Multispecific heavy chain antibodies with modified heavy chain constant regions

Abstract

Multispecific, human heavy chain antibodies (e.g., UniAbsTM) that have modified heavy chain constant regions that impart advantageous properties are provided. The invention further concerns methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat disorders that are characterized by expression of one or more of the binding targets described herein.