Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

Abstract

The present invention provides improved and / or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens. In particular, the invention provides, tumour infiltrating lymphocytes (TILs) in a pharmaceutical composition with a pharmaceutical carrier that comprises 1.5 x10^9 to 1.5 x10^10 expanded TILs in a population that possesses the same or similar properties as larger populations including an ability to exhibit increased IFN-y by at least one-fold.

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