SYRINGE SUITABLE FOR HYDROGEN PEROXIDE SOLUTION AND SAME KIT

Abstract

A syringe is provided that suppresses the decomposition of hydrogen peroxide. An object of the present invention is to provide a syringe that includes a part in contact with a hydrogen peroxide solution, wherein the part is made of cycloolefin polymer (COP) or cycloolefin copolymer (COC).

Description

Field of Invention The present invention relates to a syringe, and particularly to a syringe made of a material that has a lower rate of metal ion elution in the presence of hydrogen peroxide solution compared to glass. Background of the Invention A hydrogen peroxide solution is used industrially as a bleaching agent and as a disinfectant in the food industry. A hydrogen peroxide solution containing 2.5 to 3.5% (w / v) hydrogen peroxide (known as oxidol in the Japanese Pharmacopoeia) is used for medical purposes as a disinfectant. This hydrogen peroxide solution can be used as a radiosensitizer by mixing it with a hyaluronic acid solution or a salt thereof such as sodium hyaluronate in a predetermined ratio, and then injecting the mixture into a tumor just before the therapeutic radiation dose (Patent Document 1). PREVIOUS ART DOCUMENT PATENT DOCUMENT Patent Document 1: WO2008 / 041514 QfrZfrnn / Lznz / E / YiAi Ref. 315415 Brief Description of the Invention PROBLEMS TO BE SOLVED BY THE INVENTION Since hydrogen peroxide decomposes rapidly when removed from a special light-protected storage container, it must be drawn up in the appropriate volume or weight and then mixed with the sodium hyaluronate solution just before injection when used as a radiation sensitizer, as described in patent document 1. This places an additional burden on the medical staff treating the patient. Either the hospital pharmacy must draw up the hydrogen peroxide solution and mix it with the sodium hyaluronate, or a physician must do so in the patient's room. In the first case, a burden is placed on the pharmacy staff, and there is a risk of delays in transporting the injection mixture from the pharmacy to the patient's room. In the second case, a burden is placed on the medical staff in the patient's room, who are preparing the patient for radiotherapy.In both cases, the complications of extracting and mixing the solutions increase the risk of errors that could compromise medical treatment or endanger the patient. Additionally, if the hydrogen peroxide solution is pre-filled using a syringe made of conventional glass (e.g., borosilicate glass), the syringe The glass syringe (QfrZfrnn / Lznz / E / YiAi) expands during storage of hydrogen peroxide solution, and the seal is pushed back. This can interfere with long-term storage of hydrogen peroxide solution in such a glass syringe. MEANS TO SOLVE PROBLEMS An object of the present invention is to provide a syringe including a portion thereof in contact with a hydrogen peroxide solution, wherein the portion is made of cycloolefin polymer (OOP) or cycloolefin copolymer (COC). Using a syringe helps limit the decomposition of hydrogen peroxide in the hydrogen peroxide solution. Therefore, using a pre-filled syringe allows for the extended storage of a hydrogen peroxide solution. The syringe may be suitable for being pre-filled with a hydrogen peroxide solution. The syringe may also contain the hydrogen peroxide solution. The hydrogen peroxide solution may consist of hydrogen peroxide and water. The hydrogen peroxide solution may include an additive. QfrZfrnn / Lznz / E / YiAi The syringe may also include a nozzle in a part for mounting a syringe needle. When the syringe is already equipped with a nozzle, rapid administration is possible. The nozzle may include a nozzle part and an adapter part connected to the syringe needle mounting part. The nozzle part can be a needle or a rolling nozzle. The needle may have a notch in an echogenic pattern on its outer surface. The syringe may also include a protective cover. The nozzle portion may be covered by the cover. The protector may include a support member, a nozzle protection part connected to one end of the support member, and a coupling part connected to the other end of the support member. The nozzle protection portion may include a space capable of housing the nozzle portion. The coupling part may include a movable part and may be movably connected to the other end of the support member by means of the movable part. The space may be located along the inner surface of the side wall of the nozzle protection part. The supporting member may include a first arm, QfrZfrnn / Lznz / E / YiAi a second arm, a first movable part, a second movable part and a third movable part. One end of the first arm can be movably connected to the nozzle guard by means of the first movable part. The other end of the first arm can be movably connected to one end of the second arm by means of the second movable part. One end of the second arm can be movably connected to the coupling part by means of the third movable part. The movable part may include a rail part connected to the nozzle protection part and a rail support part connected to the coupling part. The rail support part can slide the rail part in place. The space may be positioned within the nozzle protection part. The nozzle protection part may have a hollow structure. The syringe may also include a syringe pump. The concentration of hydrogen peroxide in the hydrogen peroxide solution can be from 0.01 to 40% (w / v). Another object of the present invention is to provide a kit that includes the syringe and the nozzle. By using the kit, it is not necessary to choose the QfrZfrnn / Lznz / E / YiAi syringe nozzle. As a result, rapid administration can be facilitated. The kit may also include a protector to cover the nozzle part. EFFECT OF THE INVENTION According to the present invention, a pre-filled syringe can be provided that stores hydrogen peroxide solution for an extended period until it is ready for use as a radiosensitizer. This allows for rapid administration. Furthermore, safe administration is ensured by providing a protective cover for the syringe nozzle. Using a needle as the nozzle, the hydrogen peroxide solution can be administered easily and safely. Alternatively, using a roller nozzle, the hydrogen peroxide solution can be administered easily and safely by spraying. Using a syringe pump, the pre-filled syringe can be operated reliably, delivering the pre-filled solution at a predetermined rate. Brief Description of the Figures FIG. 1 shows a schematic view of a pre-filled syringe containing a hydrogen peroxide solution according to the present embodiment. FIG. 2 shows a syringe pre-filled with a needle QfrZfrnn / Lznz / E / YiAi in accordance with the present modality. FIG. 3 shows a pre-filled syringe with a spray nozzle according to the present modality. FIG. 4 is a partially magnified cross-sectional view of the spray nozzle according to the present modality. FIG. 5 shows a pre-filled syringe with a protector according to the present modality. FIG. 6 shows a pre-filled syringe with a movable protector in the protection mode according to the present modality. FIG. 7 shows a pre-filled syringe with a movable shield in the administration mode according to the present modality. FIG. 8 shows a pre-filled syringe with a liftable protector in the protection mode according to the present modality. FIG. 9 shows a pre-filled syringe with a slide-type protector in the administration mode according to the present modality. FIG. 10 shows a pre-filled syringe equipped with a syringe pump according to the present embodiment. FIG. 11 is a schematic diagram illustrating the operation of a syringe pump according to the present modality. QfrZfrnn / Lznz / E / YiAi FIG. 12 shows a graph of residual hydrogen peroxide values ​​for each syringe material in the example. Detailed Description of the Invention Definition For convenience, certain terms used in the context of this description are included herein. Unless otherwise defined, all technical and scientific terms used herein have the same meaning commonly understood by a person skilled in the art to which the present invention pertains. The singular forms a / an and a / an are used herein to include plural referents unless the context clearly indicates otherwise. Although the numerical ranges and parameters that define the broad scope of the invention are approximations, the numerical values ​​stated in the specific examples are described as precisely as possible. Any numerical value, however, inherently contains certain errors that necessarily result from the standard deviation found in the respective test measurements. Furthermore, as used herein, the term "approximately" generally means within 10%, 5%, 1%, or 0.5% of a given value or range. Alternatively, the term "approximately" means within an acceptable standard error of the mean when considered by a person skilled in the art. "Protection mode" in this description means a state in which, by means of a guard, a tip of a nozzle portion cannot reach the skin, i.e., a state in which administration cannot be effected. "Administration mode" as used in this description means a state in which the tip of the nozzle portion is exposed from the guard, i.e., a state in which administration can be effected. The following are detailed descriptions of embodiments of the present invention. These embodiments are for illustrative purposes only and do not limit the scope of the present invention. To avoid redundancy, explanations are not repeated for similar content. Syringe A syringe according to the present embodiment includes a portion thereof in contact with a hydrogen peroxide solution, wherein the portion is made of cycloolefin polymer (COP) or cycloolefin copolymer (COC). The syringe may be suitable for pre-filling with a hydrogen peroxide solution. The syringe may also contain the hydrogen peroxide solution. The hydrogen peroxide solution may contain peroxide of QfrZfrnn / Lznz / E / YiAi hydrogen and water. The hydrogen peroxide solution may include an additive. Figure 1 shows a schematic diagram of a pre-filled syringe (1) filled with hydrogen peroxide solution (50) according to the present embodiment. In the present embodiment, a syringe (10), particularly a syringe barrel (20), is generally cylindrical. In the present embodiment, the syringe (10) has, at one end, a needle mounting portion (30) from which the hydrogen peroxide solution (50) is discharged. In the present embodiment, the syringe (10) has, at the other end, a stem portion (80) inserted for inserting a plunger stem (70). In the present embodiment, the syringe (10) has a flange (90) provided around the inserted stem portion (80). In order to seal the filled hydrogen peroxide solution (50), the pre-filled syringe (1) shown in Figure 1 has a flange (90) provided around the inserted stem portion (80).1 has a cover (40) provided over the needle mounting part (30) and the plunger stem (70) inserted from the inserted stem part (80), the plunger stem (70) having a seal (60). In this embodiment, a syringe for hydrogen peroxide solution means a syringe that has a low capacity for the decomposition of hydrogen peroxide into the hydrogen peroxide solution. In this embodiment, hydrogen peroxide solution means a solution in QfrZfrnn / Lznz / E / YiAi in which a solvent (e.g., aqua) contains hydrogen peroxide and, if necessary, additives (e.g., phosphoric acid and phenacetin, apart from gel substrate). In one embodiment, the hydrogen peroxide solution is substantially free of the gel substrate (e.g., hyaluronic acid, hyaluronic acid salt, hydrogel, and gelatin). Substantially free means, for example, that the concentration of the gel substrate is less than 0.1% by mass, less than 0.05% by mass, less than 0.01% by mass, less than 0.005% by mass or less than 0.001% by mass or less than 0.1% (w / v), less than 0.05%(w / v), less than 0.01%(w / v), less than 0.005%(w / v) or less than 0.001% (w / v). In another embodiment, the hydrogen peroxide solution does not include the gel substrate. In this embodiment, the syringe may be made from a single material or from a plurality of materials (including a multilayer structure such as a coating). In the case of the syringe made from a single material, the entire syringe is made of plastic such as COP and COC. In the case of a syringe made from a plurality of materials, the part where the syringe comes into direct contact with the hydrogen peroxide solution is made of plastic; the remaining part can be made of a material that has a high capacity for decomposing hydrogen peroxide. QfrZfrnn / Lznz / E / YiAi hydrogen peroxide, such as glass. In addition, all parts that come into contact with the hydrogen peroxide solution need to be made of plastic. Therefore, the main part, such as the inner surface of the syringe barrel, can be made of plastic. In other words, parts that may come into contact with the hydrogen peroxide solution, such as a plunger stem, luer lock, cap, and gasket, need to be made of plastic. Furthermore, a lubricant such as silicone oil can be applied to the inner surface of the syringe barrel. The decomposition capacity of hydrogen peroxide can be determined from the ratio of the hydrogen peroxide concentration in the hydrogen peroxide solution after the start of storage to the hydrogen peroxide concentration in the hydrogen peroxide solution before the start of storage under specific temperature conditions (residual hydrogen peroxide value). Storage is carried out in a sealed state. The temperature condition is not limited, but can be 35°C, 37°C, 40°C, or 60°C. The storage period is not limited, but can be one week, two weeks, three weeks, four weeks, or four weeks or more. The hydrogen peroxide concentration in the hydrogen peroxide solution before the start of storage QfrZfrnn / Lznz / E / YiAi can be any concentration, for example, within the range of 0.01 to 40% (w / v). In one embodiment, the decomposition capacity of hydrogen peroxide by plastic is less than that of glass. The residual value of hydrogen peroxide in the plastic can be 70% or more, preferably 75% or more, more preferably 78% or more, and even more preferably 80% or more, provided that a solution containing 2.5 to 3.5% (w / v) hydrogen peroxide is stored hermetically at 60°C for 4 weeks. The amount of hydrogen peroxide in the hydrogen peroxide solution can be determined by titration with a potassium permanganate solution according to a method for determining oxidol described in the Japanese Pharmacopoeia. In the present modality, the plastic may include COP, COC and a polypropylene, but is not limited to them as long as the plastic has a hydrogen peroxide decomposition capacity lower than glass. Nozzle Figure 2 shows the pre-filled syringe (1) with a nozzle (100). The nozzle (100) is attached to the needle mounting portion (30) of the pre-filled syringe (1). The nozzle (100) may be pre-assembled onto the needle mounting portion (30) of the pre-filled syringe (1) or may be included in a kit that includes the pre-filled syringe (1). When the The QfrZfrnn / Lznz / E / YiAi nozzle (100) is pre-assembled on the needle mounting part (30) of the pre-filled syringe (1). The nozzle (100) (or the pre-filled syringe (1)) preferably includes a locking mechanism that prevents the loss of hydrogen peroxide solution (50) until the pre-filled syringe (1) is used. The nozzle (100) includes a nozzle part (110) and an adapter part (120) connected to the nozzle part (110). The adapter part (120) is connected to the needle mounting part (30) of the pre-filled syringe (1). The interior of the nozzle part (110) is in fluid communication with the interior of the adapter part (120). The pre-filled syringe (1) shown in FIG. 2 includes a needle (111) as the nozzle portion (110). In another embodiment, the pre-filled syringe (1) includes a spray nozzle (112) as the nozzle portion (110) (FIG. 3). The spray nozzle (112) shown in FIG. 3 is integrally molded into the adapter portion (120). In another embodiment, the spray nozzle (112) is removably attached to the adapter portion (120). FIG. 4 shows a partially magnified cross-sectional view of the spray nozzle (112) shown in FIG. 3. The cross-sectional view in FIG. 4 represents a cross-section of the pre-filled syringe (1) shown in FIG. 3 passing through the axis QfrZfrnn / Lznz / E / YiAi central AA. The rolling nozzle (112) includes an outlet (112A), an orifice (112B), and an inlet (112C). The internal diameter of the outlet (112A), according to this embodiment, decreases from the outside of the rolling nozzle (112) towards the orifice (112B). The internal diameter of the inlet (112C), according to this embodiment, decreases from the inside of the rolling nozzle (112) towards the orifice (112B). Depending on the desired particle size of the hydrogen peroxide solution (50), the internal diameter of the orifice (112B) may be varied. The internal diameter of the outlet (112A) may be the same as the internal diameter of the orifice (112B), and the internal diameter of the inlet (112C) may be the same as the internal diameter of the orifice (112B). The internal diameter of the spray nozzle (112) can be constant. The needle (111) may have a notch with an echogenic pattern on its outer surface. The echogenic pattern is not particularly limited as long as it is the notch pattern that improves the visibility of the needle (111), even in an ultrasound image. Protective Figure 5 shows the pre-filled syringe (1) fitted with a protector (200). The protector (200) can cover the nozzle (100). The protector (200) can be removably connected to the adapter portion (120) (or the pre-filled syringe (1)) of the nozzle (100) by snapping or screwing. The protector (200) can include a locking mechanism that prevents the loss of the hydrogen peroxide solution (50) from the pre-filled syringe (1). The locking mechanism can prevent the loss of the hydrogen peroxide solution (50) from the pre-filled syringe (1), for example, by contacting the inner part of the tip of the protector (200) with the tip of the nozzle (100). Removable protector Figures 6 and 7 show the pre-filled syringe (1) equipped with a movable guard (300). The movable guard (300) shown in Figure 6 protects the nozzle portion (110). The movable guard (300) shown in Figure 7 is positioned to expose the nozzle portion (110). The movable guard (300) includes a support member (320), a nozzle guard portion (310) connected to one end (321) of the support member (320), and a coupling portion (330) connected to the other end (322) of the support member (320). The coupling portion (330) is connected to the other end (322) of the support member (320) by means of the movable portion (340). The coupling portion (330) is removably connected to the adapter portion (120). The nozzle guard (310) of the movable guard (300) has a space that can accommodate the nozzle portion (110) of the nozzle (100) within the nozzle guard (310). In the present embodiment, the space is a notch (311). The notch (311) is formed in a side wall (314) of the nozzle guard (310). A front end (312) of the nozzle guard (310) is closed. A rear end (313) of the nozzle guard (310) is open. The movable guard (300) can expose the nozzle portion (110) of the nozzle (100) from the notch (311) of the nozzle guard portion (310) by rotating the movable guard (300) around the movable portion (340) as a rotation axis without physically separating the movable guard (300) from the adapter portion (120) and vice versa. The movable shield (300) may include a plurality of support members (320). When the movable shield (300) includes a plurality of support members (320), each support member (320) may be connected by a movable part. The coupling part (330) may be coupled with the adapter part (120) of the nozzle (100) or the pre-filled syringe (1). In the present embodiment, the movable part (340) is a pivot part including a shaft, but is not limited to it. The movable part (340) may be a bent part capable of bending. When the movable part (340) is the bent part, the support member (320) and the coupling part (330) QfrZfrnn / Lznz / E / YiAi can be integrally formed. Slide-type protector Figures 8 and 9 show the pre-filled syringe (1) fitted with a slide-type protector (400). The slide-type protector (400) shown in Figure 8 protects the nozzle portion (110). The slide-type protector (400) shown in Figure 9 is positioned to expose the nozzle portion (110). The slide-type guard (400) includes a support member (420), a nozzle guard portion (410) connected to one end of the support member (420), and a coupling portion (430) connected to the other end of the support member (420). The coupling portion (430) is removably connected to the adapter portion (120). The support member (420) includes a first arm (421), a second arm (422), a first movable portion (441), a second movable portion (442), and a third movable portion (443). In the present embodiment, the nozzle guard portion (410) has a hollow structure and a space that can accommodate a front end of the nozzle portion (110) from a rear end (413) of the nozzle guard portion (410). When the slide-type guard (400) is in a guard mode, the front end of the nozzle part (110) is housed in the nozzle guard part (410).When the protector is a sliding type. QfrZfrnn / Lznz / E / YiAi (400) is in a management mode, the front end of the nozzle part (110) protrudes from an opening (411) in the nozzle guard part (410). In the present mode, the opening (411) is cross-shaped, but it may have another shape. One end (421A) of the first arm (421) is movably connected to the nozzle guard portion (410) by means of the first movable part (441). The other end (421B) of the first arm (421) is movably connected to one end (422A) of the second arm (422) by means of the second movable part (442). The other end (422B) of the second arm (422) is movably connected to the coupling portion (430) by means of the third movable part (443). By rotating each arm around the central axis of each movable part so that the second movable part (442) is away from the nozzle (100), the nozzle guard part (410) can be moved in the direction of the adapter part (120), resulting in the nozzle part (110) of the nozzle (100) being exposed from the opening (411) of the nozzle guard part (410) without physically separating the slide-type guard (400) from the adapter part (120) and vice versa. The number of arms and the number of moving parts can be modified as needed. The arm length can be modified according to the part length (110). QfrZfrnn / Lznz / E / YiAi of nozzle. Another option In another embodiment, the slide-type protector (400) includes a rail portion, a nozzle guard portion (410) connected to one end of the rail portion, and a rail support portion connected to the other end of the rail portion. The rail support portion slides into the rail portion. The rail support portion is removably connected to the adapter portion (120). The opening (411) is provided at the front end of the nozzle guard portion (410). By sliding the nozzle guard portion (410) longitudinally along the pre-filled syringe (1), the nozzle portion (110) can be engaged in or exposed through the opening (411). Syringe pump FIG. 10 shows the pre-filled syringe (1) equipped with a syringe pump (500). The syringe pump (500) in the present embodiment includes grooves (510) into which one end of the flange (90) of the pre-filled syringe (1) is inserted, a holder (520) that secures the pre-filled syringe (1), a movable wall (530) that pushes the plunger rod (70) of the pre-filled syringe (1), a monitor (540), switches (550), a processor (560), a memory (561), a pressure sensor (562), a battery (563), and an electric motor (564). The monitor (540) and switches (550) are provided on the first surface (501A) of the syringe pump (500). The movable wall (530) is provided on the second surface (501B) of the syringe pump (500). The second surface (501B) of the syringe pump (500) is provided in a lower position than the first surface (501A) of the syringe pump (500). The first surface (501A) of the syringe pump (500) is connected to the second surface (501B) of the syringe pump (500) by means of the first wall (502A) of the syringe pump (500). The slots (510) are formed so as to pass through the first surface (501A) and the first wall (502A) of the syringe pump (500). The movable wall (530) is connected to two threaded rods (570A) and (570B) provided on the second surface (501B). When the threaded rods (570A) and (570B) are rotated by, for example, the electric motor (564), the movable wall (530) can move in the direction of pushing (or pulling) the plunger rod (70) of the pre-filled syringe (1). The movable wall (530) of the syringe pump (500) is electrically driven, but it can also be mechanically driven. When using the syringe pump (500), one end of the flange (90) of the pre-filled syringe (1) is inserted into any one of the slots (510). When inserting a QfrZfrnn / Lznz / E / YiAi The end of the flange (90) of the pre-filled syringe (1) is inserted into the groove (510), preventing movement of the pre-filled syringe (1) in the direction of movement of the movable wall (530). Depending on the length of the pre-filled syringe (1), any one of the grooves (510) can be selected. The pre-filled syringe (1) is further secured by the clamp (520). The clamp (520) is configured to press the pre-filled syringe (1) against the first wall (502A) and the second surface (501B). Securing the pre-filled syringe (1) using the clamp (520) prevents it from falling out of the syringe pump (500). The operation of the syringe pump (500) will be described with reference to FIG. 11. The syringe pump (500) is powered by a battery (563). The operation of the syringe pump (500) can be configured by operating the switches (550). Requests from the switches (550) are processed by the processor (560). The processor (560) can read necessary information (such as a program) from memory (561) upon receiving a request and can store the necessary information in memory (561). The processor (560) can display a processing result on the monitor (540). When the processor (560) receives a request to move the syringe pump (500), it processes the request so that the electric motor (564) rotates. Based on the information from the pressure sensor (562) connected to the movable wall (530), the processor (560) can process the information in such a way that the electric motor (564) stops. The syringe pump (500) can set a flow rate, administration time, syringe internal diameter, pressure threshold and the like, thus allowing for stable administration. Kit In yet another modality, a kit is provided that includes: the syringe and the nozzle. The kit includes the pre-filled syringe (1) and the nozzle (100). The kit may include a plurality of pre-filled syringes (1) and nozzles (100). The kit may include the protective cover (200), (300), or (400) that covers the nozzle (100). The kit may include additional items (e.g., instructions or dosage schedules) for the treatment of tumors with anticancer drugs or radiation. In the present embodiment, the concentration of hydrogen peroxide in the hydrogen peroxide solution in the pre-filled syringe is, for example, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.5, 1, 5, 10, 15, 20, 25, 30, 35 or 40%, or may be within the range of any two of the numerical values ​​exemplified herein, for example, 0.01 to 40% (w / v), preferably 0.05 to 30% (w / v). Material The material of the nozzle part (110) may be changed according to the purpose and usage of this embodiment. When the nozzle part (110) is the needle (111), the material of the nozzle part (110) (i.e., the needle (111)) may be a metal such as stainless steel. The material of the adapter part (120) may be a resin (e.g., COP, COC, polypropylene, and polycarbonate), metal, rubber, or glass. When the nozzle part (110) is the spray nozzle (112), the material of the nozzle part (110) (i.e., the spray nozzle (112)) may be a resin (e.g., COP, COC, polypropylene, and polycarbonate), metal, rubber, or glass. When the spray nozzle (112) is integrally formed with the adapter part (120), the same material as that of the adapter part (120) is used. The material of the protector (200) may include, but is not limited to, resins (for example, COP, COC, polypropylene, and polycarbonate), metal, rubber, and glass. The material of the movable protector (300) and the slide-type protector (400) may be the same as the material of the protector (200). The material of the movable parts of the movable protector (300) and the slide-type protector (400) (the movable part (340), first movable part (441), second movable part (442), and QfrZfrnn / Lznz / E / YiAi third movable part (443)) may be different from the material of other parts of the movable protector (300) and the sliding-type protector (400) depending on the purpose and situation of use of the present modality. A syringe pump housing (500) can be made of metal or resin (for example, polycarbonate). The movable wall material (530) can be the same as or different from the syringe pump housing material (500). The fastener (520) can be made of metal, rubber, or resin. The threaded rods (570A) and (570B) are preferably made of metal, but can be made of resin. EXAMPLES Hydrogen peroxide solution stability test A stability test of a hydrogen peroxide solution was performed using a glass syringe, a COP syringe, and a COC syringe. One milliliter of the hydrogen peroxide solution was added to each syringe, sealed, and then stored at 60°C for 4 weeks. Residual hydrogen peroxide levels in the hydrogen peroxide solutions were measured after storage. KENEI Oxidol (containing 2.5 to 3.5% (w / v) hydrogen peroxide, phosphoric acid, and phenacetin), manufactured by Kenei Pharmaceutical Co., Ltd., was used as the hydrogen peroxide solution. The amount of hydrogen peroxide in the hydrogen peroxide solution QfrZfrnn / Lznz / E / YiAi was detected by titration with a potassium permanganate solution according to the method for determining oxide1 described in the Japanese Pharmacopoeia. The results are shown in FIG. 12. In the case of glass, the residual value of hydrogen peroxide was less than 70%, while the residual value for COP and COC was 70% or more. As a result, the COP and COC syringes were more effective at suppressing hydrogen peroxide decomposition than the glass syringe. EXPLANATION OF REFERENCES Pre-filled syringe Syringes Barrel Needle assembly part 0 Cover Hydrogen peroxide solution Board 70Piston rod Inserted stem portion Flange 100 Nozzle 110 Nozzle part 111 Needle 112 Rolling nozzle 112A Exit 112B Hole 112C Entrance 120 Adapter part 200 Protector 300 Movable Protector 310 Nozzle protection part 311 Notch 312 Front end of nozzle protection part 313 Rear end of nozzle protection part 314 Side wall of the nozzle protection part 320 Support Member 321 One end of the support member 322 Other end of the support member 330 Coupling part 340 Movable part 400 Sliding type protector 410 Nozzle protection part 411 Opening 412 Front end of nozzle protection part 413 Rear end of nozzle protection part QfrZfrnn / Lznz / E / YiAi 420 Support member 421 First arm 421A One end of the first arm 421B Another end of the first arm 5 422 Second arm 422A One end of the second arm 422B Another end of the second arm 430 Coupling part 441 First movable part 10 442 Second movable part 443 Third movable part 500 Syringe pump 501A First surface of the syringe pump 501B Second surface of the syringe pump 15 502A First wall of the syringe pump 510 Slot 520 Clamp 530 Movable wall 540 Monitor 20 550 Switch 560 Processor 561 Memory 562 Pressure sensor 563 Battery 25 564 Electric motor 570A, 570B Threaded rod It is hereby stated that, as of this date, the best method known to the applicant for putting the aforementioned invention into practice is the one that is clear from the present description of the invention.

Claims

1. A syringe characterized in that it comprises a portion thereof in contact with a hydrogen peroxide solution, wherein the portion is made of cycloolefin polymer (COP) or cycloolefin copolymer (COC).

2. The syringe according to claim 1, characterized in that the syringe is suitable for being pre-filled with a hydrogen peroxide solution.

3. The syringe according to claim 2, characterized in that it further comprises the hydrogen peroxide solution in the syringe, wherein the hydrogen peroxide solution comprises hydrogen peroxide and water.

4. The syringe according to claim 3, characterized in that it further comprises an additive.

5. The syringe according to any of claims 1 to 4, characterized in that it further comprises a nozzle in a needle mounting portion of the syringe.

6. The syringe according to claim 5, characterized in that the nozzle comprises a nozzle portion and an adapter portion connected to the syringe needle assembly portion, and the nozzle portion is either a needle or a spray nozzle.

7. The syringe according to claim 6, characterized in that the needle has a notch with an echogenic pattern on an outer surface thereof.

8. The syringe according to claim 6 or 7, characterized in that it further comprises a protector, wherein the nozzle portion is covered with the protector.

9. The syringe according to claim 8, characterized in that the protector comprises a support member, a nozzle protection part connected to one end of the support member; and a coupling part connected to the other end of the support member, and the nozzle protection part comprises a space capable of accommodating the nozzle part.

10. The syringe according to claim 9, characterized in that the coupling part comprises a movable part and is movably connected to the other end of the support member by means of the movable part.

11. The syringe according to claim 9 or 10, characterized in that the space is positioned on a side wall of the nozzle protection part.

12. The syringe according to claim 9, characterized in that the support member comprises a first arm, a second arm, a first movable part, a second movable part and a third movable part, one end of the first arm being movably connected to the nozzle protection part by means of the first movable part, the other end of the first arm being movably connected to one end of the second arm by means of the second movable part, and the other end of the second arm being movably connected to the coupling part by means of the third movable part.

13. The syringe according to claim 10, characterized in that the movable part comprises a rail part connected to the nozzle protection part and a rail support part connected to the coupling part, and the rail support part slideably supports the rail part.

14. The syringe according to claim 12 or 13, characterized in that the space is positioned within the nozzle protection part, and the nozzle protection part has a hollow structure.

15. The syringe according to any of claims 1 to 14, characterized in that it further comprises a syringe pump.

16. The syringe according to any of claims 1 to 15, characterized in that the concentration of hydrogen peroxide in the hydrogen peroxide solution is 0.01 to 40% (w / v).

17. A kit characterized in that it comprises: the syringe according to claim 1 and a nozzle.

18. The kit according to claim 14, characterized in that it further comprises a protector to cover the nozzle part.