Fluoro and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production

Abstract

Compound of Formula (I), are provided where T is CHO, COR8, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substituted alkenyl, or optionally substituted alkynyl; R3 is hydrogen or optionally substituted lower alkyl; R4 is (CF3)n alky1, (CF3)n(substitutedalkyl), (CF3)n alky1pheny1, (CF3)n alkyl(substitutedphenyl), or (F)n cycloalkyl; n=1-3; R5 is hydrogen, halogen, CF3, diene fused to Y when Y=C, or substituted diene fused to Y when Y=C; W, Y and Z are C, CR6 or N where at least one of W, Y or Z are C; R6 is hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO2, or NR7, R7 is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R8 is lower alkyl, CF3, or optionally substituted phenyl. Method of preparing and using the compound for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.