Antimicrobial quinoline, its composition and use

Abstract

A compound having the following formula: wherein: (a) X is selected from (b) R1 is selected from C3 to C5 cycloalkyl, C1 to C2 alkanyl, C2 to C3 linear aIkenyl, C3 to C4 branched alkanyl or alkenyl, all such alkyl or cycloalkyl moieties being unsubstituted or substituted with from 1 to 3 fluoro; and phenyl, unsubstituted or substituted with from 1 to 3 fluoro, or with one hydroxy in the 4- position; (c) R3 is hydrogen or hydroxy (d) R5 is selected from hydrogen, hydroxy, amino, halo, C1 to C2 alkanyl, C2 alkenyl, and methoxy, all such alkyl and methoxy moieties being unsubstituted or substituted with from 1 to 3 fluoro; (e) R6 is selected from hydrogen, hydroxy, aminocarbonyl, bromo, cyano, C1 to C2 alkanyl, C2 to C4 alkettyl or alkynyl, all such alkyl moieties being unsubstituted or substituted with from 1 to 3 fluoro, or such methyl or ethyl moieties being optionally substituted with one hydroxy or amino; (f) R8 is selected from chloro, bromo, methoxy, methylthio, C1 to C2 alkanyl, C2 to C4 alkenyt, all such alkyl, methoxy and methylthio moieties being unsubstituted or substituted with from 1 to 3 fluoro; (8) R7 is amino which is attached to a ring carbon of X which is not adjacent to the ring nitrogen, the amino being unsubstituted or substituted with one or two C1 to C3 alkanyl; or aminoalkanyl which is attached to any ring carbon of X and is C1 to C3 alkanyl substituted with one amino, the amino being unsubstituted or substituted with one or two C1 to C3 alkanyl; (h) each R9 is independently selected from hydrogen, C1 to C4 alkanyl, C2 to C6 alkenyl or alkynyl, and a C3 to C6 fused or spirocycle alkyl ring, all such alkyl moieties being unsubstituted or substituted with from 1 to 3 fluoro; and (j) a R7 moiety described in (g) and a R9 moiety described in (h) may optionally be connected thus forming a fused or spirocycle ring with the N-containing ring shown in (a), the fused or spirocycle ring comprising from 2 to 5 ring carbons and 0 or 1 ring nitrogen, but if such rings are .fused. R8 is other than chloro or bromo.