Process for preparing new tiotropium iodide salt and pharmaceutical composition comprising thereof

Abstract

The invention relates to a process for preparing new tiotropium salt of formula 1 wherein X denotes an anion, characterised in that a tiotropium salt of formula 2 wherein Y denotes an anion other than X-selected from the group consisting of halide, C1-C10-alkylsulphonate, C1-C10-alkylsulphate, C6-C10-arylsulphonate, is reacted in a suitable solvent with an ion source Kat-X wherein Kat denotes a cation and X may have the meanings given above, and pharmaceutical formulation containing them and their use for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.