Methods and compositions for reducing the immunogenicity of chimeric notch receptors

NZ800886BActive Publication Date: 2026-09-01CELL DESIGN LABS INC
View PDF 0 Cites 0 Cited by

Patent Information

Application Number
NZ800886
Authority / Receiving Office
NZ · NZ
Patent Type
Patents
Current Assignee / Owner
Priority Date
2017-09-11
Filing Date
2018-06-19
Publication Date
2026-09-01
Estimated Expiration
2038-06-19

Smart Images

  • Figure 00000090_0000
    Figure 00000090_0000
  • Figure 00000091_0000
    Figure 00000091_0000
  • Figure 00000092_0000
    Figure 00000092_0000
Patent Text Reader

Abstract

The present invention relates to methods and compositions for reducing the immunogenicity of chimeric Notch receptors, which can be genetically engineered in cells of the monocyte / macrophage lineage for drug delivery. Specifically, the invention relates to transcription factors useful for controlling gene expression delivered to tissues by such chimeric Notch receptors. The transcriptional regulator comprises a DNA binding domain of human origin and a transactivation domain of human origin.
Need to check novelty before this filing date? Find Prior Art