Biaryl derivative, preparation method thereof and pharmaceutical application thereof

Abstract

Disclosed are a biaryl derivative having a structure represented by Formula (I) and inhibitory activity against PD-1 / PD-L1 interaction, a preparation method thereof, and a pharmaceutical application thereof. The series of compounds of the present invention can be widely applied to the preparation of a medicament for preventing and / or treating cancer or tumors, immune-related diseases and disorders, contagious diseases, infectious diseases or metabolic diseases that are mediated by a PD-1 / PD-L1 signaling pathway, and shows promise for the development of a new generation of PD-1 / PD-L1 inhibitors.