Process for making an isoxazoline compound and intermediate thereof

Abstract

The present disclosure provides processes for making enantiomerically pure isoxazoline compounds of formula (1),(1). The present disclosure also provides processes for making enantiomerically pure isoxazoline compounds of formula (1) characterized by improving the enantiomeric purity of 3-methyl-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]thiophene-2-carboxylic acid by crystallization.