Methods and compositions for reducing the immunogenicity of chimeric notch receptors

NZ797176BActive Publication Date: 2026-09-29CELL DESIGN LABS INC
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Patent Information

Application Number
NZ797176
Authority / Receiving Office
NZ · NZ
Patent Type
Patents
Current Assignee / Owner
Priority Date
2017-09-11
Filing Date
2018-06-19
Publication Date
2026-09-29
Estimated Expiration
2038-06-19

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Abstract

The present invention relates to methods and compositions for reducing the immunogenicity of chimeric Notch receptors, which can be genetically engineered in cells of the monocyte / macrophage lineage for drug delivery. Specifically, the invention relates to transcription factors useful for controlling gene expression delivered to tissues by such chimeric Notch receptors. The transcriptional regulator comprises a DNA binding domain of human origin and a transactivation domain of human origin.
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