A pharmaceutically acceptable sodium salt of the compound cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid

Abstract

A pharmaceutically acceptable sodium salt of the compound of Formula I wherein: m is 0 or 1; Z represents halogen, CN, NO2, N3, CF3, OR2a, N(R2a)2, CO2R2a, OCOR2a, COR2a, CON(R2a)2, OCON(R2a)2, CONR2a(OR2a), CON(R2a)N(R2a)2, CONHC(=NOH)R2a, heterocyclyl, phenyl or heteroaryl, said heterocyclyl, phenyl or heteroaryl bearing 0-3 substituents selected from halogen, CN, NO2, CF3, OR2a, N(R2a)2, CO2R2a, COR2a, CON(R2a)2 and C1-4alky1; R1b represents H, C1-4alkyl or OH; R1c represents H or C1-4alkyl; with the proviso that when m is 1, R1b and R1c do not both represent Ar1 represents C6-10aryl or heteroaryl, either of which bears 0-3 substituents independently selected from halogen, CN, NO2, CF3, OH, OCF3, C1-4alkoxy or C1-4a1kyl which optionally bears a substituent selected from halogen, CN, NO2, CF3, OH and C1-4alkoxy; Ar2 represents C1-10aryl or heteroaryl, either of which bears 0-3 substituents independently selected from halogen, CN, NO2, CF3, OH, OCF3, C1-4alkoxy or C1-4alkyl which optionally bears a substituent selected from halogen, CN, NO2, CF3, OH and C1-4alkoxy; R2a represents H, C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-6alkyl, C2-6alkenyl, any of which optionally bears a substituent selected from halogen, CN, NO2, CF3, OR2b, CO2R2b, N(R2b)2, CON(R2b)2, Ar and COAr; or R2a represents Ar; or two R2a groups together with a nitrogen atom to which they are mutually attached may complete an N-heterocyclyl group bearing 0-4 substituents independently selected from =O, =S, halogen,C1-4alkyl, CN, NO2, CF3, OH, C1-4alkoxy, C1-4alkoxycarbonyl, CO2H, amino, C1-4a1kylamino, di(C1-4alkyl)amino, carbamoyl, Ar and COAr; R2b represents H, C1-6a1kyl, C3-6cycloalkyl, C3-6cycloalkylC1-6alkyl, C2-6alkenyl, any of which optionally bears a substituent selected from halogen, CN, NO2, CF3, OH, C1-4alkoxy, C1-4alkoxycarbonyl, CO2H, amino, C1-4alky1amino, di(C1-4alkyl)amino, carbamoyl, Ar and COAr; or R2b represents Ar; or two R2b groups together with a nitrogen atom to which they are mutually attached may complete an N-heterocyclyl group bearing 0-4 substituents independently selected from =0, =S, halogen, C1-4alkyl, CN, NO2, CF3, OH, C1-4a1koxy, C1-4alkoxycarbonyl, CO2H, amino, C1-4alkylamino, di(C1-4alkyl)anaino, carbamoyl, Ar and COAr; Ar represents phenyl or heteroaryl bearing 0-3 substituents selected from halogen, C1-4alkyl, CN, NO2, CF3, OH, C1-4a1koxy, C1-4alkoxycarbonyl, amino, C1-4a1kylarnino, di(C1-4alkyl)amino, carbamoyl, C1-4alkylcarbamoyl and di(C1-4alkyl)carbamoyl; "heterocycly1" at every occurrence thereof means a cyclic or polycyclic system of up to 10 ring atoms selected from C, N, 0 and S, wherein none of the constituent rings is aromatic and wherein at least one ring atom is other than C; and "heteroaryl" at every occurrence thereof means a cyclic or polycyclic system of up to 10 ring atoms selected from C, N, 0 and S, wherein at least one of the constituent rings is aromatic and wherein at least one ring atom of said aromatic ring is other than C; or a pharmaceutically acceptable salt thereof.