ANTIBODY FC REGION HAVING ENHANCED BINDING AFFINITY TO FcyRIIB
PH12022551355B1Active Publication Date: 2026-08-14SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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Patent Information
- Application Number
- PH12022551355
- Authority / Receiving Office
- PH · PH
- Patent Type
- Patents
- Current Assignee / Owner
- Filing Date
- 2022-06-02
- Publication Date
- 2026-08-14
- Estimated Expiration
- 2042-06-02
Abstract
Provided is a modified Fc region. The Fc region has at least one amino acid mutation with respect to a parent Fc region. The modified Fc region has improved affinity to FcγRIIB with respect to the affinity of the parent Fc region to FcγRIIB. Also provided is an antibody containing the modified Fc region, especially an agonistic antibody. The modified Fc region has significant use for optimizing the agonistic activity of the antibody.
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