Improved process of preparing mrna-loaded lipid nanoparticles

NZ837310APending Publication Date: 2026-09-25TRANSLATE BIO INC

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Patent Information

Application Number: NZ837310
Authority / Receiving Office: NZ · NZ
Patent Type: Applications
Current Assignee / Owner
Priority Date: 2020-10-12
Filing Date: 2021-10-12
Publication Date: 2026-09-25

Application Information

Patent Timeline

12 Oct 2020

Priority

12 Oct 2021

Application

NZ837310

25 Sep 2026

Publication

NZ837310A

IPC: A61K9/127; A61K9/51; A61K38/00; A61K39/00; C12N15/88

Inventors: DEROSA, FRANK; GILLIS, KIMBERLY

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Abstract

The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing an mRNA solution containing low citrate concentration and a lipid solution at an ambient temperature. Thus, the present invention provides an effective, reliable, energy-saving and cost-effective method of encapsulating mRNA into lipid nanoparticles.

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