Methods and compositions for reducing the immunogenicity of chimeric notch receptors
NZ797176BActive Publication Date: 2026-09-29CELL DESIGN LABS INC
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Patent Information
- Application Number
- NZ797176
- Authority / Receiving Office
- NZ · NZ
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2017-09-11
- Filing Date
- 2018-06-19
- Publication Date
- 2026-09-29
- Estimated Expiration
- 2038-06-19
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Figure 1_ABST
Abstract
The present invention relates to methods and compositions for reducing the immunogenicity of chimeric Notch receptors, which can be genetically engineered in cells of the monocyte / macrophage lineage for drug delivery. Specifically, the invention relates to transcription factors useful for controlling gene expression delivered to tissues by such chimeric Notch receptors. The transcriptional regulator comprises a DNA binding domain of human origin and a transactivation domain of human origin.
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