Variant of a wild-type staphylokinase (Sak42D, Sakcǿc* or Sakstar)
PK141118AUndetermined Publication Date: 2011-02-19THROMBO GENICS NV
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Patent Information
- Application Number
- PK200801179
- Authority / Receiving Office
- PK · PK
- Patent Type
- Applications
- Current Assignee / Owner
- Publication Date
- 2011-02-19
Abstract
The present invention relates to an optimized thrombolytically or fibrinolytically active staphylokinase variant exhibiting low T-cell immunogenicity and reduced clearance by circulating antibodies that can be expressed at high levels. In particular, the staphylokinase variant is a variant of a wild-type staphylokinase selected from the group consisting of Sak42D, SakCOc* and SakSTAR. The amino acid variations introduced in said wild-type staphylokinase consist of E65D, K74Q, R77E, E8OS, D82S, V112T, K130Y, and E134R.
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