Aqueous suspensions of submicron 9-hydroxyrisperidone fatty acid esters

Abstract

The present invention is concerned with a pharmaceutical composition suitable as a depot formulation for administration via intramuscular or subcutaneous injection, comprising (1) as an active ingredient a therapeutically effective amount of a 9-hydroxy-rispendone fatty acid ester or a salt, or a stereoisomer or a stereoisomeric mixture thereon in submicron form and (2) a pharmaceutically acceptable carrier; wherein the pharmaceutically acceptable carrier is water and the active ingredient is suspended therein and with a process of preparing such a composition. The invention further concerns such a pharmaceutical composition for use as a medicament in the treatment of psychosis, schizophrenia, schiioaffective disorders, non schizophrenic psychoses, behavioural disturbances associated with neurodegenerative disorders, e.g. in dementia, behavioural disturbances in mental retardation and autism, Tourette's syndrome, bipolar mania, depression, anxiety.