Substituted biphenyl-4-sulfonyl decahydroisoquinoline compound

Abstract

Compound of the formula I is suitable for producing pharmaceutIcal for the propylaxis and therapy of diseases whose course involves an increase in the activity of matrix metalloproteinases. These diseases include diseases such as degenerative joint disease, for example osteoarthroses, spondyloses and chondrolysis following joint trauma or a relatively long period of joint immobilization following meniscus injuries or patella injuries or ligament ruptures, or a disease of the connective tissue such as collagenoses, periodontal diseases, wound healing disturbances, or a chronic disease of the locomotory apparatus such as inflammatory, immunologically determined or metabolism-determined acute or chronic arthritides, arthropathies, myalgias or disturbances of bone metabolism, or an ulceration, atherosclerosis or stenosis or an inflammatory disease or a cancer disease, tumor metastases formation, cachexia, anorexia or septic shock.