Multispecific polypeptide constructs having constrained CD3 binding and methods of using the same
NZ798584BActive Publication Date: 2026-09-29INHIBRX BIOSCIENCES INC
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Patent Information
- Application Number
- NZ798584
- Authority / Receiving Office
- NZ · NZ
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2017-04-11
- Filing Date
- 2018-04-11
- Publication Date
- 2026-09-29
- Estimated Expiration
- 2038-04-11
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Abstract
The disclosure relates generally to multispecific polypeptides having constrained CD3 binding. In some embodiments, the multispecific polypeptides contain cleavable linkers that, when cleaved, results in dual effector functions. Also provided are methods of making and using these multispecific polypeptides in a variety of therapeutic, diagnostic and prophylactic indications.
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