Peptide-conjugate vaccine compositions and methods for the treatment of alzheimer's disease

Abstract

The invention provides compositions and methods for treating diseases associated with amyloid deposits of Aβ in the brain of a patient, such as Alzheimer's disease. These methods involve administering a pharmaceutical composition comprising an immunogenic fragment of Aβ capable of inducing a beneficial immune response in the form of antibodies against Aβ. The immunogenic fragments comprise linear or multivalent peptides of Aβ. Pharmaceutical compositions comprise the immunogenic fragment chemically bound to a carrier molecule that can be administered with an adjuvant.