A composition comprising an antigen binding region for Antibodies of dickkopf (dkk1)
PK141073AUndetermined Publication Date: 2011-01-17NOVARTIS AG
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Patent Information
- Application Number
- PK200700023
- Authority / Receiving Office
- PK · PK
- Patent Type
- Applications
- Current Assignee / Owner
- Publication Date
- 2011-01-17
Abstract
Antibodies and fragments that bind to the protein target Dickkopf (DKKI) are provided, for treating a target cell, in particular, a cell associated with an osteolytic condition. More specifically, disclosed is a composition comprising an antigen-binding region that specifically binds an epitope in a DKK1 polypeptide (SEQ ID NO: 1) and / or in a DKK4 polypeptide (SEQ ID: 124), wherein the antibody or functional fragment thereof binds to at least one epitope in DKKI or DKK4, or both.
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