8-(3-amino-piperidin-1-yl)-xanthines compound and pharmaceutical composition comprising thereof:

Abstract

The invention relates a compound of general formula (I) or an enantiomer or salt thereof in which R1 is a phenylcarbonylmethyl, benzyl, naphthylmethyl, pyridinylmethyl, pyrimidinylmethyl, quinolinylmethy, isoquinolinylmethyl, quinazolinylmethyl, quinoxalinylmethyl, naphthyridinylmethyl or phenanthridinylmethyl group in which the aromatic or heteroaromatic moiety is in each case mono- or disubstituted by Ra, where the substituents may be the same or different and Ra is a hydrogen, fluorine, chlorine or bromine atom or a cyano, methyl, trifluoromethyl, ethyl, phenyl, methoxy, difluoromethoxy, trifluoromethoxy or ethoxy group, or two Ra radicals, when they are bonded to adjacent carbon atoms, may also be an -0 CH2-0- or -0-CH2-CH2-0- group, R2 is a methyl, ethyl, propyl, isopropyl, cyclopropyl or phenyl group and R3 is a 2-buten-1-yl, 3-methy1-2-buten-1-yl, 2-butyn-1-yl, 2-fluorobenzyl, 2chlorobenzyl, 2-bromobenzyl, 2 iodobenzyl, 2-methylbenzyl, 2 (trifluoromethyl) benzyl or 2-cyanobenzyl group, and pharmaceutical composition comprising thereof.