Substituted dihydro[1,8]naphthyridine-3-carboxylic acid

Abstract

The invention relates to an anticancer compound of formula (I) in which: • R1 represents a (C3-C7)cycloalkyl or (C1-C6)alkyl group optionally substituted with -NRaRb; • • A represents —NR2R3; B represents —NR4R8 or —0R6; • R5 represents H or a (C1-C4)alkyl group; • Z represents N or CH and Z' represents N or CH if Z represents N, and CH if Z represents CH; • R7 represents H or a (C1-C4)alkyl group; • L represents a —CH=CH-, — CH2CH2-, -CH2CH[NHC(=0)0(C1 C4)alkyl] or —(CH2)n-Y¬group (n=1-4 and Y = O or NR8 where R5 represents H or a (C1-C4)alkyl group); Ar represents a group chosen from: