Peptide having activity of alleviating dry eye disease and uses thereof.

Abstract

The peptide of the present disclosure has a binding capacity to PACIR, promûtes activation of a PACIR signaling pathway, and induces neuroblast differentiation, thereby having a tear secretion promoting activity. In addition, the peptide of the présent disclosure promotes expression and secretion of mucin which is a tear component in conjunctival goblet cells, and has an activity of inhibiting inflammatory response and cell damage in human corneal epithelial cells. The peptide of the présent disclosure may be used as an active material for treatment, prévention, and irrprovement of dry eye disease. Fig. 7A