Tricyclic carboxamide derivatives as PRMT5 inhibitors

PH12023551425B1Active Publication Date: 2026-08-12AMGEN INC

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Patent Information

Application Number: PH12023551425
Authority / Receiving Office: PH · PH
Patent Type: Patents
Current Assignee / Owner
Filing Date: 2023-05-23
Publication Date: 2026-08-12
Estimated Expiration: 2043-05-23

Application Information

Patent Timeline

23 May 2023

Application

PH12023551425

12 Aug 2026

Publication

PH12023551425B1

Inventors: AMEGADZIE, Albert; BEYLKIN, Diane Jennifer

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Abstract

Described herein are compounds of Formula I and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula I have the following structure:

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