Formulations for staphylococcus aureus vaccine
Patent Information
- Application Number
- NZ834888
- Authority / Receiving Office
- NZ · NZ
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-01-12
- Filing Date
- 2025-01-10
- Publication Date
- 2025-07-17
AI Technical Summary
Liquid formulations of Staphylococcus aureus vaccines are not compatible with the lack of cold chain storage infrastructure in low-to-middle income countries, necessitating the development of stable vaccine formulations that can withstand varying temperatures and maintain immunogenicity.
Development of lyophilized and spray freeze-dried formulations of Staphylococcus aureus vaccine comprising multicomponent vaccines with specific components and stabilizers like sucrose and polysorbate 80, which maintain long-term stability and immunogenicity even at varying temperatures.
The formulations exhibit reduced protein aggregation and degradation, retaining at least 70-95% of initial immunogenic activity after storage at various temperatures for up to 24 months, effectively providing protection against Staphylococcus aureus infections.
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