Modified porcine pancreatic elastase proteins

NZ836104APending Publication Date: 2026-08-28ONCHILLES PHARMA INC

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Patent Information

Application Number: NZ836104
Authority / Receiving Office: NZ · NZ
Patent Type: Applications
Current Assignee / Owner
Priority Date: 2020-08-18
Filing Date: 2021-08-18
Publication Date: 2026-08-28

Application Information

Patent Timeline

18 Aug 2020

Priority

18 Aug 2021

Application

NZ836104

28 Aug 2026

Publication

NZ836104A

IPC: A61K38/00; C12N9/00; C12N15/00; C12N15/09; C12N15/52

Inventors: PETRASSI, HANK MICHAEL JAMES

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Abstract

Provided are modified porcine pancreatic elastase (PPE) proteins, including proproteins, comprising at least one amino acid alteration that reduces binding to serine protease inhibitors such as alpha-1 antitrypsin (A1AT), thereby increasing cancer-cell killing activity, and related pharmaceutical compositions and methods of use for treating diseases such as cancers.

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