-piperidin-4-yl, 2-oxo-piperidin-4-yl, 6-oxo-piperidin-2-yl, 6-oxo- piperidin-3-yl, 1-methyl-6-oxo-piperidin-3-yl, 3-methyl-6-oxo-piperidin-3-yl, N-acetyl-piperidin-4-yl, N- acetyl-piperidin-4-yl-methyl, N-acetyl-2-methy I -pi perid i n-4-y I , N-acetyl-4-fluoro-piperidin-4-yl, N- acetyl-3-methyl-piperidin-4-yl, N-acetyl-4-methyl-piperidin-4-yl, N-acetyl-4-hydroxy-piperidin-4-yl, N- acetyl-4-methoxy-piperidin-4-yl, N-acetyl-piperidin-3-yl, N-acetyl-piperidin-3-yl-methyl, N-acetyl-3- methyl-piperidin-3-yl, N-acety l-3-hy d roxy-pi perid i n-3-y I , N-(isopropyl-carbonyl)-4-hydroxy-piperidin-

[0144] 4-yl, N-(tert-butyl-carbonyl)-piperidin-4-yl, N-(2-methoxy-ethoxy-carbonyl)-piperidin-4-yl, N- (hydroxymethyl-carbonyl)-piperidin-4-yl, N-(cyclopropyl-sulfonyl)-piperidin-4-yl, N-(methyl-sulfonyl)- piperidin-4-yl, N-(n-propyl-sulfonyl)-piperidin-4-yl, N-(isopropyl-sulfonyl)-piperidin-4-yl, N-(2-hydroxy- ethyl-sulfonyl)-piperidin-4-yl, N-(cyclopentyl-sulfonyl)-piperidin-4-yl, N-(methoxy-carbonyl)-piperidin- 4-yl, N-(cyclopropyl-carbonyl)-piperidin-4-yl, N-(cyclopentyl-carbonyl)-piperidin-4-yl, N-(methyl- amino-sulfonyl)-piperidin-4-yl, N-(2-methoxy-ethyl-sulfonyl)-piperidin-4-yl, N-(ethyl-carbonyl)-4- hydroxy-piperidin-4-yl, N-(methoxy-methyl-carbonyl)-piperidin-4-yl, N-(ethoxy-carbonyl)-piperidin-4- yl, N-acetyl-4-ethyl-piperidin-4-yl, N-(n-propyl-carbonyl)-piperidin-4-yl, N-(2-methoxy-ethyl-carbonyl)- piperidin-4-yl, N-(oxetan-3-yl-carbonyl)-piperidin-4-yl, N-(oxetan-3-yl-methyl-carbonyl)-piperidin-4-yl, N-(2,2,2-trifluoro-ethyl-carbonyl)-piperidin-4-yl, N-(tetrahydropyran-4-yl-carbonyl)-piperidin-4-yl, N- (phenyl-carbonyl)-piperidin-4-yl, N-(tetrahydropyran-4-yl-sulfonyl)-piperidin-4-yl, N-(benzyl-oxy- carbonyl)-piperidin-4-yl, N-(methoxy-methyl-carbonyl)-4-isopropyl-piperidin-4-yl, N-(1,4-dioxan-2-yl- carbonyl)-piperidin-4-yl, morpholin-4-yl, morpholin-4-yl-methyl, 1-methyl-1-(morpholin-4-yl)-ethyl, (2,6-dimethyl-morpholin-4-yl)-methyl, 2,4-dioxo-imidazolidin-1-yl-methyl, 2,5-dioxo-imidazolidin-1-yl- methyl, 2,5-dioxo-3-methyl-imidazolidin-1-yl-methyl, 2,4-dioxo-3-methyl-imidazolidin-1-yl-methyl, 2- oxo-3-methyl-imidazolidin-1-yl-methyl, 2-oxo-3-cyclopropyl-imidazolidin-1-yl-methyl, 2,5-dioxo- pyrrolidin-1-yl-methyl, N-acetyl-pyrrolidin-3-yl, or 4-acetyl-piperazin-1-yl];

[0145] > phenyl or 6-membered heteroaryl containing one or two ring nitrogen atom(s) (notably pyridinyl or pyrimidinyl; especially pyridin-3-yl or pyrimidin-4-yl); wherein said phenyl or 6-membered heteroaryl is independently unsubstituted or mono-substituted with Ci_3-alkyl (especially methyl) or Ci_3-alkoxy (especially methoxy);

[0146] [in particular such phenyl or 6-membered heteroaryl is 3-methoxy-phenyl, pyridin-3-yl, or 6-methyl- pirimidin-4-yl]

[0147] > py razoly I -C i_3-al ky I (especially 2-(pyrazol-1-yl)-ethyl);

[0148] > Ci-3-alkyl-sulfonyl-Ci-3-alkyl (especially methyl-sulfonyl-methyl);

[0149] > 3-hydroxymethyl-bicyclo[1.1.1]pent-1 -yl;

[0150] > 7-oxa-bicyclo[2.2.1]hept-2-yl; and

[0151] > 6-oxa-sp i ro [2.5] oct- 1 -y I ;

[0152] • 5-oxo-4-oxa-6-azaspiro[2.4]hept-6-yl, 5-aza-spiro[2.4]heptan-6-on-5yl, 2,2-dimethyl-6-oxo-5-oxa-7- azaspiro[3.4]oct-7-yl, 2-cyclopropyl-6-oxo-5-oxa-7-azaspiro[3.4]oct-7-yl, 2-oxo-1-oxa-3-azaspiro[4.4]non-3-yl, 8,8-difluoro-2-oxo-1-oxa-3-azaspiro[4.5]dec-3-yl, or 8-oxo-7-oxa-9-azadispiro[3.1.4.1]undec-9-yl;

[0153] • 7-aza-bicyclo[2.2.1]hept-7-yl, 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl, 6-oxa-3-aza-bicyclo[3.1.1]hept-3-yl, or 8- oxa-3-azabicyclo[3.2.1]oct-3-yl;

[0154] • 5-oxo-6-azaspiro[3.4]oct-6-yl, 3-oxo-2-azaspiro[4.4]non-2-yl, 1-oxa-3-aza-spiro[4.5]decan-2-on-3-yl, 1-oxo-2- azaspiro[4.5]dec-2-yl, 1-oxo-8-oxa-2-azaspiro[4.5]dec-2-yl, 3-oxo-8-oxa-2-azaspiro[4.5]dec-2-yl, or 4-oxo- hexahydro-5H-furo[2,3-c]pyrrol-5-yl; • 3-(7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl)propyl or 3-(8-hydroxy-5,6,7,8-tetrahydroquinolin-8- yl)propyl);

[0155] • 6-acetyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl;

[0156] • 6-acetyl-5,6,7,8-tetrahydro-1 ,6-naphthyridine-2-yl;

[0157] • 2-(6,7-dihydro-5H-[1]pyrindin-7-ol)-ethyl;

[0158] • 2-(8-hydroxy-5,6,7,8-tetrahydro-quinolin-8-yl)-ethyl;

[0159] • 7,8-dihydro-5H-[1 ,6]naphthyridin-6-yl;

[0160] • 2,3-dihydro-isoindol-1 -on-2-yl;

[0161] • 7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl; and

[0162] • 6-acetyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl;

[0163] B represents phenyl, which is unsubstituted, mono-, di- or tri-substituted, wherein a first substituent (especially in para- position with respect to the point of attachment of B to the rest of molecule), if present, is selected from

[0164] > halogen (especially bromine);

[0165] > Ci-5-alkyl (notably methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, 1 -ethyl-propyl, 2,2-dimethyl- propyl, 1,1 -dimethyl-propyl; especially methyl, ethyl, or isopropyl; in particular isopropyl);

[0166] > C2-4-alkenyl (especially prop-1 -en-2-yl);

[0167] > Ci-3-alkoxy (especially methoxy, ethoxy, or isopropoxy);

[0168] > Ci-3-alkoxy-Ci-4-alkyl (especially 3-methoxy-propyl);

[0169] > Ci-4-fluoroalkyl (especially trifluoromethyl, 1 -methyl- 1 -fl uoro-ethy 1 , 1,1-difluoro-ethyl, 2,2,2-trifluoro-ethyl, 1,1- dimethyl-1-trifluoromethyl-methyl, 1 , 1 ,2,2,2-pentafluoro-ethyl, or 1 ,2,2,2-tetrafluoro-1 -trifluoromethyl-ethyl);

[0170] > C3-5-cycloalkyl (especially cyclopropyl or cyclobutyl) which independently is unsubstituted or mono-substituted (notably at the point of attachment of said C3-5-cycloalkyl to the rest of the molecule) with Ci_3-alkyl (especially methyl) or Ci-3-fluoroalkyl (especially trifluoromethyl);

[0171] > -SFs;

[0172] > bicyclo[1.1.1]pent-1-yl;

[0173] > C3-5-cycloalkoxy (especially cyclopropoxy or cyclobutoxy); and

[0174] > C1-3-f I uo ro al koxy (especially trifluoromethoxy); and the remaining substituent / s of B, if present, independently is / are selected from halogen (notably fluorine or chlorine; especially said remaining substituent(s) are in eia-position with respect to the point of attachment of B to the rest of molecule) and Ci_3-alkyl (especially methyl); or B represents benzothiophenyl (notably 1 -benzothiopheny I; especially 1 -benzothiophen-5-yl) or naphthalenyl (especially naphthalen-2-yl); [in particular such B is phenyl, 4-bromo-phenyl, 4-methyl-phenyl, 4-ethyl-phenyl, 4-propyl-phenyl, 4-isopropyl-phenyl, 4-butyl-phenyl, 4-isobutyl-phenyl, 4-tert-butyl-phenyl, 4-(1-ethyl-propyl)-phenyl, 4-(1,1-dimethyl-propyl)-phenyl, 4-(2,2- dimethyl-propyl)-phenyl, 3-chloro-4-isopropyl-phenyl, 3-fl uoro-4-isopropy l-pheny 1 , 3,5-difluoro-4-isopropyl-phenyl, 3- methyl-4-isopropyl-phenyl, 4-(prop-1-en-2-yl)-phenyl, 4-cyclopropyl-phenyl, 4-methoxy-phenyl, 4-ethoxy-phenyl, 4- isopropoxy-phenyl, 4-trifluoromethyl-phenyl, 4-(1 -methyl-1 -fluoro-ethyl)-phenyl, 4-(1,1-difluoro-ethyl)-phenyl, 4-(2,2,2- trifluoro-ethyl)-phenyl, 4-(1,1 -dimethyl-1 -trifluoromethyl-methyl)-phenyl, 4-(1,1,2,2,2-pentafluoro-ethyl)-phenyl, 4- (1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl, 4-trifluoromethoxy-phenyl, 4-(1-methyl-cyclopropyl)-phenyl, 4- cyclobutyl-phenyl, 4-(pentafluoro-l6-sulfaneyl)-phenyl, 4-(bicyclo[1.1.1]pent-1-yl)-phenyl, 4-cyclopropoxy-phenyl, 4- cyclobutoxy-phenyl, 4-(trifluoromethoxy)-phenyl, 4-(3-methoxy-propyl)-phenyl, 4-(1 -trifluoromethyl-cyclopropyl)-phenyl, naphthalen-2-yl, or 1 -benzothiophen-5-yl]

[0175] R1represents Ci_3-alkyl (especially methyl or ethyl), cyano, or halogen (especially fluorine);

[0176] R2represents Ci_4-alkyl (especially methyl, ethyl, n-propyl, isopropyl, tert-butyl or isobutyl), C3.5-cycloalkyl (especially cyclopropyl or cyclobutyl), C3-5-cycloalkyl-Ci-3-alkyl (especially cyclopropyl-methyl), hydroxy-Ci-3-alkyl (especially 2- hydroxy-ethyl), Ci-3-alkoxy-Ci-3-alkyl (especially 2-methoxy-ethyl), or Ci-3-fluoroalkyl (especially 2,2-difluoro-ethyl, 3,3,3-trifluoro-propyl, or 2-fluoroethyl).

[0177] Definitions provided herein are intended to apply uniformly to the compounds of Formula (I) as defined in any one of embodiments 1) to 53), and, mutatis mutandis, throughout the description and the claims unless an otherwise expressly set out definition provides a broader or narrower definition. It is well understood that a definition or preferred definition of a term defines and may replace the respective term independently of (and in combination with) any definition or preferred definition of any or all other terms as defined herein. If not explicitly defined otherwise in the respective embodiment or claim, groups defined herein are unsubstituted.

[0178] The term "halogen”, used alone or in combination, means fluorine, chlorine, bromine, or iodine; notably fluorine or chlorine; especially fluorine.

[0179] The term "cyano", used alone or in combination, refers to a group -CN.

[0180] The term "oxy", used alone or in combination, refers to a group -0-.

[0181] The term "oxo”, used alone or in combination, refers to the group =0.

[0182] The term "amino”, used alone or in combination, refers to the group -NFI2.

[0183] The term "amino-carbonyl”, used alone or in combination, refers to the group -C(=0)-NH2.

[0184] The term "amino-carbonyl-oxy”, used alone or in combination, refers to the group -0-C(=0)-NH2, wherein substitutions to the amino group may be further defined. For example, l\l-(Ci-3-alkyl)-amino-carbonyl-oxy- means that the amino group of said amino-carbonyl-oxy group is substituted with a Cu-alkyl group, said Cu-alkyl group being defined hereinbelow. An example of N-(Ci-3-alkyl)-amino-carbonyl-oxy- is N-(isopropyl)-amino-carbonyl-oxy.

[0185] The term "alkyl”, used alone or in combination, refers to a saturated straight or branched hydrocarbon chain group containing one to six carbon atoms. The term “Cx-y-al kyl” (x and y each being an integer), refers to an alkyl group as defined before, containing x to y carbon atoms. In case a Cx-y-alkyl group is used in combination with another substituent, the term means that said substituent is linked through a Cx-y-alkyl group to the rest of the molecule. For example, a Ci_ 6-alkyl group contains from one to six carbon atoms. Examples of Ci-6-alkyl groups are the Cu-alkyl groups methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, and isobutyl, as well as n-pentyl, and isopentyl. A preferred example of a Cu-alkyl as used for the substituent R1is methyl. A preferred example of a Cu-alkyl as used for the substituent R2is ethyl or methyl; most preferably methyl. A particularly preferred example of a Cu-alkyl as used for the substituent of B is isopropyl.

[0186] The term "amino-alkyl”, used alone or in combination, refers to an alkyl group as defined before, wherein one hydrogen atom has been replaced by an amino group. The term "amino-Cx-y-alkyl” (x and y each being an integer), used alone or in combination, refers to an amino-alkyl group as defined before wherein the alkyl group contains x to y carbon atoms. For example, amino-Cu-alkyl is an amino-alkyl group containing from one to four carbon atoms. Examples of such amino-Cu-alkyl groups are amino-methyl, 1 -amino-ethyl, 2-amino-ethyl and 2-amino-2, 2-dimethyl-ethyl.

[0187] The term “hydroxyalkyl”, used alone or in combination, refers to an alkyl group as defined before, wherein one hydrogen atom has been replaced by a hydroxy group. The term "hydroxy-Cx.y-alkyl” (x and y each being an integer), used alone or in combination, refers to a hydroxyalkyl group as defined before wherein the alkyl group contains x to y carbon atoms. For example, a hydroxy-Cu-alkyl group is a hydroxyalkyl group as defined before which contains from one to six carbon atoms.

[0188] The term "hydroxy-alkyl” refers to an alkyl group as defined herein, wherein one hydrogen atom is replaced by one hydroxy group.

[0189] The term “oxetanyl-alkyl”, used alone or in combination, refers to an alkyl group as defined before, wherein one hydrogen atom has been replaced by an oxetanyl group; especially such oxetanyl group is oxetan-3-yl. The term “oxetanyl-Cx-y-alkyl” (x and y each being an integer), used alone or in combination, refers to an oxetanyl-alkyl group as defined before, wherein the alkyl group contains x to y carbon atoms. For example, an oxetanyl-Ci-3-alkyl group is an oxetanyl-alkyl group as defined before which contains from one to three carbon atoms.

[0190] The term “pyridinyl-al kyl”, used alone or in combination, refers to an alkyl group as defined before, wherein one hydrogen atom has been replaced by a pyridinyl group; especially such pyridinyl group is pyridin-2-yl. The term “pyridinyl-Cx-y-alkyl” (x and y each being an integer), used alone or in combination, refers to a pyridinyl-alkyl group as defined before, wherein the alkyl group contains x to y carbon atoms. For example, a pyridinyl-Ci-3-alkyl group is a pyridinyl-alkyl group as defined before which contains from one to three carbon atoms.

[0191] The term “pyrazolyl-alkyl”, used alone or in combination, refers to an alkyl group as defined before, wherein one hydrogen atom has been replaced by a pyrazolyl group; especially such pyrazolyl group is pyrazol-1-yl. The term "pyrazolyl-Cx-y-alkyl” (x and y each being an integer), used alone or in combination, refers to a pyrazolyl-alkyl group as defined before, wherein the alkyl group contains x to y carbon atoms. For example, a py razoly l-C 1-3-al ky I group is a pyrazolyl-alkyl group as defined before which contains from one to three carbon atoms.

[0192] The term “benzyl-oxy-alkyl”, used alone or in combination, refers to an alkyl group as defined before, wherein one hydrogen atom has been replaced by the group C6H5-CH2-O-. The term "benzyl-oxy-Cx-y-alkyl” (x and y each being an integer), used alone or in combination, refers to a benzyl-oxy-alkyl group as defined before, wherein the alkyl group contains x to y carbon atoms. For example, a benzyl-oxy-Ci_3-alkyl group is benzyl-oxy-alkyl group as defined before which contains from one to three carbon atoms.

[0193] The term "alkyl-carbonyl”, used alone or in combination, refers to an alkyl group as defined before, wherein one hydrogen atom has been replaced by the group -C(=0)-. The term “Cx-y-alkyl-carbonyl” (x and y each being an integer), used alone or in combination, refers to an alkyl-carbonyl group as defined before, wherein the alkyl group contains x to y carbon atoms. For example, a Ci-3-alkyl-carbonyl group is an alkyl-carbonyl group as defined before which contains from one to three carbon atoms.

[0194] The term "amino-carbonyl-oxy”, used alone or in combination, refers to the group F N-C(=0)-0-, wherein substitutions to the amino group may be further defined.

[0195] The term “(hydroxy-alkyl)-carbonyl”, used alone or in combination, refers to a hydroxy-alkyl group as defined before, wherein one hydrogen atom of the alkyl has been replaced by the group -C(=0)-. The term "(hydroxy-Cx.y-alkyl)- carbonyl” (x and y each being an integer), used alone or in combination, refers to (hydroxy-alkyl)-carbonyl group as defined before, wherein the alkyl group contains x to y carbon atoms. For example, a (hydroxy-Ci-3-alkyl)-carbonyl group is an (hydroxy-alkyl)-carbonyl group as defined before which contains from one to three carbon atoms.

[0196] The term “alkyl-sulfonyl-alkyl”, used alone or in combination, refers to an alkyl group as defined before, wherein one hydrogen atom has been replaced by an alkyl-sulfonyl group, wherein the alkyl part of the said alkyl-sulfonyl is as defined before. The term “Cxi-yi-alkyl-sulfonyl-CX2-y2-alkyl” (x1, x2, y1 and y2 each being an integer), used alone or in combination, refers to an alkyl-sulfonyl-alkyl group as defined before, wherein the alkyl groups contain independently from one another x1 to y1 and x2 to y2 carbon atoms. For example, a Ci_3-al kyl-sulfonyl-Ci_3-alkyl is an alkyl-sulfonyl- alkyl group as defined before which contains in both alkyl pats independently from one to three carbon atoms.

[0197] The term "fluoroalkyl”, used alone or in combination, refers to an alkyl group as defined before in which one or more (and possibly all) hydrogen atoms have been replaced by fluorine. The term “Cx-y-fluoroalkyl” (x and y each being an integer) refers to a fluoroalkyl group as defined before containing x to y carbon atoms. For example, a Ci-3-fluoroalkyl group contains from one to three carbon atoms in which one to seven hydrogen atoms have been replaced with fluorine. Examples of Ci_3-fluoroalkyl groups are trifluoromethyl, 2-fluoroethyl, 2,2-difluoroethyl and 2,2,2-trifluoroethyl.

[0198] The term "alkenyl”, used alone or in combination, refers to a straight or branched hydrocarbon chain an alkyl group as defined before, wherein said chain comprises one double bond. The term “Cx-y-alkenyl” (x and y each being an integer), used alone or in combination, refers to an alkenyl group as defined before, containing from x to y carbon atoms. For example, the term C3-5-alkenyl, used alone or in combination, refers to an alkenyl group as defined before containing from 3 to 5 carbon atoms. Examples of C3-5-alkenyl groups are -CH=CH2, -CH=CH2-CH3, -CH2-CH=CH2, and - C(CH3)=CH2.

[0199] The term "alkylene”, used alone or in combination, refers to a saturated, branched or straight, bivalent aliphatic hydrocarbon group, regarded as derived from an alkane by removal of two hydrogen atoms. The term "Cx.y-alkylene” (x and y each being an integer), used alone or in combination, refers to an alkylene group as defined before containing x to y carbon atoms. For example, a Ci-2-alkylene is an alkylene group as defined above containing one or two carbon atoms. Examples of Ci-2-alkylene groups are -CH2-, -(CFh^- and -CH(CH3)-.

[0200] The term "hydroxy-alkylene”, used alone or in combination, refers to an alkylene group as defined before, wherein one hydrogen atom has been replaced with a hydroxy group. The term "hydroxy-Cx-y-alkylene” (x and y each being an integer), used alone or in combination, refers to a hydroxy-alkylene group as defined before containing x to y carbon atoms. For example, a hydroxy-Ci-2-alkylene is a hydroxy-alkylene group as defined above containing one or two carbon atoms. Examples of hydroxy-Ci_2-alkylene groups are -CH(OH)-, -CH(OH)-CH2-, and -C(OH)(CH3)-; preferably - CH(OH)-.

[0201] The term oxy-Ci_2-alkylene, used alone or in combination, refers to the group -0-Ci_2-alkyiene, wherein Ci_2-alkylene is defined above. Preferably, oxy-Ci-2-alkylene is the group -O-CH2-.

[0202] The term "alkoxy”, used alone or in combination, refers to an alkyl group as defined before, wherein one hydrogen atom has been replaced by -O-.The term "Cx.y-alkoxy” (x and y each being an integer), used alone or in combination, refers to an alkoxy group as defined before, wherein the alkoxy group contains x to y carbon atoms. For example, a C1-3- alkoxy group is an alkoxy group as defined before which contains from one to three carbon atoms. Examples of C1-3- alkoxy groups are methoxy, ethoxy, n-propoxy, or isopropoxy; notably methoxy.

[0203] The term “alkoxy-alkyl”, used alone or in combination, refers to an alkyl group as defined before, wherein one hydrogen atom has been replaced by an alkoxy group as defined before. The term “Cxi_yi-al koxy-C^-^-al ky I” (x1, x2, y1 and y2 each being an integer), used alone or in combination, refers to an alkoxy-alkyl group as defined before, wherein the two hydrocarbon parts of the group contain independently from one another x1 to y1 and x2 to y2 carbon atoms. For example, a Ci-3-alkoxy-Ci-3-alkyl is an alkoxy-alkyl group as defined before which contains in the two hydrocarbon parts of the group independently from one to three carbon atoms. Examples of C i -3-al koxy-C i -3-al ky I groups are methoxy- methyl or ethoxy-ethyl.

[0204] The term "fluoroalkoxy”, used alone or in combination, refers to an alkoxy group as defined before containing one to three carbon atoms in which one or more (and possibly all) hydrogen atoms have been replaced with fluorine. The term "Cx-y-fluoroalkoxy” (x and y each being an integer) refers to a fluoroalkoxy group as defined before containing x to y carbon atoms. For example, a C i -3-f I u o r o al k oxy group contains from one to three carbon atoms in which one to seven hydrogen atoms have been replaced by fluorine. Examples of C i -3-f I u oro al koxy groups include trifluoromethoxy, difluoromethoxy, 2-fluoroethoxy, 2,2-difluoroethoxy and 2,2,2-trifluoroethoxy.

[0205] The term “C -alkoxy-carbonyl" refers to an alkoxy group as defined before attached to a carbonyl group (i.e. Ci-4- alkoxy-C(=0)-).

[0206] The term "cycloalkyl", used alone or in combination, refers to a saturated monocyclic hydrocarbon ring containing three to seven carbon atoms (preferably three to six carbon atoms). The term "Cx.y-cycloalkyl" (x and y each being an integer), refers to a saturated monocyclic hydrocarbon ring containing x to y carbon atoms. For example, a C3-6-cycloalkyl group contains from three to six carbon atoms. Examples of C3-6-cycloalkyl groups are cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.

[0207] Likewise, the term "Cx-y-heterocyclyl” refers to a cycloalkyl group as define above containing x to y ring atoms, wherein in said group one or more ring carbon atoms are replaced by heteroatoms as explicitly defined.

[0208] The term "cycloalkenyl”, used alone or in combination, refers to an unsaturated monocyclic hydrocarbon ring containing one double carbon-carbon ring bond, said ring containing four to six carbon (preferably five) atoms. The term "Cx.y- cycloalkenyl " (x and y each being an integer), refers to a cycloalkenyl ring as defined before containing x to y carbon atoms. For example, a C4-6-cycloalkenyl group contains from four to six carbon atoms. Examples of C4-6-cycloalkenyl groups are cyclobutenyl, cyclopentenyl and cyclohexenyl; notably cyclopentenyl; especially cyclopent- 1 -en- 1 -y I .

[0209] The term "cycloalkoxy”, used alone or in combination, refers to an cycloalkyl group as defined before, wherein one hydrogen atom has been replaced by -O-.The term "Cx-y-cycloalkoxy” (x and y each being an integer), used alone or in combination, refers to a cycloalkoxy group as defined before, wherein the cycloalkoxy group contains x to y carbon atoms. For example, a C3-5-cycloalkoxy group is a cycloalkoxy group as defined before which contains from three to five carbon atoms. Examples of C3-5-cycloalkoxy groups are cyclopropoxy, cyclobutoxy, or cyclopentoxy.

[0210] The term "cycloalkyl-sulfonyl", used alone or in combination, refers to a cycloalkyl group as defined before, wherein one hydrogen atom is replaced by a sulfonyl group (i.e. -S(=0)2-). The term "Cx.y-cycloalkyl-sulfonyl" (x and y each being an integer), refers to a cycloalkyl group containing x to y carbon atoms. For example, a C3-5-cycloalkyl-sulfonyl group contains from three to six carbon atoms. Examples of C3-5-cycloalkyl-sulfonyl groups are cyclopropyl-sulfonyl, cyclobutyl-sulfonyl and cyclopentyl-sulfonyl. The term "cycloalkyl-alkyl", used alone or in combination, refers to an alkyl group as defined before, wherein one hydrogen atom has been replaced by a cycloalkyl group as defined before. The term " Cxi-yi-cycloalkyl-CX2-y2-alkyl" (x1, x2, y1 and y2 each being an integer), used alone or in combination, refers to an cycloalkyl-alkyl group as defined before, wherein the two hydrocarbon parts of the group contain independently from one another x1 to y1 and x2 to y2 carbon atoms. For example, C3-5-cycloalkyl-Ci-3-alkyl is a cycloalkyl-alkyl group as defined before which contains in the cycloalkyl part from three to five carbon atoms, and an alkyl part which contains from one to three carbon atoms. Examples of C3-5-cycloalkyl-Ci-3-alkyl groups are cyclopropyl-methyl or cyclopropyl-ethyl.

[0211] The term “C3-6-cycloal kyl fused with a pyridine ring”, used alone or in combination, refers to a C3-6-cycloalkyl group as defined before which is fused with a pyridine ring. Examples of C3-6-cycloalkyl fused with a pyridine ring are the following groups: preferably the last two groups from left to right. It is understood that when a substituent is referred to as "C3-6-cycloalkyl fused with a pyridine ring” the point of attachment of said substituent to the rest of the molecule is in the C3-6-cycloalkyl part of the substituent and not in the fused pyridine ring.

[0212] The term “ hy d roxy-azeti d i ny I” , used alone or in combination, refers to an azetidinyl group substituted with a hydroxy group. Preferably, the term hydroxy-azetidinyl refers to 3-hydroxy-azetidin-3-yl.

[0213] The term "heteroaryl", used alone or in combination, means a 5- to 10-membered monocyclic or bicyclic aromatic ring containing one to a maximum of four heteroatoms (notably containing one to a maximum of three heteroatoms), each independently selected from oxygen, nitrogen and sulfur. Examples of such heteroaryl groups are furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thiophenyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothiophenyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzoisothiazolyl, benzotriazolyl, benzoxadiazolyl, benzothiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrrolopyridinyl, pyrazolopyridinyl, pyrazolopyrimidinyl, pyrrolopyrazinyl, imidazopyridinyl, imidazopyridazinyl, and imidazothiazolyl. The above-mentioned heteroaryl / heteroarylene groups are unsubstituted or substituted as explicitly defined.

[0214] The term "5- to 6-membered heteroaryl", used alone or in combination, refers to a 5- to 6-membered monocyclic aromatic ring and containing one to a maximum of four ring heteroatoms (preferably one to a maximum of three ring heteroatoms), each independently selected from oxygen, nitrogen and sulfur. Examples of 5-membered groups are 5- membered heteroaryl groups such as furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thiophenyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl; notably pyrazolyl, triazolyl, oxazolyl, thiazolyl, oxadiazolyl; especially pyrazol-1-yl, 1,2,3-triazol-1-yl, oxazol-2-yl, thiazol-2-yl, 1,2,4-oxadiazol-5-yl or 1,2,4-oxadiazol-3-yl; most preferably 1,2,4-oxadiazol-5-yl or 1,2,4-oxadiazol-3-yl. Examples of 6-membered heteroaryl groups are groups such as pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl. The above-mentioned heteroaryl groups are unsubstituted or substituted as explicitly defined.

[0215] In the context of mono-substituted 5-membered heteroaryl groups, it is understood that a substitution in position 3 with respect to the point of attachment of a 5-membered heteroaryl to A means that the substituent in position 3 and the point of attachment to A are in a relative 1,3-arrangement. Preferred examples of such 5-membered heteroaryl groups which are mono-substituted in position 3 with respect to the point of attachment of said 5-membered heteroaryl to A are selected from a group consisting of wherein one asterisk (*) denotes the attachment point to the substituent and two asterisks (**) denote the attachment point to A. Especially preferred are the last two (from left to right) 5-membered heteroaryl groups.

[0216] Further embodiments of the invention are presented hereinafter:

[0217] 2) One embodiment relates to compounds according to embodiment 1), wherein A represents pyridinyl, pyrimidinyl, pyrazinyl, or pyridazinyl (notably pyridazinyl or pyridinyl; especially pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrimidin-5-yl, pyrazin-2-yl, or pyridazin-4-yl), wherein A is independently unsubstituted, mono-, di- or tri-substituted (notably mono- or di-substituted in meta- and / or para- position of A with respect to the point of attachment of A to the rest of the molecule; especially mono-substituted in eia-position of A with respect to the point of attachment of A to the rest of the molecule), wherein the substituent(s), if any, is(are) as defined in embodiment 1).

[0218] 3) Another embodiment relates to compounds according to embodiment 1), wherein A represents pyridin-3-yl, pyridin- 4-yl, or pyridazin-4-yl (in particular pyridin-3-yl or pyridazin-4-yl), wherein A is independently unsubstituted, mono-, di- or tri-substituted (notably mono- or di-substituted in meta- and / or para- position of A with respect to the point of attachment of A to the rest of the molecule; especially mono-substituted in meia-position of A with respect to the point of attachment of A to the rest of the molecule), wherein the substituent(s), if any, is(are) as defined in embodiment 1).

[0219] In a sub-embodiment, A is independently > unsubstituted; > mono-substituted (notably in eia-position of A with respect to the point of attachment of A to the rest of the molecule), wherein the substituent is as defined in embodiment 1); or

[0220] > di-substituted, wherein a first substituent is (notably in meia-position of A with respect to the point of attachment of A to the rest of the molecule) selected from the substituents defined in embodiment 1) (especially excluding halogen (especially fluorine) or cyano); and a second substituent is (notably in para- position of A with respect to the point of attachment of A to the rest of the molecule) selected from halogen (especially fluorine) and cyano.

[0221] 4) Another embodiment relates to compounds according to embodiment 1), wherein A represents pyridin-3-yl, pyridin- 4-yl, or pyridazin-4-yl (especially pyridin-3-yl or pyridazin-4-yl; in particular pyridin-3-yl), wherein A is mono-substituted (notably in meia-position of A with respect to the point of attachment of A to the rest of the molecule), wherein the substituent is as defined in embodiment 1).

[0222] 5) Another embodiment relates to compounds according to any one of embodiments 1) to 4), wherein said substituent of A / at least one of said substituents of A is

[0223] • -O-R02as defined in embodiment 1).

[0224] 6) Another embodiment relates to compounds according to embodiment 5), wherein said substituent of A / at least one of said substituents of A is

[0225] > -O-R02, wherein

[0226] > R02represents

[0227] ■Ci-4-alkyl (especially isopropyl, sec-butyl, or isobutyl);

[0228] ■C2-5-alkyl which is mono-substituted with hydroxy or Ci-3-alkoxy (especially methoxy);

[0229] [in particular such C2-5-alkyl represents 2-hydroxy-ethyl, 3-hydroxy-propyl, 2-hydroxy-2- methyl-propyl, 3-hydroxy-3-methyl-butyl, or 2-methoxy-ethyl]

[0230] ■-L2-CY2, wherein

[0231] ❖ -L2- independently represents a bond (i.e. the CY2is directly attached to the rest of the molecule); and

[0232] ❖ CY2independently represents o C3-6-cycloalkyl (especially oxetanyl, cyclopentyl or cyclohexyl), wherein optionally one carbon ring atom is replaced by one oxygen atom; wherein said C3-6-cycloalkyl is unsubstituted, mono-, or di-substituted, wherein the substituents are selected from Ci_3-alkyl (especially methyl), hydroxy, fluoro, oxo, Ci-3-alkyl-carbonyl (especially acetyl), and Ci.3-alkoxy (especially methoxy); o chromanyl (especially chroman-6-yl);

[0233] [in particular such -L^CY2represents 2-(benzyl-oxy)-ethyl, 2,2-dimethyl-cyclopentyl, 3,3- difluoro-cyclopentyl, 3-methoxy-cyclopentyl, cyclohexyl, 4-hydroxy-cyclohexyl, 4-methyl-4- hydroxy-cyclohexyl, 4-oxo-cyclohexyl, tetrahydrofuran-3-yl, tetrahydropyran-4-yl, tetrahydropyran-4-yl-methyl, or chroman-6-yl]

[0234] [in particular such -O-R02represents isopropoxy, isobutoxy, sec-butoxy, 2-(benzyl-oxy)-ethoxy, 2-methoxy- ethoxy, 3-hydroxy-propoxy, 2-hydroxy-2-methyl-propoxy, 2-hydroxy-ethoxy, 3-hydroxy-3-methyl-butoxy, 2,2- dimethyl-cyclopentyl-oxy, 3,3-difluoro-cyclopentyl-oxy, cyclohexyl-oxy, 4-hydroxy-cyclohexyl-oxy, 4-methyl-4- hydroxy-cyclohexyl-oxy,4-oxo-cyclohexyl-oxy, tetrahydrofuran-3-yl-oxy, tetrahydropyran-4-yl-oxy, tetrahydropyran-4-yl-methoxy, 3-methoxy-cyclopentyl-oxy, or chroman-6-yl-oxy]

[0235] 7) Another embodiment relates to compounds according to any one of embodiments 1) to 4), wherein said substituent of A / at least one of said substituents of A is

[0236] • C3-5-alkyl as defined in embodiment 1).

[0237] 8) Another embodiment relates to compounds according to embodiment 7), wherein said substituent of A / at least one of said substituents of A is

[0238] • C3-5-alkyl (especially n-propyl, n-butyl, or n-pentyl) which is substituted with hydroxy and RA1, wherein said substituents are both at position 3 with respect to the point of attachment of said C3-5-alkyl to the rest of the molecule; wherein

[0239] > RA1represents

[0240] ■phenyl which is unsubstituted or mono-substituted with fluorine (especially 3-fluoro-phenyl) or Ci-3-alkoxy (especially 2-methoxy-phenyl or 4-methoxy-phenyl);

[0241] ■6-membered heteroaryl containing one or two ring nitrogen heteroatom(s) (notably pyridin- 2-yl, pyridin-3-yl, pyrimidin-2-yl, pyrazin-2-yl, or pyrimidin-4-yl), wherein said 5- or 6- membered heteroaryl is independently unsubstituted, mono- or di- substituted, and wherein the substituent(s), if any, is(are) independently selected from Ci-3-alkyl (especially methyl), C3-5-cycloalkyl (especially cyclopropyl), or Ci_3-alkoxy (especially methoxy); or

[0242] [in particular such C3-5-alkyl which represents 3-hydroxy-3-phenyl-propyl, 3-hydroxy-3-phenyl-butyl, 3-hydroxy- 3-(3-fluoro-phenyl)-butyl, 3-hydroxy-3-(2-methoxy-phenyl)-butyl, 3-hydroxy-3-(4-methoxy-phenyl)-butyl, 3- hydroxy-3-(6-methoxy-pyridin-2-yl)-butyl, 3-hydroxy-3-(5-methyl-pyridin-3-yl)-butyl, 3-hydroxy-3-(pyridin-2-yl)- butyl, 3-hydroxy-3-(6-methyl-pyridin-2-yl)-butyl, 3-hydroxy-3-(pyrimidin-2-yl)-butyl, 3-hydroxy-3-(6-methoxy- pyrimidin-4-yl)-butyl, 3-hydroxy-3-(6-methyl-pyrimidin-4-yl)-pentyl, 3-hydroxy-3-(2-methyl-pyrimidin-4-yl)- butyl, 3-hydroxy-3-(5-methyl-pyrazin-2-yl)-butyl, 3-hydroxy-3-(pyridin-2-yl)-pentyl, or 3-hydroxy-3-(6-methoxy- pyridin-2-yl)-pentyl]

[0243] 9) Another embodiment relates to compounds according to any one of embodiments 1) to 4), wherein said substituent of A / at least one of said substituents of A is

[0244] • -NRN3RN4, wherein RN3and RN4form, together with the nitrogen to which they are attached, a heterocyclic ring as defined in embodiment 1).

[0245] 10) Another embodiment relates to compounds according to embodiment 9), wherein said substituent of A / at least one of said substituents of A is

[0246] • -NRN3RN4wherein

[0247] > RN3and RN4form, together with the nitrogen to which they are attached, a heterocyclic ring of 4 to 6 members (notably 5 to 6 members), wherein the members needed to complete said heterocyclic ring are each independently selected from -CH2-, -0-, -(C=0)-, -CHRX- and -C(RY)2-; wherein said heterocyclic ring does not contain more than one member independently selected from the group consisting of -O- and -(C=0)-; wherein said heterocyclic ring does not contain more than two members selected from the group consisting of -CHRX-; and wherein said heterocyclic ring does not contain more than two members selected from the group consisting of -C(RY)2-; wherein Rxindependently represents fluorine, methyl, isopropyl, hydroxy, trifluoromethyl, cyclopropyl, phenyl, 3- methyl-1 ,2,4-oxadiazol-5-yl; and wherein RYindependently represents fluorine, hydroxy, cyclopropyl, methyl, or trifluoromethyl [notably such -NRN3RN4is pyrrolidinyl; 2-pyrrolidonyl; oxazolidinonyl (especially 1,3-oxazolidin-2-on-3-yl); piperidinyl; or morpholinyl, optionally independently substituted with one or two substituents independently selected from a group consisting of Rxand R11].

[0248] [in particular such -NRN3RN4represents pyrrolidin-1-yl, 3-fluoro-pyrrolidin-1-yl, 3,3-difluoro-pyrrolidin-1-yl, 3,4- difluoro-pyrrolidin-1-yl, 3-isopropyl-pyrrolidin-1-yl, 3,3-dimethyl-pyrrolidin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 2- methyl-pyrrolidin-1-yl, 3-hydroxy-3-methyl-pyrrolidin-1-yl, 3-hydroxy-3-trifluoromethyl-pyrrolidin-1-yl, 3- trifluoromethyl-pyrrolidin-1-yl, morpholin-4-yl, 3-(tetrahydropyran-4-yl)-pyrrolid-2-on-1-yl, pyrrolidin-2-on-1-yl, 4-phenyl-pyrrolidin-2-on-1-yl, 4-(pyridin-2-yl)-pyrrolidin-2-on-1-yl, 4-(6-methyl-pyridin-3-yl)-pyrrolidin-2-on-1-yl, 4-(2-isopropyl-pyrimidin-4-yl)-pyrrolidin-2-on-1-yl, 4-(6-isopropyl-pyridin-2-yl)-pyrrolidin-2-on-1-yl, 4-(6- trifluoromethyl-pyridin-3-yl)-pyrrolidin-2-on-1-yl, 4-methyl-pyrrolidin-2-on-1-yl, 4-isopropyl-pyrrolidin-2-on-1-yl, 3-isopropyl-pyrrolidin-2-on-1-yl, 3,3-dimethyl-pyrrolidin-2-on-1-yl, 4,4-dimethyl-pyrrolidin-2-on-1-yl, 3- (piperidin-4-yl)-pyrrolidin-2-on-1-yl, 4-(6-isopropyl-pyridin-2-yl)-pyrrolidin-2-on-1-yl, 4-isobutyl-pyrrolidin-2-on- 1-yl, 4-cyclopropyl-pyrrolidin-2-on-1-yl, 4-trifluoromethyl-pyrrolidin-2-on-1-yl, 2,2,6,6-tetrafluoro-morpholin-4- yl, 2,6-dimethyl-morpholin-4-yl, 3-(3-methyl-1,2,4-oxadiazol-5-yl)-pyrrolidin-1-yl, or 3-(phenyl)-pyrrolidin-1-yl] 11) Another embodiment relates to compounds according to any one of embodiments 1) to 4), wherein said substituent of A / at least one of said substituents of A is

[0249] > 5- or 6-membered heteroaryl as defined in embodiment 1 ), wherein the substituent(s) of said 5- or 6-membered heteroaryl, if any, is(are) independently selected from

[0250] > Ci-4-alkyl as defined in embodiment 1).

[0251] 12) Another embodiment relates to compounds according to embodiment 11), wherein said substituent of A / at least one of said substituents of A is

[0252] > 5- or 6-membered heteroaryl containing from one to three (notably two or three; especially three) ring heteroatom(s) independently selected from nitrogen, oxygen and sulfur (notably pyrazolyl, oxazolyl, thiazolyl, oxadiazolyl, pyrimidinyl, or pyridinyl; especially pyrazol-1-yl, 1 H-1 ,2,3-triazol-1 -yl, oxazol-2-yl, thiazol-2-yl, 1,2,4-oxadiazol-5-yl, 1,2,4-oxadiazol-3-yl, pyrimidin-2-yl, or pyridin-2-yl; notably 1,2,4-oxadiazol-5-yl or 1,2,4- oxadiazol-3-yl; especially 1,2,4-oxadiazol-3-yl); wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono-, di-, or tri-substituted (notably mono-substituted; especially mono-substituted in position 3 with respect to the point of attachment of said 5- or 6-membered heteroaryl to A), wherein the substituent(s), if any, is(are) independently selected from

[0253] > Ci-4-alkyl (especially methyl, ethyl, propyl, isopropyl, or tert-butyl) which is

[0254] ■unsubstituted;

[0255] ■mono-substituted with

[0256] ❖ hydroxy; or

[0257] ❖ Ci_4-alkoxy (especially methoxy and tert-butoxy); or

[0258] [in particular such Ci-4-alkyl represents methyl, isopropyl, hydroxy-methyl, 1-hydroxy-1- methyl-ethyl, 2-hydroxy-2-methyl-propyl, 2-hydroxy-1 , 1 -dimethyl-ethyl, methoxy- methyl, 2-methoxy-ethyl, 1 -methoxy-1 -methyl-ethyl, 2-methoxy-2-methyl-propyl, 2- methoxy-1 , 1 -dimethyl-ethyl, or tert-butoxy-methyl; in particular such C -alkyl represents 1 -hydroxy-1 -methyl-ethyl, 2-hydroxy-2-methyl-propyl, or 2-hydroxy-1,1- dimethyl-ethyl]

[0259] ■di-substituted, wherein one substituent is hydroxy, and another substituent is trifluoromethyl; or two substituents are hydroxy;

[0260] ■di- or tri-substituted, wherein two substituents are fluorine and, if present, one substituent is hydroxy (wherein the hydroxy group is separated by at least two carbon atoms from any of said fluorine substituents);

[0261] [in particular such C -alkyl represents methyl, isopropyl, hydroxy-methyl, 1-hydroxy-1-methyl-ethyl,

[0262] 2-hydroxy-2-methyl-propyl, 2-hydroxy-1 , 1 -dimethyl-ethyl, methoxy-methyl, 2-methoxy-ethyl, 1- methoxy-1 -methyl-ethyl, 2-methoxy-2-methyl-propyl, 2-methoxy-1, 1-dimethyl-ethyl, tert-butoxy- methyl; 1,2-dihydroxy-ethyl, N-acetyl-2-amino-ethyl, N-(acetyl-2,2,2-d3)-2-amino-ethyl, 2- (methylcarboxamido)-2-methyl-propyl, 2-(ethylcarboxamido)-2-methyl-propyl, 2-(cyclopropyl- carboxamido)-2-methyl-propyl, 2-(tetrahydropyran-4-yl-carboxamido)-2-methyl-propyl, 2-(methoxy- methyl-carboxamido)-2-methyl-propyl, 2-(ethyl-carboxamido)-2-methyl-propyl, 2-(isopropyl- carboxamido)-2-methyl-propyl, 2-(methyl-d3-carboxamido)-2-methyl-propyl, N-methyl-N-(hydroxy- methyl-carbonyl)-2-amino-ethyl, N-methyl-N-acetyl-2-amino-ethyl, 2, 2, 2-trifluoro-1 -hydroxy-1 - methyl-ethyl, 1 , 1 -difluoro-2-hydroxy-ethyl, 1,1-difluoro-ethyl, or N-methyl-N-(acetyl-2,2,2-d3)-2- amino-ethyl; in particular such C -alkyl group is 1 -hydroxy-1 -methyl-ethyl, 2-hydroxy-2-methyl- propyl, or 2-hydroxy-1 , 1 -dimethyl-ethyl]

[0263] 13) Another embodiment relates to compounds according to embodiment 11), wherein said substituent of A / at least one of said substituents of A is

[0264] > 1,2,4-oxadiazol-5-yl or 1,2,4-oxadiazol-3-yl (especially 1,2,4-oxadiazol-3-yl), wherein said oxadiazolyl groups are mono-substituted, wherein the substituent is independently selected from

[0265] > Ci-4-alkyl (especially methyl, ethyl, propyl, isopropyl, ot tetrt-butyl) which is

[0266] ■mono-substituted with

[0267] ❖ hydroxy; or

[0268] ❖ Ci-4-alkoxy (especially methoxy and tert-butoxy).

[0269] [in particular such Ci_4-alkyl represents hydroxy-methyl, 1 -hydroxy-1 -methyl-ethyl, 2- hydroxy-2-methyl-propyl, 2-hydroxy-1 , 1 -dimethyl-ethyl, methoxy-methyl, 2-methoxy- ethyl, 1 -methoxy-1 -methyl-ethyl, 2-methoxy-2-methyl-propyl, 2-methoxy-1 , 1 -dimethyl- ethyl, or tert-butoxy-methyl; in particular such C -alkyl represents 1 -hydroxy-1 -methyl- ethyl, 2-hydroxy-2-methyl-propyl, or 2-hydroxy-1 , 1 -dimethyl-ethyl]

[0270] 14) Another embodiment relates to compounds according to embodiment 11), wherein said substituent of A / at least one of said substituents of A is

[0271] > 1 , 2 , 4-oxad i azo I -3-y I , which is mono-substituted (especially in position 3 with respect to the point of attachment of said oxadiazolyl to A), wherein the substituent is

[0272] > Ci-4-alkyl (especially methyl, ethyl, propyl, isopropyl, or tert-butyl) which is

[0273] ■mono-substituted with

[0274] ❖ hydroxy;

[0275] [in particular such C -alkyl represents hydroxy-methyl, 1 -hydroxy-1 -methyl-ethyl, 2- hydroxy-2-methyl-propyl, 2-hydroxy-1 , 1 -dimethyl-ethyl, in particular such C -alkyl represents 1 -hydroxy-1 -methyl-ethyl, 2-hydroxy-2-methyl-propyl, or 2-hydroxy-1 ,1- dimethyl-ethyl]

[0276] 15) Another embodiment relates to compounds according to embodiment 11), wherein A represents pyridin-3-yl, wherein said pyridin-3-yl is mono-substituted in eia-position with respect to the point of attachment of said pyridin-3- yl to the rest of the molecule, wherein the substituent is

[0277] > 1 , 2 , 4-oxad i azo I -3-y I , which is mono-substituted (especially in position 3 with respect to the point of attachment of said oxadiazolyl to A), wherein the substituent is hydroxy-methyl, 1 -hydroxy- 1 -methyl-ethyl, 2-hydroxy-2- methyl-propyl, or 2-hydroxy-1 , 1 -dimethyl-ethyl.

[0278] [in particular such 1,2,4-oxadiazol-3-yl represents 5-(hydroxy-methyl)-1,2,4-oxadiazol-3-yl, 5-(1 -hydroxy-1 - methyl-ethyl)-1,2,4-oxadiazol-3-yl, 5-(2-hydroxy-2-methyl-propyl)-1,2,4-oxadiazol-3-yl, or 5-(2-hydroxy-1,1- dimethyl-ethyl)-1,2,4-oxadiazol-3-yl]

[0279] 16) Another embodiment relates to compounds according to any one of embodiments 1) to 4), wherein said substituent of A / at least one of said substituents of A is

[0280] > 5- or 6-membered heteroaryl as defined in embodiment 1 ), wherein the substituent(s) of said 5- or 6-membered heteroaryl, if any, is(are) independently selected from

[0281] > -L3-CY3as defined in embodiment 1).

[0282] 17) Another embodiment relates to compounds according to embodiment 16), wherein said substituent of A / at least one of said substituents of A is

[0283] • 5- or 6-membered heteroaryl containing from one to three (notably two or three; especially three) ring heteroatom(s) independently selected from nitrogen, oxygen and sulfur (notably pyrazolyl, oxazolyl, thiazolyl, oxadiazolyl, pyrimidinyl, or pyridinyl; especially pyrazol-1-yl, 1 / 7-1,2,3-triazol-1-yl, oxazol-2-yl, thiazol-2-yl, 1,2,4-oxadiazol-5-yl, 1,2,4-oxadiazol-3-yl, pyrimidin-2-yl, or pyridin-2-yl; notably 1,2,4-oxadiazol-5-yl or 1,2,4- oxadiazol-3-yl; especially 1,2,4-oxadiazol-3-yl); wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono-, di-, or tri-substituted (notably mono-substituted; especially mono-substituted in position 3 with respect to the point of attachment of said 5- or 6-membered heteroaryl to A), wherein the substituent(s), if any, is(are) independently selected from

[0284] > -L3-CY3, wherein

[0285] ■-L3- independently represents a bond (i.e. the CY3is directly attached to the rest of the molecule), -CH2-, -CH2-CH2-, -C(CH3)2-, -CH(OH)-, or -0-CH2-, wherein when -L3- is -O- CH2-, said CY3is attached to the oxygen atom of said -0-CH2-; and

[0286] ■CY3independently represents piperidinyl; wherein said piperidinyl independently is unsubstituted, mono-, di-, or tri-substituted as defined in embodiment 1). 18) Another embodiment relates to compounds according to embodiment 16), wherein said substituent of A / at least one of said substituents of A is

[0287] > 1,2,4-oxadiazol-5-yl or 1,2, 4-oxad i azol -3-y I (especially 1,2,4-oxadiazol-3-yl), wherein said oxadiazolyl groups are mono-substituted, wherein the substituent is independently selected from • -L3-CY3, wherein

[0288] ■-L3- independently represents a bond (i.e. the CY3is directly attached to the rest of the molecule), -CH2-, -CH2-CH2-, -C(CH3)2-, -CH(OH)-, or -O-CH2-, wherein when -L3- is -0- CH2-, said CY3is attached to the oxygen atom of said -O-CH2-; and

[0289] ■CY3independently represents piperidinyl (notably piperidin-2-yl, piperidin-3-yl, or piperidin- 4-yl; especially piperidin-4-yl) wherein said piperidinyl independently is unsubstituted, mono- , di-, or tri-substituted (especially unsubstituted, mono-, or di-substituted) with

[0290] > halogen (especially fluorine);

[0291] > oxo;

[0292] > hydroxy;

[0293] > Ci-3-alkyl which is optionally mono-substituted with Ci-3-alkoxy (especially such Ci_ 3-alkyl represents methyl, ethyl, propyl, isopropyl, or methoxy-methyl);

[0294] > Ci-3-alkoxy (especially methoxy);

[0295] > -(C=0)-Rco, wherein Rcorepresents o Ci-3-alkyl which is optionally mono-substituted with hydroxy or Ci-3-alkoxy (especially methyl, ethyl, n-propyl, isopropyl, tert-butyl, hydroxy-methyl, methoxy-methyl, benzyl-oxy, or 2-methoxy-ethyl; in particular said - (C=0)-R¥ is acetyl); o Ci-3-fluoroalkyl (especially 2, 2 , 2-trif I u 0 ro-ethy I ) ; o Ci-3-alkoxy (especially methoxy); o C3-6-cycloalkyl-(CH2)n-, wherein optionally one or two carbon ring atom(s) is / are replaced by one or two oxygen ring atom(s); wherein n represents the integer 0, or 1 (especially such C3-5-cycloalkyl-(CH2)n- represents cyclopropyl, cyclopentyl, oxetan-3-yl, oxetan-3-yl-methyl, 1,4-dioxan-2-yl, or tetrahydropyran-4-yl); or o phenyl;

[0296] [especially such -(C=0)-Rcorepresents acetyl, ethyl-carbonyl, n-propyl -carbonyl , isopropyl-carbonyl, tert-butyl-carbonyl, hydroxymethyl-carbonyl, 2,2,2-trifluoro- ethyl-carbonyl, methoxy-methyl-carbonyl, 2-methoxy-ethyl-carbonyl, methoxy- carbonyl, ethoxy-carbonyl, 2-methoxy-ethoxy-carbonyl, cyclopropyl-carbonyl, cyclopentyl-carbonyl, oxetan-3-yl-carbonyl, oxetan-3-yl-methyl-carbonyl, phenyl- carbonyl, or tetrahyd ropy ran -4-y I -car bo ny I , methoxy-methyl-carbonyl, or 1,4- dioxan-2-yl-carbonyl]

[0297] > -S(=0)2-Rso, wherein Rsorepresents o Ci-3-alkyl which is optionally mono-substituted with hydroxy, Ci-3-alkoxy, or amino (especially methyl, n-propyl, isopropyl, 2-hydroxy-ethyl, 2- methoxy-ethyl, or methyl-amino); or o C3-5-cycloalkyl, wherein optionally one carbon ring atom is replaced by one oxygen ring atom (especially represents cyclopropyl, cyclopentyl, or tetrahydropyran-4-yl);

[0298] [especially such -S(=0)2-Rsorepresents methyl-sulfonyl, n-propyl-sulfonyl, isopropyl-sulfonyl, 2-hydroxyethyl-sulfonyl, cyclopropyl-sulfonyl, cyclopentyl- sulfonyl, 2-methoxy-ethyl-sulfonyl, methyl-amino-sulfonyl, or tetrahydropyran-4-yl- sulfonyl]

[0299] [in particular such — L3— CY3piperidin-4-yl, 1-methyl-2,6-dioxo-piperidin-4-yl, 4-methyl-piperidin-4-yl, 4-fl uoro-pi perid i n-4-y 1 , 2-oxo-piperidin-4-yl, 6-oxo-piperidin-2-yl, 6-oxo-pi peridi n-3-yl , 1-methyl-6-oxo- piperidin-3-yl, 3-methyl-6-oxo-piperidin-3-yl, N-acetyl-piperidin-4-yl, N-acetyl-piperidin-4-yl-methyl, N-acetyl-2-methyl-piperidin-4-yl, N-acetyl-4-fluoro-piperidin-4-yl, N-acetyl-3-methyl-piperidin-4-yl, N- acetyl-4-methyl-piperidin-4-yl, N-acetyl-4-hydroxy-piperidin-4-yl, N-acetyl-4-methoxy-piperidin-4-yl, N-acetyl-piperidin-3-yl, N-acetyl-piperidin-3-yl-methyl, N-acetyl-3-methyl-piperidin-3-yl, N-acetyl-3- hydroxy-piperidin-3-yl, N-(isopropyl-carbonyl)-4-hydroxy-piperidin-4-yl, N-(tert-butyl-carbonyl)- piperidin-4-yl, N-(2-methoxy-ethoxy-carbonyl)-piperidin-4-yl, N-(hydroxymethyl-carbonyl)-piperidin- 4-yl, N-(cyclopropyl-sulfonyl)-piperidin-4-yl, N-(methyl-sulfonyl)-piperidin-4-yl, N-(n-propyl-sulfonyl)- piperidin-4-yl, N-(isopropyl-sulfonyl)-piperidin-4-yl, N-(2-hydroxy-ethyl-sulfonyl)-piperidin-4-yl, N- (cyclopentyl-sulfonyl)-piperidin-4-yl, N-(methoxy-carbonyl)-piperidin-4-yl, N-(cyclopropyl-carbonyl)- piperidin-4-yl, N-(cyclopentyl-carbonyl)-piperidin-4-yl, N-(methyl-amino-sulfonyl)-piperidin-4-yl, N-(2- methoxy-ethyl-sulfonyl)-piperidin-4-yl, N-(ethyl-carbonyl)-4-hydroxy-piperidin-4-yl, N-(methoxy- methyl-carbonyl)-piperidin-4-yl, N-(ethoxy-carbonyl)-piperidin-4-yl, N-acetyl-4-ethyl-piperidin-4-yl, N- (n-propyl-carbonyl)-piperidin-4-yl, N-(2-methoxy-ethyl-carbonyl)-piperidin-4-yl, N-(oxetan-3-yl- carbonyl)-piperidin-4-yl, N-(oxetan-3-yl-methyl-carbonyl)-piperidin-4-yl, N-(2,2,2-trifluoro-ethyl- carbonyl)-piperidin-4-yl, N-(tetrahydropyran-4-yl-carbonyl)-piperidin-4-yl, N-(phenyl-carbonyl)- piperidin-4-yl, N-(tetrahydropyran-4-yl-sulfonyl)-piperidin-4-yl, N-(benzyl-oxy-carbonyl)-piperidin-4-yl, N-(methoxy-methyl-carbonyl)-4-isopropyl-piperidin-4-yl, N-(1,4-dioxan-2-yl-carbonyl)-piperidin-4-yl],

[0300] 19) Another embodiment relates to compounds according to embodiment 16), wherein said substituent of A / at least one of said substituents of A is

[0301] > 1,2,4-oxadiazol-3-yl, wherein said oxadiazolyl group is mono-substituted, wherein the substituent is independently selected from • -L3-CY3, wherein

[0302] ■-L3-represents a bond (i.e. the CY3is directly attached to the rest of the molecule); and

[0303] ■CY3independently represents piperidin-4-yl which is unsubstituted, or mono- or di- substituted, wherein

[0304] > one substituent is attached to the nitrogen atom of said piperidine ring, wherein the substituent is -(C=0)-Rco, wherein Rcorepresents o Ci-3-alkyl optionally mono-substituted, wherein the substituent represents Ci-3-alkoxy or hydroxy (especially such Ci-3-alkyl is methyl, ethyl, n-propyl, isopropyl, tert-butyl, hydroxy-methyl, methoxy-methyl, or 2-methoxy-ethyl; in particular said -(C=0)-Rcois acetyl); o Ci-3-fluoroalkyl (especially 2,2,2-trifluoro-ethyl); o Ci-3-alkoxy (especially methoxy); o C3-6-cycloalkyl-(CH2)n-, wherein optionally one or two carbon ring atom(s) is / are replaced by one or two oxygen ring atom(s); wherein n represents the integer 0, or 1 (especially such C3_5-cycloal kyl-(CH2)n- represents cyclopropyl, cyclopentyl, oxetan-3-yl, oxetan-3-yl-methyl, 1,4-dioxan-2-yl, or tetrahydropyran-4-yl); or

[0305] [especially such -(C=0)-Rcorepresents acetyl, ethyl-carbonyl, n-propyl-carbonyl, isopropyl-carbonyl, tert-butyl-carbonyl, hydroxymethyl-carbonyl, 2,2,2-trifluoro- ethyl-carbonyl, methoxy-methyl-carbonyl, 2-methoxy-ethyl-carbonyl, methoxy- carbonyl, ethoxy-carbonyl, 2-methoxy-ethoxy-carbonyl, cyclopropyl-carbonyl, cyclopentyl-carbonyl, oxetan-3-yl-carbonyl, oxetan-3-yl-methyl-carbonyl, tetrahydropyran-4-yl-carbonyl, methoxy-methyl-carbonyl, or 1,4-dioxan-2-yl- carbonyl]

[0306] > and / or one substitutent is attached to a carbon atom of the piperidine ring, wherein said substituent is Ci-3-alkyl (especially methyl), halogen (especially fluorine), hydroxy, or C1-3- alkoxy (especially methoxy). 20) Another embodiment relates to compounds according to any one of embodiments 1) to 4), wherein said substituent of A / at least one of said substituents of A independently is

[0307] • -CºC-RT1; or

[0308] • -CºC-C(OH)(RT2)(RT3); wherein said groups are as defined in embodiment 1).

[0309] 21) Another embodiment relates to compounds according to embodiment 20), wherein said substituent of A / at least one of said substituents of A is

[0310] • -CºC-RT1, wherein

[0311] > RT1represents

[0312] ■Ci-4-alkyl (notably methyl, ethyl, isopropyl, or isobutyl), wherein said C -alkyl independently is mono-substituted with

[0313] ❖ hydroxy;

[0314] [especially such C -alkyl represents hydroxy-methyl, 1 -hydroxy-ethyl, 2-hydroxy-ethyl, 1- hyd roxy-2-methy I - pro py I , or 1 -hydroxy-1 -methyl-ethyl];

[0315] ❖ Ci_3-alkoxy (especially methoxy);

[0316] ❖ -S(=0)2-Rsot, wherein RS0Trepresents Cu-alkyl, Ci-3-alkyl-amino, or C3-5- cycloalkyl (especially such -S(=0)2-RS0Trepresents methyl-sulfonyl, methyl- amino-sulfonyl or cyclopropyl-sulfonyl);

[0317] ❖ C4-6-heterocyclyl containing one or two ring heteroatom(s) independently selected from nitrogen and oxygen (notably oxazolidinyl, imidazolidinyl, or pyrrolidinyl; especially oxazolidin-3-yl, imidazolidin-3-yl, or pyrrolidin-1-yl); wherein said C4-6- heterocyclyl is mono-substituted with oxo; or di-substituted with oxo and one C1-3- alkyl (especially methyl); (especially such C4-6-heterocyclyl represents oxazolidin- 2-on-3-yl, imidazolidin-2-on-3-yl, 1-methyl-imidazolidin-2-on-3-yl, or pyrrolidin-2- on-1-yl);

[0318] ■Ci-4-alkyl (notably methyl, ethyl, isopropyl, or isobutyl) which is independently di-substituted, wherein one substituent is hydroxy, and a second substituent is trifluoromethyl (especially 1 -hydroxy-1 -trifluoromethyl-ethyl);

[0319] ■C3-6-cycloalkyl (especially cyclopropyl) which is mono-substituted (especially at the point of attachment of the C3-6-cycloalkyl to the rest of the molecule) with

[0320] ❖ hydroxy;

[0321] ❖ amino-sulfonyl which is optionally di-substituted with methyl;

[0322] ❖ phenyl which is mono-substituted with halogen (especially 4-fluoro-phenyl); ❖ pyridinyl (especially pyridine-2-yl);

[0323] ❖ pyrimidinyl which is mono-substituted with Ci_3-alkyl (especially 6-methyl-pyrimidin- 4-yl);

[0324] ❖ oxazolidinonyl (especially oxazolidin-2-on-3-yl);

[0325] [in particular such C3-6-cycloalkyl represents 1 -hydroxy-cyclopropyl, 1 -hydroxy-cyclobutyl, 1- hydroxy-cyclopenty, 1 -(amino-sulfonyl)-cyclopropyl, 1 -(dimethyl-amino-sulfonyl)- cyclopropyl, 1-(6-methyl-pyrimidin-4-yl)-cyclopropyl, 1-(pyridine-2-yl)-cyclopropyl, 1-(4- fluoro-phenyl)-cyclopropyl, 1-(pyridine-2-yl)-cyclopropyl, or 1-(oxazolidin-2-on-3-yl)- cyclopropyl];

[0326] ■C4-6-heterocyclyl containing one ring heteroatom independently selected from nitrogen and oxygen (notably azetidinyl, pyrrolidinyl, piperidinyl, tetrahydropyranyl; especially azetidin-3- yl, piperidin-4-yl, pyrrolidin-3-yl, pyrrolidin-2-yl, pyrrolidine-1-yl, or tetrahydropyran-4-yl); wherein said C4-6-heterocyclyl is mono-, di-, or tri-substituted (especially mono- or di- substituted), wherein the substituent(s) is(are) independently selected from Ci-3-alkyl (especially methyl), hydroxy, oxo, Ci-3-alkyl-carbonyl (especially acetyl), Ci_3-alkoxy- carbonyl (especially tert-butoxy-carbonyl), Ci-3-alkyl-sulfonyl (especially methyl-sulfonyl), and Ci-3-alkyl-amino-sulfonyl (especially methyl-amino-sulfonyl);

[0327] [in particular such C4-6-heterocyclyl represents N-(isopropyl-carbonyl)-3-hydroxy-azetidin-3- yl, N-(tert-butoxy-carbonyl)-3-hydroxy-azetidin-3-yl, N-methyl-3-hydroxy-pyrrolidin-2-one-3- yl, N-acetyl-2-methyl-pyrrolidin-2-yl, 3-hydroxy-N-(tert-butoxy-carbonyl)-pyrrolidin-3-yl, 2- oxo-pyrrolidine-1-yl, N-acetyl-piperidin-4-yl, N-acetyl-4-methyl-piperidin-4-yl, N-(methyl- amino-sulfonyl)-4-methyl-piperidin-4-yl, N-acety l-4-hydroxy-pi peri di n-4-yl , N-(methyl- sulfonyl)-piperidin-4-yl, N-(tert-butoxy-carbonyl)-piperidin-4-yl, 3-hydroxy-2-oxo-1-methyl- pyrrolidin-2-yl, or 4-hydroxy-tetrahydropyran-4-yl);

[0328] ■indolyl (especially indol-2-yl);;

[0329] ■3-hydroxy-1 -methyl-1, 3-dihydro-indol-2-on-3-yl; or

[0330] [in particular such -CºC-RT1represents 3-hydroxy-3-trifluoromethyl-but-1-yn-1-yl, 3-hydroxy-prop-1 -yn-1 -yl, 4- hydroxy-but-1 -yn-1 -yl, 3-hydroxy-but-1-yn-1-yl, 3-hydroxy-3-methy l-but- 1 -y n- 1 -y 1 , 3-hydroxy-4-methyl-pent-1- yn-1-yl, (l-hydroxy-cyclopropyl)-ethynyl, (l-hydroxy-cyclobutyl)-ethynyl, (l-hydroxy-cyclopentyl)-ethynyl, (8- hydroxy-5,6,7,8-tetrahydroquinolin-8-yl)-ethynyl, (7-hydroxy-6,7-dihydro-5H-cyclopenta[b] pyridin-7-yl)- ethynyl, (4-hydroxy-tetrahydropyran-4-yl)-ethynyl, (1-(isopropyl-carbonyl)-3-hydroxy-azetidin-3-yl)-ethynyl, (1- (tert-butoxy-carbonyl)-3-hydroxy-azetidin-3-yl)-ethynyl, (N-acetyl-4-hydroxy-piperidin- (3-hydroxy-N-(tert- butoxy-carbonyl)-pyrrolidin-3-yl)-ethynyl, (3-hydroxy- 1 -methyl-1, 3-dihydro-indol-2-on-3-yl)-ethynyl, or (3- hydroxy-2-oxo-1-methyl-pyrrolidin-3-yl)-ethynyl]

[0331] • -CºC-C(OH)(RT2)(RT3) is as defined in embodiment 1).

[0332] 22) Another embodiment relates to compounds according to embodiment 20), wherein said substituent of A / at least one of said substituents of A is

[0333] • -CºC-C(OH)(RT2)(RT3), wherein

[0334] > RT2represents hydrogen or Ci-3-alkyl (notably methyl or ethyl; especially methyl);

[0335] > RT3represents

[0336] ■6-membered heteroaryl containing one or two ring nitrogen atoms (especially pyridinyl, pyrazinyl, or pyrimidinyl; especially pyridin-2-yl, pyrimidin-2-yl, pyrazin-2-yl, or pyrimidin-4- yl; in particular pyrimidin-4-yl), wherein said 6-membered heteroaryl is independently unsubstituted, mono- or di- substituted; wherein the substituent(s), if any, is(are) independently selected from Ci_3-alkyl (especially methyl), Ci_3-cycloalkyl (especially cyclopropyl), Ci_3-fluoroalkyl (notably Crfluoroalkyl; especially difluoromethyl or trifluoromethyl), and Ci-3-alkoxy (especially methoxy);

[0337] [in particular such 6-membered heteroaryl is pyridin-2-yl, 6-methoxy-pyridin-2-yl, 6-methyl- pyridin-2-yl, pyrimidin-2-yl, 2-methoxy-pyrimidin-4-yl, 6-methoxy-py rimi di n-4-yl , pyrimidin-4- yl, 2-methyl-pyrimidin-4-yl, 6-methyl-pyrimidin-4-yl, 2,6-dimethyl-pyrimidin-4-yl, 2,6- dimethoxy-pyrimidin-4-yl, 2-methyl-6-methoxy-pyrimidin-4-yl, 2-methoxy-6-methyl- pyrimidin-4-yl, 5-methyl-pyrazin-2-yl, 6-cyclopropyl-pyrimidin-4-yl, 6-difluoromethyl- pyrimidin-4-yl, 2-trifluoromethyl-pyrimidin-4-yl, or 6-trifluoromethyl-pyrimidin-4-yl]

[0338] [in particular such -CºC-C(OH)(RT2)(RT3) represents 3-hydroxy-3-(pyrimidin-2-yl)-but-1-yn-1-yl, 3-hydroxy-3-(6- methyl-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(2-methoxy-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(2- methoxy-6-methyl-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(6-methoxy-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy- 3-(2,6-dimethoxy-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(2-methyl-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3- (6-methoxy-2-methyl-pyrimidin-4-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(pyridin-2-yl)-pent-1-yn-1-yl, 3-hydroxy-3-(6- methoxy-pyridin-2-yl)-but-1-yn-1-yl, 3-hydroxy-3-(6-methyl-pyridin-2-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(6-methyl- pyridin-2-yl)-pent-1 -yn-1 -yl, 3-hydroxy-3-(2,6-dimethyl-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(6-methoxy- pyridin-2-yl)-pent-1-yn-1-yl, 3-hydroxy-3-(6-cyclopropyl-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(6- difluoromethyl-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(2-trifluoromethyl-pyrimidin-4-yl)-but-1 -yn-1 -yl, or 3- hydroxy-3-(6-trifluoromethyl-pyrimidin-4-yl)-but-1-yn-1-yl] 23) Another embodiment relates to compounds according to any one of embodiments 1) to 22), wherein B represents phenyl, which is mono-, di- or tri-substituted, wherein a first substituent is attached in para- position with respect to the point of attachment of B to the rest of molecule, wherein said substituent is selected from

[0339] > Ci-5-alkyl (notably methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, 1 -ethyl-propyl, 2,2-dimethyl- propyl, 1,1 -dimethyl-propyl; especially methyl, ethyl, or isopropyl; in particular isopropyl);

[0340] > Ci-3-alkoxy-Ci-4-alkyl (especially 3-methoxy-propyl);

[0341] > Ci-2-fluoroalkyl (especially trifluoromethyl or 2,2,2-trifluoro-ethyl);

[0342] > C3-5-cycloalkyl (especially cyclopropyl or cyclobutyl) which independently is unsubstituted or mono-substituted (notably at the point of attachment of said C3-5-cycloalkyl to the rest of the molecule) with Ci-3-alkyl (especially methyl) or Ci_3-fluoroal kyl (especially trifluoromethyl); and

[0343] > Crfluoroalkoxy (especially trifluoromethoxy); and the remaining substituent(s) of B (wherein especially said remaining substituent(s) is / are attached in eia-position with respect to the point of attachment of B to the rest of molecule), if present, independently is / are selected from halogen (notably fluorine or chlorine; especially fluorine).

[0344] [in particular such group B represents 4-methyl-phenyl, 4-ethyl-phenyl, 4-propyl-phenyl, 4-isopropyl-phenyl, 4-butyl- phenyl, 4-isobutyl-phenyl, 4-tert-butyl-phenyl, 4-(1-ethyl-propyl)-phenyl, 4-(1,1-dimethyl-propyl)-phenyl, 4-(2,2- dimethyl-propyl)-phenyl, 3-chloro-4-isopropyl-phenyl, 3-fl uoro-4-isopropy l-pheny 1 , 3,5-difluoro-4-isopropyl-phenyl, 4- cyclopropyl-phenyl, 4-trifluoromethyl-phenyl, 4-(2,2,2-trifluoro-ethyl)-phenyl, 4-trifluoromethoxy-phenyl, 4-(1-methyl- cyclopropyl)-phenyl, 4-cyclobutyl-phenyl, 4-(3-methoxy-propyl)-phenyl, or 4-(1-trifluoromethyl-cyclopropyl)-phenyl]

[0345] 24) Another embodiment relates to compounds according to any one of embodiments 1) to 22), wherein B represents phenyl, which is mono-, di- or tri-substituted, wherein a first substituent is attached in para- position with respect to the point of attachment of B to the rest of molecule, wherein said substituent is selected from

[0346] > C2-4-alkyl (notably n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl; in particular isopropyl);

[0347] > trifluoromethyl or 2,2,2-trifluoro-ethyl;

[0348] > C3-5-cycloalkyl (especially cyclopropyl or cyclobutyl) which independently is unsubstituted or mono-substituted (notably at the point of attachment of said C3-5-cycloalkyl to the rest of the molecule) with Ci_3-alkyl (especially methyl) or Ci-3-fluoroalkyl (especially trifluoromethyl); and

[0349] > Crfluoroalkoxy (especially trifluoromethoxy); and the remaining substituent(s) of B (wherein especially said remaining substituent(s) is / are attached in meia-position with respect to the point of attachment of B to the rest of molecule), if present, independently is / are selected from halogen (notably fluorine or chlorine; especially fluorine). [in particular such group B represents 4-propyl-phenyl, 4-isopropyl-phenyl, 4-butyl-phenyl, 4-isobutyl-phenyl, 4-tert- butyl-phenyl, 3-chloro-4-isopropyl-phenyl, 3-fluoro-4-isopropyl-phenyl, 3,5-difluoro-4-isopropyl-phenyl, 4-cyclopropyl- phenyl, 4-trifluoromethyl-phenyl, 4-trifluoromethoxy-phenyl, 4-(2,2,2-trifluoro-ethyl)-phenyl, 4-(1 -methyl-cyclopropyl)- phenyl, 4-cyclobutyl-phenyl, or 4-(1-trifluoromethyl-cyclopropyl)-phenyl]

[0350] 25) Another embodiment relates to compounds according to any one of embodiments 1) to 22), wherein B represents phenyl, which is mono-substituted, wherein the substituent is attached in para- position with respect to the point of attachment of B to the rest of molecule, wherein said substituent is selected from isopropyl (preferred), trifluoromethyl, trifluoromethoxy, trifluoromethyl, cyclopropyl, cyclobutyl, 1 -methyl-cyclopropyl, and 1-trifluoromethyl-cyclopropyl.

[0351] [in particular such group B represents 4-isopropyl-phenyl, 4-cyclopropyl-phenyl, 4-trifluoromethyl-phenyl, 4- trifluoromethoxy-phenyl, 4-(1-methyl-cyclopropyl)-phenyl, 4-cyclobutyl-phenyl, or 4-(1-trifluoromethyl-cyclopropyl)- phenyl]

[0352] 26) Another embodiment relates to compounds according to any one of embodiments 1) to 25), wherein R1represents Ci-3-alkyl (notably methyl or ethyl; especially methyl);

[0353] 27) Another embodiment relates to compounds according to any one of embodiments 1) to 26), wherein R2represents Ci-4-alkyl (especially methyl (preferred), ethyl, n-propyl, isopropyl, tert-butyl or isobutyl), C3-s-cycloalkyl (especially cyclopropyl or cyclobutyl), C3-5-cycloalkyl-Ci-3-alkyl (especially cyclopropyl-methyl), or Ci-3-fluoroalkyl (especially 2,2- difluoro-ethyl, or 2-fluoroethyl).

[0354] 28) Another embodiment relates to compounds according to any one of embodiments 1) to 26), wherein R2represents methyl (preferred), ethyl, n-propyl, isopropyl, cyclopropyl, or cyclobutyl.

[0355] 29) Another embodiment relates to compounds according to embodiment 1), wherein A represents pyridin-3-yl, wherein said pyridin-3-yl is mono-substituted in eia-position with respect to the point of attachment of said pyridin-3-yl to the rest of the molecule, wherein the substituent is 5-(hydroxy-methyl)-1,2,4-oxadiazol-3-yl, 5-(1-hydroxy-1-methyl-ethyl)- 1,2,4-oxadiazol-3-yl, 5-(2-hydroxy-2-methyl-propyl)-1,2,4-oxadiazol-3-yl, or 5-(2-hydroxy-1 , 1 -dimethyl-ethyl)-1 ,2,4- oxadiazol-3-yl;

[0356] B represents 4-propyl-phenyl, 4-isopropyl-phenyl, 4-isobutyl-phenyl, 4-tert-butyl-phenyl, 3-fluoro-4-isopropyl-phenyl, 3,5-difluoro-4-isopropyl-phenyl, 4-cyclopropyl-phenyl, 4-trifluoromethyl-phenyl, 4-trifluoromethoxy-phenyl, 4-(2,2,2- trifluoro-ethyl)-phenyl, 4-cyclobutyl-phenyl, or 4-(1-trifluoromethyl-cyclopropyl)-phenyl;

[0357] R1represents methyl; and R2represents methyl.

[0358] 30) Another embodiment relates to compounds according to embodiment 1), wherein A represents pyridin-3-yl, wherein said pyridin-3-yl is mono-substituted in eia-position with respect to the point of attachment of said pyridin-3-yl to the rest of the molecule, wherein the substituent is > 1 , 2 , 4-oxad i azol -3-y I , wherein said oxadiazolyl group is mono-substituted, wherein the substituent is piperidin- 4-yl which is unsubstituted, or mono- or di-substituted, wherein one substituent is attached to the nitrogen atom of said piperidine ring, wherein the substituent is

[0359] • acetyl, ethyl-carbonyl, n-propy I -carbonyl , isopropyl-carbonyl, tert-butyl-carbonyl, hydroxymethyl- carbonyl, 2,2,2-trifluoro-ethyl-carbonyl, methoxy-methyl-carbonyl, 2-methoxy-ethyl-carbonyl, methoxy-carbonyl, ethoxy-carbonyl, 2-methoxy-ethoxy-carbonyl, cyclopropyl-carbonyl, cyclopentyl- carbonyl, oxetan-3-yl-carbonyl, oxetan-3-yl-methyl-carbonyl, tetrahydropyran-4-yl-carbonyl, methoxy-methyl-carbonyl, or 1,4-dioxan-2-yl-carbonyl; and / or one substituent is attached to a carbon atom of the piperidine ring, wherein said substituent is Ci_3-alkyl (especially methyl), halogen (especially fluorine), hydroxy, or Ci-3-alkoxy (especially methoxy).

[0360] B represents 4-propyl-phenyl, 4-isopropyl-phenyl, 4-isobutyl-phenyl, 4-tert-butyl-phenyl, 3-fluoro-4-isopropyl-phenyl, 3,5-difluoro-4-isopropyl-phenyl, 4-cyclopropyl-phenyl, 4-trifluoromethyl-phenyl, 4-trifluoromethoxy-phenyl, 4-(2,2,2- trifluoro-ethyl)-phenyl, 4-cyclobutyl-phenyl, or 4-(1-trifluoromethyl-cyclopropyl)-phenyl;

[0361] R1represents methyl; and R2represents methyl.

[0362] 31) Another embodiment relates to compounds according to embodiment 1), wherein A represents pyridin-3-yl, wherein said pyridin-3-yl is mono-substituted in eia-position with respect to the point of attachment of said pyridin-3-yl to the rest of the molecule, wherein the substituent is 3-hydroxy-3-(pyrimidin-2-yl)-but-1-yn-1-yl, 3-hydroxy-3-(6-methyl- pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(2-methoxy-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(2-methoxy-6-methyl- pyrimidin-4-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(6-methoxy-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(2,6-dimethoxy- pyrimidin-4-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(2-methyl-pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(6-methoxy-2-methyl- pyrimidin-4-yl)-but-1-yn-1-yl, 3-hydroxy-3-(2,6-dimethyl-pyrimidin-4-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(6-cyclopropyl- pyrimidin-4-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(6-difluoromethyl-pyrimidin-4-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(2- trifluoromethyl-pyrimidin-4-yl)-but-1 -yn-1 -yl, or 3-hydroxy-3-(6-trifluoromethyl-pyrimidin-4-yl)-but-1-yn-1-yl]

[0363] B represents 4-propyl-phenyl, 4-isopropyl-phenyl, 4-isobutyl-phenyl, 4-tert-butyl-phenyl, 3-fluoro-4-isopropyl-phenyl, 3,5-difluoro-4-isopropyl-phenyl, 4-cyclopropyl-phenyl, 4-trifluoromethyl-phenyl, 4-trifluoromethoxy-phenyl, 4-(2,2,2- trifluoro-ethyl)-phenyl, 4-cyclobutyl-phenyl, or 4-(1-trifluoromethyl-cyclopropyl)-phenyl;

[0364] R1represents methyl; and R2represents methyl.

[0365] 32) Another embodiment relates to compounds according to any one of embodiments 1) to 31), which are also compounds of Formula (II) (i.e. the asymmetric carbon atom to which A and B are attached has the absolute configuration depicted in Formula (II)) 33) Another embodiment relates to a compound according to embodiment 1) selected from a group consisting of

[0366] (3-Fluoro-1-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0367] 3-[Hydroxy-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methyl]-1-methyl-azetidine-3-carbonitrile;

[0368] (R)-(1-Ethyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0369] (R)-(3-Methyl-1-propyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0370] (R)-(1-lsopropyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0371] (R)-(1-Cyclopropylmethyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0372] (R)-(1-Cyclobutyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0373] (R)-(1-lsobutyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0374] (R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0375] (R)-[1-(2-Fluoro-ethyl)-3-methyl-azetidin-3-yl]-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0376] (R)-[1-(2,2-Difluoro-ethyl)-3-methyl-azetidin-3-yl]-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0377] (R)-(1-tert-Butyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0378] (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-methoxy-prop-1-ynyl)-pyridin-3-yl]-methanol

[0379] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-prop-1-yn-1-ol;

[0380] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-methyl-but-3-yn-2-ol;

[0381] (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-yn-2-ol;

[0382] (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-yn-2-ol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclopentanol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclopropanol;

[0383] 3-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-azetidine-1- carboxylic acid tert-butyl ester;

[0384] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclobutanol;

[0385] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-yn-1-ol;

[0386] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(1-methyl-1 H-pyrazol-4-ylethynyl)-pyridin-3-yl]-methanol;

[0387] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-phenyl-prop-2-yn-1-ol;

[0388] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-phenyl-but-3-yn-2-ol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-methyl-pent-1-yn-3-ol; 4-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-tetrahydro-pyran-4-ol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(tetrahydro-pyran-4-yl)-prop-

[0389] 2-yn-1-ol;

[0390] 3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 -(1 ,3-dimethyl-1 H-pyrazol-4- yl)-prop-2-yn-1-ol;

[0391] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(tetrahydro-pyran-4-ylethynyl)-pyridin-3-yl]-methanol;

[0392] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(2-methyl-thiazol-4-yl)-prop-

[0393] 2-yn-1-ol;

[0394] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(3-fluoro-phenyl)-but-3-yn-2- ol;

[0395] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(4-methoxy-phenyl)-but-3- yn-2-ol;

[0396] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-phenyl)-but-3- yn-2-ol;

[0397] 4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-pyrazol-3-yl)- but-3-yn-2-ol;

[0398] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-thiazol-4-yl)-but-3- yn-2-ol;

[0399] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyridin-2-yl)-but-

[0400] 3-yn-2-ol;

[0401] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-pyrimidin-2-yl-but-3-yn-2-ol; 4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1 ,5-dimethyl-1 H-pyrazol-3- yl)-but-3-yn-2-ol;

[0402] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyrimidin-4-yl)- but-3-yn-2-ol;

[0403] 3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 -(1 ,5-dimethyl-1 H-pyrazol-3- yl)-prop-2-yn-1-ol;

[0404] 8-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-5,6,7J8-tetrahydro- quinolin-8-ol;

[0405] 7-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-6,7-dihydro-5H-

[0406] [1]pyrindin-7-ol;

[0407] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-pyridin-2-yl-pent-1-yn-3-ol;

[0408] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(6-methoxy-pyridin-2-yl)- pent-1-yn-3-ol; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-azetidin- 1 -y l)-2-methy l-propan- 1 -one;

[0409] (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(1 H-indol-2-ylethynyl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;

[0410] (1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-methoxy-propyl)-pyridin-3-yl]-methanol;

[0411] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-propan-1-ol;

[0412] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-methyl-butan-2-ol;

[0413] (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-butan-2-ol; (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-butan-2-ol; 1-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-cyclopentanol; 1-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-cyclopropanol;

[0414] 3-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-3-hydroxy-azetidine- 1 -carboxylic acid tert-butyl ester;

[0415] 1-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-cyclobutanol;

[0416] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-butan-1-ol;

[0417] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[2-(1-methyl-1 H-pyrazol-4-yl)-ethyl]-pyridin-3-yl}-methanol;

[0418] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-phenyl-propan-1-ol;

[0419] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-phenyl-butan-2-ol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-methyl-pentan-3-ol; 4-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-tetrahydro-pyran-4- ol;

[0420] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(tetrahydro-pyran-4-yl)- propan-1 -ol;

[0421] 3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 -(1 ,3-dimethyl-1 H-pyrazol-4- yl)-propan-1-ol;

[0422] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[2-(tetrahydro-pyran-4-yl)-ethyl]-pyridin-3-yl}-methanol;

[0423] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(2-methyl-thiazol-4-yl)- propan-1 -ol;

[0424] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(3-fluoro-phenyl)-butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(4-methoxy-phenyl)-butan-2- ol;

[0425] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-phenyl)-butan-2- ol;

[0426] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-pyrazol-3-yl)- butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-thiazol-4-yl)- butan-2-ol;

[0427] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyridin-2-yl)- butan-2-ol;

[0428] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-pyrimidin-2-yl-butan-2-ol; 4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1 ,5-dimethyl-1 H-pyrazol-3- yl)-butan-2-ol;

[0429] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyrimidin-4-yl)- butan-2-ol;

[0430] 3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 -(1 ,5-dimethyl-1 H-pyrazol-3- yl)-propan-1-ol;

[0431] 8-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-5,6,7,8-tetrahydro- quinolin-8-ol;

[0432] 7-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-6,7-dihydro-5H-

[0433] [1]pyrindin-7-ol;

[0434] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-pyridin-2-yl-pentan-3-ol;

[0435] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(6-methoxy-pyridin-2-yl)- pentan-3-ol;

[0436] (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[2-(1H-indol-2-yl)-ethyl]-pyridin-3-yl}-(4-isopropyl-phenyl)-methanol; (R)-(4-Cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-{5-[3-(tetrahydro-pyran-4-yl)-[1 ,2,4]oxadiazol-5-yl]-pyridin-3-yl}- methanol;

[0437] (R)-(4-Cyclopropyl-phenyl)-(1 ,3-dimethyl-azetidin-3-yl)-{5-[3-(2-methoxy-1 , 1 -dimethyl-ethyl)-[1 ,2,4]oxadiazol-5-yl]- pyridin-3-yl}-methanol;

[0438] (R)-[5-(3-Cyclobutoxymethyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-(4-cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)- methanol;

[0439] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-propyl-phenyl)-{5-[3-(tetrahydro-pyran-4-yloxymethyl)-[1,2,4]oxadiazol-5-yl]-pyridin-

[0440] 3-yl}-methanol;

[0441] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-propyl-phenyl)-{5-[3-(tetrahydro-pyran-4-yl)-[1 ,2,4]oxadiazol-5-yl]-pyridin-3-yl}- methanol;

[0442] (R)-[5-(3-Cyclobutoxymethyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-propyl-phenyl)- methanol;

[0443] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}- methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-morpholin-4-ylmethyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]- methanol;

[0444] (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[3-(2,6-dimethyl-morpholin-4-ylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-(4- isopropyl-phenyl)-methanol;

[0445] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(4-methyl-tetrahydro-pyran-4-yl)-[1 ,2,4]oxadiazol-5-yl]- pyridin-3-yl}-methanol;

[0446] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[(1S,2S,4R)-3-(7-oxa-bicyclo[2.2.1]hept-2-yl)-[1,2,4]oxadiazol-

[0447] 5-yl]-pyridin-3-yl}-methanol;

[0448] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(tetrahydro-pyran-4-yloxymethyl)-[1 ,2,4]oxadiazol-5-yl]- pyridin-3-yl}-methanol;

[0449] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-morpholin-4-yl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-methanol; (R)-(4-Cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-{5-[3-(4-methoxy-tetrahydro-pyran-4-yl)-[1 ,2,4]oxadiazol-5-yl]- pyridin-3-yl}-methanol;

[0450] (R)-(4-Cyclopropyl-phenyl)-(1 ,3-dimethyl-azetidin-3-yl)-{5-[3-(3-hydroxymethyl-bicyclo[1.1.1]pent-1 -yl)- [1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol;

[0451] (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[3-(3-hydroxymethyl-bicyclo[1.1.1]pent-1-yl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-(4- isopropyl-phenyl)-methanol;

[0452] 2-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)-2- methyl-propan-1-ol;

[0453] 2-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)- propan-2-ol;

[0454] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(1 -methoxy-1 -methyl-ethyl)-[1 ,2,4]oxadiazol-5-yl]-pyridin-3- yl}-methanol;

[0455] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(1-methoxy-cyclobutyl)-[1 ,2,4]oxadiazol-5-yl]-pyridin-3-yl}- methanol;

[0456] 1-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)-2- methyl-propan-2-ol;

[0457] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methanesulfonylmethyl-[1 ,2,4]oxadiazol-3-yl)-pyridin-3-yl]- methanol;

[0458] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(2-methoxy-ethyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;

[0459] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methoxymethyl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]- methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-furan-3-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;

[0460] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-4-yl)-[1 ,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;

[0461] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- cyclohexanol;

[0462] (R)-[5-(5-tert-Butoxymethyl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)- methanol;

[0463] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-4-ylmethyl)-[1,2,4]oxadiazol-3-yl]-pyridin-

[0464] 3-yl}-methanol;

[0465] 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- cyclohexanol;

[0466] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-cyclohexanol;

[0467] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1-methoxy-cyclobutyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;

[0468] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(6-oxa-spiro[2.5]oct-1-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;

[0469] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-3-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;

[0470] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-(tetrahydro-furan-2-yl)methyl]-[1,2,4]oxadiazol-3-yl}- pyridin-3-yl)-methanol;

[0471] (R)-2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- 1,1,1 -trifluoro-propan-2-ol;

[0472] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1 -methoxy-1 -methyl-ethyl)-[1 ,2,4]oxadiazol-3-yl]-pyridin-3- yl}-methanol;

[0473] (R)-{5-[5-((R)-Cyclohexyl-hydroxy-methyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl- phenyl)-methanol;

[0474] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- cyclopropanol;

[0475] 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;

[0476] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- cyclopentanol; 3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-5-yl)- cyclobutanol;

[0477] (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[5-(4-fluoro-tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(4-isopropyl- phenyl)-methanol;

[0478] (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[5-((2R,4R,6S)-2,6-dimethyl-tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3- yl}-(4-isopropyl-phenyl)-methanol;

[0479] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-4-yloxymethyl)-[1 ,2,4]oxadiazol-3-yl]- pyridin-3-yl}-methanol;

[0480] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-methyl-1-(tetrahydro-pyran-4-yl)-ethyl]-[1 ,2,4]oxadiazol- 3-yl}-pyndin-3-yl)-methanol;

[0481] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[2-(tetrahydro-pyran-4-yl)-ethyl]-[1 ,2,4]oxadiazol-3-yl}- pyridin-3-yl)-methanol;

[0482] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- cyclobutanol;

[0483] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-2- methyl-propan-2-ol;

[0484] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(7-oxa-bicyclo[2.2.1]hept-2-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-

[0485] 3-yl}-methanol;

[0486] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(4-methyl-tetrahydro-pyran-4-yloxymethyl)-[1,2,4]oxadiazol- 3-yl]-pyridin-3-yl}-methanol;

[0487] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-oxetan-3-yl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-methanol; (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(2-methoxy-1 , 1 -dimethyl-ethyl)-[1 ,2,4]oxadiazol-3-yl]- pyridin-3-yl}-methanol;

[0488] 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-2- methyl-propan-1-ol;

[0489] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(2-methoxy-2-methyl-propyl)-[1,2,4]oxadiazol-3-yl]-pyridin-

[0490] 3-yl}-methanol;

[0491] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-cyclobutanol;

[0492] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1-methoxymethyl-cyclopropylmethyl)-[1 ,2,4]oxadiazol-3-yl]- pyridin-3-yl}-methanol;

[0493] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(2-pyrazol-1-yl-ethyl)-[1 ,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol; (R)-N-(2-(3-(5-((1 ,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5- yl)ethyl)acetamide-2,2,2-d3;

[0494] (R)-N-(1-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)-2- methylpropan-2-yl)acetamide-2,2,2- / ¾

[0495] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1-yl]-2-hydroxy-ethanone;

[0496] (R)-1-(4-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5- yl)piperidin-1-yl)ethan-1-one-2,2,2-d3;

[0497] N-[2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- ethyl]-2-hydroxy-N-methyl-acetamide;

[0498] (R)-N-(2-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)ethyl)- N-methylacetamide-d3;

[0499] (1 ,3-Dimethyl-azetidin-3-yl)-(6-methoxy-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0500] (1 ,3-Dimethyl-azetidin-3-yl)-(6-phenoxy-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0501] (1 ,3-Dimethyl-azetidin-3-yl)-(6-ethoxy-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0502] (1 ,3-Dimethyl-azetidin-3-yl)-(5-methyl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0503] (1 ,3-Dimethyl-azetidin-3-yl)-(4-propyl-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;

[0504] (1 ,3-Dimethyl-azetidin-3-yl)-(4-methoxy-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;

[0505] (1 ,3-Dimethyl-azetidin-3-yl)-phenyl-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;

[0506] (4-Cyclobutyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;

[0507] (4-Cyclobutoxy-phenyl)-(1,3-dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;

[0508] (1 ,3-Dimethyl-azetidin-3-yl)-(4-ethoxy-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;

[0509] (4-tert-Butyl-phenyl)-(1 ,3-dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;

[0510] (1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropoxy-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;

[0511] (1 ,3-Dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methanol;

[0512] (1 ,3-Dimethyl-azetidin-3-yl)-[4-(1-methyl-cyclopropyl)-phenyl]-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (4-Cyclopropoxy-phenyl)-(1,3-dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;

[0513] (S)-[2-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-4-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (S)-[2-((3R,4S)-3,4-Difluoro-pyrrolidin-1-yl)-pyridin-4-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (S)-(1,3-Dimethyl-azetidin-3-yl)-(2-isobutoxy-pyridin-4-yl)-(4-isopropyl-phenyl)-methanol; 4-{4-[(S)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-2-yl}-2-methyl-butan-2-ol; (R)-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridazin-4-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (S)-5-tert-Butyl-3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-oxazolidin-2- one;

[0514] (R)-1-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-3-ol;

[0515] (S)-1-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-3-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((S)-3-hydroxymethyl-pyrrolidin-1-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;

[0516] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;

[0517] (S)-1-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-methyl-pyrrolidin-3-ol; 3-Cyclopropyl-1-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-3-ol; 2-((S)-1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-3-yl)-propan- 2-ol;

[0518] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-morpholin-4-yl-pyridin-3-yl)-methanol;

[0519] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-5'-yl)-methanol;

[0520] (R)-[5-(7-Aza-bicyclo[2.2.1]hept-7-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0521] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-((S)-2-methyl-pyrrolidin-1-yl)-pyridin-3-yl]-methanol;

[0522] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-trifluoromethyl-pyrrolidin-3- ol;

[0523] (R)-[5-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0524] 5'-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-4-ol;

[0525] 5'-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-3-ol:

[0526] (R)-{5-[(2-Benzyloxy-ethyl)-methyl-amino]-pyridin-3-yl}-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0527] (R)-(1,3-Dimethyl-azetidin-3-yl)-[4-(1-methyl-cyclopropyl)-phenyl]-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;

[0528] (R)-[5-((3R,4S)-3,4-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-[4-(1-trifluoromethyl-cyclopropyl)- phenylj-methanol;

[0529] 2-[(S)-1-(5-{(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)- pyrrolidin-3-yl]-propan-2-ol;

[0530] (R)-(1,3-Dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methanol;

[0531] (R)-(4-tert-Butyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-(3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-5'-yl)-methanol;

[0532] (R)-(1,3-Dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0533] (R)-{5-[5-(1-Cyclopropanesulfonyl-piperidin-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(1,3-dimethyl-azetidin-3-yl)-(4- isopropyl-phenyl)-methanol;

[0534] 2-({5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-methyl-amino)-ethanol; (R)-1-((S)-1-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-3-yl)- ethanol;

[0535] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-oxazolidin-2-one; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-5-phenyl-oxazolidin-2-one;

[0536] 5-Benzyl-3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-oxazolidin-2-one; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-5-isopropyl-oxazolidin-2-one;

[0537] 6-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-oxa-6-aza-spiro[2.4]heptan- 5-one;

[0538] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-oxa-3-aza-spiro[4.4]nonan-

[0539] 2-one;

[0540] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-5-(tetrahydro-pyran-4-yl)- oxazolidin-2-one;

[0541] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-5,5-dimethyl-oxazolidin-2-one;

[0542] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-8,8-difluoro-1-oxa-3-aza- spiro[4.5]decan-2-one;

[0543] 9-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-7-oxa-9-aza- dispiro[3.1.4.1]undecan-8-one;

[0544] 2-Cyclopropyl-7-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-5-oxa-7-aza- spiro[3.4]octan-6-one;

[0545] 7-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2,2-dimethyl-5-oxa-7-aza- spiro[3.4]octan-6-one;

[0546] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-phenyl-pyrrolidin-2-one;

[0547] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-2-one;

[0548] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-isopropyl-pyrrolidin-2-one;

[0549] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-isopropyl-pyrrolidin-2-one;

[0550] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4,4-dimethyl-pyrrolidin-2-one;

[0551] 5-(5-((R)-(1,3-Dimethyl-azetidin-3-yl)(hydroxy)(4-isopropyl-phenyl)methyl)pyridin-3-yl)hexahydro-4H-furo[2,3-c]pyrrol-

[0552] 4-one;

[0553] 2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-aza-spiro[4.4]nonan-3-one;

[0554] 6-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-6-aza-spiro[3.4]octan-5-one;

[0555] 2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-8-oxa-2-aza-spiro[4.5]decan-

[0556] 3-one;

[0557] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(tetrahydro-pyran-4-yl)- pyrrolidin-2-one;

[0558] 2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-aza-spiro[4.5]decan-1-one; 2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-8-oxa-2-aza-spiro[4.5]decan- 1-one; (S)-1-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-isobutyl-pyrrolidin-2-one; 4-Cyclopropyl-1-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-trifluoromethyl-pyrrolidin-2- one;

[0559] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(2-methoxy-ethyl)-pyrrolidin-

[0560] 2-one;

[0561] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(2-methoxy-ethyl)-pyrrolidin-

[0562] 2-one;

[0563] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-pyrrolidin-2-one;

[0564] (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-((R)-3-isopropyl-pyrrolidin-1-yl)-pyridin-3-yl]-methanol;

[0565] (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((2R,6S)-2,6-dimethyl-morpholin-4-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;

[0566] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(6-oxa-3-aza-bicyclo[3.1.1]hept-3-yl)-pyridin-3-yl]-methanol;

[0567] (R)-[5-((3R,4S)-3,4-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0568] (R)-[5-((3S,4S)-3,4-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0569] (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((2S,6S)-2,6-dimethyl-morpholin-4-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;

[0570] (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((2R,6R)-2,6-dimethyl-morpholin-4-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;

[0571] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyrrolidin-1-yl]-pyridin-3-yl}- methanol;

[0572] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(4-methyl-thiazol-2-yl)-pyrrolidin-1-yl]-pyridin-3-yl}- methanol;

[0573] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-phenyl-pyrrolidin-1-yl)-pyridin-3-yl]-methanol;

[0574] (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(3,3-dimethyl-pyrrolidin-1-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;

[0575] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[(1S,4S)-5-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-pyridin-3-yl]- methanol;

[0576] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(2,2,6,6-tetrafluoro-morpholin-4-yl)-pyridin-3-yl]-methanol;

[0577] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-((R)-2-methoxymethyl-morpholin-4-yl)-pyridin-3-yl]-methanol;

[0578] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-((S)-2-methoxymethyl-morpholin-4-yl)-pyridin-3-yl]-methanol;

[0579] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-trifluoromethyl-pyrrolidin-1-yl)-pyridin-3-yl]-methanol;

[0580] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[(1 R,4R)-5-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-pyridin-3-yl]- methanol;

[0581] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[(1S,5R)-5-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-pyridin-3-yl]- methanol;

[0582] (R)-(1,3-Dimethyl-azetidin-3-yl)-[(1S,4S)-5-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-pyridin-3-yl]-[4-(1-trifluoromethyl- cyclopropyl)-phenyl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-[5-(6-oxa-3-aza-bicyclo[3.1.1]hept-3-yl)-pyridin-3-yl]-methanol; (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-[(1 S,4S)-5-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-pyridin-3-yl]- methanol;

[0583] (R)-(5-Benzyloxy-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0584] (1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(2-pyridin-2-yl-ethoxy)-pyridin-3-yl]-methanol;

[0585] (1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(2-methoxy-ethoxy)-pyridin-3-yl]-methanol;

[0586] (1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(oxetan-3-ylmethoxy)-pyridin-3-yl]-methanol;

[0587] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-propan-1-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(5-isopropoxy-pyridin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(5-Cyclohexyloxy-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0588] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-2-methyl-propan-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-methoxy-cyclopentyloxy)-pyridin-3-yl]-methanol; (R)-[5-(3-Cyclopropyl-[1,2,4]oxadiazol-5-ylmethoxy)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)- methanol;

[0589] (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[2-(3,5-dimethyl-[1,2,4]triazol-1-yl)-ethoxy]-pyridin-3-yl}-(4-isopropyl-phenyl)- methanol;

[0590] 4-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-2-methyl-butan-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-methoxy-pyridin-3-yl)-methanol; (R)-[5-(2-Benzyloxy-ethoxy)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(tetrahydro-pyran-4-yloxy)-pyridin-3-yl]-methanol;

[0591] 2-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-ethanol; 4-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-cyclohexanol;

[0592] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-1-methyl-cyclohexanol; (1,3-Dimethyl-azetidin-3-yl)-(2-phenoxy-pyrimidin-5-yl)-(4-trifluoromethoxy-phenyl)-methanol; (6-Benzyloxy-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(5-pyrazol-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(6-fluoro-5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;

[0593] 5-[(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-3-pyrrolidin-1-yl-pyridine-2-carbonitrile; (1,3-Dimethyl-azetidin-3-yl)-[6-(tetrahydro-pyran-4-yloxy)-pyridin-3-yl]-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-[6-(oxetan-3-ylmethoxy)-pyridin-3-yl]-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(4-methyl-thiazol-2-yl)-pyridin-3-yl]-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methyl-thiazol-2-yl)-pyridin-3-yl]-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(2-methoxy-pyrimidin-5-yl)-methanol; (S)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(2-pyrrolidin-1-yl-pyridin-4-yl)-methanol;

[0594] (1 ,3-Dimethyl-azetidin-3-yl)-[2-((R)-2-hydroxymethyl-pyrrolidin-1-yl)-pyridin-4-yl]-(4-isopropyl-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4'-yl)-methanol;

[0595] (1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(2-morpholin-4-yl-pyridin-4-yl)-methanol; (S)-(1,3-Dimethyl-azetidin-3-yl)-(2-ethyl-pyridin-4-yl)-(4-isopropyl-phenyl)-methanol;

[0596] (S)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[2-(tetrahydro-pyran-4-ylmethoxy)-pyridin-4-yl]-methanol;

[0597] (S)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[2-(2-methoxy-ethoxy)-pyridin-4-yl]-methanol;

[0598] (S)-(2-Cyclopentyl-pyridin-4-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0599] (R)-(1,3-Dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethyl-phenyl)-methanol;

[0600] (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((R)-3-hydroxymethyl-3-methyl-pyrrolidin-1-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)- methanol;

[0601] (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((S)-3-fluoro-pyrrolidin-1-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;

[0602] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[4-(tetrahydro-pyran-4-yl)-[1,2,3]triazol-1-yl]-pyridin-3-yl}- methanol;

[0603] (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-methyl-pyridin-3-yl)-methanol;

[0604] (1,3-Dimethyl-azetidin-3-yl)-(5-isopropenyl-pyridin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0605] (5-Cyclopropyl-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0606] (5-Cyclopent-1-enyl-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0607] 3-{5-[(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-cyclopent-2-enol;

[0608] (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-isopropyl-pyridin-3-yl)-methanol;

[0609] (5-Cyclopentyl-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0610] 3-{5-[(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-cyclopentanol;

[0611] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-pyridin-3-yl-methanol;

[0612] 3-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-cyclopent-2-enone;

[0613] 3-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-methyl-cyclopent-2-enol;

[0614] (3S)-3-(5-((R)-(1, 3-dimethyl azetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1-methylcyclopentan-1-ol;

[0615] (3R)-3-(5-((R)-(1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1-methylcyclopentan-1-ol;

[0616] 3-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-ethyl-cyclopentanol;

[0617] 3-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-isopropyl-cyclopentanol;

[0618] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(4-methyl-oxazol-2-yl)-pyridin-3-yl]-methanol;

[0619] (R)-(1,3-Dimethyl-azetidin-3-yl)-(5-ethyl-pyridin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0620] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-methyl-pyridin-3-yl)-methanol;

[0621] (R)-[5-(4,5-Dihydro-furan-3-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0622] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(tetrahydro-furan-3-yl)-pyridin-3-yl]-methanol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-en-1-ol; N-Cyclopentyl-5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-nicotinamide;

[0623] {5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-1-yl-methanone; 5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-N-(tetrahydro-pyran-4-yl)-nicotinamide;

[0624] (1 ,3-Dimethyl-azetidin-3-yl)-[4-(3-methoxy-propyl)-phenyl]-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;

[0625] (R)-(4-Cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;

[0626] (R)-(1,3-Dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-p-tolyl-methanol;

[0627] 5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'- carboxylic acid tert-butyl ester;

[0628] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester;

[0629] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(tetrahydro-pyran-4-yl)-pyridin-3-yl]-methanol;

[0630] (R)-(1l3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(3'l4'l5'l6'-tetrahydro-2'H-[2l1';4'l3"]terpyridin-5"-yl)-methanol;

[0631] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(1'-phenyl-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-5-yl)- methanol;

[0632] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[1'-(toluene-4-sulfonyl)-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-

[0633] 5-yl]-methanol;

[0634] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(tetrahydro-furan-2-yl)-pyridin-3-yl]-methanol;

[0635] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methyl-tetrahydro-furan-2-yl)-pyridin-3-yl]-methanol;

[0636] (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(5,5-dimethyl-tetrahydro-furan-2-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;

[0637] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2,2-difluoro-propan-1-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methyl-oxazol-2-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-4-yl)-oxazol-2-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(4-fluoro-phenoxymethyl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol; Isopropyl-carbamic acid 5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylmethyl ester;

[0638] (R)-[5-(2-Benzyloxy-ethyl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0639] 4-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-methyl-cyclohexanol; 2-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-cyclopropyl)-propan-2-ol;

[0640] (S)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{2-[5-(tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-4-yl}- methanol;

[0641] (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(2-pyrrolidin-1-yl-pyrimidin-5-yl)-methanol; and (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(6-pyrrolidin-1-yl-pyrazin-2-yl)-methanol.

[0642] 34) Another embodiment relates to a compound according to embodiment 1) selected from a group consisting of (R)-N-(1-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5- yl)cyclopropyl)acetamide-2,2,2-d3;

[0643] (R)-N-(1-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5- yl)cyclopropyl)-N-methylacetamide-d3;

[0644] (R)-N-((3-(5-((1, 3-dimethyl azetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1, 2, 4-oxadiazol-5-yl)methyl)- N-methylacetamide-d3;

[0645] N-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-2-hydroxy-acetamide;

[0646] (R)-N-((3-(5-((1, 3-dimethyl azetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1, 2, 4-oxadiazol-5- yl)methyl)acetamide-2,2,2-d3;

[0647] 1-(3-{5-[(R)-Hydroxy-(1-isopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-2-methyl-propan-2-ol;

[0648] 1-(3-{5-[(R)-(1-Ethyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-2- methyl-propan-2-ol;

[0649] 2-(3-{5-[(R)-Hydroxy-(1-isopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-propan-2-ol;

[0650] 2-(3-{5-[(R)-(1-Ethyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;

[0651] 4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)- piperidine-1 -carboxylic acid benzyl ester;

[0652] 1-[4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)- piperidin-1 -yl]-ethanone;

[0653] (R)-1-(3-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5- yl)azetidin-1-yl)ethan-1-one-2,2,2-d3;

[0654] (R)-1-(3-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)-3- methylazetidin-1-yl)ethan-1-one-2,2,2-d3;

[0655] (R)-1-(3-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)-3- fluoroazetidin-1 -yl)ethan-1 -one-2,2,2-d3;

[0656] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1 -methyl-1 -morpholin-4-yl-ethyl)-[1, 2, 4]oxadiazol-3-yl]- pyridin-3-yl}-methanol;

[0657] 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- methyl-piperidin-2-one;

[0658] 1-[(S)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-pyrrolidin-1-yl]-ethanone; 1-[(R)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-pyrrolidin-1-yl]-ethanone;

[0659] N-[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- methyl-ethyl]-acetamide;

[0660] 1-Benzyl-3-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-pyrrolidin-2-one;

[0661] 3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1,3- dimethyl-pyrrolidin-2-one;

[0662] 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- isobutyl-pyrrolidin-2-one;

[0663] 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- furan-2-ylmethyl-pyrrolidin-2-one;

[0664] 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- phenyl-pyrrolidin-2-one;

[0665] 1-Benzyl-4-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-pyrrolidin-2-one;

[0666] 5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- phenyl-pyrrolidin-2-one;

[0667] 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- pyrrolidin-2-one;

[0668] (S)-5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- pyrrolidin-2-one;

[0669] (R)-5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- pyrrolidin-2-one;

[0670] (S)-6-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-2-one;

[0671] 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-2-one;

[0672] (S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- azetidin-2-one;

[0673] (S)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- azetidin-2-one;

[0674] (S)-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1,4- dimethyl-pyrrolidin-2-one; (R)-4-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-5-yl)- 1 ,4-dimethyl-pyrrolidin-2-one;

[0675] (R) or (S)-4-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol- 5-yl)-1,4-dimethyl-pyrrolidin-2-one;

[0676] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-piperidin-4-yl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-methanol; (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(4-methyl-piperidin-4-yl)-[1 ,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;

[0677] (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[5-(4-fluoro-piperidin-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(4-isopropyl-phenyl)- methanol;

[0678] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-butan-1 -one;

[0679] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-2,2-dimethyl-propan-1 -one;

[0680] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1-yl]-2-methoxy-ethanone;

[0681] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1-yl]-3-methoxy-propan-1-one;

[0682] Cyclopropyl-[4-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-

[0683] [1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone;

[0684] Cyclopentyl-[4-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-

[0685] [1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone;

[0686] [4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-5-yl)- piperidin-1-yl]-(tetrahydro-pyran-4-yl)-methanone;

[0687] [4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1-yl]-phenyl-methanone;

[0688] 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidine-1 -carboxylic acid methyl ester;

[0689] 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidine-1 -carboxylic acid ethyl ester;

[0690] 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidine-1 -carboxylic acid 2-methoxy-ethyl ester;

[0691] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1-methanesulfonyl-piperidin-4-yl)-[1,2,4]oxadiazol-3-yl]- pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-(propane-2-sulfonyl)-piperidin-4-yl]-[1,2,4]oxadiazol-3-yl}- pyridin-3-yl)-methanol;

[0692] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-(propane-1-sulfonyl)-piperidin-4-yl]-[1 ,2,4]oxadiazol-3-yl}- pyridin-3-yl)-methanol;

[0693] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-(2-methoxy-ethanesulfonyl)-piperidin-4-yl]-

[0694] [1,2,4]oxadiazol-3-yl}-pyridin-3-yl)-methanol;

[0695] 2-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidine-1 -sulfonyl]-ethanol;

[0696] (R)-{5-[5-(1-Cyclopentanesulfonyl-piperidin-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(1,3-dimethyl-azetidin-3-yl)-(4- isopropyl-phenyl)-methanol;

[0697] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-(tetrahydro-pyran-4-sulfonyl)-piperidin-4-yl]-

[0698] [1,2,4]oxadiazol-3-yl}-pyridin-3-yl)-methanol;

[0699] 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidine-1 -sulfonic acid methylamide;

[0700] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1-methylamino-cyclopropyl)-[1,2,4]oxadiazol-3-yl]-pyridin-

[0701] 3-yl}-methanol;

[0702] [1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- cyclopropyl]-methyl-carbamic acid ethyl ester;

[0703] N-[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- cyclopropyl]-N-methyl-methanesulfonamide;

[0704] (R)-(1,3-Dimethyl-azetidin-3-yl)-[6-(2,2-dimethyl-cyclopentyloxy)-pyridazin-4-yl]-(4-isopropyl-phenyl)-methanol;

[0705] (R)-[6-(3,3-Difluoro-cyclopentyloxy)-pyridazin-4-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;

[0706] 2-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yloxy}-phenyl)-ethanol;

[0707] 2-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yloxy}-phenyl)-ethanol;

[0708] (R)-[6-(Chroman-6-yloxy)-pyridazin-4-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; 6-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yloxy}-3H-benzooxazol-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(6-methyl-pyrimidin-4-yl)- pent-1-yn-3-ol;

[0709] (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyrimidin-4- yl)-but-3-yn-2-ol;

[0710] (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyrimidin-4- yl)-but-3-yn-2-ol;

[0711] (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1,5-dimethyl-1H- pyrazol-3-yl)-but-3-yn-2-ol; (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1,5-dimethyl-1H- pyrazol-3-yl)-but-3-yn-2-ol;

[0712] (R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1 ,5-dimethyl-1 H- pyrazol-3-yl)-but-3-yn-2-ol;

[0713] (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1,5-dimethyl-1H- pyrazol-3-yl)-but-3-yn-2-ol;

[0714] (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[1-(4-fluoro-phenyl)-cyclopropylethynyl]-pyridin-3-yl}-(4-isopropyl-phenyl)-methanol;

[0715] (S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-pyrazol-3- yl)-but-3-yn-2-ol;

[0716] (R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-pyrazol-3- yl)-but-3-yn-2-ol;

[0717] (R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-pyrazol-3- yl)-but-3-yn-2-ol;

[0718] (S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-pyrazol-3- yl)-but-3-yn-2-ol;

[0719] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-pyrrolidine-

[0720] 1 -carboxylic acid tert-butyl ester;

[0721] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-piperidine-1-carboxylic acid tert-butyl ester;

[0722] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(6-methyl-pyrimidin-4-yl)- pentan-3-ol;

[0723] 2-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-benzoic acid methyl ester;

[0724] (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[2-(2-hydroxymethyl-phenyl)-ethyl]-pyridin-3-yl}-(4-isopropyl-phenyl)-methanol;

[0725] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyrimidin-4-yl)- butan-2-ol;

[0726] 3-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-3-hydroxy- pyrrolidine-1 -carboxylic acid tert-butyl ester;

[0727] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[2-(1H-pyrrolo[2,3-b]pyridin-2-yl)-ethyl]-pyridin-3-yl}-methanol;

[0728] 4-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-piperidine-1- carboxylic acid tert-butyl ester;

[0729] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-pyridin-2-yl-butan-2-ol; 1-Cyclopropyl-3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-pyridin-2-yl- propan-1 -ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(5-methyl-pyridin-3-yl)- butan-2-ol;

[0730] 8-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-ethyl)-5,6,7,8-tetrahydro- quinolin-8-ol;

[0731] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-2-(6-methoxy-pyridin-2-yl)- butan-2-ol;

[0732] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-2-(6-methyl-pyridin-2-yl)- butan-2-ol;

[0733] (1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(6-pyrrolidin-1-yl-pyridin-2-yl)-methanol;

[0734] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- fluoro-piperidin-1-yl]-ethanone;

[0735] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- methyl-piperidin-1-yl]-ethanone;

[0736] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-cyclohexanone; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-cyclohexanol; (R)-(5-Cyclopentyloxymethyl-pyridin-3-yl)-(1 ,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; 1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylmethoxy}-piperidin-1-yl)- ethanone;

[0737] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[6-(tetrahydro-pyran-4-yl)-pyridazin-4-yl]-methanol;

[0738] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-2-phenyl-butan-2-ol;

[0739] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{6-[(S)-(tetrahydro-furan-3-yl)oxy]-pyridazin-4-yl}-methanol;

[0740] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{6-[(R)-(tetrahydro-furan-3-yl)oxy]-pyridazin-4-yl}-methanol;

[0741] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4-methyl-pyrrolidin-2-one;

[0742] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-3-isopropyl-pyrrolidin-2-one;

[0743] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-3,3-dimethyl-pyrrolidin-2- one;

[0744] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4,4-dimethyl-pyrrolidin-2- one;

[0745] 5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-5-aza-spiro[2.4]heptan-6- one;

[0746] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4-trifluoromethyl-pyrrolidin-

[0747] 2-one;

[0748] 4-Cyclopropyl-1-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-pyrrolidin-2- one; 2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-8-oxa-2-aza- spiro[4.5]decan-3-one;

[0749] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-1-oxa-3-aza- spiro[4.5]decan-2-one;

[0750] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4-pyridin-2-yl-pyrrolidin-2- one;

[0751] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-3-(2-methoxy-ethyl)- pyrrolidin-2-one;

[0752] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4-phenyl-pyrrolidin-2-one;

[0753] 2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-2,3-dihydro-isoindol-1-one; 2-(3-{5-[(S)-(3-Fluoro-1-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;

[0754] 2-(3-{5-[(S)-(1-Cyclopropyl-3-fluoro-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-

[0755] 5-yl)-propan-2-ol;

[0756] 1-[4-(3-{5-[(S)-(3-Fluoro-1-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-piperidin-1 -yl]-ethanone;

[0757] 1-[4-(3-{5-[(S)-(1-Cyclopropyl-3-fluoro-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-

[0758] [1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone;

[0759] 2-(3-{5-[(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol- 5-yl)-propan-2-ol;

[0760] 1-[4-(3-{5-[(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-

[0761] [1.2.4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone;

[0762] (R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-4-yl)-[1 ,2,4]oxadiazol-3-yl]- pyridin-3-yl}-methanol; trans-4-(3-{5-[(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-

[0763] [1.2.4]oxadi azol-5-y l)-cyclohexanol ;

[0764] (R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-oxetan-3-yl-[1 ,2,4]oxadiazol-3-yl)-pyridin-3-yl]- methanol;

[0765] 1-[(R)-3-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-5- ylmethyl)-pyrrolidin-1-yl]-ethanone;

[0766] 1-[3-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone;

[0767] 1-[3-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-3- hydroxy-piperidin-1-yl]-ethanone; 1-[3-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-3- methyl-piperidin-1-yl]-ethanone;

[0768] 1-[3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-piperidin-1-yl]-ethanone;

[0769] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-4-hydroxy-piperidin-1-yl]-ethanone;

[0770] N-[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-cyclopropyl]-acetamide;

[0771] Tetrahydro-pyran-4-carboxylic acid [1-(3-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]- pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-cyclopropyl]-amide;

[0772] N-[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-cyclopropyl]-2-methoxy-acetamide;

[0773] N-[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-cyclopropyl]-N-methyl-acetamide;

[0774] N-[2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-

[0775] 1 , 1 -dimethyl-ethyl]-propionamide;

[0776] N-[2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-

[0777] 1 , 1 -dimethyl-ethyl]-2-methoxy-acetamide;

[0778] Tetrahydro-pyran-4-carboxylic acid [2-(3-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]- pyridin-3-yl}-[1 ,2,4]oxadiazol-5-yl)-1 , 1 -dimethyl-ethyl]-amide;

[0779] N-[2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-

[0780] 1 , 1 -dimethyl-ethyl]-isobutyramide;

[0781] Cyclopropanecarboxylic acid [2-(3-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3- yl}-[1,2,4]oxadiazol-5-yl)-1,1-dimethyl-ethyl]-amide;

[0782] 1-[cis-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)

[0783] -2-methyl-piperidin-1-yl]-ethanone;

[0784] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- hydroxy-piperidin-1-yl]-2-methyl-propan-1-one;

[0785] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- hydroxy-piperidin-1 -yl]-propan-1 -one;

[0786] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- methoxy-piperidin-1-yl]-ethanone;

[0787] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1-yl]-3,3,3-trifluoro-propan-1-one; 1-[4-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1-yl]-2-oxetan-3-yl-ethanone;

[0788] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- ethyl-piperidin-1 -yl]-ethanone;

[0789] [4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-5-yl)- piperidin-1-yl]-oxetan-3-yl-methanone;

[0790] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- isopropyl-piperidin-1-yl]-2-methoxy-ethanone;

[0791] 1-[cis-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-

[0792] 3-methyl-piperidin-1-yl]-ethanone;

[0793] 5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- methyl-piperidin-2-one;

[0794] 5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-5- methyl-piperidin-2-one;

[0795] 5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-2-one;

[0796] 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- methyl-pyrrolidin-2-one;

[0797] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-3,3-dimethyl-pyrrolidine-2,5-dione;

[0798] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-imidazolidine-2,4-dione;

[0799] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-pyrrolidin-2-one;

[0800] 3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-imidazolidine-2,4-dione;

[0801] 3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-1-methyl-imidazolidine-2,4-dione;

[0802] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-3-methyl-imidazolidine-2,4-dione;

[0803] 3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-oxazolidin-2-one;

[0804] 1-Cyclopropyl-3-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-

[0805] [1,2,4]oxadiazol-5-ylmethyl)-imidazolidin-2-one; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-pyrrolidine-2,5-dione;

[0806] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-3-methyl-imidazolidin-2-one;

[0807] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-imidazolidin-2-one;

[0808] 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propane-1 ,2-diol;

[0809] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-pyridin-3-yl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-methanol;

[0810] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-piperidin-1-yl]-ethanone;

[0811] (3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- acetonitrile;

[0812] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- hydroxy-piperidin-1-yl]-ethanone;

[0813] 3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propionitrile;

[0814] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-3- methoxy-piperidin-1-yl]-ethanone;

[0815] 1-[(R)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-piperidin-1 -yl]-ethanone;

[0816] 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- tetrahydro-pyran-4-ol;

[0817] (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[5-(3-hydroxymethyl-bicyclo[1.1.1]pent-1-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(4- isopropyl-phenyl)-methanol;

[0818] 4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- methyl-piperidine-2, 6-dione;

[0819] 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-2,2- difluoro-ethanol;

[0820] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(3-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;

[0821] (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(5-isopropyl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;

[0822] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(6-methyl-pyrimidin-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol; (R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- methyl-pyrrolidin-2-one;

[0823] (S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- methyl-pyrrolidin-2-one;

[0824] (S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- ethyl-pyrrolidin-2-one;

[0825] (R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- ethyl-pyrrolidin-2-one;

[0826] (R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- ethyl-pyrrolidin-2-one;

[0827] (S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- ethyl-pyrrolidin-2-one;

[0828] (S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- isopropyl-pyrrolidin-2-one;

[0829] (R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- isopropyl-pyrrolidin-2-one;

[0830] (R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- isopropyl-pyrrolidin-2-one;

[0831] (S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- isopropyl-pyrrolidin-2-one;

[0832] 1-[(S)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-pyrrolidin-1-yl]-ethanone;

[0833] (S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-2-one;

[0834] (R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-2-one;

[0835] (R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-2-one;

[0836] (S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-2-one;

[0837] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methyl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-methanol;

[0838] (R)-{5-[5-(1,1-Difluoro-ethyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)- methanol; 4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-3-yl)- tetrahydro-pyran-4-ol;

[0839] (R)-[5-(3-tert-Butoxymethyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)- methanol;

[0840] (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(3-hydroxymethyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol; 1-[4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)- piperazin-1 -yl]-ethanone;

[0841] 1-[3-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3- ylmethyl)-azetidin-1-yl]-ethanone;

[0842] 4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3- ylmethyl)-tetrahydro-pyran-4-ol;

[0843] [4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-3-yl)- piperidin-1-yl]-[1,4]dioxan-2-yl-methanone;

[0844] 1-[4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)- piperidin-1-yl]-2-methoxy-ethanone;

[0845] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(1-methanesulfonyl-piperidin-4-yl)-[1 ,2,4]oxadiazol-5-yl]- pyridin-3-yl}-methanol;

[0846] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{3-[1-(2-methoxy-ethanesulfonyl)-piperidin-4-yl]-

[0847] [1.2.4]oxadiazol-5-yl}-pyridin-3-yl)-methanol;

[0848] 1-[4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)- piperidin-1-yl]-2-hydroxy-ethanone;

[0849] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-[1,2,4]oxadiazol-3-yl-pyridin-3-yl)-methanol;

[0850] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone;

[0851] 2-(3-{5-[(R)-(4-Bromo-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan- 2-ol;

[0852] 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-naphthalen-2-yl-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2- ol;

[0853] 2-[3-(5-{(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-

[0854] [1.2.4]oxadiazol-5-yl]-propan-2-ol;

[0855] 2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-phenyl]-methyl}-pyridin-3-yl)-

[0856] [1,2,4]oxadiazol-5-yl]-propan-2-ol;

[0857] 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropoxy-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol; 2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-methyl}-pyridin-

[0858] 3-yl)-[1,2,4]oxadiazol-5-yl]-propan-2-ol;

[0859] (R)-2-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-(pentafluoro- 6-sulfaneyl)phenyl) methyl)pyridin-3-yl)-1 ,2,4- oxadiazol-5-yl)propan-2-ol;

[0860] 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-(3-fluoro-4-isopropyl-phenyl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-propan-2-ol;

[0861] 2-(3-{5-[(R)-(4-tert-Butyl-phenyl)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-5-yl)- propan-2-ol;

[0862] 2-(3-{5-[(R)-Benzo[b]thiophen-5-yl-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;

[0863] 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-pentafluoroethyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-propan-2-ol;

[0864] 2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-methyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-

[0865] [1,2,4]oxadiazol-5-yl]-propan-2-ol;

[0866] 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-3-methyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-

[0867] 5-yl)-propan-2-ol;

[0868] 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-propan-2-ol;

[0869] 1-[4-(3-{5-[(R)-(4-Bromo-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone;

[0870] 2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-[4-(1-fluoro-1-methyl-ethyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-

[0871] [1.2.4]oxadiazol-5-yl]-propan-2-ol;

[0872] 2-(3-{5-[(R)-[4-(1,1-Difluoro-ethyl)-phenyl]-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-propan-2-ol;

[0873] 2-(3-{5-[(R)-(4-Bicyclo[1.1.1]pent-1-yl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-

[0874] [1.2.4]oxadiazol-5-yl)-propan-2-ol;

[0875] (R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[5-(tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-[4-(2,2,2-trifluoro- ethyl)-phenyl]-methanol;

[0876] 2-[3-(5-{(R)-(1 ,3-Dimethyl-azetidin-3-yl)-[4-(1 , 1 -dimethyl-propyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-

[0877] [1.2.4]oxadiazol-5-yl]-propan-2-ol;

[0878] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-(3-fluoro-4-isopropyl-phenyl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-

[0879] 5-yl)-piperidin-1-yl]-ethanone;

[0880] 1-{4-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-

[0881] [1.2.4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone; 1-[4-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol- 5-yl)-piperidin-1-yl]-ethanone;

[0882] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropoxy-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone;

[0883] 2-(3-{5-[(R)-(3-Chloro-4-isopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-propan-2-ol;

[0884] 2-(3-{5-[(R)-(4-Cyclobutyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;

[0885] 1-[4-(3-{5-[(R)-(4-Cyclobutyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone;

[0886] 1-[4-(3-{5-[(R)-(3,5-Difluoro-4-isopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-

[0887] [1.2.4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone;

[0888] 2-(3-{5-[(R)-(3,5-Difluoro-4-isopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-

[0889] [1.2.4]oxadiazol-5-yl)-propan-2-ol;

[0890] 1-[4-(3-{5-[(R)-(4-Cyclobutoxy-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone;

[0891] 2-[3-(5-{(1,3-Dimethyl-azetidin-3-yl)-[4-(1-ethyl-propyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]- propan-2-ol;

[0892] 1-{4-[3-(5-{(1,3-Dimethyl-azetidin-3-yl)-[4-(1-ethyl-propyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]- piperidin-1 -yl}-ethanone;

[0893] 2-[3-(5-{(1,3-Dimethyl-azetidin-3-yl)-[4-(2,2-dimethyl-propyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5- yl]-propan-2-ol;

[0894] 1-{4-[3-(5-{(1,3-Dimethyl-azetidin-3-yl)-[4-(2,2-dimethyl-propyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-

[0895] 5-yl]-piperidin-1-yl}-ethanone;

[0896] 1-{4-[3-(5-{(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-methyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-

[0897] [1.2.4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone;

[0898] 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-propyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan- 2-ol;

[0899] 2-(3-{5-[(R)-(4-Cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;

[0900] 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2- ol;

[0901] 2-(3-{5-[(R)-(4-Butyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2- ol; 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;

[0902] 2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(2,2,2-trifluoro-ethyl)-phenyl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-

[0903] 5-yl]-propan-2-ol;

[0904] 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isobutyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;

[0905] 2-(3-{5-[(R)-(4-Cyclobutoxy-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;

[0906] 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropenyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;

[0907] 1-{4-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(2,2,2-trifluoro-ethyl)-phenyl]-methyl}-pyridin-3-yl)-

[0908] [1.2.4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone;

[0909] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-propyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone;

[0910] 1-[4-(3-{5-[(R)-Hydroxy-(1-isopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-

[0911] 5-yl)-piperidin-1-yl]-ethanone;

[0912] 1-[4-(3-{5-[(R)-[1-(2,2-Difluoro-ethyl)-3-methyl-azetidin-3-yl]-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-

[0913] [1.2.4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone;

[0914] 1-[4-(3-{5-[(R)-Hydroxy-[1-(2-hydroxy-ethyl)-3-methyl-azetidin-3-yl]-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-

[0915] [1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone;

[0916] 1-[4-(3-{5-[(R)-(1-Cyclopropylmethyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-

[0917] [1.2.4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone;

[0918] 1-{4-[3-(5-{(R)-Hydroxy-(4-isopropyl-phenyl)-[1-(2-methoxy-ethyl)-3-methyl-azetidin-3-yl]-methyl}-pyridin-3-yl)-

[0919] [1.2.4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone;

[0920] 1-{4-[3-(5-{(R)-Hydroxy-(4-isopropyl-phenyl)-[3-methyl-1-(3,3,3-trifluoro-propyl)-azetidin-3-yl]-methyl}-pyridin-3-yl)-

[0921] [1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone;

[0922] 1-[4-(3-{5-[(R)-Hydroxy-(4-isopropyl-phenyl)-(3-methyl-1-propyl-azetidin-3-yl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-piperidin-1 -yl]-ethanone;

[0923] 1-[4-(3-{5-[(R)-(1-Ethyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-piperidin-1 -yl]-ethanone;

[0924] 1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-piperidin-1-yl)- ethanone;

[0925] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1,1-trifluoro-2-methyl-but-3- yn-2-ol; Cyclopropanecarboxylic acid (3-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}- 1 , 1 -dimethyl-prop-2-ynyl)-amide;

[0926] N-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 -dimethyl-prop-2-ynyl)- isobutyramide;

[0927] N-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 -dimethyl-prop-2-ynyl)-

[0928] 2-methoxy-acetamide;

[0929] 3-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 -dimethyl-prop-2-ynyl)- oxazolidin-2-one;

[0930] 1 -(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 -dimethyl-prop-2-ynyl)- pyrrolidin-2-one;

[0931] 1 -(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 -dimethyl-prop-2-ynyl)-3- methyl-imidazolidin-2-one;

[0932] 1 -(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 -dimethyl-prop-2-ynyl)- imidazolidin-2-one;

[0933] 3-(1-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclopropyl)- oxazolidin-2-one;

[0934] 1-((R)-2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-2-methyl- pyrrolidin-1-yl)-ethanone;

[0935] 1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-4-hydroxy-piperidin-

[0936] 1-yl)-ethanone;

[0937] 1-[4-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-hydroxy-1-methyl- prop-2-ynyl)-piperidin-1-yl]-ethanone;

[0938] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-hydroxy-prop-2-ynyl)- piperidin-1-yl]-ethanone;

[0939] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-prop-2-ynyl)-piperidin-1- yl]-ethanone;

[0940] 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-hydroxy-prop-2-ynyl)-

[0941] 4-methyl-piperidin-1-yl]-ethanone;

[0942] 1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-4-methyl-piperidin-1- yl)-ethanone;

[0943] (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(1-methanesulfonyl-piperidin-4-ylethynyl)-pyridin-3-yl]- methanol;

[0944] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-4-methyl-piperidine-1- sulfonic acid methylamide; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-methanesulfonyl-3-methyl-but-1-ynyl)-pyridin-3-yl]- methanol;

[0945] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclopropanesulfonic acid dimethylamide;

[0946] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclopropanesulfonic acid amide;

[0947] (R)-[5-(3-Cyclopropanesulfonyl-3-methyl-but-1-ynyl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)- methanol;

[0948] (R)-3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-1- methyl-pyrrolidin-2-one;

[0949] (S)-3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-1- methyl-pyrrolidin-2-one;

[0950] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3,4-dihydro-2H- pyrano[3,2-b] pyridin-4-ol;

[0951] 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-1-methyl- 1,3-dihydro-indol-2-one;

[0952] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1H-indazol-3-yl)-but-3-yn-2- ol;

[0953] 4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-indazol-3-yl)- but-3-yn-2-ol;

[0954] 2-(1-Cyclopropyl-1H-pyrazol-3-yl)-4-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3- yl}-but-3-yn-2-ol;

[0955] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-pyrimidin-4-yl)- but-3-yn-2-ol;

[0956] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(5-methyl-pyrazin-2-yl)-but-

[0957] 3-yn-2-ol;

[0958] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-thiazol-5-yl)-but-3- yn-2-ol;

[0959] 2-(6-Cyclopropyl-pyrimidin-4-yl)-4-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3- yl}-but-3-yn-2-ol;

[0960] (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyrimidin-4- yl)-but-3-yn-2-ol;

[0961] (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyrimidin-4- yl)-but-3-yn-2-ol; N-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 -dimethyl-prop-2-ynyl)- acetamide;

[0962] (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyrimidin-4- yl)-but-3-yn-2-ol;

[0963] (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyrimidin-4- yl)-but-3-yn-2-ol;

[0964] (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-pyrimidin-4- yl)-but-3-yn-2-ol;

[0965] (S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-pynmidin-4- yl)-but-3-yn-2-ol;

[0966] (S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-pynmidin-4- yl)-but-3-yn-2-ol;

[0967] (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-pyrimidin-4- yl)-but-3-yn-2-ol;

[0968] (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2,6-dimethyl-pyrimidin- 4-yl)-but-3-yn-2-ol;

[0969] (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2,6-dimethyl-pyrimidin-

[0970] 4-yl)-but-3-yn-2-ol;

[0971] (R)-(S)-2-(2,6-Dimethoxy-pyrimidin-4-yl)-4-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]- pyridi n-3-y l}-but-3-yn-2-ol ;

[0972] (S)-2-(2,6-Dimethoxy-pyrimidin-4-yl)-4-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]- pyridin-3-yl}-but-3-yn-2-ol;

[0973] (R)-2-(2,6-Dimethoxy-pyrimidin-4-yl)-4-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]- pyridi n-3-y l}-but-3-yn-2-ol ;

[0974] (S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-6-methyl- pyrimidin-4-yl)-but-3-yn-2-ol;

[0975] (R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-6-methyl- pyrimidin-4-yl)-but-3-yn-2-ol;

[0976] (R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-2-methyl- pyrimidin-4-yl)-but-3-yn-2-ol;

[0977] (S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-2-methyl- pyrimidin-4-yl)-but-3-yn-2-ol;

[0978] (S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-2-methyl- pyrimidin-4-yl)-but-3-yn-2-ol; (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-2-methyl- pyrimidin-4-yl)-but-3-yn-2-ol;

[0979] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-trifluoromethyl-pyrimidin-

[0980] 4-yl)-but-3-yn-2-ol;

[0981] 2-(6-Difluoromethyl-pyrimidin-4-yl)-4-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-

[0982] 3-yl}-but-3-yn-2-ol;

[0983] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(1-pyridin-2-yl-cyclopropylethynyl)-pyridin-3-yl]-methanol;

[0984] (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[1-(6-methyl-pyrimidin-4-yl)-cyclopropylethynyl]-pyridin-3-yl}- methanol;

[0985] 1-[4-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-piperidin-1-yl]- ethanone;

[0986] 4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 , 1 -trifluoro-2-methyl-butan-

[0987] 2-ol;

[0988] 3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1 -dimethyl-propyl)- oxazolidin-2-one;

[0989] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1 -dimethyl-propyl)- pyrrolidin-2-one;

[0990] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1-dimethyl-propyl)-3- methyl-imidazolidin-2-one;

[0991] 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1 -dimethyl-propyl)- imidazolidin-2-one;

[0992] 1-[(S)-2-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-2-methyl- pyrrolidin-1-yl]-ethanone;

[0993] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1H-indazol-3-yl)-butan-2-ol;

[0994] 2-(1-Cyclopropyl-1H-pyrazol-3-yl)-4-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3- yl}-butan-2-ol;

[0995] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-pyrimidin-4-yl)- butan-2-ol;

[0996] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(5-methyl-pyrazin-2-yl)- butan-2-ol;

[0997] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-thiazol-5-yl)- butan-2-ol;

[0998] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(3-methyl-isoxazol-5-yl)-but-

[0999] 3-yn-2-ol; 4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-imidazol-2-yl)- but-3-yn-2-ol;

[1000] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(5-methyl-thiophen-2-yl)-but-

[1001] 3-yn-2-ol;

[1002] 4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-pyrrol-2-yl)- but-3-yn-2-ol;

[1003] (R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-trifluoromethyl- pyrimidin-4-yl)-but-3-yn-2-ol;

[1004] (S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-trifluoromethyl- pyrimidin-4-yl)-but-3-yn-2-ol;

[1005] (S)-(R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-trifluoromethyl- pyrimidin-4-yl)-but-3-yn-2-ol;

[1006] (R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-trifluoromethyl- pyrimidin-4-yl)-but-3-yn-2-ol;

[1007] 4-(5-{(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-2-(6- methyl-pyridin-2-yl)-but-3-yn-2-ol;

[1008] 4-(5-{(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-methyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-2-(6-methyl- pyridin-2-yl)-but-3-yn-2-ol;

[1009] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)- but-3-yn-2-ol;

[1010] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-hydroxy-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3-yn-

[1011] 2-ol;

[1012] 4-{5-[(R)-(4-tert-Butyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3- yn-2-ol;

[1013] 4-{5-[(R)-(3-Ethyl-1-methyl-azetidin-3-yl)-hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-

[1014] 2-yl)-but-3-yn-2-ol;

[1015] 4-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(2,2,2-trifluoro-ethyl)-phenyl]-methyl}-pyridin-3-yl)-2-(6-methyl- pyridin-2-yl)-but-3-yn-2-ol;

[1016] 4-{5-[(S)-(3-Fluoro-1-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)- but-3-yn-2-ol;

[1017] 1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-ylethynyl}-piperidin-1-yl)- ethanone;

[1018] N-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-1,1 -dimethyl-prop-2- ynyl)-acetamide; 1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-1,1 -dimethyl-prop-2- ynyl)-pyrrolidin-2-one;

[1019] 4-{5-[(R)-Hydroxy-(1-isopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2- yl)-but-3-yn-2-ol;

[1020] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3- yn-2-ol;

[1021] 4-{5-[(R)-Hydroxy-[1-(2-hydroxy-ethyl)-3-methyl-azetidin-3-yl]-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl- pyridin-2-yl)-but-3-yn-2-ol;

[1022] 4-{5-[(R)-[1-(2,2-Difluoro-ethyl)-3-methyl-azetidin-3-yl]-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl- pyridin-2-yl)-but-3-yn-2-ol;

[1023] 1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxymethyl}-piperidin-1-yl)- ethanone;

[1024] 4-{5-[(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-

[1025] 2-yl)-but-3-yn-2-ol;

[1026] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(2-isopropyl-pyrimidin-4-yl)- pyrrolidin-2-one;

[1027] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(2-methyl-thiazol-5-yl)- pyrrolidin-2-one;

[1028] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(6-methyl-pyridin-3-yl)- pyrrolidin-2-one;

[1029] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(6-isopropyl-pyridin-2-yl)- pyrrolidin-2-one;

[1030] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(6-trifluoromethyl-pyridin-3- yl)-pyrrolidin-2-one;

[1031] 1 -{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(1 -methyl-1 H-pyrazol-4-yl)- pyrrolidin-2-one;

[1032] 1 -{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(1 ,3-dimethyl-1 H-pyrazol-4- yl)-pyrrolidin-2-one;

[1033] 4-(1-Difluoromethyl-1H-pyrazol-4-yl)-1-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]- pyridin-3-yl}-pyrrolidin-2-one;

[1034] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(2-methyl-2H-[1,2,3]triazol-

[1035] 4-yl)-pyrrolidin-2-one;

[1036] 4-(1-Acetyl-piperidin-4-yl)-1-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}- pyrrolidin-2-one; 5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-hexahydro-furo[2,3-c]pyrrol-

[1037] 4-one;

[1038] 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4-(6-isopropyl-pyridin-2-yl)- pyrrolidin-2-one;

[1039] 1-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-7,8-dihydro-5H-pyrido[4, 3- d]pyrimidin-6-yl)-ethanone;

[1040] 1-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-7,8-dihydro-5H-

[1041] [1,6]naphthyridin-6-yl)-ethanone;

[1042] 1-[4-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrimidin-5-yl)-piperidin- 1-yl]-ethanone; and

[1043] 1-[4-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrimidin-4-yl)-piperidin-

[1044] 1-yl]-ethanone.

[1045] 35) Another embodiment relates to a compound according to embodiment 1) selected from a group consisting of

[1046] (R)-2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- 1,1,1 -trifluoro-propan-2-ol;

[1047] 2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;

[1048] 2-(3-{5-[(S)-(1-Cyclopropyl-3-fluoro-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-

[1049] 5-yl)-propan-2-ol; and

[1050] 2-(3-{5-[(R)-(4-Butyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2- ol.

[1051] 36) Another embodiment relates to a compound according to embodiment 1) selected from a group consisting of 4-{5-[(R)-Hydroxy-[1-(2-hydroxy-ethyl)-3-methyl-azetidin-3-yl]-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl- pyridin-2-yl)-but-3-yn-2-ol;

[1052] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)- but-3-yn-2-ol;

[1053] (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyrimidin-4- yl)-but-3-yn-2-ol; and

[1054] 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-hydroxy-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3-yn-

[1055] 2-ol.

[1056] 37) Another embodiment relates to a compound according to embodiment 1) selected from a group consisting of 1-[4-(3-{5-[(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}- [1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone; 1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone;

[1057] 1-[4-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-propyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone; and

[1058] 1-[4-(3-{5-[(R)-Hydroxy-(1-isopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-

[1059] 5-yl)-piperidin-1-yl]-ethanone.

[1060] 38) Another aspect of the present invention relates to compounds of embodiment 1), which are also compounds of formula (Ip), wherein

[1061] Formula (Ip)

[1062] A represents a 6-membered heteroaryl containing from one to three ring nitrogen atom(s) (notably one or two ring nitrogen atoms; especially one or two ring nitrogen atoms in n?efa-position(s) and / or para- position of A with respect to the point of attachment of A to the rest of the molecule), wherein said 6-membered heteroaryl is independently unsubstituted, mono-, di- or tri-substituted (notably mono- or di-substituted in meta- and / or para- position of A with respect to the point of attachment of A to the rest of the molecule), wherein the substituent(s), if any, is(are) independently selected from

[1063] > halogen (especially fluorine);

[1064] > cyano;

[1065] > Ci-4-alkyl (notably methyl, ethyl, propyl, or isopropyl; especially methyl, ethyl, or propyl) which is unsubstituted or mono-substituted with

[1066] • Ci-3-alkoxy (especially methoxy);

[1067] • fluoro-phenoxy (especially 4-fluoro-phenoxy);

[1068] • benzyl-oxy;

[1069] • C3-6-cycloalkyl which is optionally fused with a pyridine ring (notably at positions 2 and 3 adjacent to the nitrogen atom of said pyridine ring), wherein said C3-6-cycloalkyl is unsubstituted or mono-substituted with hydroxy (notably at the point of attachment of the C3-6-cycloalkyl to the Ci-4-al kyl);

[1070] • pyrazolyl (notably pyrazol-4-yl) which is unsubstituted or mono-substituted with Ci-3-alkyl (especially methyl);

[1071] • tetrahydropyranyl (notably tetrahydropyran-4-yl) which is unsubstituted or mono-substituted with hydroxy (especially 4-hydroxy-tetrahydropyran-4-yl); • indolyl (especially indol-2-yl);

[1072] • N-(Ci-3-alkyl)-amino-carbonyl-oxy; or

[1073] • 1 - (C 1 -4-al ky l-oxy-car bo nyl)-3-hyd roxy azeti d i n-3-y I ;

[1074] [in particular such Ci-4-al kyl which is unsubstituted or mono-substituted as defined above is methyl, ethyl, isopropyl, 2-(1-hydroxy-cyclopropyl)-ethyl, 2-(1-hydroxy-cyclobutyl)-ethyl, 2-(1-hydroxy-cyclopentyl)-ethyl, 3- methoxy-propyl, 4-fluoro-phenoxy-methyl, benzyl-oxy-methyl, N-(isopropyl)-amino-carbonyl-oxy-methyl, 2-(1- (tert-butoxy-carbonyl)-3-hydroxyazetidin-3-yl)-ethyl, 2-(1-methyl-pyrazol-4-yl)-ethyl, 2-(tetrahydropyran-4-yl)- ethyl, 2-(4-hydroxy-tetrahydropyran-4-yl)-ethyl, 2-(indol-2-yl)-ethyl, 2-(8-hydroxy-5,6,7,8-tetrahydroquinolin-8- yl)-ethyl, or 2-(7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl)-ethyl]

[1075] > C3-5-alkenyl which is unsubstituted (especially isopropenyl) or mono-substituted with hydroxy (especially 4- hydroxy-but-1 -en-2-yl);

[1076] > tetrahydropyranyl (especially tetrahydropyran-4-yl);

[1077] > hydroxy-Ci-6-alkyl which is optionally further substituted with one or more fluorine atoms (especially 3-hydroxy- propyl, 4-hydroxy-butyl, 3-hydroxy-butyl, 3-hydroxy-3-methyl-butyl, 3-hydroxy-4-methyl-pentyl, or 2,2-difluoro- 3-hydroxy-prop-1-yl);

[1078] > C3-5-alkyl (especially n-propyl, n-butyl, or n-pentyl) which is substituted with hydroxy and RA1(notably both substituents at position 3 with respect to the point of attachment of said C3-5-alkyl to the rest of the molecule), wherein

[1079] • RA1represents

[1080] ■tetrahydropyranyl (especially tetrahydropyran-4-yl);

[1081] ■phenyl which is unsubstituted or mono-substituted with fluorine (especially 3-fl uoro-pheny I) or Ci-3-alkoxy (especially 2-methoxy-phenyl or 4-methoxy-phenyl); or

[1082] ■5- or 6-membered heteroaryl containing one or two ring heteroatom(s) being independently selected from nitrogen or sulfur (notably thiazolyl, pyrazolyl, pyridinyl, or pyrimidinyl; especially thiazol-4-yl, pyrazol-3-yl, pyrazol-4-yl, pyridin-2-yl, pyrimidin-2-yl, or pyrimidin-4-yl), wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono- or di- substituted, and wherein the substituent(s), if any, is(are) independently selected from Ci-3-alkyl (especially methyl) or Ci_3-alkoxy (especially methoxy);

[1083] [in particular such C3-5-alkyl which is substituted as defined above is 3-hydroxy-3-(tetrahydropyran-4-yl)-propyl, 3-hydroxy-3-phenyl-propyl, 3-hydroxy-3-phenyl-butyl, 3-hydroxy-3-(m-fluoro-phenyl)-butyl, 3-hydroxy-3-(o- methoxy-phenyl)-butyl, 3-hydroxy-3-(p-methoxy-phenyl)-butyl, 3-hydroxy-3-(1,5-dimethyl-pyrazol-3-yl)-butyl, 3-hydroxy-3-(1-methyl-pyrazol-3-yl)-butyl, 3-hydroxy-3-(1,5-dimethyl-pyrazol-3-yl)-propyl, 3-hydroxy-3-(2- methyl-thiazol-4-yl)-butyl, 3-hydroxy-3-(6-methoxy-pyridin-2-yl)-butyl, 3-hydroxy-3-(pyrimidin-2-yl)-butyl, 3- hydroxy-3-(6-methoxy-pyrimidin-4-yl)-butyl, 3-hydroxy-3-(1,3-dimethyl-pyrazol-4-yl)-propyl, 3-hydroxy-3-(2- methyl-thiazol-4-yl)-propyl, 3-hydroxy-3-(pyridin-2-yl)-pentyl, or 3-hydroxy-3-(6-methoxy-pyridin-2-yl)-pentyl]

[1084] > C3-6-cycloalkyl which is unsubstituted, mono-, or di-substituted with Ci_3-alkyl (especially methyl, ethyl, isopropyl), hydroxy or hydroxy-Ci.3-alkyl (especially 1 -hydroxy-1 -methyl-ethyl), wherein optionally one ring carbon atom of said C3.6-cycloalkyl is replaced by an oxygen atom;

[1085] [in particular such C3.6-cycloalkyl which is unsubstituted, mono-, or di-substituted as defined above is cyclopropyl, cyclopentyl, 3-hydroxy-cyclopentyl, 3-hydroxy-3-methyl-cyclopentyl, 3-hydroxy-3-ethyl- cyclopentyl, 3-hydroxy-3-isopropyl-cyclopentyl, 2-(2-hydroxy-isopropyl)-cyclopropyl, 4-hydroxy-4-methyl- cyclohextyl, tetrahydrofuran-3-yl, tetrahydrofuran-2-yl, tetrahydropyran-4-yl, 5-methyl-tetrahydrofuran-2-yl, or 5,5-dimethyl-tetrahydrofuran-2-yl]

[1086] > C4-6-cycloalkenyl (notably cyclopentenyl; especially cyclopent- 1 -en- 1 -y I) which is unsubstituted, mono-, or di- substituted with Ci_3-al kyl, oxo (i.e. =0), or hydroxy, wherein optionally one ring carbon atom of said C4.6- cycloalkenyl is replaced by an oxygen atom;

[1087] [in particular such C4.6-cycloalkenyl which is unsubstituted, mono-, or di-substituted as defined above is 3-oxo- cyclopent-1 -en-1 -yl, 3-hydroxy-3-methyl-cyclopent-1-en-1-yl, 2,3-dihydro-furan-3-yl, or 5-methyl-furan-2-yl]

[1088] > -0-R°, wherein

[1089] • R° represents

[1090] ■Ci-4-alkyl (especially methyl, ethyl, isopropyl, sec-butyl, or isobutyl);

[1091] ■hydroxy-Ci-5-alkyl (especially 2-hydroxy-ethyl, 3-hydroxy-propyl, 2-hydroxy-2-methyl-propyl, or 3- hydroxy-3-methyl-butyl);

[1092] ■Ci_3-alkoxy-C2-3-alkyl (especially 2-methoxy-ethyl);

[1093] ■C3-6-cycloalkyl (especially cyclopentyl or cyclohexyl) which is unsubstituted, mono-, or di-substituted with Ci-3-alkyl (especially methyl), hydroxy or Ci.3-alkoxy (especially methoxy);

[1094] ■tetrahydropyranyl (especially tetrahydropyran-4-yl);

[1095] ■tetrahydropyranyl-Ci-3-alkyl (especially tetrahydropyran-4-yl-methyl);

[1096] ■oxetanyl-Ci-3-alkyl (especially oxetan-3-yl-methyl);

[1097] ■phenyl;

[1098] ■benzyl;

[1099] ■benzy l-oxy-Ci _3-al kyl (especially 2-(benzyl-oxy)-ethyl);

[1100] ■pyridinyl-Ci_3-al kyl (especially 2-(pyridin-2-yl)-ethyl);

[1101] ■(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-methyl; or

[1102] ■2-(3,5-dimethyl-1,2,4-triazol-1-yl)-ethyl; [in particular such -0-R° is methoxy, ethoxy, isopropoxy, isobutoxy, sec-butoxy, phenoxy, benzyloxy, 2- (benzyloxy)-ethoxy, 2-methoxy-ethoxy, oxetan-3-yl-methoxy, 3-hydroxy-propoxy, cyclohexyl-oxy, 4-hydroxy- cyclohexyl-oxy, 4-methyl-4-hydroxy-cyclohexyl-oxy, 2-hydroxy-2-methyl-propoxy, 2-hydroxy-ethoxy, 3- hydroxy-3-methyl-butoxy, tetrahydropyran-4-yl-oxy, tetrahydropyran-4-yl-methoxy, 3-methoxy-cyclopentyl- oxy, (3-cyclopropyl-1,2,4-oxadiazol-5-yl)-methoxy, or 2-(3,5-dimethyl-1 ,2,4-triazol-1-yl)-ethoxy]

[1103] > -CºC-RT1, wherein

[1104] > RT1represents

[1105] ■hydroxy-Ci-4-alkyl (especially hydroxy-methyl, 1 -hydroxy-ethyl, 2-hydroxy-ethyl, 1-hydroxy-2-methyl- propyl, or 1 -hydroxy-1 -methyl-ethyl);

[1106] ■Ci_3-alkoxy-Ci_3-alkyl (especially methoxy-methyl);

[1107] ■C3-6-cycloalkyl which is mono-substituted with hydroxy (notably at the point of attachment of the C3.6- cycloalkyl to the rest of the molecule; especially 1 -hydroxy-cyclopropyl, 1 -hydroxy-cyclobutyl, or 1- hydroxy-cyclopentyl);

[1108] ■C3-6-cycloalkyl (notably cyclopentyl or cyclohexyl) fused with a pyridine ring (notably at positions 2 and 3 of the pyridine ring), wherein said C3.6-cycloalkyl is mono-substituted with hydroxy (notably at position 1 of the C3.6-cycloalkyl ring) (especially 8-hydroxy-5,6,7,8-tetrahydroquinolin-8-yl or 7- hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl);

[1109] ■pyrazolyl (notably pyrazol-4-yl) which is mono- substituted with methyl (especially 1-methyl-pyrazol- 4-yl);

[1110] ■tetrahydropyranyl (especially tetrahydropyran-4-yl) which is unsubstituted or mono-substituted with hydroxy (especially 4-hydroxy-tetrahydropyran-4-yl);

[1111] ■indolyl (notably indol-2-yl); or

[1112] ■hydroxy-azetidinyl (notably 3-hydroxy-azetidin-3-yl) which is N-substituted with C -alkoxy-carbonyl (especially isopropyl-carbonyl or tert-butoxy-carbonyl);

[1113] [in particular such -CºC-RT1is 3-hydroxy-prop-1 -yn-1 -yl, 4-hydroxy-but-1 -yn-1 -yl, 3-hydroxy-but-1-yn-1-yl, 3- hydroxy-3-methyl-but-1 -yn-1 -yl, 3-hydroxy-4-methyl-pent-1-yn-1-yl, 3-methoxy-prop-1 -yn-1 -yl, (1-hydroxy- cyclopropyl)-ethynyl, (l-hydroxy-cyclobutyl)-ethynyl, (l-hydroxy-cyclopentyl)-ethynyl, (8-hy d roxy-5, 6,7,8- tetrahydroquinolin-8-yl)-ethynyl, (7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl)-ethynyl, (1-methyl- pyrazol-4-yl)-ethynyl, (tetrahydropyran-4-yl)-ethynyl, (4-hydroxy-tetrahydropyran-4-yl)-ethynyl, indol-2-yl- ethynyl, (1-(isopropyl-carbonyl)-3-hydroxy-azetidin-3-yl)-ethynyl, or (1-(tert-butoxy-carbonyl)-3-hydroxy- azetidin-3-yl)-ethynyl]

[1114] > -CºC-C(OH)(RT2)(RT3), wherein

[1115] > RT2represents hydrogen or Ci.3-alkyl (especially methyl or ethyl); > RT3represents

[1116] ■phenyl which is unsubstituted or mono-substituted, wherein the substituent(s), if any, is(are) independently selected from Ci_3-alkoxy (notably methoxy) or halogen (notably fluorine);

[1117] [in particular such phenyl which is unsubstituted or mono-substituted is 3-fluoro-phenyl, 4-methoxy- phenyl, or 2-methoxy-phenyl]

[1118] ■5- to 6-membered heteroaryl containing one or two ring heteroatom(s) being independently selected from nitrogen or sulfur (notably thiazolyl, pyrazolyl, pyridinyl, or pyrimidinyl; especially thiazol-4-yl, pyrazol-3-yl, pyrazol-4-yl, pyridin-2-yl, pyrimidin-2-yl, or pyrimidin-4-yl), wherein said 5- or 6- membered heteroaryl is independently unsubstituted, mono- or di- substituted, and wherein the substituent(s), if any, is(are) independently selected from Ci_3-alkyl (especially methyl) and Ci_3- alkoxy (especially methoxy); or

[1119] [in particular such 5- to 6-membered heteroaryl is 1 -methyl-pyrazol-3-yl, 1,3-dimethyl-pyrazol-4-yl, 1,5-dimethyl-pyrazol-3-yl, 2-methyl-thiazol-4-yl, pyridin-2-yl, 6-methoxy-pyridin-2-yl, pyrimidin-2-yl, pyrimidin-4-yl, or 1,5-dimethyl-pyrazol-3-yl]

[1120] ■tetrahydropyranyl (especially tetrahydropyran-4-yl);

[1121] [in particular such -CºC-C(OH)(RT2)(RT3) is 3-hydroxy-3-(tetrahydropyran-4-yl)-prop-1-yn-1-yl, 3-hydroxy-3- phenyl-prop-1-yn-1-yl, 3-hydroxy-3-(2-methyl-thiazol-4-yl)-prop-1-yn-1-yl, 3-hy droxy-3-(1 , 3-d i methy l-pyrazol- 4-yl)-prop- 1 -y n- 1 -y 1 , 3-hydroxy-3-phenyl-but-1-yn-1-yl, 3-hydroxy-3-(1-methyl-pyrazol-3-yl)-but-1-yn-1-yl, 3- hydroxy-3-(1,5-dimethyl-pyrazol-3-yl)-but-1-yn-1-yl, 3-hydroxy-3-(1 -methyl-pyrazol-3-yl)-but-1 -yn-1 -yl, 3- hydroxy-3-(pyrimidin-2-yl)-but-1-yn-1-yl, 3-hydroxy-3-(1 -methyl-pyrazol-3-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(3- fluoro-phenyl)-but-1-yn-1-yl, 3-hydroxy-3-(6-methyl-pyrimidin-4-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(pyridin-2-yl)- pent-1-yn-1-yl, 3-hydroxy-3-(6-methoxy-pyridin-2-yl)-but-1-yn-1-yl, 3-hydroxy-3-(6-methoxy-pyridin-2-yl)-pent- 1-yn-1-yl, 3-hydroxy-3-(4-methoxy-phenyl)-but-1-yn-1-yl, or 3-hydroxy-3-(2-methoxy-phenyl)-but-1-yn-1-yl]

[1122] > -NRN1RN2wherein

[1123] • RN1represents Ci_3-alkyl (especially methyl);

[1124] • RN2represents hy d roxy-C i -3-al ky I (especially 2-hydroxy-ethyl) or 2-(benzyl-oxy)-Ci-3-alkyl (especially 2- (benzyl-oxy)-ethyl);

[1125] • or RN1and RN2form, together with the nitrogen to which they are attached, a heterocyclic ring of 4 to 6 members (notably 5 to 6 members), wherein the members needed to complete said heterocyclic ring are each independently selected from -CH2-, -0-, -(C=0)-, -CHRX- and -C(RY)2-; wherein said heterocyclic ring does not contain more than one member independently selected from the group consisting of -0- and -(C=0)-; wherein said heterocyclic ring does not contain more than two members selected from the group consisting of -CHRX-; and wherein said heterocyclic ring does not contain more than two members selected from the group consisting of -C(RY)2-; wherein Rxindependently represents fluorine, methyl, isopropyl, isobutyl, tert-butyl, hydroxy, trifluoromethyl, hydroxy-methyl, 1 -hydroxy-ethyl, 1-hydroxy-1- methyl-ethyl, cyclopropyl, 2-methoxy-ethyl, 4-methyl-thiazol-2-yl, phenyl, benzyl, tetrahydropyran-4-yl, 1,2,4-oxadiazolyl, 3-methyl-1,2,4-oxadiazol-5-yl, pyridin-2-yl, or 1-methoxy-methyl; and wherein RYindependently represents fluorine, hydroxy, cyclopropyl, methyl, hydroxy-methyl, or trifluoromethyl [notably such -NRN1RN2is pyrrolidinyl; 2-pyrrolidonyl; oxazolidinonyl (especially 1,3-oxazolidin-2-on-3-yl); piperidinyl; or morpholinyl, optionally independently substituted with one or two substituents independently selected from a group consisting of Rxand R11];

[1126] [in particular such -NRN1RN2is pyrrolidin-1-yl, 3-fluoro-pyrrolidin-1-yl, 3,3-difluoro-pyrrolidin-1-yl, 3,4-difluoro- pyrrolidin-1-yl, 3-isopropyl-pyrrolidin-1-yl, 3,3-dimethyl-pyrrolidin-1-yl, 3-hydroxy-pyrrolidin-1-yl, 2-methyl- pyrrolidin-1-yl, 3-hydroxy-3-methyl-pyrrolidin-1-yl, 3-(hydroxy-methyl)-pyrrolidin-1-yl, 2-(hydroxy-methyl)- pyrrolidin-1-yl, 3-(1-hydroxy-ethyl)-pyrrolidin-1-yl, 3-hydroxy-3-cyclopropyl-pyrrolidin-1-yl, 3-hydroxy-3- trifluoromethyl-pyrrolidin-1-yl, 3-trifl uoromethy l-pyrrol id i n-1 -yl , 3-(1-hydroxy-1-methyl-ethyl)-pyrrolidin-1-yl, 3- (1-hydroxy-ethyl)-pyrrolidin-1-yl, 3-(hydroxy-methyl)-3-methyl-pyrrolidin-1-yl, 1,3-oxazolidin-2-on-3-yl, 5-(tert- butyl)-1 , 3-oxazol idin-2-on-3-y 1 , 5-phenyl-1 ,3-oxazolidin-2-on-3-yl, 5-benzyl-1 , 3-oxazol idin-2-on-3-y 1 , 5- isopropyl-1 ,3-oxazolidin-2-on-3-yl, 5-(tetrahydropyran-4-yl)-1 , 3-oxazol idin-2-on-3-y 1 , 5,5-dimethyl-1 ,3- oxazolid i n-2-on-3-yl , morpholin-4-yl, piperidin-1-yl, 4-hydroxy-piperidin-1-yl, 3-hydroxy-piperidin-1-yl, 3- (tetrahydropyran-4-yl)-pyrrolid-2-on-1-yl, N-methyl-N-(2-(benzyl-oxy)-ethyl)-amino, N-methyl-N-(2-hydroxy- ethyl)-amino, pyrrolid-2-on-1-yl, 4-phenyl-pyrrolid-2-on-1-yl, 4-isopropyl-pyrrolid-2-on-1-yl, 3-isopropyl- pyrrolid-2-on-1-yl, 4,4-dimethyl-pyrrolid-2-on-1-yl, 3-(piperidin-4-yl)-pyrrolid-2-on-1-yl, 4-isobutyl-pyrrolid-2-on- 1-yl, 4-cyclopropyl-pyrrolid-2-on-1-yl, 4-trifluoromethyl-pyrrolid-2-on-1-yl, 3-(2-methoxy-ethyl)-pyrrolid-2-on-1- yl, 4-(2-methoxy-ethy l)-py rrol id-2-on- 1 -y 1 , 2,2,6,6-tetrafluoro-morpholin-4-yl, 2,6-dimethyl-morpholin-4-yl, 2- (methoxy-methyl)-morpholin-4-yl, 3-(3-methy I- 1 , 2, 4-oxadi azol-5-y I )-pyrrol idi n- 1 -y I, 3-(4-methyl-thiazol-2-yl)- pyrrolidin-1-yl, or 3-(phenyl)-pyrrolidin-1-yl]

[1127] > -(C=0)-N(RN3)(RN4), wherein

[1128] • RN3represents hydrogen; and

[1129] RN4represents C3-6-cycloalkyl (especially cyclopentyl) or tetrahydropyranyl (especially tetrahydropyran-4- yl); or

[1130] • RN3and RN4form, together with the nitrogen to which they are attached, pyrrolidinyl;

[1131] [in particular such -(C=0)-N(RN3)(RN4) is N-cyclopentyl-amino-carbonyl, N-(tetrahydropyran-4-yl)-amino- carbonyl, or pyrrolidinyl-carbonyl] > piperidin-4-yl or pyrrolidin-3-yl which independently are mono-substituted at the nitrogen ring atom, wherein the substituent is selected from Ci.4-alkoxy-carbonyl (especially tert-butoxy-carbonyl), pyridinyl (especially pyridin-2-yl), phenyl and (4-methylphenyl)-sulfonyl;

[1132] [in particular such piperidin-4-yl or pyrrolidin-3-yl are N-(tert-butoxy-carbonyl)-piperidin-4-yl, N-(tert-butoxy- carbonyl)-pyrrolidin-3-yl, N-(pyridin-2-yl)-piperidin-4-yl, N-(phenyl)-piperidin-4-yl, or N-((4-methylphenyl)- sulfonyl)-piperidin-4-yl]

[1133] > 5-membered heteroaryl containing from one to three (notably two or three; especially three) ring heteroatom(s) independently selected from nitrogen, oxygen and sulfur (notably pyrazolyl, triazolyl, oxazolyl, thiazolyl, oxadiazolyl; especially pyrazol-1-yl, 1,2,3-triazol-1-yl, oxazol-2-yl, thiazol-2-yl, 1,2,4-oxadiazol-5-yl or 1,2,4- oxadiazol-3-yl); wherein said 5-membered heteroaryl is independently unsubstituted, mono-, di-, or tri- substituted (notably mono-substituted; especially mono-substituted in position 3 with respect to the point of attachment of said 5-membered heteroaryl to A), wherein the substituent(s), if any, is(are) independently selected from

[1134] > Ci-4-alkyl which is unsubstituted or mono-substituted with hydroxy or C -alkoxy (especially methoxy and tert-butoxy);

[1135] [in particular such Ci-4-al kyl which is unsubstituted or mono-substituted as defined above is methyl, 1- hydroxy- 1 -methyl-ethyl , 2-hydroxy-2-methyl-propyl, 2-hydroxy-1,1 -dimethyl-ethyl, methoxy-methyl, 2- methoxy-ethyl, 1 -methoxy-1 -methyl-ethyl, 2-methoxy-2-methyl-propyl, 2-methoxy-1 , 1 -dimethyl-ethyl, tert- butoxy-methyl; preferably such Ci_4-alkyl group is 1 -hydroxy-1 -methyl-ethyl, 2-hydroxy-2-methy l-propy I , or 2-hydroxy-1 , 1 -dimethyl-ethyl]

[1136] > amino-Ci-4-alkyl (especially 2-amino-ethyl or 2-amino-2, 2-dimethyl-ethyl), wherein the amino group is mono- or di-substituted (especially mono-substituted) with Ci_3-alkyl (especially methyl), Ci-3-alkyl- carbonyl including deuterated C i -3-al kyl-carbony I (especially acetyl or acetyl-2, 2, 2-d3), or hydroxy-Ci-3- alkyl-carbonyl (especially hydroxy-methyl-carbonyl);

[1137] [in particular such amino-C -alkyl is N-acetyl-2-amino-ethyl, N-(acetyl-2,2,2-d3)-2-amino-ethyl, N-acetyl- 2-amino-2, 2-dimethyl-ethyl, N-(acetyl-2, 2, 2-d3)-2-amino-2, 2-dimethyl-ethyl, N-methyl-N-(hydroxy-methyl- carbonyl)-2-amino-ethyl, N-methyl-N-acetyl-2-amino-ethyl, or N-methyl-N-(acetyl-2,2,2-d3)-2-amino-ethyl]

[1138] > C3_6-cycloalkyl-L2-, wherein

[1139] ■-L2- represents a bond (i.e. the C3_6-cycloalkyl is directly attached to the rest of the molecule), oxygen,

[1140] Ci_3-alkylene (especially -CH2-, -CH2-CH2-, or -C(CH3)2-), hydroxy-Ci_2-alkylene (especially -CH(OH)- ) or oxy-Ci-2-alkylene (especially -0-CH2-) (wherein the C3-6-cycloalkyl is attached to the oxygen atom of said oxy-Ci-2-alkylene);■C3-6-cycloalkyl is unsubstituted, mono-, or di-substituted with fluorine, Cu-alkyl (especially methyl), Ci_3-alkoxy (especially methoxy), hydroxy, hy d roxy-C i _3-al ky I , or Ci_3-alkoxy-Ci_3-alkyl; wherein optionally one ring carbon atom of said C3_6-cycloalkyl is replaced by an oxygen atom;

[1141] [in particular such C3-6-cycloalkyl-L2- is oxetan-3-yl, cyclobutoxy-methyl, 1 -hydroxy-cyclopropyl, 1- hydroxy-cyclobutyl, 3-hydroxy-cyclobutyl, 1 -hydroxy-cyclopentyl, 3- hy d roxy-3-methy I -cy cl openty 1 , 1- hydroxy-cyclohexyl, 4-hydroxy-cyclohexyl, (1 -hydroxy-cyclohexyl)-methyl, (1 -hydroxy-cyclobutyl)-methyl, 1 -hydroxy-1 -cyclohexylmethyl, 1 -methoxy-cyclobutyl, 1 -methoxy-cyclopentyl, 1 -(1 -(methoxy-methyl)- cyclopropyl)-methyl, tetrahydrofuran-2-yl-methyl, tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, tetrahydropyran-3-yl, tetrahydropyran-4-yl, 4-methyl-tetrahydropyran-4-yl, 2,6-dimethyl-tetrahydropyran- 4-yl, 4-methoxy-tetrahydropyran-4-yl, 4-fl uoro-tetrahy d ropy ran-4-y I , tetrahydropyran-4-yl-methyl, 2- (tetrahydropyran-4-yl)-ethyl, 1-(tetrahydropyran-4-yl)-1-methyl-ethyl, tetrahydropyran-4-yl-oxy-methyl, or (4-methyl-tetrahydropyran-4-yl)-oxy-methyl]

[1142] > piperidin-4-yl which is N-substituted with Ci-3-alkyl-carbonyl (especially acetyl), (hydroxy-Ci-3-alkyl)- carbonyl (especially hydroxymethyl-carbonyl), or C3-5-cycloalkyl-sulfonyl;

[1143] [in particular such piperidin-4-yl is N-acetyl-piperidin-4-yl, N-(hydroxymethyl-carbonyl)-piperidin-4-yl, or N- (cyclopropyl-sulfonyl)-piperidin-4-yl]

[1144] > morpholinyl-L3- (notably (morpholin-4-yl)-L3-), wherein -L3- represents a bond (i.e. the morpholinyl is directly attached to the rest of the molecule) or Ci_2-alkylene; wherein said morpholinyl is unsubstituted or di-substituted with methyl;

[1145] [in particular such morpholinyl-L3- is morpholin-4-yl, morpholin-4-yl-methyl, or (2,6-dimethyl-morpholin-4- yl)-methyl]

[1146] > pyrazolyl-Ci-3-alkyl (especially 2-(pyrazol-1-yl)-ethyl);

[1147] > Ci-3-alkyl-sulfonyl-Ci-3-alkyl (especially methyl-sulfonyl-methyl);

[1148] > 2,2,2-trifluoro-1 -hydroxy-1 -methyl-ethyl;

[1149] > 3-hydroxymethyl-bicyclo[1.1.1]pent-1 -yl;

[1150] > 7-oxa-bicyclo[2.2.1]hept-2-yl; and

[1151] > 6-oxa-sp i ro [2.5] oct- 1 -y I ;

[1152] > 5-oxo-4-oxa-6-azaspiro[2.4]hept-6-yl, 2,2-dimethyl-6-oxo-5-oxa-7-azaspiro[3.4]oct-7-yl, 2-cyclopropyl-6-oxo-

[1153] 5-oxa-7-azaspiro[3.4]oct-7-yl, 2-oxo-1-oxa-3-azaspiro[4.4]non-3-yl, 8,8-difluoro-2-oxo-1-oxa-3- azaspiro[4.5]dec-3-yl, or 8-oxo-7-oxa-9-azadispiro[3.1.4.1]undec-9-yl;

[1154] > 7-aza-bicyclo[2.2.1]hept-7-yl, 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl, 6-oxa-3-aza-bicyclo[3.1.1]hept-3-yl, or 8- oxa-3-azabicyclo[3.2.1]oct-3-yl; > 5-oxo-6-azaspiro[3.4]oct-6-yl, 3-oxo-2-azaspiro[4.4]non-2-yl, 1-oxo-2-azaspiro[4.5]dec-2-yl, 1-oxo-8-oxa-2- azaspiro[4.5]dec-2-yl, 3-oxo-8-oxa-2-azaspiro[4.5]dec-2-yl, or 4-oxo-hexahydro-5H-furo[2,3-c]pyrrol-5-yl;

[1155] > 3-(7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl)propyl or 3-(8-hydroxy-5,6,7,8-tetrahydroquinolin-8- yl)propyl); and

[1156] > 2-(6,7-dihydro-5H-[1]pyrindin-7-ol)-ethyl or 2-(8-hydroxy-5,6,7,8-tetrahydro-quinolin-8-yl)-ethyl;

[1157] B represents phenyl, which is unsubstituted, mono-, di- or tri-substituted (especially mono-substituted in para- position with respect to the point of attachment of B to the rest of molecule), wherein the substituent(s), if any, is(are) independently selected from

[1158] > Ci-5-alkyl (especially methyl, ethyl, n-propyl, isopropyl, or tert-butyl; in particular isopropyl);

[1159] > Ci_3-alkoxy (especially methoxy, ethoxy, or isopropoxy);

[1160] > Ci_3-alkoxy-Ci_4-alkyl (especially 3-methoxy-propyl);

[1161] > Ci-3-fluoroalkyl (especially trifluoromethyl);

[1162] > C3-5-cycloalkyl (especially cyclopropyl or cyclobutyl) which independently is unsubstituted or mono-substituted (notably at the point of attachment of said C3-5-cycloalkyl to the rest of the molecule) with Ci_3-alkyl (especially methyl) or Ci-3-fluoroalkyl (especially trifluoromethyl);

[1163] > C3-5-cycloalkoxy (especially cyclopropoxy or cyclobutoxy); and

[1164] > C1-3-f I uo ro al koxy (especially trifluoromethoxy);

[1165] [in particular such Bis phenyl, 4-methyl-phenyl, 4-ethyl-phenyl, 4-propyl-phenyl, 4-isopropyl-phenyl, 4-tert-butyl-phenyl, 4-cyclopropyl-phenyl, 4-methoxy-phenyl, 4-ethoxy-phenyl, 4-isopropoxy-phenyl, 4-trifluoromethyl-phenyl, 4-(1-methyl- cyclopropyl)-phenyl, 4-cyclobutyl-phenyl, 4-cyclopropoxy-phenyl, 4-cyclobutoxy-phenyl, 4-(trifluoromethoxy)-phenyl, 4- (3-methoxy-propyl)-phenyl, or 4-(1 -trifluoromethyl-cyclopropyl)-phenyl]

[1166] R1represents Ci_3-alkyl (especially methyl), cyano, or halogen (especially fluorine);

[1167] R2represents Ci_4-alkyl (especially methyl, ethyl, n-propyl, isopropyl, tert-butyl or isobutyl), C3-5-cycloalkyl (especially cyclopropyl or cyclobutyl), C3-5-cycloalkyl-Ci-3-alkyl (especially cyclopropyl-methyl), or Ci-3-fluoroalkyl (especially 2,2- difluoroethyl or 2-fluoroethyl).

[1168] 39) A further embodiment relates to compounds of Formula (IP) according to embodiment 38), wherein the characteristics of any one of embodiments 2) to 32) apply mutatis mutandis.

[1169] 40) One embodiment of the present invention relates to compounds according to embodiment 38), wherein A represents pyridinyl, pyrimidinyl, pyrazinyl, orpyridazinyl (notably pyridin-3-yl, pyridin-4-yl, pyrimidin-5-yl, pyrazin-2-yl, or pyridazin- 4-yl; especially pyridin-3-yl), wherein A is independently unsubstituted, mono-, di- or tri-substituted (notably mono- or di-substituted in meta- and / or para- position of A with respect to the point of attachment of A to the rest of the molecule; especially mono-substituted in eia-position of A with respect to the point of attachment of A to the rest of the molecule), wherein the substituent(s), if any, is(are) as defined in embodiment 38).

[1170] 41) Another embodiment of the present invention relates to compounds according to embodiment 38), wherein A represents pyridin-3-yl or pyridin-4-yl, wherein A is independently unsubstituted, mono-, di- or tri-substituted (notably mono- or di-substituted in meta- and / or para- position of A with respect to the point of attachment of A to the rest of the molecule; especially mono-substituted in meia-position of A with respect to the point of attachment of A to the rest of the molecule), wherein the substituent(s), if any, is(are) as defined in embodiment 38).

[1171] 42) Another embodiment of the present invention relates to compounds according to embodiment 38), wherein A is

[1172] > unsubstituted;

[1173] > mono-substituted (especially in meia-position of A with respect to the point of attachment of A to the rest of the molecule), wherein the substituent is as defined in embodiment 38).

[1174] > di-substituted, wherein a first substituent is (notably in meta- position of A with respect to the point of attachment of A to the rest of the molecule) selected from the substituents defined in embodiment 38) (notably excluding halogen (especially fluorine) or cyano); and a second substituent is (notably in para- position of A with respect to the point of attachment of A to the rest of the molecule) selected from halogen (especially fluorine) and cyano.

[1175] [In a sub-embodiment of embodiment 4), A is pyridin-3-yl]

[1176] 43) Another embodiment of the present invention relates to compounds according to any one of embodiments 40) to 42), wherein A is mono-substituted in meia-position of A with respect to the point of attachment of A to the rest of the molecule, wherein the substituent of A is

[1177] > 5-membered heteroaryl containing from one to three (notably two or three; especially three) ring heteroatom(s) independently selected from nitrogen, oxygen and sulfur (notably pyrazolyl, triazolyl, oxazolyl, thiazolyl, oxadiazolyl; especially pyrazol-1-yl, 1,2,3-triazol-1-yl, oxazol-2-yl, thiazol-2-yl, 1,2,4-oxadiazol-5-yl or 1,2,4- oxadiazol-3-yl; preferably 1,2,4-oxadiazol-5-yl or 1,2,4-oxadiazol-3-yl); wherein said 5-membered heteroaryl is independently unsubstituted, mono-, di-, or tri-substituted (notably mono-substituted; especially mono- substituted in position 3 with respect to the point of attachment of said 5-membered heteroaryl to A), wherein the substituent(s), if any, is(are) independently selected from

[1178] > Ci-4-alkyl which is unsubstituted or mono-substituted with hydroxy or Ci_4-alkoxy (especially methoxy and tert-butoxy);

[1179] [in particular such Ci_4-al kyl which is unsubstituted or mono-substituted as defined above is methyl, 1- hydroxy- 1 -methyl-ethyl , 2-hydroxy-2-methyl-propyl, 2-hydroxy-1,1 -dimethyl-ethyl, methoxy-methyl, 2- methoxy-ethyl, 1 -methoxy-1 -methyl-ethyl, 2-methoxy-2-methyl-propyl, 2-methoxy-1 , 1 -dimethyl-ethyl, tert- butoxy-methyl; preferably such Ci-4-alkyl group is 1 -hydroxy-1 -methyl-ethyl, 2-hydroxy-2-methy l-propy I , or 2-hydroxy-1 , 1 -dimethyl-ethyl]

[1180] > amino-Ci-4-alkyl (especially 2-amino-ethyl or 2-amino-2, 2-dimethyl-ethyl), wherein the amino group is mono- or di-substituted (especially mono-substituted) with Cu-alkyl (especially methyl), Ci-3-alkyl- carbonyl including deuterated Ci-3-alkyl-carbonyl (especially acetyl or acetyl-2, 2, 2-d3) or hydroxy-Ci_3- alkyl-carbonyl (especially hydroxy-methyl-carbonyl);

[1181] [in particular such amino-C -alkyl is N -acetyl -2-am i no-ethyl , N-(acetyl-2,2,2-d3)-2-amino-ethyl, N-acetyl- 2-amino-2, 2-dimethyl-ethyl, N-(acetyl-2, 2, 2-d3)-2-amino-2, 2-dimethyl-ethyl, N-methyl-N-(hydroxy-methyl- carbonyl)-2-amino-ethyl, N-methyl-N-acetyl-2-amino-ethyl, or N-methyl-N-(acetyl-2,2,2-d3)-2-amino-ethyl]

[1182] > C3-6-cycloalkyl-L2-, wherein

[1183] ■-L2- represents a bond (i.e. the C3-6-cycloalkyl is directly attached to the rest of the molecule), oxygen, Ci-3-alkylene (especially -CH2-, -CH2-CH2-, or -C(CH3)2-), hydroxy-Ci_2-alkylene (especially -CH(OH)- ) or oxy-Ci-2-alkylene (especially -0-CH2-) (wherein the C3-6-cycloalkyl is attached to the oxygen atom of said oxy-Ci-2-alkylene); and

[1184] ■the C3-6-cycloalkyl is unsubstituted, mono-, or di-substituted with fluorine, Ci-3-alkyl (especially methyl), Ci_3-alkoxy (especially methoxy), hydroxy, hy droxy-C i -3-al ky I , or C i -3- al koxy-C 1 -3-al ky I ; wherein optionally one ring carbon atom of said C3-6-cycloalkyl is replaced by an oxygen atom;

[1185] [in particular such C3-6-cycloalkyl-L2- is oxetan-3-yl, cyclobutoxy-methyl, 1 -hydroxy-cyclopropyl, 1- hydroxy-cyclobutyl, 3-hydroxy-cyclobutyl, 1 -hydroxy-cyclopentyl, 3- hy d roxy-3-methy I -cy cl openty 1 , 1- hydroxy-cyclohexyl, 4-hydroxy-cyclohexyl, (1 -hydroxy-cyclohexyl)-methyl, (1 -hydroxy-cyclobutyl)-methyl, 1 -hydroxy-1 -cyclohexylmethyl, 1 -methoxy-cyclobutyl, 1 -methoxy-cyclopentyl, 1 -(1 -(methoxy-methyl)- cyclopropyl)-methyl, tetrahy d rof u ran-2-y l-methy I , tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, tetrahydropyran-3-yl, tetrahydropyran-4-yl, 4-methyl-tetrahydropyran-4-yl, 2,6-dimethyl-tetrahydropyran- 4-yl, 4-methoxy-tetrahydropyran-4-yl, 4-fl uoro-tetrahy d ropy ran-4-y I , tetrahyd ropy ran-4-y I -methyl , 2- (tetr ahy d ro py r an-4-y I )-ethy 1 , 1 - (tetrahyd ropy r an-4-y I )- 1-methyl-ethyl, tetrahydropyran-4-yl-oxy-methyl, or (4-methyl-tetrahydropyran-4-yl)-oxy-methyl]

[1186] > piperidin-4-yl which is N-substituted with Ci-3-alkyl-carbonyl (especially acetyl), (hydroxy-Ci-3-alkyl)- carbonyl (especially hydroxymethyl-carbonyl), or C3-5-cycloalkyl-sulfonyl;

[1187] [in particular such piperidin-4-yl is N-acety I -pi perid i n-4-y I , N-(hydroxymethyl-carbonyl)-piperidin-4-yl, or N- (cyclopropyl-sulfonyl)-piperidin-4-yl]

[1188] > morpholinyl-L3- (notably (morpholin-4-yl)-L3-), wherein -L3- represents a bond (i.e. the morpholinyl is directly attached to the rest of the molecule) or Ci.2-alkylene; wherein said morpholinyl is unsubstituted or di-substituted with methyl; [in particular such morpholinyl-L3- is morpholin-4-yl, morpholin-4-yl-methyl, or (2,6-dimethyl-morpholin-4- yl)-methyl]

[1189] > pyrazolyl-Ci-3-alkyl (especially 2-(pyrazol-1 -yl)-ethyl);

[1190] > Ci-3-alkyl-sulfonyl-Ci-3-alkyl (especially methyl-sulfonyl-methyl);

[1191] > 2,2,2-trifluoro-1 -hydroxy-1 -methyl-ethyl;

[1192] > 3-hydroxymethyl-bicyclo[1.1.1]pent-1 -yl;

[1193] > 7-oxa-bicyclo[2.2.1]hept-2-yl; and

[1194] > 6-oxa-spiro[2.5]oct-1-yl.

[1195] 44) Another embodiment of the present invention relates to compounds according to any one of embodiments 40) to 42), wherein A is mono-substituted in eia-position of A with respect to the point of attachment of A to the rest of the molecule, wherein the substituent of A is

[1196] > 5-membered heteroaryl containing from one to three (notably two or three; especially three) ring heteroatom(s) independently selected from nitrogen, oxygen and sulfur (notably pyrazolyl, triazolyl, oxazolyl, thiazolyl, oxadiazolyl; especially pyrazol-1-yl, 1,2,3-triazol-1-yl, oxazol-2-yl, thiazol-2-yl, 1,2,4-oxadiazol-5-yl or 1,2,4- oxadiazol-3-yl; most preferably 1,2,4-oxadiazol-5-yl or 1,2,4-oxadiazol-3-yl); wherein said 5-membered heteroaryl is independently unsubstituted, mono-, di-, or tri-substituted (notably mono-substituted; especially mono-substituted in position 3 with respect to the point of attachment of said 5-membered heteroaryl to A), wherein the substituent(s), if any, is(are) independently selected from

[1197] > amino-Ci-4-alkyl (especially 2-amino-ethyl or 2-amino-2, 2-dimethyl-ethyl), wherein the amino group is mono- or di-substituted (especially mono-substituted) with Ci_3-alkyl (especially methyl), Ci_3-alkyl- carbonyl including deuterated C i _3-al kyl-carbony I (especially acetyl or acetyl-2, 2, 2-d3), or hydroxy-Ci.3- alkyl-carbonyl (especially hydroxy-methyl-carbonyl);

[1198] [in particular such amino-C -alkyl is N-acetyl-2-amino-ethyl, N-(acetyl-2,2,2-d3)-2-amino-ethyl, N-acetyl- 2-amino-2, 2-dimethyl-ethyl, N-(acetyl-2, 2, 2-d3)-2-amino-2, 2-dimethyl-ethyl, N-methyl-N-(hydroxy-methyl- carbonyl)-2-amino-ethyl, N-methyl-N-acetyl-2-amino-ethyl, or N-methyl-N-(acetyl-2,2,2-d3)-2-amino-ethyl]

[1199] > piperidin-4-yl which is N-substituted with Ci-3-alkyl-carbonyl (especially acetyl), (hydroxy-Ci-3-alkyl)- carbonyl (especially hydroxymethyl-carbonyl), or C3-5-cycloalkyl-sulfonyl.

[1200] [in particular such piperidin-4-yl is N-acetyl-piperidin-4-yl, N-(hydroxymethyl-carbonyl)-piperidin-4-yl, or N- (cyclopropyl-sulfonyl)-piperidin-4-yl]

[1201] 45) Another embodiment of the present invention relates to compounds according to any one of embodiments 40) to 42), wherein A is mono-substituted in meia-position of A with respect to the point of attachment of A to the rest of the molecule, wherein the substituent is > 1 ,2,4-oxadiazol-3-yl which is mono-substituted, wherein the substituent is independently selected from

[1202] > amino-Ci-4-alkyl (especially 2-amino-ethyl or 2-amino-2, 2-dimethyl-ethyl), wherein the amino group is

[1203] ■mono-substituted with Ci_3-al kyl-carbonyl including deuterated Ci_3-alkyl-carbonyl (especially acetyl or acetyl-2,2,2-d3);

[1204] ■di-substituted, wherein a first substituent is Ci-3-alkyl (especially methyl) and a second substituent is Ci-3-alkyl-carbonyl (especially acetyl) or Ci-3-alkyl-carbonyl including deuterated Ci-3-alkyl-carbonyl (especially acetyl or acetyl-2,2,2-d3); or

[1205] ■di-substituted, wherein a first substituent is Ci-3-alkyl (especially methyl) and a second substituent is hydroxy-Ci-3-alkyl-carbonyl (especially hydroxy-methyl-carbonyl);

[1206] [in particular such amino-Ci_4-alkyl is N-acetyl-2-amino-ethyl, N-(acetyl-2,2,2-d3)-2-amino-ethyl, N-acetyl- 2-amino-2, 2-dimethyl-ethyl, N-(acetyl-2, 2, 2-d3)-2-amino-2, 2-dimethyl-ethyl, N-methyl-N-(hydroxy-methyl- carbonyl)-2-amino-ethyl, N-methyl-N-acetyl-2-amino-ethyl, or N-methyl-N-(acetyl-2,2,2-d3)-2-amino-ethyl]

[1207] > piperidin-4-yl which is N-substituted with Ci.3-alkyl-carbonyl (especially acetyl), (hydroxy-Ci.3-alkyl)- carbonyl (especially hydroxymethyl-carbonyl), or C3.5-cycloalkyl-sulfonyl.

[1208] [in particular such piperidin-4-yl is N-acetyl-piperidin-4-yl, N-(hydroxymethyl-carbonyl)-piperidin-4-yl, or N- (cyclopropyl-sulfonyl)-piperidin-4-yl]

[1209] 46) Another embodiment of the present invention relates to compounds according to any one of embodiments 40) or 42), wherein A represents pyridinyl (especially pyridin-3-yl) which is mono-substituted in eia-position with respect to the point of attachment of A to the rest of the molecule, wherein the substituent is oxadiazolyl (especially 1,2,4- oxadiazol-3-yl) which is mono-substituted, wherein the substituent is Ci_4-alkyl which is unsubstituted or mono- substituted with hydroxy or Ci_4-alkoxy (especially such Ci_4-alkyl is 1 -hydroxy-1 -methyl-ethyl, 2-hydroxy-2-methyl- propyl, or 2-hydroxy-1 , 1 -dimethyl-ethyl).

[1210] 47) Another embodiment of the present invention relates to compounds according to any one of embodiments 40) to 42), wherein A is mono-substituted in meia-position of A with respect to the point of attachment of A to the rest of the molecule, wherein the substituent of A is

[1211] > -CºC-RT1, wherein

[1212] > RT1represents

[1213] ■hydroxy-Ci-4-alkyl (especially hydroxy-methyl, 1 -hydroxy-ethyl, 2-hydroxy-ethyl, 1-hydroxy-2-methyl- propyl, or 1 -hydroxy-1 -methyl-ethyl);

[1214] ■Ci_3-alkoxy-Ci_3-alkyl (especially methoxy-methyl);

[1215] ■C3-6-cycloalkyl which is mono-substituted with hydroxy (notably at the point of attachment of the C3-6- cycloalkyl to the rest of the molecule; especially 1 -hydroxy-cyclopropyl, 1 -hydroxy-cyclobutyl, or 1- hydroxy-cyclopentyl);■C3-6-cycloalkyl (notably cyclopentyl or cyclohexyl) fused with a pyridine ring (notably at positions 2 and 3 of the pyridine ring), wherein said C3-6-cycloalkyl is mono-substituted with hydroxy (notably at position 1 of the C3-6-cycloalkyl ring) (especially 8-hydroxy-5,6,7,8-tetrahydroquinolin-8-yl or 7- hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl);

[1216] ■pyrazolyl (notably pyrazol-4-yl) which is mono- substituted with methyl (especially 1-methyl-pyrazol- 4-yl);

[1217] ■tetrahydropyranyl (especially tetrahydropyran-4-yl) which is unsubstituted or mono-substituted with hydroxy (especially 4-hydroxy-tetrahydropyran-4-yl);

[1218] ■indolyl (notably indol-2-yl); or

[1219] ■hydroxy-azetidinyl (notably 3-hydroxy-azetidin-3-yl) which is N-substituted with Ci.4-alkoxy-carbonyl (especially isopropyl-carbonyl or tert-butoxy-carbonyl);

[1220] [in particular such -CºC-RT1is 3-hydroxy-prop-1 -yn-1 -yl, 4-hydroxy-but-1 -yn-1 -yl, 3-hydroxy-but-1-yn-1-yl, 3- hydroxy-3-methyl-but-1 -yn-1 -yl, 3-hydroxy-4-methyl-pent-1-yn-1-yl, 3-methoxy-prop-1 -yn-1 -yl, (1-hydroxy- cyclopropyl)-ethynyl, (l-hydroxy-cyclobutyl)-ethynyl, (l-hydroxy-cyclopentyl)-ethynyl, (8-hy d roxy-5, 6,7,8- tetrahydroquinolin-8-yl)-ethynyl, (7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl)-ethynyl, (1-methyl- pyrazol-4-yl)-ethynyl, (tetrahydropyran-4-yl)-ethynyl, (4-hydroxy-tetrahydropyran-4-yl)-ethynyl, indol-2-yl- ethynyl, (1-(isopropyl-carbonyl)-3-hydroxy-azetidin-3-yl)-ethynyl, or (1-(tert-butoxy-carbonyl)-3-hydroxy- azetidin-3-yl)-ethynyl]

[1221] > -CºC-C(OH)(RT2)(RT3), wherein

[1222] > RT2represents hydrogen or Ci_3-alkyl (especially methyl or ethyl);

[1223] > RT3represents

[1224] ■phenyl which is unsubstituted or mono-substituted, wherein the substituent, if any, is selected from Ci-3-alkoxy (notably methoxy) or halogen (notably fluorine);

[1225] [in particular such group is 3-fluoro-phenyl, 4-methoxy-phenyl, or 2-methoxy-phenyl]

[1226] ■5- to 6-membered heteroaryl containing one or two ring heteroatom(s) being independently selected from nitrogen or sulfur (notably thiazolyl, pyrazolyl, pyridinyl, or pyrimidinyl; especially thiazol-4-yl, pyrazol-3-yl, pyrazol-4-yl, pyridin-2-yl, pyrimidin-2-yl, or pyrimidin-4-yl), wherein said 5- or 6- membered heteroaryl is independently unsubstituted, mono- or di- substituted, and wherein the substituent(s), if any, is(are) independently selected from Ci_3-alkyl (especially methyl) and Ci_3- alkoxy (especially methoxy); or [in particular such 5- to 6-membered heteroaryl group is 1 -methyl-pyrazol-3-yl, 1,3-dimethyl-pyrazol- 4-yl, 1,5-dimethyl-pyrazol-3-yl, 2-methyl-thiazol-4-yl, pyridin-2-yl, 6-methoxy-pyridin-2-yl, pyrimidin-2- yl, pyrimidin-4-yl, or 1,5-dimethyl-pyrazol-3-yl]

[1227] ■tetrahydropyranyl (especially tetrahydropyran-4-yl);

[1228] [in particular such -CºC-C(OH)(RT2)(RT3) is 3-hydroxy-3-(tetrahydropyran-4-yl)-prop-1-yn-1-yl, 3-hydroxy-3- phenyl-prop-1-yn-1-yl, 3-hydroxy-3-(2-methyl-thiazol-4-yl)-prop-1-yn-1-yl, 3-hy droxy-3-(1 , 3-d i methy l-pyrazol- 4-yl)-prop- 1 -y n- 1 -y 1 , 3-hydroxy-3-phenyl-but-1-yn-1-yl, 3-hydroxy-3-(1-methyl-pyrazol-3-yl)-but-1-yn-1-yl, 3- hydroxy-3-(1,5-dimethyl-pyrazol-3-yl)-but-1-yn-1-yl, 3-hydroxy-3-(1 -methyl-pyrazol-3-yl)-but-1 -yn-1 -yl, 3- hydroxy-3-(pyrimidin-2-yl)-but-1-yn-1-yl, 3-hydroxy-3-(1 -methyl-pyrazol-3-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(3- fluoro-phenyl)-but-1-yn-1-yl, 3-hydroxy-3-(6-methyl-pyrimidin-4-yl)-but-1 -yn-1 -yl, 3-hydroxy-3-(pyridin-2-yl)- pent-1-yn-1-yl, 3-hydroxy-3-(6-methoxy-pyridin-2-yl)-but-1-yn-1-yl, 3-hydroxy-3-(6-methoxy-pyridin-2-yl)-pent- 1-yn-1-yl, 3-hydroxy-3-(4-methoxy-phenyl)-but-1-yn-1-yl, or 3-hydroxy-3-(2-methoxy-phenyl)-but-1-yn-1-yl]

[1229] 48) Another embodiment of the present invention relates to compounds according to any one of embodiments 38) to 42), wherein A is mono-substituted in eia-position of A with respect to the point of attachment of A to the rest of the molecule, wherein the substituent of A is as defined in embodiment 42) or 46).

[1230] 49) Another embodiment of the present invention relates to compounds according to any one of embodiments 38) to

[1231] 48), wherein B represents phenyl, which is mono-substituted in para- position with respect to the point of attachment of B to the rest of molecule, wherein the substituent is selected from Ci-5-alkyl (especially ethyl, n-propyl, isopropyl, or tert- butyl; in particular isopropyl).

[1232] [in particular such B is 4-ethyl-phenyl, 4-propyl-phenyl, 4-isopropyl-phenyl, 4-tert-butyl-phenyl; in particular 4-isopropyl- phenyl]

[1233] 50) Another embodiment of the present invention relates to compounds according to any one of embodiments 38) to

[1234] 49), wherein R1represents Ci-3-alkyl (especially methyl).

[1235] 51) Another embodiment of the present invention relates to compounds according to any one of embodiments 38) to

[1236] 50), wherein R2represents Ci-4-alkyl (especially methyl, ethyl, n-propyl, isopropyl, tert-butyl or isobutyl).

[1237] 52) Another embodiment of the present invention relates to compounds according to embodiment 38), wherein

[1238] A represents pyridinyl (especially pyridin-3-yl) which is mono-substituted in meia-position with respect to the point of attachment of A to the rest of the molecule, wherein the substituent is oxadiazolyl (especially 1 ,2,4-oxadiazol-3-yl) which is mono-substituted, wherein the substituent is Ci_4-alkyl which is unsubstituted or mono-substituted with hydroxy or Ci_4-alkoxy (especially such Ci_4-alkyl which is unsubstituted or mono-substituted is 1 -hydroxy-1 -methyl-ethyl, 2- hydroxy-2-methyl-propyl, or 2-hydroxy-1 , 1 -dimethyl-ethyl); B represents phenyl which is mono-substituted in para- position with respect to the point of attachment of B to the rest of molecule, wherein the substituent is Ci_5-alkyl (especially isopropyl);

[1239] R1represents Ci_3-alkyl (especially methyl); and R2represents C -alkyl (especially methyl).

[1240] 53) Another embodiment relates to compounds according to any one of embodiments 38) to 52), which are also compounds of Formula (lip) (i.e. the asymmetric carbon atom to which A and B are attached has the absolute configuration depicted in Formula (lip))

[1241] Formula (lip)

[1242] It is understood that for A being pyridin-3-yl, pyrimidin-5-yl, pyrazin-2-yl, or pyridazin-4-yl (especially pyridin-3-yl), the asymmetric carbon atom to which A and B are attached, as depicted in Formula (lip), has absolute configuration (R). In the case where A represents pyridin-4-yl, the asymmetric carbon atom to which A and B are attached, as depicted in Formula (II), has absolute configuration (S).

[1243] Based on the dependencies of the different embodiments 1) to 37) as disclosed hereinabove, the following embodiments are thus possible and intended, and herewith specifically disclosed in individualized form:

[1244] 2+1, 3+1, 4+1, 11+1, 11+2+1, 11+3+1, 11+4+1, 12+11+1, 12+11+2+1, 12+11+3+1, 12+11+4+1, 13+11+1, 13+11+2+1, 13+11+3+1, 13+11+4+1, 14+11+1, 14+11+2+1, 14+11+3+1, 14+11+4+1, 15+11+1, 15+11+2+1, 15+11+3+1, 15+11+4+1, 16+1, 16+2+1, 16+3+1, 16+4+1, 17+16+1, 17+16+2+1, 17+16+3+1, 17+16+4+1, 18+16+1, 18+16+2+1, 18+16+3+1, 18+16+4+1, 19+16+1, 19+16+2+1, 19+16+3+1, 19+16+4+1, 20+1, 20+2+1, 20+3+1, 20+4+1, 21+20+1, 21+20+2+1, 21+20+3+1, 21+20+4+1, 22+20+1, 22+20+2+1, 22+20+3+1 , 22+20+4+1 , 23+1, 23+2+1, 23+3+1, 23+4+1, 23+5, 23+6, 23+7, 23+8, 23+9, 23+10, 23+11+1, 23+11+2+1, 23+11+3+1, 23+11+4+1, 23+12+11+1, 23+12+11+2+1, 23+12+11+3+1, 23+12+11+4+1, 23+13+11+1, 23+13+11+2+1, 23+13+11+3+1, 23+13+11+4+1, 23+14+11+1, 23+14+11+2+1, 23+14+11+3+1, 23+14+11+4+1, 23+15+11+1, 23+15+11+2+1, 23+15+11+3+1, 23+15+11+4+1, 23+16+1, 23+16+2+1, 23+16+3+1, 23+16+4+1, 23+17+16+1, 23+17+16+2+1, 23+17+16+3+1, 23+17+16+4+1, 23+18+16+1, 23+18+16+2+1, 23+18+16+3+1, 23+18+16+4+1, 23+19+16+1, 23+19+16+2+1, 23+19+16+3+1, 23+19+16+4+1, 23+20+1, 23+20+2+1, 23+20+3+1, 23+20+4+1, 23+21+20+1, 23+21+20+2+1, 23+21+20+3+1, 23+21+20+4+1, 23+22+20+1, 23+22+20+2+1, 23+22+20+3+1, 23+22+20+4+1, 26+1, 26+2+1, 26+3+1, 26+4+1, 26+5, 26+6, 26+7, 26+8, 26+9, 26+10, 26+11+1, 26+11+2+1, 26+11+3+1, 26+11+4+1, 26+12+11+1, 26+12+11+2+1, 26+12+11+3+1, 26+12+11+4+1, 26+13+11+1, 26+13+11+2+1, 26+13+11+3+1, 26+13+11+4+1, 26+14+11+1, 26+14+11+2+1, 26+14+11+3+1, 26+14+11+4+1, 26+15+11+1, 26+15+11+2+1, 26+15+11+3+1, 26+15+11+4+1, 26+16+1, 26+16+2+1, 26+16+3+1, 26+16+4+1, 26+17+16+1, 26+17+16+2+1, 26+17+16+3+1, 26+17+16+4+1, 26+18+16+1, 26+18+16+2+1, 26+18+16+3+1, 26+18+16+4+1, 26+19+16+1, 26+19+16+2+1, 26+19+16+3+1, 26+19+16+4+1, 26+20+1, 26+20+2+1, 26+20+3+1, 26+20+4+1, 26+21+20+1, 26+21+20+2+1, 26+21+20+3+1, 26+21+20+4+1, 26+22+20+1, 26+22+20+2+1, 26+22+20+3+1, 26+22+20+4+1, 26+23+1, 26+23+2+1, 26+23+3+1, 26+23+4+1, 26+23+5, 26+23+6, 26+23+7, 26+23+8, 26+23+9, 26+23+10, 26+23+11+1, 26+23+11+2+1, 26+23+11+3+1, 26+23+11+4+1, 26+23+12+11+1, 26+23+12+11+2+1, 26+23+12+11+3+1, 26+23+12+11+4+1, 26+23+13+11+1, 26+23+13+11+2+1, 26+23+13+11+3+1, 26+23+13+11+4+1, 26+23+14+11+1, 26+23+14+11+2+1, 26+23+14+11+3+1, 26+23+14+11+4+1, 26+23+15+11+1, 26+23+15+11+2+1, 26+23+15+11+3+1, 26+23+15+11+4+1, 26+23+16+1, 26+23+16+2+1, 26+23+16+3+1, 26+23+16+4+1, 26+23+17+16+1, 26+23+17+16+2+1, 26+23+17+16+3+1, 26+23+17+16+4+1, 26+23+18+16+1, 26+23+18+16+2+1, 26+23+18+16+3+1, 26+23+18+16+4+1, 26+23+19+16+1, 26+23+19+16+2+1, 26+23+19+16+3+1, 26+23+19+16+4+1, 26+23+20+1, 26+23+20+2+1, 26+23+20+3+1, 26+23+20+4+1, 26+23+21+20+1, 26+23+21+20+2+1, 26+23+21+20+3+1, 26+23+21+20+4+1, 26+23+22+20+1, 26+23+22+20+2+1, 26+23+22+20+3+1, 26+23+22+20+4+1, 26+24, 26+25, 28+1, 28+2+1, 28+3+1, 28+4+1, 28+5, 28+6, 28+7, 28+8, 28+9, 28+10, 28+11+1, 28+11+2+1, 28+11+3+1, 28+11+4+1, 28+12+11+1, 28+12+11+2+1, 28+12+11+3+1, 28+12+11+4+1, 28+13+11+1, 28+13+11+2+1, 28+13+11+3+1, 28+13+11+4+1, 28+14+11+1, 28+14+11+2+1, 28+14+11+3+1, 28+14+11+4+1, 28+15+11+1, 28+15+11+2+1, 28+15+11+3+1, 28+15+11+4+1, 28+16+1, 28+16+2+1, 28+16+3+1, 28+16+4+1, 28+17+16+1, 28+17+16+2+1, 28+17+16+3+1, 28+17+16+4+1, 28+18+16+1, 28+18+16+2+1, 28+18+16+3+1, 28+18+16+4+1, 28+19+16+1, 28+19+16+2+1, 28+19+16+3+1, 28+19+16+4+1, 28+20+1, 28+20+2+1, 28+20+3+1, 28+20+4+1, 28+21+20+1, 28+21+20+2+1, 28+21+20+3+1, 28+21+20+4+1, 28+22+20+1, 28+22+20+2+1, 28+22+20+3+1, 28+22+20+4+1, 28+23+1, 28+23+2+1, 28+23+3+1, 28+23+4+1, 28+23+5, 28+23+6, 28+23+7, 28+23+8, 28+23+9, 28+23+10, 28+23+11+1, 28+23+11+2+1, 28+23+11+3+1, 28+23+11+4+1, 28+23+12+11+1, 28+23+12+11+2+1, 28+23+12+11+3+1, 28+23+12+11+4+1, 28+23+13+11+1, 28+23+13+11+2+1, 28+23+13+11+3+1, 28+23+13+11+4+1, 28+23+14+11+1, 28+23+14+11+2+1, 28+23+14+11+3+1, 28+23+14+11+4+1, 28+23+15+11+1, 28+23+15+11+2+1, 28+23+15+11+3+1, 28+23+15+11+4+1, 28+23+16+1, 28+23+16+2+1, 28+23+16+3+1, 28+23+16+4+1, 28+23+17+16+1, 28+23+17+16+2+1, 28+23+17+16+3+1, 28+23+17+16+4+1, 28+23+18+16+1, 28+23+18+16+2+1, 28+23+18+16+3+1, 28+23+18+16+4+1, 28+23+19+16+1, 28+23+19+16+2+1, 28+23+19+16+3+1, 28+23+19+16+4+1, 28+23+20+1, 28+23+20+2+1, 28+23+20+3+1, 28+23+20+4+1, 28+23+21+20+1, 28+23+21+20+2+1, 28+23+21+20+3+1, 28+23+21+20+4+1, 28+23+22+20+1, 28+23+22+20+2+1, 28+23+22+20+3+1, 28+23+22+20+4+1, 28+24, 28+25, 28+26+1, 28+26+2+1, 28+26+3+1, 28+26+4+1, 28+26+5, 28+26+6, 28+26+7, 28+26+8, 28+26+9, 28+26+10, 28+26+11+1, 28+26+11+2+1, 28+26+11+3+1, 28+26+11+4+1, 28+26+12+11+1, 28+26+12+11+2+1, 28+26+12+11+3+1, 28+26+12+11+4+1, 28+26+13+11+1, 28+26+13+11+2+1, 28+26+13+11+3+1, 28+26+13+11+4+1, 28+26+14+11+1, 28+26+14+11+2+1, 28+26+14+11+3+1, 28+26+14+11+4+1, 28+26+15+11+1, 28+26+15+11+2+1, 28+26+15+11+3+1, 28+26+15+11+4+1, 28+26+16+1, 28+26+16+2+1, 28+26+16+3+1, 28+26+16+4+1, 28+26+17+16+1, 28+26+17+16+2+1, 28+26+17+16+3+1, 28+26+17+16+4+1, 28+26+18+16+1, 28+26+18+16+2+1, 28+26+18+16+3+1, 28+26+18+16+4+1, 28+26+19+16+1, 28+26+19+16+2+1, 28+26+19+16+3+1, 28+26+19+16+4+1, 28+26+20+1, 28+26+20+2+1, 28+26+20+3+1, 28+26+20+4+1, 28+26+21+20+1, 28+26+21+20+2+1, 28+26+21+20+3+1, 28+26+21+20+4+1, 28+26+22+20+1, 28+26+22+20+2+1, 28+26+22+20+3+1, 28+26+22+20+4+1, 28+26+23+1, 28+26+23+2+1, 28+26+23+3+1, 28+26+23+4+1, 28+26+23+5, 28+26+23+6, 28+26+23+7, 28+26+23+8, 28+26+23+9, 28+26+23+10, 28+26+23+11+1, 28+26+23+11+2+1, 28+26+23+11+3+1, 28+26+23+11+4+1, 28+26+23+12+11+1, 28+26+23+12+11+2+1, 28+26+23+12+11+3+1, 28+26+23+12+11+4+1, 28+26+23+13+11+1, 28+26+23+13+11+2+1, 28+26+23+13+11+3+1, 28+26+23+13+11+4+1, 28+26+23+14+11+1, 28+26+23+14+11+2+1, 28+26+23+14+11+3+1, 28+26+23+14+11+4+1, 28+26+23+15+11+1, 28+26+23+15+11+2+1, 28+26+23+15+11+3+1, 28+26+23+15+11+4+1, 28+26+23+16+1, 28+26+23+16+2+1, 28+26+23+16+3+1, 28+26+23+16+4+1, 28+26+23+17+16+1, 28+26+23+17+16+2+1, 28+26+23+17+16+3+1, 28+26+23+17+16+4+1, 28+26+23+18+16+1, 28+26+23+18+16+2+1, 28+26+23+18+16+3+1,

[1245] 28+26+23+18+16+4+1, 28+26+23+19+16+1, 28+26+23+19+16+2+1, 28+26+23+19+16+3+1, 28+26+23+19+16+4+1,

[1246] 28+26+23+20+1, 28+26+23+20+2+1, 28+26+23+20+3+1, 28+26+23+20+4+1, 28+26+23+21+20+1, 28+26+23+21+20+2+1, 28+26+23+21+20+3+1, 28+26+23+21+20+4+1, 28+26+23+22+20+1, 28+26+23+22+20+2+1, 28+26+23+22+20+3+1,

[1247] 28+26+23+22+20+4+1, or 28+26+24, 28+26+25.

[1248] The invention relates to compounds of the Formula (I) as defined in embodiment 1), or to such compounds further limited by the characteristics of any one of embodiments 2) to 53), under consideration of their respective dependencies; to pharmaceutically acceptable salts thereof; and to the use of such compounds as medicaments especially in the treatment of diseases or disorders where CCR6 receptors are involved as described hereinbelow.

[1249] The present invention also includes isotopically labelled, especially2H (deuterium) labelled compounds of Formula (I), which compounds are identical to the compounds of Formula (I) except that one or more atoms have each been replaced by an atom having the same atomic number but an atomic mass different from the atomic mass usually found in nature. Isotopically labelled, especially2FI (deuterium) labelled compounds of Formula (I) and salts thereof are within the scope of the present invention. Substitution of hydrogen with the heavier isotope2FI (deuterium) may lead to greater metabolic stability, resulting e.g. in increased in-vivo half-life or reduced dosage requirements, or may lead to reduced inhibition of cytochrome P450 enzymes, resulting e.g. in an improved safety profile. In one embodiment of the invention, the compounds of Formula (I) are not isotopically labelled, or they are labelled only with one or more deuterium atoms. In a sub-embodiment, the compounds of Formula (I) are not isotopically labelled at all. Isotopically labelled compounds of Formula (I) may be prepared in analogy to the methods described hereinafter, but using the appropriate isotopic variation of suitable reagents or starting materials.

[1250] Where the plural form is used for compounds, salts, pharmaceutical compositions, diseases and the like, this is intended to mean also a single compound, salt, pharmaceutical composition, disease or the like.

[1251] Any reference to compounds of Formula (I) according to embodiments 1) to 53) is to be understood as referring also to the salts (and especially the pharmaceutically acceptable salts) of such compounds, as appropriate and expedient.

[1252] The term "pharmaceutically acceptable salts" refers to salts that retain the desired biological activity of the subject compound and exhibit minimal undesired toxicological effects. Such salts include inorganic or organic acid and / or base addition salts depending on the presence of basic and / or acidic groups in the subject compound. For reference see for example "Flandbook of Pharmaceutical Salts. Properties, Selection and Use.”, P. Heinrich Stahl, Camille G. Wermuth (Eds.), Wiley-VCH, 2008; and "Pharmaceutical Salts and Co-crystals”, Johan Wouters and Luc Quere (Eds.), RSC Publishing, 2012.

[1253] Definitions provided herein are intended to apply uniformly to the compounds of Formula (I), as defined in any one of embodiments 1) to 53), and, mutatis mutandis, throughout the description and the claims unless an otherwise expressly set out definition provides a broader or narrower definition. It is well understood that a definition or preferred definition of a term defines and may replace the respective term independently of (and in combination with) any definition or preferred definition of any or all other terms as defined herein.

[1254] The compounds of Formula (I) may encompass compounds with one or more asymmetric centers, such as one or more asymmetric carbon atoms, which may be present in (R)- as well as (S)-configuration. The compounds of Formula (I) may further encompass compounds with one or more double bonds which are allowed to be present in Z- as well as E- configuration and / or compounds with substituents at a ring system which are allowed to be present, relative to each other, in cis- as well as trans-configuration. The compounds of Formula (I) may thus be present as mixtures of stereoisomers or preferably in stereoisomerically enriched form, especially as essentially pure stereoisomers. Mixtures of stereoisomers may be separated in a manner known to a person skilled in the art.

[1255] In case a particular compound (or generic structure) is designated as (R)- or (S)-enantiomer, such designation is to be understood as referring to the respective compound (or generic structure) in enriched, especially essentially pure, enantiomeric form. Likewise, in case a specific asymmetric center in a compound is designated as being in (R)- or (S)- configuration or as being in a certain relative configuration, such designation is to be understood as referring to the compound that is in enriched, especially essentially pure, form with regard to the respective configuration of said asymmetric center. In analogy, cis- or trans-designations are to be understood as referring to the respective stereoisomer in enriched, especially essentially pure, form. Likewise, in case a particular compound (or generic structure) is designated as Z- or E-stereoisomer (or in case a specific double bond in a compound is designated as being in Z- or E-configuration), such designation is to be understood as referring to the respective compound (or generic structure) in enriched, especially essentially pure, stereoisomeric form (or to the compound that is in enriched, especially essentially pure, form with regard to the respective configuration of the double bond).

[1256] The term "enriched", when used in the context of stereoisomers, is to be understood in the context of the present invention to mean that the respective stereoisomer is present in a ratio of at least 70:30, especially of at least 90:10 (i.e., in a purity of at least 70% by weight, especially of at least 90% by weight), with regard to the respective other stereoisomer / the entirety of the respective other stereoisomers.

[1257] The term "essentially pure”, when used in the context of stereoisomers, is to be understood in the context of the present invention to mean that the respective stereoisomer is present in a purity of at least 95% by weight, especially of at least 99% by weight, with regard to the respective other stereoisomer / the entirety of the respective other stereoisomers.

[1258] The compounds of Formula (I) according to embodiments 1) to 53) and their pharmaceutically acceptable salts can be used as medicaments, e.g. in the form of pharmaceutical compositions for enteral (such especially oral) or parenteral administration (including topical application or inhalation).

[1259] The production of the pharmaceutical compositions can be effected in a manner which will be familiar to any person skilled in the art (see for example Remington, The Science and Practice of Pharmacy, 21st Edition (2005), Part 5, "Pharmaceutical Manufacturing” [published by Lippincott Williams & Wilkins]) by bringing the described compounds of Formula (I), or their pharmaceutically acceptable salts, optionally in combination with other therapeutically valuable substances, into a galenical administration form together with suitable, non-toxic, inert, therapeutically compatible solid or liquid carrier materials and, if desired, usual pharmaceutical adjuvants.

[1260] Whenever the word "between” is used to describe a numerical range, it is to be understood that the end points of the indicated range are explicitly included in the range. For example: if a temperature range is described to be between 40 °C and 80 °C, this means that the end points 40 °C and 80 °C are included in the range; or if a variable is defined as being an integer between 1 and 4, this means that the variable is the integer 1, 2, 3, or 4.

[1261] Unless used regarding temperatures, the term "about” (or alternatively the term "around”) placed before a numerical value "X” refers in the current application to an interval extending from X minus 10% of X to X plus 10% of X, and preferably to an interval extending from X minus 5% of X to X plus 5% of X. In the particular case of temperatures, the term "about” placed before a temperature “Y" refers in the current application to an interval extending from the temperature Y minus 10 °C to Y plus 10 °C, and preferably to an interval extending from Y minus 5 °C to Y plus 5 °C.

[1262] Th...

Claims

CLAIMS1. A compound according to Formula (I),whereinA represents a 6-membered heteroaryl containing from one to three ring nitrogen atom(s), wherein said 6-membered heteroaryl is independently unsubstituted, mono-, di- or tri-substituted, wherein the substituent(s), if any, is(are) independently selected from• halogen;• cyano;• hydroxy-Ci-6-alkyl which is optionally further substituted with one to three fluorine atoms;• Ci-5-alkyl which is unsubstituted or mono-substituted with> Ci_3-alkoxy;> C3-6-cycloalkyl which is optionally fused with a pyridine ring, wherein said C3-6-cycloalkyl is unsubstituted or mono-substituted with hydroxy;> -O-R01, wherein R01represents C3-6-cycloalkyl or pyrrolidinyl which is independently unsubstituted or mono-substituted with Ci-3-alkyl or Ci-4-alkyl-carbonyl;> phenyl— L1—, wherein said phenyl is unsubstituted or mono-substituted with fluorine, C -alkoxy- carbonyl, or hydroxy-C -alkyl; wherein -L1- represents a bond, oxygen, or the group -CH2-O-;> C4-6-heterocyclyl containing one or two ring heteroatoms independently selected from nitrogen and oxygen, wherein said C4-6-heterocyclyl is unsubstituted, mono-, or di-substituted with oxo, hydroxy, Ci-3-alkyl, C -alkyl-carbonyl, or C1_4- al koxy-carbony I ;> 5-membered heteroaryl containing one or two ring nitrogen atoms, wherein said 5-membered heteroaryl is unsubstituted or mono-substituted with Ci-3-alkyl;> -NRN1RN1wherein RN1represents hydrogen and RN2represents Ci-3-alkyl-carbonyl or hydroxy-Ci-3- alkyl-carbonyl;> indolyl;> pyrrolopyridinyl;> N-(Ci-3-alkyl)-amino-carbonyl-oxy; or> 1 -hydroxy-1- C3_5-cycloalkyl-1-(pyridinyl)-methyl;• C3-5-alkyl which is substituted with hydroxy and RA1, wherein said substituents are both at position 3 with respect to the point of attachment of said C3-s-alkyl to the rest of the molecule; wherein> RA1represents■tetrahydropyranyl;■phenyl which is unsubstituted or mono-substituted with fluorine or Ci_3-alkoxy;■5- or 6-membered heteroaryl containing one or two ring heteroatom(s) being independently selected from nitrogen or sulfur, wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono- or di- substituted, and wherein the substituent(s), if any, is(are) independently selected from Ci-3-alkyl, C3-5-cycloalkyl, or Ci_3-alkoxy; or■indolyl;■pyrrolopyridinyl;• C3-5-alkenyl which is unsubstituted or mono-substituted with hydroxy;• C4-6-cy cloal keny I which is unsubstituted, mono-, or di-substituted with Ci_3-alkyl, oxo, or hydroxy, wherein optionally one ring carbon atom of said C4-6-cycloalkenyl is replaced by an oxygen atom;> C3-6-cycloalkyl which is unsubstituted, mono-, or di-substituted with Ci_3-alkyl, hydroxy or hy droxy-Ci _3-al ky I , wherein optionally one ring carbon atom of said C3-6-cycloalkyl is replaced by an oxygen atom;> -O-R02, wherein> R02represents■Ci-4-alkyl;■C2-5-alkyl which is mono-substituted with hydroxy or Ci_3-alkoxy;■-L2-CY2, wherein❖ -L2- independently represents a bond, -CH2-, or -CH2-CH2-; and❖ CY2independently represents o phenyl which is unsubstituted or mono-substituted with hydroxy-Ci_3-alkyl; o benzyl-oxy; o 5- to 6-membered heteroaryl containing one to three ring heteroatom(s) being independently selected from nitrogen, oxygen, or sulfur, wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono- or di- substituted; wherein the substituent(s), if any, is(are) independently selected from Ci_3-alkyl or Ci-3-cycloalkyl; o C3-6-cycloalkyl, wherein optionally one carbon ring atom is replaced by one heteroatom selected from oxygen and nitrogen; wherein said C3-6- cycloalkyl is unsubstituted, mono-, or di-substituted, wherein thesubstituents are selected from Cu-alkyl, hydroxy, fluoro, oxo, Ci-3-alkyl- carbonyl and Ci_3-alkoxy; o benzooxazolonyl; o chromanyl;• -CºC-RT1, wherein> RT1represents■Ci-4-alkyl, wherein said C -alkyl independently is mono-substituted with❖ hydroxy;❖ Ci-3-alkoxy;❖ -S(=0)2-Rsot, wherein RS0Trepresents Cu-alkyl, Ci-3-alkyl-amino, or C3-5- cycloalkyl;❖ -NRNT1RNT2wherein RNT1represents hydrogen and RNT2represents Ci_3-alkyl- carbonyl, C1_3- al koxy-C1.3-al ky l-car bony I , or C3-5-cycloalkyl-carbonyl;❖ C4-6-heterocyclyl containing one or two ring heteroatom(s) independently selected from nitrogen and oxygen; wherein said C4-6-heterocyclyl is mono-substituted with oxo; or di-substituted with oxo and one Ci-3-alkyl; or❖ N-(Ci-3-alkyl-carbonyl)-piperidinyl-Ci-3-alkyl;■Ci-4-alkyl which is di-substituted, wherein one substituent is hydroxy, and a second substituent is trifluoromethyl;■C3-6-cycloalkyl which is mono-substituted with❖ hydroxy;❖ amino-sulfonyl which is optionally di-substituted with methyl;❖ phenyl which is mono-substituted with halogen;❖ pyridinyl;❖ pyrimidinyl which is mono-substituted with Ci-3-alkyl; or❖ oxazolidinonyl;■C3-6-cycloalkyl fused with a pyridine ring, wherein said C3-6-cycloalkyl is mono-substituted with hydroxy ; wherein optionally one ring carbon atom in said C3-6-cycloalkyl is replaced by one oxygen atom;■C4-6-heterocyclyl containing one ring heteroatom independently selected from nitrogen and oxygen; wherein said C4-6-heterocyclyl is mono-, di-, or tri-substituted, wherein the substituent(s) is(are) independently selected from Ci-3-alkyl, hydroxy, oxo, Ci-3-alkyl- carbonyl, C1-3-al koxy-carbony I , Ci-3-alkyl-sulfonyl, and C1-3-al ky I -ami no-su Ifony I ;■pyrazolyl which is N-substituted with methyl;■indolyl;■3-hydroxy-1 -methyl-1, 3-d i hy d ro-i ndol-2-on-3-y I ; or■4-hydroxy-3,4-dihydro-2H-pyrano[3,2-b] pyridin-4-yl;• -CºC-C(OH)(RT2)(RT3), wherein> RT2represents hydrogen or Ci-3-alkyl;> RT3represents■phenyl which is unsubstituted or mono-substituted, wherein the substituent, if any, is selected from Ci-3-alkoxy and halogen;■5- to 6-membered heteroaryl containing one or two ring heteroatom(s) being independently selected from nitrogen, oxygen, or sulfur; wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono- or di- substituted, and wherein the substituent(s), if any, is(are) independently selected from Ci_3-alkyl, Ci_3-cycloalkyl, Ci_3-fluoroalkyl, and Ci_3- alkoxy;■C4-7-heterocyclyl containing one ring heteroatom selected from nitrogen and oxygen; wherein said C4-7-heterocyclyl is unsubstituted, mono-, or di-substituted, wherein the substituent(s), if any, is(are) independently selected from Ci-3-alkyl or Ci-3-alkyl-carbonyl; or■indazolyl;• -NRN3RN4wherein> RN3represents Ci-3-alkyl; andRN4represents hydroxy-Ci-3-alkyl or 2-(benzyl-oxy)-Ci-3-alkyl; or> RN3and RN4form, together with the nitrogen to which they are attached, a heterocyclic ring of 4 to 6 members, wherein the members needed to complete said heterocyclic ring are each independently selected from -CH2-, -0-, -(C=0)-, -CHRX- and -C(RY)2-; wherein said heterocyclic ring does not contain more than one member independently selected from the group consisting of -0- and -(C=0)- ; wherein said heterocyclic ring does not contain more than two members selected from the group consisting of -CHRX-; and wherein said heterocyclic ring does not contain more than two members selected from the group consisting of -C(RY)2-; wherein Rxindependently represents fluorine, methyl, isopropyl, isobutyl, tert-butyl, hydroxy, trifluoromethyl, hydroxy-methyl, 1 -hydroxy-ethyl, 1-hydroxy-1- methyl-ethyl, cyclopropyl, 2-methoxy-ethyl, 2-methyl-thiazol-5-yl, 4-methyl-thiazol-2-yl, phenyl, benzyl, tetrahydropyran-4-yl, N-acetyl-piperidin-4-yl, 1,2,4-oxadiazolyl, 3-methyl-1,2,4-oxadiazol-5- yl, 2-methyl-2H-[1,2,3]triazol-4-yl, 1 -methyl-1 H-pyrazol-4-yl, 1 -difluoromethyl-1 H-pyrazol-4-yl, 1,3- dimethyl-1 H-pyrazol-4-yl, pyridin-2-yl, 6-methyl-pyridin-3-yl, 6-isopropyl-pyridin-2-yl, 6- trifl uoromethy l-py ri di n-3-yl , 2-isopropyl-pyrimidin-4-yl, or 1-methoxy-methyl; and wherein RYindependently represents fluorine, hydroxy, cyclopropyl, methyl, hydroxy-methyl, or trifluoromethyl;• -(C=0)-N(RN5)(RN6), wherein> RN5represents hydrogen; andRN6represents C3-6-cycloal kyl or tetrahydropyranyl; or> RN5and RN6form, together with the nitrogen to which they are attached, pyrrolidinyl;> piperidin-4-yl or pyrrolidin-3-yl which are mono-substituted at the nitrogen ring atom, wherein the substituent independently is selected from C1-4- al koxy-car bony I , pyridinyl, phenyl, and 4-methylphenyl-sulfonyl;> 5- or 6-membered heteroaryl containing from one to three ring heteroatom(s) independently selected from nitrogen, oxygen and sulfur; wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono- , di-, or tri-substituted, wherein the substituent(s), if any, is(are) independently selected from> Ci-4-alkyl which is■unsubstituted; or■mono-substituted with❖ hydroxy;❖ Ci-4-alkoxy; or❖ -N(RN7)(RN8), wherein RN7represents hydrogen or Ci-3-alkyl; and RN8independently represent C3-5-cycloalkyl-carbonyl, Ci-3-al kyl, Ci-3-alkyl-carbonyl including deuterated Ci-3-alkyl-carbonyl, Ci-3-alkoxy-Ci-3-alkyl-carbonyl, tetrahydropyranyl-carbonyl, or hy d roxy-C1-3-al kyl -carbonyl ;■di-substituted, wherein one substituent is hydroxy, and another substituent is trifluoromethyl; or two substituents are hydroxy;■di- or tri-substituted, wherein two substituents are fluorine and, if present, one substituent is hydroxy;> -L3-CY3, wherein■-L3- independently represents a bond, -CH2-, -CH2-CH2-, -C(CH3)2-, -CH(OH)-, or -O-CH2- , wherein when -L3- is -O-CH2-, said CY3is attached to the oxygen atom of said -O-CH2-; and■CY3independently represents C3-6-cycloalkyl or C4-6-heterocyclyl, said C4-6-heterocyclyl containing one or two ring heteroatoms independently selected from nitrogen and oxygen; wherein said CY3independently is unsubstituted, mono-, di-, or tri-substituted, wherein the substituents are independently selected from> halogen;> oxo;> hydroxy;> Ci-3-alkyl which is optionally mono-substituted with Ci-3-alkoxy;> Ci-3-alkoxy;> -(C=0)-Rco, wherein Rcorepresents o Ci_3-alkyl which is optionally mono-substituted with hydroxy or Ci_3-alkoxy; o Ci-3-fluoroalkyl; o Ci-3-alkoxy, wherein said Ci-3-alkoxy is optionally mono-substituted with Ci-3-alkoxy; o C3-6-cycloalkyl-(CH2)n-, wherein optionally one or two carbon ring atom(s) is / are replaced by one or two oxygen ring atom(s); wherein n represents the integer 0, 1, or 2; or o phenyl;> -N(RN9)(RN10), wherein RN9represents hydrogen or Ci_3-alkyl; and RN1° represents Ci-3-alkyl, Ci_3-alkyl-carbonyl, Ci-3-alkyl-sulfonyl, Ci.3-alkoxy-carbonyl, Ci.3-alkoxy- Ci-3-alkyl-carbonyl, or tetrahydropyranyl-carbonyl;> -S(=0)2-Rso, wherein Rsorepresents o Ci-3-alkyl which is optionally mono-substituted with hydroxy, Ci-3-alkoxy, or amino; or o C3-5-cycloalkyl, wherein optionally one carbon ring atom is replaced by one oxygen ring atom;> 5-membered heteroaryl containing one ring heteroatom selected from nitrogen, oxygen, and sulfur; wherein said 5-membered heteroaryl is unsubstituted; and> phenyl-(CH2)p-, wherein p represents the integer 0, 1, or 2;> phenyl or 6-membered heteroaryl containing one or two ring nitrogen atom(s); wherein said phenyl or 6-membered heteroaryl is independently unsubstituted or mono-substituted with Ci-3-alkyl or C1-3- alkoxy;> pyrazolyl-Ci-3-alkyl;> Ci-3-alkyl-sulfonyl-Ci-3-alkyl;> 3-hydroxymethyl-bicyclo[1.1.1]pent-1 -yl;> 7-oxa-bicyclo[2.2.1]hept-2-yl; and> 6-oxa-sp i ro [2.5] oct- 1 -y I ;• 5-oxo-4-oxa-6-azaspiro[2.4]hept-6-yl, 5-aza-spiro[2.4]heptan-6-on-5yl, 2,2-dimethyl-6-oxo-5-oxa-7- azaspiro[3.4]oct-7-yl, 2-cyclopropyl-6-oxo-5-oxa-7-azaspiro[3.4]oct-7-yl, 2-oxo-1-oxa-3-azaspiro[4.4]non-3-yl, 8,8-difluoro-2-oxo-1-oxa-3-azaspiro[4.5]dec-3-yl, or 8-oxo-7-oxa-9-azadispiro[3.1.4.1]undec-9-yl;• 7-aza-bicyclo[2.2.1]hept-7-yl, 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl, 6-oxa-3-aza-bicyclo[3.1.1]hept-3-yl, or 8- oxa-3-azabicyclo[3.2.1]oct-3-yl;• 5-oxo-6-azaspiro[3.4]oct-6-yl, 3-oxo-2-azaspiro[4.4]non-2-yl, 1-oxa-3-aza-spiro[4.5]decan-2-on-3-yl, 1-oxo-2- azaspiro[4.5]dec-2-yl, 1-oxo-8-oxa-2-azaspiro[4.5]dec-2-yl, 3-oxo-8-oxa-2-azaspiro[4.5]dec-2-yl, or 4-oxo- h exahy d ro-5 H -f u ro [2 , 3-c] py r ro I -5-y I ;• 3-(7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl)propyl or 3-(8-hydroxy-5,6,7,8-tetrahydroquinolin-8- yl)propyl);• 6-acetyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl;• 6-acetyl-5,6,7,8-tetrahydro-1 ,6-naphthyridine-2-yl;• 2-(6,7-dihydro-5H-[1]pyrindin-7-ol)-ethyl;• 2-(8-hydroxy-5,6,7,8-tetrahydro-quinolin-8-yl)-ethyl;• 7,8-dihydro-5H-[1 ,6]naphthyridin-6-yl;• 2,3-dihydro-isoindol-1 -on-2-yl;• 7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl; and• 6-acetyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl;B represents phenyl, which is unsubstituted, mono-, di- or tri-substituted, wherein a first substituent, if present, is selected from> halogen;> Ci-5-alkyl;> C2-4-alkenyl;> Ci-3-alkoxy;> Ci-3-alkoxy-Ci-4-alkyl;> Ci-4-fluoroalkyl;> C3-5-cycloalkyl which independently is unsubstituted or mono-substituted with Ci_3-alkyl or Ci_3-fluoroalkyl;> -SF5;> bicyclo[1.1.1]pent-1-yl;> C3-5-cycloalkoxy; and> Ci-3-fluoroalkoxy; and the remaining substituent / s of B, if present, independently is / are selected from halogen and Ci_3-alkyl; or B represents benzothiophenyl or naphthalenyl;R1represents Ci-3-alkyl, cyano, or halogen; andR2represents C -alkyl, C3-5-cycloalkyl, C3-5-cycloalkyl-Ci-3-alkyl, hyd roxy-C i -3-al ky I , Ci-3-alkoxy-Ci-3-alkyl, or C1-3- fluoroalkyl; or a pharmaceutically acceptable salt thereof.

2. A compound according to claim 1, wherein A represents pyridinyl, pyrimidinyl, pyrazinyl, or pyridazinyl, wherein A is independently unsubstituted, mono-, di- or tri-substituted, wherein the substituent(s), if any, is(are) as defined in claim 1; or a pharmaceutically acceptable salt thereof.

3. A compound according to claim 1 or 2, wherein said substituent of A / at least one of said substituents of A is 5- or 6-membered heteroaryl as defined in claim 1, wherein the substituent(s) of said 5- or 6-membered heteroaryl, if any, is(are) independently selected from Ci-4-al kyl as defined in claim 1; or a pharmaceutically acceptable salt thereof.

4. A compound according to claim 3, wherein said substituent of A / at least one of said substituents of A is• 5- or 6-membered heteroaryl containing from one to three ring heteroatom(s) independently selected from nitrogen, oxygen and sulfur; wherein said 5- or 6-membered heteroaryl is independently unsubstituted, mono- , di-, or tri-substituted, wherein the substituent(s), if any, is(are) independently selected from > Ci-4-alkyl which is■unsubstituted;■mono-substituted with❖ hydroxy; or❖ Ci-4-alkoxy;■di-substituted, wherein one substituent is hydroxy, and another substituent is trifluoromethyl; or two substituents are hydroxy; or■di- or tri-substituted, wherein two substituents are fluorine and, if present, one substituent is hydroxy; or a pharmaceutically acceptable salt thereof.

5. A compound according to claim 3, wherein said substituent of A / at least one of said substituents of A is 1,2,4- oxadiazol-5-yl or 1,2,4-oxadiazol-3-yl, wherein said oxadiazolyl groups are mono-substituted, wherein the substituent is independently selected from C -alkyl which is mono-substituted with hydroxy or C -alkoxy; or a pharmaceutically acceptable salt thereof.

6. A compound according to claim 3, wherein said substituent of A / at least one of said substituents of A is 1,2,4- oxadiazol-3-yl, which is mono-substituted, wherein the substituent is Ci-4-al kyl which is mono-substituted with hydroxy; or a pharmaceutically acceptable salt thereof.

7. A compound according to claim 1 or 2, wherein said substituent of A / at least one of said substituents of A is 5- or 6-membered heteroaryl as defined in claim 1, wherein the substituent(s) of said 5- or 6-membered heteroaryl, if any, is(are) independently selected from -L3-CY3as defined in claim 1; or a pharmaceutically acceptable salt thereof.

8. A compound according to claim 7, wherein said substituent of A / at least one of said substituents of A is> 1,2,4-oxadiazol-5-yl or 1,2,4-oxadiazol-3-yl, wherein said oxadiazolyl groups are mono-substituted, wherein the substituent is independently selected from • -L3-CY3, wherein■-L3- independently represents a bond, -CH2-, -CH2-CH2-, -C(CH3)2-, -CH(OH)-, or -0-CH2- , wherein when -L3- is -0-CH2-, said CY3is attached to the oxygen atom of said -0-CH2-; and■CY3independently represents piperidinyl, wherein said piperidinyl independently is unsubstituted, mono-, di-, or tri-substituted, wherein the substituents are selected from> halogen;> oxo;> hydroxy;> Ci-3-alkyl which is optionally mono-substituted with Ci.3-alkoxy;> Ci-3-alkoxy;> -(C=0)-Rco, wherein Rcorepresents o Ci-3-alkyl which is optionally mono-substituted with hydroxy or Ci.3-alkoxy; o Ci-3-fluoroalkyl; o Ci-3-alkoxy; o C3-6-cycloalkyl-(CH2)n-, wherein optionally one or two carbon ring atom(s) is / are replaced by oxygen ring atom(s); wherein n represents the integer 0, or 1; or o phenyl;> -S(=0)2-Rso, wherein Rsorepresents o Ci-3-alkyl which is optionally mono-substituted with hydroxy, Ci.3-alkoxy, or amino; and o C3-5-cycloalkyl, wherein optionally one carbon ring atom is replaced by one oxygen ring atom; or a pharmaceutically acceptable salt thereof.

9. A compound according to claim 1 or 2, wherein said substituent of A / at least one of said substituents of A independently is -CºC-RT1; or -CºC-C(OH)(RT2)(RT3); wherein said groups are as defined in claim 1; or a pharmaceutically acceptable salt thereof.

10. A compound according to claim 9, wherein said substituent of A / at least one of said substituents of A is• — CºC-RT1, wherein> RT1represents■Ci-4-alkyl, wherein said Ci-4-alkyl independently is mono-substituted with❖ hydroxy;❖ Ci_3-alkoxy;❖ -S(=0)2-Rsot, wherein RS0Trepresents Cu-alkyl, Ci-3-alkyl-amino, or C3-5- cycloalkyl;❖ -NRNT1RNT2wherein RNT1represents hydrogen and RNT2represents Ci-3-alkyl- carbonyl, C 1 -3- al koxy-C 1 -3-al ky l-car bony I , or C3-5-cycloalkyl-carbonyl;❖ C4-6-heterocyclyl containing one or two ring heteroatom(s) independently selected from nitrogen and oxygen; wherein said C4-6-heterocyclyl is mono-substituted with oxo; or di-substituted with oxo and Ci_3-al kyl; or❖ N-(Ci_3-alkyl-carbonyl)-piperidinyl-Ci_3-alkyl;■Ci-4-alkyl which is di-substituted, wherein one substituent is hydroxy, and a second substituent is trifluoromethyl;■C3-6-cycloalkyl which is mono-substituted with❖ hydroxy;❖ amino-sulfonyl which is optionally di-substituted with methyl;❖ phenyl which is mono-substituted with halogen;❖ pyridinyl;❖ pyrimidinyl which is mono-substituted with Ci_3-alkyl;❖ oxazolidinonyl;■C4-6-heterocyclyl containing one ring heteroatom independently selected from nitrogen and oxygen; wherein said C4-6-heterocyclyl is mono-, di-, or tri-substituted, wherein the substituent(s) is(are) independently selected from Ci-3-alkyl, hydroxy, oxo, Ci-3-alkyl- carbonyl, Ci-3-alkoxy-carbonyl, Ci-3-alkyl-sulfonyl, and Ci-3-alkyl-amino-sulfonyl;■indolyl;■3-hydroxy-1 -methyl-1, 3-dihydro-indol-2-on-3-yl; or• -CºC-C(OH)(RT2)(RT3), wherein RT2and RT3are as defined in claim 1 ; or a pharmaceutically acceptable salt thereof.

11. A compound according to any one of claims 1 to 10, which is also a compound of Formula (II)Formula (II); or a pharmaceutically acceptable salt thereof.

12. A compound according to claim 1 which is:(3-Fluoro-1-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;3-[Hydroxy-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methyl]-1-methyl-azetidine-3-carbonitrile;(R)-(1-Ethyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;(R)-(3-Methyl-1-propyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;(R)-(1-lsopropyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;(R)-(1-Cyclopropylmethyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;(R)-(1-Cyclobutyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;(R)-(1-lsobutyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;(R)-[1-(2-Fluoro-ethyl)-3-methyl-azetidin-3-yl]-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;(R)-[1-(2,2-Difluoro-ethyl)-3-methyl-azetidin-3-yl]-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;(R)-(1-tert-Butyl-3-methyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-methoxy-prop-1-ynyl)-pyridin-3-yl]-methanol3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-prop-1-yn-1-ol;4-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-methyl-but-3-yn-2-ol;(R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-yn-2-ol;(S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-yn-2-ol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclopentanol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclopropanol;3-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-azetidine-1- carboxylic acid tert-butyl ester;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclobutanol;4-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-yn-1-ol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(1-methyl-1 H-pyrazol-4-ylethynyl)-pyridin-3-yl]-methanol;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-phenyl-prop-2-yn-1-ol;4-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-phenyl-but-3-yn-2-ol;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-methyl-pent-1-yn-3-ol; 4-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-tetrahydro-pyran-4-ol; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(tetrahydro-pyran-4-yl)-prop-2-yn-1-ol;3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 -(1 ,3-dimethyl-1 H-pyrazol-4- yl)-prop-2-yn-1-ol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(tetrahydro-pyran-4-ylethynyl)-pyridin-3-yl]-methanol;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(2-methyl-thiazol-4-yl)-prop-2-yn-1-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(3-fluoro-phenyl)-but-3-yn-2- ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(4-methoxy-phenyl)-but-3- yn-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-phenyl)-but-3- yn-2-ol;4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-pyrazol-3-yl)- but-3-yn-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-thiazol-4-yl)-but-3- yn-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyridin-2-yl)-but-3-yn-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-pyrimidin-2-yl-but-3-yn-2-ol; 4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1 ,5-dimethyl-1 H-pyrazol-3- yl)-but-3-yn-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyrimidin-4-yl)- but-3-yn-2-ol;3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 -(1 ,5-dimethyl-1 H-pyrazol-3- yl)-prop-2-yn-1-ol;8-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-5,6,7J8-tetrahydro- quinolin-8-ol;7-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-6,7-dihydro-5H-[1]pyrindin-7-ol;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-pyridin-2-yl-pent-1-yn-3-ol;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(6-methoxy-pyridin-2-yl)- pent-1-yn-3-ol;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-azetidin- 1 -y l)-2-methy l-propan- 1 -one;(R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(1H-indol-2-ylethynyl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-methoxy-propyl)-pyridin-3-yl]-methanol;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-propan-1-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-methyl-butan-2-ol; (S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-butan-2-ol; (R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-butan-2-ol; 1-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-cyclopentanol; 1-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-cyclopropanol;3-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-3-hydroxy-azetidine- 1 -carboxylic acid tert-butyl ester;1-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-cyclobutanol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-butan-1-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[2-(1-methyl-1H-pyrazol-4-yl)-ethyl]-pyridin-3-yl}-methanol;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-phenyl-propan-1-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-phenyl-butan-2-ol; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-methyl-pentan-3-ol; 4-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-tetrahydro-pyran-4- ol;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(tetrahydro-pyran-4-yl)- propan-1 -ol;3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 -(1 ,3-dimethyl-1 H-pyrazol-4- yl)-propan-1-ol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[2-(tetrahydro-pyran-4-yl)-ethyl]-pyridin-3-yl}-methanol;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-(2-methyl-thiazol-4-yl)- propan-1 -ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(3-fluoro-phenyl)-butan-2-ol; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(4-methoxy-phenyl)-butan-2- ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-phenyl)-butan-2- ol;4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-pyrazol-3-yl)- butan-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-thiazol-4-yl)- butan-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyridin-2-yl)- butan-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-pyrimidin-2-yl-butan-2-ol; 4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1 ,5-dimethyl-1 H-pyrazol-3- yl)-butan-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyrimidin-4-yl)- butan-2-ol;3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 -(1 ,5-dimethyl-1 H-pyrazol-3- yl)-propan-1-ol;8-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-5,6,7,8-tetrahydro- quinolin-8-ol;7-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-6,7-dihydro-5H-[1]pyrindin-7-ol;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-pyridin-2-yl-pentan-3-ol;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(6-methoxy-pyridin-2-yl)- pentan-3-ol;(R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[2-(1H-indol-2-yl)-ethyl]-pyridin-3-yl}-(4-isopropyl-phenyl)-methanol; (R)-(4-Cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-{5-[3-(tetrahydro-pyran-4-yl)-[1 ,2,4]oxadiazol-5-yl]-pyridin-3-yl}- methanol;(R)-(4-Cyclopropyl-phenyl)-(1 ,3-dimethyl-azetidin-3-yl)-{5-[3-(2-methoxy-1 , 1 -dimethyl-ethyl)-[1 ,2,4]oxadiazol-5-yl]- pyridin-3-yl}-methanol;(R)-[5-(3-Cyclobutoxymethyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-(4-cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-propyl-phenyl)-{5-[3-(tetrahydro-pyran-4-yloxymethyl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-propyl-phenyl)-{5-[3-(tetrahydro-pyran-4-yl)-[1 ,2,4]oxadiazol-5-yl]-pyridin-3-yl}- methanol;(R)-[5-(3-Cyclobutoxymethyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-propyl-phenyl)- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-morpholin-4-ylmethyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[3-(2,6-dimethyl-morpholin-4-ylmethyl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-(4- isopropyl-phenyl)-methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(4-methyl-tetrahydro-pyran-4-yl)-[1 ,2,4]oxadiazol-5-yl]- pyridin-3-yl}-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[(1S,2S,4R)-3-(7-oxa-bicyclo[2.2.1]hept-2-yl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(tetrahydro-pyran-4-yloxymethyl)-[1 ,2,4]oxadiazol-5-yl]- pyridin-3-yl}-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-morpholin-4-yl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-methanol;(R)-(4-Cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-{5-[3-(4-methoxy-tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-5-yl]- pyridin-3-yl}-methanol;(R)-(4-Cyclopropyl-phenyl)-(1 ,3-dimethyl-azetidin-3-yl)-{5-[3-(3-hydroxymethyl-bicyclo[1.1.1]pent-1 -yl)- [1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[3-(3-hydroxymethyl-bicyclo[1.1.1]pent-1-yl)-[1,2,4]oxadiazol-5-yl]-pyridin-3-yl}-(4- isopropyl-phenyl)-methanol;2-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)-2- methyl-propan-1-ol;2-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)- propan-2-ol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(1 -methoxy-1 -methyl-ethyl)-[1 ,2,4]oxadiazol-5-yl]-pyridin-3- yl}-methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(1-methoxy-cyclobutyl)-[1 ,2,4]oxadiazol-5-yl]-pyridin-3-yl}- methanol;1-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)-2- methyl-propan-2-ol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methanesulfonylmethyl-[1 ,2,4]oxadiazol-3-yl)-pyridin-3-yl]- methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(2-methoxy-ethyl)-[1 ,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methoxymethyl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-furan-3-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- cyclohexanol;(R)-[5-(5-tert-Butoxymethyl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-4-ylmethyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol;4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- cyclohexanol;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-cyclohexanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1-methoxy-cyclobutyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(6-oxa-spiro[2.5]oct-1-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-3-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-(tetrahydro-furan-2-yl)methyl]-[1,2,4]oxadiazol-3-yl}- pyridin-3-yl)-methanol;(R)-2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- 1,1,1 -trifluoro-propan-2-ol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1 -methoxy-1 -methyl-ethyl)-[1 ,2,4]oxadiazol-3-yl]-pyridin-3- yl}-methanol;(R)-{5-[5-((R)-Cyclohexyl-hydroxy-methyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl- phenyl)-methanol;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- cyclopropanol;2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- cyclopentanol;3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- cyclobutanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[5-(4-fluoro-tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(4-isopropyl- phenyl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[5-((2R,4R,6S)-2,6-dimethyl-tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3- yl}-(4-isopropyl-phenyl)-methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-4-yloxymethyl)-[1 ,2,4]oxadiazol-3-yl]- pyridin-3-yl}-methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-methyl-1-(tetrahydro-pyran-4-yl)-ethyl]-[1 ,2,4]oxadiazol- 3-yl}-pyndin-3-yl)-methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[2-(tetrahydro-pyran-4-yl)-ethyl]-[1 ,2,4]oxadiazol-3-yl}- pyridin-3-yl)-methanol;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- cyclobutanol;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-2- methyl-propan-2-ol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(7-oxa-bicyclo[2.2.1]hept-2-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(4-methyl-tetrahydro-pyran-4-yloxymethyl)-[1 ,2,4]oxadiazol- 3-yl]-pyridin-3-yl}-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-oxetan-3-yl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-methanol; (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(2-methoxy-1 , 1 -dimethyl-ethyl)-[1 ,2,4]oxadiazol-3-yl]- pyridin-3-yl}-methanol;2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-2- methyl-propan-1-ol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(2-methoxy-2-methyl-propyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-cyclobutanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1-methoxymethyl-cyclopropylmethyl)-[1 ,2,4]oxadiazol-3-yl]- pyridin-3-yl}-methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(2-pyrazol-1-yl-ethyl)-[1 ,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;(R)-N-(2-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5- yl)ethyl)acetamide-2,2,2-d3;(R)-N-(1-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)-2- methylpropan-2-yl)acetamide-2,2,2-<¾;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1-yl]-2-hydroxy-ethanone;(R)-1-(4-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5- yl)piperidin-1-yl)ethan-1-one-2,2,2-d3;N-[2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- ethyl]-2-hydroxy-N-methyl-acetamide;(R)-N-(2-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)ethyl)- N-methylacetamide-d3;(1 ,3-Dimethyl-azetidin-3-yl)-(6-methoxy-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;(1 ,3-Dimethyl-azetidin-3-yl)-(6-phenoxy-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;(1 ,3-Dimethyl-azetidin-3-yl)-(6-ethoxy-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(5-methyl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;(1 ,3-Dimethyl-azetidin-3-yl)-(4-propyl-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;(1 ,3-Dimethyl-azetidin-3-yl)-(4-methoxy-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;(1 ,3-Dimethyl-azetidin-3-yl)-phenyl-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;(4-Cyclobutyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;(4-Cyclobutoxy-phenyl)-(1,3-dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;(1 ,3-Dimethyl-azetidin-3-yl)-(4-ethoxy-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;(4-tert-Butyl-phenyl)-(1 ,3-dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropoxy-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;(1 ,3-Dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methanol;(1 ,3-Dimethyl-azetidin-3-yl)-[4-(1-methyl-cyclopropyl)-phenyl]-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol; (4-Cyclopropoxy-phenyl)-(1,3-dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;(S)-[2-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-4-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (S)-[2-((3R,4S)-3,4-Difluoro-pyrrolidin-1-yl)-pyridin-4-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (S)-(1,3-Dimethyl-azetidin-3-yl)-(2-isobutoxy-pyridin-4-yl)-(4-isopropyl-phenyl)-methanol; 4-{4-[(S)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-2-yl}-2-methyl-butan-2-ol;(R)-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridazin-4-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;(S)-5-tert-Butyl-3-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-oxazolidin-2- one;(R)-1-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-3-ol;(S)-1-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-3-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((S)-3-hydroxymethyl-pyrrolidin-1-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;(S)-1-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-methyl-pyrrolidin-3-ol; 3-Cyclopropyl-1-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-3-ol; 2-((S)-1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-3-yl)-propan- 2-ol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-morpholin-4-yl-pyridin-3-yl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-5'-yl)-methanol; (R)-[5-(7-Aza-bicyclo[2.2.1]hept-7-yl)-pyridin-3-yl]-(1 ,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-((S)-2-methyl-pyrrolidin-1-yl)-pyridin-3-yl]-methanol;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-trifluoromethyl-pyrrolidin-3- ol;(R)-[5-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;5'-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-4-ol;5'-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-3-ol:(R)-{5-[(2-Benzyloxy-ethyl)-methyl-amino]-pyridin-3-yl}-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-[4-(1-methyl-cyclopropyl)-phenyl]-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;(R)-[5-((3R,4S)-3,4-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-(1 ,3-dimethyl-azetidin-3-yl)-[4-(1-trifluoromethyl-cyclopropyl)- phenylj-methanol;2-[(S)-1-(5-{(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)- pyrrolidin-3-yl]-propan-2-ol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methanol; (R)-(4-tert-Butyl-phenyl)-(1 ,3-dimethyl-azetidin-3-yl)-(3,4,5,6-tetrahydro-2H-[1 ,3']bipyridinyl-5'-yl)-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (R)-{5-[5-(1-Cyclopropanesulfonyl-piperidin-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(1,3-dimethyl-azetidin-3-yl)-(4- isopropyl-phenyl)-methanol;2-({5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-methyl-amino)-ethanol; (R)-1-((S)-1-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-3-yl)- ethanol;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-oxazolidin-2-one; 3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-5-phenyl-oxazolidin-2-one; 5-Benzyl-3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-oxazolidin-2-one;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-5-isopropyl-oxazolidin-2-one;6-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-oxa-6-aza-spiro[2.4]heptan- 5-one;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-oxa-3-aza-spiro[4.4]nonan-2-one;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-5-(tetrahydro-pyran-4-yl)- oxazolidin-2-one;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-5,5-dimethyl-oxazolidin-2-one;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-8,8-difluoro-1-oxa-3-aza- spiro[4.5]decan-2-one;9-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-7-oxa-9-aza- dispiro[3.1.4.1]undecan-8-one;2-Cyclopropyl-7-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-5-oxa-7-aza- spiro[3.4]octan-6-one;7-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2,2-dimethyl-5-oxa-7-aza- spiro[3.4]octan-6-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-phenyl-pyrrolidin-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-isopropyl-pyrrolidin-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-isopropyl-pyrrolidin-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4,4-dimethyl-pyrrolidin-2-one;5-(5-((R)-(1,3-Dimethyl-azetidin-3-yl)(hydroxy)(4-isopropyl-phenyl)methyl)pyridin-3-yl)hexahydro-4H-furo[2,3-c]pyrrol-4-one;2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-aza-spiro[4.4]nonan-3-one;6-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-6-aza-spiro[3.4]octan-5-one;2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-8-oxa-2-aza-spiro[4.5]decan-3-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(tetrahydro-pyran-4-yl)- pyrrolidin-2-one;2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-aza-spiro[4.5]decan-1-one; 2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-8-oxa-2-aza-spiro[4.5]decan- 1-one;(S)-1-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-isobutyl-pyrrolidin-2-one;4-Cyclopropyl-1-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-trifluoromethyl-pyrrolidin-2- one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(2-methoxy-ethyl)-pyrrolidin-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(2-methoxy-ethyl)-pyrrolidin-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-pyrrolidin-2-one;(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-((R)-3-isopropyl-pyrrolidin-1-yl)-pyridin-3-yl]-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((2R,6S)-2,6-dimethyl-morpholin-4-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(6-oxa-3-aza-bicyclo[3.1.1]hept-3-yl)-pyridin-3-yl]-methanol;(R)-[5-((3R,4S)-3,4-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;(R)-[5-((3S,4S)-3,4-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((2S,6S)-2,6-dimethyl-morpholin-4-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((2R,6R)-2,6-dimethyl-morpholin-4-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyrrolidin-1-yl]-pyridin-3-yl}- methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(4-methyl-thiazol-2-yl)-pyrrolidin-1-yl]-pyridin-3-yl}- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-phenyl-pyrrolidin-1-yl)-pyridin-3-yl]-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(3,3-dimethyl-pyrrolidin-1-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[(1S,4S)-5-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-pyridin-3-yl]- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(2,2,6,6-tetrafluoro-morpholin-4-yl)-pyridin-3-yl]-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-((R)-2-methoxymethyl-morpholin-4-yl)-pyridin-3-yl]-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-((S)-2-methoxymethyl-morpholin-4-yl)-pyridin-3-yl]-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-trifluoromethyl-pyrrolidin-1-yl)-pyridin-3-yl]-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[(1R,4R)-5-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-pyridin-3-yl]- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[(1S,5R)-5-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-pyridin-3-yl]- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-[(1S,4S)-5-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-pyridin-3-yl]-[4-(1-trifluoromethyl- cyclopropyl)-phenyl]-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-[5-(6-oxa-3-aza-bicyclo[3.1.1]hept-3-yl)-pyridin-3-yl]-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-[(1S,4S)-5-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-pyridin-3-yl]- methanol;(R)-(5-Benzyloxy-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(2-pyridin-2-yl-ethoxy)-pyridin-3-yl]-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(2-methoxy-ethoxy)-pyridin-3-yl]-methanol;(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(oxetan-3-ylmethoxy)-pyridin-3-yl]-methanol;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-propan-1-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(5-isopropoxy-pyridin-3-yl)-(4-isopropyl-phenyl)-methanol; (R)-(5-Cyclohexyloxy-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-2-methyl-propan-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-methoxy-cyclopentyloxy)-pyridin-3-yl]-methanol; (R)-[5-(3-Cyclopropyl-[1,2,4]oxadiazol-5-ylmethoxy)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[2-(3,5-dimethyl-[1,2,4]triazol-1-yl)-ethoxy]-pyridin-3-yl}-(4-isopropyl-phenyl)- methanol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-2-methyl-butan-2-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-methoxy-pyridin-3-yl)-methanol; (R)-[5-(2-Benzyloxy-ethoxy)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(tetrahydro-pyran-4-yloxy)-pyridin-3-yl]-methanol;2-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-ethanol; 4-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-cyclohexanol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-1-methyl-cyclohexanol; (1,3-Dimethyl-azetidin-3-yl)-(2-phenoxy-pyrimidin-5-yl)-(4-trifluoromethoxy-phenyl)-methanol; (6-Benzyloxy-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(5-pyrazol-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(6-fluoro-5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethoxy-phenyl)-methanol;5-[(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-3-pyrrolidin-1-yl-pyridine-2-carbonitrile; (1,3-Dimethyl-azetidin-3-yl)-[6-(tetrahydro-pyran-4-yloxy)-pyridin-3-yl]-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-[6-(oxetan-3-ylmethoxy)-pyridin-3-yl]-(4-trifluoromethoxy-phenyl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(4-methyl-thiazol-2-yl)-pyridin-3-yl]-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methyl-thiazol-2-yl)-pyridin-3-yl]-methanol; (1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(2-methoxy-pyrimidin-5-yl)-methanol;(S)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(2-pyrrolidin-1-yl-pyridin-4-yl)-methanol; (1,3-Dimethyl-azetidin-3-yl)-[2-((R)-2-hydroxymethyl-pyrrolidin-1-yl)-pyridin-4-yl]-(4-isopropyl-phenyl)-methanol;(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4'-yl)-methanol;(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(2-morpholin-4-yl-pyridin-4-yl)-methanol; (S)-(1,3-Dimethyl-azetidin-3-yl)-(2-ethyl-pyridin-4-yl)-(4-isopropyl-phenyl)-methanol;(S)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[2-(tetrahydro-pyran-4-ylmethoxy)-pyridin-4-yl]-methanol;(S)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[2-(2-methoxy-ethoxy)-pyridin-4-yl]-methanol;(S)-(2-Cyclopentyl-pyridin-4-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-(4-trifluoromethyl-phenyl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((R)-3-hydroxymethyl-3-methyl-pyrrolidin-1-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-[5-((S)-3-fluoro-pyrrolidin-1-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[4-(tetrahydro-pyran-4-yl)-[1,2,3]triazol-1-yl]-pyridin-3-yl}- methanol;(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-methyl-pyridin-3-yl)-methanol;(1,3-Dimethyl-azetidin-3-yl)-(5-isopropenyl-pyridin-3-yl)-(4-isopropyl-phenyl)-methanol;(5-Cyclopropyl-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;(5-Cyclopent-1-enyl-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;3-{5-[(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-cyclopent-2-enol;(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-isopropyl-pyridin-3-yl)-methanol;(5-Cyclopentyl-pyridin-3-yl)-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;3-{5-[(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-cyclopentanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-pyridin-3-yl-methanol;3-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-cyclopent-2-enone;3-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-methyl-cyclopent-2-enol;(3S)-3-(5-((R)-(1, 3-dimethyl azetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1-methylcyclopentan-1-ol;(3R)-3-(5-((R)-(1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1-methylcyclopentan-1-ol;3-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-ethyl-cyclopentanol;3-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-isopropyl-cyclopentanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(4-methyl-oxazol-2-yl)-pyridin-3-yl]-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(5-ethyl-pyridin-3-yl)-(4-isopropyl-phenyl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-methyl-pyridin-3-yl)-methanol;(R)-[5-(4,5-Dihydro-furan-3-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(tetrahydro-furan-3-yl)-pyridin-3-yl]-methanol;3-{5-[(R)-(1J3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-en-1-ol;N-Cyclopentyl-5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-nicotinamide;{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidin-1-yl-methanone;5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-N-(tetrahydro-pyran-4-yl)-nicotinamide;(1 ,3-Dimethyl-azetidin-3-yl)-[4-(3-methoxy-propyl)-phenyl]-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;(R)-(4-Cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(5-pyrrolidin-1-yl-pyridin-3-yl)-p-tolyl-methanol;5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'- carboxylic acid tert-butyl ester;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(tetrahydro-pyran-4-yl)-pyridin-3-yl]-methanol;(R)-(1l3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(3'l4'l5'l6'-tetrahydro-2'H-[2l1';4'l3"]terpyridin-5"-yl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(1'-phenyl-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-5-yl)- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[1'-(toluene-4-sulfonyl)-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-5-yl]-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(tetrahydro-furan-2-yl)-pyridin-3-yl]-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methyl-tetrahydro-furan-2-yl)-pyridin-3-yl]-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(5,5-dimethyl-tetrahydro-furan-2-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2,2-difluoro-propan-1-ol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methyl-oxazol-2-yl)-pyridin-3-yl]-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-4-yl)-oxazol-2-yl]-pyridin-3-yl}-methanol; (R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(4-fluoro-phenoxymethyl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol; Isopropyl-carbamic acid 5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylmethyl ester;(R)-[5-(2-Benzyloxy-ethyl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-methyl-cyclohexanol; 2-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-cyclopropyl)-propan-2-ol;(S)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{2-[5-(tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-4-yl}- methanol;(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(2-pyrrolidin-1-yl-pyrimidin-5-yl)-methanol;(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(6-pyrrolidin-1-yl-pyrazin-2-yl)-methanol;(R)-N-(1-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5- yl)cyclopropyl)acetamide-2,2,2-d3;(R)-N-(1-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5- yl)cyclopropyl)-N-methylacetamide-d3;(R)-N-((3-(5-((1, 3-dimethyl azetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1, 2, 4-oxadiazol-5-yl)methyl)- N-methylacetamide-d3;N-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-2-hydroxy-acetamide;(R)-N-((3-(5-((1, 3-dimethyl azetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1, 2, 4-oxadiazol-5- yl)methyl)acetamide-2,2,2-d3;1-(3-{5-[(R)-Hydroxy-(1-isopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-2-methyl-propan-2-ol;1-(3-{5-[(R)-(1-Ethyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-2- methyl-propan-2-ol;2-(3-{5-[(R)-Hydroxy-(1-isopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-propan-2-ol;2-(3-{5-[(R)-(1-Ethyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)- piperidine-1 -carboxylic acid benzyl ester;1-[4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)- piperidin-1 -yl]-ethanone;(R)-1-(3-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5- yl)azetidin-1-yl)ethan-1-one-2,2,2-d3;(R)-1-(3-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)-3- methylazetidin-1-yl)ethan-1-one-2,2,2-d3;(R)-1-(3-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-isopropylphenyl)methyl)pyridin-3-yl)-1,2,4-oxadiazol-5-yl)-3- fluoroazetidin-1 -yl)ethan-1 -one-2,2,2-d3;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1 -methyl-1 -morpholin-4-yl-ethyl)-[1, 2, 4]oxadiazol-3-yl]- pyridin-3-yl}-methanol;4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- methyl-piperidin-2-one;1-[(S)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-pyrrolidin-1-yl]-ethanone;1-[(R)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-pyrrolidin-1-yl]-ethanone;N-[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- methyl-ethyl]-acetamide;1-Benzyl-3-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-pyrrolidin-2-one;3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1,3- dimethyl-pyrrolidin-2-one;4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- isobutyl-pyrrolidin-2-one;4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- furan-2-ylmethyl-pyrrolidin-2-one;4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- phenyl-pyrrolidin-2-one;1-Benzyl-4-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-pyrrolidin-2-one;5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- phenyl-pyrrolidin-2-one;4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- pyrrolidin-2-one;(S)-5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- pyrrolidin-2-one;(R)-5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- pyrrolidin-2-one;(S)-6-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-2-one;4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-2-one;(S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- azetidin-2-one;(S)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- azetidin-2-one;(S)-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1,4- dimethyl-pyrrolidin-2-one;(R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- 1 ,4-dimethyl-pyrrolidin-2-one;(R) or (S)-4-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol- 5-yl)-1,4-dimethyl-pyrrolidin-2-one;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-piperidin-4-yl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-methanol; (R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(4-methyl-piperidin-4-yl)-[1 ,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[5-(4-fluoro-piperidin-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(4-isopropyl-phenyl)- methanol;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-butan-1 -one;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-2,2-dimethyl-propan-1 -one;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1-yl]-2-methoxy-ethanone;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1-yl]-3-methoxy-propan-1-one;Cyclopropyl-[4-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone;Cyclopentyl-[4-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone;[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-5-yl)- piperidin-1-yl]-(tetrahydro-pyran-4-yl)-methanone;[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-5-yl)- piperidin-1-yl]-phenyl-methanone;4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidine-1 -carboxylic acid methyl ester;4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidine-1 -carboxylic acid ethyl ester;4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidine-1 -carboxylic acid 2-methoxy-ethyl ester;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1-methanesulfonyl-piperidin-4-yl)-[1,2,4]oxadiazol-3-yl]- pyridin-3-yl}-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-(propane-2-sulfonyl)-piperidin-4-yl]-[1,2,4]oxadiazol-3-yl}- pyridin-3-yl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-(propane-1-sulfonyl)-piperidin-4-yl]-[1,2,4]oxadiazol-3-yl}- pyridin-3-yl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-(2-methoxy-ethanesulfonyl)-piperidin-4-yl]-[1,2,4]oxadiazol-3-yl}-pyridin-3-yl)-methanol;2-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidine-1 -sulfonyl]-ethanol;(R)-{5-[5-(1-Cyclopentanesulfonyl-piperidin-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(1,3-dimethyl-azetidin-3-yl)-(4- isopropyl-phenyl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{5-[1-(tetrahydro-pyran-4-sulfonyl)-piperidin-4-yl]-[1,2,4]oxadiazol-3-yl}-pyridin-3-yl)-methanol;4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidine-1 -sulfonic acid methylamide;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(1-methylamino-cyclopropyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-methanol;[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-5-yl)- cyclopropyl]-methyl-carbamic acid ethyl ester;N-[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- cyclopropyl]-N-methyl-methanesulfonamide;(R)-(1,3-Dimethyl-azetidin-3-yl)-[6-(2,2-dimethyl-cyclopentyloxy)-pyridazin-4-yl]-(4-isopropyl-phenyl)-methanol;(R)-[6-(3,3-Difluoro-cyclopentyloxy)-pyridazin-4-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol;2-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yloxy}-phenyl)-ethanol;2-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yloxy}-phenyl)-ethanol;(R)-[6-(Chroman-6-yloxy)-pyridazin-4-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; 6-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yloxy}-3H-benzooxazol-2-one; 1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(6-methyl-pyrimidin-4-yl)- pent-1-yn-3-ol;(S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyrimidin-4- yl)-but-3-yn-2-ol;(R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyrimidin-4- yl)-but-3-yn-2-ol;(S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1,5-dimethyl-1H- pyrazol-3-yl)-but-3-yn-2-ol;(R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1,5-dimethyl-1H- pyrazol-3-yl)-but-3-yn-2-ol;(R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1,5-dimethyl-1H- pyrazol-3-yl)-but-3-yn-2-ol;(S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1 ,5-dimethyl-1 H- pyrazol-3-yl)-but-3-yn-2-ol;(R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[1-(4-fluoro-phenyl)-cyclopropylethynyl]-pyridin-3-yl}-(4-isopropyl-phenyl)-methanol;(S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-pyrazol-3- yl)-but-3-yn-2-ol;(R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-pyrazol-3- yl)-but-3-yn-2-ol;(R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-pyrazol-3- yl)-but-3-yn-2-ol;(S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-pyrazol-3- yl)-but-3-yn-2-ol;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-pyrrolidine-1 -carboxylic acid tert-butyl ester;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-piperidine-1-carboxylic acid tert-butyl ester;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-3-(6-methyl-pyrimidin-4-yl)- pentan-3-ol;2-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-benzoic acid methyl ester;(R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[2-(2-hydroxymethyl-phenyl)-ethyl]-pyridin-3-yl}-(4-isopropyl-phenyl)-methanol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyrimidin-4-yl)- butan-2-ol;3-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-3-hydroxy- pyrrolidine-1 -carboxylic acid tert-butyl ester;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[2-(1H-pyrrolo[2,3-b]pyridin-2-yl)-ethyl]-pyridin-3-yl}-methanol;4-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-piperidine-1- carboxylic acid tert-butyl ester;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-pyridin-2-yl-butan-2-ol; 1-Cyclopropyl-3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-pyridin-2-yl- propan-1 -ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(5-methyl-pyridin-3-yl)- butan-2-ol;8-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-ethyl)-5,6,7,8-tetrahydro- quinolin-8-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-2-(6-methoxy-pyridin-2-yl)- butan-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-2-(6-methyl-pyridin-2-yl)- butan-2-ol;(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(6-pyrrolidin-1-yl-pyridin-2-yl)-methanol;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- fluoro-piperidin-1-yl]-ethanone;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- methyl-piperidin-1-yl]-ethanone;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxy}-cyclohexanone; 4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-cyclohexanol; (R)-(5-Cyclopentyloxymethyl-pyridin-3-yl)-(1 ,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methanol; 1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylmethoxy}-piperidin-1-yl)- ethanone;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[6-(tetrahydro-pyran-4-yl)-pyridazin-4-yl]-methanol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-2-phenyl-butan-2-ol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{6-[(S)-(tetrahydro-furan-3-yl)oxy]-pyridazin-4-yl}-methanol;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{6-[(R)-(tetrahydro-furan-3-yl)oxy]-pyridazin-4-yl}-methanol;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4-methyl-pyrrolidin-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-3-isopropyl-pyrrolidin-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-3,3-dimethyl-pyrrolidin-2- one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4,4-dimethyl-pyrrolidin-2- one;5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-5-aza-spiro[2.4]heptan-6- one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4-trifluoromethyl-pyrrolidin-2-one;4-Cyclopropyl-1-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-pyrrolidin-2- one;2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-8-oxa-2-aza- spiro[4.5]decan-3-one;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-1-oxa-3-aza- spiro[4.5]decan-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4-pyridin-2-yl-pyrrolidin-2- one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-3-(2-methoxy-ethyl)- pyrrolidin-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4-phenyl-pyrrolidin-2-one;2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-2,3-dihydro-isoindol-1-one; 2-(3-{5-[(S)-(3-Fluoro-1-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;2-(3-{5-[(S)-(1-Cyclopropyl-3-fluoro-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol;1-[4-(3-{5-[(S)-(3-Fluoro-1-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-piperidin-1 -yl]-ethanone;1-[4-(3-{5-[(S)-(1-Cyclopropyl-3-fluoro-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone;2-(3-{5-[(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol- 5-yl)-propan-2-ol;1-[4-(3-{5-[(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1.2.4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone;(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(tetrahydro-pyran-4-yl)-[1 ,2,4]oxadiazol-3-yl]- pyridin-3-yl}-methanol; trans-4-(3-{5-[(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1.2.4]oxadi azol-5-y l)-cyclohexanol ;(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-oxetan-3-yl-[1 ,2,4]oxadiazol-3-yl)-pyridin-3-yl]- methanol;1-[(R)-3-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-5- ylmethyl)-pyrrolidin-1-yl]-ethanone;1-[3-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone;1-[3-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-3- hydroxy-piperidin-1-yl]-ethanone;1-[3-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-3- methyl-piperidin-1-yl]-ethanone;1-[3-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-5- ylmethyl)-piperidin-1-yl]-ethanone;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-4-hydroxy-piperidin-1-yl]-ethanone;N-[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-cyclopropyl]-acetamide;Tetrahydro-pyran-4-carboxylic acid [1-(3-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]- pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-cyclopropyl]-amide;N-[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-cyclopropyl]-2-methoxy-acetamide;N-[1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-cyclopropyl]-N-methyl-acetamide;N-[2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1 , 1 -dimethyl-ethyl]-propionamide;N-[2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1 , 1 -dimethyl-ethyl]-2-methoxy-acetamide;Tetrahydro-pyran-4-carboxylic acid [2-(3-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]- pyridin-3-yl}-[1 ,2,4]oxadiazol-5-yl)-1 , 1-dimethyl-ethyl]-amide;N-[2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1 , 1 -dimethyl-ethyl]-isobutyramide;Cyclopropanecarboxylic acid [2-(3-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3- yl}-[1,2,4]oxadiazol-5-yl)-1,1-dimethyl-ethyl]-amide;1-[cis-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-2-methyl-piperidin-1-yl]-ethanone;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- hydroxy-piperidin-1-yl]-2-methyl-propan-1-one;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- hydroxy-piperidin-1 -yl]-propan-1 -one;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- methoxy-piperidin-1-yl]-ethanone;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1-yl]-3,3,3-trifluoro-propan-1-one;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1-yl]-2-oxetan-3-yl-ethanone;1-[4-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- ethyl-piperidin-1 -yl]-ethanone;[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-5-yl)- piperidin-1-yl]-oxetan-3-yl-methanone;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- isopropyl-piperidin-1-yl]-2-methoxy-ethanone;1-[cis-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-3-methyl-piperidin-1-yl]-ethanone;5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- methyl-piperidin-2-one;5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-5- methyl-piperidin-2-one;5-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-2-one;4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- methyl-pyrrolidin-2-one;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-3,3-dimethyl-pyrrolidine-2,5-dione;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-imidazolidine-2,4-dione;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-pyrrolidin-2-one;3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-imidazolidine-2,4-dione;3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-1-methyl-imidazolidine-2,4-dione;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-3-methyl-imidazolidine-2,4-dione;3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-oxazolidin-2-one;1-Cyclopropyl-3-(3-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-ylmethyl)-imidazolidin-2-one;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-pyrrolidine-2,5-dione;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-3-methyl-imidazolidin-2-one;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-imidazolidin-2-one;2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propane-1 ,2-diol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-pyridin-3-yl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-methanol;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-piperidin-1-yl]-ethanone;(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- acetonitrile;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-4- hydroxy-piperidin-1-yl]-ethanone;3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propionitrile;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-3- methoxy-piperidin-1-yl]-ethanone;1-[(R)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-piperidin-1 -yl]-ethanone;4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- tetrahydro-pyran-4-ol;(R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[5-(3-hydroxymethyl-bicyclo[1.1.1]pent-1-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(4- isopropyl-phenyl)-methanol;4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- methyl-piperidine-2, 6-dione;2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-2,2- difluoro-ethanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(3-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(5-isopropyl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[5-(6-methyl-pyrimidin-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}- methanol;(R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- methyl-pyrrolidin-2-one;(S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- methyl-pyrrolidin-2-one;(S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- ethyl-pyrrolidin-2-one;(R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- ethyl-pyrrolidin-2-one;(R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- ethyl-pyrrolidin-2-one;(S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- ethyl-pyrrolidin-2-one;(S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- isopropyl-pyrrolidin-2-one;(R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- isopropyl-pyrrolidin-2-one;(R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- isopropyl-pyrrolidin-2-one;(S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-1- isopropyl-pyrrolidin-2-one;1-[(S)-3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- ylmethyl)-pyrrolidin-1-yl]-ethanone;(S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-2-one;(R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-2-one;(R)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-2-one;(S)-4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-2-one;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(5-methyl-[1,2,4]oxadiazol-3-yl)-pyridin-3-yl]-methanol;(R)-{5-[5-(1,1-Difluoro-ethyl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)- methanol;4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)- tetrahydro-pyran-4-ol;(R)-[5-(3-tert-Butoxymethyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-(1,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)- methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-[5-(3-hydroxymethyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-yl]-(4-isopropyl-phenyl)-methanol;1-[4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)- piperazin-1 -yl]-ethanone;1-[3-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3- ylmethyl)-azetidin-1-yl]-ethanone;4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3- ylmethyl)-tetrahydro-pyran-4-ol;[4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-3-yl)- piperidin-1-yl]-[1,4]dioxan-2-yl-methanone;1-[4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)- piperidin-1-yl]-2-methoxy-ethanone;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[3-(1-methanesulfonyl-piperidin-4-yl)-[1 ,2,4]oxadiazol-5-yl]- pyridin-3-yl}-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-{3-[1-(2-methoxy-ethanesulfonyl)-piperidin-4-yl]-[1.2.4]oxadiazol-5-yl}-pyridin-3-yl)-methanol;1-[4-(5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-3-yl)- piperidin-1-yl]-2-hydroxy-ethanone;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-(5-[1,2,4]oxadiazol-3-yl-pyridin-3-yl)-methanol;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone;2-(3-{5-[(R)-(4-Bromo-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan- 2-ol;2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-naphthalen-2-yl-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2- ol;2-[3-(5-{(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-[1.2.4]oxadiazol-5-yl]-propan-2-ol;2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-phenyl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-propan-2-ol;2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropoxy-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1 ,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-propan-2-ol;(R)-2-(3-(5-((1,3-dimethylazetidin-3-yl)(hydroxy)(4-(pentafluoro- 6-sulfaneyl)phenyl) methyl)pyridin-3-yl)-1,2,4- oxadiazol-5-yl)propan-2-ol;2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-(3-fluoro-4-isopropyl-phenyl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-propan-2-ol;2-(3-{5-[(R)-(4-tert-Butyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;2-(3-{5-[(R)-Benzo[b]thiophen-5-yl-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-pentafluoroethyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-propan-2-ol;2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-methyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-propan-2-ol;2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-3-methyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2-ol;2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-propan-2-ol;1-[4-(3-{5-[(R)-(4-Bromo-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone;2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-[4-(1-fluoro-1-methyl-ethyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1.2.4]oxadiazol-5-yl]-propan-2-ol;2-(3-{5-[(R)-[4-(1,1-Difluoro-ethyl)-phenyl]-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-propan-2-ol;2-(3-{5-[(R)-(4-Bicyclo[1.1.1]pent-1-yl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1.2.4]oxadiazol-5-yl)-propan-2-ol;(R)-(1,3-Dimethyl-azetidin-3-yl)-{5-[5-(tetrahydro-pyran-4-yl)-[1,2,4]oxadiazol-3-yl]-pyridin-3-yl}-[4-(2,2,2-trifluoro- ethyl)-phenyl]-methanol;2-[3-(5-{(R)-(1 ,3-Dimethyl-azetidin-3-yl)-[4-(1 , 1 -dimethyl-propyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1.2.4]oxadiazol-5-yl]-propan-2-ol;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-(3-fluoro-4-isopropyl-phenyl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone;1-{4-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-[1.2.4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropoxy-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone;2-(3-{5-[(R)-(3-Chloro-4-isopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-propan-2-ol;2-(3-{5-[(R)-(4-Cyclobutyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;1-[4-(3-{5-[(R)-(4-Cyclobutyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone;1-[4-(3-{5-[(R)-(3,5-Difluoro-4-isopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1.2.4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone;2-(3-{5-[(R)-(3,5-Difluoro-4-isopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1.2.4]oxadiazol-5-yl)-propan-2-ol;1-[4-(3-{5-[(R)-(4-Cyclobutoxy-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone;2-[3-(5-{(1,3-Dimethyl-azetidin-3-yl)-[4-(1-ethyl-propyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]- propan-2-ol;1-{4-[3-(5-{(1,3-Dimethyl-azetidin-3-yl)-[4-(1-ethyl-propyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]- piperidin-1 -yl}-ethanone;2-[3-(5-{(1,3-Dimethyl-azetidin-3-yl)-[4-(2,2-dimethyl-propyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5- yl]-propan-2-ol;1-{4-[3-(5-{(1,3-Dimethyl-azetidin-3-yl)-[4-(2,2-dimethyl-propyl)-phenyl]-hydroxy-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone;1-{4-[3-(5-{(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-methyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-[1.2.4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone;2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-propyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan- 2-ol;2-(3-{5-[(R)-(4-Cyclopropyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2- ol;2-(3-{5-[(R)-(4-Butyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-propan-2- ol;2-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethyl-phenyl)-methyl]-pyridin-3-yl}-[1 ,2,4]oxadiazol-5-yl)- propan-2-ol;2-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(2,2,2-trifluoro-ethyl)-phenyl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-propan-2-ol;2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isobutyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;2-(3-{5-[(R)-(4-Cyclobutoxy-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;2-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropenyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- propan-2-ol;1-{4-[3-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(2,2,2-trifluoro-ethyl)-phenyl]-methyl}-pyridin-3-yl)-[1.2.4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-propyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)- piperidin-1 -yl]-ethanone;1-[4-(3-{5-[(R)-Hydroxy-(1-isopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone;1-[4-(3-{5-[(R)-[1-(2,2-Difluoro-ethyl)-3-methyl-azetidin-3-yl]-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1.2.4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone;1-[4-(3-{5-[(R)-Hydroxy-[1-(2-hydroxy-ethyl)-3-methyl-azetidin-3-yl]-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone;1-[4-(3-{5-[(R)-(1-Cyclopropylmethyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1.2.4]oxadiazol-5-yl)-piperidin-1-yl]-ethanone;1-{4-[3-(5-{(R)-Hydroxy-(4-isopropyl-phenyl)-[1-(2-methoxy-ethyl)-3-methyl-azetidin-3-yl]-methyl}-pyridin-3-yl)-[1.2.4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone;1-{4-[3-(5-{(R)-Hydroxy-(4-isopropyl-phenyl)-[3-methyl-1-(3,3,3-trifluoro-propyl)-azetidin-3-yl]-methyl}-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-ethanone;1-[4-(3-{5-[(R)-Hydroxy-(4-isopropyl-phenyl)-(3-methyl-1-propyl-azetidin-3-yl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-piperidin-1 -yl]-ethanone;1-[4-(3-{5-[(R)-(1-Ethyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-[1,2,4]oxadiazol-5- yl)-piperidin-1 -yl]-ethanone;1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-piperidin-1-yl)- ethanone;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1,1-trifluoro-2-methyl-but-3- yn-2-ol;Cyclopropanecarboxylic acid (3-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}- 1 , 1 -dimethyl-prop-2-ynyl)-amide;N-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 -dimethyl-prop-2-ynyl)- isobutyramide;N-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 -dimethyl-prop-2-ynyl)-2-methoxy-acetamide;3-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 -dimethyl-prop-2-ynyl)- oxazolidin-2-one;1 -(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 -dimethyl-prop-2-ynyl)- pyrrolidin-2-one;1 -(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 -dimethyl-prop-2-ynyl)-3- methyl-imidazolidin-2-one;1 -(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 -dimethyl-prop-2-ynyl)- imidazolidin-2-one;3-(1-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclopropyl)- oxazolidin-2-one;1-((R)-2-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-2-methyl- pyrrolidin-1-yl)-ethanone;1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-4-hydroxy-piperidin-1-yl)-ethanone;1-[4-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-hydroxy-1-methyl- prop-2-ynyl)-piperidin-1-yl]-ethanone;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-hydroxy-prop-2-ynyl)- piperidin-1 -yl]-ethanone;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-prop-2-ynyl)-piperidin-1- yl]-ethanone;1-[4-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1-hydroxy-prop-2-ynyl)-4-methyl-piperidin-1-yl]-ethanone;1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-4-methyl-piperidin-1- yl)-ethanone;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(1-methanesulfonyl-piperidin-4-ylethynyl)-pyridin-3-yl]- methanol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-4-methyl-piperidine-1- sulfonic acid methylamide;(R)-(1 ,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(3-methanesulfonyl-3-methyl-but-1-ynyl)-pyridin-3-yl]- methanol;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclopropanesulfonic acid dimethylamide;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-cyclopropanesulfonic acid amide;(R)-[5-(3-Cyclopropanesulfonyl-3-methyl-but-1-ynyl)-pyridin-3-yl]-(1 ,3-dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)- methanol;(R)-3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-1- methyl-pyrrolidin-2-one;(S)-3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-1- methyl-pyrrolidin-2-one;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3,4-dihydro-2H- pyrano[3,2-b] pyridin-4-ol;3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-ylethynyl}-3-hydroxy-1-methyl- 1,3-dihydro-indol-2-one;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1H-indazol-3-yl)-but-3-yn-2- ol;4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-indazol-3-yl)- but-3-yn-2-ol;2-(1-Cyclopropyl-1H-pyrazol-3-yl)-4-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3- yl}-but-3-yn-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-pyrimidin-4-yl)- but-3-yn-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(5-methyl-pyrazin-2-yl)-but-3-yn-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-thiazol-5-yl)-but-3- yn-2-ol;2-(6-Cyclopropyl-pyrimidin-4-yl)-4-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3- yl}-but-3-yn-2-ol;(R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyrimidin-4- yl)-but-3-yn-2-ol;(S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyrimidin-4- yl)-but-3-yn-2-ol;N-(3-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 -dimethyl-prop-2-ynyl)- acetamide;(S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyrimidin-4- yl)-but-3-yn-2-ol;(R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-pyrimidin-4- yl)-but-3-yn-2-ol;(R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-pyrimidin-4- yl)-but-3-yn-2-ol;(S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-pynmidin-4- yl)-but-3-yn-2-ol;(S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-pynmidin-4- yl)-but-3-yn-2-ol;(R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-pyrimidin-4- yl)-but-3-yn-2-ol;(S)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2,6-dimethyl-pyrimidin- 4-yl)-but-3-yn-2-ol;(R)-4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2,6-dimethyl-pyrimidin-4-yl)-but-3-yn-2-ol;(R)-(S)-2-(2,6-Dimethoxy-pyrimidin-4-yl)-4-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]- pyridi n-3-y l}-but-3-yn-2-ol ;(S)-2-(2,6-Dimethoxy-pyrimidin-4-yl)-4-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]- pyridin-3-yl}-but-3-yn-2-ol;(R)-2-(2,6-Dimethoxy-pyrimidin-4-yl)-4-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]- pyridi n-3-y l}-but-3-yn-2-ol ;(S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-6-methyl- pyrimidin-4-yl)-but-3-yn-2-ol;(R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methoxy-6-methyl- pyrimidin-4-yl)-but-3-yn-2-ol;(R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-2-methyl- pyrimidin-4-yl)-but-3-yn-2-ol;(S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-2-methyl- pyrimidin-4-yl)-but-3-yn-2-ol;(S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-2-methyl- pyrimidin-4-yl)-but-3-yn-2-ol;(R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methoxy-2-methyl- pyrimidin-4-yl)-but-3-yn-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-trifluoromethyl-pyrimidin-4-yl)-but-3-yn-2-ol;2-(6-Difluoromethyl-pyrimidin-4-yl)-4-{5-[(R)-(1 ,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-but-3-yn-2-ol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-[5-(1-pyridin-2-yl-cyclopropylethynyl)-pyridin-3-yl]-methanol;(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-isopropyl-phenyl)-{5-[1-(6-methyl-pyrimidin-4-yl)-cyclopropylethynyl]-pyridin-3-yl}- methanol;1-[4-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-piperidin-1-yl]- ethanone;4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1 , 1 , 1 -trifluoro-2-methyl-butan-2-ol;3-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1 -dimethyl-propyl)- oxazolidin-2-one;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1 -dimethyl-propyl)- pyrrolidin-2-one;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1-dimethyl-propyl)-3- methyl-imidazolidin-2-one;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-1,1 -dimethyl-propyl)- imidazolidin-2-one;1-[(S)-2-(2-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-ethyl)-2-methyl- pyrrolidin-1-yl]-ethanone;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1H-indazol-3-yl)-butan-2-ol;2-(1-Cyclopropyl-1H-pyrazol-3-yl)-4-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3- yl}-butan-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-pyrimidin-4-yl)- butan-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(5-methyl-pyrazin-2-yl)- butan-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-methyl-thiazol-5-yl)- butan-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(3-methyl-isoxazol-5-yl)-but-3-yn-2-ol;4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-imidazol-2-yl)- but-3-yn-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(5-methyl-thiophen-2-yl)-but-3-yn-2-ol;4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(1-methyl-1 H-pyrrol-2-yl)- but-3-yn-2-ol;(R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-trifluoromethyl- pyrimidin-4-yl)-but-3-yn-2-ol;(S)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-trifluoromethyl- pyrimidin-4-yl)-but-3-yn-2-ol;(S)-(R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-trifluoromethyl- pyrimidin-4-yl)-but-3-yn-2-ol;(R)-4-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(2-trifluoromethyl- pyrimidin-4-yl)-but-3-yn-2-ol;4-(5-{(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-2-(6- methyl-pyridin-2-yl)-but-3-yn-2-ol;4-(5-{(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(1-methyl-cyclopropyl)-phenyl]-methyl}-pyridin-3-yl)-2-(6-methyl- pyridin-2-yl)-but-3-yn-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-trifluoromethyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)- but-3-yn-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-(4-ethyl-phenyl)-hydroxy-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol;4-{5-[(R)-(4-tert-Butyl-phenyl)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3- yn-2-ol;4-{5-[(R)-(3-Ethyl-1-methyl-azetidin-3-yl)-hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol;4-(5-{(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-[4-(2,2,2-trifluoro-ethyl)-phenyl]-methyl}-pyridin-3-yl)-2-(6-methyl- pyridin-2-yl)-but-3-yn-2-ol;4-{5-[(S)-(3-Fluoro-1-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)- but-3-yn-2-ol;1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-ylethynyl}-piperidin-1-yl)- ethanone;N-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-1,1 -dimethyl-prop-2- ynyl)-acetamide;1-(3-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-1,1 -dimethyl-prop-2- ynyl)-pyrrolidin-2-one;4-{5-[(R)-Hydroxy-(1-isopropyl-3-methyl-azetidin-3-yl)-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2- yl)-but-3-yn-2-ol;4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3- yn-2-ol;4-{5-[(R)-Hydroxy-[1-(2-hydroxy-ethyl)-3-methyl-azetidin-3-yl]-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl- pyridin-2-yl)-but-3-yn-2-ol;4-{5-[(R)-[1-(2,2-Difluoro-ethyl)-3-methyl-azetidin-3-yl]-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl- pyridin-2-yl)-but-3-yn-2-ol;1-(4-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yloxymethyl}-piperidin-1-yl)- ethanone;4-{5-[(R)-(1-Cyclopropyl-3-methyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-2-(6-methyl-pyridin-2-yl)-but-3-yn-2-ol;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(2-isopropyl-pyrimidin-4-yl)- pyrrolidin-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(2-methyl-thiazol-5-yl)- pyrrolidin-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(6-methyl-pyridin-3-yl)- pyrrolidin-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(6-isopropyl-pyridin-2-yl)- pyrrolidin-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(6-trifluoromethyl-pyridin-3- yl)-pyrrolidin-2-one;1 -{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(1 -methyl-1 H-pyrazol-4-yl)- pyrrolidin-2-one;1 -{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(1 ,3-dimethyl-1 H-pyrazol-4- yl)-pyrrolidin-2-one;4-(1-Difluoromethyl-1H-pyrazol-4-yl)-1-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]- pyridin-3-yl}-pyrrolidin-2-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-4-(2-methyl-2H-[1,2,3]triazol-4-yl)-pyrrolidin-2-one;4-(1-Acetyl-piperidin-4-yl)-1-{5-[(R)-(1,3-dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}- pyrrolidin-2-one;5-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-hexahydro-furo[2,3-c]pyrrol- 4-one;1-{5-[(R)-(1,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridazin-3-yl}-4-(6-isopropyl-pyridin-2-yl)- pyrrolidin-2-one;1-(2-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-7,8-dihydro-5H-pyrido[4J3- d]pyrimidin-6-yl)-ethanone; 1-(2-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-7J8-dihydro-5H-[1 ,6]naphthyridin-6-yl)-ethanone;1-[4-(2-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrimidin-5-yl)-piperidin- 1-yl]-ethanone; or1-[4-(2-{5-[(R)-(1 ,3-Dimethyl-azetidin-3-yl)-hydroxy-(4-isopropyl-phenyl)-methyl]-pyridin-3-yl}-pyrimidin-4-yl)-piperidin- 1-yl]-ethanone; or a pharmaceutically acceptable salt thereof.13 A pharmaceutical composition comprising a compound according to any one of claims 1 to 12, further comprising at least one pharmaceutically acceptable carrier.14 A compound according to any one of claims 1 to 12, for use as a medicament. 15 A compound according to any one of claims 1 to 12, for use in the prevention or treatment of inflammatory / autoimmune diseases / disorders, or cancer.